|
Name |
Accession |
Description |
Interval |
E-value |
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
19-476 |
0e+00 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 674.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 19 MRRIKHIHFVGIGGAGMCGIAEVLANQGYKISGSDIKASKTTQQLEENGIKVYIGHEAENIKNANVLVVSTAIDPENPEV 98
Cdd:COG0773 1 LDKIMHIHFIGIGGIGMSGLAEILLALGYKVSGSDLAESPMTERLEALGIPVFIGHDAENIDDADLVVVSSAIPRDNPEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 99 KAAIEQRIPIVRRAEMLGELMRYRHGIAVAGTHGKttttsllttmlAEENLDPTYVIGGLLNSTGVNAALGESRFIVAEA 178
Cdd:COG0773 81 VAARERGIPVLSRAEMLAELMRGKRSIAVAGTHGKttttsmlahilEEAGLDPTFLIGGILNNFGTNARLGDGDYFVAEA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 179 DESDASFLYLQPMAAIVTNIDADHMDTYeGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIREILPRVGRPVITYGFNED 258
Cdd:COG0773 161 DESDGSFLHYSPDIAVVTNIEADHLDIY-GDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPRCGRPVITYGFSED 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 259 NDIRAIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQVQGEfe 338
Cdd:COG0773 240 ADYRAENIRIDGGGSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGE-- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 339 lgEGNVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVDQLLLLEVYPAGEKPIVGA 418
Cdd:COG0773 318 --VGGVTVIDDYAHHPTEIAATLAAAREKYPDRRLVAVFQPHRYSRTRDFLDEFAEALSLADEVILLDIYAAREKPIPGV 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 445997617 419 DSRTLARSIRLRGQvEPILIDPVEgNLQNIMQNVLQPNDLLLTQGAGNVGAISVELAQ 476
Cdd:COG0773 396 SSEDLAEAIRKRGK-DVVYVPDLD-ELVEALAEIARPGDVVLTMGAGDIGGLGEKLLE 451
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
24-475 |
0e+00 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 595.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 24 HIHFVGIGGAGMCGIAEVLANQGYKISGSDIKASKTTQQLEENGIKVYIGHEAENIKNANVLVVSTAIDPENPEVKAAIE 103
Cdd:TIGR01082 1 KIHFVGIGGIGMSGIAEILLNRGYQVSGSDIAENATTKRLEALGIPIYIGHSAENLDDADVVVVSAAIKDDNPEIVEAKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 104 QRIPIVRRAEMLGELMRYRHGIAVAGTHGKTTTTSLLTTMLAEENLDPTYVIGGLLNSTGVNAALGESRFIVAEADESDA 183
Cdd:TIGR01082 81 RGIPVIRRAEMLAELMRFRHSIAVAGTHGKTTTTAMIAVILKEAGLDPTVVVGGLVKEAGTNARLGSGEYLVAEADESDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 184 SFLYLQPMAAIVTNIDADHMDTYEGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIREILPRVGRPVITYGFN-EDNDIR 262
Cdd:TIGR01082 161 SFLHLQPNVAIVTNIEPDHLDTYGSSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKATEQVITYGGSgEDADYR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 263 AIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQVQGEFelgeG 342
Cdd:TIGR01082 241 AENIQQSGAEGKFSVRGKGKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEILGEF----G 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 343 NVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVDQLLLLEVYPAGEKPIVGADSRT 422
Cdd:TIGR01082 317 GVLLIDDYAHHPTEIKATLKAARQGYPDKRIVVVFQPHRYSRTRDLFDDFAKVLSDADELILLDIYAAGEEPINGIDGKS 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 445997617 423 LARSIRLRGQVEPILIDPVEgNLQNIMQNVLQPNDLLLTQGAGNVGAISVELA 475
Cdd:TIGR01082 397 LARKITQLGKIEPYFVPDLA-ELVEFLAAVLQSGDLILTMGAGDIIKLARELL 448
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
19-470 |
1.06e-106 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 335.63 E-value: 1.06e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 19 MRRIKHIHFVGIGGAGMCGIAEVLANQGYKISGSDIKASKTTQQLEENGIKVYIGHEAENIKNANVLVVSTAIDPENPEV 98
Cdd:PRK14573 1 MMKSLFYHFIGIGGIGMSALAHILLDRGYSVSGSDLSEGKTVEKLKAKGARFFLGHQEEHVPEDAVVVYSSSISKDNVEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 99 KAAIEQRIPIVRRAEMLGELMRYRHGIAVAGTHGKTTTTSLLTTMLAEENLDPTYVIGGlLNSTGVNAALGESRFIVAEA 178
Cdd:PRK14573 81 LSAKSRGNRLVHRAELLAELMQEQISILVSGSHGKTTVSSLITAIFQEAKKDPSYAIGG-LNQEGLNGYSGSSEYFVAEA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 179 DESDASFLYLQPMAAIVTNIDADHMDTYEGSFDKLKDTFVQFLH-----NLPFYGlavvcGDDANIREILprVGrpvITY 253
Cdd:PRK14573 160 DESDGSLKHYTPEFSVITNIDNEHLSNFEGDRELLLASIQDFARkvqqiNKCFYN-----GDCPRLKGCL--QG---HSY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 254 GFNEDNDIRAIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQV 333
Cdd:PRK14573 230 GFSSSCDLHILSYYQEGWRSYFSAKFLGVVYQDIELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRLER 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 334 QGEFElgegNVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVDQLLLLEVYPAGEK 413
Cdd:PRK14573 310 KNSSE----TFLFLEDYAHHPSEISCTLRAVRDAVGLRRIIAICQPHRFSRLRECLDSFPSAFQDADEVILTDVYSAGEE 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 445997617 414 PIVGADSRTLARSIRLRGQVEPILIdPVeGNLQNIMQNVLQPNDLLLTQGAGNVGAI 470
Cdd:PRK14573 386 PEDSISYQKLAEAISQSSIVKCTYV-PF-HEIQRYLEQSIRVHDVCVSLGAGNIYTL 440
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
24-123 |
2.09e-26 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 101.93 E-value: 2.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 24 HIHFVGIGGAGMCGIAEVLANQGYKISGSDIKaskttQQLEENGIKVYIGHEAENiknanvlvvstAIDPENPEVKAAIE 103
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFI-----ESLIALGAAAVVGHDAAN-----------NISPDNPELEAAKV 64
|
90 100
....*....|....*....|
gi 445997617 104 QRIPIVRRAEMLGELMRYRH 123
Cdd:pfam01225 65 PGIPVIDRREALAELAAAFY 84
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
19-476 |
0e+00 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 674.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 19 MRRIKHIHFVGIGGAGMCGIAEVLANQGYKISGSDIKASKTTQQLEENGIKVYIGHEAENIKNANVLVVSTAIDPENPEV 98
Cdd:COG0773 1 LDKIMHIHFIGIGGIGMSGLAEILLALGYKVSGSDLAESPMTERLEALGIPVFIGHDAENIDDADLVVVSSAIPRDNPEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 99 KAAIEQRIPIVRRAEMLGELMRYRHGIAVAGTHGKttttsllttmlAEENLDPTYVIGGLLNSTGVNAALGESRFIVAEA 178
Cdd:COG0773 81 VAARERGIPVLSRAEMLAELMRGKRSIAVAGTHGKttttsmlahilEEAGLDPTFLIGGILNNFGTNARLGDGDYFVAEA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 179 DESDASFLYLQPMAAIVTNIDADHMDTYeGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIREILPRVGRPVITYGFNED 258
Cdd:COG0773 161 DESDGSFLHYSPDIAVVTNIEADHLDIY-GDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPRCGRPVITYGFSED 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 259 NDIRAIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQVQGEfe 338
Cdd:COG0773 240 ADYRAENIRIDGGGSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGE-- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 339 lgEGNVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVDQLLLLEVYPAGEKPIVGA 418
Cdd:COG0773 318 --VGGVTVIDDYAHHPTEIAATLAAAREKYPDRRLVAVFQPHRYSRTRDFLDEFAEALSLADEVILLDIYAAREKPIPGV 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 445997617 419 DSRTLARSIRLRGQvEPILIDPVEgNLQNIMQNVLQPNDLLLTQGAGNVGAISVELAQ 476
Cdd:COG0773 396 SSEDLAEAIRKRGK-DVVYVPDLD-ELVEALAEIARPGDVVLTMGAGDIGGLGEKLLE 451
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
24-475 |
0e+00 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 595.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 24 HIHFVGIGGAGMCGIAEVLANQGYKISGSDIKASKTTQQLEENGIKVYIGHEAENIKNANVLVVSTAIDPENPEVKAAIE 103
Cdd:TIGR01082 1 KIHFVGIGGIGMSGIAEILLNRGYQVSGSDIAENATTKRLEALGIPIYIGHSAENLDDADVVVVSAAIKDDNPEIVEAKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 104 QRIPIVRRAEMLGELMRYRHGIAVAGTHGKTTTTSLLTTMLAEENLDPTYVIGGLLNSTGVNAALGESRFIVAEADESDA 183
Cdd:TIGR01082 81 RGIPVIRRAEMLAELMRFRHSIAVAGTHGKTTTTAMIAVILKEAGLDPTVVVGGLVKEAGTNARLGSGEYLVAEADESDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 184 SFLYLQPMAAIVTNIDADHMDTYEGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIREILPRVGRPVITYGFN-EDNDIR 262
Cdd:TIGR01082 161 SFLHLQPNVAIVTNIEPDHLDTYGSSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKATEQVITYGGSgEDADYR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 263 AIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQVQGEFelgeG 342
Cdd:TIGR01082 241 AENIQQSGAEGKFSVRGKGKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEILGEF----G 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 343 NVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVDQLLLLEVYPAGEKPIVGADSRT 422
Cdd:TIGR01082 317 GVLLIDDYAHHPTEIKATLKAARQGYPDKRIVVVFQPHRYSRTRDLFDDFAKVLSDADELILLDIYAAGEEPINGIDGKS 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 445997617 423 LARSIRLRGQVEPILIDPVEgNLQNIMQNVLQPNDLLLTQGAGNVGAISVELA 475
Cdd:TIGR01082 397 LARKITQLGKIEPYFVPDLA-ELVEFLAAVLQSGDLILTMGAGDIIKLARELL 448
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
19-470 |
1.06e-106 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 335.63 E-value: 1.06e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 19 MRRIKHIHFVGIGGAGMCGIAEVLANQGYKISGSDIKASKTTQQLEENGIKVYIGHEAENIKNANVLVVSTAIDPENPEV 98
Cdd:PRK14573 1 MMKSLFYHFIGIGGIGMSALAHILLDRGYSVSGSDLSEGKTVEKLKAKGARFFLGHQEEHVPEDAVVVYSSSISKDNVEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 99 KAAIEQRIPIVRRAEMLGELMRYRHGIAVAGTHGKTTTTSLLTTMLAEENLDPTYVIGGlLNSTGVNAALGESRFIVAEA 178
Cdd:PRK14573 81 LSAKSRGNRLVHRAELLAELMQEQISILVSGSHGKTTVSSLITAIFQEAKKDPSYAIGG-LNQEGLNGYSGSSEYFVAEA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 179 DESDASFLYLQPMAAIVTNIDADHMDTYEGSFDKLKDTFVQFLH-----NLPFYGlavvcGDDANIREILprVGrpvITY 253
Cdd:PRK14573 160 DESDGSLKHYTPEFSVITNIDNEHLSNFEGDRELLLASIQDFARkvqqiNKCFYN-----GDCPRLKGCL--QG---HSY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 254 GFNEDNDIRAIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQV 333
Cdd:PRK14573 230 GFSSSCDLHILSYYQEGWRSYFSAKFLGVVYQDIELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRLER 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 334 QGEFElgegNVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVDQLLLLEVYPAGEK 413
Cdd:PRK14573 310 KNSSE----TFLFLEDYAHHPSEISCTLRAVRDAVGLRRIIAICQPHRFSRLRECLDSFPSAFQDADEVILTDVYSAGEE 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 445997617 414 PIVGADSRTLARSIRLRGQVEPILIdPVeGNLQNIMQNVLQPNDLLLTQGAGNVGAI 470
Cdd:PRK14573 386 PEDSISYQKLAEAISQSSIVKCTYV-PF-HEIQRYLEQSIRVHDVCVSLGAGNIYTL 440
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
23-349 |
2.72e-35 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 136.36 E-value: 2.72e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 23 KHIHFVGIGGAGMcGIAEVLANQGYKISGSDIKASK--TTQQLEENGIKVYIG-HEAENIKNANVLVVSTAIDPENPEVK 99
Cdd:COG0771 5 KKVLVLGLGKSGL-AAARLLAKLGAEVTVSDDRPAPelAAAELEAPGVEVVLGeHPEELLDGADLVVKSPGIPPDHPLLK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 100 AAIEQRIPIVrraemlGEL---MRYRHG--IAVAGTHGKttttsllttmlaeenldpTYV---IGGLLNSTGVNAALG-- 169
Cdd:COG0771 84 AARAAGIPVI------GEIelaYRLSPApiIAITGTNGK------------------TTTttlIGHILKAAGLRVAVGgn 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 170 ------EsrfIVAEADESDA------SF-L----YLQPMAAIVTNIDADHMDTYeGSFD-----KLKdtfvqFLHNLPFY 227
Cdd:COG0771 140 igtpllD---LLLEPEPPDVyvlelsSFqLettpSLRPDVAVILNITPDHLDRH-GSMEayaaaKAR-----IFANQTPD 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 228 GLAVVCGDDANIREILPRVGRPVITYGFNEDNDIRAidveqdGMRSHFTVLRKGREPLrLTINQ---PGLHNVLNALAAI 304
Cdd:COG0771 211 DYAVLNADDPLTRALAEEAKARVVPFSLKEPLEGGA------GLEDGKLVDRASGEEL-LPVDDlrlPGRHNLENALAAL 283
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 445997617 305 GVATDEGVSDEAISRALKGFSGVGRRFQVQGEFelgeGNVKLVDD 349
Cdd:COG0771 284 AAARALGVPPEAIREALRSFKGLPHRLEFVAEI----NGVRFIND 324
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
192-377 |
3.11e-30 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 122.49 E-value: 3.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 192 AAIVTNIDADHMDtYEGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIREILPRVGRPVITYGFNEDNDIRAIDVEQDGM 271
Cdd:COG0769 172 VAVFTNLTRDHLD-YHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRRLAAAAPARVITYGLKADADLRATDIELSAD 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 272 RSHFTVLRKGREpLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQVqgeFELGEGnVKLVDDYG 351
Cdd:COG0769 251 GTRFTLVTPGGE-VEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMER---VDGGQG-PTVIVDYA 325
|
170 180
....*....|....*....|....*.
gi 445997617 352 HHPKEVEATIKAARQsHPDRRLVMLF 377
Cdd:COG0769 326 HTPDALENVLEALRP-HTKGRLIVVF 350
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
189-349 |
1.26e-28 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 117.51 E-value: 1.26e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 189 QPMAAIVTNIDADHMdtyE--GSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIREILPRVGRPVITYGFNEDNDIRAIDV 266
Cdd:COG0770 175 RPDIAVITNIGPAHL---EgfGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKARVLTFGLSEDADVRAEDI 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 267 EQDGMRSHFTvLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQVqgefELGEGNVKL 346
Cdd:COG0770 252 ELDEDGTRFT-LHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEV----IEGAGGVTL 326
|
...
gi 445997617 347 VDD 349
Cdd:COG0770 327 IDD 329
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
24-123 |
2.09e-26 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 101.93 E-value: 2.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 24 HIHFVGIGGAGMCGIAEVLANQGYKISGSDIKaskttQQLEENGIKVYIGHEAENiknanvlvvstAIDPENPEVKAAIE 103
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFI-----ESLIALGAAAVVGHDAAN-----------NISPDNPELEAAKV 64
|
90 100
....*....|....*....|
gi 445997617 104 QRIPIVRRAEMLGELMRYRH 123
Cdd:pfam01225 65 PGIPVIDRREALAELAAAFY 84
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
24-349 |
7.53e-24 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 103.57 E-value: 7.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 24 HIHFVGIGGAGMcGIAEVLANQGYKISGSDIKAS---KTTQQLEEN--GIKVYIGHEAENIKNANVLVVSTAIDPENPEV 98
Cdd:TIGR01087 1 KILILGLGKTGR-AVARFLHKKGAEVTVTDLKPNeelEPSMGQLRLneGSVLHTGLHLEDLNNADLVVKSPGIPPDHPLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 99 KAAIEQRIPIVRRAEMLGELMRYRHgIAVAGTHGKTTTtsllttmlaeenldpTYVIGGLLNSTGVNAALGESRFIVA-- 176
Cdd:TIGR01087 80 QAAAKRGIPVVGDIELFLRLVPLPV-VAITGTNGKTTT---------------TSLLYHLLKAAGLKAFLGGNIGTPAle 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 177 EADESDASFLYLQ-------------PMAAIVTNIDADHMDTYeGSFD-----KLKdtfvqFLHNLPFYGLAVVCGDDAN 238
Cdd:TIGR01087 144 VLDQEGAELYVLElssfqletteslrPEIALILNISEDHLDWH-GSFEdyvaaKLK-----IFARQTEGDVAVLNADDPR 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 239 IREILPRVGRPVITYgFNEDNDIRAIDVEQDGmrshfTVLRKGREPLRLtinqPGLHNVLNALAAIGVATDEGVSDEAIS 318
Cdd:TIGR01087 218 FARLAQKSKAQVIWF-SVEKDAERGLCIRDGG-----LYLKPNDLEGSL----LGLHNAENILAAIALAKSLGLNLEAIL 287
|
330 340 350
....*....|....*....|....*....|.
gi 445997617 319 RALKGFSGVGRRFQVQGEFelgeGNVKLVDD 349
Cdd:TIGR01087 288 EALRSFKGLPHRLEYVGQK----NGVHFYND 314
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
160-307 |
2.45e-22 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 94.29 E-value: 2.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 160 NSTGVNAAL-----GESRFIVAEA-----DESDASFLyLQPMAAIVTNIDADHMDtYEGSFDKLKDTFVQFLHNLPFYGL 229
Cdd:pfam08245 41 NAIGLPLTLaemveAGAEYAVLEVsshglGEGRLSGL-LKPDIAVFTNISPDHLD-FHGTMENYAKAKAELFEGLPEDGI 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 230 AVVCGDD---ANIREILPRVGRPVITYGFNEDNDIRAIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNALAAIGV 306
Cdd:pfam08245 119 AVINADDpygAFLIAKLKKAGVRVITYGIEGEADLRAANIELSSDGTSFDLFTVPGGELEIEIPLLGRHNVYNALAAIAA 198
|
.
gi 445997617 307 A 307
Cdd:pfam08245 199 A 199
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
32-363 |
1.47e-21 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 96.96 E-value: 1.47e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 32 GAGMCGIA--EVLANQGYKISGSDIKAS----KTTQQLEENGIKVYIG-HEAENIKNANVLVVSTAIDPENPEVKAAIEQ 104
Cdd:PRK14106 12 GAGVSGLAlaKFLKKLGAKVILTDEKEEdqlkEALEELGELGIELVLGeYPEEFLEGVDLVVVSPGVPLDSPPVVQAHKK 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 105 RIPIvrraemLGEL-MRYR----HGIAVAGTHGKTTTTSLLTTMlAEENLDPTYV---IGGLLNSTGVNAalGESRFIVA 176
Cdd:PRK14106 92 GIEV------IGEVeLAYRfskaPIVAITGTNGKTTTTTLLGEI-FKNAGRKTLVagnIGYPLIDAVEEY--GEDDIIVA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 177 EAdesdASF-----LYLQPMAAIVTNIDADHMDTYeGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIREILPRVGRPVI 251
Cdd:PRK14106 163 EV----SSFqletiKEFKPKVGCILNITPDHLDRH-KTMENYIKAKARIFENQRPSDYTVLNYDDPRTRSLAKKAKARVI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 252 TygFNEDNDI-RAIDVEQDgmrshFTVLRKG--REPL--RLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSG 326
Cdd:PRK14106 238 F--FSRKSLLeEGVFVKNG-----KIVISLGgkEEEVidIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKG 310
|
330 340 350
....*....|....*....|....*....|....*...
gi 445997617 327 VGRRFQVQGEFElgegNVKLVDDY-GHHPkevEATIKA 363
Cdd:PRK14106 311 VEHRIEFVAEIN----GVKFINDSkGTNP---DAAIKA 341
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
192-377 |
2.24e-15 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 78.25 E-value: 2.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 192 AAIVTNIDADHMDtYEGSFDKLKDTFVQFLHNLpfYGLAVVCGDDANIREILPRVGRPVITYgfnEDNDIRAIDVEQDGM 271
Cdd:PRK00139 187 VAVFTNLSRDHLD-YHGTMEDYLAAKARLFSEL--GLAAVINADDEVGRRLLALPDAYAVSM---AGADLRATDVEYTDS 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 272 RSHFTVLRKGREPLrltinqPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQVQGefelGEGNVKLVDDYG 351
Cdd:PRK00139 261 GQTFTLVTEVESPL------IGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMERVD----AGQGPLVIVDYA 330
|
170 180
....*....|....*....|....*.
gi 445997617 352 HHPKEVEATIKAARQsHPDRRLVMLF 377
Cdd:PRK00139 331 HTPDALEKVLEALRP-HAKGRLICVF 355
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
192-377 |
2.56e-15 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 78.98 E-value: 2.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 192 AAIVTNIDADHMDtYEGSFDKLKDTFVQFLHNLPFYGLAVVCGDD---ANIREILPRVGRpVITYGFNEDNDIRAIDVEQ 268
Cdd:PRK11929 204 VAGFTNLTRDHLD-YHGTMQDYEEAKAALFSKLPGLGAAVINADDpaaARLLAALPRGLK-VGYSPQNAGADVQARDLRA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 269 DGMRSHFTvLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQVQGEFELGEGNVKLVd 348
Cdd:PRK11929 282 TAHGQVFT-LATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMERVGPTAGAQGPLVVV- 359
|
170 180 190
....*....|....*....|....*....|.
gi 445997617 349 DYGHHPKEVEATIKAARQSHPDR--RLVMLF 377
Cdd:PRK11929 360 DYAHTPDALAKALTALRPVAQARngRLVCVF 390
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
188-363 |
5.72e-15 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 76.54 E-value: 5.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 188 LQPMAAIVTNIDADHMDTYeGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIREILPRV-GRPVITYGFNeDNDIRAIDV 266
Cdd:TIGR01143 148 AKPDIAVITNIGPAHLEGF-GSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLpNRNILSFGFE-GGDFVAKDI 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 267 EQDGMRS-HFTVLRKGREpLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQVQgefelGEGNVK 345
Cdd:TIGR01143 226 SYSALGStSFTLVAPGGE-FEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVQ-----TKNGLT 299
|
170
....*....|....*....
gi 445997617 346 LVDD-YGHHPKEVEATIKA 363
Cdd:TIGR01143 300 LIDDtYNANPDSMRAALDA 318
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
327-418 |
2.01e-13 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 65.83 E-value: 2.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 327 VGRRFQVQGEFelgeGNVKLVDDYGHHPKEVEATIKAARQsHPDRRLVMLFQPHRySRTRDCFDDFIEVLSQV-DQLLLL 405
Cdd:pfam02875 1 VPGRLEVVGEN----NGVLVIDDYAHNPDAMEAALRALRN-LFPGRLILVFGGMG-DRDAEFHALLGRLAAALaDVVILT 74
|
90
....*....|...
gi 445997617 406 EVYPAGEKPIVGA 418
Cdd:pfam02875 75 GDYPRAEDPGAII 87
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
189-363 |
6.17e-12 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 68.19 E-value: 6.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 189 QPMAAIVTNIDADHMDTYeGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIREILPRVG-RPVITYGFNEDNDIRAIDVE 267
Cdd:PRK11929 681 APTVALVTNAQREHQEFM-HSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGaRRVLRFGLQPGADVYAEKIA 759
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 268 QDGMRSHFTVLR----KGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQVQgefELGEGN 343
Cdd:PRK11929 760 KDISVGEAGGTRcqvvTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRR---RLSCGT 836
|
170 180
....*....|....*....|
gi 445997617 344 VKLVDDYGHHPKEVEATIKA 363
Cdd:PRK11929 837 RIIDDTYNANPDSMRAAIDV 856
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
192-377 |
3.12e-10 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 61.95 E-value: 3.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 192 AAIVTNIDADHMDtYEGSFDKLKDTFVQFLHNLPFYGLAVVCGDD---ANIREILPR--VGRPVITYGFNEDNDIRAIDV 266
Cdd:TIGR01085 180 AAVFTNLSRDHLD-FHGTMENYFAAKASLFTELGLKRFAVINLDDeygAQFVKRLPKdiTVSAITQPADGRAQDIKITDS 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 267 EQDGMRSHFTVLRKGrEPLRLTINQPGLHNVLNALAAI-GVATDEGVSDEAISRALKGFSGVGRRFQVqgeFELGEGNVK 345
Cdd:TIGR01085 259 GYSFEGQQFTFETPA-GEGHLHTPLIGRFNVYNLLAALaTLLHLGGIDLEDIVAALEKFRGVPGRMEL---VDGGQKFLV 334
|
170 180 190
....*....|....*....|....*....|..
gi 445997617 346 LVdDYGHHPKEVEATIKAARQsHPDRRLVMLF 377
Cdd:TIGR01085 335 IV-DYAHTPDALEKALRTLRK-HKDGRLIVVF 364
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
193-324 |
3.37e-07 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 52.85 E-value: 3.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 193 AIVTNIDADH-----MDTYEGSFdKLKDTFVQFLHNlpfYGLAVVCGDDANIREILPRVGRPVITYGFNEDNDI------ 261
Cdd:PRK14016 569 GVVTNIGEDHlglggINTLEDLA-KVKRVVVEAVKP---DGYAVLNADDPMVAAMAERCKGKVIFFSMDPDNPViaehra 644
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445997617 262 ---RAIDVEQDGMrshftVLRKGR--------EPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGF 324
Cdd:PRK14016 645 qggRAVYVEGDYI-----VLAEGGweiriislADIPLTLGGKAGFNIENALAAIAAAWALGIDIELIRAGLRTF 713
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
190-350 |
1.53e-06 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 50.42 E-value: 1.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 190 PMAAIVTNIDADHMDTYeGSFDKLKDTFVQFLHNLPFYGLAVVCGDD---ANIREILPrvGRPVITYGFN--EDNDIRAI 264
Cdd:PRK10773 176 PEAALVNNLAAAHLEGF-GSLAGVAKAKGEIFSGLPENGIAIMNADSndwLNWQSVIG--SKTVWRFSPNaaNSVDFTAT 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445997617 265 DVEQDGMRSHFTvLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGV-GRRFQVQgefeLGEGN 343
Cdd:PRK10773 253 NIHVTSHGTEFT-LHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVpGRLFPIQ----LAEGQ 327
|
....*..
gi 445997617 344 VKLVDDY 350
Cdd:PRK10773 328 LLLDDSY 334
|
|
| |
