|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
13-419 |
0e+00 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 637.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 13 IFKGSVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVM 92
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 93 AGGSLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVL 172
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 173 QQLLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFSNIKSQKRESAGTVRALMKHPKAVLTVVGLTLGGTVAFY 252
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRELRRHPRELLLVVGLTAGGTLAFY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 253 TYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAF 332
Cdd:cd17367 241 TWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 333 LLMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAISFITY 412
Cdd:cd17367 321 ALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVFFWYVAGLIAISLVVY 400
|
....*..
gi 446002013 413 WRMDESS 419
Cdd:cd17367 401 LRMPETR 407
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
13-410 |
2.27e-165 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 471.99 E-value: 2.27e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 13 IFKGSVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVM 92
Cdd:PRK10406 24 IVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCMM 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 93 AGGSLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVL 172
Cdd:PRK10406 104 CFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 173 QQLLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESeqfSNIKSQKRESAGTVRALMKHPKAVLTVVGLTLGGTVAFY 252
Cdd:PRK10406 184 QQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET---SQQETRALKEAGSLKGLWRNRRAFIMVLGFTAAGSLCFY 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 253 TYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAF 332
Cdd:PRK10406 261 TFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAALFTVPILSALQNVSSPYAAF 340
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446002013 333 LLMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAISFI 410
Cdd:PRK10406 341 GLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFL 418
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
19-407 |
1.25e-140 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 407.81 E-value: 1.25e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 19 GNLIEWYDWYVYSAFAVY-FSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSL 97
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLvFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 98 IIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLLS 177
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 178 EPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFSNIKSQKRESAGTVRALM-KHPKAVLTVVGLTLGGTVAFYTYTT 256
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGPIAETLtKHRKPFLLGLGLVIATTTTFYLITT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 257 YLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMM 336
Cdd:TIGR00883 241 YLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFFFLVL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446002013 337 VGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAI 407
Cdd:TIGR00883 321 GMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALAL 391
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
16-413 |
2.09e-107 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 323.32 E-value: 2.09e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 16 GSVGNLIEWYDWYVY-SAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAG 94
Cdd:cd17369 7 SLVGTAIEWYDFFIYgTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 95 GSLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQ 174
Cdd:cd17369 87 ATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 175 LLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFSNIK-SQKRESAGTVRALMKHPKAVLTVVGLTLGGTVAFYT 253
Cdd:cd17369 167 LLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKeAGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 254 YTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFL 333
Cdd:cd17369 247 FTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 334 LMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLkSIGMESLFY--FYVAGCIAISFIT 411
Cdd:cd17369 327 AVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATAL-VAATGSWWPvaLYLAALAVISLVA 405
|
..
gi 446002013 412 YW 413
Cdd:cd17369 406 AL 407
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
13-417 |
1.62e-91 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 282.73 E-value: 1.62e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 13 IFKGSVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVM 92
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 93 AGGSLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQyvtlVAGQMVALGVQIVL 172
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQ----SASQQVAIVAGALV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 173 QQLLS----EPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFSNIKsQKRESAGTVRALMKHPKAVLTVVGLTLGGT 248
Cdd:cd17368 157 GYLLSltltAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERK-ARPTRRELFALLANNRRIILLGMLLVAGST 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 249 VAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMekTTEP 328
Cdd:cd17368 236 VTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWL--TAAP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 329 IVAFLLMMVGLI--IVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWL-KSIGMESLFYFYVAGCI 405
Cdd:cd17368 314 SFGRLLLVLLVLsfFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLiELTGSPLAPAWYLMGAA 393
|
410
....*....|..
gi 446002013 406 AISFITYWRMDE 417
Cdd:cd17368 394 LLGLLATLMLRE 405
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
10-388 |
6.55e-86 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 269.12 E-value: 6.55e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 10 AGNIFKGSVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSI 89
Cdd:PRK15075 14 ARAILRVTSGNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 90 TVMAGGSLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQ 169
Cdd:PRK15075 94 SIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 170 IVLQQLLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFSNIKsqKRESAGTV-RALMKHPKAVLTVVGLTLGGT 248
Cdd:PRK15075 174 YLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARK--HRPSMREIfRSLAANWRIVLAGMLMVAMTT 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 249 VAFYTYTTYLQKFMVNTVGLPKE---VVSWinFVALLIFVVLqPIAGLLSDKIGRRPLLMAFGILgTLLTA-PIFFFMek 324
Cdd:PRK15075 252 VSFYLITVYTPTFGKTVLHLSAAdslLVTL--CVGVSNFIWL-PIGGALSDRIGRRPVLIAFTVL-AILTAyPALSWL-- 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446002013 325 TTEPIVAFLLmMVGLIIVTGYTSIN-AIVKA--ELFPTEIRALGVGLPYALTVAIFGGTAEFIALWL 388
Cdd:PRK15075 326 VAAPSFARML-AVELWLSFLYGSYNgAMVVAltEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWL 391
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
17-419 |
1.31e-79 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 251.12 E-value: 1.31e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 17 SVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGS 96
Cdd:cd17366 5 ALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAAST 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 97 LIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLL 176
Cdd:cd17366 85 FCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 177 SEPDMKAWGWRIPFIIGAMGAVAVLWLRRtmdeseqfsniksqkresagtvralmkhpkAVLTVVGLTLGGTVAFYTYTT 256
Cdd:cd17366 165 TEAQMLDWGWRIPFLIAAPLGLVGLYLRR------------------------------PLLICIGLVLVFNVTNYMLLS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 257 YLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLmAFGILGTLLTA-PIFFFMEKTTEPIVAFLLM 335
Cdd:cd17366 215 YMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVY-AAGLAGLLVLAvPAFLLMNSGSIAAIFIGLL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 336 MVGLIIVTgYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSI-GMESLFYFYVAGCIAISFITYWR 414
Cdd:cd17366 294 VLGLLLSC-YTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSAtGNPLMPAYYLMVAAVVGLVAVLF 372
|
....*
gi 446002013 415 MDESS 419
Cdd:cd17366 373 LTETA 377
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
13-411 |
1.72e-68 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 221.32 E-value: 1.72e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 13 IFKGSVGNLIEWYDWYVYSAFAVYFSAEFfpkgDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVM 92
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 93 AGGSLIIACTPSyesigimaPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVL 172
Cdd:cd17316 77 GLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 173 QQLLSEPdmkaWGWRIPFIIGAMGAVAVLWLRRTMdeseqfsniksqkresagtvralmkhpkavLTVVGLTLGGTVAFY 252
Cdd:cd17316 149 IPLLSGD----WGWRILFLIGALPALLALLLRRRT------------------------------LLLILLWFFISFGYY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 253 TYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMekTTEPIVAF 332
Cdd:cd17316 195 GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLL--SGSPTLLL 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446002013 333 LLMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAISFIT 411
Cdd:cd17316 273 LLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
18-419 |
5.68e-61 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 204.58 E-value: 5.68e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 18 VGNLIEWYDWYVYS-AFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGS 96
Cdd:PRK09952 29 AGAVVDWYDFLLYGiTAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLTVWMMGIAT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 97 LIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLL 176
Cdd:PRK09952 109 ALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMT 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 177 SEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFSNIKSQK---RESAGTVRALMKHPKAVLTVVGLTLGGTVAFYT 253
Cdd:PRK09952 189 TDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQaaaKKRIPVIEALLRHPGAFLKIIALRLCELLTMYI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 254 YTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFL 333
Cdd:PRK09952 269 VTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFWIVFF 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 334 LMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFY---FYVAGCIaISFI 410
Cdd:PRK09952 349 SIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTYFGGSWHSvaiYLLAGCL-ISAM 427
|
....*....
gi 446002013 411 TYWRMDESS 419
Cdd:PRK09952 428 TALLMKDNQ 436
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
13-419 |
3.57e-59 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 201.09 E-value: 3.57e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 13 IFKGSVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVM 92
Cdd:PRK10642 18 ITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 93 AGGSLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVL 172
Cdd:PRK10642 98 SISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLI 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 173 QQLLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFS-NIKSQKRESAGTVRA---------LMKHPKAVLTVVG 242
Cdd:PRK10642 178 STIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQqHVDKLEQGDREGLQDgpkvsfkeiATKHWRSLLTCIG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 243 LTLGGTVAFYTYTTYLQKFMVNTVGLPKE--VVSWINFVALLIFVvlQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFF 320
Cdd:PRK10642 258 LVIATNVTYYMLLTYMPSYLSHNLHYSEDhgVLIIIAIMIGMLFV--QPVMGLLSDRFGRRPFVILGSVALFVLAIPAFI 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 321 FMEKTTEPIVAFLLMMVGLIIvTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFY 400
Cdd:PRK10642 336 LINSNVIGLIFAGLLMLAVIL-NCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESTQNLMMPAYY 414
|
410
....*....|....*....
gi 446002013 401 VAGCIAISFITYWRMDESS 419
Cdd:PRK10642 415 LMVVAVIGLITGVTMKETA 433
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
12-415 |
4.55e-37 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 139.63 E-value: 4.55e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 12 NIFKGSVGNLIEWYDWYVYSAFAVYFSAEFfpkGDPTSQLlntAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITV 91
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEF---GLSAAQL---GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 92 MAGGSLIIACTPSYEsigimapiILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVAlgvqiv 171
Cdd:COG2223 80 LGIGLLLLALAVSYW--------LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVA------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 172 lqQLLSEPDMKAWGWRIPFII-GAMGAVAVLWLRRTMDESEQFsnIKSQKRESAGTVRALMKHPKAVLTVVGLTLGGTvA 250
Cdd:COG2223 146 --AFLAPLLIAAFGWRNAFLIlGILLLVVAVLAWLFLRDPPAG--AAAAAKASLRDQLEALRDPRFWLLSLLYFGTFG-S 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 251 FYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIV 330
Cdd:COG2223 221 FIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLV 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 331 AFLLMMVGLIIvtGYTSINAIVkAELFPTEIRALGVGLPYALtVAIFGGTAEFIALWLKSI-GMESLFYFYVAGCIAISF 409
Cdd:COG2223 301 LFLLLGLALGG--GNGAVFALV-PDIFPTKNAGAVYGLVGAA-GGLGGFLGPLLFGALLDAtGSYTAAFLVFAVLALVAL 376
|
....*.
gi 446002013 410 ITYWRM 415
Cdd:COG2223 377 VLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-368 |
1.34e-32 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 126.24 E-value: 1.34e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 17 SVGNLIEWYDWYVYSAFAVYFSAEFfpkGDPTSQLlntAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGS 96
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADL---GASPAQA---GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 97 LIIACTPSYEsigimapiILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQll 176
Cdd:COG2814 90 LLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 177 sepdmkAWGWRIPFIIGA-MGAVAVLWLRRTMDESEqfsniKSQKRESAGTVRALMKHPkAVLTVVGLTLGGTVAFYTYT 255
Cdd:COG2814 160 ------LFGWRWVFLVNAvLALLALLLLLRLLPESR-----PAARARLRGSLRELLRRP-RLLLLLLLAFLLGFGFFALF 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 256 TYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAfGILGTLLTAPIFFFMekTTEPIVAFLLM 335
Cdd:COG2814 228 TYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI-GLLLLALGLLLLALA--GSLWLLLLALF 304
|
330 340 350
....*....|....*....|....*....|...
gi 446002013 336 MVGLIIVTGYTSINAIVkAELFPTEIRALGVGL 368
Cdd:COG2814 305 LLGFGFGLLFPLLQALV-AELAPPEARGRASGL 336
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
17-418 |
1.44e-28 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 116.99 E-value: 1.44e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 17 SVGNLIEWYDWYVYSAFA--VYFSAEFF------PKGDPTSQLLNTAAIFAVGflmRPIGSLLMGRYADRHGRRAALTLS 88
Cdd:pfam00083 6 ALGGFLFGYDTGVIGAFLtlIDFFKNFGlsksvsSLAALSVLSGLIVSIFSVG---CFIGSLFAGKLGDRFGRKKSLLIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 89 ITVMAGGSLIIACTPSYESIGImapiiLVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGV 168
Cdd:pfam00083 83 NVLFVIGAVLQGAAKGKWSVYQ-----LIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 169 QivlqqLLSEPDMKAWGWRIPFIIGAMGAVAVL---------------------------WLRRTMDESEQFSNIK---- 217
Cdd:pfam00083 158 G-----LGLNKTSNSDGWRIPLGLQLVPALLLIigllflpesprwlvekgrleearevlaKLRGVPDVDRELDEIKdsle 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 218 ---SQKRESAGTVRALMKHPKAVLTVVGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVvsWINFVALLIFVVLQPIAGLL 294
Cdd:pfam00083 233 agqEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSF--LVTIIVGVVNFVFTFIAIFL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 295 SDKIGRRPLLM---AFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIV---TGYTSINAIVKAELFPTEIRALGVGL 368
Cdd:pfam00083 311 VDRFGRRPLLLlgaAGMAICFVILGIVALLGVSKSDWAGIVAIVFIALFIAffaMGWGPVPWVIVSELFPLSVRSKAMAL 390
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 446002013 369 PYALTVaIFGGTAEFIALWL-KSIGMESLFYFYVAGCIAISFITYWRMDES 418
Cdd:pfam00083 391 ATAANW-LANFLIGFLFPIItDAIGLGYTFFIFAGLLVLFIIFVFFFVPET 440
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-415 |
9.97e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 110.34 E-value: 9.97e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 17 SVGNLIEWYDWYVYSAFAVYFSAEFfpkGDPTSQLlntAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGS 96
Cdd:COG2271 16 FLAYFLNYLDRSNLSVAAPPLQADL---GLSAAQL---GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 97 LIIACTPSYESigimapiiLVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLqqll 176
Cdd:COG2271 90 LLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL---- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 177 sepdMKAWGWRIPFIIGAMGAVAVLWLRrtmdeseqfsniksqkresagtvralmkhpkaVLTVVGLTLGGTVAFYTYTT 256
Cdd:COG2271 158 ----LAAFGWRAAFLILGLPGLLLALLR--------------------------------FWLLALAYFLVYFALYGFLT 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 257 YLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAfgILGTLLTAPIFFFMEKTTEPIVAFLLMM 336
Cdd:COG2271 202 WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL--AIGLLLAALALLLLALLPSPALAIALLF 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446002013 337 VGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFyVAGCIAISFITYWRM 415
Cdd:COG2271 280 LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL-LAALALLAALLALLL 357
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
67-410 |
1.14e-26 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 110.47 E-value: 1.14e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYEsigimapiILVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17371 49 IGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYW--------QLLILRALAGLGFGGEWAAGAALMAEYVPARH 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFyssfQYVTLVAGQMVALGVQIVLQQLLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFSNIKSQKRESA-G 225
Cdd:cd17371 121 RGK----ALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFAdR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 226 TVRALMKHPKAVLTVVGLTLGGTVA---FYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRP 302
Cdd:cd17371 197 PSLRELFSPPLLRTTLLASLLATGAlggYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 303 LLmAFGILGTLLTAPIFFFMEKTTEPIVafLLMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYAL---TVAIFGG 379
Cdd:cd17371 277 NF-ALFALGSAISILLYFFLPLSPTLIL--ILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVgriIGALFPF 353
|
330 340 350
....*....|....*....|....*....|....
gi 446002013 380 TAEFIAL---WLKSIGMESLFYfYVAGCIAISFI 410
Cdd:cd17371 354 LVGFLATsgsLGTAIAVFAAVY-YIAGLVLALLL 386
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
17-322 |
1.40e-25 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 105.66 E-value: 1.40e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 17 SVGNLIEWYDWYVYSAFAVYFSAEFfpkGDPTSQLlntAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGS 96
Cdd:COG0477 20 ALGTFLEGLDFTIVNVALPSIAADL---GASSAQL---GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 97 LIIACTPSyesigimaPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQll 176
Cdd:COG0477 94 LLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA-- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 177 sepdmkAWGWRIPFIIGAMGAVAVLWLRRTMDESeqfsniksqkRESAGTVRALMKHPKAVLTVVGLTLGGTVAFYTYTT 256
Cdd:COG0477 164 ------ALGWRWIFLINAPLGLLALVLRLRLPES----------RGLLLALLALALAALLLAALALALLALLLLLLLLLL 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446002013 257 YLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFM 322
Cdd:COG0477 228 ALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
67-415 |
1.68e-22 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 98.41 E-value: 1.68e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYesigimapIILVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNF--------TIFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFYSSFQYVTLVAGQMVALGVQIVLQQLLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFsniksqkresagt 226
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 227 vrALMKHPKAVLTVVGLTL-----GGTVAFYTYTTYLQKfmvntVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRR 301
Cdd:cd17359 190 --LVSKGKPILIIGIGLAIfqqfvGINVIFYYGPEIFQN-----AGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 302 PLLM--AFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVTGYTSINAIV---KAELFPTEIRALGVGLP-YALTVA 375
Cdd:cd17359 263 PLLLigSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTwvlLSEIFPNRIRGLAMGIAvFFLWIA 342
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446002013 376 IFGGTAEFIALwLKSIGMESLFYFYVAGCIaISFITYWRM 415
Cdd:cd17359 343 NFLVSLTFPIL-LAAFGLAFTFLIFAVICV-LAFLFVWKF 380
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
57-414 |
1.85e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 98.42 E-value: 1.85e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 57 IFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYEsigimapiILVLARLLQGLSLGGEYGTSAT 136
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW--------QLLLARFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 137 YLSEMASSGRRG----FYSSFQYVTLVAGqmvalgvqIVLQQLLSEpdmkAWGWRIPFII-GAMGAVAVLWLRRTMDESE 211
Cdd:cd17325 108 LIADIAPPEERGramgIFSSAIGLGFLIG--------PLLGGLLAD----ALGYRAPFLVcAALALLALVLALLLLPEPR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 212 QFSNIKSQKRESAGTVRALMKHPKAVLTVVGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIA 291
Cdd:cd17325 176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 292 GLLSDKIGRRPLLMAFGILGTLLTAPIFFFmekTTEPIVAFLLMMVGLIIVTGYTSINAIVkAELFPTEIRALGVGLpYA 371
Cdd:cd17325 256 GKLSDRIGRKPLILIGLLLSAVALLLLPLA---TSFWLLLLLLALLGLGLGLVFPATLALL-ADIVPPEGRGTAMGL-FN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 446002013 372 LTVAIFGGTAEFIALWL-KSIGMESLFYFYVAGCIAISFITYWR 414
Cdd:cd17325 331 TAFSLGMVLGPLLGGFLyDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-368 |
4.23e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 90.94 E-value: 4.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 17 SVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGflmrpIGSLLMGRYADRHGRRAALTLSITVMAGGS 96
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYA-----LAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 97 LIIACTPSYEsigimapiILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLqqll 176
Cdd:pfam07690 77 LLLLFASSLW--------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL---- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 177 sepdMKAWGWRIPFIIGA--MGAVAVLWLRRTMDESEQFSNIKSQKRESAGTVRALMKHPKAVLTVVGLtLGGTVAFYTY 254
Cdd:pfam07690 145 ----ASLFGWRAAFLILAilSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 255 TTYLQKFMvNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLL 334
Cdd:pfam07690 220 LTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL 298
|
330 340 350
....*....|....*....|....*....|....
gi 446002013 335 MMVGLIIVTGYTSINAIVkAELFPTEIRALGVGL 368
Cdd:pfam07690 299 LLLGFGFGLVFPALNALV-SDLAPKEERGTASGL 331
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
67-337 |
9.35e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 90.30 E-value: 9.35e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESigimapiiLVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--------LLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFYSSfqyvTLVAGQMVALGVQIVLQQLLSEpdmkAWGWRIPF-IIGAMGAVAVLWLRRTMDESEQFsniKSQKRESAG 225
Cdd:cd17324 121 RGRAIG----LVFSGLTLGLVLGRPLGGLLGQ----LLGWRAAFlAIAVLALLAALLLWRLLPSLPPK---KPGSLGLLS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 226 TVRALMKHPKAVLTVVGLTLGGTvAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLM 305
Cdd:cd17324 190 SLLLLLRNPRLRLAYLITFLLFG-GFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268
|
250 260 270
....*....|....*....|....*....|..
gi 446002013 306 AFGILGTLLTAPIFFfmekTTEPIVAFLLMMV 337
Cdd:cd17324 269 ALLLLAAALLLLTLL----GPSPLLLLVGLVL 296
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
16-417 |
3.42e-19 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 88.40 E-value: 3.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 16 GSVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLnTAAIFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGG 95
Cdd:cd17315 2 AALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGL-VVSSLLLGAA---IGSLFGGPLADRFGRRKSLLIAAVLYVIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 96 SLIIACTPSYEsigimapiILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQl 175
Cdd:cd17315 78 ALLSALAPNVW--------VLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSL- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 176 lsepdMKAWGWRIPFIIGAMGAVAVLWLRRTMDESeqfsniksqkresagtvralmkhpKAVLTVVGLTL-----GGTVA 250
Cdd:cd17315 149 -----SPPGWWRLMFALAAVPALLQLLLMFFLPES------------------------RALLVGVGLQLlqqltGINAV 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 251 FYTYTTYLQKFMVNTVGLpkevvsWINFVALLIFVVLQPIAGLLSDKIGRRPLLMaFGILGT-----LLTAPIFFFMEKT 325
Cdd:cd17315 200 MYYAPTIFKSAGGGTASI------LASIIVGVVNLLATLVAIRLVDKVGRRPLLL-IGFAGMaasllLLAIAFLLPALAK 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 326 TEPIVAFLLMMVGLII-VTGYTSINAIVKAELFPTEIRALGVglpyALTVAIFGGTAEFIAL----WLKSIGMESLFYFY 400
Cdd:cd17315 273 AAGWLALLGILLYIAAfAMGAGPVPWLLLSEIFPLRIRGKGM----AIATLVNWIFNFIVGLtfliMVSTIGLAGVFIFF 348
|
410
....*....|....*..
gi 446002013 401 VAGCIAISFITYWRMDE 417
Cdd:cd17315 349 AAVCLLALVFVFFFVPE 365
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-413 |
3.96e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 88.64 E-value: 3.96e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 17 SVGNLIEWYDWYVYSAFAVYFSAEFfpkGDPTSQLLNTAAIFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGGS 96
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSF---GLSASQLGLLFALFSLGYA---LLQPLAGLLADRFGRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 97 LIIACTPSYesigimapIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLL 176
Cdd:cd06174 76 LLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 177 SepdmkaWGWRIPFIIGAMGAVAVLWLRRTMDESEQFSNIKSQKRESAGTVRALMK---HPKAVLTVVGLTLGGTVAFYT 253
Cdd:cd06174 148 G------FGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKrvlKNPGLWLLLLAIFLVNLAYYS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 254 YTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTapIFFFMEKTTEPIVAFL 333
Cdd:cd06174 222 FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALG--LALLLLAPSLLLLLLL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 334 LMMVGLIIVTGYTSINAIVkAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAISFITYW 413
Cdd:cd06174 300 LLLLGFGLGGLLPLSFALI-AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
54-417 |
4.50e-18 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 86.16 E-value: 4.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 54 TAAIFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACtpsyeSIGIMAPIILVLARLLQGLSLGGEYGT 133
Cdd:cd17357 54 IVSIFFIGGA---IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFL-----SKSAKSPELLIFGRFLVGIACGLSTGF 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 134 SATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGvqIVLQQLLSEPDMKAWGWRIPFIIGAMGAVAVLW----------- 202
Cdd:cd17357 126 VPMYLQEISPSELRGALGSLTQIGVTLGILLGQV--FGLPSVLGTETLWPYLLFFPGIPALLQLAALPFfpespkfllis 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 203 -------------LRRTMDE--SEQFSNIKSQKRE---SAGTVRALMKH-----PKAVLTVVGLT--LGGTVAFYTYTTy 257
Cdd:cd17357 204 kgdeeeaekslkfLRGIEDDvdQELEEIKKESEQMgdqKQVSLMQLLRDpslrlPLLLVLVVSASqqFSGINAIFFYST- 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 258 lqkFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMaFGILGTLLTAPIFFFMEKTTEPIVAFLLMMV 337
Cdd:cd17357 283 ---FIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLL-ISLSVCAVALLLMSVFLFLSEQNSWMSYGCI 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 338 GLIIVTGYT------SINAIVKAELFPTEIRALGVGLPYAL-TVAIFggTAEFIALWLKSIGMESLFYFYVAGCIAISFI 410
Cdd:cd17357 359 VAIFLFIFFfaiglgPIPWFIGAELFPQAPRSAAQSLGSSVnWTSNF--IVGMAFPPLQSIGGGFVFIIFAIPCALFLLY 436
|
....*..
gi 446002013 411 TYWRMDE 417
Cdd:cd17357 437 LYRYLPE 443
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
51-241 |
6.62e-18 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 85.90 E-value: 6.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 51 LLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESigimapiiLVLARLLQGLSLGGE 130
Cdd:PRK03893 54 TVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWT--------LFIARLVIGMGMAGE 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 131 YGTSATYLSEMASSGRRGFYSSFqyvtLVAGQMVALGVQIVLQQLLSEPdmkaWGWRIPFIIGAMGAVAVLWLRRTMDES 210
Cdd:PRK03893 126 YGSSATYVIESWPKHLRNKASGF----LISGFSIGAVVAAQVYSLVVPV----WGWRALFFIGILPIIFALWLRKNLPEA 197
|
170 180 190
....*....|....*....|....*....|....*
gi 446002013 211 EQFSNIKSQKRESAGTVRALM----KHPKAVLTVV 241
Cdd:PRK03893 198 EDWKEKHAGKAPVRTMVDILYrgehRIINILLTLA 232
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
57-378 |
5.54e-17 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 82.40 E-value: 5.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 57 IFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESigimapiiLVLARLLQGLSLGGEYGTSAT 136
Cdd:TIGR00895 57 LFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 137 YLSEMASSGRRGFYSSFQYVTLVAGQMVAlgvqivlqQLLSEPDMKAWGWRIPFIIGAMGAVAVLW-LRRTMDESEQF-- 213
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVG--------GFLAGWLIPVFGWRSLFYVGGIAPLLLLLlLMRFLPESIDFlv 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 214 -----------SNIKSQKRESAGT--------------VRALMKHPKAVLTVVGLTLG---GTVAFYTYTTYLQKFMVNT 265
Cdd:TIGR00895 201 skrpetvrrivNAIAPQMQAEAQSalpeqkstqgtkrsVFKALFQGKTARITVLLWLLyfmLLVGVYFLTNWLPKLMVEL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 266 VGLPKEVVSW-INFVALLIFVVLqpIAGLLSDKIGRRPllMAFGILGTLLTAPIFFFMEktTEPIVAFLLMMVGLIIVTG 344
Cdd:TIGR00895 281 GFSLSLAATGgALFNFGGVIGSI--IFGWLADRLGPRV--TALLLLLGAVFAVLVGSTL--FSPTLLLLLGAIAGFFVNG 354
|
330 340 350
....*....|....*....|....*....|....*.
gi 446002013 345 YTSINAIVKAELFPTEIRALGVGLPYAL--TVAIFG 378
Cdd:TIGR00895 355 GQSGLYALMALFYPTAIRATGVGWAIGIgrLGAIIG 390
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
60-428 |
1.28e-15 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 78.41 E-value: 1.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 60 VGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESiGIMAPIILVLARLLQGLSLGGEYGTSATYLS 139
Cdd:COG2211 58 WDAITDPLIGALSDRTRTRWGRRRPWILIGAIPLALSFVLLFTAPDLS-PTGKLIYALVTYLLLGLAYTLVNIPYSALGA 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 140 EMASSGR-RGFYSSFQYVTLVAGQMVALGVQIVLQQLLSEpdMKAWGWRIPFIIGA-MGAVAVLWLRRTMDESEQFSNIK 217
Cdd:COG2211 137 ELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGG--DAALGYRLTALIFAvLGLLAFLLTFFGTKERPVPEEEK 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 218 SQKRESAGTVRalmkHPKAVLTVVGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDK 297
Cdd:COG2211 215 VSLKESLKALL----KNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 298 IGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMM---VGLIIVTGYTSINAIVKAELFPTEIRA---------LG 365
Cdd:COG2211 291 FGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAgigLGAILVLPWAMLADVVDYDEWKTGRRReglyfgiftFA 370
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446002013 366 VGLPYALTVAIFGGTAEFIALWLKSI-------GMESLFYFYVAGCIAISFITYWRMDESSKT-SQIEAEL 428
Cdd:COG2211 371 IKLGQALAGALAGLLLALFGYVAGAAqspsaltGIRLLFFLLPAVLLLLAALLLLFYPLTRERhAEIRAEL 441
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
25-412 |
1.56e-15 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 77.70 E-value: 1.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 25 YDWYVYSAFAVYFSAEFFPKGDPTSQLLnTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPS 104
Cdd:cd17364 13 YDLFSISLVTKILGRLYYGGKGSLPSGV-SGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 105 YESIGIMAPIILVlaRLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLLSEPDMKAW 184
Cdd:cd17364 92 STPLGVMGWLIFF--RFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 185 ------GWRIPFIIGAMGAVAVLWLRRTMdeseqfsniksqkresagtvralmkhpkavltvVGLTLGG---TVAFYTYT 255
Cdd:cd17364 170 yhhadlVWRIVLGLGAIPALSVLYFRKHL---------------------------------LGTAGTWfllDIAFYGQN 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 256 TYlQKFMVNTVGLPK---------EVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMA-FGILGTLLTAPIFFFMEKT 325
Cdd:cd17364 217 LF-QSTIISAIGFSKtmnayqelfNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMgFFGMTIFLLILAGPYDHWK 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 326 TEPIVAFLL-MMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYAL--TVAIFGGtaeFIALWL-KSIGMESLFYFYV 401
Cdd:cd17364 296 ISTIGFFVLyGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASgkIGAIVGS---FLFLSLtQNIGVRNVLIILA 372
|
410
....*....|.
gi 446002013 402 AGCIAISFITY 412
Cdd:cd17364 373 GVALLGIILTL 383
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
66-412 |
1.78e-14 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 74.92 E-value: 1.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 66 PIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYEsigimapiILVLARLLQGLSLGGEYGTSATYLSEMASSG 145
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVW--------MLYLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 146 RRGFYSSFQYVTLVAGQMVALGVQIVLqqllsepdmkawGWRIPFIIGAMGAVAVL------------------------ 201
Cdd:cd17358 127 VRGALGSLNQLLVNIGILLGYVLGSFL------------PWRTLALIGAIPPVVFLillffipesprwlakkgreeeaek 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 202 ---WLRRT-MDESEQFSNIKSQKRESAGTVRA----LMKHP---KAVLTVVGLT----LGGTVAFYTYTTylQKFMVNTV 266
Cdd:cd17358 195 slqFLRGKdADISKEAAEIQEELAELEKEAKEssfsDLFQRkylKPLVIGLGLMlfqqLSGINAVIFYAS--SIFDEAGS 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 267 GLPKEVVSWINFVALLIFVVlqpIAGLLSDKIGRRPLLMAFGI---LGTLLTApIFFFMEKTTE-----PIVAFLLMMVG 338
Cdd:cd17358 273 GLDPNTATIIIGVVQVVGTL---VATLLVDRLGRRPLLLVSAIgmgIGLLALG-LYFYLQEHGAllssvSWLPLVGLVIY 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 339 LIIVT-GYTSINAIVKAELFPTEIRALGVGLpyaltVAIFGGTAEFIALWL-----KSIGMESLFYFYVAGCIAISFITY 412
Cdd:cd17358 349 IISFSiGLGPLPWVIMSEIFPAKIKGLAGSL-----VTLVNWLFAFIVTKTfpfltLAWGASGTFWIFAGICGLALVFVL 423
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
57-367 |
2.29e-14 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 73.77 E-value: 2.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 57 IFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESigimapiiLVLARLLQGLSLGGEYGTSAT 136
Cdd:cd17365 39 VGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ--------LALLRFLTGLGLGAAMPNAIT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 137 YLSEMASSGRRGFYSSFQYVTLVAGQMVAlgvqivlqQLLSEPDMKAWGWRIPFIIGAMGAVAVLwlrrtmdeseqfsni 216
Cdd:cd17365 111 LVSEYAPARRRSLAVTLMFCGYPLGAALG--------GFLAAALIPAFGWRSVFLLGGVPPLILL--------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 217 ksqkresagtvralmkhpkaVLTVVGLTLGGT-----VAFYTYTTYLQKFMVnTVGLPKEVVSWINFVALLIFVVLQPIA 291
Cdd:cd17365 168 --------------------PLLRGTLLLWVTffmglLLVYLLNSWLPKLMV-EAGYSLSQALTITLLLNIGGVIGSLLL 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446002013 292 GLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTtePIVAFLLMMVGLIIVTGYTSINAIVkAELFPTEIRALGVG 367
Cdd:cd17365 227 GWLADRFGPKRVLALFFALGAVSLALLGVSPASL--VLLYVLVFLAGACVNGAQVGLYALA-ARFYPTEVRATGVG 299
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
33-388 |
3.39e-14 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 74.19 E-value: 3.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 33 FAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYesigima 112
Cdd:PRK12307 34 FMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGV------- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 113 pIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFqyvtLVAGqmvaLGVQIVLQQLLSEPDMKAWGWRIPFII 192
Cdd:PRK12307 107 -IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAF----LVSG----FGIGNIIAAYFMPSFAEAYGWRAAFFV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 193 GAMGAVAVLWLRRTMDESEQFSNIK---------SQKRESAGTVRALMKHPKAVLT----VVGLTLGGT--VAFYTYTTY 257
Cdd:PRK12307 178 GLLPVLLVIYIRARAPESKEWEEAKlsgkgkhsqSAWSVFSLSMKGLFNRAQFPLTlcvfIVLFSIFGAnwPIFGLLPTY 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 258 LQKFMVNTVglpkeVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVA--FLLM 335
Cdd:PRK12307 258 LAGEGFDTG-----VVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNYLLLGAclFGLM 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446002013 336 MVGLiivtGYTSINAIVKAELFPTEIRALGVGLPYALTvAIFGGTAEFIALWL 388
Cdd:PRK12307 333 ATNV----GVGGLVPKFLYDYFPLEVRGLGTGLIYNLA-ATSGTFNSMAATWL 380
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
57-367 |
4.22e-14 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 73.46 E-value: 4.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 57 IFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESigimapiiLVLARLLQGLSLGGEYGTSAT 136
Cdd:PRK11551 55 AFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 137 YLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIvlqqLLSEPDmkawGWRIPFIIGAMGA-VAVLWLRRTMDESEQFSN 215
Cdd:PRK11551 127 LTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGV----LAAGDA----AWRHIFYVGGVGPlLLVPLLMRWLPESRAFAQ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 216 IKSQKRESAGTVRALMKHPKAVLTVVGLT--LGGTVAFYTYTTYLQKFMVNTvGLPKEVVSWINFV--------ALLIfv 285
Cdd:PRK11551 199 AAGAGKQRAPVLRALFGEGRATATLLLWIsyFFTLIVLYFLLNWLPSLLVGQ-GLSRSQAGLVQIAfniggalgSLLI-- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 286 vlqpiaGLLSDKIGRRP--LLMAFGILGTLL---TAPIFFFMEkttepIVAFLLmmvGLIIVTGYTSINAIVkAELFPTE 360
Cdd:PRK11551 276 ------GALMDRLRPRRvvLLIYAGILASLAalaAAPSFAGML-----LAGFAA---GLFVVGGQSVLYALA-PLFYPTQ 340
|
....*..
gi 446002013 361 IRALGVG 367
Cdd:PRK11551 341 VRGTGVG 347
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
55-346 |
1.01e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 72.21 E-value: 1.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 55 AAIFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSyesigimaPIILVLARLLQGLSLGGEYGTS 134
Cdd:cd17477 37 ASAYYLGIL---LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 135 ATYLSEMASSGRRG----FYSSFQYVTLVAGQMVALGVQIVLQQLLSepdmkawgwrIPFIIGAMGAVAVLWLRRtmdes 210
Cdd:cd17477 106 ESWLNALATNENRGrvlgLYSTVLGLGFALGPLLLALVGTAGALPFL----------IAAVLLLLALVPLLLTRR----- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 211 eqfSNIKSQKRESAGTVRALMKHPKAVLTVV--GLTLGGTVAFYTYttYLQKfmvntVGLPKEVVSWINFVALLIFVVLQ 288
Cdd:cd17477 171 ---AAPEIEEAESISLRRLLRIAPLALLGAFvaGFLEGAFYSLLPL--YGLR-----LGLSVAQAALLLAAFVLGGLLLQ 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 446002013 289 PIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMekTTEPIVAFLLMMVGLIIVTGYT 346
Cdd:cd17477 241 WPLGWLADRFDRRRVLLGCALLGALAALLLPLVP--GLPLALLVLLFLWGGAAGPLYT 296
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
47-413 |
1.36e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 71.81 E-value: 1.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 47 PTSQLLNTAAIFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYesigimapIILVLARLLQGLS 126
Cdd:COG0738 41 SDAQAGLLLFAFFLGYL---LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 127 LGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLLSepdmkaWGWRIPFII--GAMGAVAVLWLR 204
Cdd:COG0738 110 LGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLS------LSWHLPYLIlaVLLLLLALLFLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 205 RTMDESEQfsnIKSQKRESAGTVRALMKHPKAVLTVVGLtLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIF 284
Cdd:COG0738 184 SKLPEIEE---EEEEAAGSAASLKSLLKNPRLLLGGLAI-FLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGM 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 285 VVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFmekTTEPIVAFLLMMVGLIIVTGYTSINAIVkAELFPTEIRAL 364
Cdd:COG0738 260 TIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLA---PGPWLALIGLALVGLGLSLMFPTIFSLA-LDGLGKRTAAA 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446002013 365 GVGLpyaLTVAIFGGTA--EFIALWLKSIGMESLFYFYVAGCIAISFITYW 413
Cdd:COG0738 336 VSAV---LIMGIVGGAIgpPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
51-415 |
1.79e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 68.37 E-value: 1.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 51 LLNTAAIFAVGFLMRPIGSLlmgryADRHGRRAALTLSITVMAGGSLIIACTPSYEsigimapiILVLARLLQGLSLGGE 130
Cdd:cd17474 38 LLITAFTLPAAVLMPVAGVL-----ADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 131 YGTSATYLSEMASSGRRGfyssfqyvTLVAGQMVALGVQIVLQQLLSEPdMKAWGWRIPFIIGAMGAVAVLWLRRTMDES 210
Cdd:cd17474 105 GPLALTLIGDLFEGGERA--------KAMGLYEAALGLGIAVGPLLGGL-LAAISWRYPFFLLAALIPVAFLAILFLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 211 EQFSNIKSQKRESAGTVRALmkHPKAVLTVVGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPI 290
Cdd:cd17474 176 PKEKAKSSSATKLRDLKKAL--RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 291 AGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMekTTEPIVAFLLMMVGLIIVTGYTSINAIVkAELFPTEIRALGVGLpY 370
Cdd:cd17474 254 VGRLLKKRFGARRILVIGLLLYALSLLLLGFV--PSLALLLIAIVLFGLGLGLNLPLLTTLV-TELAPEEERGTASSL-Y 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446002013 371 ALTVAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAISFITYWRM 415
Cdd:cd17474 330 NFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
55-412 |
3.00e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 67.58 E-value: 3.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 55 AAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYesigimaPIILVLArLLQGLSLGGEYGTS 134
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY-------WLLLLLV-ALAGIGSAAFHPEG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 135 ATYLSeMASSGRRGFYSSFqyvTLVAGQM-VALGvQIVLQQLLSEPDMKAWGWripFIIGAMGAVAVLWLRRtmdeSEQF 213
Cdd:cd17478 106 ARLAS-QAAGGRRGLAMSI---FSVGGNLgFALG-PLIAAALVALFGGLGLLI---LLIIPGLAVALLLLRL----RPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 214 SNIKSQKRESAGTVRALMKHPKAVLTVVGLTLGGTVAFYTYTTYLqKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGL 293
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFL-PFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 294 LSDKIGRRPlLMAFGILGTLLTAPIFFFmektTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPtEIRALGVGLPYALT 373
Cdd:cd17478 253 LSDRFGRRR-VIIASLLLAAPFLLLFLL----TPGIWSYILLVLAGFLLFASFPVTVVLAQELLP-GNVGLASGLMMGLS 326
|
330 340 350
....*....|....*....|....*....|....*....
gi 446002013 374 VAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAISFITY 412
Cdd:cd17478 327 FGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
3-372 |
1.67e-11 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 65.91 E-value: 1.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 3 QVKSNRVAGnifkgsVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNtAAIFAVGFLMRPIGSLLMGRYADRHGRR 82
Cdd:TIGR00887 14 HFRAIVIAG------VGFFTDSYDLFCISLVTKMLGYVYYHGKGPLPSSVS-AAVNGSASIGTLAGQLFFGWLADKLGRK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 83 AALTLSITVMAGGSLIIACTPSYESIGIMAPIILVlaRLLQGLSLGGEYGTSATYLSEMASSGRRGFYSS----FQYVTL 158
Cdd:TIGR00887 87 RVYGMELIIMIIATVASGLSPGSSPKSVMATLCFW--RFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAavfaMQGFGI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 159 VAGQMVALGVQIVLQQLLSEPDMKA-----------WGWRIPFIIGAMGAVAVLWLRRTMDESEQFSNI----------- 216
Cdd:TIGR00887 165 LAGAIVALIVLAGFKHSLEAAADEAsctgscvpavdYMWRILIGFGAVPALLALYFRLTIPETPRYTADvakdveqaasd 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 217 --KSQKRESAGTVRALMKHPKAVLTVV---------------GLTLGGT--------VAFYTYTTYlQKFMVNTVG--LP 269
Cdd:TIGR00887 245 msAVLQVKIEAEPDEVEKASTAVEVPKaswsdffthffkwrhGKHLLGTagswflldIAFYGVNLN-QKVILSAIGysPP 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 270 KEVVSWINF-----VALLIFVVLQPIAG-----LLSDKIGRRPL-LMAFGILGTLLTAPIFFFMEKTTEPIVAfLLMMVG 338
Cdd:TIGR00887 324 AATNNAYEElyktaVGNLIIALAGTVPGywvtvFLVDIIGRKPIqLMGFFILTVLFFVLGFAYNHLSTHGFLA-IYVLAQ 402
|
410 420 430
....*....|....*....|....*....|....
gi 446002013 339 LIIVTGYTSINAIVKAELFPTEIRALGVGLPYAL 372
Cdd:TIGR00887 403 FFANFGPNATTFIVPGEVFPTRYRSTAHGISAAS 436
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
39-407 |
3.63e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 64.52 E-value: 3.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 39 AEFFPKGDPT--SQLLNTAAIFAVgflmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESIgimapiil 116
Cdd:cd17473 26 AQHFVPNSELlvPLLLTLPALFIA------LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL-------- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 117 VLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLlsepdmkawGWRIPFIIGAMG 196
Cdd:cd17473 92 LASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI---------GWRAPFLVYLLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 197 ----AVAVLWLRRTMDeseqfsniKSQKRESAGTVRALMKHPKAVLTVVGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEV 272
Cdd:cd17473 163 lpvlILVLLFLPEPAR--------KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAAL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 273 VSWinfvALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMMV-----GLIIVTGYTS 347
Cdd:cd17473 235 IGL----ALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILaglgfGLLLPTLNSW 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446002013 348 INAIVkaelfPTEIRALGVGLpyaLTVAIFGG--TAEFIALWLKSIGMESLFYFYVAGCIAI 407
Cdd:cd17473 311 AMSLV-----PPELRGRAMGI---VTSAFFLGqfLSPLVLGPLVNLTGGLSGAFLILGVLAL 364
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
26-368 |
6.23e-11 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 63.37 E-value: 6.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 26 DWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSY 105
Cdd:cd17317 2 WEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVL---IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 106 EsigimapiILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQllsepdmkawg 185
Cdd:cd17317 79 E--------LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD----------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 186 WRIPFIIGAMGAVAVLWLrrtmdeseqfsniksqkresagtvraLMKHPKaVLTVVGLTLGGT-VAFYTYTTYLQKFMVN 264
Cdd:cd17317 140 WRWLQLAISLPGLLFLLL--------------------------LWWLPR-RTIIVGLIWFVTsLVYYGLSLNSSNLGGN 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 265 TVglpkevvsWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKttEPIVAFLLMMVGLIIVTG 344
Cdd:cd17317 193 LY--------LNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDD--ENTLALTLALVGKFAISA 262
|
330 340
....*....|....*....|....
gi 446002013 345 YTSINAIVKAELFPTEIRALGVGL 368
Cdd:cd17317 263 AFSVIYLYTAELYPTVVRNTGVGL 286
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
53-368 |
7.03e-11 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 63.88 E-value: 7.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 53 NTAAIFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYesigimaPIILVLaRLLQGLSLGGEYG 132
Cdd:TIGR00898 131 LTQSCFFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY-------TVFLVF-RLLVGMGIGGIWV 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 133 TSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQllsepdmkawgWR-------IPFIIgamGAVAVLWL-- 203
Cdd:TIGR00898 200 QAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD-----------WRwlqlavsLPTFL---FFLLSWFVpe 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 204 --------------RRTMDE---------SEQFSNIKSQKRESAGTVRALMKH-------PKAVLTVVGLTLGGTVAFYT 253
Cdd:TIGR00898 266 sprwlisqgrieeaLKILQRiakingkklPAEVLSLSLEKDLSSSKKQYSFLDlfrtpnlRKTTLCLMMLWFTTAFSYYG 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 254 YTTYLQKFMVNtvglpkevVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTtePIVAFL 333
Cdd:TIGR00898 346 LVLDLGNLGGN--------IYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDL--YFLRTA 415
|
330 340 350
....*....|....*....|....*....|....*
gi 446002013 334 LMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGL 368
Cdd:TIGR00898 416 LAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGV 450
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
47-415 |
8.94e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 63.36 E-value: 8.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 47 PTSQLLNTAAIFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYEsigimapiILVLARLLQGLS 126
Cdd:cd17320 32 SASAVQLTLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIE--------QLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 127 LGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVA--LGVQIvlqqllsepdMKAWGWRIPF-IIGAMGAVAVLWL 203
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAplLGGLL----------LLFFGWRAIFvFLALLGLLLLLLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 204 RRTMDESEQFSNIKSQKRESAGTVRALMKHPKAVLTVVGLTLgGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLI 283
Cdd:cd17320 171 LLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGL-SFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 284 FVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTEIRA 363
Cdd:cd17320 250 LILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446002013 364 LGVGLPYALTVAIFGGTAEFIALWlkSIGMESLFYFYVAGCIAISFITYWRM 415
Cdd:cd17320 330 TASALLGFLQFLIGALAGALVGLL--PNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
48-415 |
5.11e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 60.66 E-value: 5.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 48 TSQLLNTAAIFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESigimapiiLVLARLLQGLSL 127
Cdd:cd17319 37 PTQYGLIASAFFLGYA---LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVAE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 128 GGEYGTSATYLSEMASSGRRGFYSSFQYvtlvAGQMVALgvqiVLQQLLSEPDMKAWGWRIPFIIgaMGAVAVLWLrrtm 207
Cdd:cd17319 106 AGFFPGAIKALAEWFPARERGRATGLFN----SGAPLGA----AIGPPLSGWLLLLFGWRWAFII--EGLLGLLLA---- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 208 deseqfsniksqkresagtVRALMKHPKaVLTVVGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVL 287
Cdd:cd17319 172 -------------------VLWWFYLRQ-VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 288 QPIAGLLSDKI--GRRPLLmafGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTEIRALG 365
Cdd:cd17319 232 MILGGRLSDRLlrGARRLV---IIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATA 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446002013 366 VGLpYALTVAIFGGTAEFIALWLKSI-GMESLFYFYVAGCIAISFITYWRM 415
Cdd:cd17319 309 GGL-INSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
67-410 |
8.34e-10 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 60.06 E-value: 8.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYEsigimapiILVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFYSSFQYVTLVAGqmvalgvqIVLQQLLSEPDMKA-WGWRIPFIIGAMGAVAVLWLRRTMDESEQFSNiKSQKRESAG 225
Cdd:cd17362 126 RGLLVSLKELFIVLG--------ILLGYVSGYAFADVvGGWRYMYGLAAPPALLLGIGMWFLPPSPRWQG-NYRKPLIIG 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 226 TVRALMKHpkavltvvgLTLGGTVAFYTYTTyLQKFMVNTVGLPKEVVSWINFVALLIFVVlqpiAGLLSDKIGRRPLLM 305
Cdd:cd17362 197 LGLVLFQQ---------ITGQPSVLYYAATI-FKSAGFSAASDATLVSVGLGVFKLLMTIV----AVLLVDKLGRRPLLL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 306 A--FGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVTGYT----SINAIVKAELFPTEIRALGVGLPYALTVAIFGG 379
Cdd:cd17362 263 GgvSGMVVSLFLLAAYNLFVQMGPAGLAWLSLVALLLYVGAYQisfgPISWLMVSEIFPLRVRGRAIALAVLVNFGSNAL 342
|
330 340 350
....*....|....*....|....*....|..
gi 446002013 380 TAEFIALWLKSIGMESLFY-FYVAGCIAISFI 410
Cdd:cd17362 343 VSLAFLPLQELIGLPGTFLgFGVIGVLALLFI 374
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
67-368 |
3.45e-09 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 58.18 E-value: 3.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYEsigimapiILVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYP--------VLMVGRFVAGIGVGFALMIAPVYTAEVAPASS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFYSSFQYVTLVAGQMVALGVQIVLQQLLSEpdmkaWGWRIPFIIGAMGAVAVLWLRRTMDESEQFSN---------IK 217
Cdd:cd17437 119 RGFLTSFPEIFINIGILLGYVSNYAFSGLPLH-----VGWRLMLGVGAVPSLFLAIGVLAMPESPRWTPavrrmliaaLG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 218 SQKRESAGTVRALMKHPKAVLTVVGLT-----LGGTVAfytyttylqkfmvntVGLPKevvswinfvALLIFVvlqpiAG 292
Cdd:cd17437 194 IHFFQQASGIDAVVLYSPRIFKKAGIKskdklLLATVA---------------VGVTK---------TLFILV-----AT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 293 LLSDKIGRRPLLM--AFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVT-------GYTSINAIVKAELFPTEIRA 363
Cdd:cd17437 245 FLLDKVGRRPLLLtsTGGMTLSLTALATSLTFIDRNGGGLTWALVLAITAVCSfvaffsiGAGPITWVYSSEIFPLRLRA 324
|
....*
gi 446002013 364 LGVGL 368
Cdd:cd17437 325 QGASL 329
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
67-368 |
3.75e-09 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 58.05 E-value: 3.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPsyesigimAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17360 50 VGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAP--------NKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRI 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFYSSFQYVTLVAGQMVALGVQIVLQQLlsePDmkawGWRIPFIIGAMGAVAVLWLRRTMDESEQFSNiksqkresagT 226
Cdd:cd17360 122 RGRLVTINVLFITGGQFVAYVINGAFSYL---PG----GWRWMLGLAAVPAVLQFIGLLFLPESPRWPS----------T 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 227 VRALmkhpkavltVVGLTLG--------GTVAFYTyTTYLQKFMV---NTVGLPKEVVSWINFVALLIFVVlqpiaglLS 295
Cdd:cd17360 185 RRAL---------IVGCGLQafqqfsgiNTVMYYS-ATILQMAGFkdnQNAIWLSLIVAGTNFIFTIVGMY-------LI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 296 DKIGRRPLLMA--FGILGTLLtapifffmekttepIVAFLLMMVGLII-----VTGYTSINAIVKAELFPTEIRALGVGL 368
Cdd:cd17360 248 DKFGRRKLLLIslFGVIVALV--------------VLAVWLALVGLILylaffAPGMGPVPWTVNSEIYPLWARGTGGGC 313
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
18-390 |
6.10e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 57.63 E-value: 6.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 18 VGNLIEWYDWYVYSAFAVYFSAEFfpKGDPTSQLLNTAAiFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSL 97
Cdd:cd17328 6 LINLLNYMDRFTIAGVLPDIQSDF--LIDDSLAGLLQTV-FIISYM---VLSPIFGYLGDRYNRKWILAVGILIWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 98 IIACTPSYESigimapiiLVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLLS 177
Cdd:cd17328 80 LSSFAPNFWQ--------LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 178 epdmkawGWRIPFII-GAMGAVAVLWLRRTMDE-----SEQFSNIKSQKRESAGTVRALMKHPKAVLTVVGLTL----GG 247
Cdd:cd17328 152 -------GWRWAFRVtGVLGVLLAILLLLFVREpprgaAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAvsfvTG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 248 TVAFYTYTTYLQKFMVNtvGLPKEVVSWINFVALLIFVVLQPIAG-LLSDKIGR-----RPLLMAFgilGTLLTAPIFF- 320
Cdd:cd17328 225 ALAFWAPTFFLRAFGVG--DLSSADVGLIFGAITCIAGVLGVLLGgILADRLRRktpraDPLVCAV---GLLAAAPFLFl 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446002013 321 -FMEKTTEPIVAFLLmmvGLIIVTGYTSINAIVKAELFPTEI---RALGVGLpYALTVAIFGGTAEFIALWLKS 390
Cdd:cd17328 300 aLVLALSNLLLAWVL---LFLGEFLLSLNWAPVFAILLYVVIptrRSTASAI-QILLSHLLGDAGSPYLIGLIS 369
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
54-360 |
2.60e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 52.27 E-value: 2.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 54 TAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSyesigimAPIILVLARLLQGLSLGGEYGT 133
Cdd:cd17355 40 ISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATS-------LWQLYLLWGLLGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 134 SATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGvqiVLQQLLSepdmkAWGWRIPFIIGAMGA------VAVLWLRRTM 207
Cdd:cd17355 113 AFATVAAWWFERRRGLALGILTAGGGLGSLVFLP---LGAALIE-----AFGWRTALLVLALLAllvlvpVLLLLRRRPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 208 DESEQFSNIKSQkRESAGTVRALMKHPKAVLTVVGLTLGGtVAFYTYTTYLQKFMVNtVGLPKEVVSWInfVALLIF--V 285
Cdd:cd17355 185 DLALRAYDDASP-ASPGSTLKEALRSASFWLLALAFFLCG-FAVVGLIVHLVPYLAD-RGISPAAAAVA--LALIGLfnI 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446002013 286 VLQPIAGLLSDKIGRRPLLMAFGILGTLLTApiFFFMEKTTEPIVAFLLMMVGLiIVTGYTSINAIVKAELFPTE 360
Cdd:cd17355 260 VGRLLSGWLGDRYSPRRLLAASYALRALGLA--LLLLLPFPPLALLLFAALFGL-GWGATVPLTAALAARYFGAR 331
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
238-415 |
9.27e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 50.64 E-value: 9.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 238 LTVVGLTLGGTVAFYTYTT--YLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLT 315
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNlsVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 316 APIFFFmekTTEPIVAFLLMMVGLIIVTGYTSINAIVkAELFPTEIRALGVGLpYALTVAIFGGTAEFIALWL-KSIGME 394
Cdd:COG2271 90 LLFGFA---TSFWQLLLLRFLLGLGEAGFFPAALKLI-AEWFPPKERGRALGI-FNAGGPLGGALAPPLLGWLlAAFGWR 164
|
170 180
....*....|....*....|.
gi 446002013 395 SLFYFYVAGCIAISFITYWRM 415
Cdd:COG2271 165 AAFLILGLPGLLLALLRFWLL 185
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
49-368 |
9.55e-07 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 50.37 E-value: 9.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 49 SQLLNTAA--IFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYEsigimapiILVLARLLQGLS 126
Cdd:cd17374 33 SQSLKSVAqsIFMAGLL---VGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFP--------VYCVLRFLAGFA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 127 LGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQllsepdmkawgWRIPFIIGAMGAVAVLWLRRT 206
Cdd:cd17374 102 VSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRD-----------WRLLQLVVSVPFFLFFLYSWW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 207 MdeseqfsniksqkresagtvralmkhPKAVLTVVGLTLGGTVAFYTYTTYLQKFMVNtVGLPKEVVSWINFVA-LLIFV 285
Cdd:cd17374 171 L--------------------------PKRTLILSFVWFANSFSYYGLSLDLQHLGLN-VFLLQFLFGAVEVPArCLALF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 286 VLQpiagllsdKIGRRPLLMAFGIL-GTLLTAPIFFFMEkttEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTEIRAL 364
Cdd:cd17374 224 LLN--------HMGRRISQAVLLLLaGLCILANIFVPQE---MQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQT 292
|
....
gi 446002013 365 GVGL 368
Cdd:cd17374 293 GMGL 296
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
245-349 |
1.36e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.29 E-value: 1.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 245 LGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSD----KIGRRPLLMAFGILGTLLTAPIFF 320
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPLALSFVLLF 99
|
90 100
....*....|....*....|....*....
gi 446002013 321 FMEKTTEPIVAFLLMMVGLIIVTGYTSIN 349
Cdd:COG2211 100 TAPDLSPTGKLIYALVTYLLLGLAYTLVN 128
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
67-378 |
1.37e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 50.31 E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESigimapiiLVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV--------LLVLLFLVGAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFYSSFQyvtlvagQMvALGVQIVLQQLLSEPDMKAWGWRIPFIIGA-----MGAVAVLWLRrtmdESEQFSNIKSQKR 221
Cdd:cd17475 118 RGLAMGIR-------QT-GVPLGGALAAALLPPLALHYGWRAAFVVAGlvsilAAVLFWLFYR----EPPAASAATESAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 222 ESAGTVRALMKHPKAVL-TVVGLTLGGtvAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIG- 299
Cdd:cd17475 186 TLLRSLKEVLRNRDVWLiAIAGALLVA--PQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFg 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 300 --RRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVtGYTSINAIVKAELFPTEIRALGVGLpyALTVAIF 377
Cdd:cd17475 264 grRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAI-GWNGLYLTLVAESAGPEQAGTALGL--ANTINFI 340
|
.
gi 446002013 378 G 378
Cdd:cd17475 341 G 341
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
51-334 |
1.45e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 50.26 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 51 LLNTAAIFAVGflmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYesigimapIILVLARLLQGLSLGGE 130
Cdd:COG2807 57 LLTTLPLLAFG-----LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV--------ALLLAGTALIGAGIAVG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 131 YGTSATYLSEMASSgRRGFYSSFQYVTLVAGQMVALGVQIVLQQllsepdmkAWGWRIPFIIGAMGAV--AVLWLRRTMD 208
Cdd:COG2807 124 NVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAA--------ALGWRGALAVWALLALlaLLLWLPLLRR 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 209 ESEQfsnikSQKRESAGTVRALMKHPKAVLTVVGLTLgGTVAFYTYTTYLQKFMVNTvGLPKEVVSWINFVALLIFVVLQ 288
Cdd:COG2807 195 RPAA-----AAAAPAAASLRSLWRSPLAWLLTLFFGL-QSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGS 267
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 446002013 289 PIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLL 334
Cdd:COG2807 268 LLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLL 313
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
70-339 |
1.61e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.86 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 70 LLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSyesigimaPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRR-- 147
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRgr 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 148 --GFYSSFQYVTLVAGQMVAlGVqivlqqLLSepdmkAWGWRIPFIIGAMGAVAVLWLRRTmdeseqFSNiksqkresag 225
Cdd:cd17321 121 alGLWGAVVGIGAALGPLLG-GL------LLE-----LFGWRWIFLINVPIGLVALLLART------FSG---------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 226 tvralmkhpkAVLTVVGLTLGGTVAFYTYTTYLQkfmvNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLM 305
Cdd:cd17321 173 ----------AVLAAFLLGAALGGLLFLLPLYLQ----GVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238
|
250 260 270
....*....|....*....|....*....|....
gi 446002013 306 AFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGL 339
Cdd:cd17321 239 AGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGL 272
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
32-412 |
3.37e-06 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 49.17 E-value: 3.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 32 AFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMrpiGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACtpSYESIGIm 111
Cdd:cd17356 28 SFQKYFADNTGTYYPSSSRQGLIVSIVNLGSFF---GALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVA--AIGKWYQ- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 112 apiiLVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLLSEpdmkAWgWRIPFI 191
Cdd:cd17356 102 ----LIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGS----AQ-WRIPLG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 192 IGAMGAVAVL-----------WLRRTMdeseqfsniksqkreSAGTVRALMKhpkavltvvgltLGGTVAFYTYTTYlqk 260
Cdd:cd17356 173 LQIVWGLLLLigmfflpesprWLYRTI---------------LGIMLQLFQQ------------LTGINYFFYYGTT--- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 261 fMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLL-----------MAFGILGTLLTAPIFFFMEKTTEP- 328
Cdd:cd17356 223 -IFQSTGLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLligaagmsiclFIYAAVGVRYLIPNPQSGTSNKSAg 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 329 --IVAFLLMMVGlIIVTGYTSINAIVKAELFPTEIRALGVGLpyaltVAIFGGTAEFIALWLKSIGMESL----FYFYVA 402
Cdd:cd17356 302 ngMIVFICLFIF-SFATTWGPIAWVYVAEVFPLRVRSKGMAL-----ATAFNWLWNFLISFFTPFIIGSIgfkyYYIFAG 375
|
410
....*....|
gi 446002013 403 GCIAISFITY 412
Cdd:cd17356 376 CNLLAFIVVF 385
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
54-410 |
3.56e-06 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 49.15 E-value: 3.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 54 TAAIFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIAC---TPSYEsigimapiILVLARLLQGLSLGGE 130
Cdd:cd17432 55 TVSIFPLGGL---FGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLskiAKSFE--------MIIVGRFLVGINAGIS 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 131 YGTSATYLSEMASSGRRGFyssfqyVTLVAGQMVALGV---QIV-LQQLLSEPDmkawGWriPFIIGAMGAVAVL----- 201
Cdd:cd17432 124 LNVVPMYLGESAPKNLRGA------VGLVPAIFITLGIllgQVLgLRELLGNEE----GW--PLLLALTGVPALLqlltl 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 202 -------------------------WLRRTMDESEQFSNI----KSQKRESAGTVRALMKHPKA---VLTVV----GLTL 245
Cdd:cd17432 192 pffpesprylliekgdeeaarkalqRLRGKEDVDDEMEEMleeqRAEKGVGTVSVLELFRDRSVrwqLISIIvlmaGQQL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 246 GGTVAFYTYTTYLQKfmvnTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMA-FGILGTLLTAPIFFFMEK 324
Cdd:cd17432 272 CGINAIYFYADSIFL----EAGIPEDKIQYVTVGTGACEVLATITCVLVIERLGRRPLLIGgFGLMAVWCAVLTVALSLQ 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 325 TTEPIVAFLLMMVGLIIVTGYTS----INAIVKAELFPTEIRalgvglPYALTVAifgGTAEFIALWLksIGMesLFYFY 400
Cdd:cd17432 348 NTVSWMPYLSIVCIFAYIASFGIgpagVPFILTTEIFDQSSR------PAAFMVA---GSLNWLSNFL--VGL--LFPFI 414
|
410
....*....|
gi 446002013 401 VAGCIAISFI 410
Cdd:cd17432 415 QEGLGAYCFL 424
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
67-410 |
4.77e-06 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 48.64 E-value: 4.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYesigimapIILVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17436 51 LASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSF--------FWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFYSSFQYVTLVAGQMVALGVQIVLQQLlsepdmkAWGWRIPF----IIGAMGAVAVLWLRRTMDESEQFSNIKSQkre 222
Cdd:cd17436 123 RGLLVSLYEAGITVGILISYALNYFFSNV-------LTGWRYMFglaiIPAAIQFASILLLPKKPEVLNIKDNMRRR--- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 223 sagtvralmkhpkavlTVVGLtlgGTVAFYTYT-----TYLQKFMVNTVGLPKEVVSWINFVAL-LIFVVLQPIAGLLSD 296
Cdd:cd17436 193 ----------------TLVGL---GLVLFQQFTgqpnvLCYASTIFRSVGFQSNSSAVLASVGLgVVKVIATLLAMLFAD 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 297 KIGRRPLLMAFGILGTLLTAPIFFFmekttepiVAFLLMMVGLIIVT-GYTSINAIVKAELFPTEIRalgvGLPYALTVA 375
Cdd:cd17436 254 RAGRRSLLIAGCSVMAVSVSGIGLW--------ITLLCLMAFVSAFSiGFGPMTWLVLSEIYPADIR----GRAFSFCNS 321
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446002013 376 IFGGTAEFIAL----WLKSIGMESLFYFY-VAGCIAISFI 410
Cdd:cd17436 322 FNWAANLLITLsfldLIDVIGLSWTFLLYgVVGVAGVVFI 361
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
48-351 |
6.49e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.96 E-value: 6.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 48 TSQLLNTAAIFAVGfLMRPIGSLLmgryADRHGRRAALTLSITVMAGGSLIIACTPSYESigimapiiLVLARLLQGLSL 127
Cdd:cd17503 32 TVQWVITSYLLALA-IMIPLSGWL----ADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 128 GGEYGTSATYLSEMASSGRRGFYSSFqyVTLVAgqMVALGVQIVLQQLLSEpdmkAWGWRIPFIIGAMGAVAVLWLRRTM 207
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGL--VGLVI--LLAPAIGPTLGGWLTD----NLSWRWIFYINLPIGILALLLAPLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 208 DESeqfsniksqkresagtvraLMKHPKAVLTVVGLTLGGtVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVL 287
Cdd:cd17503 171 DLR-------------------LFKDRNFTLGLLLSFLLG-LGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAIL 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446002013 288 QPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVTGYTSINAI 351
Cdd:cd17503 231 SPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTL 294
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
56-227 |
1.01e-05 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 47.72 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 56 AIFAVGFLmrpIGSLLMGRYADRHGRRAALTLS-ITVMAGGSLIIAC--TPSYEsigimapiILVLARLLQGLSLGGEYG 132
Cdd:cd17431 57 AIFSVGGM---IGSFSVGLFVNRFGRRNSMLYNnLLAFAGAALMGLSklAKSYE--------MLILGRFIIGLYCGLTTG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 133 TSATYLSEMASSGRRGFYSSFQYVTLVAGQMVAlgvQIV-LQQLLSEPDMkaWgwriPFIIGAMGAVAVLWLRRTM--DE 209
Cdd:cd17431 126 LVPMYIGEISPTALRGALGTLHQLGIVVGILIS---QIFgLEFILGTEEL--W----PLLLGFTIVPAILQLALLPfcPE 196
|
170
....*....|....*...
gi 446002013 210 SEQFSNIKSQKRESAGTV 227
Cdd:cd17431 197 SPRYLLINRNEEEEAKSV 214
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
27-344 |
2.25e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 46.48 E-value: 2.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 27 WYVYSAFAVYFSAEFfpkGDPTSQLLNTAAI-FAVGFLMRpigsLLMGRYADRHGRRAALTLSITVMAGGSLIIActpsy 105
Cdd:cd17341 15 WFLFAPLGPVIRDDL---GLSTSQIGLLVAIpVLAGALLR----LPYGFLCDRFGGRRVFIASLLLLLIPLLALA----- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 106 esIGIMAPIILVLARLLQGLSlGGEYGTSATYLSEMASSGRRGFYSSFQYVtlvAGQMVALGVQIVL----QQLLSEPDM 181
Cdd:cd17341 83 --LAVSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAG---AGNMGVAVSQLLApliaGAIVFDGGF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 182 KAWGW--RIPFIIGAMGAVAVLWLRRTMDESeqfsniKSQKRESAGTVRALMKHPKAVLTVV--GLTLGGTVAFytyTTY 257
Cdd:cd17341 157 VGWRNafFVPGILLAIAAVLVLLFGDDLPTG------KASALEFLKVQLAVLKNYRTWILSLlyGVTFGSFVGF---SNV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 258 LQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMMV 337
Cdd:cd17341 228 LPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFV 307
|
....*..
gi 446002013 338 GLIIVTG 344
Cdd:cd17341 308 ALGLGAG 314
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
66-333 |
2.31e-05 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 46.24 E-value: 2.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 66 PIGSLLMGRYADRHgrraALTLSITVMAGGSLIIACTPSYEsigimapiILVLARLLQGLSLGGEYGTSATYLSEMASSG 145
Cdd:PRK10091 56 PIIALFSSRYSLKH----ILLFLVALCVIGNAMFTLSSSYL--------MLAIGRLVSGFPHGAFFGVGAIVLSKIIKPG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 146 RrgfySSFQYVTLVAGQMVALGVQIVLQQLLSEpdmkAWGWRIPFIIGAMGAVAVL---WLRRTMDESEQFSNIKSQKRe 222
Cdd:PRK10091 124 K----VTAAVAGMVSGMTVANLLGIPLGTYLSQ----EFSWRYTFLLIAVFNIAVLasiYFWVPDIRDEAKGGLREQFH- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 223 sagtvraLMKHPKAVLtVVGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGrrP 302
Cdd:PRK10091 195 -------FLRSPAPWL-IFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMMLVGLGMVLGNLLSGRLSGRYS--P 264
|
250 260 270
....*....|....*....|....*....|....
gi 446002013 303 LLMAF---GILGTLLTAPIFFFMEKTTEPIVAFL 333
Cdd:PRK10091 265 LRIAAvtdFIIVLALLMLFFFGGMKTASLIFAFI 298
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
48-414 |
3.84e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.68 E-value: 3.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 48 TSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESIGImaPIILVLArLLQGLSL 127
Cdd:cd06173 30 TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSL--WLLLVLA-FLLGIAS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 128 GGEYGTSATYLSEMASSGRR----GFYSSFQYVTLVAGQMVAlGVQIVLqqllsepdmkaWGWRIPFIIGA----MGAVA 199
Cdd:cd06173 107 AFFGPARQALLPELVPKEQLvranALNSLATQLARIIGPALG-GLLVAL-----------LGPGGAFAINAlsflLSALL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 200 VLWLRRTMDESEQFSNIkSQKRESAGTVRALMKHPKAVLTVVGLTLGGTVAFyTYTTYLQKFMVNTVGLPKEVVSWINFV 279
Cdd:cd06173 175 LLFIRRPPPAAPGESSS-LLLRDLREGLRYLRRSPLLRLLLLALALFALLGG-ALTVLLPLLAKEVLGGGAAGYGLLLAA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 280 ALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFmekTTEPIVAFLLMMVGLIIVTGYTSINAIVkAELFPT 359
Cdd:cd06173 253 FGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS---PSLWLLLAALFLLGLAGGLFNVPLNTLL-QLRVPD 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446002013 360 EIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAISFITYWR 414
Cdd:cd06173 329 ELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
77-345 |
6.39e-05 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 44.91 E-value: 6.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 77 DRHG------RRAALTLSITVMAGGSLIIACTPSYESIGIMAPIILVLARL--LQGLSLGGeygtsatYLSEMASSGRRG 148
Cdd:cd17485 55 DRYGlprlgrRRSWLLPTQLGLALLLLALAFLPPTTNLLAFLGLLFLLNLFsaTQDIATDG-------LAVELLTPEERG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 149 FYSSFQYVTLVAGQMVALGVQIVLQQLlsepdmkaWGWRIPFIIGA----MGAVAVLWLRRtmDESEQFSNIKSQKRESA 224
Cdd:cd17485 128 LGNAAQVVGYKLGSLLGGGGLLWLYDL--------IGWQSLLLSLAalylLLLLPVLFLRE--LELPQQPPASERGAALK 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 225 GTVRALMKHPKA---VLTVVGLTLGGTVAFYTYTTYL--QKFMVNTVGLpkeVVSWINFVALLIFVVLqpiAGLLSDKIG 299
Cdd:cd17485 198 ASLRAFLRRPGTrwlLLFLLLYKLGEQGALAMLPPFLvdRGFSLSQIGL---LSGVGGSLVSIAGSLL---GGYLLKRRG 271
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 446002013 300 RRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVTGY 345
Cdd:cd17485 272 RRRLLLLGGLLRLLLLGLYTLLALGGSGLNWVLLLASLALLHLVGG 317
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
261-372 |
1.05e-04 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 44.58 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 261 FMVNTVGLPKEVVS------WINFVALLIFVVLQP---IAGLLSDKIGRRPLLMAFGILGTLltaPIFFFMEKTTEPIVA 331
Cdd:TIGR01299 576 FLHNKEGCPIDFDGddegayMIYFVNFLGTLAVLPgniVSALLMDKIGRLRMLAGSMVLSCI---SCFFLSFGNSESAMI 652
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446002013 332 FLLMMVGLIIVTGYTSINaIVKAELFPTEIRALGVGLPYAL 372
Cdd:TIGR01299 653 ALLCLFGGLSIAAWNALD-VLTVELYPSDKRATAFGFLNAL 692
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
67-386 |
1.26e-04 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 44.14 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYEsigimapiILVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17438 49 AGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYG--------AFLFCRLISGFGIGGSLPIVFAYFSEFLAREK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFYSSFQYVTLVAGQMVALGVQivlqqlLSEPDMKAWG-----------WRIPFIIGAMGAVAVLWLRRTMDESEQF-- 213
Cdd:cd17438 121 RGEHLSWLCMFWMIGGLYASAMA------WSIIPHYGWGfsmgtnyhfhsWRVFVIICALPCIASIIALKFMPESPRFll 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 214 -----------------SNIKSQ-KRESAGTVRALMKHPKAVLTVVGLTL-----GGTVAFYTYTTYLQK---------- 260
Cdd:cd17438 195 emgkhdeawmilknihdTNMRAKgTPEKVFTVSNIKRKNTLFLAVVWFTMafsyyGLTVWFPDMIRYLQKhvtfedslfd 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 261 --------------------------------------FMVNTVGLPKE------------VVSWINFVALLIFVVLQPI 290
Cdd:cd17438 275 ecyfedvtstdtyfknctiestifyntdlyehkfidcrFINSTFLEQKEgchmdfeedndfLIYLVSFLGSLSVLPGNII 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 291 AGLLSDKIGRRPLlmafgILGTLLTAPI---FFFMEKTTEPIVAFLLMMVGliivTGYTSINA--IVKAELFPTEIRALG 365
Cdd:cd17438 355 SALLMDKIGRIKM-----IGGSMLISAVccfFLFFGNSESAMIGWQCLFCG----TSIAAWNAldVITVELYPTNKRATA 425
|
410 420
....*....|....*....|....*
gi 446002013 366 VGLPYALT--VAIFGGT--AEFIAL 386
Cdd:cd17438 426 FGILNGLCkfAAILGNSifASFVGI 450
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
190-413 |
1.39e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 44.03 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 190 FIIGAMGAVAVLWL----------------RRTMDESEQFSNIKSQKRESAGTVRALMKHPKAVLTVVGLTLgGTVAFYT 253
Cdd:cd17337 148 FTIPVIGEIGTLWLslvfvalgglialflvRDRTGEQPLANPSEEPLKELLSGITILFRNPKIAIGGIVRII-NTLSQFG 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 254 YTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEP--IVA 331
Cdd:cd17337 227 FPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWFGGVGCAISTLLFYYVPQLFGHnyWAA 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 332 FLLMMVGLIIVTGYTSINAIVKAeLFPTEIRA------LGVGLPYALTVAIfggtaefIALWLKSIGMESLFYFYVAGCI 405
Cdd:cd17337 307 LIAAILFGIGLAGFVPLSALMPS-LAPEHKGAamsilnLGAGLSNFVGPAI-------VTLFLGSFGAGGVVWIFAGLYL 378
|
....*...
gi 446002013 406 AISFITYW 413
Cdd:cd17337 379 LSAVLTLF 386
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
67-416 |
1.71e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSyesigimaPIILVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--------PWLFAIALVLTGFGGGLFEPASEAMIADVTTPEN 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFYSSFQYVTLVAGQMVALGVQIVLQQLlsepdmkawGWRIPFIIGAM-----GAVAVLWLRRTMDESEQfsniksQKR 221
Cdd:cd17329 122 RTRAFSLLYWAINLGVAIGPLLGGLLLLY---------SFRLLFLAAAVlfllaALVLLFLLPETRPKRRA------AEK 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 222 ESAGTVRALMKHPKAVLTVVGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRR 301
Cdd:cd17329 187 TEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 302 PLLMAFGILGTLLTAPIFFFMEKTTEpIVAFLLMMVGLIIVTgyTSINAIVkAELFPTEIRALGVGLpYALTVAIFGGTA 381
Cdd:cd17329 267 KILMIGILLFAIGFAVLAFANTLAVL-ILAMIVLTLGEMLVF--PAVQTLV-AALAPPDKRGSYMGF-YALAWGLGRAIG 341
|
330 340 350
....*....|....*....|....*....|....*
gi 446002013 382 EFIALWLKSIGMESLFYFYVAGCIAISFITYWRMD 416
Cdd:cd17329 342 PLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
37-368 |
2.19e-04 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 43.39 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 37 FSAEFFPK----------------GDPTSQLLNTAAIFAVgflmrPIGSLLMGRYADRHGRRAALTL-SITVMAGGSLii 99
Cdd:cd17361 25 FLEKFFPSvyekkkgasennyckyDDQLLQLFTSSLYLAG-----LVASLLASYVTRKWGRKPSMLIgGVLFLVGAAL-- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 100 actpsyesiGIMAPII--LVLARLLQGLSLGGEYGTSATYLSEMASSGRRG-FYSSFQYVTL---VAGQMVALGVQivlq 173
Cdd:cd17361 98 ---------NAAAQNIamLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGaLNIGFQLAITigiLIANLINYGTS---- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 174 qllsepDMKAWGWRIPfiIGAMGAVAVLWLRRT--MDESEQfsniksqkreSAGTVRALMkHPkAVLTVVGLTLggtVAF 251
Cdd:cd17361 165 ------KIKPNGWRLS--LGLAAVPALILLLGSlfLPETPN----------SPQLVIAIL-IP-FFQQLTGINV---IMF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 252 YTyttylqKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGT---LLTAPIFFFMEKTTEP 328
Cdd:cd17361 222 YA------PVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFLLLEGGVQMLasqVAIGILLAVKFGDGGE 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446002013 329 I---VAFLLMMVGLIIVTGY----TSINAIVKAELFPTEIRALGVGL 368
Cdd:cd17361 296 LpkaYAIAVVVLICLYVAAFawswGPLGWLVPSEIFPLETRSAGQSL 342
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
57-355 |
2.38e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.02 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 57 IFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESigimapiiLVLARLLQGLsLGGEYGTSAT 136
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQ--------LLILRLLQGV-FSGYVPNATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 137 YLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLLsepdmkawGWRIPFII-GAMGAVAVLWLrrTMDESEQFSN 215
Cdd:cd17391 112 LIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLF--------GIRNVFFItGGLLFLAFLLT--LFFVKEDFKP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 216 IKSQKRESAGTVRALMKHPKAVLTVVGLTLGGTVAFYTY----TTYLQKFMVNTVGLpkevvswiNFVALLIF------- 284
Cdd:cd17391 182 VEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIepilTLYIRQLMGDASNL--------AFISGLVFsatgvss 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446002013 285 VVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLL-MMVGLIIVTGYTSINAIVKAE 355
Cdd:cd17391 254 LLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLgLATGGLLPAINSLLAKITPKE 325
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
67-168 |
2.90e-04 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 42.86 E-value: 2.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYesigimapIILVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17435 51 LASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSY--------TVLIVGRIAIGVSISLSSIATCVYIAEIAPQHR 122
|
90 100
....*....|....*....|..
gi 446002013 147 RGFYSSFQYVTLVAGQMVALGV 168
Cdd:cd17435 123 RGLLVSLNELMIVIGILLAYIS 144
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
245-336 |
3.04e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 43.07 E-value: 3.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 245 LGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDK----IGR-RPLLMAFGILGTLLTAPIF 319
Cdd:pfam13347 7 LAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRtrtrWGRrRPWLLLSAIILAVSFILLF 86
|
90
....*....|....*..
gi 446002013 320 FFMEKTTEPIVAFLLMM 336
Cdd:pfam13347 87 TPPELGRAPLFIWLLAT 103
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
54-147 |
4.61e-04 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 41.95 E-value: 4.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 54 TAAIFAVGFLmrpIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYesigimapIILVLARLLQGLSLGGEYGT 133
Cdd:cd17379 38 FQSSLNLGFL---IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGGWMT 106
|
90
....*....|....
gi 446002013 134 SATYLSEMASSGRR 147
Cdd:cd17379 107 GYVLVTEFVGSKYR 120
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
67-371 |
5.21e-04 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 42.37 E-value: 5.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMaggsLIIACTPSYESIGIMAP--------IILVLARLLQGLSLGGEYGTSATYL 138
Cdd:PRK10077 70 IGGALGGYCSNRFGRRDSLKIAAVLF----FISALGSAWPEFGFTSIgpdntgyvPEFVIYRIIGGIGVGLASMLSPMYI 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 139 SEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLqqLLSEPDMkaW----GWRIPFIIGAMGAVAVLWLRRTMDESEQFS 214
Cdd:PRK10077 146 AEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFI--ARSGDAS--WlntdGWRYMFASEAIPALLFLMLLYFVPETPRYL 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 215 NIKSQKRESAGTVRALMKHPKA--------------------------VLTVVGLTL-------GGTVAFYtYTTYLQKF 261
Cdd:PRK10077 222 MSRGKQEQAEGILRKIMGNTLAtqalqeikhsldhgrktggkllmfgvGVIVIGVMLsvfqqfvGINVVLY-YAPEIFKT 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 262 M---VNTVGLPKEVVSWINfvalLIFVVlqpIAGLLSDKIGRRPLLMAFGI---LGTLLTAPIFFFMEKTTEPIVAFLLM 335
Cdd:PRK10077 301 LgasTDIALLQTIIVGVIN----LTFTV---LAIMTVDKFGRKPLQIIGALgmaIGMFSLGTAFYTQAPGIVALLSMLFY 373
|
330 340 350
....*....|....*....|....*....|....*.
gi 446002013 336 MVGLIIVTGytSINAIVKAELFPTEIRALGVGLPYA 371
Cdd:PRK10077 374 VAAFAMSWG--PVCWVLLSEIFPNAIRGKALAIAVA 407
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
183-314 |
5.90e-04 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 41.80 E-value: 5.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 183 AWGWRIPF-IIGAMGAVAVLWLRRTMdeseqfSNIKSQKRESAGTVRALMKHPkAVLTVVGLTLGGTVAFYTYTTYLQKF 261
Cdd:PRK03545 159 YLGWRTTFlAIGGGALITLLLLIKLL------PLLPSEHSGSLKSLPLLFRRP-ALVSLYLLTVVVVTAHFTAYSYIEPF 231
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446002013 262 MVNTVGLPKEVVSWInfvaLLIFVVLQPIAGLLSDKIGRRP----LLMAFGILGTLL 314
Cdd:PRK03545 232 VQQVAGLSENFATLL----LLLFGGAGIIGSVLFSRLGNRHpsgfLLIAIALLLVCL 284
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
67-240 |
9.84e-04 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 41.50 E-value: 9.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESigimapiiLVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:TIGR01299 217 VGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGF--------FLFCRLLSGFGIGGAIPIVFSYFAEFLAQEK 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFYSSFQYVTLVAGQM--VALGVQIVLQQLLSEPDMKAW---GWRIPFIIGAMGAVAVLWLRRTMDESEQFSnIKSQKR 221
Cdd:TIGR01299 289 RGEHLSWLCMFWMIGGIyaAAMAWAIIPHYGWSFQMGSAYqfhSWRVFVIVCAFPCVFAIGALTFMPESPRFF-LENGKH 367
|
170 180
....*....|....*....|....*..
gi 446002013 222 ESAGTVRALMK--------HPKAVLTV 240
Cdd:TIGR01299 368 DEAWMILKLIHdtnmrakgHPEKVFSV 394
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
190-410 |
1.07e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.99 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 190 FIIGAMGAVAVLWLRRTMDESEQFSNIKSQKRESAGtvralmkhPKAVLTVVGLTLGGTVAFYTYTTYLQKFMvnTVGLP 269
Cdd:cd17370 163 AIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKL--------PKAFWLYLLAVALFALGNFSFAFLILRAQ--ELGLS 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 270 KEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPlLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVTGYTSin 349
Cdd:cd17370 233 AALIPLLYALFNLVYALAAYPAGRLSDRIGRKK-LLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIER-- 309
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446002013 350 AIVkAELFPTEIRALGVGLPYALT-VAIFGGTAEFIALWlKSIGMESLFYFyVAGCIAISFI 410
Cdd:cd17370 310 AAV-ADLVPAELRGTAYGLFNTVVgIGWLLASLIAGYLW-DLISPSAAFLF-SAVLALIALL 368
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
147-352 |
1.36e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.67 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFYSSFQYVTLVAGQMVALGVQIVLQQLLSEPDMKAWGWRIPFIIGAMGAVAVLWL---RRTMDESEQFSNIKSQKRES 223
Cdd:cd17332 134 RTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICffgTRERVVPPEEEKSKLPLLKS 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 224 AGTVRalmkHPKAVLTVVGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLqPIAGLLSDKIGRRPL 303
Cdd:cd17332 214 LKALL----KNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLAL-LPWPPLKKRFGKKKA 288
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 446002013 304 LMAfGILGTLLTAPIFFFMekttEPIVAFLLMMVGLIIVTGYTSINAIV 352
Cdd:cd17332 289 FFI-GLLLAILGLLLLFFL----PPGNLVLILVLAVLAGIGYGGANLLP 332
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
69-334 |
1.84e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 69 SLLMGRYADRHG-RRAALTLSITVMAGGSLIIACTPSYESIGIMAPIILVLARLL--QGLSLGGEY-GTSATYLSEMASS 144
Cdd:cd17471 49 SQWLGRLSDRGGdRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAfpQLFALAREYaDRSSGRDATLFNS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 145 GRRGFYSsfqyVTLVAGQMVALGVQIVlqqllsepdmkaWGWRIPFIIGAMGAVAVLWLRRTMDESeqfSNIKSQKRESA 224
Cdd:cd17471 129 VLRAAFS----LAWVIGPPLAFLLLDV------------LGFTGLFLLAALLYLVVALLVLFLLPS---VKPPAQKATPA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 225 GTVRALMKHPKAVLTVVGLTLGGTVAFyTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLL 304
Cdd:cd17471 190 SSLVKAPVNRRLLLLFAAFTLLFAANS-MYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLL 268
|
250 260 270
....*....|....*....|....*....|
gi 446002013 305 MAFGILGTLLtapiFFFMEKTTEPIVAFLL 334
Cdd:cd17471 269 LAGFLAGVLF----YLGLALATSLWQLIAL 294
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
275-372 |
2.88e-03 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 39.90 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 275 WINFVALLIFVVLQP---IAGLLSDKIGRRPLLMAFGILGTLltaPIFFFMEKTTEPIVAFLLMMVGLIIVTGYTSINaI 351
Cdd:cd17440 338 WIYFVNFLGTLAVLPgniVSALLMDRIGRLTMLGGSMVLSGI---SCFFLWFGTSESMMIGMLCLYNGLTISAWNSLD-V 413
|
90 100
....*....|....*....|.
gi 446002013 352 VKAELFPTEIRALGVGLPYAL 372
Cdd:cd17440 414 VTVELYPTDRRATGFGFLNAL 434
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
272-410 |
3.07e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 272 VVSWINFVALLIfvvlQPIAGLLSDKIGRRPlLMAFGILGTLLTAPIFFFMekTTEPIVAFLLMMVGLIIVTGYTSINAI 351
Cdd:cd17489 36 VVGLFTLAALLA----RPFAGRLLDRFGRKR-LLLIGLLIFALATLLYLLA--TSVALLLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 446002013 352 VkAELFPTEIRALGVGLpYALTVAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAISFI 410
Cdd:cd17489 109 V-ADIIPPSRRGEGIGY-YGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
58-179 |
4.08e-03 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 38.99 E-value: 4.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 58 FAVGFLMrpiGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSyesigimaPIILVLARLLQGLSLGGEYGTSATY 137
Cdd:cd17445 45 FILGFAS---GYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAAS--------PSLFMAMRFLLGAALAGVYLTLYLT 113
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 446002013 138 LSEMASSGRRGFYSSFQYVTLVAGQMVALGVQI------VLQQLLSEP 179
Cdd:cd17445 114 RLELCDPPQRLLVAMAGGLTMVGGHFLLLGLALgcgswrVLQGTITAP 161
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
67-213 |
4.72e-03 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 39.24 E-value: 4.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESigimapiiLVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17439 49 VGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGT--------FLFCRLLSGVGIGGSIPIVFSYFSEFLAQEK 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446002013 147 RGFYSSFQYVTLVAGQM--VALGVQIVLQQLLSEPDMKAW---GWRIPFIIGAMGAVAVLWLRRTMDESEQF 213
Cdd:cd17439 121 RGEHLSWLCMFWMIGGIyaSAMAWAIIPHYGWSFQMGSAYqfhSWRVFVLVCAFPSVFAIGALTTMPESPRF 192
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
24-344 |
5.26e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.98 E-value: 5.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 24 WYDW--YVYSA------FAVYFSAEFFPKGDPTSQLLNTAAIfAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAgg 95
Cdd:COG2270 17 LYDWanSAFSTvittfvFPPYFTSVAALGDPAAATALWGYAL-AIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLG-- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 96 slIIACTpsyeSIGIMAPIILVLARLLQGL-SLGGEYGTS--ATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVL 172
Cdd:COG2270 94 --VLATA----ALFFVAPGGLWLGLLLFVLaNIGFEGSLVfyNAFLPDIATPEEIGRVSGLGWALGYLGGVLLLLINLAL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 173 QQLLSEPDMKAWGWRIPF---IIGAMGAVAVLWL------RRTMDESEQFSNIKSQKRESAGTVRALMKHPKAVLTVVGL 243
Cdd:COG2270 168 FLKPEAFGLPDAGEAVRIsflLTALWWLLFALPLflflpeRPRPGPAPPRGAVRAGFRELRRTLRELRRYRDLLRFLLAY 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 244 TL--GGTVAFYTYTTYlqkFMVNTVGLPKEVVswinfvaLLIFVVLQPIA-------GLLSDKIGRRPLLMAFGILGTLL 314
Cdd:COG2270 248 FFyrDGVQTVIAFAGI---YAAGVLGFSTTEL-------IVFGLLVQIVAalgallfGRLDDRIGPKRVILVSLVIWIVV 317
|
330 340 350
....*....|....*....|....*....|
gi 446002013 315 TAPIFFfmektTEPIVAFLLMMVGLIIVTG 344
Cdd:COG2270 318 CLAAYF-----LTTALAFWILGLLIGLVMG 342
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
245-349 |
5.47e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.74 E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 245 LGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKI-----GRRPLLMAFGILGTLLTAPIF 319
Cdd:cd17332 9 FGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTrsrwgRFRPWLLWGAIPLALLFVLLF 88
|
90 100 110
....*....|....*....|....*....|.
gi 446002013 320 F-FMEKTTEPIVAFLLMMVGLIIvtGYTSIN 349
Cdd:cd17332 89 TtPDGSGTGKLIYALITYILLDL--LYTLVN 117
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
55-367 |
5.54e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 38.67 E-value: 5.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 55 AAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYesigimapIILVLARLLQGLSLGGeYGTS 134
Cdd:cd17372 37 ALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNY--------MWLIILRCLVGLGLGG-GPQL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 135 ATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLLsepdmkAWGWRIPF--IIGAMGAVAVLWLRRTmdeseq 212
Cdd:cd17372 108 ASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRL------GWRWLLAFssVPSSLLLVFYRWTPKT------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 213 fsniksqkresagTVRALMKHPKAVLTVVGLTLGGTVAFYT----YTTYLQKFMVNTVGLPKEVVSWINFVALLIFVV-- 286
Cdd:cd17372 176 -------------TLLLWVIWFGNAFAYYGVVLLTTELNNShnvcGSKSDSDSGESPTEKQCRNSNDVDYRDVFIATFae 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 287 --LQPIAGLLSDKIGRRpLLMAFgilgTLLTAPIFFF-MEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTEIRA 363
Cdd:cd17372 243 fpGLLISAAMIDRLGRK-ASMAS----MLFTCCIFLLlLLICQSPFILTVLLFGGRACISAAFTVVYIYTPEVYPTAVRA 317
|
....
gi 446002013 364 LGVG 367
Cdd:cd17372 318 LGVG 321
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
54-313 |
5.72e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 5.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 54 TAAIFAVGFLMRPigslLMGRYADRHGRRaaltlsiTVMAGGsLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGT 133
Cdd:cd17489 37 VGLFTLAALLARP----FAGRLLDRFGRK-------RLLLIG-LLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 134 SATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQllsepdmkAWGWRIPFIIG---AMGAVAVLWLRRtmdes 210
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ--------HLGFAVLFIVAavlALLALLLVFLVK----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 211 EQFSNIKSQKRESAGTVRALMKhpKAVLTVVGLTLGGTVAFYTYTTYLQKFMVNTVGlpkeVVSWINF-VALLIFVVLQP 289
Cdd:cd17489 172 DPPPVAAEEAEAGTRAFRRLVE--KKVLPPALILFLASIAYGAISTFLPLYAAERGI----SNAGLFFtVYAIALLLSRP 245
|
250 260
....*....|....*....|....
gi 446002013 290 IAGLLSDKIGRRPLLMAFGILGTL 313
Cdd:cd17489 246 FSGKLSDRKGPKTVIIPGLLLLAL 269
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
51-209 |
7.24e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.31 E-value: 7.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 51 LLNTAAIFAVGFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTpsyesiGIMAPIILVLARLLQGLSLGGE 130
Cdd:COG2271 215 LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLA------LLPSPALAIALLFLAGFGLGGA 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 131 YGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVAlgvQIVLQQLLSepdmkAWGWRIPFIIGA----MGAVAVLWLRRT 206
Cdd:COG2271 289 FGLLWALAAELFPKKARGTASGLVNTFGFLGGALG---PLLVGYLLD-----ATGYQAAFLLLAalalLAALLALLLLRE 360
|
...
gi 446002013 207 MDE 209
Cdd:COG2271 361 TRK 363
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
272-409 |
8.67e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 38.75 E-value: 8.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 272 VVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFFMEkttepIVAFLLMMVGLIIVTGYTSINAI 351
Cdd:PRK08633 48 LTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYY-----LGWFWLAFAVTFLLGAQSAIYSP 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446002013 352 VKA----ELFPTEIRALGVGLPYALT-VAIFGGTAEF---IALWLKSIGMESLFYFYVAGCIAISF 409
Cdd:PRK08633 123 AKYgiipELVGKENLSRANGLLEAFTiVAILAGTALFsflFESVNGNTPSEILGRIAPAGLVLLAV 188
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
67-415 |
9.15e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 37.93 E-value: 9.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 67 IGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESigimapiiLVLARLLQGLSLGGEYGTSATYLSEMASSGR 146
Cdd:cd17502 45 AFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM--------LIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 147 RGFYSSFQyvtlvagqMVALGVQIVLQQLLSEPDMKAWGWRIPFIIG-AMGAVAVLWLRRTmdeseqfsniksqkresag 225
Cdd:cd17502 117 RGKYQGYI--------GAVFGIASVAGPLIGGAFTDHLSWRWCFYINlPIGGLALALLRTI------------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 226 tvralmkhpkAVLTVVGLTLGGtvAFYTYTTYLQKFMVNTVGLPKeVVSWINFVALLIFVVLQP-IAGLLSDKIGRRPLL 304
Cdd:cd17502 170 ----------LLSSIFGFLFGG--ALFGLIYYLPLYFQLVLGDSA-TKSGVRLLPLIIGLVIGSiISGALISKTGRYKPL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446002013 305 MAFG-ILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTEIralgvglPYALTVAIFG---GT 380
Cdd:cd17502 237 IVIGtILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADV-------GVATATNTFFrslGG 309
|
330 340 350
....*....|....*....|....*....|....*
gi 446002013 381 AEFIALWlksigmesLFYFYVAGCIAISFITYWRM 415
Cdd:cd17502 310 TLGVAIT--------DVFLVALALAALAFLLSLFL 336
|
|
| |
