|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
1-391 |
0e+00 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 632.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 1 MSRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFII 80
Cdd:PRK10473 1 MSRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 81 ASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
Cdd:PRK10473 81 ASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 161 WAMAMMGIAVLMLSLFILKETRPA-APAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGE 239
Cdd:PRK10473 161 YTMAAMGILVLLLSLFILKETRPArAPAASSKPRENSESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSRGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 240 YATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGP 319
Cdd:PRK10473 241 YAIIMALTAGVSMTVSFSTPFALGIFKPRTLMLTSQVLFLAAGITLALSPSHAVSLFGITLICAGFSVGFGVAMSQALGP 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446008127 320 FSLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLIMFVAPGRPVAAHEEIHHHA 391
Cdd:PRK10473 321 FSLRAGVASSTLGIAQVCGSSLWIWLAAVLGISAWNMLIGILIACSIVSLLLILFVAPGRPVAAHEEIPHHA 392
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
5-374 |
1.49e-88 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 272.53 E-value: 1.49e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 5 LICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVF 84
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 85 CSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMA 164
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 165 MMGIAVLMLSLFILKETRPAA---PAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYA 241
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEkrkPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 242 TIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVS-----PSHAVSLFGITLICAGFSVGFGVAMSQA 316
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAallggLSLWPLVAPLFLIFFGFGLIFPNATSLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446008127 317 LGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVV-GIGAWNMLIGILIACSIVSLLLIMF 374
Cdd:cd17320 321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLpNGTALPMGLLILVLGLLALLLLILL 379
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
11-375 |
1.41e-38 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 142.14 E-value: 1.41e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAET 90
Cdd:TIGR00710 13 LSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNN 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 91 STLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAV 170
Cdd:TIGR00710 93 IETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 171 LMLSLFILKETRP-AAPAASDKPRENSESLL-NRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTA 248
Cdd:TIGR00710 173 SALIFFILPETLPyEARIQISTYFETFLLLLkSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 249 GVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICA-----GFSVGFGVAMSQALGPFSLR 323
Cdd:TIGR00710 253 IAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMmfvgiGNSMISSIAMAYALEDFPHV 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446008127 324 AGVASSTLGIAQ-VCGSSLWIWLAAVVGIGAWNMLIGILiACSIVSLLLIMFV 375
Cdd:TIGR00710 333 AGTASALFGTLRlVLGAIVGYLVSLIHGNTAWPMSLSCL-VLAVVSVLAFYYL 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-341 |
9.72e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 133.95 E-value: 9.72e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 5 LICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVF 84
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 85 CSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMA 164
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 165 MMGIAVLMLSLFILKETRPAAPAAsdKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIM 244
Cdd:COG2814 172 VLALLALLLLLRLLPESRPAARAR--LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 245 ALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRA 324
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329
|
330
....*....|....*...
gi 446008127 325 -GVASSTLGIAQVCGSSL 341
Cdd:COG2814 330 rGRASGLYNSAFFLGGPL 347
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
14-374 |
2.99e-32 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 125.03 E-value: 2.99e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 14 LYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTL 93
Cdd:PRK11102 2 LMPLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 94 FLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLML 173
Cdd:PRK11102 82 LIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 174 SLFILKETRPAAPAASDKPR---ENSESLL-NRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAG 249
Cdd:PRK11102 162 VFFFIPETLPKERRQPFHLRttiRNFASLFrHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNIV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 250 VSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGF----SVGFGVAMSQALGPFSLRAG 325
Cdd:PRK11102 242 FLFVMTIINSRFVRRVGALNMLRFGLWIQFIMGIWLVVSALLDLGFWALVVGVAAFvgcvSMISSNAMAVILDEFPHMAG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446008127 326 VASSTLGIAQV-CGSSLWIWLAAVVGIGAWNMlIGILIACSIVSLLLIMF 374
Cdd:PRK11102 322 TASSLAGTLRFgIGAIVGALLSLAPFTSAWPM-VWSMAFCSILSILFYLY 370
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
21-362 |
4.73e-28 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 113.46 E-value: 4.73e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFL 100
Cdd:PRK11652 26 IYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 101 QGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKE 180
Cdd:PRK11652 106 QGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 181 TRPAAPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFErgeyatimaltagvSMTVS----- 255
Cdd:PRK11652 186 TRPADARRTRVLASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGLS--------------SMTVSilfil 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 256 ------FSTPFALGIFKPR-TLMITSQVLFLAAGITLAVSpshavSLFGIT-----LICAG---FSVG--FGVAMSQALG 318
Cdd:PRK11652 252 pipaafFGAWFAGRPNKRFsTLMWQSVICCLLAGLLMWIP-----GWFGVMnvwtlLVPAAlffFGAGmlFPLATSGAME 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446008127 319 PFSLRAGVASSTLGIAQVCGSSLWIWLAAVV------GIGAWNMLIGILI 362
Cdd:PRK11652 327 PFPYLAGTAGALLGGLQNIGSGLAALLSAMLpqtgqfSLGLLMTLMGLLI 376
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
23-349 |
1.80e-24 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 103.02 E-value: 1.80e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 23 LVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQG 102
Cdd:cd17321 16 NVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 103 LGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSlfilketr 182
Cdd:cd17321 96 IGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA-------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 183 paapaasdkprensesllnRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFAL 262
Cdd:cd17321 168 -------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 263 GIFKPRTLMITSQVLFLAAGITLA-VSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSL---RAGVASSTLGIAQVCG 338
Cdd:cd17321 229 DRFGPRLVLVAGLLLTAVGLLLLAlLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVpkeKAGAASGILNTARQLG 308
|
330
....*....|.
gi 446008127 339 SSLWIWLAAVV 349
Cdd:cd17321 309 GALGVALLGAL 319
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-372 |
4.75e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 102.27 E-value: 4.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGA 105
Cdd:cd17325 19 LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 106 GCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPAA 185
Cdd:cd17325 99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 186 PAASDKPRENSESLLNRFFLSRVVITTLSVSVILT----FVNTSPVLLMEIMGFERGEYATIMALtAGVSMTVSFSTPFA 261
Cdd:cd17325 179 NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFafgaLEPFLPLYAAELGGLSPAQIGLLFGA-QGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 262 LGIFKPRTLMITSqVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQAL----GPFSLRA---GVASSTLGIA 334
Cdd:cd17325 258 LSDRIGRKPLILI-GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALladiVPPEGRGtamGLFNTAFSLG 336
|
330 340 350
....*....|....*....|....*....|....*...
gi 446008127 335 QVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLI 372
Cdd:cd17325 337 MVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-343 |
1.03e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.57 E-value: 1.03e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 9 FALVLLYPAGIDMYLVGLPR-IAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSL 87
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 88 AETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMG 167
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 168 IAVLMLSLFILKETRPAAPAASDKPRENSESLLNRFFLSRV---VITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIM 244
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVlwlLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 245 ALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLA-VSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLR 323
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLlLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|
gi 446008127 324 AGVASSTLGIAQVCGSSLWI 343
Cdd:pfam07690 322 KEERGTASGLYNTAGSLGGA 341
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-377 |
9.10e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 98.40 E-value: 9.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 3 RFLICSFALVLLYPAGIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFII 80
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSvaAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 81 ASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 161 WAMAMMGIAVLMLSLFILketrpaapaasdkprensesllnrfflsrVVITTLSVSVILTFVNTSPVLLMEIMGFERGEY 240
Cdd:COG2271 168 LILGLPGLLLALLRFWLL-----------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 241 ATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPF 320
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446008127 321 SLRAGVASSTLGIAQVCGSSLWIWLAAVVGI----GAWNMLIGILIACSIVSLLLIMFVAP 377
Cdd:COG2271 299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYlldaTGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
9-375 |
1.99e-22 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 97.26 E-value: 1.99e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 9 FALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLA 88
Cdd:cd17474 5 FFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 89 ETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLkFPWQSLFWAMAMMGI 168
Cdd:cd17474 85 DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 169 AVLMLSLFILKETRPAAPAASDKPRENSESLLNRFFLSRVVITTLSVSVIL-TFVNTSPVLL---MEIMGFERGEYATIM 244
Cdd:cd17474 164 VAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYfAFLTYLPFLLellYGISPIIIGLLFAGW 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 245 ALTAGVsmTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLicagFSVGFGV------AMSQALG 318
Cdd:cd17474 244 SVLLAL--GSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVL----FGLGLGLnlplltTLVTELA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446008127 319 PFSLRaGVASSTLGIAQVCGSSLWIWLAAVV-GIGAWNMLIGILIACSIVSLLLIMFV 375
Cdd:cd17474 318 PEEER-GTASSLYNFVRFLGQAVGPLLFGLLlEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
3-387 |
1.00e-21 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 95.78 E-value: 1.00e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 3 RFLICSFALVLLYPA---GIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFI 79
Cdd:PRK15402 10 QALLFPLCLVLFEFAtyiANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 80 IASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSL 159
Cdd:PRK15402 90 LTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGM 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 160 FWAMAmmgiAVLMLSLFILKETRPAapAASDKPRENSESLLNRFFLS-----RVVITTLS---VSV-ILTFVNTSPVLLM 230
Cdd:PRK15402 170 FVLFA----ALAALSFFGLWRAMPE--TAGRVGEKLSLKELGRDYKLvlknrRFVAGALAlglVSLpLLAWIALSPVILI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 231 EIMGFERGEYA-----TIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGF 305
Cdd:PRK15402 244 SGEQLSSYEYGllqvpVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYAFGI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 306 SVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGIL-IACSIVSLLLIMFVAPGRPVAAH 384
Cdd:PRK15402 324 GLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFnLANGLLWLLLVRIFLKDKPMGNA 403
|
...
gi 446008127 385 EEI 387
Cdd:PRK15402 404 HEG 406
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-285 |
1.06e-21 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 94.11 E-value: 1.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 3 RFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIAS 82
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 83 VFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWA 162
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 163 MAMMGIAVLMLSLFiLKETRPAAPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYAT 242
Cdd:COG0477 174 NAPLGLLALVLRLR-LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 446008127 243 IMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITL 285
Cdd:COG0477 253 LLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
19-363 |
1.49e-21 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 95.34 E-value: 1.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 19 IDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGR 98
Cdd:PRK11043 22 TDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 99 FLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIaVLMLSLFIL 178
Cdd:PRK11043 102 FVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITL-LLILPTLRL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 179 KETRPAAPAASDKPReNSESLLNRFFLSRVVITTLSVSVILTFVNTSPVlLMEIMGFERGEYA------TIMALTAGvsm 252
Cdd:PRK11043 181 KPSKKARKQSQDALT-FKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPF-ILEQMGYSPADIGlsyvpqTIAFLVGG--- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 253 tvsFSTPFALGIFKPRTLMITSQVLF-LAAGITLAVSPSHAVSLFGITLICAGFSVGFG----VAMSQALGPFSLRAGVA 327
Cdd:PRK11043 256 ---YGCRAALQKWGGEQLLPWLLVLFaVSVIAIWLASLLSHPSLVPLLIPFCVMAAANGaiypIVVAQALRPFPQATGKA 332
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446008127 328 S---STLGIAQVCGSSL---WIWLAAVVGIGaWNMLIGILIA 363
Cdd:PRK11043 333 AalqNTLQLGLCFLASLlvsALISTPLLTTG-SVMLSTVVLV 373
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
1-241 |
1.54e-20 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 92.58 E-value: 1.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 1 MSRFLIcSFALVLLYPAGI-----------DMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKP 69
Cdd:PRK15403 4 MPRFFA-RHAATLFFPMALilydfaaylttDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 70 VAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHL 149
Cdd:PRK15403 83 VLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 150 IMLKFPWQSLFWAMAMMGIAVLMLSLFILKET--RPAAP-AASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSP 226
Cdd:PRK15403 163 LMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETvkRGAVPfSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSP 242
|
250
....*....|....*
gi 446008127 227 VLLMEIMGFERGEYA 241
Cdd:PRK15403 243 VILIDAGGMTTSQFA 257
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
3-375 |
2.05e-20 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 91.84 E-value: 2.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 3 RFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIAS 82
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 83 VFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDtLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLK---FPWQSL 159
Cdd:COG0738 88 LLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 160 FWAMAMMGIAVLMLSLFI-LKETRPAAPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERG 238
Cdd:COG0738 167 YLILAVLLLLLALLFLRSkLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 239 EYATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALG 318
Cdd:COG0738 247 TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALD 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446008127 319 PFSLRAGVASSTLGIAQVCGSSLWIWLAAVVG-IGAWNMLIGILIACSIVSLLLIMFV 375
Cdd:COG0738 327 GLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLAdAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
26-372 |
3.64e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 87.99 E-value: 3.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGA 105
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 106 GCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPAA 185
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 186 PAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIF 265
Cdd:cd17324 182 PGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 266 KPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWL 345
Cdd:cd17324 262 GRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAAL 341
|
330 340
....*....|....*....|....*...
gi 446008127 346 AAVV-GIGAWNMLIGILIACSIVSLLLI 372
Cdd:cd17324 342 GGLVlDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
24-309 |
1.58e-18 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 86.09 E-value: 1.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGL 103
Cdd:cd17503 17 VALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFIlketrp 183
Cdd:cd17503 97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 184 aapaasdkpreNSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALG 263
Cdd:cd17503 171 -----------DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLD 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 446008127 264 IFKPRTLMITSQVLFLAAGITLA-VSPSHAVSLFGITLICAGFSVGF 309
Cdd:cd17503 240 KFGPRLLLLAGLLLLALGTLLLAfLTPDTSLWLIILPLFIRGLGMGL 286
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-385 |
2.84e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 85.70 E-value: 2.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 3 RFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIAS 82
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 83 VFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWA 162
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 163 MAMMGIAVLMLSLFILKET-RPAAPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYA 241
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDPpAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 242 TIMALTAGVSMTVSFSTPFALGIFKPRTLMITSqVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFS 321
Cdd:COG2223 245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIV-FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDI 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446008127 322 LR---AGVASSTLGIAQVCGSSLWIWLAAVV--GIGAWNMLIGILIACSIVSLLLIMFVAPGRPVAAHE 385
Cdd:COG2223 324 FPtknAGAVYGLVGAAGGLGGFLGPLLFGALldATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
13-367 |
6.94e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 81.10 E-value: 6.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 13 LLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETST 92
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 93 LFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLM 172
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 173 LSLFILKETRPAAPAASDKPRENSESLLNRFFLSRVVITTLSV--SVILTFVntsPVLLMEIMGFERGEYATIMALtagv 250
Cdd:cd17489 166 LVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIayGAISTFL---PLYAAERGISNAGLFFTVYAI---- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 251 smTVSFSTPFALGIF--KPRTLMITSQVLFLAAGItLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSL---RAG 325
Cdd:cd17489 239 --ALLLSRPFSGKLSdrKGPKTVIIPGLLLLALGL-LLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVpphRRG 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446008127 326 VASSTLGIAQ----VCGSSLWIWLAAVVGIGAWNMLIGILIACSIV 367
Cdd:cd17489 316 AANGTFFIFFdlgiGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
9-371 |
3.33e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 79.39 E-value: 3.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 9 FALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLA 88
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 89 ETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLI--MLKFPWQSLFWAMAMM 166
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 167 GIAVLMLSLFILKETR--PAAPAASDKPRENSESLLNRFFLSRVVITTLSV----SVILTFVNTSPVLLMEIMGFERGEY 240
Cdd:cd06174 162 ALLAAILLLLVVPDPPesARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIflvnLAYYSFSTLLPLFLLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 241 ATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICaGFSVGFGVAMSQALGPF 320
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLL-GFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 446008127 321 SLRAGVASSTLGIAQVCGSSLWIWLAAVVGI-----GAWNMLIGILIACSIVSLLL 371
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFllaatFGLTGAFLVLAVLLLLAAIL 376
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
44-181 |
3.74e-16 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 74.61 E-value: 3.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 44 FSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDR 123
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 446008127 124 RRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKET 181
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
4-180 |
4.13e-16 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 79.16 E-value: 4.13e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 4 FLICSFaLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASV 83
Cdd:cd17323 1 VFIISF-LTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 84 FCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAM 163
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159
|
170
....*....|....*..
gi 446008127 164 AMMGIAVLMLSLFILKE 180
Cdd:cd17323 160 AIISGFCLILIFLFLPI 176
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
25-371 |
4.92e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 78.77 E-value: 4.92e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 25 GLPRIA-ADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGL 103
Cdd:cd17473 21 ALPAIAqHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLImLKFPWQSLFWAMAmMGIAVLMLSLFILKETRP 183
Cdd:cd17473 101 GVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVYL-LALPVLILVLLFLPEPAR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 184 AAPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALG 263
Cdd:cd17473 179 KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 264 IFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALG--PFSLRA---GVASSTLGIAQVCG 338
Cdd:cd17473 259 RLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSlvPPELRGramGIVTSAFFLGQFLS 338
|
330 340 350
....*....|....*....|....*....|....*
gi 446008127 339 SSLWIWLAAVVGIGAWNMLI--GILIACSIVSLLL 371
Cdd:cd17473 339 PLVLGPLVNLTGGLSGAFLIlgVLALVLAIVLLLL 373
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
17-375 |
7.10e-16 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 77.99 E-value: 7.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 17 AGIDMYLVG--LPRIAADLNASEaQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLF 94
Cdd:cd17502 8 AALDQTIVAtaLPTIVAEFGGLS-LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTML 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 95 LAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWA-MAMMGIAVLML 173
Cdd:cd17502 87 IVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYInLPIGGLALALL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 174 SLFILketrpaapaasdkprenseSLLNRFFLSRVVIttlsvsvilTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMT 253
Cdd:cd17502 167 RTILL-------------------SSIFGFLFGGALF---------GLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVI 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 254 VSFSTPFALG-IFKPRTLMITSQVLFLAAGITLAVSPSHA-VSLFGITLICAGFSVGFG-----VAMSQALGPFSLraGV 326
Cdd:cd17502 219 GSIISGALISkTGRYKPLIVIGTILMSVGAGLLTTLTLDTsKWLLIGYLILLGLGLGIGfqqplVAVQNAVPPADV--GV 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 446008127 327 ASSTLGIAQVCGSSLWIWLAAVVGIGawnmligilIACSIVSLLLIMFV 375
Cdd:cd17502 297 ATATNTFFRSLGGTLGVAITDVFLVA---------LALAALAFLLSLFL 336
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
3-180 |
5.93e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 72.77 E-value: 5.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 3 RFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIAS 82
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 83 VFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWA 162
Cdd:TIGR00895 97 LLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV 176
|
170
....*....|....*...
gi 446008127 163 MAMMGIAVLMLSLFILKE 180
Cdd:TIGR00895 177 GGIAPLLLLLLLMRFLPE 194
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
21-314 |
1.09e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 71.84 E-value: 1.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFL 100
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 101 QGLGAGcCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKe 180
Cdd:cd17504 94 QGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDL- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 181 trpaapaasdkprensesllnRFFLSRVVITTLSVSVILTFVNTSPVLLMEIM---------GFERGEYATIMALTAGVS 251
Cdd:cd17504 172 ---------------------RLLRRRNVLLANITALLAGFGMFMVFQLLPQLlqlptptgfGLGITEAGLLLLPGALVM 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446008127 252 MTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLIcagFSVGFGVAMS 314
Cdd:cd17504 231 LIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLL---IGIGLGLAFA 290
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
24-185 |
1.09e-13 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 72.41 E-value: 1.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGL 103
Cdd:TIGR00711 23 VAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRP 183
Cdd:TIGR00711 103 GGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKP 182
|
..
gi 446008127 184 AA 185
Cdd:TIGR00711 183 AA 184
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
59-309 |
3.83e-13 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 69.94 E-value: 3.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 59 GKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAgcCYVVAFAILRDTLDDRRRAKVLSLLNGITCI 138
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSVVMALLADLTREENRTKAMALIGASIGI 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 139 IPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPaAPAASDKPRENSESLLN--RFFLSRVVITTLSVS 216
Cdd:cd17472 131 AFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPK-IVQISEKEKKKLKKLLKnkRLLRLDFSIFILHFV 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 217 VILTFVnTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAvspSHAVSLF 296
Cdd:cd17472 210 LMAFFY-ILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLL---FAATSLW 285
|
250
....*....|...
gi 446008127 297 GITLICAGFSVGF 309
Cdd:cd17472 286 LLIIGLIIFFIGF 298
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
9-376 |
7.46e-13 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 69.14 E-value: 7.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 9 FALVLLYPAGIDM---YLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFC 85
Cdd:cd17330 2 FLVVFLDALGFGIvfpVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 86 SLAETSTLFLAGRFLQGLGAGcCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAM 165
Cdd:cd17330 82 GLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 166 MGIAVLMLSLFILKetrpaapaasdkprensesllnrfFLSRVVITTLSVSVILTFVNTS-PVLLMEIMGFERGEYATIM 244
Cdd:cd17330 161 LALLNLVLVLFFLP------------------------PLRRLLLVYFLIALAFAGLESVfSLFLKDRFGFSPSQIGLLL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 245 ALTAGVSMTVSFS-TPFALGIFKPRTLMITSQVLFLAAGITLAVSPShaVSLFGITLICAGFSVGFGVAMSQALGPFSLR 323
Cdd:cd17330 217 ALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASS--VPLLVLAAAILAFGTGIVFPALSALLSKSVP 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446008127 324 AGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLIMFVA 376
Cdd:cd17330 295 SKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
32-372 |
7.05e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.09 E-value: 7.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 32 DLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVV 111
Cdd:cd17316 30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 112 AFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFP----WQSLFWAMAMMGIAVLmlslfilketrpaapa 187
Cdd:cd17316 110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIGALPALLAL---------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 188 asdkprensesLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIFKP 267
Cdd:cd17316 174 -----------LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 268 RTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCG---SSLWIW 344
Cdd:cd17316 243 KKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGrlgGGGAPP 322
|
330 340
....*....|....*....|....*...
gi 446008127 345 LAAVVGIGAWNMLIGILIACSIVSLLLI 372
Cdd:cd17316 323 LIALLLASTGGTGVPALILALLAIVALI 350
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
26-376 |
8.09e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 66.05 E-value: 8.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGA 105
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 106 GCCYVVAFAILRDTLDDrRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPAA 185
Cdd:COG2807 121 AVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 186 PAASDKPRENseSLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIF 265
Cdd:COG2807 200 AAAPAAASLR--SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 266 K-PRTLMITSQVLFLAAGITLAVSPSHAvslfgITLICAGFSVGFGVAMSQALGPFSLRAG---VASSTLGIAQVCGSSL 341
Cdd:COG2807 278 GdRRPLLLLLGLLGLAGLLGLLLAPGSL-----PWLWAVLLGLGQGGLFPLALTLIGLRARtpaEAAALSGMAQSVGYLL 352
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446008127 342 WIWLAAVVGI-----GAWNMLIGILIACSIVSLLLIMFVA 376
Cdd:COG2807 353 AALGPLLVGAlhdatGSWTAALLLLAALAVLMLVAGLLAG 392
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-372 |
2.02e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 64.94 E-value: 2.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV-----AIPGAALFIIASVFCSLAETSTLFL 95
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 96 AGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSL 175
Cdd:cd06173 97 VLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 176 FILKETRPAAPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTS-----PVLLMEIMGFERGEYATIMALTAGV 250
Cdd:cd06173 177 FIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGAltvllPLLAKEVLGGGAAGYGLLLAAFGVG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 251 SMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMS--QALGPFSLRA---G 325
Cdd:cd06173 257 ALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTllQLRVPDELRGrvfS 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446008127 326 VASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLI 372
Cdd:cd06173 337 VYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
4-223 |
2.08e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 65.02 E-value: 2.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 4 FLICSFALVLlypAGIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIA 81
Cdd:cd17371 1 FWAAFLGWAL---DGFDLLLLGlvLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 82 SVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFP----WQ 157
Cdd:cd17371 78 TLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWR 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446008127 158 SLFWAMAMMGIAVLMLSLFiLKETRPAAPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVN 223
Cdd:cd17371 158 VLFLLGALPALLVLFIRRF-VKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGAL 222
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
18-173 |
2.62e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 64.14 E-value: 2.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 18 GIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFL 95
Cdd:cd17365 12 GFDLAVMGfvAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLA 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446008127 96 AGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLML 173
Cdd:cd17365 92 LLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
24-375 |
5.07e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 63.36 E-value: 5.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGL 103
Cdd:cd17319 24 VAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRP 183
Cdd:cd17319 104 AEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVWG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 184 aapaasdkprensesllnrfflsrVVITTLSVSVILTFVNT-SPVLLMEIMGF---ERGEYATIMALTAGVSMTVSFSTP 259
Cdd:cd17319 184 ------------------------LALGYFGINYALYGLLTwLPTYLKQARGFslkQVGLLAAIPFLAGAIGMILGGRLS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 260 FALGIFKPRTLMITSqvLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGS 339
Cdd:cd17319 240 DRLLRGARRLVIIIG--LLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGN 317
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 446008127 340 SLWIWLAAVVGI-----GAWNMLIGILIACSIVSLLLIMFV 375
Cdd:cd17319 318 LGGFVAPLLIGYlvdatGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
42-371 |
6.21e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 63.40 E-value: 6.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 42 IAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLD 121
Cdd:cd17329 39 LVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 122 DRRRAKVLSLLNGITCIIPVLAPVLGhLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPAAPAAsdkPRENSESLLN 201
Cdd:cd17329 119 PENRTRAFSLLYWAINLGVAIGPLLG-GLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA---EKTEILRGYK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 202 RFFLSRVVITTLSVSVILTFV-----NTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQV 276
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIyfqleSTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGIL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 277 LFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQA--LGPFSLRA---GVASSTLGIAQVCGSSLWIWLAAVVGI 351
Cdd:cd17329 275 LFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVaaLAPPDKRGsymGFYALAWGLGRAIGPLVGGLLLDLLGP 354
|
330 340
....*....|....*....|
gi 446008127 352 GawnMLIGILIACSIVSLLL 371
Cdd:cd17329 355 G---LPWLILAALGLIAAAL 371
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
42-181 |
9.04e-11 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 62.60 E-value: 9.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 42 IAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLD 121
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 122 DRRRAKVLSLLNGITCIIPVLAPVLGHLIMlkfPWQSLFWAMAMMGIAVLMLSLFILKET 181
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYMLLALLAYLIR---DWRWLQLAISLPGLLFLLLLWWLPRRT 165
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
33-178 |
1.70e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.82 E-value: 1.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 33 LNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVA 112
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446008127 113 FAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFIL 178
Cdd:cd17325 310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
9-194 |
2.84e-10 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 61.52 E-value: 2.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 9 FALVLLypAGIDMYLVGL--PRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCS 86
Cdd:PRK11551 21 FLVALL--EGLDLQSAGVaaPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 87 LAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLngiTCIIP---VLAPVLGHLIMLKFPWQSLFWAM 163
Cdd:PRK11551 99 QAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLM---YCGVPfggALASVIGVLAAGDAAWRHIFYVG 175
|
170 180 190
....*....|....*....|....*....|..
gi 446008127 164 AMMGIAVLMLSLFILKETR-PAAPAASDKPRE 194
Cdd:PRK11551 176 GVGPLLLVPLLMRWLPESRaFAQAAGAGKQRA 207
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
26-177 |
2.48e-09 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 58.35 E-value: 2.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGA 105
Cdd:cd17359 24 LPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 106 GCCYVVAFAILRDTLDDRRRAKVLSLLN-----GITCIIPV---LAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFI 177
Cdd:cd17359 104 GGASALVPMYIAEVAPAEIRGRLVSLNQlmivfGQLLAYIVnylIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFI 183
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
29-375 |
3.17e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 58.05 E-value: 3.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 29 IAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFL-QGLGAGC 107
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLlGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 108 CYVVAFAILRDTLDDRRRAKVLSLL-NGITCIIPVLAPVLGHLIMlKFPWQSLFWAMAMMGIAVLMLSLFIL---KETRP 183
Cdd:cd17355 109 LAAVAFATVAAWWFERRRGLALGILtAGGGLGSLVFLPLGAALIE-AFGWRTALLVLALLALLVLVPVLLLLrrrPADLA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 184 AAPAASDKPRENSESLL----NRFFLsRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTP 259
Cdd:cd17355 188 LRAYDDASPASPGSTLKealrSASFW-LLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 260 FALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGItLICAGFSVGFGVAMSQALGP---FSLRAGVASSTLGIAQV 336
Cdd:cd17355 267 WLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLF-AALFGLGWGATVPLTAALAAryfGARSYGTLFGLVFAPHQ 345
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 446008127 337 CGSSLWIWLAAVV--GIGAWNMLIGILIACSIVSLLLIMFV 375
Cdd:cd17355 346 LGSALGPWLGGLLydRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
26-367 |
3.90e-09 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 57.65 E-value: 3.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGA 105
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 106 GCCYvVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGH-LIMLKFPWQSLFWAMA-MMGIAVLMLSLFILKETRP 183
Cdd:cd17393 102 GALD-VAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAaAIGAGVSPGVHLLAAAvLLLLAALVAIRALLPGTGE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 184 AAPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALG 263
Cdd:cd17393 181 AAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 264 IFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMS----QALGPFSLRAGVASSTLGIAQVCGS 339
Cdd:cd17393 261 RFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSaagaLPGLAAGIAVARVATLGYLGFLVGP 340
|
330 340
....*....|....*....|....*...
gi 446008127 340 SLWIWLAAVVGIGAWNMLIGILIACSIV 367
Cdd:cd17393 341 PLIGFLADATGLRTAFLVVALLALLVAL 368
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
39-177 |
7.84e-09 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 56.71 E-value: 7.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 39 QLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRD 118
Cdd:cd17377 40 KVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNE 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 446008127 119 TLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMlkfPWQSLFWAMAMMGIAVLMLSLFI 177
Cdd:cd17377 120 CVGKSYWALAGSLGGLFFAVGIAQYALLGYFIR---SWRTLAVVVNLQGTLVFLLSLFI 175
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
13-314 |
9.36e-09 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 56.50 E-value: 9.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 13 LLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETST 92
Cdd:cd17476 8 LLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 93 LFLAGRFLQGLGAGCCYVVAFAILRDTLD-DRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVL 171
Cdd:cd17476 88 FFIICRALQGLGPAFLLPNAMALLGRTYPpGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 172 MLSLFIlketrpaapaasdkprenseslLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVS 251
Cdd:cd17476 168 VAAIFW----------------------TSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGG 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446008127 252 MTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHavSLFGITLICAGFSVGFGVAMS 314
Cdd:cd17476 226 VLAAITVGFLIARLPPSYIMAISMVAFLVGPILFATMPVH--QTYWAQAFPAMIVAPFGMDFS 286
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
24-372 |
2.74e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 55.02 E-value: 2.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGL 103
Cdd:cd17333 17 ILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 104 GAGCCYVVAFAILRdTLDDRRRAKVLSLLNGITCIIPVLAPVL-GHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKE-- 180
Cdd:cd17333 97 GAGILDTGANTFVG-ALFEESSATRLNVLHGFFGLGALIGPLIaTSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPel 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 181 --TRPAAPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFST 258
Cdd:cd17333 176 psARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 259 PFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCG 338
Cdd:cd17333 256 GPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIG 335
|
330 340 350
....*....|....*....|....*....|....*...
gi 446008127 339 SSL--WI--WLAAVVGIGAWnMLIGILIACSIVSLLLI 372
Cdd:cd17333 336 GAIipFImgFIAEAVGIQTA-MLLITILYAIIFVLALL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-182 |
3.68e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.88 E-value: 3.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 3 RFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGR--KPVAIPGAALFII 80
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 81 ASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170 180
....*....|....*....|..
gi 446008127 161 WAMAMMGIAVLMLSLFILKETR 182
Cdd:COG2271 341 LLLAALALLAALLALLLLRETR 362
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-177 |
1.45e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.00 E-value: 1.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 2 SRFLICSFALVLLYPAGIDMYLVGLPRIAAD-LNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFII 80
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 81 ASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*..
gi 446008127 161 WAMAMMGIAVLMLSLFI 177
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
31-112 |
1.91e-07 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 52.66 E-value: 1.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 31 ADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETST---LFLAGRFLQGLGAGC 107
Cdd:pfam00083 39 SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWsvyQLIVGRVLVGIGVGG 118
|
....*
gi 446008127 108 CYVVA 112
Cdd:pfam00083 119 ASVLA 123
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
1-192 |
1.95e-07 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 52.81 E-value: 1.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 1 MSRFLICSFALVLLY-PAGIDMYL--VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAAL 77
Cdd:PRK14995 1 MFRQWLTLVIIVLVYiPVAIDATVlhVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 78 FIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDT-LDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPW 156
Cdd:PRK14995 81 FGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATfTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYW 160
|
170 180 190
....*....|....*....|....*....|....*.
gi 446008127 157 QSLFWAMAMMGIAVLMLSLFILketrPAAPAASDKP 192
Cdd:PRK14995 161 GSVFLINVPIVLVVMGLTARYV----PRQAGRRDQP 192
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
26-200 |
5.13e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.47 E-value: 5.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGA 105
Cdd:cd17328 22 LPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGE 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 106 GCCYVVAFAILRDTLDDRRRAKVLSLLNgitCIIPV---LAPVLGHLI-MLKFPWQSLFWAMAMMGIAVLMLSLFILKET 181
Cdd:cd17328 102 ASYSPIAPTIIADLFPKEKRTRALGVFY---FAIPLgsgLGYVVGGLVaQATGGWRWAFRVTGVLGVLLAILLLLFVREP 178
|
170
....*....|....*....
gi 446008127 182 RPAAPAASDKPRENSESLL 200
Cdd:cd17328 179 PRGAAEGGVMAKSTATSFL 197
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
26-202 |
6.35e-07 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 51.07 E-value: 6.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGA 105
Cdd:PRK10213 43 LTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLAL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 106 GCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIavlmLSLFILKETRPAA 185
Cdd:PRK10213 123 GGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGV----LCIFWIIKSLPSL 198
|
170
....*....|....*..
gi 446008127 186 PAASDKPRENSESLLNR 202
Cdd:PRK10213 199 PGEPSHQKQNTFRLLQR 215
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
9-176 |
1.13e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 50.32 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 9 FALVLLYPAGIDMYL---VGLPRIAADLNASEAQLHIAfSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFC 85
Cdd:cd06179 1 AALCLAYFAQLFGVTlpaAVLPFIVADLGPSSNSTWIS-TAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 86 SLAETSTLFLAGRFLQGLGAGCCYVVAFAILrDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFP--WQSLFWAM 163
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTQGLGAAVAS-ELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYIN 158
|
170
....*....|...
gi 446008127 164 AMMGIAVLMLSLF 176
Cdd:cd06179 159 AIFNALALILLFF 171
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
71-349 |
1.76e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.90 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 71 AIPGAALFIIASVFCSLAETSTL--FLAGRFLQGLGAGCCYVVAFAILRD-TLDDRRRAKVLSLLNGITCIIPVLAPVLG 147
Cdd:COG2211 88 AIPLALSFVLLFTAPDLSPTGKLiyALVTYLLLGLAYTLVNIPYSALGAElTPDYEERTRLSSWRFAFAGLGGLLASVLP 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 148 HLIMLKFP------WQSLFWAMAMMGIAVLMLSLFILKEtRPAAPAASDKPRENSESLL-NRFFLSRVVITTLSVSVILT 220
Cdd:COG2211 168 PPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKE-RPVPEEEKVSLKESLKALLkNRPFLLLLLAYLLFFLALAL 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 221 FVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITL 300
Cdd:COG2211 247 VAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLA 326
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 446008127 301 ICAGFSVGFGVAMSQALGPFSL----------RAGVASSTLGIAQVCGSSLWIWLAAVV 349
Cdd:COG2211 327 ALAGIGLGAILVLPWAMLADVVdydewktgrrREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
26-375 |
4.46e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 48.38 E-value: 4.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLA-ETSTLFLAGRFLQGLG 104
Cdd:cd17353 26 NPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAiSLPLLFLGYGVLGGIG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 105 AGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPA 184
Cdd:cd17353 106 AGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 185 APAASDKPRENSESLLNRFFLSRVVIT----------TLSVSVILTFVNTSPVLLMEIMGFErgeyATIMALTAGVSMTV 254
Cdd:cd17353 186 VPPGVDPLANNAENSPRDYTPREMLRTptfwllwlmfFLNATAGLMLIGQAKPIGQEFAGLD----AGIAALAVSILSIF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 255 SFSTPFALGI----FKPRTLMITSQVLFLAAGITLAVSPSHAVsLFGITLICAGFSVGFGVAMSQALGP-------FSLR 323
Cdd:cd17353 262 NGGGRPFWGWlsdkIGRKNTLSIAFLIQGVAMFLLPFIGSVAV-LFVLGVALIGFCYGGGFALFPALTAdffgtknAGTN 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446008127 324 AGVASSTLGIAQVCGSSLwiwLAAVVGIGAWNMLIGILIACSIVSLLLIMFV 375
Cdd:cd17353 341 YGLLYTAKGVGGLIGPII---AAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
45-310 |
1.17e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 46.80 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 45 SVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRR 124
Cdd:cd17315 41 SSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 125 RAKVLSLLNGITCIIPVLAPVLGHLIMLKFP--WQSLFWAMAMMGIAVLMLsLFILKETRPaapaasdkprensesllnr 202
Cdd:cd17315 121 RGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPALLQLLL-MFFLPESRA------------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 203 FFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFErgeyaTIMALTAGVSMTVSFSTPFALGI---FKPRTLMITSQVLFL 279
Cdd:cd17315 181 LLVGVGLQLLQQLTGINAVMYYAPTIFKSAGGGT-----ASILASIIVGVVNLLATLVAIRLvdkVGRRPLLLIGFAGMA 255
|
250 260 270
....*....|....*....|....*....|....*....
gi 446008127 280 AAGITLAVS--------PSHAVSLFGITLICAGFSVGFG 310
Cdd:cd17315 256 ASLLLLAIAfllpalakAAGWLALLGILLYIAAFAMGAG 294
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
32-370 |
1.25e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 46.77 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 32 DLNASEAQLHIAFSVY-LAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETS-TLFLAGRFLQGLGAgCCY 109
Cdd:cd17471 26 ELGASPLQIGIFMTLSaLSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAFLRNYwVLLLVGVVLLSLGA-AAF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 110 VVAFAILRDTLD---DRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKEtRPAAP 186
Cdd:cd17471 105 PQLFALAREYADrssGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPS-VKPPA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 187 AASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIFK 266
Cdd:cd17471 184 QKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 267 PRTLMITSQVLFLA--AGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPfsLRAGVASS----TLGIAQVCGSS 340
Cdd:cd17471 264 KRRLLLAGFLAGVLfyLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMP--GQPGLATTlysnASRIGSLLGGL 341
|
330 340 350
....*....|....*....|....*....|
gi 446008127 341 LWIWLAAVVGIGAWNMLIGILIACSIVSLL 370
Cdd:cd17471 342 LAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
5-169 |
1.29e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 46.78 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 5 LICSFALVLLYPAGIDMYLVGLPrIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVF 84
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVP-MAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 85 CSLAETSTL--FLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWA 162
Cdd:cd17380 81 TPLLAYSSLplLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
....*..
gi 446008127 163 MAMMGIA 169
Cdd:cd17380 161 FGLLGLL 167
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
18-156 |
2.56e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 46.51 E-value: 2.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 18 GIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFL 95
Cdd:TIGR01299 180 GVEVFVVGfvLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFL 259
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446008127 96 AGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPW 156
Cdd:TIGR01299 260 FCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGW 320
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
45-310 |
3.51e-05 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 45.32 E-value: 3.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 45 SVYLAGMAAAmLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRR 124
Cdd:cd17361 59 SLYLAGLVAS-LLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 125 RAKVLSLLNGITCIIPVLAPVLGHLI--MLKFPWQSLFWAMAMMGIAVLMLSLFiLKETrPAAPaasdkprENSESLLNR 202
Cdd:cd17361 138 RGALNIGFQLAITIGILIANLINYGTskIKPNGWRLSLGLAAVPALILLLGSLF-LPET-PNSP-------QLVIAILIP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 203 FFLsrvvitTLS-VSVILTFVntsPVlLMEIMGFErGEYATIMALTAGVSMTVS-FSTPFALGIFKPRTLMITSQVLFLA 280
Cdd:cd17361 209 FFQ------QLTgINVIMFYA---PV-LFQTLGFG-SDASLISAVITGAVNVVStLVSIYLVDRFGRRFLLLEGGVQMLA 277
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 446008127 281 A----GITLAVS------PSHAVSLFGITLICAgFSVGFG 310
Cdd:cd17361 278 SqvaiGILLAVKfgdggeLPKAYAIAVVVLICL-YVAAFA 316
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-147 |
4.04e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 4.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 9 FALVLLYPAGIDMYLVGLPRIAAD-LNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSL 87
Cdd:COG2211 234 LLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF 313
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446008127 88 AETS--TLFLAGRFLQGLGAGCCYVVAFAILRDTLDD-------RRRAKVLSLLNGITCIIPVLAPVLG 147
Cdd:COG2211 314 LGPGnlWLLLVLAALAGIGLGAILVLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKLGQALAGALA 382
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
24-375 |
4.17e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 45.34 E-value: 4.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGL 103
Cdd:cd17312 24 VAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRP 183
Cdd:cd17312 104 FQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 184 A------APAASDKPRENSESLLNRFFLSRVVITTLSVSVILTfvntspvlLMEIMGFergeyatIMALTAGVSMTVSFS 257
Cdd:cd17312 184 YvwvlslAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSS--------LYEVGGI-------AGTILAGLLSDKLFG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 258 TPFALGIFKPRTLMITSQVLFLAAGITLAVSpshAVSLFGITLICAGFSVGFGVAMSQALGPfSLRAGVASSTLGIAQVC 337
Cdd:cd17312 249 GRRAPIAVIYMLLMTLSLALFWFFPHNKLLS---IVLLFLIGFFVGGPINLIGGAAAQDIGR-KEAAGTATGFVGLFGYL 324
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446008127 338 GSSLWIWLAAVV--GIGAWNMLIGILIACSIVSLLLIMFV 375
Cdd:cd17312 325 GASLAGLPLGYIidHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
14-156 |
5.26e-05 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 45.30 E-value: 5.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 14 LYPAGIDMYLVG--LPRIAADLNASEAQL-HIAFSVYLAGMAAAMLFAGkVADRSGRKPVAIPGAALFIIASVFCSLAET 90
Cdd:cd17438 8 LMADGVEVFVVGfvLPSAEKDMCLSSSNKgMLGLIVYLGMMAGAFIWGG-LADKLGRKRCLIISLAINASFAFLSSFVQG 86
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446008127 91 STLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPW 156
Cdd:cd17438 87 YGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGW 152
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
21-373 |
6.30e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.84 E-value: 6.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSG-RKPVAIPGAALFIIASVFCSLAETSTLFLAGRF 99
Cdd:cd17370 17 MARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 100 LQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIM--LKFPWQSLFWAMAMMGIAVLmLSLFI 177
Cdd:cd17370 97 LERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLylLGGNYRTIFLLAAIPALLAL-LILLF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 178 LKETRPAAPAASDKPRENSESLLNRFFLSRVVITTLsvsviLTFVNTSPVLLMeIMGFERGEYATIMALTAGVSMTVSFS 257
Cdd:cd17370 176 VVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVAL-----FALGNFSFAFLI-LRAQELGLSAALIPLLYALFNLVYAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 258 TPFALGIFKPR----TLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSV--GFGVAMSQALGPFSLRA---GVAS 328
Cdd:cd17370 250 AAYPAGRLSDRigrkKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAqeSIERAAVADLVPAELRGtayGLFN 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446008127 329 STLGIAQVCGSSLWIWLAAVVGIGAwnmLIGILIACSIVSLLLIM 373
Cdd:cd17370 330 TVVGIGWLLASLIAGYLWDLISPSA---AFLFSAVLALIALLLLL 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
9-316 |
7.28e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.47 E-value: 7.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 9 FALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLA 88
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 89 ETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGhLIMLKFPWQSLFWAMAMMGI 168
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLL-ALVGTAGALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 169 AVLMLSLfilkeTRPAAPAASDKPRenseslLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTA 248
Cdd:cd17477 161 ALVPLLL-----TRRAAPEIEEAES------ISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLL 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446008127 249 GVSMTVSFSTPFALGI----FKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVG-FGVAMSQA 316
Cdd:cd17477 230 AAFVLGGLLLQWPLGWladrFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPlYTLALALA 302
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
29-313 |
8.51e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 44.08 E-value: 8.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 29 IAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETST-LFLAGRFLQGLGAGC 107
Cdd:cd17352 29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWqLYLTYGVLGGLGLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 108 CYVVAFAILrDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQslfWAMAMMGIAVLMLSLFilketrpaapa 187
Cdd:cd17352 109 IYSPAIVIV-GQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWR---GALLILGGLCLNLCVC----------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 188 asdkprenseSLLNRFFLSR-VVITTLSVSVILTFVNTSPVLLMEIM---GFERGEYATIMALTAGVSMTVSFSTPFALG 263
Cdd:cd17352 174 ----------GLLLRLLKDPtFVLLALGVSFAMLGFFVPFVYLPSYAkslGIDESDAAFLLSIIGISDIVGRILLGLLAD 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 446008127 264 IFKPRTLMITSqVLFLAAGITLAVSP-SHAVSLFGITLICAGFSVGFGVAM 313
Cdd:cd17352 244 KPRIGRLYLYI-FTLLILGLSLLAFPlATTYVGLIVFSVLFGFCSGSYSSL 293
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
25-173 |
9.09e-05 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 44.66 E-value: 9.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 25 GLPRIAADLNASEAQlHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLG 104
Cdd:pfam06609 66 ALPNILQDIGQSENQ-GLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVA 144
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 105 AGCCYVVAFAIlRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMG-IAVLML 173
Cdd:pfam06609 145 AGPAGASPLFI-GELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSaIAVLLI 213
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
48-181 |
1.11e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 44.10 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 48 LAGMAAAmLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAK 127
Cdd:cd17358 52 LGALIGA-LLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGA 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446008127 128 vLSLLNGITCIIPVLapvLGHLIMLKFPWQSLFWAmammGIA---VLMLSLFILKET 181
Cdd:cd17358 131 -LGSLNQLLVNIGIL---LGYVLGSFLPWRTLALI----GAIppvVFLILLFFIPES 179
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
26-104 |
1.36e-04 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 43.95 E-value: 1.36e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446008127 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLG 104
Cdd:PRK10504 33 LPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVG 111
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
14-156 |
1.54e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 43.48 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 14 LYPAGIDMYLVG--LPRIAADLNASEA-QLHIAFSVYLAGMAAAMLFAGkVADRSGRKPVAIPGAALFIIASVFCSLAET 90
Cdd:cd17439 8 LMADGVEVFVVGfvLPSAEKDMCLSDSnKGMLGLIVYLGMMVGAFLWGG-LADRIGRRQCLLISLSVNSVFAFFSSFVQG 86
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446008127 91 STLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPW 156
Cdd:cd17439 87 YGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW 152
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
59-316 |
1.57e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.36 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 59 GKVADRSG-RKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAG--CCYVVAFAILRDTLDdrrRAKVLSLLNGI 135
Cdd:cd17490 52 GILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAAtwVSFTVLYASYFPPDE---AAKAMGLINLV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 136 TCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPAAPAAsdkpreNSESLLNRFFLSRVVITTLSV 215
Cdd:cd17490 129 NNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVL------TELKELLSVLKDKKLLFFSLL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 216 SVILTFVNTS------PVLLMEI--MGFERGEYATIMALTAGVSmtVSFSTPFALGIFKPRTLMITSqvlFLAAGITLAV 287
Cdd:cd17490 203 AILQQMITFSttfgftPLIAKQLgaSSFQLGLLSIIYLLPNALA--SLLSGTLFYKKLGERNTIIIG---FLLLGAYCFL 277
|
250 260 270
....*....|....*....|....*....|..
gi 446008127 288 SPSH-AVSLFGITLICAGFSVG--FGVAMSQA 316
Cdd:cd17490 278 IPFApNLTLLYLLQALNGFGTGilFPLLMSLS 309
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
5-304 |
2.02e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 43.01 E-value: 2.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 5 LICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAA-AMLFA---GKVADRSGRKPVAIPGAALFII 80
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYALmQFIFApilGALSDRFGRRPVLLLSLAGAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 81 ASVFCSLAETSTLFLAGRFLQGLgAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLiMLKFPWQSLF 160
Cdd:cd17388 81 DYLLMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGL-LGEISPRAPF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 161 WAMAMMGIAVLMLSLFILKETRPA-APAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGE 239
Cdd:cd17388 159 LVAAGLNGLNFLLGLFVLPESLPPeRRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFD 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446008127 240 YATIMA--LTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAG----ITLAVSPSHAVSLFGITLICAG 304
Cdd:cd17388 239 WSPTMVglSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADalgfLLLAFATQGWMVFPILILLALG 309
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
45-106 |
2.38e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 42.64 E-value: 2.38e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446008127 45 SVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAG 106
Cdd:cd17360 42 SSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVG 103
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
26-376 |
3.06e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 3.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGA 105
Cdd:cd17478 19 LPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 106 GCCYVVAFAILRDtLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPAA 185
Cdd:cd17478 99 AAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 186 PAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIF 265
Cdd:cd17478 178 KKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRF 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 266 KPRTLMITSqvlFLAAGITLAVSPSHAVSLFGITLICAGFSVG--FGVAMSQALGPFSLRAGVASS-TLGIAQVCGSSlw 342
Cdd:cd17478 258 GRRRVIIAS---LLLAAPFLLLFLLTPGIWSYILLVLAGFLLFasFPVTVVLAQELLPGNVGLASGlMMGLSFGLGGI-- 332
|
330 340 350
....*....|....*....|....*....|....*
gi 446008127 343 iwLAAVVGIGAWNMLIGI-LIACSIVSLLLIMFVA 376
Cdd:cd17478 333 --GAPVLGALADAFGLESvLLILALLPLLGALLAF 365
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
18-132 |
4.18e-04 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 42.09 E-value: 4.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 18 GIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFL 95
Cdd:cd17363 12 GVEVFVVGfvLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFL 91
|
90 100 110
....*....|....*....|....*....|....*..
gi 446008127 96 AGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLL 132
Cdd:cd17363 92 FCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWL 128
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
138-378 |
4.30e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.21 E-value: 4.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 138 IIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETR-----PAAPAASDKPRENSESLLNRFFLSRVVITT 212
Cdd:cd17332 151 LVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRervvpPEEEKSKLPLLKSLKALLKNRPFLILLLAY 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 213 LSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHA 292
Cdd:cd17332 231 LLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGN 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 293 VSLFGITLICAGFSVGFGVAMSQALGPFSL----------RAGVASSTLGIAQVCGSSLWIWLAA-VVGIGAWNMLIGIL 361
Cdd:cd17332 311 LVLILVLAVLAGIGYGGANLLPWAMLADVIdygelktgkrREGIFYSVMTFFRKLGLALAGALVGlILSLAGYVANAAAQ 390
|
250
....*....|....*..
gi 446008127 362 IACSIVSLLLIMFVAPG 378
Cdd:cd17332 391 SASALNGIRLLIAVLPA 407
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
35-177 |
6.96e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.54 E-value: 6.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 35 ASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV---AIPGAALFIIASVFcslAETSTLFLAGRFLQGLGAGCCYVV 111
Cdd:TIGR00898 124 EDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVlllSTLVTAVSGVLTAF---SPNYTVFLVFRLLVGMGIGGIWVQ 200
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446008127 112 AFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMlkfPWQSLFWAMAMMGIAVLMLSLFI 177
Cdd:TIGR00898 201 AVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIP---DWRWLQLAVSLPTFLFFLLSWFV 263
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
14-156 |
7.34e-04 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 41.44 E-value: 7.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 14 LYPAGIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETS 91
Cdd:cd17440 8 LMADGVEVFVVGfvLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGY 87
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446008127 92 TLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPW 156
Cdd:cd17440 88 GLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW 152
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
44-112 |
2.95e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 39.54 E-value: 2.95e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 44 FSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETS-TLFLAGRFLQGLGAGCCYVVA 112
Cdd:cd17356 51 VSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKwYQLIVGRIIAGLGVGFASVLV 120
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
42-339 |
9.70e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 37.63 E-value: 9.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 42 IAFSVYLAGMAAAMLFAGKVADRSGRKPVAIpgAALFIIASVFCSLAETSTLF--LAGRFLQGLGAGccYVVAFAILRDT 119
Cdd:cd17391 40 LAFSSTFLVSAIFSPIWGRLADRYGRKPMLL--RASLGMAIVIGLMAFVTNVWqlLILRLLQGVFSG--YVPNATALIAS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 120 LDDRRRA-KVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKET-RPAAPAASDKPRENSE 197
Cdd:cd17391 116 QTPKEKSgWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDfKPVEKKKMVSTKEVWN 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446008127 198 SLLNRFFLSRVVITTLsvsvILTFVNTS--PVL---LMEIMGFERGeYATIMALTAGVSMTVS-FSTPFA--LG--IFKP 267
Cdd:cd17391 196 SVPNPSLLISLFVTTF----IIQLANQSiePILtlyIRQLMGDASN-LAFISGLVFSATGVSSlLSAPRLgkLGdrIGHH 270
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446008127 268 RTLMITsqvLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGS 339
Cdd:cd17391 271 RILLGA---LLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQY 339
|
|
| |
