|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-409 |
7.34e-88 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 271.35 E-value: 7.34e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 38 TLALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLL 117
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 118 STMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIG 197
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 198 CFALASALMFWKILPESRHFRPTSLRPKSlfiNFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQAVV 277
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLGLLS---SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAII 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 278 GLLSLAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFGLLMTLFS-SLWLIFAGMLLFSAGFFAAHSVASSWIGPRAK 356
Cdd:cd17324 238 GLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGpSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446013974 357 RAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLVGT 409
Cdd:cd17324 318 EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
36-377 |
1.28e-42 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 152.82 E-value: 1.28e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 36 RVTLALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICT 115
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 116 LLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAA 195
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 196 IGCFALASALMFWKILPESRHFRPTSLRPkslfiNFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIGYRLMlSPWHVSQA 275
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRG-----SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ-EVLGLSAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 276 VVGLLSLAY-LTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFGL-LMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGP 353
Cdd:COG2814 244 AAGLLLALFgLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLlLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
330 340
....*....|....*....|....*
gi 446013974 354 RA-KRAKGQASSLYLFSYYLGSSIA 377
Cdd:COG2814 324 LApPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-407 |
8.88e-33 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 126.92 E-value: 8.88e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 41 LFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTM 120
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 121 MTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFA 200
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 201 LASALMFWKILPESRHFRPT-SLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIGYRLMlSPWHVSQAVVGL 279
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKrAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA-ELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 280 L-SLAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGVM-LFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRA-K 356
Cdd:cd17325 240 LfGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSaVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVpP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446013974 357 RAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLV 407
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVL 370
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
57-406 |
2.77e-28 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 114.60 E-value: 2.77e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 57 PILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGL 136
Cdd:cd17320 20 PALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 137 SLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKILPESRH 216
Cdd:cd17320 100 GAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 217 FRPTSLRPKSLFINFRLHWRDRGlplLFAEGFLLMGSFVTLFNYIGYR--LMLSPWHVSQAVVGLL----SLAYLTGTWS 290
Cdd:cd17320 180 EEKRKPLLSSLLRAYKRVLKNRR---FLGYALALGLSFAGLFAYLAAApfIYIEQLGLSPAQFGLLfalnAIALILGSLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 291 SPKAG---TMTTRYGRGPVMLFSTGVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRAKRAKGQASSLYL 367
Cdd:cd17320 257 NGRLVrrfGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLG 336
|
330 340 350
....*....|....*....|....*....|....*....
gi 446013974 368 FSYYLGSSIAGTLGGVFWHNYGWNgVGAFIALMLVIALL 406
Cdd:cd17320 337 FLQFLIGALAGALVGLLPNGTALP-MGLLILVLGLLALL 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
28-415 |
3.29e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 105.72 E-value: 3.29e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 28 KRGTPQFMRVTLALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTA 107
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 108 LLLASICTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFF 187
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 188 NWRIALAAIGCFALASA-LMFWkilpesrhfrptslrpkslfinfrlhwrdrglpLLFAEGFLLMGSFVTLFNYIGYRLM 266
Cdd:COG2271 162 GWRAAFLILGLPGLLLAlLRFW---------------------------------LLALAYFLVYFALYGFLTWLPTYLV 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 267 LSpWHVSQAVVGLL-SLAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFG---LLMTLFSSLWLIFAGMLLFSAGFFA 342
Cdd:COG2271 209 EV-RGLSLAQAGLLlSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAlalLLLALLPSPALAIALLFLAGFGLGG 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446013974 343 AHSVASSWIGPRA-KRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLVGTRLHRRL 415
Cdd:COG2271 288 AFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
35-417 |
7.30e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 104.96 E-value: 7.30e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 35 MRVTLALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASIC 114
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 115 TLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALA 194
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 195 AIGCFALASALMFWKILPESRHFRPTSlrPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIGyRLMLSPWHVSQ 274
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAA--AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP-PYLVDQFGLSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 275 AVVGLL-SLAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFGLLMTLFS--SLWLIFAGMLLFSAGFFAAHSVASSWI 351
Cdd:COG2223 241 ATAGLLaALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAlgSLWLFLVLFLLLGLALGGGNGAVFALV 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446013974 352 GPR-AKRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYG-----WNGVGAFIALMLVIALLVGTRLHRRLHA 417
Cdd:COG2223 321 PDIfPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsytaaFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
55-407 |
1.08e-22 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 98.41 E-value: 1.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 55 VQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALI 134
Cdd:cd17474 18 VDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 135 GLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDfFNWRIALAAIGCFALASALMFWKILPES 214
Cdd:cd17474 98 GIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 215 RhfRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIGYRLMLSPwHVSQAVVGLL-SLAYLTGTWSSPK 293
Cdd:cd17474 177 K--EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLY-GISPIIIGLLfAGWSVLLALGSLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 294 AGTMTT-RYGRGPVMLFSTGVMLFGLLMTLFS-SLWLIFAGMLLFSAGFFAAHSVASSWIGPRA-KRAKGQASSLYLFSY 370
Cdd:cd17474 254 VGRLLKkRFGARRILVIGLLLYALSLLLLGFVpSLALLLIAIVLFGLGLGLNLPLLTTLVTELApEEERGTASSLYNFVR 333
|
330 340 350
....*....|....*....|....*....|....*..
gi 446013974 371 YLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLV 407
Cdd:cd17474 334 FLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
39-414 |
3.71e-22 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 97.25 E-value: 3.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 39 LALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLS 118
Cdd:COG2807 21 LAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 119 TMMTSWHGILIMRALIGLSLsGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGC 198
Cdd:COG2807 101 SLAPSVALLLAGTALIGAGI-AVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWAL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 199 FALASALMFWKILPESRHFRPTSLRPKSLfinfRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQAvVG 278
Cdd:COG2807 180 LALLALLLWLPLLRRRPAAAAAAPAAASL----RSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATA-GL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 279 LLSLAYLTGTWSSPKAGTMTTRYG-RGPVMLFSTGVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRAKR 357
Cdd:COG2807 255 LLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRART 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 358 AK--GQASSLYLFSYYLGSSIAGTLGGVFW-HNYGWNGVGAFIALMLVIALLVGTRLHRR 414
Cdd:COG2807 335 PAeaAALSGMAQSVGYLLAALGPLLVGALHdATGSWTAALLLLAALAVLMLVAGLLAGRP 394
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
41-377 |
5.22e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 96.33 E-value: 5.22e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 41 LFSAGLATFALLYCVQPILP-VLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLST 119
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 120 MMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCF 199
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 200 ALASALMFWKIL--PESRHFRPTSLRPKSLFINFRLHWRDRGLPLLFAegFLLMGSFVTLFNYIGYRLMLSPWHVSQAVV 277
Cdd:pfam07690 161 SLLAAVLLLLPRppPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLA--LLLFGFAFFGLLTYLPLYQEVLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 278 GLLSLAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFG----LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGP 353
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAalglLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....*
gi 446013974 354 RA-KRAKGQASSLYLFSYYLGSSIA 377
Cdd:pfam07690 319 LApKEERGTASGLYNTAGSLGGALG 343
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
58-362 |
6.00e-21 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 93.96 E-value: 6.00e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 58 ILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLS 137
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 138 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKILPESRHF 217
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDF 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 218 ----RPTSLRPKSLFINFRLHW---------------------------RDRGLPLLFAEGFLLMGSFVTLFNYIGYRLM 266
Cdd:TIGR00895 199 lvskRPETVRRIVNAIAPQMQAeaqsalpeqkstqgtkrsvfkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLPKLMV 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 267 LSPWHVSQAVVGLLSLaYLTGTWSSPKAGTMTTRYGRGPVMLFS--TGVMLFGLLMTLFSSLWLIFAGML--LFSAGFFA 342
Cdd:TIGR00895 279 ELGFSLSLAATGGALF-NFGGVIGSIIFGWLADRLGPRVTALLLllGAVFAVLVGSTLFSPTLLLLLGAIagFFVNGGQS 357
|
330 340
....*....|....*....|
gi 446013974 343 AHSVASSWIGPRAKRAKGQA 362
Cdd:TIGR00895 358 GLYALMALFYPTAIRATGVG 377
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
41-407 |
8.60e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 93.26 E-value: 8.60e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 41 LFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTM 120
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 121 MTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDF--FNWRIALAAIGC 198
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 199 FALASALMFWKILPESRH---FRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQA 275
Cdd:cd06174 161 LALLAAILLLLVVPDPPEsarAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 276 VVGLLSLAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGV--MLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIG- 352
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLlmALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAe 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 446013974 353 PRAKRAKGQASSLYLFSYYLGSSIAGTLGGVFW-HNYGWNGVGAFIALMLVIALLV 407
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAIL 376
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
31-417 |
1.69e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.45 E-value: 1.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 31 TPQFMRVTLALFSAGLATFALLYCVQ-PILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALL 109
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWgPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 110 LASICTLLSTMMTSWHGILIMRALIGLSLsGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDF--- 186
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGL-GLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLgls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 187 FNWRIALAAIGCFALASALMFWKI-LPESrhfRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIGyRL 265
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSkLPEI---EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLP-LY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 266 MLSPWHVSQAVVGLL----SLAYLTGTWSspkAGTMTTRYGRGPVMLFSTGVMLFGLLMTLFSS-LWLIFAGMLLFSAGF 340
Cdd:COG0738 237 LKDVLGLSEATAALGlslfWGGMTIGRFL---GGFLLKRFGPVRLLRLSALLAAVGLLLALLAPgPWLALIGLALVGLGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446013974 341 FAAHSVASSWIGPRAKRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLVGTRLHRRLHA 417
Cdd:COG0738 314 SLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
41-384 |
2.39e-18 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 85.71 E-value: 2.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 41 LFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTM 120
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 121 MTSWHGILIMRALIGLSLsGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFA 200
Cdd:cd17504 81 APNLPVLIAGRALQGIGG-AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 201 LASALMfwkilpesrhfrptslrpkSLFINFRLhWRDRGLPLLFAEGFLLMGSFVTLFNYIGYRLMLSPWH---VSQAVV 277
Cdd:cd17504 160 VLLAAL-------------------VPLIDLRL-LRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTgfgLGITEA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 278 GLLSLAY-LTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFGLLMTLF--SSLWLIFAGMLLFSAGF-FAAHSVASSWIGP 353
Cdd:cd17504 220 GLLLLPGaLVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALlhSSLWALVVALLLIGIGLgLAFASLPNIVVES 299
|
330 340 350
....*....|....*....|....*....|.
gi 446013974 354 RAKRAKGQASSLYLFSYYLGSSIAGTLGGVF 384
Cdd:cd17504 300 VPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
41-412 |
2.00e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 83.03 E-value: 2.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 41 LFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTM 120
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 121 MTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFA 200
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 201 LASALMFWKIlpesrhfRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTlFNYIGYRLMLSPWHVSQAVVGLL 280
Cdd:cd17489 161 LLALLLVFLV-------KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIA-YGAISTFLPLYAAERGISNAGLF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 281 SLAY-LTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFGLLMTLFS-SLWLIFAGMLLFSAGFFAAHSVASSWIGPRAKRA 358
Cdd:cd17489 233 FTVYaIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAgSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446013974 359 K-GQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLVGTRLH 412
Cdd:cd17489 313 RrGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
35-318 |
7.73e-17 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 80.63 E-value: 7.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 35 MRVTLALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASIC 114
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 115 TLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALA 194
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 195 AIGCFALASALMFWKiLPESRHFRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQ 274
Cdd:COG0477 173 INAPLGLLALVLRLR-LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 446013974 275 AVVGLLSLAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFGL 318
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
58-384 |
2.09e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 79.91 E-value: 2.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 58 ILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLS 137
Cdd:cd17321 18 ALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 138 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMfwkilpeSRHF 217
Cdd:cd17321 98 AAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL-------ARTF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 218 RPTSLrpkslfinfrlhwrdrglpLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQAVVGLlslaYLTGTWSSPKAGTM 297
Cdd:cd17321 171 SGAVL-------------------AAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPL----ALAMLVAAPLAGRL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 298 TTRYGRGPVMLFSTGVMLFGLLMTLF----SSLWLIFAGMLLFSAGF-FAAHSVASSWIGPRAKRAKGQASSLYLFSYYL 372
Cdd:cd17321 228 ADRFGPRLVLVAGLLLTAVGLLLLALlgadSSVWLLLPGLVLLGLGLgLFATPLTNAALSSVPKEKAGAASGILNTARQL 307
|
330
....*....|..
gi 446013974 373 GSSIAGTLGGVF 384
Cdd:cd17321 308 GGALGVALLGAL 319
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
36-208 |
2.10e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 80.31 E-value: 2.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 36 RVTLALFSAGLATFALLYCVQPILPV-LSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASIC 114
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 115 TLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALA 194
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
170
....*....|....
gi 446013974 195 AIGCFALASALMFW 208
Cdd:cd17325 359 AAAALLLLAAVLFL 372
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
55-406 |
3.42e-16 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 79.52 E-value: 3.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 55 VQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALI 134
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 135 GLSLSGVAAVGMTYLSEeIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKILPES 214
Cdd:cd17478 95 GIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 215 RHFRPTSLRPKSLFINFRLHWRdrGLPLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQAVVgLLSLAYLTGTWSSPKA 294
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWR--ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGL-LLSLFLFAGAIGTLIG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 295 GTMTTRYGRGPVMLFSTGVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRAKRAKGQASSLYL-FSYYLG 373
Cdd:cd17478 251 GPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMgLSFGLG 330
|
330 340 350
....*....|....*....|....*....|...
gi 446013974 374 SSIAGTLGGVFWHnYGWNGVGAFIALMLVIALL 406
Cdd:cd17478 331 GIGAPVLGALADA-FGLESVLLILALLPLLGAL 362
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
37-407 |
6.95e-16 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 78.37 E-value: 6.95e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 37 VTLALFSAGLATFALLycvqPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTL 116
Cdd:cd17477 1 LLLSVALLGLGSGLLL----PLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 117 LSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLIsGVFTDFFNWRIALAAI 196
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALPFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 197 GCFALASALMFWKILPESRHFRPTSLRPKSLFinfrlhwrdRGLPLLFAEGF---LLMGSFVTLFNYIGYRLMLSpwhvS 273
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEAESISLRRLL---------RIAPLALLGAFvagFLEGAFYSLLPLYGLRLGLS----V 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 274 QAVVGLLSLAYLTGTWSSPKAGTMTTRYGRGPVMLFST--GVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWI 351
Cdd:cd17477 223 AQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCAllGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALA 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446013974 352 GPRAKRAK-GQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLV 407
Cdd:cd17477 303 GDRLPGDElVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
58-408 |
8.41e-16 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 78.41 E-value: 8.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 58 ILPVLSQeFGLTPANSSISLsISTAMLAIGL---LFTGP---LSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMR 131
Cdd:cd17472 15 VLPVLSV-YAKSLPGATPTL-IGLALGIYGLtqaIFQIPfglLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 132 ALIGlslSG-VAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKI 210
Cdd:cd17472 93 ALQG---SGaISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 211 LPESRHFRPTSLRPKSLFINFRLHWRDRGLPLL-FAEGFLLMGSFVTLFNYIGYRLMLSP--WHV--SQAVVGLLSLAYl 285
Cdd:cd17472 170 VPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSiFILHFVLMAFFYILPLLLTQLGGGKGqlWKVylPAILIGFILMVP- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 286 tgtwsspkAGTMTTRYGRG-PVMLFSTGVMLFGLLMTLFS--SLWLIFAGMLLFSAGFFAAHSVASSWIGPRA-KRAKGQ 361
Cdd:cd17472 249 --------FVIYAEKKGKMkQVFVSSILLIAVGFLLLLFAatSLWLLIIGLIIFFIGFNLLEALLPSLVSKIApKEYRGT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446013974 362 ASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLVG 408
Cdd:cd17472 321 AMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVS 367
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
58-208 |
5.38e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 75.70 E-value: 5.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 58 ILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLS 137
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446013974 138 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFW 208
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR 171
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
58-407 |
6.58e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 75.30 E-value: 6.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 58 ILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLS 137
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 138 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKILPESrhf 217
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQV--- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 218 rptslrpkslfinfrlhwrdrglpLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQAVVGLL-SLAYLTGTWSSPKAGT 296
Cdd:cd17319 182 ------------------------WGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLaAIPFLAGAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 297 MTTRYGRG----PVMLFSTGVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRAKRAK-GQASSLYLFSYY 371
Cdd:cd17319 238 LSDRLLRGarrlVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAaATAGGLINSGGN 317
|
330 340 350
....*....|....*....|....*....|....*..
gi 446013974 372 LGSSIAGTL-GGVFWHNYGWNGVGAFIALMLVIALLV 407
Cdd:cd17319 318 LGGFVAPLLiGYLVDATGSYTAAFLFLAAVALLAALL 354
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
57-342 |
9.69e-15 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 75.34 E-value: 9.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 57 PILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGL 136
Cdd:PRK11102 12 PALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 137 SLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKILPES-R 215
Cdd:PRK11102 92 AAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETlP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 216 HFRPTSLRPKSLFINFRLHWRD-RGLPLLFAEGFLLMGSFVTL----FNYIGYrlmlspWHVSQAVVG---LLSLAYLTg 287
Cdd:PRK11102 172 KERRQPFHLRTTIRNFASLFRHkRVLGYMLASGFSFAGMFSFLtagpFVYIEL------NGVSPQNFGyyfALNIVFLF- 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 446013974 288 twsspkagTMTTRYGRGPVMLFSTGVMLFGLLMTLFSSLWLIFAGmlLFSAGFFA 342
Cdd:PRK11102 245 --------VMTIINSRFVRRVGALNMLRFGLWIQFIMGIWLVVSA--LLDLGFWA 289
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
55-407 |
2.34e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 73.81 E-value: 2.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 55 VQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALI 134
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 135 GLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKILPES 214
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 215 RHFRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIG----YRLMLSPWHVSqavvGLLSLAYLTGTWS 290
Cdd:cd17475 175 PAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLlflhDHLGLSVVAAG----ALLAVAQLGGALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 291 SPKAGTMTTRYGRG---PVMLFSTGVMLFGLLMTLF----SSLWLIFAGMLLFSAGFFAAHSVASSWIGPRA-KRAKGQA 362
Cdd:cd17475 251 RIGLGRVSDRVFGGrrrPVLVITAAIAAAALLVLSLlspgTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAgPEQAGTA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446013974 363 SSLYLFSYYLGSSIAGTL-GGVFWHNYGWNGVGAFIALMLVIALLV 407
Cdd:cd17475 331 LGLANTINFIGIAIGPPLfGLLVDATHSYAPAWLALALLLVLAALL 376
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
57-407 |
9.40e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 72.22 E-value: 9.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 57 PILPVLSQEFGLTPAN-SSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIG 135
Cdd:cd17473 20 PALPAIAQHFVPNSELlVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 136 LSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDfFNWRIALAAIGcFALASALMFWKILPESR 215
Cdd:cd17473 100 IGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLILVLLFLPEPA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 216 HFRPTSLRPKSLfINFRLHWRdRGLPLLFAeGFLLMGSFVTLFNYIGYrLMLSPWHVSQAVVGL-LSLAYLTGTWSSPKA 294
Cdd:cd17473 178 RKSKSAASPGAA-TAAALPWK-RVLPIYFL-AFLAMLLFYVIPIQLPF-LLQERGGGSAALIGLaLAIASLAGAIGALLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 295 GTMTTRYGRGPVMLFSTGVMLFG-LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRA-KRAKGQASSLYLFSYYL 372
Cdd:cd17473 254 GRLKRRLGKRRLLAIGFALMALGfLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVpPELRGRAMGIVTSAFFL 333
|
330 340 350
....*....|....*....|....*....|....*
gi 446013974 373 GSSIAGTLGGVFWHNYGwNGVGAFIALMLVIALLV 407
Cdd:cd17473 334 GQFLSPLVLGPLVNLTG-GLSGAFLILGVLALVLA 367
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
57-404 |
2.08e-13 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 71.26 E-value: 2.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 57 PILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGL 136
Cdd:TIGR00710 26 PAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 137 SLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKILPESRH 216
Cdd:TIGR00710 106 GASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 217 FRPTSLRPKSlFINFRLHWRDRGLPL-LFAEGFLLMGSFVtlFNYIGYRLMLSPWHVSQAVVGLL----SLAYLTGTWSS 291
Cdd:TIGR00710 186 YEARIQISTY-FETFLLLLKSKMFWGyALIYGASFGGFFA--FFSGAPFVYIDIMGVSPSVFGLLfalnIIAMIFGGFLN 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 292 PKAGTMTTRYGRGPVMLFSTGVMLFGLLMTLFSSLW---LIFAGMLLFSAGFFAAHSVASSWIGPRAKRAKGQASSLYLF 368
Cdd:TIGR00710 263 GRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGswaMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASALFGT 342
|
330 340 350
....*....|....*....|....*....|....*.
gi 446013974 369 SYYLGSSIAGTLGGVFWHNYGWNgvgaFIALMLVIA 404
Cdd:TIGR00710 343 LRLVLGAIVGYLVSLIHGNTAWP----MSLSCLVLA 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
38-215 |
1.28e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 68.74 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 38 TLALFSAGLATFALLYCVQPILPV-LSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGR--KPVMVTALLLASIC 114
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 115 TLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALA 194
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170 180
....*....|....*....|.
gi 446013974 195 AIGCFALASALMFWKILPESR 215
Cdd:COG2271 342 LLAALALLAALLALLLLRETR 362
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
58-220 |
1.75e-12 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 68.96 E-value: 1.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 58 ILPVLSQEFGLTPANSSiSLsISTAMLA--IGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIG 135
Cdd:PRK03893 42 VLTEVQGEFGLTTVQAA-SL-ISAAFISrwFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 136 LSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRiALAAIGCFALASALMFWKILPESR 215
Cdd:PRK03893 120 MGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWR-ALFFIGILPIIFALWLRKNLPEAE 198
|
....*
gi 446013974 216 HFRPT 220
Cdd:PRK03893 199 DWKEK 203
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
36-407 |
9.31e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 66.14 E-value: 9.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 36 RVTLALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICT 115
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 116 LLSTMMTS-WHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALA 194
Cdd:cd17355 83 VLLALATSlWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 195 AIGCFALA----SALMFWKILPESRHFRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFL----LMGSFVTLFNYIGYRLM 266
Cdd:cd17355 163 VLALLALLvlvpVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLcgfaVVGLIVHLVPYLADRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 267 lsPWHVSQAVVGLLSLAYLTGTWSSpkaGTMTTRYGRGPVM---LFSTGVMLFGLLMTLFSSLWLIFAGMLLfsaGFFAA 343
Cdd:cd17355 243 --SPAAAAVALALIGLFNIVGRLLS---GWLGDRYSPRRLLaasYALRALGLALLLLLPFPPLALLLFAALF---GLGWG 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446013974 344 HSVASSWIGPRAKRAKGQASSLY---LFSYYLGSSIAGTLGGVFWHNYG-WNGVGAFIALMLVIALLV 407
Cdd:cd17355 315 ATVPLTAALAARYFGARSYGTLFglvFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALL 382
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
57-407 |
2.86e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 64.49 E-value: 2.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 57 PILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIG-RKPVMVTALLLASICTLLSTMMTSWHGILIMRALIG 135
Cdd:cd17370 20 SILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILER 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 136 LSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFN----WRIALAAIGCFALASALMFWKIL 211
Cdd:cd17370 100 LGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGgnyrTIFLLAAIPALLALLILLFVVKE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 212 PESRHFRPTSLRPKSLFINFRLHWRdrglpllfaegFLLMGSFVTLFNY----IGYRLMLSPWHVSQAVVgLLSLAYLTG 287
Cdd:cd17370 180 YPRPPKLRKKSKKTSLKKLPKAFWL-----------YLLAVALFALGNFsfafLILRAQELGLSAALIPL-LYALFNLVY 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 288 TWSSPKAGTMTTRYGRGPVMLFSTGVMLFG-LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRA-KRAKGQASSL 365
Cdd:cd17370 248 ALAAYPAGRLSDRIGRKKLLILGYLSLALAyLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVpAELRGTAYGL 327
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446013974 366 YLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLV 407
Cdd:cd17370 328 FNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
62-407 |
8.35e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 63.02 E-value: 8.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 62 LSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSLSGV 141
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 142 AAVGMTYLSEEIHPS--FVAFSMgLYISGNsIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKiLPESRHFRP 219
Cdd:cd17329 106 EPASEAMIADVTTPEnrTRAFSL-LYWAIN-LGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFL-LPETRPKRR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 220 TSlRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQAVVGLLSLAYLTGTWSSPKAGTMTT 299
Cdd:cd17329 183 AA-EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVE 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 300 RYGRGPVMLFSTGVMLFGLLMTLFS-SLWLIFAGMLLFSAGFFAAHSVASSWIGPRA-KRAKGQASSLYLFSYYLGSSIA 377
Cdd:cd17329 262 RFRLRKILMIGILLFAIGFAVLAFAnTLAVLILAMIVLTLGEMLVFPAVQTLVAALApPDKRGSYMGFYALAWGLGRAIG 341
|
330 340 350
....*....|....*....|....*....|
gi 446013974 378 GTLGGVFWHNYGWNGVGAFIALMLVIALLV 407
Cdd:cd17329 342 PLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
55-339 |
1.43e-10 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 62.65 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 55 VQPILPVLSQEFGLTPANSSISLsisTAMLAIGLLF---TGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMR 131
Cdd:PRK15402 32 IQPGMLAVVEDFNAGAEWVPTSM---TAYLAGGMFLqwlLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLR 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 132 ALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKIL 211
Cdd:PRK15402 109 FLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAM 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 212 PESRHFRPTSLRPKSLFINFRLHWRDRG-LPLLFAEGFL---LMG----SFVTL-----FNYIGYRLMLSPWHVSqAVVG 278
Cdd:PRK15402 189 PETAGRVGEKLSLKELGRDYKLVLKNRRfVAGALALGLVslpLLAwialSPVILisgeqLSSYEYGLLQVPVFGA-LIAG 267
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446013974 279 LLSLAYLTGTWSSPKagtmTTRYGRGPvMLFSTGVMLFGLLMTLFSSLWLIfAGMLLFSAG 339
Cdd:PRK15402 268 NLTLARLTSRRPLRS----LIRMGLWP-MVAGLLLAALATVISSHAYLWLT-AGLSLYAFG 322
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
58-407 |
3.17e-10 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 61.55 E-value: 3.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 58 ILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLS 137
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 138 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKI---LPES 214
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIrrfVKEP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 215 ------RHFRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIGYrlMLSPWHVSQ----AVVGLLSLAY 284
Cdd:cd17371 181 pqwqaaRAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSY--LTGERGLSFegsaGYLVVTILGG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 285 LTGTWSspkAGTMTTRYGRGP-VMLFSTGVMLFGLLMTLFSS-----LWLIFAGmLLFSAGFFAAHSVASSWIGPRAKRA 358
Cdd:cd17371 259 FLGYLA---GGFLADRIGRRNnFALFALGSAISILLYFFLPLsptliLILGFPL-GFFASGPFSGMGAYLTELFPTAVRA 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446013974 359 KGQAsslylFSYYLGSSIAG---TLGGVFWHNYGWNGVGAFIALMLVIALLV 407
Cdd:cd17371 335 TAQG-----FCYNVGRIIGAlfpFLVGFLATSGSLGTAIAVFAAVYYIAGLV 381
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
74-214 |
3.39e-10 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 58.04 E-value: 3.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 74 SISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEI 153
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446013974 154 HPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKILPES 214
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
60-221 |
5.03e-10 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 60.75 E-value: 5.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 60 PVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSLS 139
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 140 GVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIA--LAAIGCFALASALMFWkiLPESRHF 217
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIfyVGGVGPLLLVPLLMRW--LPESRAF 196
|
....
gi 446013974 218 RPTS 221
Cdd:PRK11551 197 AQAA 200
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
83-413 |
5.28e-10 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 60.77 E-value: 5.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 83 MLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGI--------LIMRALIGLSLSGVAAVGMTYLSEEIH 154
Cdd:cd17367 52 MRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIgiwapiilLLARLLQGLSVGGEYGTSATYLSEVAP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 155 PS----FVAFSMGLYISGNSIGGMSGRLISGVFTD----FFNWRIALAAIGCFALAsALMFWKILPESRHFRPTSLRPK- 225
Cdd:cd17367 132 PGrrgfYSSFQYVTLIGGQLLALGVLLVLQHTLGEdqmaAWGWRIPFLLGGVLAVV-VLWLRRGLEETESFEAIAESNEa 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 226 --SLFINFRLHWRdrglPLLFAEGFLLMGS-FVTLFNYIGYRLMLSPWHVSQAVV---GLLSLAYLTGTwsSPKAGTMTT 299
Cdd:cd17367 211 saGTLRELRRHPR----ELLLVVGLTAGGTlAFYTWTTYLQKFLVNTAGFSKGDAtwiTTAALLVFMLL--QPLGGRLSD 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 300 RYGRGPVMLFSTG---VMLFGLLMTL--FSSLWLIFAGM---LLFSAGFFAAHSVASSWIGPRAKRAKGQAsslylFSYY 371
Cdd:cd17367 285 RIGRRPLLLFFGIggtLATVPLLSALdhTDSPYTAFALVlvgLVFLSGYTSINAVVKAELFPTHVRALGVG-----LPYA 359
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446013974 372 LGSSIAG----TLGGVFWHNYGWNGVGAFIALMLVIALLVGTRLHR 413
Cdd:cd17367 360 LAVAIFGgtapYVALWLKSIGHEWVFFWYVAGLIAISLVVYLRMPE 405
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
23-238 |
1.06e-09 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 59.84 E-value: 1.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 23 PNQFIKRGTPQFMRVTLAL--FSAGLATFALLYCVQPILPVLSQEFGLTPAnsSISLSISTAMLAIGLLftGPLSDAIGR 100
Cdd:PRK15403 5 PRFFARHAATLFFPMALILydFAAYLTTDLIQPGIINVVRDFNADVSLAPA--SVSLYLAGGMALQWLL--GPLSDRIGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 101 KPVMVTALL---LASICTLLSTMMTSWhgiLIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGR 177
Cdd:PRK15403 81 RPVLITGALiftLACAATLFTTSMTQF---LIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGP 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446013974 178 LISGVFTDFFNWRIALAAIGCFALASALMFWKILPESRHFRPTSLRPKSLFINFRLHWRDR 238
Cdd:PRK15403 158 LSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNR 218
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
39-411 |
2.51e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 58.40 E-value: 2.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 39 LALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLS 118
Cdd:cd06173 2 RLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 119 TMMTSWHGILIMRALIGLSLSGVAA-----VGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIAL 193
Cdd:cd06173 82 ALLALLGSLSLWLLLVLAFLLGIASaffgpARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 194 AAIGCFALASA--LMFWKILPESRHFRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGsFVTLFNYIGYRLMLSPWH 271
Cdd:cd06173 162 AINALSFLLSAllLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFAL-LGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 272 VSQAVVGLLSLAYLTGTW-SSPKAGTMTTRYGRGPVMLFSTGVM-LFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASS 349
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALlGALLLGRLSKRRRRGRLLLIGALLLgLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446013974 350 WIGPRAKRAK-GQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLVGTRL 411
Cdd:cd06173 321 LLQLRVPDELrGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
59-406 |
6.37e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 57.28 E-value: 6.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 59 LPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSL 138
Cdd:cd17312 26 KPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 139 SGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWkilpesrhfr 218
Cdd:cd17312 106 SMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILF---------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 219 ptslrpkslfinFRLHWRDRGLpLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQAVVGLLSLAY----LTGTWSSPKA 294
Cdd:cd17312 176 ------------FFLRDSPPYV-WVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYevggIAGTILAGLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 295 GTMTTRYGRGPVMLFSTGVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSV------ASSWIGPraKRAKGQASSLYLF 368
Cdd:cd17312 243 SDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPInliggaAAQDIGR--KEAAGTATGFVGL 320
|
330 340 350
....*....|....*....|....*....|....*...
gi 446013974 369 SYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALL 406
Cdd:cd17312 321 FGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVL 358
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
38-342 |
7.33e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 56.84 E-value: 7.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 38 TLALFSAGLATFALLYCVQPILPVLSQEF--GLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICT 115
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 116 LLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFF----NWRI 191
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 192 ALAAIGCFALASALMFWKILpesrhfrptslrpkslfinfrlhwrdrglpLLFAEGFLLMGSFVTLFNYIGYrLMLSPWH 271
Cdd:cd17316 161 LFLIGALPALLALLLRRRTL------------------------------LLILLWFFISFGYYGLTTFLPT-YLQTVLG 209
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446013974 272 VSQAVVGLLSLAYLTGtwsspkagtmttrygrgpvmlFSTGVMLFGLLMTLFSSLWLIFAGMLLFSAGFFA 342
Cdd:cd17316 210 LSPATSSLYLLLISLG---------------------ALVGALIAGLLSDRIGRKKTLVIGLILSGILALP 259
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
36-417 |
2.26e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.68 E-value: 2.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 36 RVTLALFSAGLATFALLYcVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIG-----RKPVMVTALLL 110
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLL-SAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 111 ASICTLLSTMMTSWHGI------LIMRALIGLSLSGV-----AAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLI 179
Cdd:COG2211 91 LALSFVLLFTAPDLSPTgkliyaLVTYLLLGLAYTLVnipysALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 180 SGVF--TDFFNWRIALAAIGCFALASALMFWKILPESRHFRPTslrPKSLFINFRLHWRDRGLPLLFAeGFLLMGSFVTL 257
Cdd:COG2211 171 VAAFggDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE---KVSLKESLKALLKNRPFLLLLL-AYLLFFLALAL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 258 FNYIGYRLMLSPWHVSQAVVGLLSLAY-LTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFGLLMTLF---SSLWLIFAGM 333
Cdd:COG2211 247 VAALLLYYFKYVLGLSAALVGLLLALYfLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgpGNLWLLLVLA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 334 LLFSAGFFAAHSVASSWIGPRA--------KRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWN-------------- 391
Cdd:COG2211 327 ALAGIGLGAILVLPWAMLADVVdydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVagaaqspsaltgir 406
|
410 420
....*....|....*....|....*....
gi 446013974 392 ---GVGAFIALMLVIALLVGTRLHRRLHA 417
Cdd:COG2211 407 llfFLLPAVLLLLAALLLLFYPLTRERHA 435
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
32-173 |
4.16e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.59 E-value: 4.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 32 PQFMRVTLALFSAGLATFALLYCVQPIlpvLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLA 111
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLY---LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446013974 112 SICTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGG 173
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
57-211 |
6.96e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 54.12 E-value: 6.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 57 PILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGL 136
Cdd:cd17323 20 PALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGF 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446013974 137 SLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWR---IALAAIGCFALASALMFWKIL 211
Cdd:cd17323 100 FGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRwifWFLAIISGFCLILIFLFLPIV 177
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
59-391 |
1.04e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 53.35 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 59 LPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSL 138
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 139 SGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWR----IALA-AIGCFALASALMFwkilpe 213
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRwifyINLPiGILALLLAPLLDL------ 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 214 sRHFRptslrpkslFINFRLhwrdrGLPLLFAEGFLLMGSFVT----LFNYIGYRLMLSPWHV-SQAVVGLLslayltgt 288
Cdd:cd17503 173 -RLFK---------DRNFTL-----GLLLSFLLGLGLFGAMFLlplyLQNVLGYSAFESGLVLaPGGLASAI-------- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 289 wSSPKAGTMTTRYGRGPVMLFSTGVMLFGLLMTLF----SSLWLIFAGMLLFSAGFFAAHSVASSW-IGPRAKRAKGQAS 363
Cdd:cd17503 230 -LSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFltpdTSLWLIILPLFIRGLGMGLVFMPLNTLaLNSLPPEQIGDAT 308
|
330 340
....*....|....*....|....*...
gi 446013974 364 SLYLFSYYLGSSIAGTLGGVFWHNYGWN 391
Cdd:cd17503 309 ALFNTIRQLGGSIGTALLATLLTNRTQF 336
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
40-226 |
1.46e-07 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 53.39 E-value: 1.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 40 ALFSAGLA------TFALLYCvqpILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASI 113
Cdd:PRK12307 19 ALFSAWLGyvfdgfDFMLIFY---IMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 114 CTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIAL 193
Cdd:PRK12307 96 GTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAF 175
|
170 180 190
....*....|....*....|....*....|...
gi 446013974 194 aAIGCFALASALMFWKILPESRHFRPTSLRPKS 226
Cdd:PRK12307 176 -FVGLLPVLLVIYIRARAPESKEWEEAKLSGKG 207
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
40-208 |
1.77e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.94 E-value: 1.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 40 ALFSAGLATFallycvqpiLPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLsT 119
Cdd:cd17478 208 SWVLSSLTTF---------LPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLL-F 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 120 MMTSWHGILIMRALIGLSLSGVAAVGMTYlSEEIHPSFVAFSMGLYIS-GNSIGGMsGRLISGVFTDFFNWRIALAAIGC 198
Cdd:cd17478 278 LLTPGIWSYILLVLAGFLLFASFPVTVVL-AQELLPGNVGLASGLMMGlSFGLGGI-GAPVLGALADAFGLESVLLILAL 355
|
170
....*....|
gi 446013974 199 FALASALMFW 208
Cdd:cd17478 356 LPLLGALLAF 365
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
70-217 |
1.85e-07 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 53.04 E-value: 1.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 70 PANSSISLSISTAML--AIGLLFTGPLSDAIGRKPVMVTALLL---ASICTLLSTMMTSWHGILIMRALIGLSLSGVAAV 144
Cdd:pfam00083 43 ALSVLSGLIVSIFSVgcFIGSLFAGKLGDRFGRKKSLLIANVLfviGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVL 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446013974 145 GMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFN---WRIALAAIGCFALASALMFWKiLPESRHF 217
Cdd:pfam00083 123 APMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNsdgWRIPLGLQLVPALLLIIGLLF-LPESPRW 197
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
83-360 |
3.30e-07 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 51.99 E-value: 3.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 83 MLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGI--------LIMRALIGLSLSGVAAVGMTYLSEEIH 154
Cdd:cd17368 52 MRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATIgiaapllvLLARLLQGFAAGGEVGGVTAYLVEAAP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 155 P-------SFVAFSMGLyisGNSIGGMSGRLISGVFT----DFFNWRIALaAIGCFALASALMFWKILPESRHFRPTSLR 223
Cdd:cd17368 132 PgrrgfytSWQSASQQV---AIVAGALVGYLLSLTLTaealAEWGWRIPF-FIGLLIIPLGLWLRRSLEETEAFLERKAR 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 224 P--KSLFINFRLHWRdrglplLFAEGFLLMGSFVTLFNYIGYrlMLSPW-----HVSQAVVGLLSL-AYLTGTWSSPKAG 295
Cdd:cd17368 208 PtrRELFALLANNRR------IILLGMLLVAGSTVTFYFTTV--YTPTYaktvlGLSARDSFLVTLlAGVANFIWAPLGG 279
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446013974 296 TMTTRYGRGPVMLFSTgvmlFGLLMTLFSSLWLIFA----GMLL--------FSAGFFAAHSVASSWIGPRAKRAKG 360
Cdd:cd17368 280 ALSDRIGRRPVLLVIT----LAALVTLYPVFAWLTAapsfGRLLlvllvlsfFFGMYGGAMVVALVELFPVRVRSTG 352
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
271-417 |
3.81e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.80 E-value: 3.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 271 HVSQAVVGLL-SLAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFG-LLMTLFSSLWLIFAGMLLFSAGFFAAHSVAS 348
Cdd:COG2807 49 GLSATQAGLLtTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGlLLRSLAPSVALLLAGTALIGAGIAVGNVLLP 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446013974 349 SWIGPRAKRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLVGTRLHRRLHA 417
Cdd:COG2807 129 GLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPA 197
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
52-215 |
3.89e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 51.81 E-value: 3.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 52 LYCVQPILPVLSQEFGLTPANSSISLSISTAML--AIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILI 129
Cdd:cd17315 13 LGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLgaAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 130 MRALIGLSLSGVAAVGMTYLSEEIHPSFvafsMGLYISGNSIGGMSGRLISGVFTDFF-----NWRIALAAIGCFALASA 204
Cdd:cd17315 93 GRFLLGLGVGLASVLVPLYISEIAPAKI----RGALGTLNQLMITFGILLAYLLGLALslsppGWWRLMFALAAVPALLQ 168
|
170
....*....|.
gi 446013974 205 LMFWKILPESR 215
Cdd:cd17315 169 LLLMFFLPESR 179
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
39-406 |
5.08e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 51.39 E-value: 5.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 39 LALFSAGLATFALLycvqPILPV-LSQEFGLTPANSSISLSIStAMLAIGL-LFTGPLSDAIG-RKPVMVTALLLASICT 115
Cdd:cd17471 3 LATLLTGLAGAFVL----PYLSLfLTEELGASPLQIGIFMTLS-ALSGIVVsQWLGRLSDRGGdRKPLILLALLAGALGY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 116 LLSTMMTSWHGILImralIGLSLSGVAAVGMTYL-------SEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFN 188
Cdd:cd17471 78 LLFAFLRNYWVLLL----VGVVLLSLGAAAFPQLfalareyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 189 WRIALAAIGCFALASALMFWKILPESRHFRPTSLRPKSlfinfRLHWRDRGLPLLFAEGFLLMgsFVTLFNYIGYR--LM 266
Cdd:cd17471 154 FTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASS-----LVKAPVNRRLLLLFAAFTLL--FAANSMYIIAMplYV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 267 LSPWHVSQAVVGLL-SLAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGV-MLFGLLMTLFSSLWLIFAGMLLFSAGFFAAH 344
Cdd:cd17471 227 TNELGGSESWVGLLfGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAgVLFYLGLALATSLWQLIALQLLNAIFIGITA 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446013974 345 SVASSWIGPRAKRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALL 406
Cdd:cd17471 307 GLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
41-414 |
6.38e-07 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 51.25 E-value: 6.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 41 LFSAGLATFAL---LYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSdaiGRKPVMVTALLLASIC--- 114
Cdd:PRK10091 5 ILSLALGTFGLgmaEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFS---SRYSLKHILLFLVALCvig 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 115 TLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALA 194
Cdd:PRK10091 82 NAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 195 AIGCFALASALMFWKILPESRHFRPTSLRPKSLFINFRLHWrdrglpLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQ 274
Cdd:PRK10091 162 LIAVFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPW------LIFAATMFGNAGVFAWFSYIKPYMMFISGFSET 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 275 AVVGLLSLAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFGLLMTLFSS--LWLIFAGMLLFSAGFFAAHSVASSWIG 352
Cdd:PRK10091 236 SMTFIMMLVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLMLFFFGgmKTASLIFAFICCAGLFALSAPLQILLL 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446013974 353 PRAKRAKGQASSLYLFSYYLGSSIAGTLGGVFWH-NYGWNGV---GAFIALMLVIALLVGTRLHRR 414
Cdd:PRK10091 316 QNAKGGELLGAAGGQIAFNLGSAIGAYCGGMMLTlGLAYNYValpAALLSFAAMSSLLLYGRYKRQ 381
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
31-206 |
7.93e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 50.69 E-value: 7.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 31 TPQFMRVTLALFsagLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLL 110
Cdd:cd17353 212 TPTFWLLWLMFF---LNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLI 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 111 ASICTLLSTMMTSWHGI-LIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNW 189
Cdd:cd17353 289 QGVAMFLLPFIGSVAVLfVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGY 368
|
170
....*....|....*..
gi 446013974 190 RIALAAIGCFALASALM 206
Cdd:cd17353 369 NAAFIIAAALSLVALAL 385
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
35-210 |
1.57e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.92 E-value: 1.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 35 MRVTLALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASIC 114
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 115 TLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALA 194
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
170
....*....|....*.
gi 446013974 195 AIGCFALASALMFWKI 210
Cdd:cd06173 368 LAGALLLLAALLLLLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
248-411 |
1.65e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.59 E-value: 1.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 248 FLLMGSFVTLFNYIGYRLMLSP----WHVSQAVVGLLSLAY-LTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFGLLMTL 322
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALPLiaadLGASPAQAGLVVTAYlLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 323 FS-SLWLIFAGMLLFSAGFFAAHSVASSWIGPRAKRAK-GQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALM 400
Cdd:COG2814 94 LApSLWLLLAARFLQGLGAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
|
170
....*....|.
gi 446013974 401 LVIALLVGTRL 411
Cdd:COG2814 174 ALLALLLLLRL 184
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
57-251 |
2.12e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 49.52 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 57 PILPVLSQEFGLTPanSSISLSISTAMLAIGL--LFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALI 134
Cdd:PRK11652 29 PAIADMARDLNVRE--GAVQAVMAAYLLTYGLsqLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQ 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 135 GL--SLSGVAAVGMT---YLSEEIHPSFVAFSMGLYISgnsigGMSGRLISGVFTDFFNWR--IALAAIGCFALASALMF 207
Cdd:PRK11652 107 GLgtGVGGVMARTLPrdlYEGTQLRHANSLLNMGILVS-----PLLAPLIGGLLTTLFGWRacYLFLLLLGAGVTFSMAR 181
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 446013974 208 WkiLPESrhfRPTSLRPKSLFINFRLHWRDRGLpllfaEGFLLM 251
Cdd:PRK11652 182 W--MPET---RPADARRTRVLASYRTLLSNRRF-----NCYLLM 215
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
59-151 |
2.42e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 49.10 E-value: 2.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 59 LPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSL 138
Cdd:cd17359 24 LPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAV 103
|
90
....*....|...
gi 446013974 139 SGVAAVGMTYLSE 151
Cdd:cd17359 104 GGASALVPMYIAE 116
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
35-208 |
2.73e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.08 E-value: 2.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 35 MRVTLALFSAGLATFALLycvqpILpvLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASIC 114
Cdd:cd17370 205 YLLAVALFALGNFSFAFL-----IL--RAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 115 TLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALA 194
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFL 357
|
170
....*....|....
gi 446013974 195 AIGCFALASALMFW 208
Cdd:cd17370 358 FSAVLALIALLLLL 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-208 |
2.73e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 49.11 E-value: 2.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 32 PQFMRVTLALFSAGLATFALLYCVQPILpvlSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSD---AIGRKPVMVTAL 108
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYL---KQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 109 LLASICTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFF- 187
Cdd:cd17319 256 LLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATg 335
|
170 180
....*....|....*....|.
gi 446013974 188 NWRIALAAIGCFALASALMFW 208
Cdd:cd17319 336 SYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
73-208 |
3.23e-06 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 48.83 E-value: 3.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 73 SSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEE 152
Cdd:cd17374 37 KSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEW 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446013974 153 IHPSFVAFSMGLYISGNSIGGMsgrLISGVFTDFFNWRIALAAIGCFALASALMFW 208
Cdd:cd17374 117 TTPRHRALAITLTSCFFSIGQM---LLAGLAYAIRDWRLLQLVVSVPFFLFFLYSW 169
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
62-210 |
4.29e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 48.35 E-value: 4.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 62 LSQEFGLTPANS---SISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSL 138
Cdd:cd17317 13 IVTEWDLVCDRDwlvALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTS 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446013974 139 SGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMsgrLISGVFTDFFNWRIALAAIGCFALASALMFWKI 210
Cdd:cd17317 93 AGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYM---LLALLAYLIRDWRWLQLAISLPGLLFLLLLWWL 161
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
42-407 |
6.58e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 47.70 E-value: 6.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 42 FSAGLATFAllycVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMM 121
Cdd:cd17333 6 FSNGLTDAL----LGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 122 TSWHGILIMRALIGLSLSGVAAVGMTY---LSEEIHPSFVAFSMGLYisgnSIGGMSGRLISGVF-TDFFNWRIALAAIG 197
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAGILDTGANTFvgaLFEESSATRLNVLHGFF----GLGALIGPLIATSLlTSELSWSWAYLIIG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 198 --CFALASALMFWKILPESRHFRPTSLRPKSLFINFRLHWRdRGLPLLFAEGFLLMGSFVTLFNYIgYRLMLSPWHVSQA 275
Cdd:cd17333 158 liYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRN-PSIILGALALFLYVGAETAFSSWV-PSYLVEKKHVSDG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 276 VVGLLSLAYLTGTWSSPKAGTMTTRYGRGPVMLF--STGVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGP 353
Cdd:cd17333 236 LAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVlsGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGIS 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446013974 354 RAKRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYgwnGVGAFIALMLVIALLV 407
Cdd:cd17333 316 NLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAV---GIQTAMLLITILYAII 366
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
34-413 |
7.77e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 47.63 E-value: 7.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 34 FMRVTLALFSAGLATfallycVQPILPVLSQEFGLTPANSS----ISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALL 109
Cdd:cd17388 3 FILVTVLLDAMGIGL------IMPVLPTLLREFVGDSADAAthygVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 110 LASICTLLSTMMTSWHGILIMRALIGLSlSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNW 189
Cdd:cd17388 77 GAALDYLLMAFAPTLWWLYLGRIIAGIT-GATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 190 RIALAAIGCFALAsALMFWKILPESRH------FRPTSLRPkslFINFRLHWRDRGLPLLFAEGFLLMGS----FVTLFN 259
Cdd:cd17388 156 APFLVAAGLNGLN-FLLGLFVLPESLPperrraFRWRRANP---FGSLRWLTGFPGLLGLLAVFFLIQLIgqvpATTWVL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 260 YIGYRLMLSPWHV--SQAVVGLLSL---AYLTGtWSSPKAGTmttrygRGPVMLFSTGVMLFGLLMTLFSSLWLIFAGML 334
Cdd:cd17388 232 FTEDRFDWSPTMVglSLAVFGLLHAlfqAFVTG-PIAKRLGE------KRAILLGLAADALGFLLLAFATQGWMVFPILI 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 335 LFSAGFFAA---HSVASSWIGPRAK-RAKGQASSLylfsyylgSSIAGTLGGV------FWHNYGWNGVGAFIALMLVIA 404
Cdd:cd17388 305 LLALGGIAGpalQGLLSRQVPENEQgELQGVLTSL--------TSLTSIIGPLlftgifAASPATWPGLAWIIGAALYLI 376
|
....*....
gi 446013974 405 LLVGTRLHR 413
Cdd:cd17388 377 CLVLAYRFF 385
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
254-417 |
1.00e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.20 E-value: 1.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 254 FVTLFNYIGYRLMLS-------PWHVSQAVVGLL-SLAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFGLLMTLFS- 324
Cdd:cd17489 3 LANFFFFLSFYLLLPvlplyahDLGGSEAVAGLVvGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAt 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 325 SLWLIFAGMLLFSAGFFAAHSVASSW---IGPRAKRakGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALML 401
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLvadIIPPSRR--GEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170
....*....|....*.
gi 446013974 402 VIALLVGTRLHRRLHA 417
Cdd:cd17489 161 LLALLLVFLVKDPPPV 176
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-176 |
1.11e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 11 PASDTDKQSISQPNQFIKRGTPQFMRVTLALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLF 90
Cdd:pfam07690 175 PESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLL 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 91 TGPLSDAIGRKPVMVTALLLASICTL---LSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYIS 167
Cdd:pfam07690 255 LGRLSDRLGRRRRLLLALLLLILAALgllLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNT 334
|
....*....
gi 446013974 168 GNSIGGMSG 176
Cdd:pfam07690 335 AGSLGGALG 343
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
36-210 |
1.14e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 36 RVTLALFSAGLATFALLYCVQPILP-VLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDA-IGRKPVMVTALLLASI 113
Cdd:cd17474 198 RGLLTFLVSAFLYFFLYFAFLTYLPfLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 114 CTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIAL 193
Cdd:cd17474 278 SLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPF 357
|
170
....*....|....*..
gi 446013974 194 AAIGCFALASALMFWKI 210
Cdd:cd17474 358 LVGAAIALAAAVLLALL 374
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
189-409 |
1.76e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 47.23 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 189 WRIALAAIGCfALASALMFWKI--LPES---RHFRPTSLRPKSLFINFRLHWRDRGLpLLFAEG---FLLMGSFVTLfNY 260
Cdd:PRK08633 179 APAGLVLLAV-AVLGLIFAYRLpkVPAAapeVFDKKKYLFPKLLWRNLKLLRSDRVL-WLAIIGlsyFWFISQLAQA-NF 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 261 IGY---RLMLSPWHVSQAVVGLLSLAYLTGtwsSPKAGTMTTRYGR-GPVMLFSTGVMLFGLLMTLFSSLWLIFAGMLLF 336
Cdd:PRK08633 256 PAYakeVLGLDNTFQVQYLLAASAIGIGIG---SLLAGRLSGRHIElGLVPLGALGLALSLFLLPTAPSLASVLVLFFLF 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 337 --SAGFFaahSVA-SSWIGPRAKRA-KGQ---ASSLYLFSYYLGSSIAGTLggvfWHNYGWNGVGAFIALMLVIalLVGT 409
Cdd:PRK08633 333 gfSAGLF---IVPlNALIQFRAPEKeLGKvlaANNFLQNVGMLLFLALTTL----FSGLGLSPAGLFYLIALVT--LIGT 403
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
247-407 |
2.05e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 46.26 E-value: 2.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 247 GFLLMGSFVTLFNYIGYRLMLSPWHVSQAVVGLLSLAY-LTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFGLLMTLF-S 324
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFsLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFaS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 325 SLWLIFAGMLLFSAGFFAAHSVASSWIGPRAKRAK-GQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVI 403
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163
|
....
gi 446013974 404 ALLV 407
Cdd:pfam07690 164 AAVL 167
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
37-206 |
2.12e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 46.39 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 37 VTLALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTL 116
Cdd:cd17352 4 VVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 117 LSTMMTS-WHGILIMRALIGLSLsgvaavGMTYLseeihPSFVAFS----------MGLYISGNSIGGMSGRLISGVFTD 185
Cdd:cd17352 84 LSSFATSlWQLYLTYGVLGGLGL------GLIYS-----PAIVIVGqyfekkrglaTGIAVAGSGVGTFVFPPLLRYLLD 152
|
170 180
....*....|....*....|.
gi 446013974 186 FFNWRIALAAIGCFALASALM 206
Cdd:cd17352 153 NYGWRGALLILGGLCLNLCVC 173
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
41-215 |
2.23e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 46.46 E-value: 2.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 41 LFSAGLATFALLYCVQPILPVLSQEFGLTPansSISLSISTAmLAIGLLFTGP----LSDAIGRKPVMVTALLLASICTL 116
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDD---SLAGLLQTV-FIISYMVLSPifgyLGDRYNRKWILAVGILIWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 117 LSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFF-NWRIALAA 195
Cdd:cd17328 80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRV 159
|
170 180
....*....|....*....|
gi 446013974 196 IGCFALASALMFWKILPESR 215
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPP 179
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
39-207 |
2.47e-05 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 46.46 E-value: 2.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 39 LALFSAGLATFAllycVQPILPVLSQEFGLTPA---NSSISlSISTAMLAigLLFTGPLSDAIGRKPVMVTALLLASICT 115
Cdd:PLN00028 43 ISFFTCFVSTFA----AAPLLPIIRDNLNLTKSdigNAGIA-SVSGSIFS--RLAMGPVCDLYGPRYGSAFLLMLTAPAV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 116 LLSTMMTSWHGILIMRALIGLSLSGVAAvGMTYLSEEIHPSFVAFSMGLYIS-GNSIGGMSGRLISGVF--------TDF 186
Cdd:PLN00028 116 FCMSLVSSATGFIAVRFFIGFSLATFVS-CQYWMSTMFNGKIVGTANGIAAGwGNLGGGVTQLLMPLVFplikdagaPSF 194
|
170 180
....*....|....*....|.
gi 446013974 187 FNWRIALAAIGCFALASALMF 207
Cdd:PLN00028 195 TAWRIAFFVPGLLHIIMGILV 215
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
64-131 |
3.43e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 45.65 E-value: 3.43e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446013974 64 QEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMR 131
Cdd:PRK11043 34 ADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLR 101
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
49-212 |
4.00e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 45.24 E-value: 4.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 49 FALLYCVQPILPV----LSQEFGLTPANSSISLSIstamLAIGLLFT----GPLSDAIGRKPVMVTALLLASICTLLSTM 120
Cdd:cd17380 8 TCICYADRVNMPIaivpMAKEFGWSKTDQGLVLSS----FFWGYALTqvlgGYLADRFGGKKVLLLAVALWSLATLLTPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 121 MTSWH--GILIMRALIGLsLSGVAAVGMTYL-SEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIG 197
Cdd:cd17380 84 LAYSSlpLLILSRILLGL-GEGVHFPSMTSLfSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFG 162
|
170
....*....|....*
gi 446013974 198 CFALASALMFWKILP 212
Cdd:cd17380 163 LLGLLWALVWLIYLP 177
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-213 |
4.37e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 45.37 E-value: 4.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 31 TPQFMRVTLalFSAGLATFALL--YCVQPILPV-LSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTA 107
Cdd:cd17371 204 SPPLLRTTL--LASLLATGALGgyYGITTWLPSyLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALF 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 108 LLLASICTLLSTMMT-SWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDF 186
Cdd:cd17371 282 ALGSAISILLYFFLPlSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATS 361
|
170 180
....*....|....*....|....*..
gi 446013974 187 FNWRIALAAIGCFALASALMFWKILPE 213
Cdd:cd17371 362 GSLGTAIAVFAAVYYIAGLVLALLLPE 388
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
61-205 |
5.32e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.90 E-value: 5.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 61 VLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMM--TSWHGILIMRALIGLSL 138
Cdd:cd17316 203 YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFV 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446013974 139 SGVAAVGMTYLSEEIHPSFVAFSMGL-YISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASAL 205
Cdd:cd17316 283 GGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
34-217 |
5.37e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 45.35 E-value: 5.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 34 FMRVTLALFSAGLATFALLYcvqpILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASI 113
Cdd:TIGR01299 169 FFVLGLALMADGVEVFVVGF----VLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGF 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 114 CTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEI-------HPSFVAfsMGLYISGNSIGGMSGRLIS------ 180
Cdd:TIGR01299 245 FAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLaqekrgeHLSWLC--MFWMIGGIYAAAMAWAIIPhygwsf 322
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 446013974 181 --GVFTDFFNWR--IALAAIGCFALASALMFwkiLPESRHF 217
Cdd:TIGR01299 323 qmGSAYQFHSWRvfVIVCAFPCVFAIGALTF---MPESPRF 360
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
38-208 |
5.90e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.93 E-value: 5.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 38 TLALFSAGLATFALlycvQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLL 117
Cdd:cd17341 5 WLSFFLGFMVWFLF----APLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 118 STM-MTSWHGILIMRALIGLSLsGVAAVGMTYLSEEIHPS-FVAFSMGLYISGNSIGGMSGRLISGVF------TDFFNW 189
Cdd:cd17341 81 LALaVSSYWGLLVLGFLLGFAG-ANFASGQPWASFWFPKEkIGGAAGGIAGAGNMGVAVSQLLAPLIAgaivfdGGFVGW 159
|
170
....*....|....*....
gi 446013974 190 RIALAAIGCFALASALMFW 208
Cdd:cd17341 160 RNAFFVPGILLAIAAVLVL 178
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
40-210 |
6.24e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 44.76 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 40 ALFSAGLAT---FALLYcvqpilpvLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTL 116
Cdd:COG2270 248 FFYRDGVQTviaFAGIY--------AAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCL 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 117 LSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYisgnsigGMSGRLIS-------GVFTDFF-N 188
Cdd:COG2270 320 AAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLY-------ALSGKAASflgpllfGLVTQLTgS 392
|
170 180
....*....|....*....|..
gi 446013974 189 WRIALAAIGCFALASALMFWKI 210
Cdd:COG2270 393 QRLGILSLIVFFVIGLVLLLRV 414
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
39-206 |
8.38e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 44.23 E-value: 8.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 39 LALFSAGLATFALLYCVQPILpvlSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLS 118
Cdd:cd17333 206 LALFLYVGAETAFSSWVPSYL---VEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLIL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 119 TMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIhPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGC 198
Cdd:cd17333 283 LLAPTLVVGLVATALLGLFMAALFPTILSLGISNL-PYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITI 361
|
....*...
gi 446013974 199 FALASALM 206
Cdd:cd17333 362 LYAIIFVL 369
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
34-182 |
9.27e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.11 E-value: 9.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 34 FMRVTLALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASI 113
Cdd:cd17365 169 LLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAV 248
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446013974 114 CT-LLSTMMTSWHGILIMRALIGLSLSGvAAVGMTYLSEEIHPSFV-AFSMGLYISGNSIGGMSGRLISGV 182
Cdd:cd17365 249 SLaLLGVSPASLVLLYVLVFLAGACVNG-AQVGLYALAARFYPTEVrATGVGWALGVGRLGAILGPLLGGL 318
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
56-407 |
9.51e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.13 E-value: 9.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 56 QPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPvmvtALLLASICTLLS-TMMTSWHGILImrali 134
Cdd:cd17331 20 QPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRA----ALVLSFLSSALSyLLLAFASSVPM----- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 135 gLSLSGVAAVGM-------TYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMF 207
Cdd:cd17331 91 -LFLSRLPSVFMhamqaaqMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 208 WKILPES-----RHFRPTSLRPKSLFIN--FRLHWRDRGLPllfaegFLLMGSFVTLFNYIGYRLMLS-----PWHVSQA 275
Cdd:cd17331 170 ILLIPSNtkskrEKEAKESASPPSVFNLkeILRLLRLPGVA------FLLLVKLLSGLPIGMFQSMFSlvamdFFGLTPE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 276 VVG-LLSLAYLTGTWS-SPKAGTMTTRYGRGPVMLFSTGVMLFG-LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIG 352
Cdd:cd17331 244 ENGyLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGyLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLT 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446013974 353 PRA-KRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVG---AFIALMLVIALLV 407
Cdd:cd17331 324 KAVpPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGllgAAINGLLTVYLLL 382
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
89-208 |
9.94e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.08 E-value: 9.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 89 LFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIhPSFVAFSMGLYISG 168
Cdd:cd17471 253 LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLM-PGQPGLATTLYSNA 331
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 446013974 169 NSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFW 208
Cdd:cd17471 332 SRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
55-401 |
1.32e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 43.71 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 55 VQPILPVLSQEFGltpANSSISLSISTAML--AIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRA 132
Cdd:cd17502 15 VATALPTIVAEFG---GLSLVSWVGTAYLLtsTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 133 LIGLSLSGVAAVGMTYLSEEIHPS----FVAFSMGLYisgnSIGGMSGRLISGVFTDFFNWR----IALaAIGCFALASA 204
Cdd:cd17502 92 IQGIGGGGLMSLAFIIIADLVPPRergkYQGYIGAVF----GIASVAGPLIGGAFTDHLSWRwcfyINL-PIGGLALALL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 205 LMFWkilpesrhfrptslrpkslfinfrlhwrdrglpLLFAEGFLLMGSFVTLFNYIGYRLML----SPWHvSQAVVGLL 280
Cdd:cd17502 167 RTIL---------------------------------LSSIFGFLFGGALFGLIYYLPLYFQLvlgdSATK-SGVRLLPL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 281 SLAYLTGTWSSPKAGTMTTRYgrGPVMLFSTGVMLFG----LLMTLFSSLWLIFAGMLLFSAGF---FAAHSVASSWIGP 353
Cdd:cd17502 213 IIGLVIGSIISGALISKTGRY--KPLIVIGTILMSVGagllTTLTLDTSKWLLIGYLILLGLGLgigFQQPLVAVQNAVP 290
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446013974 354 RAKRakGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALML 401
Cdd:cd17502 291 PADV--GVATATNTFFRSLGGTLGVAITDVFLVALALAALAFLLSLFL 336
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
85-230 |
1.50e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 43.79 E-value: 1.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 85 AIGLLFTGPLSDAIGRKPVMV---TALLLASICTLLSTMMTSWHGILIMRALIGLSLS-GVAAVGMtYLSeEIHPSFVAF 160
Cdd:cd17357 63 AIGSFISAFLANRFGRKNGLLisnALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGlSTGFVPM-YLQ-EISPSELRG 140
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446013974 161 SMGLYisgNSIGGMSGRLISGVFT------DFFNWRIALAAIGCFALASALMFWkILPESrhfrptslrPKSLFIN 230
Cdd:cd17357 141 ALGSL---TQIGVTLGILLGQVFGlpsvlgTETLWPYLLFFPGIPALLQLAALP-FFPES---------PKFLLIS 203
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
74-174 |
1.90e-04 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 43.23 E-value: 1.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 74 SISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEI 153
Cdd:cd17377 42 SLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECV 121
|
90 100
....*....|....*....|.
gi 446013974 154 HPSFVAFSmglyisgNSIGGM 174
Cdd:cd17377 122 GKSYWALA-------GSLGGL 135
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
58-219 |
2.22e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 43.02 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 58 ILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLS 137
Cdd:cd17476 20 ILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 138 L-----SGVAAVGMTYLSeeihPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIA--LAAIGCFALASALMFWKi 210
Cdd:cd17476 100 PafllpNAMALLGRTYPP----GPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIfwFLAILAAIVAVAAIFWT- 174
|
....*....
gi 446013974 211 lpeSRHFRP 219
Cdd:cd17476 175 ---SPSFIA 180
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
48-190 |
2.48e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 42.99 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 48 TFALLYCVQPILPVLSQEFGLTPAN-----SSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMT 122
Cdd:PRK09874 26 TGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQ 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446013974 123 SWHGILIMRALIGLsLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWR 190
Cdd:PRK09874 106 NIWQFLILRALLGL-LGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLR 172
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
86-406 |
2.50e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.90 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 86 IGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGI--------LIMRALIGLSLSGVAAVGMTYLSEEIHPSf 157
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQIgilapillVLLRLLQGLALGGEWGGAVLMAVEHAPPK- 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 158 vafSMGLYISGNSIGGMSGRLIS-GVF--------TDFFN---WRIAlaaigcFALASALMFWKI-----LPESRHFRPT 220
Cdd:cd17369 138 ---RRGFYGSFPQLGAPVGLLLAtGVFlllsallsDEAFLswgWRIP------FLLSAVLVAVGLyirlrLEETPVFRRA 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 221 ----SLRPKSLFINFRLHWRD--RGLPLLFAEG--FLLMGSFVTlfNYIGYRLMLSPwhvsQAVVGLLSLAYLTGTWSSP 292
Cdd:cd17369 209 keagQVVRAPLVEVLRRHWRAllLAIGLRLAENvlFYLFTTFAL--SYATQTLGVDR----STVLLAVLIASVVAAITIP 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 293 KAGTMTTRYGRGPVMLFST-GVMLFG----LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIG---PRAKRAKGQAss 364
Cdd:cd17369 283 LFGWLSDRVGRRPVYLAGAlLAALFAfpffWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAelfPTRVRYTGAS-- 360
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446013974 365 lylFSYYLGSSIAGTLG-----GVFWHNYGWNGVGAFIALMLVIALL 406
Cdd:cd17369 361 ---LGYQLGAILGGGFApliatALVAATGSWWPVALYLAALAVISLV 404
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
42-207 |
2.70e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.00 E-value: 2.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 42 FSAGLATFALLYCVQ---PILPVLSQEFGLTPANSSISLSISTAMlAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLS 118
Cdd:cd06179 1 AALCLAYFAQLFGVTlpaAVLPFIVADLGPSSNSTWISTAWSLAQ-AVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 119 TMMTSWHGILIMRALIGLSlSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFT--DFFNWR-IALAA 195
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIG-AGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRwIFYIN 158
|
170
....*....|..
gi 446013974 196 IGCFALASALMF 207
Cdd:cd06179 159 AIFNALALILLF 170
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
39-217 |
2.97e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 42.95 E-value: 2.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 39 LALFSAGLATFALLYCV-------QPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVM-VTALLL 110
Cdd:cd17358 2 LATFVANLGSFSFGIAVgwsspalPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLlISAIPC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 111 ASICTLLSTMMTSWHgILIMRALIGLSLSGVAAVGMTYLSeEIHPSFVAfsmGLYISGNSIGGMSGRLISGVFTDFFNWR 190
Cdd:cd17358 82 ILGWLLIAFAKDVWM-LYLGRFLAGFGGGAASVVVPVYIA-EIAPKNVR---GALGSLNQLLVNIGILLGYVLGSFLPWR 156
|
170 180
....*....|....*....|....*..
gi 446013974 191 IaLAAIGCFALASALMFWKILPESRHF 217
Cdd:cd17358 157 T-LALIGAIPPVVFLILLFFIPESPRW 182
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
49-413 |
5.44e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.80 E-value: 5.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 49 FALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIG-RKPVMVTALLLASICTL-LSTMMTSWHG 126
Cdd:cd17335 10 FAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLsLFFVAQIFWL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 127 ILIMRALiGLSLSGVA-----AVGMTYLSEEihpsfvAFSMGLYISGNSIGGMSGRLISGVFTDffNWRIALAAIGCFAL 201
Cdd:cd17335 90 LLLLVIL-GAFFSAPVvplvdSITLQYLGEE------RERYGKQRLWGSIGFGIAALLVGILID--RSSTYKNYTIAFYV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 202 ASALMFWKILPESR-HFRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYigYRLMLSPWHVSQAVVGLL 280
Cdd:cd17335 161 FAVLMLLALLLALKfPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSF--LFWHLQDLGGSKTLIGLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 281 S-LAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFG-LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIG---PRA 355
Cdd:cd17335 239 WtVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRwLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASaaaPPG 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446013974 356 KRAKGQAsSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLVGTRLHR 413
Cdd:cd17335 319 LRATAQG-LLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
49-389 |
6.83e-04 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 41.46 E-value: 6.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 49 FALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIG-RKPVMVTALLLASICTLLSTMMTSWHGI 127
Cdd:pfam12832 12 FAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGkRKAVVRLASILAAVLFLSVLFIPISLTF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 128 LIMRALIGL-------SLSGVAAVGMTYLSEEIHpsfvafSMGLYISGNSIGGMSGRLISGVFTDFfnWRIALAAIGCFA 200
Cdd:pfam12832 92 WWLALLVVLfsffwnaILPQFEVATLQHLGEKRK------DYGRQRLWGSVGFALSVFGLGALFDH--YSVGLLPSVLFY 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 201 LASALMFWKILPESRHFRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYigYRLMLSPWHVSQAVVGLL 280
Cdd:pfam12832 164 LFAALMLLSLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTF--LFLYLENLGASNTLLGAL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 281 ----SLAYLTGTWSSPKagtMTTRYGRGPVMLFSTGVM--LFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPR 354
Cdd:pfam12832 242 walgVVAEIPLFFYAHR---LLRRFGHRNLLIIALLLTalRWLLYAFFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRI 318
|
330 340 350
....*....|....*....|....*....|....*..
gi 446013974 355 A-KRAKGQASSLY-LFSYYLGSSIAGTLGGVFWHNYG 389
Cdd:pfam12832 319 FpGSLQGTGQALYsGLYFGLGGALGSLIGGQLWDLFG 355
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
39-215 |
7.33e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 7.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 39 LALFSAGLATFALLycvqPILPVLSQEF---GLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICT 115
Cdd:cd17330 3 LVVFLDALGFGIVF----PVLPFYVREFnklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 116 LLSTMMTSWHGILIMRALIGLsLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAA 195
Cdd:cd17330 79 VLLGLSRNLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
|
170 180
....*....|....*....|
gi 446013974 196 IGCFALASALMFWKILPESR 215
Cdd:cd17330 158 AAALALLNLVLVLFFLPPLR 177
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
249-416 |
7.65e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.26 E-value: 7.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 249 LLMGSFVTLFNYIGYRLMLSPW----HVSQAVVGLLSLAYLTGTW-SSPKAGTMTTRYGRGPVMLFSTGVM-LFGLLMTL 322
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALlqsfGLSASQLGLLFALFSLGYAlLQPLAGLLADRFGRRPVLLLGLLLFaLGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 323 FSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRAK-RAKGQASSLYLFSYYLGSSIAGTLGGVF--WHNYGWNGVGAFIAL 399
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170
....*....|....*..
gi 446013974 400 MLVIALLVGTRLHRRLH 416
Cdd:cd06174 161 LALLAAILLLLVVPDPP 177
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
31-182 |
8.80e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.19 E-value: 8.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 31 TPQFMRVTLALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLL 110
Cdd:TIGR00895 245 QGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLG 324
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446013974 111 ASICTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGV 182
Cdd:TIGR00895 325 AVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGY 396
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
55-408 |
1.07e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 41.02 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 55 VQPILPVLSQEFGLTpaNSSISLSISTAMLAIGLLftGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGI---LIMR 131
Cdd:cd17339 18 VGPLLPEIRDDLGLS--ASQAGLLTTLPLLCFAVF--SPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIallFLGT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 132 ALIGLSLsGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTD--FFNWRIALAAIGCFALAsALMFWK 209
Cdd:cd17339 94 ALAGAGI-AVGNVLLPSLIKRDFPRRVGLMTGLYTTSMNLGAALASGLSVPLAQalGGGWRGALAIWALPALL-ALLIWL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 210 ILPESRHFRPTSLRPKSlfinFRLHWRDR---------GLPLLFAegFLLMGSFVTLFNYIGYRLMLSPWhvsqaVVGLL 280
Cdd:cd17339 172 PQLRRRKRAAAAAAPLT----KISVWRSPlawqvtlfmGLQSLLF--YTLMAWLPTILIDAGLSAATAGW-----LLSLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 281 SLAYLTGTWSSPKAGTMTTryGRGPVMLFSTGVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRAkRAKG 360
Cdd:cd17339 241 QLVGIPASLLVPILATRLK--NQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLLGLGGGAAFSLALTLISLRS-SDPA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446013974 361 QASSLYLFSYYLGSSIAGT----LGGVFWHNYGWNGVGAFIALMLVIALLVG 408
Cdd:cd17339 318 EAAALSGMAQSVGYLLAALgpllFGVLHDLTGSWTAPLVLLLALTVLQLVAG 369
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
35-258 |
1.13e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 40.75 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 35 MRVTLALFSA-GLATFALlycvQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASI 113
Cdd:cd06180 1 LAGALALAVAmGIGRFAY----TPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 114 CTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIG-GMSGRLISGVFTDFFNWRIA 192
Cdd:cd06180 77 LLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGiALSGLLVPAGLGGGLSWRAG 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446013974 193 LAAIGCFALASALMFWKILPESRHFRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLF 258
Cdd:cd06180 157 WLALALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLI 222
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
67-214 |
1.75e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 40.31 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 67 GLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLS-TMMTSWHGILIMRALIGLSLSGVAAVG 145
Cdd:cd17356 41 YPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQvAAIGKWYQLIVGRIIAGLGVGFASVLV 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446013974 146 MTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLIS---GVFTDFFNWRIALAAigCFALASALMFWKI-LPES 214
Cdd:cd17356 121 PVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINygtHKLDGSAQWRIPLGL--QIVWGLLLLIGMFfLPES 191
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
36-208 |
2.28e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 36 RVTLALFSAGLATFALLYCVQPILP-VLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASIC 114
Cdd:cd17473 197 KRVLPIYFLAFLAMLLFYVIPIQLPfLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 115 TLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVF-TDFFNWRIAL 193
Cdd:cd17473 277 FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLvNLTGGLSGAF 356
|
170
....*....|....*
gi 446013974 194 AAIGCFALASALMFW 208
Cdd:cd17473 357 LILGVLALVLAIVLL 371
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
30-210 |
2.65e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.56 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 30 GTPQFMRVTLALFSAGLATFALlycvQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALL 109
Cdd:cd17355 208 RSASFWLLALAFFLCGFAVVGL----IVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYA 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 110 LASICTLLSTMMT-SWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFF- 187
Cdd:cd17355 284 LRALGLALLLLLPfPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTg 363
|
170 180
....*....|....*....|...
gi 446013974 188 NWRIALAAIGCFALASALMFWKI 210
Cdd:cd17355 364 SYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
78-340 |
3.05e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 39.56 E-value: 3.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 78 SISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSLsGVAAVGMTYLSEEIHPSF 157
Cdd:cd17360 42 SSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGV-GIASMTVPLYIAEAAPPR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 158 VafsMGLYISGNSIGGMSGRLISGVFTDFFN-----WRI--ALAAIGCFALASALMFwkiLPESRHFRPTSlrpKSLFIN 230
Cdd:cd17360 121 I---RGRLVTINVLFITGGQFVAYVINGAFSylpggWRWmlGLAAVPAVLQFIGLLF---LPESPRWPSTR---RALIVG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 231 FRLHWRDRglpllFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQAVVGLLSLAYLTGTWSspkagtmTTRYGRGPVMLFS 310
Cdd:cd17360 192 CGLQAFQQ-----FSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYL-------IDKFGRRKLLLIS 259
|
250 260 270
....*....|....*....|....*....|
gi 446013974 311 TGVMLFGLLMTlfsSLWLIFAGMLLFSAGF 340
Cdd:cd17360 260 LFGVIVALVVL---AVWLALVGLILYLAFF 286
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
34-217 |
3.25e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 39.52 E-value: 3.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 34 FMRVTLALFSAGLATFALLYcvqpILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASI 113
Cdd:cd17438 1 FFVLGLALMADGVEVFVVGF----VLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINAS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 114 CTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEI-------HPSFVAfsMGLYISGNSIGGMSGRLIS------ 180
Cdd:cd17438 77 FAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLarekrgeHLSWLC--MFWMIGGLYASAMAWSIIPhygwgf 154
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 446013974 181 --GVFTDFFNWR--IALAAIGCFALASALMFwkiLPESRHF 217
Cdd:cd17438 155 smGTNYHFHSWRvfVIICALPCIASIIALKF---MPESPRF 192
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
59-392 |
3.35e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 39.28 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 59 LPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSL 138
Cdd:TIGR00881 18 MPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 139 SGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGV-FTDFFNWRIALAAIGCFALASALMFWKILPESRhf 217
Cdd:TIGR00881 98 GMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSP-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 218 RPTSLRPKSLfinfrlhWRDRGLPLLFAEGFLLMGSFVTLFNYIgyrlMLSP--WHVSQAVVGLLSLAYLTGTW------ 289
Cdd:TIGR00881 176 QSCGLPPAEE-------MPNEEPDGDAEKKEEELTKKQIFLQYV----LLNKvlWYISLGYVFVYVVRTGILDWsplylt 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 290 -----SSPKAGTMTTRY---------------------GRGPV-MLFSTGVMLFGLLMTLFSSLWLIFAGMLLFSAGFF- 341
Cdd:TIGR00881 245 qekgfSKEKASWAFTLYelgglvgtllagwlsdklfngRRGPLaVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLv 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446013974 342 ----AAHSVASSWIGPraKRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNG 392
Cdd:TIGR00881 325 ygpqMLIGVIASELAP--KKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAG 377
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
52-134 |
4.49e-03 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 39.18 E-value: 4.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 52 LYCVQPILPVLSQEFGLTPAN--SSISLSISTAML---AIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHG 126
Cdd:cd17364 15 LFSISLVTKILGRLYYGGKGSlpSGVSGLVNAAALvgtIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTP 94
|
....*...
gi 446013974 127 ILIMRALI 134
Cdd:cd17364 95 LGVMGWLI 102
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
271-411 |
5.19e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 38.71 E-value: 5.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 271 HVSQAVVGLLSLAY-LTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFG-LLMTLFSSLWLIFAGMLLFSAGFFAAHSVAS 348
Cdd:cd17325 27 GASVAQIGLIVAAYaLAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVStLLFAFATSYWQLLLARFLQGLASAAVWPAAM 106
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446013974 349 SWIGPRAKRAK-GQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLVGTRL 411
Cdd:cd17325 107 ALIADIAPPEErGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLL 170
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
74-380 |
5.88e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 38.77 E-value: 5.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 74 SISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEI 153
Cdd:cd17327 44 NWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWY 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 154 HPSFVAFSMGLYISGNSIGGMSGRLIS-GVFT-----DFFNWRIALAAIGC--FALASALMFW----------------- 208
Cdd:cd17327 124 KREEQAKRIAFFYAAAGLGSIFGGLLAyGVFKilgvgGLAGWRWLFIIEGLitIIIGLVIFFWlpdnpskawflteeeke 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 209 ---KILPESRHFRPTSLRPKSLFINFRLHWRdrgLPLLFAEGFLLMGSFVTLFNYigYRLMLSPWHVSQAVVGLLSLA-Y 284
Cdd:cd17327 204 lavERLRANQTGKGDQKFKWKQIKEAFKDPR---TWLLFLFFFCSQITNNGISNF--LPLILKSLGFYSLQTNLLSVPiG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 285 LTGTWSSPKAGTMTTRY-GRGPVMLFSTGVMLFGLLMTLFSSL-WLIFAGMLLFSAGFFAAHSVASSWI----GPRAKRA 358
Cdd:cd17327 279 ALGAVSLLIAALLSDRFkKRGLFAIFACVLALVGSIILLAAPNpPGAYFAAYILGGGSYAGFPILLSWIssncAGYTKRA 358
|
330 340
....*....|....*....|..
gi 446013974 359 kgQASSLYLFSYYLGSSIAGTL 380
Cdd:cd17327 359 --TVLAIMLIFYNVGNIVAPQI 378
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
32-184 |
6.27e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 38.73 E-value: 6.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 32 PQFMRVTLALFSAGLATFALLycvQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLA 111
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVA---ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446013974 112 SICTLLSTMM--TSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAF---SMGLYISGNSIGGMSGRLISGVFT 184
Cdd:COG2211 305 ALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrREGLYFGIFTFAIKLGQALAGALA 382
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
39-214 |
6.46e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 38.84 E-value: 6.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 39 LALFSAGLATFAL-----LYCVQPILPVLSQEFGLTPANS-SISLSISTAMLA--IGLLFTGPLSDAIGRKPVMVTALLL 110
Cdd:TIGR00898 87 LKLSDLGLAATEPcldgwEYSYDTFSSTIVTEWDLVCEDAwKVDLTQSCFFVGvlLGSFVFGYLSDRFGRKKVLLLSTLV 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 111 ASICTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMsgrLISGVFTDFFNWR 190
Cdd:TIGR00898 167 TAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLV---LLPLVAYFIPDWR 243
|
170 180
....*....|....*....|....
gi 446013974 191 IALAAIGCFALASALMFWkILPES 214
Cdd:TIGR00898 244 WLQLAVSLPTFLFFLLSW-FVPES 266
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
156-395 |
7.43e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.35 E-value: 7.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 156 SFVAFSMGLYISGNSIGGMSGRLISGVFTD---FFNWRIALAAIGCFALASALMFWKILPESRHFRPTSLRPKSLFINFR 232
Cdd:cd17332 136 SLTSWRMFFATIGGLLVTVLPPPLVAYFGGgnaSRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLK 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 233 LHWRDRGLPLLFAEGFLLMGSFVTLFNYIGY---RLMLSPWHVSQAVVGLLSLAYLTGTWSSPKagtmTTRYGRGPVMLF 309
Cdd:cd17332 216 ALLKNRPFLILLLAYLLYFLAFNIVNTVLVYyfkYVLGGRAELVLLLLLILSGALLALLPWPPL----KKRFGKKKAFFI 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 310 STGVMLFGLLMTLF---SSLWLIFAGMLLFSAGFFAAHSVASSWIG--------PRAKRAKGQASSLYLFSYYLGSSIAG 378
Cdd:cd17332 292 GLLLAILGLLLLFFlppGNLVLILVLAVLAGIGYGGANLLPWAMLAdvidygelKTGKRREGIFYSVMTFFRKLGLALAG 371
|
250
....*....|....*..
gi 446013974 379 TLGGVFWHNYGWNGVGA 395
Cdd:cd17332 372 ALVGLILSLAGYVANAA 388
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
36-210 |
7.87e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.36 E-value: 7.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 36 RVTLALFSAGLATFALLYCVQPILPV-LSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASIC 114
Cdd:cd17329 200 RAFLLFLLASFLISLIYFQLESTLPVyVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIG 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 115 TLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALA 194
Cdd:cd17329 280 FAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWL 359
|
170
....*....|....*.
gi 446013974 195 AIGCFALASALMFWKI 210
Cdd:cd17329 360 ILAALGLIAAALLLGL 375
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
60-205 |
8.79e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 37.97 E-value: 8.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 60 PVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPL-SDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSL 138
Cdd:cd17490 219 PLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLfYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGT 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446013974 139 SGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASAL 205
Cdd:cd17490 299 GILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAI 365
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
39-151 |
9.63e-03 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 38.09 E-value: 9.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 39 LALFSAGLATFALLYcvqpILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLS 118
Cdd:cd17439 6 LALMADGVEVFVVGF----VLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFS 81
|
90 100 110
....*....|....*....|....*....|...
gi 446013974 119 TMMTSWHGILIMRALIGLSLSGVAAVGMTYLSE 151
Cdd:cd17439 82 SFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSE 114
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
55-407 |
9.77e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.01 E-value: 9.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 55 VQPILPVLSQEFGLTPAN-----SSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILI 129
Cdd:cd17391 15 IAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 130 MRALIGLsLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALM--F 207
Cdd:cd17391 95 LRLLQGV-FSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLtlF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 208 W---KILPESRHfrpTSLRPKSLFinfrlhwrdRGLPllfaEGFLLMGSFVTLFNYIGYRLMLSP---WHVSQAVVGLLS 281
Cdd:cd17391 174 FvkeDFKPVEKK---KMVSTKEVW---------NSVP----NPSLLISLFVTTFIIQLANQSIEPiltLYIRQLMGDASN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 282 LAYLTG----------TWSSPKAGTMTTRYG-RGPVMLFSTGVMLFGLLMTLFSSLWLIfaGMLLFSAGFFAAHSVASSW 350
Cdd:cd17391 238 LAFISGlvfsatgvssLLSAPRLGKLGDRIGhHRILLGALLASALLYIPQAFVQTPWQL--GILRFLLGLATGGLLPAIN 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013974 351 IGPRAKRAKGQASSLYLFS---YYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLV 407
Cdd:cd17391 316 SLLAKITPKEVAGRIFGYNqsfQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIW 375
|
|
| |
