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Conserved domains on  [gi|446019740|ref|WP_000097595|]
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MULTISPECIES: NADP-dependent phosphogluconate dehydrogenase [Bacillales]

Protein Classification

NADP(+)-dependent, decarboxylating phosphogluconate dehydrogenase( domain architecture ID 11483768)

NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate, as part of the oxidative branch of the pentose phosphate pathway

CATH:  3.40.50.720|1.20.5.320
EC:  1.1.1.44
Gene Ontology:  GO:0004616|GO:0050661|GO:0006098|GO:0046177
PubMed:  35234135|34709178|26479318
SCOP:  3000048

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
13-468 0e+00

NADP-dependent phosphogluconate dehydrogenase;


:

Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 843.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  13 MGKNLAWNIEDKKYSVSIHSRDNNEINDTIQ-KSHYQKIYPAYNLKEFVDSLEKPRKILLMIKAGSPTDNMINTLLPLLD 91
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAeEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  92 DDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAISAKAQDGASCVTY 171
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 172 IGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKDLLGMSHTEISQTFKDWNAGELESYLIEITGDIFTELD-ENNEPLVE 250
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDeETGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 251 KILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKSLNGPQASFDGNKEEFLEKIRKALYMSKIC 330
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAEFIEDVRQALYASKIV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 331 SYAQGFAQMRKASEDHEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDPYFKNIVTDYQEALRDVVATG 410
Cdd:PRK09287 321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446019740 411 VKNGVPTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDHEGVFHTQWDEE 468
Cdd:PRK09287 401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEWSED 458
 
Name Accession Description Interval E-value
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
13-468 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 843.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  13 MGKNLAWNIEDKKYSVSIHSRDNNEINDTIQ-KSHYQKIYPAYNLKEFVDSLEKPRKILLMIKAGSPTDNMINTLLPLLD 91
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAeEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  92 DDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAISAKAQDGASCVTY 171
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 172 IGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKDLLGMSHTEISQTFKDWNAGELESYLIEITGDIFTELD-ENNEPLVE 250
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDeETGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 251 KILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKSLNGPQASFDGNKEEFLEKIRKALYMSKIC 330
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAEFIEDVRQALYASKIV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 331 SYAQGFAQMRKASEDHEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDPYFKNIVTDYQEALRDVVATG 410
Cdd:PRK09287 321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446019740 411 VKNGVPTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDHEGVFHTQWDEE 468
Cdd:PRK09287 401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEWSED 458
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 1-465 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 842.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740   1 MSSNIGILGLGVMGKNLAWNIEDKKYSVSIHSRDNNEINDTIQK-SHYQKIYPAYNLKEFVDSLEKPRKILLMIKAGSPT 79
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEhGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  80 DNMINTLLPLLDDDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAIS 159
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 160 AKAqDGASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKDLLGMSHTEISQTFKDWNAGELESYLIEITGDIFT 239
Cdd:COG0362  161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 240 ELD-ENNEPLVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKSLNGP-QASFDGNKEEFL 317
Cdd:COG0362  240 KKDpETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPeAAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 318 EKIRKALYMSKICSYAQGFAQMRKASEDHEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDPYFKNIVT 397
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446019740 398 DYQEALRDVVATGVKNGVPTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDHEGVFHTQW 465
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 4-465 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 717.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740    4 NIGILGLGVMGKNLAWNIEDKKYSVSIHSRDNNEINDTIQK-SHYQKIYPAYNLKEFVDSLEKPRKILLMIKAGSPTDNM 82
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEeAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740   83 INTLLPLLDDDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAISAKA 162
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  163 qDGASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKDLLGMSHTEISQTFKDWNAGELESYLIEITGDIFTELD 242
Cdd:TIGR00873 161 -DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  243 ENNEPLVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKSLNGPQASFDG-NKEEFLEKIR 321
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGvDKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  322 KALYMSKICSYAQGFAQMRKASEDHEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDPYFKNIVTDYQE 401
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446019740  402 ALRDVVATGVKNGVPTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDHEG--VFHTQW 465
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNW 465
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 178-465 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 570.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  178 GHYVKMVHNGIEYADMQLIAESYAMMKDLLGMSHTEISQTFKDWNAGELESYLIEITGDIFTELDENN-EPLVEKILDTA 256
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEDgKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  257 GQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKSLNGP-QASFDGNKEEFLEKIRKALYMSKICSYAQG 335
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPpPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  336 FAQMRKASEDHEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDPYFKNIVTDYQEALRDVVATGVKNGV 415
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 446019740  416 PTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDHEGVFHTQW 465
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
 
Name Accession Description Interval E-value
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
13-468 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 843.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  13 MGKNLAWNIEDKKYSVSIHSRDNNEINDTIQ-KSHYQKIYPAYNLKEFVDSLEKPRKILLMIKAGSPTDNMINTLLPLLD 91
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAeEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  92 DDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAISAKAQDGASCVTY 171
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 172 IGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKDLLGMSHTEISQTFKDWNAGELESYLIEITGDIFTELD-ENNEPLVE 250
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDeETGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 251 KILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKSLNGPQASFDGNKEEFLEKIRKALYMSKIC 330
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAEFIEDVRQALYASKIV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 331 SYAQGFAQMRKASEDHEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDPYFKNIVTDYQEALRDVVATG 410
Cdd:PRK09287 321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446019740 411 VKNGVPTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDHEGVFHTQWDEE 468
Cdd:PRK09287 401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEWSED 458
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 1-465 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 842.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740   1 MSSNIGILGLGVMGKNLAWNIEDKKYSVSIHSRDNNEINDTIQK-SHYQKIYPAYNLKEFVDSLEKPRKILLMIKAGSPT 79
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEhGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  80 DNMINTLLPLLDDDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAIS 159
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 160 AKAqDGASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKDLLGMSHTEISQTFKDWNAGELESYLIEITGDIFT 239
Cdd:COG0362  161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 240 ELD-ENNEPLVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKSLNGP-QASFDGNKEEFL 317
Cdd:COG0362  240 KKDpETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPeAAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 318 EKIRKALYMSKICSYAQGFAQMRKASEDHEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDPYFKNIVT 397
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446019740 398 DYQEALRDVVATGVKNGVPTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDHEGVFHTQW 465
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 4-465 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 717.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740    4 NIGILGLGVMGKNLAWNIEDKKYSVSIHSRDNNEINDTIQK-SHYQKIYPAYNLKEFVDSLEKPRKILLMIKAGSPTDNM 82
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEeAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740   83 INTLLPLLDDDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAISAKA 162
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  163 qDGASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKDLLGMSHTEISQTFKDWNAGELESYLIEITGDIFTELD 242
Cdd:TIGR00873 161 -DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  243 ENNEPLVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKSLNGPQASFDG-NKEEFLEKIR 321
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGvDKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  322 KALYMSKICSYAQGFAQMRKASEDHEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDPYFKNIVTDYQE 401
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446019740  402 ALRDVVATGVKNGVPTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDHEG--VFHTQW 465
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNW 465
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 3-465 0e+00

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 594.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740   3 SNIGILGLGVMGKNLAWNIEDKKYSVSIHSRDNNEINDTIQKSHYQ--KIYPAYNLKEFVDSLEKPRKILLMIKAGSPTD 80
Cdd:PTZ00142   2 SDIGLIGLAVMGQNLALNIASRGFKISVYNRTYEKTEEFVKKAKEGntRVKGYHTLEELVNSLKKPRKVILLIKAGEAVD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  81 NMINTLLPLLDDDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAISA 160
Cdd:PTZ00142  82 ETIDNLLPLLEKGDIIIDGGNEWYLNTERRIKRCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCSA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 161 KAQDgASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKDLLGMSHTEISQTFKDWNAGELESYLIEITGDIFTE 240
Cdd:PTZ00142 162 KVGD-SPCVTYVGPGSSGHYVKMVHNGIEYGDMQLISESYKLMKHILGMSNEELSEVFNKWNEGILNSYLIEITAKILAK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 241 L-DENNEPLVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKSLNGPQAS---FDGNKEEF 316
Cdd:PTZ00142 241 KdDLGEEHLVDKILDIAGSKGTGKWTVQEALERGIPVPTMAASVDARNISALKEERTKASSHLAGPNPAnktETEDKKYF 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 317 LEKIRKALYMSKICSYAQGFAQMRKASEDHEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDPYFKNIV 396
Cdd:PTZ00142 321 IDDLKNALYCSKIISYTQGFFLIKEASKEFGWNLNLGEIARIWRGGCIIRAVFLDRIKNAFKKNPQLDLLFLDPDFNDEL 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446019740 397 TDYQEALRDVVATGVKNGVPTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDHEGVFHTQW 465
Cdd:PTZ00142 401 KNKQPSWRKVVSMATKNGIPTPAFSASLAYYQMYRSQNLPANLVQAQRDYFGAHTYKRLDRPGAFHTNW 469
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 1-467 0e+00

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 592.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740   1 MSSNIGILGLGVMGKNLAWNIEDKKYSVSIHSRDNNEINDTIQKSHYQ---KIYPAYNLKEFVDSLEKPRKILLMIKAGS 77
Cdd:PLN02350   5 ALSRIGLAGLAVMGQNLALNIAEKGFPISVYNRTTSKVDETVERAKKEgnlPLYGFKDPEDFVLSIQKPRSVIILVKAGA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  78 PTDNMINTLLPLLDDDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDA 157
Cdd:PLN02350  85 PVDQTIKALSEYMEPGDCIIDGGNEWYENTERRIKEAAEKGLLYLGMGVSGGEEGARNGPSLMPGGSFEAYKNIEDILEK 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 158 ISAKAQDGAsCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKDLLGMSHTEISQTFKDWNAGELESYLIEITGDI 237
Cdd:PLN02350 165 VAAQVDDGP-CVTYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSVGGLSNEELAEVFAEWNKGELESFLIEITADI 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 238 FTELDENNE-PLVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKSLNGP------QASFD 310
Cdd:PLN02350 244 FSVKDDKGDgYLVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSGLKEERVAAAKVFKEAgledilSADSG 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 311 GNKEEFLEKIRKALYMSKICSYAQGFAQMRKASEDHEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDP 390
Cdd:PLN02350 324 VDKKQLIDDVRQALYASKICSYAQGMNLIRAKSVEKGWNLNLGELARIWKGGCIIRAVFLDRIKKAYDRNPDLASLLVDP 403

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446019740 391 YFKNIVTDYQEALRDVVATGVKNGVPTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDHEGVFHTQWDE 467
Cdd:PLN02350 404 EFAKEMVERQAAWRRVVSLAINAGISTPGMSASLAYFDTYRRARLPANLVQAQRDYFGAHTYERVDRPGSFHTEWTK 480
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 178-465 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 570.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  178 GHYVKMVHNGIEYADMQLIAESYAMMKDLLGMSHTEISQTFKDWNAGELESYLIEITGDIFTELDENN-EPLVEKILDTA 256
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEDgKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  257 GQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKSLNGP-QASFDGNKEEFLEKIRKALYMSKICSYAQG 335
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPpPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  336 FAQMRKASEDHEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDPYFKNIVTDYQEALRDVVATGVKNGV 415
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 446019740  416 PTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDHEGVFHTQW 465
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
5-289 8.51e-71

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 226.51  E-value: 8.51e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740   5 IGILGLGVMGKNLAWNIEDKKYSVSIHSRDNneinDTIQKSHYQKIYPAYNLKEFVDSLEKPRKILLMIKAGSPTDNMIN 84
Cdd:COG1023    3 IGMIGLGKMGGNMARRLLRHGHEVVGYDRNP----EAVAALAAEGATGADSLEELVAKLPAPRVVWLMVPAGEITDQVIE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  85 TLLPLLDDDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAISAKAQD 164
Cdd:COG1023   79 ELAPLLEPGDIVIDGGNSNYKDDIRRAEELAEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALAPGAEN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 165 GasCVtYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMK------DLlgmshteiSQTFKDWNAGE-LESYLIEITGDI 237
Cdd:COG1023  159 G--YL-HCGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEasefdlDL--------AEVAEVWRRGSvIRSWLLDLTADA 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446019740 238 FTEldennEPLVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFIS 289
Cdd:COG1023  228 LAE-----DPKLEGISGYVEDSGEGRWTVEEAIELGVPAPVITAALFARFRS 274
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
5-289 1.88e-69

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 223.09  E-value: 1.88e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740   5 IGILGLGVMGKNLAWNIEDKKYSVSIHSRdNNEINDTIQKshyQKIYPAYNLKEFVDSLEKPRKILLMIKAGSPTDNMIN 84
Cdd:PRK09599   3 LGMIGLGRMGGNMARRLLRGGHEVVGYDR-NPEAVEALAE---EGATGADSLEELVAKLPAPRVVWLMVPAGEITDATID 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  85 TLLPLLDDDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAISAKAQD 164
Cdd:PRK09599  79 ELAPLLSPGDIVIDGGNSYYKDDIRRAELLAEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRAED 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 165 GascVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMK----DLlgmshtEISQTFKDWNAGE-LESYLIEITGDIFT 239
Cdd:PRK09599 159 G---YLHAGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEasrfDL------DLAAVAEVWRRGSvIRSWLLDLTADALA 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 446019740 240 EldennEPLVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFIS 289
Cdd:PRK09599 230 E-----DPKLDEISGYVEDSGEGRWTVEEAIDLAVPAPVIAAALFMRFRS 274
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 4-173 7.18e-44

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 151.47  E-value: 7.18e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740    4 NIGILGLGVMGKNLAWNIEDKKYSVSIHSRDNNEINDTIQKShyqkIYPAYNLKEFVDSLekpRKILLMIKAGSPTDNMI 83
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAG----AIAAASPAEFVAGL---DVVITMVPAGAAVDAVI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740   84 NTLLPLLDDDDILI--DGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGP-SLMPGGQEAAYNKVSDILDAISA 160
Cdd:pfam03446  74 FGEGLLPGLKPGDIiiDGSTSSPEDARRRAKELKEKGLHFLDAPVSGGEAGAENGTlSIMVGGDEEAFERVKPILEAMGA 153

                         170
                  ....*....|...
gi 446019740  161 kaqdgasCVTYIG 173
Cdd:pfam03446 154 -------CVTYIG 159
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 5-315 5.88e-43

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 153.46  E-value: 5.88e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740    5 IGILGLGVMGKNLAWNIEDKKYSVSIHSRDNneinDTIQKSHYQKIYPAYNLKEFVDSLEKPRKILLMIKAGSpTDNMIN 84
Cdd:TIGR00872   3 LGLIGLGRMGANIVRRLAKRGHDCVGYDHDQ----DAVKAMKEDRTTGVANLRELSQRLSAPRVVWVMVPHGI-VDAVLE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740   85 TLLPLLDDDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAISAKAQD 164
Cdd:TIGR00872  78 ELAPTLEKGDIVIDGGNSYYKDSLRRYKLLKEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPEEQG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  165 GAscvtYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKDllGMSHTEISQTFKDWNAGE-LESYLIEITGDIFTElde 243
Cdd:TIGR00872 158 YL----YCGPCGSGHFVKMVHNGIEYGMMAAIAEGFEILRN--SQFDFDIPEVARVWRRGSvIRSWLLDLTAIAFRE--- 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446019740  244 nnEPLVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNasKSLNGPQASFDGNKEE 315
Cdd:TIGR00872 229 --SPDLAEFSGRVSDSGEGRWTVIAAIDLGVPAPVIATSLQSRFASRDLDDFAN--KVLAALRKEFGGHAEK 296
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 105-224 6.09e-15

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 75.15  E-value: 6.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 105 QDTIRRNKALAESGVNFIGMGVSGGEVGALTGP-SLMPGGQEAAYNKVSDILDAISAKaqdgascVTYIGPNGAGHYVKM 183
Cdd:COG2084  100 ETARELAAAAAARGVRYLDAPVSGGPAGAEAGTlTIMVGGDEAAFERARPVLEAMGKR-------IVHVGDAGAGQAAKL 172

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446019740 184 VHNGIEYADMQLIAESYAMMKDlLGMSHTEISQTFKDWNAG 224
Cdd:COG2084  173 ANNLLLAGTMAALAEALALAEK-AGLDPETLLEVLSGGAAG 212
garR PRK11559
tartronate semialdehyde reductase; Provisional
 112-183 1.86e-08

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 55.44  E-value: 1.86e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446019740 112 KALAESGVNFIGMGVSGGEVGALTGP-SLMPGGQEAAYNKVSDILDAIsakaqdgASCVTYIGPNGAGHYVKM 183
Cdd:PRK11559 108 AALKAKGIEMLDAPVSGGEPKAIDGTlSVMVGGDKAIFDKYYDLMKAM-------AGSVVHTGDIGAGNVTKL 173
PRK15059 PRK15059
2-hydroxy-3-oxopropionate reductase;
5-284 7.23e-07

2-hydroxy-3-oxopropionate reductase;


Pssm-ID: 185019 [Multi-domain]  Cd Length: 292  Bit Score: 50.79  E-value: 7.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740   5 IGILGLGVMGKNLAWNIedKKYSVSIHSRDNNEINDTIQKSHYQKIYPAYNLKEFVDSlekprkILLMIKAGSPTDNMI- 83
Cdd:PRK15059   3 LGFIGLGIMGTPMAINL--ARAGHQLHVTTIGPVADELLSLGAVSVETARQVTEASDI------IFIMVPDTPQVEEVLf 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740  84 --NTLLPLLDDDDILIDGGNTNYQDTIRRNKALAESGVNFIGMGVSGGEVGALTGP-SLMPGGQEAAYNKVSDILDAISA 160
Cdd:PRK15059  75 geNGCTKASLKGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTlSIMVGGDEAVFERVKPLFELLGK 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446019740 161 KaqdgascVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYaMMKDLLGMSHTEISQTFKdwnAGELESYLIEITGDIFte 240
Cdd:PRK15059 155 N-------ITLVGGNGDGQTCKVANQIIVALNIEAVSEAL-LFASKAGADPVRVRQALM---GGFASSRILEVHGERM-- 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 446019740 241 LDENNEP-----LVEKILDTAGQkgtgkwtSINALELGIPLTIITESVF 284
Cdd:PRK15059 222 IKRTFNPgfkiaLHQKDLNLALQ-------SAKALALNLPNTATCQELF 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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