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Conserved domains on  [gi|446025209|ref|WP_000103064|]
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MULTISPECIES: anti-anti-sigma factor GigB [Gammaproteobacteria]

Protein Classification

STAS domain-containing protein( domain architecture ID 10162419)

STAS (Sulphate Transporter and AntiSigma factor antagonist) domain-containing protein similar to Streptomyces coelicolor anti-sigma-B factor antagonist, a positive regulator of sigma-B activity

CATH:  3.30.750.24
Gene Ontology:  GO:0043856|GO:0006355
PubMed:  22116355|10662676
SCOP:  4003567

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 6-104 3.62e-11

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


:

Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 56.76  E-value: 3.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446025209   6 VEYASLNGTHIFKLIGEVRAHSCISL-DKLLNRIEQQENVVgaIVDLTQTTFIDSTVLGILAKLgLKLKQTHHIQAVMLS 84
Cdd:cd07043    1 ITVEERGGVLVVRLSGELDAATAPELrEALEELLAEGPRRL--VLDLSGVTFIDSSGLGVLLGA-YKRARAAGGRLVLVN 77

                         90       100
                 ....*....|....*....|
gi 446025209  85 TNPDITTLANSMGLGQVFVI 104
Cdd:cd07043   78 VSPAVRRVLELTGLDRLFPI 97
 
Name Accession Description Interval E-value
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 6-104 3.62e-11

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 56.76  E-value: 3.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446025209   6 VEYASLNGTHIFKLIGEVRAHSCISL-DKLLNRIEQQENVVgaIVDLTQTTFIDSTVLGILAKLgLKLKQTHHIQAVMLS 84
Cdd:cd07043    1 ITVEERGGVLVVRLSGELDAATAPELrEALEELLAEGPRRL--VLDLSGVTFIDSSGLGVLLGA-YKRARAAGGRLVLVN 77

                         90       100
                 ....*....|....*....|
gi 446025209  85 TNPDITTLANSMGLGQVFVI 104
Cdd:cd07043   78 VSPAVRRVLELTGLDRLFPI 97
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 12-98 8.57e-08

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 47.54  E-value: 8.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446025209  12 NGTHIFKLIGEVRAHSCISL-DKLLNRIEQQENVVgaIVDLTQTTFIDSTVLGILAKLgLKLKQTHHIQAVMLSTNPDIT 90
Cdd:COG1366    8 DGVLVLPLIGELDAARAPELrEALLEALETGARRV--VLDLSGVTFIDSSGLGALLSL-AKAARLLGGRLVLVGVSPAVA 84


                 ....*...
gi 446025209  91 TLANSMGL 98
Cdd:COG1366   85 RVLELTGL 92
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 12-104 4.59e-05

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 40.68  E-value: 4.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446025209   12 NGTHIFKLIGEVRAHSCISLDKLLNRIEQQENVVGAIVDLTQTTFIDSTVLGILAKLGLKLKQtHHIQAVMLSTNPDITT 91
Cdd:pfam01740   8 PGILILRLDGPLDFANAESLRERLLRALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRR-RGVELVLVGPSPEVAR 86

                          90
                  ....*....|...
gi 446025209   92 LANSMGLGQVFVI 104
Cdd:pfam01740  87 TLEKTGLDDIIKI 99
 
Name Accession Description Interval E-value
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 6-104 3.62e-11

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 56.76  E-value: 3.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446025209   6 VEYASLNGTHIFKLIGEVRAHSCISL-DKLLNRIEQQENVVgaIVDLTQTTFIDSTVLGILAKLgLKLKQTHHIQAVMLS 84
Cdd:cd07043    1 ITVEERGGVLVVRLSGELDAATAPELrEALEELLAEGPRRL--VLDLSGVTFIDSSGLGVLLGA-YKRARAAGGRLVLVN 77

                         90       100
                 ....*....|....*....|
gi 446025209  85 TNPDITTLANSMGLGQVFVI 104
Cdd:cd07043   78 VSPAVRRVLELTGLDRLFPI 97
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 12-98 8.57e-08

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 47.54  E-value: 8.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446025209  12 NGTHIFKLIGEVRAHSCISL-DKLLNRIEQQENVVgaIVDLTQTTFIDSTVLGILAKLgLKLKQTHHIQAVMLSTNPDIT 90
Cdd:COG1366    8 DGVLVLPLIGELDAARAPELrEALLEALETGARRV--VLDLSGVTFIDSSGLGALLSL-AKAARLLGGRLVLVGVSPAVA 84


                 ....*...
gi 446025209  91 TLANSMGL 98
Cdd:COG1366   85 RVLELTGL 92
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 12-104 4.59e-05

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 40.68  E-value: 4.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446025209   12 NGTHIFKLIGEVRAHSCISLDKLLNRIEQQENVVGAIVDLTQTTFIDSTVLGILAKLGLKLKQtHHIQAVMLSTNPDITT 91
Cdd:pfam01740   8 PGILILRLDGPLDFANAESLRERLLRALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRR-RGVELVLVGPSPEVAR 86

                          90
                  ....*....|...
gi 446025209   92 LANSMGLGQVFVI 104
Cdd:pfam01740  87 TLEKTGLDDIIKI 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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