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LexA family transcriptional regulator [Escherichia coli]

Protein Classification

LexA family protein( domain architecture ID 11449429)

LexA family protein may function as a transcriptional regulator involved in the repression of one or more genes involved in the response to DNA damage (SOS response), including recA and lexA and/or may contain a S24 peptidase domain such as in the translesion error-prone DNA polymerase V autoproteolytic subunit

Gene Ontology:  GO:0003677|GO:0045892
PubMed:  10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 19-236 1.35e-22

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 91.13  E-value: 1.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737  19 ISERIRNRRKDVGL--TQEQVAKAIGITRVSVTKWENG-SSKPdgenlhllskllskspeWILYGKDDHDKIDVLRlnqh 95
Cdd:COG1974   11 ILDFIKEYIRERGYppSQREIAEALGLSSSAVHRHLKAlEKKG-----------------YLRRDPGKSRAIELLP---- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737  96 lyISDNIARLPVLTWEQAGYwdmscPVTEIPGIKNWVDV---MTKTAENSFLLHVEGDSMTNsnglPTIPDGSTVLITPc 172
Cdd:COG1974   70 --ASPEVVGLPLLGRVAAGF-----PIPAEENIEEYLDLpeeLVKNPGATFALRVKGDSMID----AGILDGDLVIVDR- 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446026737 173 SSNIRElvGKIILIQLEGtpNVTLKKVAIDGPNIYLLSLNPLYKPIELNVG-YTIKGKV-SQIHQY 236
Cdd:COG1974  138 QLEAEN--GDIVVALIDG--EATVKRLYKEGGRVRLQPENPAYPPIIIEGDdVEILGVVvGVIRRL 199
 
Name Accession Description Interval E-value
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 19-236 1.35e-22

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 91.13  E-value: 1.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737  19 ISERIRNRRKDVGL--TQEQVAKAIGITRVSVTKWENG-SSKPdgenlhllskllskspeWILYGKDDHDKIDVLRlnqh 95
Cdd:COG1974   11 ILDFIKEYIRERGYppSQREIAEALGLSSSAVHRHLKAlEKKG-----------------YLRRDPGKSRAIELLP---- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737  96 lyISDNIARLPVLTWEQAGYwdmscPVTEIPGIKNWVDV---MTKTAENSFLLHVEGDSMTNsnglPTIPDGSTVLITPc 172
Cdd:COG1974   70 --ASPEVVGLPLLGRVAAGF-----PIPAEENIEEYLDLpeeLVKNPGATFALRVKGDSMID----AGILDGDLVIVDR- 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446026737 173 SSNIRElvGKIILIQLEGtpNVTLKKVAIDGPNIYLLSLNPLYKPIELNVG-YTIKGKV-SQIHQY 236
Cdd:COG1974  138 QLEAEN--GDIVVALIDG--EATVKRLYKEGGRVRLQPENPAYPPIIIEGDdVEILGVVvGVIRRL 199
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 15-105 1.06e-20

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 84.52  E-value: 1.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737  15 MKN-TISERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKPDGENLHLLSKLLSKSPEWILYGKDDHDKIDVLRLN 93
Cdd:PRK09706   1 MKNlTLGQRIRYRRKQLKLSQRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCSPTWLLFGDEDKQPTPPVPLN 80

                         90
                 ....*....|..
gi 446026737  94 QHLYISDNIARL 105
Cdd:PRK09706  81 QPVELSEDQKEL 92
Peptidase_S24 pfam00717
Peptidase S24-like;
106-230 7.50e-20

Peptidase S24-like;


Pssm-ID: 425835  Cd Length: 116  Bit Score: 81.48  E-value: 7.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737  106 PVLTWEQAGYWdmSCPVTEIPGIKNWVDVMTKTAENSFLLHVEGDSMTnsnglPTIPDGSTVLITPcSSNIRelVGKIIL 185
Cdd:pfam00717   1 PLIGRVAAGAP--ILAEEEIEGYLPLPESLLSPPGNLFALRVKGDSME-----PGIPDGDLVLVDP-SREAR--NGDIVV 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 446026737  186 IQLEGtpNVTLKKVAIDGPNIYLLSLNPLYKPIELNVGY--TIKGKV 230
Cdd:pfam00717  71 ARLDG--EATVKRLYRDGGGIRLISLNPEYPPIELPAEDdvEIIGRV 115
S24_LexA-like cd06529
Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of ...
 143-221 1.83e-13

Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response.


Pssm-ID: 119397 [Multi-domain]  Cd Length: 81  Bit Score: 63.73  E-value: 1.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737 143 FLLHVEGDSMTnsnglPTIPDGSTVLITPcssNIRELVGKIILIQLEGTpnVTLKKVAIDGPN-IYLLSLNPLYKPIELN 221
Cdd:cd06529    1 FALRVKGDSME-----PTIPDGDLVLVDP---SDTPRDGDIVVARLDGE--LTVKRLQRRGGGrLRLISDNPAYPPIEID 70
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
22-62 8.22e-11

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 55.99  E-value: 8.22e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 446026737    22 RIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKPDGEN 62
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLET 41
CxxCG_CxxCG_HTH TIGR03830
putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of ...
 19-58 1.08e-06

putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation.


Pssm-ID: 274805 [Multi-domain]  Cd Length: 127  Bit Score: 46.47  E-value: 1.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 446026737   19 ISERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKP 58
Cdd:TIGR03830  66 TGPEIRRIRKKLGLSQREAAELLGGGVNAFSRYERGEVRP 105
 
Name Accession Description Interval E-value
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 19-236 1.35e-22

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 91.13  E-value: 1.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737  19 ISERIRNRRKDVGL--TQEQVAKAIGITRVSVTKWENG-SSKPdgenlhllskllskspeWILYGKDDHDKIDVLRlnqh 95
Cdd:COG1974   11 ILDFIKEYIRERGYppSQREIAEALGLSSSAVHRHLKAlEKKG-----------------YLRRDPGKSRAIELLP---- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737  96 lyISDNIARLPVLTWEQAGYwdmscPVTEIPGIKNWVDV---MTKTAENSFLLHVEGDSMTNsnglPTIPDGSTVLITPc 172
Cdd:COG1974   70 --ASPEVVGLPLLGRVAAGF-----PIPAEENIEEYLDLpeeLVKNPGATFALRVKGDSMID----AGILDGDLVIVDR- 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446026737 173 SSNIRElvGKIILIQLEGtpNVTLKKVAIDGPNIYLLSLNPLYKPIELNVG-YTIKGKV-SQIHQY 236
Cdd:COG1974  138 QLEAEN--GDIVVALIDG--EATVKRLYKEGGRVRLQPENPAYPPIIIEGDdVEILGVVvGVIRRL 199
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 15-105 1.06e-20

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 84.52  E-value: 1.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737  15 MKN-TISERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKPDGENLHLLSKLLSKSPEWILYGKDDHDKIDVLRLN 93
Cdd:PRK09706   1 MKNlTLGQRIRYRRKQLKLSQRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCSPTWLLFGDEDKQPTPPVPLN 80

                         90
                 ....*....|..
gi 446026737  94 QHLYISDNIARL 105
Cdd:PRK09706  81 QPVELSEDQKEL 92
Peptidase_S24 pfam00717
Peptidase S24-like;
106-230 7.50e-20

Peptidase S24-like;


Pssm-ID: 425835  Cd Length: 116  Bit Score: 81.48  E-value: 7.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737  106 PVLTWEQAGYWdmSCPVTEIPGIKNWVDVMTKTAENSFLLHVEGDSMTnsnglPTIPDGSTVLITPcSSNIRelVGKIIL 185
Cdd:pfam00717   1 PLIGRVAAGAP--ILAEEEIEGYLPLPESLLSPPGNLFALRVKGDSME-----PGIPDGDLVLVDP-SREAR--NGDIVV 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 446026737  186 IQLEGtpNVTLKKVAIDGPNIYLLSLNPLYKPIELNVGY--TIKGKV 230
Cdd:pfam00717  71 ARLDG--EATVKRLYRDGGGIRLISLNPEYPPIELPAEDdvEIIGRV 115
COG2932 COG2932
Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: ...
 139-230 2.65e-14

Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: prophages, transposons];


Pssm-ID: 442176  Cd Length: 121  Bit Score: 66.91  E-value: 2.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737 139 AENSFLLHVEGDSMtnsngLPTIPDGSTVLITPCSSNIRElvGKIILIQLEGtpNVTLKKVAIDGPN-IYLLSLNPLYKP 217
Cdd:COG2932   32 PDNLFAVRVSGDSM-----EPTIRDGDIVLVDPSDTEIRD--GGIYVVRTDG--ELLVKRLQRRPDGkLRLISDNPAYPP 102

                         90
                 ....*....|....*..
gi 446026737 218 IELNVG----YTIKGKV 230
Cdd:COG2932  103 IEIPPEdadeIEIIGRV 119
S24_LexA-like cd06529
Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of ...
 143-221 1.83e-13

Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response.


Pssm-ID: 119397 [Multi-domain]  Cd Length: 81  Bit Score: 63.73  E-value: 1.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737 143 FLLHVEGDSMTnsnglPTIPDGSTVLITPcssNIRELVGKIILIQLEGTpnVTLKKVAIDGPN-IYLLSLNPLYKPIELN 221
Cdd:cd06529    1 FALRVKGDSME-----PTIPDGDLVLVDP---SDTPRDGDIVVARLDGE--LTVKRLQRRGGGrLRLISDNPAYPPIEID 70
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
15-59 7.30e-13

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 61.79  E-value: 7.30e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 446026737  15 MKNTISERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKPD 59
Cdd:COG1476    1 MKKKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPS 45
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
15-59 2.02e-12

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 60.78  E-value: 2.02e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 446026737  15 MKNTISERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKPD 59
Cdd:COG1396    4 LKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPS 48
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 20-62 4.40e-11

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 56.79  E-value: 4.40e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 446026737  20 SERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKPDGEN 62
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLET 43
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
22-62 8.22e-11

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 55.99  E-value: 8.22e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 446026737    22 RIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKPDGEN 62
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLET 41
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 23-62 1.45e-10

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 55.24  E-value: 1.45e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 446026737   23 IRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKPDGEN 62
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLET 40
Peptidase_S24_S26 cd06462
The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal ...
 143-230 1.86e-10

The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The S26 type I signal peptidase (SPase) family also includes mitochondrial inner membrane protease (IMP)-like members. SPases are essential membrane-bound proteases which function to cleave away the amino-terminal signal peptide from the translocated pre-protein, thus playing a crucial role in the transport of proteins across membranes in all living organisms. All members in this superfamily are unique serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases.


Pssm-ID: 119396 [Multi-domain]  Cd Length: 84  Bit Score: 55.73  E-value: 1.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737 143 FLLHVEGDSMTnsnglPTIPDGSTVLITPCSSNIRelVGKIILIQLEGtPNVTLKKVAIDGPN--IYLLSLNPLYKPIEL 220
Cdd:cd06462    1 FALRVEGDSME-----PTIPDGDLVLVDKSSYEPK--RGDIVVFRLPG-GELTVKRVIGLPGEghYFLLGDNPNSPDSRI 72

                         90
                 ....*....|..
gi 446026737 221 NVGY--TIKGKV 230
Cdd:cd06462   73 DGPPelDIVGVV 84
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 18-61 4.06e-09

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 51.48  E-value: 4.06e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 446026737  18 TISERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKPDGE 61
Cdd:COG1813   12 DYGERIREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLD 55
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 21-83 2.03e-08

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 49.59  E-value: 2.03e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446026737   21 ERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKPDGENLHLLSKLLSKSPEWILYGKDD 83
Cdd:pfam12844   2 ERLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLYKIAELLGVPANWLLQGEGE 64
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
21-60 4.48e-08

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 48.78  E-value: 4.48e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 446026737  21 ERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKPDG 60
Cdd:COG2944    9 EEIRALRERLGLSQAEFAALLGVSVSTVRRWEQGRRKPSG 48
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 17-58 1.74e-07

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 47.71  E-value: 1.74e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 446026737  17 NTISERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKP 58
Cdd:COG3620   16 DTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDP 57
CxxCG_CxxCG_HTH TIGR03830
putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of ...
 19-58 1.08e-06

putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation.


Pssm-ID: 274805 [Multi-domain]  Cd Length: 127  Bit Score: 46.47  E-value: 1.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 446026737   19 ISERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENGSSKP 58
Cdd:TIGR03830  66 TGPEIRRIRKKLGLSQREAAELLGGGVNAFSRYERGEVRP 105
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 21-54 1.43e-06

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 44.44  E-value: 1.43e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 446026737   21 ERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENG 54
Cdd:pfam13560   4 ARLRRLRERAGLSQEALARRLGVSRSTLSRLETG 37
couple_hipB TIGR03070
transcriptional regulator, y4mF family; Members of this family belong to a clade of ...
 19-54 3.34e-05

transcriptional regulator, y4mF family; Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions]


Pssm-ID: 213767 [Multi-domain]  Cd Length: 58  Bit Score: 40.34  E-value: 3.34e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 446026737   19 ISERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENG 54
Cdd:TIGR03070   3 IGILVRARRKALGLTQADLADLAGVGLRFIRDLENG 38
lexA TIGR00498
SOS regulatory protein LexA; LexA acts as a homodimer to repress a number of genes involved in ...
 135-230 1.21e-04

SOS regulatory protein LexA; LexA acts as a homodimer to repress a number of genes involved in the response to DNA damage (SOS response), including itself and RecA. RecA, in the presence of single-stranded DNA, acts as a co-protease to activate a latent autolytic protease activity (EC 3.4.21.88) of LexA, where the active site Ser is part of LexA. The autolytic cleavage site is an Ala-Gly bond in LexA (at position 84-85 in E. coli LexA; this sequence is replaced by Gly-Gly in Synechocystis). The cleavage leads to derepression of the SOS regulon and eventually to DNA repair. LexA in Bacillus subtilis is called DinR. LexA is much less broadly distributed than RecA. [DNA metabolism, DNA replication, recombination, and repair, Regulatory functions, DNA interactions]


Pssm-ID: 273106 [Multi-domain]  Cd Length: 199  Bit Score: 41.62  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446026737  135 MTKTAENSFLLHVEGDSMTNSNglptIPDGSTVLITPcSSNIRElvGKIILIQLEGtpNVTLKKVAIDGPNIYLLSLNPL 214
Cdd:TIGR00498 104 LLKKPSAVFLLKVMGDSMVDAG----ICDGDLLIVRS-QKDARN--GEIVAAMIDG--EVTVKRFYKDGTKVELKPENPE 174

                          90
                  ....*....|....*..
gi 446026737  215 YKPIELNV-GYTIKGKV 230
Cdd:TIGR00498 175 FDPIVLNAeDVTILGKV 191
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 18-54 1.36e-04

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 39.02  E-value: 1.36e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 446026737  18 TISERIRNRRKDVGLTQEQVAKAIGITRVSVTKWENG 54
Cdd:COG1426    5 TIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEG 41
DUF3527 pfam12043
Domain of unknown function (DUF3527); This presumed domain is functionally uncharacterized. ...
 114-160 3.19e-04

Domain of unknown function (DUF3527); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 120 amino acids in length. This domain has a conserved CDCGGWD sequence motif.


Pssm-ID: 463443  Cd Length: 350  Bit Score: 41.17  E-value: 3.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 446026737  114 GYWDMSCPVT--EIPGIKNWVDVMTKTAENSFLLHVEGdsmtNSNGLPT 160
Cdd:pfam12043 271 GGWDMGCPLTvlNNPSINSLSDASTEEDCKSFELFVQG----SKEKEPA 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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