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Conserved domains on  [gi|446027864|ref|WP_000105719|]
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MULTISPECIES: sulfurtransferase complex subunit TusD [Acinetobacter]

Protein Classification

sulfur relay protein TusD/DsrE( domain architecture ID 10021637)

sulfurtransferase TusD/DsrE is part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions; it accepts sulfur from TusA and transfers it in turn to TusE

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
sulf_tusD_dsrE TIGR03012
sulfur relay protein TusD/DsrE; The three proteins TusB, TusC, and TusD form a heterohexamer ...
 1-122 1.40e-48

sulfur relay protein TusD/DsrE; The three proteins TusB, TusC, and TusD form a heterohexamer responsible for a sulfur relay reaction. In large numbers of proteobacterial species, this complex acts on a Cys-derived persulfide moiety, delivered by the cysteine desulfurase IscS to TusA, then to TusBCD. The activated sulfur group is then transferred to TusE (DsrC), then by MnmA (TrmU) for modification of an anticodon nucleotide in tRNAs for Glu, Lys, and Gln. The sulfur relay complex TusBCD is also found, under the designation DsrEFH, in phototrophic and chemotrophic sulfur bacteria, such as Chromatium vinosum. In these organisms, it seems the primary purpose is related to sulfur flux, such as oxidation from sulfide to molecular sulfur to sulfate. [Protein synthesis, tRNA and rRNA base modification]


:

Pssm-ID: 274389  Cd Length: 127  Bit Score: 151.25  E-value: 1.40e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446027864    1 MSTLLLITSAPTSIHAWHALGLAQA-LKSKNEDFRVFFYQDGVQVANDFQWVPDDQRNLTHEWQKLS----IRLPVCVSA 75
Cdd:TIGR03012   1 KYTLLVTGPPYGTQAASSAYQFAQAlLAKGHEISRVFFYQDGVLNANNLVSPASDEFDLVAAWQQLAqehqVDLVVCVAA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 446027864   76 ALARGITDAENASRHQLSHHNLANNFELVGLGELADAVQSASRLLQF 122
Cdd:TIGR03012  81 ALRRGVVDEEEASRLQISHGNLAPGFELSGLGELAEAALTADRLVQF 127
 
Name Accession Description Interval E-value
sulf_tusD_dsrE TIGR03012
sulfur relay protein TusD/DsrE; The three proteins TusB, TusC, and TusD form a heterohexamer ...
 1-122 1.40e-48

sulfur relay protein TusD/DsrE; The three proteins TusB, TusC, and TusD form a heterohexamer responsible for a sulfur relay reaction. In large numbers of proteobacterial species, this complex acts on a Cys-derived persulfide moiety, delivered by the cysteine desulfurase IscS to TusA, then to TusBCD. The activated sulfur group is then transferred to TusE (DsrC), then by MnmA (TrmU) for modification of an anticodon nucleotide in tRNAs for Glu, Lys, and Gln. The sulfur relay complex TusBCD is also found, under the designation DsrEFH, in phototrophic and chemotrophic sulfur bacteria, such as Chromatium vinosum. In these organisms, it seems the primary purpose is related to sulfur flux, such as oxidation from sulfide to molecular sulfur to sulfate. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 274389  Cd Length: 127  Bit Score: 151.25  E-value: 1.40e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446027864    1 MSTLLLITSAPTSIHAWHALGLAQA-LKSKNEDFRVFFYQDGVQVANDFQWVPDDQRNLTHEWQKLS----IRLPVCVSA 75
Cdd:TIGR03012   1 KYTLLVTGPPYGTQAASSAYQFAQAlLAKGHEISRVFFYQDGVLNANNLVSPASDEFDLVAAWQQLAqehqVDLVVCVAA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 446027864   76 ALARGITDAENASRHQLSHHNLANNFELVGLGELADAVQSASRLLQF 122
Cdd:TIGR03012  81 ALRRGVVDEEEASRLQISHGNLAPGFELSGLGELAEAALTADRLVQF 127
DsrE COG1553
Sulfur relay (sulfurtransferase) complex TusBCD TusD component, DsrE family [Inorganic ion ...
 1-122 2.65e-37

Sulfur relay (sulfurtransferase) complex TusBCD TusD component, DsrE family [Inorganic ion transport and metabolism];


Pssm-ID: 441162  Cd Length: 118  Bit Score: 122.59  E-value: 2.65e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446027864   1 MSTLLLITSAP-TSIHAWHALGLAQALKSKNED-FRVFFYQDGVQVANDFQWVPDDQRNLTHEWQKLS----IRLPVCVS 74
Cdd:COG1553    1 MKYLLIVNGPPyGSQAAYSALRFAEALLEKGHEvDRVFFYQDGVLNANALQKPPSDEYNLVQMWQELAaqhgVELVVCGA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446027864  75 AALARGITDAEnasrhqlshhNLANNFELVGLGELADAVQSASRLLQF 122
Cdd:COG1553   81 CALRRGITDEE----------NLIEGFELSGLGELAEATLEADRVITF 118
PRK00207 PRK00207
sulfurtransferase complex subunit TusD;
1-122 1.89e-35

sulfurtransferase complex subunit TusD;


Pssm-ID: 178928  Cd Length: 128  Bit Score: 118.04  E-value: 1.89e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446027864   1 MSTLLLITSAP-TSIHAWHALGLAQA-LKSKNEDFRVFFYQDGVQVANDFQWVPDDQRNLTHEWQKLS----IRLPVCVS 74
Cdd:PRK00207   1 MRYAIAVTGPAyGTQQASSAYQFAQAlLAEGHELVSVFFYQDGVLNANALTVPASDEFDLVRAWQQLAaehgVALNVCVA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446027864  75 AALARGITDAENASRHQLSHHNLANNFELVGLGELADAVQSASRLLQF 122
Cdd:PRK00207  81 AALRRGVVDEEEAERLGLAAANLAPGFELSGLGELAEASLTADRVVQF 128
DrsE pfam02635
DsrE/DsrF-like family; DsrE is a small soluble protein involved in intracellular sulfur ...
 1-122 1.86e-20

DsrE/DsrF-like family; DsrE is a small soluble protein involved in intracellular sulfur reduction. This family also includes DsrF.


Pssm-ID: 426894  Cd Length: 117  Bit Score: 79.69  E-value: 1.86e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446027864    1 MSTLLLITSAP-TSIHAWHALGLAQALKSKNEDFRVFFYQDGVQVANDFQWV-PDDQRNLTHEWQKLS---IRLPVCVSA 75
Cdd:pfam02635   1 KKVFIVVTSGPyGTEAAREALDLALAAAALGHDVAVFFHGDGVLNLLKGQEPnPIGEKNLAELLKALAeygVKVYVCGQS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 446027864   76 ALARGITDAEnasrhqlshhNLANNFELVGLGELADAVQSASRLLQF 122
Cdd:pfam02635  81 LKARGITEDE----------LLGVGVEVSGLGELAELQLEGDRVITF 117
 
Name Accession Description Interval E-value
sulf_tusD_dsrE TIGR03012
sulfur relay protein TusD/DsrE; The three proteins TusB, TusC, and TusD form a heterohexamer ...
 1-122 1.40e-48

sulfur relay protein TusD/DsrE; The three proteins TusB, TusC, and TusD form a heterohexamer responsible for a sulfur relay reaction. In large numbers of proteobacterial species, this complex acts on a Cys-derived persulfide moiety, delivered by the cysteine desulfurase IscS to TusA, then to TusBCD. The activated sulfur group is then transferred to TusE (DsrC), then by MnmA (TrmU) for modification of an anticodon nucleotide in tRNAs for Glu, Lys, and Gln. The sulfur relay complex TusBCD is also found, under the designation DsrEFH, in phototrophic and chemotrophic sulfur bacteria, such as Chromatium vinosum. In these organisms, it seems the primary purpose is related to sulfur flux, such as oxidation from sulfide to molecular sulfur to sulfate. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 274389  Cd Length: 127  Bit Score: 151.25  E-value: 1.40e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446027864    1 MSTLLLITSAPTSIHAWHALGLAQA-LKSKNEDFRVFFYQDGVQVANDFQWVPDDQRNLTHEWQKLS----IRLPVCVSA 75
Cdd:TIGR03012   1 KYTLLVTGPPYGTQAASSAYQFAQAlLAKGHEISRVFFYQDGVLNANNLVSPASDEFDLVAAWQQLAqehqVDLVVCVAA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 446027864   76 ALARGITDAENASRHQLSHHNLANNFELVGLGELADAVQSASRLLQF 122
Cdd:TIGR03012  81 ALRRGVVDEEEASRLQISHGNLAPGFELSGLGELAEAALTADRLVQF 127
DsrE COG1553
Sulfur relay (sulfurtransferase) complex TusBCD TusD component, DsrE family [Inorganic ion ...
 1-122 2.65e-37

Sulfur relay (sulfurtransferase) complex TusBCD TusD component, DsrE family [Inorganic ion transport and metabolism];


Pssm-ID: 441162  Cd Length: 118  Bit Score: 122.59  E-value: 2.65e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446027864   1 MSTLLLITSAP-TSIHAWHALGLAQALKSKNED-FRVFFYQDGVQVANDFQWVPDDQRNLTHEWQKLS----IRLPVCVS 74
Cdd:COG1553    1 MKYLLIVNGPPyGSQAAYSALRFAEALLEKGHEvDRVFFYQDGVLNANALQKPPSDEYNLVQMWQELAaqhgVELVVCGA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446027864  75 AALARGITDAEnasrhqlshhNLANNFELVGLGELADAVQSASRLLQF 122
Cdd:COG1553   81 CALRRGITDEE----------NLIEGFELSGLGELAEATLEADRVITF 118
PRK00207 PRK00207
sulfurtransferase complex subunit TusD;
1-122 1.89e-35

sulfurtransferase complex subunit TusD;


Pssm-ID: 178928  Cd Length: 128  Bit Score: 118.04  E-value: 1.89e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446027864   1 MSTLLLITSAP-TSIHAWHALGLAQA-LKSKNEDFRVFFYQDGVQVANDFQWVPDDQRNLTHEWQKLS----IRLPVCVS 74
Cdd:PRK00207   1 MRYAIAVTGPAyGTQQASSAYQFAQAlLAEGHELVSVFFYQDGVLNANALTVPASDEFDLVRAWQQLAaehgVALNVCVA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446027864  75 AALARGITDAENASRHQLSHHNLANNFELVGLGELADAVQSASRLLQF 122
Cdd:PRK00207  81 AALRRGVVDEEEAERLGLAAANLAPGFELSGLGELAEASLTADRVVQF 128
DrsE pfam02635
DsrE/DsrF-like family; DsrE is a small soluble protein involved in intracellular sulfur ...
 1-122 1.86e-20

DsrE/DsrF-like family; DsrE is a small soluble protein involved in intracellular sulfur reduction. This family also includes DsrF.


Pssm-ID: 426894  Cd Length: 117  Bit Score: 79.69  E-value: 1.86e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446027864    1 MSTLLLITSAP-TSIHAWHALGLAQALKSKNEDFRVFFYQDGVQVANDFQWV-PDDQRNLTHEWQKLS---IRLPVCVSA 75
Cdd:pfam02635   1 KKVFIVVTSGPyGTEAAREALDLALAAAALGHDVAVFFHGDGVLNLLKGQEPnPIGEKNLAELLKALAeygVKVYVCGQS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 446027864   76 ALARGITDAEnasrhqlshhNLANNFELVGLGELADAVQSASRLLQF 122
Cdd:pfam02635  81 LKARGITEDE----------LLGVGVEVSGLGELAELQLEGDRVITF 117
COG2044 COG2044
Predicted peroxiredoxin, DsrE/DsrF-like family [General function prediction only];
1-122 1.00e-03

Predicted peroxiredoxin, DsrE/DsrF-like family [General function prediction only];


Pssm-ID: 441647  Cd Length: 121  Bit Score: 36.03  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446027864   1 MSTLLLI--TSAPTSIH-AWHALGLAQALKSKNEDFRVFFYQDGVQVAndfqwVPDDQRNLTH-----------EWQKLS 66
Cdd:COG2044    1 MAEKLVIllTSGPDDPErATMAFVLAAAAAAMGAEVTIFLTGEGVRLA-----KKGVAEKIRApggppladlleEAIEAG 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446027864  67 IRLPVCVSAALARGITDAEnasrhqlshhnLANNFELVGLGELADAV-QSASRLLQF 122
Cdd:COG2044   76 VKVYVCEPCLKARGLTEED-----------LIPGVEIAGAADFAELAlEADARVLTF 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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