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Conserved domains on  [gi|446040665|ref|WP_000118520|]
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MULTISPECIES: quaternary ammonium compound efflux SMR transporter SugE [Gammaproteobacteria]

Protein Classification

DMT family transporter( domain architecture ID 10013801)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11431 PRK11431
quaternary ammonium compound efflux SMR transporter SugE;
1-105 8.20e-44

quaternary ammonium compound efflux SMR transporter SugE;


:

Pssm-ID: 171110  Cd Length: 105  Bit Score: 138.07  E-value: 8.20e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446040665   1 MSWIVLLIAGLLEVVWAIGLKYTHGFTRLTPSIITIAAMIVSIAMLSWAMRTLPVGTAYAVWTGIGAVGAAITGILLLGE 80
Cdd:PRK11431   1 MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSIITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGE 80

                         90       100
                 ....*....|....*....|....*
gi 446040665  81 SASPARLLSLGLIVAGIIGLKLSTH 105
Cdd:PRK11431  81 SASPARLLSLALIVAGIIGLKLSTH 105
 
Name Accession Description Interval E-value
PRK11431 PRK11431
quaternary ammonium compound efflux SMR transporter SugE;
1-105 8.20e-44

quaternary ammonium compound efflux SMR transporter SugE;


Pssm-ID: 171110  Cd Length: 105  Bit Score: 138.07  E-value: 8.20e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446040665   1 MSWIVLLIAGLLEVVWAIGLKYTHGFTRLTPSIITIAAMIVSIAMLSWAMRTLPVGTAYAVWTGIGAVGAAITGILLLGE 80
Cdd:PRK11431   1 MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSIITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGE 80

                         90       100
                 ....*....|....*....|....*
gi 446040665  81 SASPARLLSLGLIVAGIIGLKLSTH 105
Cdd:PRK11431  81 SASPARLLSLALIVAGIIGLKLSTH 105
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
2-105 6.31e-33

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 110.19  E-value: 6.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446040665   2 SWIVLLIAGLLEVVWAIGLKYTHGFTRLTPSIITIAAMIVSIAMLSWAMRTLPVGTAYAVWTGIGAVGAAITGILLLGES 81
Cdd:COG2076    1 AWLYLLLAGLLEVVWTLALKLSDGFTRLLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEP 80

                         90       100
                 ....*....|....*....|....
gi 446040665  82 ASPARLLSLGLIVAGIIGLKLSTH 105
Cdd:COG2076   81 LSLARLLGIALIIAGVVGLKLFSG 104
Multi_Drug_Res pfam00893
Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. ...
 1-93 5.78e-24

Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide and quaternary ammonium compounds, through coupling with proton influx.


Pssm-ID: 459985  Cd Length: 93  Bit Score: 87.34  E-value: 5.78e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446040665    1 MSWIVLLIAGLLEVVWAIGLKYTHGFTRLTPSIITIAAMIVSIAMLSWAMRTLPVGTAYAVWTGIGAVGAAITGILLLGE 80
Cdd:pfam00893   1 MGWILLVLAIVLEVVGTSLLKYSEGFTRLWPSILVIVGYGLSFYLLSLALKSIPLGVAYAVWSGIGTVGTTLVGILLFGE 80

                          90
                  ....*....|...
gi 446040665   81 SASPARLLSLGLI 93
Cdd:pfam00893  81 SLSLKKVIGLGLI 93
 
Name Accession Description Interval E-value
PRK11431 PRK11431
quaternary ammonium compound efflux SMR transporter SugE;
1-105 8.20e-44

quaternary ammonium compound efflux SMR transporter SugE;


Pssm-ID: 171110  Cd Length: 105  Bit Score: 138.07  E-value: 8.20e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446040665   1 MSWIVLLIAGLLEVVWAIGLKYTHGFTRLTPSIITIAAMIVSIAMLSWAMRTLPVGTAYAVWTGIGAVGAAITGILLLGE 80
Cdd:PRK11431   1 MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSIITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGE 80

                         90       100
                 ....*....|....*....|....*
gi 446040665  81 SASPARLLSLGLIVAGIIGLKLSTH 105
Cdd:PRK11431  81 SASPARLLSLALIVAGIIGLKLSTH 105
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
2-105 6.31e-33

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 110.19  E-value: 6.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446040665   2 SWIVLLIAGLLEVVWAIGLKYTHGFTRLTPSIITIAAMIVSIAMLSWAMRTLPVGTAYAVWTGIGAVGAAITGILLLGES 81
Cdd:COG2076    1 AWLYLLLAGLLEVVWTLALKLSDGFTRLLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEP 80

                         90       100
                 ....*....|....*....|....
gi 446040665  82 ASPARLLSLGLIVAGIIGLKLSTH 105
Cdd:COG2076   81 LSLARLLGIALIIAGVVGLKLFSG 104
Multi_Drug_Res pfam00893
Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. ...
 1-93 5.78e-24

Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide and quaternary ammonium compounds, through coupling with proton influx.


Pssm-ID: 459985  Cd Length: 93  Bit Score: 87.34  E-value: 5.78e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446040665    1 MSWIVLLIAGLLEVVWAIGLKYTHGFTRLTPSIITIAAMIVSIAMLSWAMRTLPVGTAYAVWTGIGAVGAAITGILLLGE 80
Cdd:pfam00893   1 MGWILLVLAIVLEVVGTSLLKYSEGFTRLWPSILVIVGYGLSFYLLSLALKSIPLGVAYAVWSGIGTVGTTLVGILLFGE 80

                          90
                  ....*....|...
gi 446040665   81 SASPARLLSLGLI 93
Cdd:pfam00893  81 SLSLKKVIGLGLI 93
emrE PRK09541
EmrE family multidrug efflux SMR transporter;
2-102 4.71e-10

EmrE family multidrug efflux SMR transporter;


Pssm-ID: 137367  Cd Length: 110  Bit Score: 52.28  E-value: 4.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446040665   2 SWIVLLIAGLLEVVWAIGLKYTHGFTRLTPSIITIAAMIVSIAMLSWAMRTLPVGTAYAVWTGIGAVGAAITGILLLGES 81
Cdd:PRK09541   3 PYIYLGGAILAEVIGTTLMKFSEGFTRLWPSVGTIICYCASFWLLAQTLAYIPTGIAYAIWSGVGIVLISLLSWGFFGQR 82

                         90       100
                 ....*....|....*....|.
gi 446040665  82 ASPARLLSLGLIVAGIIGLKL 102
Cdd:PRK09541  83 LDLPAIIGMMLICAGVLVINL 103
PRK10650 PRK10650
multidrug/spermidine efflux SMR transporter subunit MdtI;
6-103 1.96e-07

multidrug/spermidine efflux SMR transporter subunit MdtI;


Pssm-ID: 182618  Cd Length: 109  Bit Score: 45.42  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446040665   6 LLIAGLLEVVWAIGLKYTHGFTRLTPSIITIAAMIVSIAMLSWAMRTLPVGTAYAVWTGIGAVGAAITGILLLGESASPA 85
Cdd:PRK10650  12 LALAIVLEIVANIFLKFSDGFRRKIYGILSLAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAGWILFGQRLNRK 91

                         90
                 ....*....|....*...
gi 446040665  86 RLLSLGLIVAGIIGLKLS 103
Cdd:PRK10650  92 GWIGLVLLLAGMVMIKLA 109
PRK10452 PRK10452
multidrug/spermidine efflux SMR transporter subunit MdtJ;
3-104 6.19e-06

multidrug/spermidine efflux SMR transporter subunit MdtJ;


Pssm-ID: 182471  Cd Length: 120  Bit Score: 41.68  E-value: 6.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446040665   3 WIVLLIAGLLEVVWAIGLKYTHGFTRLTPSIITIAAMIVSIAMLSWAMRTLPVGTAYAVWTGIGAVGAAITGILLLGESA 82
Cdd:PRK10452   4 WILLALAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLFDESL 83

                         90       100
                 ....*....|....*....|..
gi 446040665  83 SPARLLSLGLIVAGIIGLKLST 104
Cdd:PRK10452  84 SLMKIAGLTTLVAGIVLIKSGT 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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