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Conserved domains on  [gi|446044786|ref|WP_000122641|]
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MULTISPECIES: superoxide dismutase [Mn] [Enterobacteriaceae]

Protein Classification

superoxide dismutase( domain architecture ID 11485100)

superoxide dismutase [Mn] eliminates superoxide radicals by catalyzing their conversion into hydrogen peroxide and oxygen

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10925 PRK10925
superoxide dismutase [Mn];
1-206 1.59e-158

superoxide dismutase [Mn];


:

Pssm-ID: 182843  Cd Length: 206  Bit Score: 435.89  E-value: 1.59e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   1 MSYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLDQLPADKKTVLRNNAGGHA 80
Cdd:PRK10925   1 MSYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLDQLPADKKTVLRNNAGGHA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786  81 NHSLFWKGLKKGTTLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGDKLAVVSTANQDSPLMGEAISGAS 160
Cdd:PRK10925  81 NHSLFWKGLKKGTTLQGDLKAAIERDFGSVDNFKAEFEKAAATRFGSGWAWLVLKGDKLAVVSTANQDSPLMGEAISGAS 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446044786 161 GFPIMGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAARFAAKK 206
Cdd:PRK10925 161 GFPILGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAARFAAKK 206
 
Name Accession Description Interval E-value
PRK10925 PRK10925
superoxide dismutase [Mn];
1-206 1.59e-158

superoxide dismutase [Mn];


Pssm-ID: 182843  Cd Length: 206  Bit Score: 435.89  E-value: 1.59e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   1 MSYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLDQLPADKKTVLRNNAGGHA 80
Cdd:PRK10925   1 MSYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLDQLPADKKTVLRNNAGGHA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786  81 NHSLFWKGLKKGTTLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGDKLAVVSTANQDSPLMGEAISGAS 160
Cdd:PRK10925  81 NHSLFWKGLKKGTTLQGDLKAAIERDFGSVDNFKAEFEKAAATRFGSGWAWLVLKGDKLAVVSTANQDSPLMGEAISGAS 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446044786 161 GFPIMGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAARFAAKK 206
Cdd:PRK10925 161 GFPILGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAARFAAKK 206
SodA COG0605
Superoxide dismutase [Inorganic ion transport and metabolism];
4-201 1.08e-119

Superoxide dismutase [Inorganic ion transport and metabolism];


Pssm-ID: 440370 [Multi-domain]  Cd Length: 192  Bit Score: 337.10  E-value: 1.08e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   4 TLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLDqlpADKKTVLRNNAGGHANHS 83
Cdd:COG0605    1 ELPPLPYAYDALEPHISAETMELHHDKHHQAYVNNLNAALEGLAELEDKSLEEIIKKLS---EELKRALRNNAGGHWNHT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786  84 LFWKGLKK--GTTLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGD-KLAVVSTANQDSPLMgeaisgAS 160
Cdd:COG0605   78 LFWENLSPngGGEPTGELAAAIEADFGSFDAFKEEFKAAAAGRFGSGWAWLVVDKDgKLEIVSTPNQDNPLM------AG 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 446044786 161 GFPIMGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAAR 201
Cdd:COG0605  152 GTPLLGLDVWEHAYYLDYQNRRPDYVDAFWNVVNWDFVEKR 192
Sod_Fe_C pfam02777
Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze ...
 96-201 5.50e-62

Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.


Pssm-ID: 460691  Cd Length: 102  Bit Score: 188.02  E-value: 5.50e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   96 QGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVL-KGDKLAVVSTANQDSPLMGEAIsgasgfPIMGLDVWEHAY 174
Cdd:pfam02777   2 TGALAEAIEKDFGSFDAFKEEFNAAAAGVFGSGWAWLVYdPDGKLEIVTTPNQDNPLTDGLT------PLLGLDVWEHAY 75

                          90       100
                  ....*....|....*....|....*..
gi 446044786  175 YLKFQNRRPDYIKEFWNVVNWDEAAAR 201
Cdd:pfam02777  76 YLDYQNRRADYVKAFWNVVNWDEVEKR 102
 
Name Accession Description Interval E-value
PRK10925 PRK10925
superoxide dismutase [Mn];
1-206 1.59e-158

superoxide dismutase [Mn];


Pssm-ID: 182843  Cd Length: 206  Bit Score: 435.89  E-value: 1.59e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   1 MSYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLDQLPADKKTVLRNNAGGHA 80
Cdd:PRK10925   1 MSYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLDQLPADKKTVLRNNAGGHA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786  81 NHSLFWKGLKKGTTLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGDKLAVVSTANQDSPLMGEAISGAS 160
Cdd:PRK10925  81 NHSLFWKGLKKGTTLQGDLKAAIERDFGSVDNFKAEFEKAAATRFGSGWAWLVLKGDKLAVVSTANQDSPLMGEAISGAS 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446044786 161 GFPIMGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAARFAAKK 206
Cdd:PRK10925 161 GFPILGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAARFAAKK 206
SodA COG0605
Superoxide dismutase [Inorganic ion transport and metabolism];
4-201 1.08e-119

Superoxide dismutase [Inorganic ion transport and metabolism];


Pssm-ID: 440370 [Multi-domain]  Cd Length: 192  Bit Score: 337.10  E-value: 1.08e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   4 TLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLDqlpADKKTVLRNNAGGHANHS 83
Cdd:COG0605    1 ELPPLPYAYDALEPHISAETMELHHDKHHQAYVNNLNAALEGLAELEDKSLEEIIKKLS---EELKRALRNNAGGHWNHT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786  84 LFWKGLKK--GTTLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGD-KLAVVSTANQDSPLMgeaisgAS 160
Cdd:COG0605   78 LFWENLSPngGGEPTGELAAAIEADFGSFDAFKEEFKAAAAGRFGSGWAWLVVDKDgKLEIVSTPNQDNPLM------AG 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 446044786 161 GFPIMGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAAR 201
Cdd:COG0605  152 GTPLLGLDVWEHAYYLDYQNRRPDYVDAFWNVVNWDFVEKR 192
Sod_Fe_C pfam02777
Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze ...
 96-201 5.50e-62

Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.


Pssm-ID: 460691  Cd Length: 102  Bit Score: 188.02  E-value: 5.50e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   96 QGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVL-KGDKLAVVSTANQDSPLMGEAIsgasgfPIMGLDVWEHAY 174
Cdd:pfam02777   2 TGALAEAIEKDFGSFDAFKEEFNAAAAGVFGSGWAWLVYdPDGKLEIVTTPNQDNPLTDGLT------PLLGLDVWEHAY 75

                          90       100
                  ....*....|....*....|....*..
gi 446044786  175 YLKFQNRRPDYIKEFWNVVNWDEAAAR 201
Cdd:pfam02777  76 YLDYQNRRADYVKAFWNVVNWDEVEKR 102
PRK10543 PRK10543
superoxide dismutase [Fe];
1-204 1.33e-56

superoxide dismutase [Fe];


Pssm-ID: 182534  Cd Length: 193  Bit Score: 177.45  E-value: 1.33e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   1 MSYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESlPEFANLPVEELITKLDqlpadkkTVLRNNAGGHA 80
Cdd:PRK10543   1 MSFELPALPYAKDALAPHISAETLEYHYGKHHQTYVTNLNNLIKG-TAFEGKSLEEIVRSSE-------GGVFNNAAQVW 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786  81 NHSLFWKGL--KKGTTLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGD-KLAVVSTANQDSPLMGEAIs 157
Cdd:PRK10543  73 NHTFYWNCLapNAGGEPTGKVAEAIAASFGSFADFKAQFTDAAIKNFGSGWTWLVKNADgKLAIVSTSNAGTPLTTDAT- 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446044786 158 gasgfPIMGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAARFAA 204
Cdd:PRK10543 152 -----PLLTVDVWEHAYYIDYRNARPGYLEHFWALVNWEFVAKNLAA 193
PLN02471 PLN02471
superoxide dismutase [Mn]
 2-199 7.52e-56

superoxide dismutase [Mn]


Pssm-ID: 215262  Cd Length: 231  Bit Score: 177.02  E-value: 7.52e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   2 SYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLdqlpadkKTVLRNNAGGHAN 81
Cdd:PLN02471  30 TFTLPDLPYDYGALEPAISGEIMQLHHQKHHQTYVTNYNKALEQLDQAVEKGDASAVVKL-------QSAIKFNGGGHVN 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786  82 HSLFWKGLKK-----GTTLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGD--KLAVVSTANQDsPLMGE 154
Cdd:PLN02471 103 HSIFWKNLAPvseggGEPPHGSLGWAIDEHFGSLEALVKKMSAEGAAVQGSGWVWLGLDKElkKLVVETTANQD-PLVTK 181

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446044786 155 aisGASGFPIMGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAA 199
Cdd:PLN02471 182 ---GPSLVPLLGIDVWEHAYYLQYKNVRPDYLKNIWKVMNWKYAS 223
PTZ00078 PTZ00078
Superoxide dismutase [Fe]; Provisional
 6-198 6.50e-55

Superoxide dismutase [Fe]; Provisional


Pssm-ID: 185432 [Multi-domain]  Cd Length: 193  Bit Score: 173.05  E-value: 6.50e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   6 PSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPeFANLPVEELITKLDqlpadkkTVLRNNAGGHANHSLF 85
Cdd:PTZ00078   1 PKLPYGLKELSPHLSEETLKFHYSKHHAGYVNKLNGLIKGTP-LENKTLEELIKEYS-------GAVFNNAAQIWNHNFY 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786  86 WKGLKK--GTTLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGD-KLAVVSTANQDSPlmgeaISGASGF 162
Cdd:PTZ00078  73 WLSMGPngGGEPTGEIKEKIDEKFGSFDNFKNEFSNVLSGHFGSGWGWLVLKNDgKLEIVQTHDAGNP-----IKDNTGK 147

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 446044786 163 PIMGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEA 198
Cdd:PTZ00078 148 PLLTCDIWEHAYYIDYRNDRASYVNSWWNKVNWDFA 183
PLN02685 PLN02685
iron superoxide dismutase
 3-206 2.73e-54

iron superoxide dismutase


Pssm-ID: 215369  Cd Length: 299  Bit Score: 175.19  E-value: 2.73e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   3 YTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESlPEFANLPVEELIT----KLDQLPAdkktvlRNNAGG 78
Cdd:PLN02685  47 FELKPPPYPLDALEPHMSRETLEYHWGKHHRAYVDNLNKQIVG-TELDGMSLEDVVLitynKGDMLPA------FNNAAQ 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786  79 HANHSLFWKGLKKGTTLQ--GDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGD-----------------KL 139
Cdd:PLN02685 120 AWNHEFFWESMKPGGGGKpsGELLQLIERDFGSFERFVEEFKSAAATQFGSGWAWLAYKANrldvgnavnpcpseedkKL 199

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446044786 140 AVVSTANQDSPLMGEAisgasgFPIMGLDVWEHAYYLKFQNRRPDYIKEFW-NVVNWDEAAARFAAKK 206
Cdd:PLN02685 200 VVVKSPNAVNPLVWDY------SPLLTIDVWEHAYYLDFQNRRPDYISTFMeKLVSWEAVSARLESAK 261
PLN02184 PLN02184
superoxide dismutase [Fe]
 2-206 5.35e-51

superoxide dismutase [Fe]


Pssm-ID: 177838  Cd Length: 212  Bit Score: 163.76  E-value: 5.35e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   2 SYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESlPEFANLPVEELITKL----DQLPAdkktvlRNNAG 77
Cdd:PLN02184  10 NYVLKPPPFALDALEPHMSKQTLEFHWGKHHRAYVDNLKKQVLG-TELEGKPLEHIIHSTynngDLLPA------FNNAA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786  78 GHANHSLFWKGLKKGT--TLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGDKLAVVSTANQDSPLMgea 155
Cdd:PLN02184  83 QAWNHEFFWESMKPGGggKPSGELLALLERDFTSYEKFYEEFNAAAATQFGAGWAWLAYSNEKLKVVKTPNAVNPLV--- 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446044786 156 isgASGFPIMGLDVWEHAYYLKFQNRRPDYIKEFW-NVVNWDEAAARFAAKK 206
Cdd:PLN02184 160 ---LGSFPLLTIDVWEHAYYLDFQNRRPDYIKTFMtNLVSWEAVSARLEAAK 208
PLN02622 PLN02622
iron superoxide dismutase
 3-203 1.16e-48

iron superoxide dismutase


Pssm-ID: 166263 [Multi-domain]  Cd Length: 261  Bit Score: 159.41  E-value: 1.16e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786   3 YTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKL----DQLPAdkktvlRNNAGG 78
Cdd:PLN02622  48 YGLKTPPYPLDALEPYMSRRTLEVHWGEHHRGYVEGLNKQLAKDDILYGYTMDELVKVTynngNPLPE------FNNAAQ 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786  79 HANHSLFWKGLKK--GTTLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGD--KLAVVSTANQDSPLMGE 154
Cdd:PLN02622 122 VWNHDFFWESMQPggGDMPELGVLEQIEKDFGSFTNFREKFTEAALTLFGSGWVWLVLKREerRLEVVKTSNAINPLVWD 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446044786 155 AIsgasgfPIMGLDVWEHAYYLKFQNRRPDYIKEFWN-VVNWDEAAARFA 203
Cdd:PLN02622 202 DI------PIICLDVWEHAYYLDYKNDRGKYVNAFMNhLVSWNAAMARMA 245
Sod_Fe_N pfam00081
Iron/manganese superoxide dismutases, alpha-hairpin domain; superoxide dismutases (SODs) ...
 2-90 1.53e-40

Iron/manganese superoxide dismutases, alpha-hairpin domain; superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. N-terminal domain is a long alpha antiparallel hairpin. A small fragment of YTRE_LEPBI matches well - sequencing error?


Pssm-ID: 425457  Cd Length: 82  Bit Score: 132.81  E-value: 1.53e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446044786    2 SYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLpEFANLPVEELITKldqlpaDKKTVLRNNAGGHAN 81
Cdd:pfam00081   1 SYELPDLPYAYDALEPHISKETMEIHHTKHHQTYVNNLNAALEGL-EEARKPLEELIIK------ALLGGLFNNGGGHWN 73


                  ....*....
gi 446044786   82 HSLFWKGLK 90
Cdd:pfam00081  74 HSLFWKNLS 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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