|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
21-434 |
2.22e-172 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 488.81 E-value: 2.22e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 21 IFASAFGNALEFFDFGVYNFFVVYISTLFFPpSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIAL 100
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFP-SGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 101 MSLGTLMIGIAPTYATAGYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATTFGGIVALG 180
Cdd:cd17368 80 MALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 181 LSAWLPFATgsetvMAEWGWRVPFFIGVLLAPIGCWLRLSLENDAPEVANKKSAAASEsTFSLLLQHKATLANGVLLAIG 260
Cdd:cd17368 160 LSLTLTAEA-----LAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRRE-LFALLANNRRIILLGMLLVAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 261 STVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISRVMVLLCSCPSFWLLVNYP 340
Cdd:cd17368 234 STVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 341 SPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRALGFALVYSIGVAIFGGFAQYFATQSIVLLESLTAPAWYLGGGT 420
Cdd:cd17368 314 SFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAA 393
|
410
....*....|....
gi 446047593 421 LLSMLALLFVKEPA 434
Cdd:cd17368 394 LLGLLATLMLRETA 407
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
27-424 |
6.54e-91 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 280.70 E-value: 6.54e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 27 GNALEFFDFGVYNFFVVYISTLFFPPSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIALMSLGTL 106
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 107 MIGIAPTYATAGYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATTFGGIVALGLSAWLp 186
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLL- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 187 fatgSETVMAEWGWRVPFFIGVLLAPIGCWLRLSLENDAP-EVANKKSAAASESTFSLLLQHKATLANGVLLAIGSTVAT 265
Cdd:TIGR00883 160 ----GDDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVfEKAQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 266 YISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISRVMVLLCSCPSFWLLVNYPSPGML 345
Cdd:TIGR00883 236 YLITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLF 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446047593 346 LTVVFVMVSFTTLGGVPVMLLISELLPKRIRALGFALVYSIGVAIFGGFAQYFATQSIVLLESLTAPAWYLGGGTLLSM 424
Cdd:TIGR00883 316 FFLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIGL 394
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
18-429 |
7.07e-86 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 268.24 E-value: 7.07e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 18 KRVIFASAFGNALEFFDFGVYNFFVVYISTLFFPPSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFT 97
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 98 IALMSLGTLMIGIAPTYATAGYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATTFGGIV 177
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 178 ALGLSAWLpfatgSETVMAEWGWRVPFFIGVLLAPIGCWLRLSL-ENDAPEVANKKSAAASESTFSLLLQHKATLANGVL 256
Cdd:cd17369 161 FLLLSALL-----SDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLeETPVFRRAKEAGQVVRAPLVEVLRRHWRALLLAIG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 257 LAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISRVMVLLCSCPSFWLL 336
Cdd:cd17369 236 LRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 337 VNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRALGFALVYSIGVAIFGGFAQYFATQSIVLLESLTAPAWYL 416
Cdd:cd17369 316 DTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYL 395
|
410
....*....|...
gi 446047593 417 GGGTLLSMLALLF 429
Cdd:cd17369 396 AALAVISLVAALF 408
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
21-432 |
8.43e-86 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 268.01 E-value: 8.43e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 21 IFASAFGNALEFFDFGVYNFFVVYISTLFFPPSaDHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIAL 100
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSG-DPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 101 MSLGTLMIGIAPTYATAGYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATqglaTTFGGIVALG 180
Cdd:cd17367 80 MAAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVT----LIGGQLLALG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 181 LSAWLPFaTGSETVMAEWGWRVPFFIGVLLAPIGCWLRLSLENDAPEVANKKSAAASESTFSLLLQHKATLANGVLLAIG 260
Cdd:cd17367 156 VLLVLQH-TLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRELRRHPRELLLVVGLTAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 261 STVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISRVMVLLCSCPSFWLLVNYP 340
Cdd:cd17367 235 GTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTD 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 341 SPGMLLTVVFVMVSFTTlGGVPVMLLIS-ELLPKRIRALGFALVYSIGVAIFGGFAQYFATQSIVLLESLTAPaWYLGGG 419
Cdd:cd17367 315 SPYTAFALVLVGLVFLS-GYTSINAVVKaELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVFF-WYVAGL 392
|
410
....*....|...
gi 446047593 420 TLLSMLALLFVKE 432
Cdd:cd17367 393 IAISLVVYLRMPE 405
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
13-430 |
1.29e-78 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 250.25 E-value: 1.29e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 13 KKPSGKRVIFASAFGNALEFFDFGVYNFFVVYISTLFFPpSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKP 92
Cdd:PRK15075 9 SRESKARAILRVTSGNFLEMFDFFLFGFYATAIAKTFFP-AGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRK 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 93 AMVFTIALMSLGTLMIGIAPTYATAGYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATT 172
Cdd:PRK15075 88 GLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 173 FGGIVALGLSAWLPFATgsetvMAEWGWRVPFFIGVLLAPIGCWLRLSLEnDAPEVANKKSAAASESTFSLLLQHKATLA 252
Cdd:PRK15075 168 FAALLGYLLNQWLSPAQ-----MAEWGWRIPFLIGCLIVPFIFLIRRSLE-ETEEFLARKHRPSMREIFRSLAANWRIVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 253 NGVLLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISRVMVLLCSCPS 332
Cdd:PRK15075 242 AGMLMVAMTTVSFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVLAILTAYPA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 333 FWLLVNYPSPGMLLTVVfVMVSF--TTLGGVPVMLLiSELLPKRIRALGFALVYSIGVAIFGGFAQYFATQSIVLLESLT 410
Cdd:PRK15075 322 LSWLVAAPSFARMLAVE-LWLSFlyGSYNGAMVVAL-TEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGDKA 399
|
410 420
....*....|....*....|
gi 446047593 411 APAWYLGGGTLLSMLALLFV 430
Cdd:PRK15075 400 APGYWLSFAAVCGLIATLVL 419
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
21-434 |
4.72e-63 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 207.98 E-value: 4.72e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 21 IFASAFGNALEFFDFGVYNFFVVYISTLFFPpSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIAL 100
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFP-GGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIIL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 101 MSLGTLMIGIAPTYATAGYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATTFGGIVALG 180
Cdd:cd17366 80 MAASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 181 LSAWLPfatgsETVMAEWGWRVPFFIGVLLAPIGCWLRLSLendapevankksaaasestfslllqhkatlangvLLAIG 260
Cdd:cd17366 160 LTLLLT-----EAQMLDWGWRIPFLIAAPLGLVGLYLRRPL----------------------------------LICIG 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 261 STVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLV----GMLCDSVGRKKLILISRVMVLLCSCPSFwLL 336
Cdd:cd17366 201 LVLVFNVTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLqpflGRLSDRVGRKPVYAAGLAGLLVLAVPAF-LL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 337 VNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRALGFALVYSIGVAIFGGFAQYFATQSIVLLESLTAPAWYL 416
Cdd:cd17366 280 MNSGSIAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAYYL 359
|
410
....*....|....*...
gi 446047593 417 GGGTLLSMLALLFVKEPA 434
Cdd:cd17366 360 MVAAVVGLVAVLFLTETA 377
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
1-438 |
3.72e-58 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 196.95 E-value: 3.72e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 1 MTAIVNESVGVKKKPSGKRVIFA---SAFGNALEFFDFGVYNFFVVYISTLFFPpSADHNVALLLAFATFGVSFFMRPLG 77
Cdd:PRK10406 1 MAESTVTADSKLTSSDTRRRIWAivgASSGNLVEWFDFYVYSFCSLYFAHIFFP-SGNTTTQLLQTAGVFAAGFLMRPIG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 78 GIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYATAGYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRG 157
Cdd:PRK10406 80 GWLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 158 FYSSWSLATQGLATTFGGIVALGLSAWLpfatgSETVMAEWGWRVPFFIGVLLAPIGCWLRLSLEndapEVANKKSAAAS 237
Cdd:PRK10406 160 FYASFQYVTLIGGQLLALLVVVVLQQTL-----EDAELREWGWRIPFALGAVLAVVALWLRRQLD----ETSQQETRALK 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 238 ES-TFSLLLQHKATLangvLLAIGSTVATYISLFYYGTWAAKYL----AMPQHYSHAAMLLAGVITFVGALLVGMLCDSV 312
Cdd:PRK10406 231 EAgSLKGLWRNRRAF----IMVLGFTAAGSLCFYTFTTYMQKYLvntaGMHANVASGIMTAALFVFMLIQPLIGALSDKI 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 313 GRKKLILISRVMVLLCSCPSFWLLVNYPSP---GMLLTVVFVMVSF-TTLGGVpvmlLISELLPKRIRALGFALVYSIGV 388
Cdd:PRK10406 307 GRRTSMLCFGSLAALFTVPILSALQNVSSPyaaFGLVMCALLIVSFyTSISGI----LKAEMFPAQVRALGVGLSYAVAN 382
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 446047593 389 AIFGGFAQYFATqSIVLLESLTAPAWYLGGGTLLSMLALLFVKEPAKELQ 438
Cdd:PRK10406 383 ALFGGSAEYVAL-SLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKGKGMR 431
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
18-434 |
1.71e-56 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 193.77 E-value: 1.71e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 18 KRVIFASAFGNALEFFDFGVYNFFVVYISTLFFPpSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFT 97
Cdd:PRK10642 15 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFFP-GADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAIT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 98 IALMSLGTLMIGIAPTYATAGYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWslatqglaTTFGGIV 177
Cdd:PRK10642 94 IVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSW--------LDFGSIA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 178 AL----GLSAWLPFATGsETVMAEWGWRVPFFIGVLLAPIGCWLRLSLE--------NDAPEVANKKSAAASE--STFSL 243
Cdd:PRK10642 166 GFvlgaGVVVLISTIVG-EANFLDWGWRIPFFIALPLGIIGLYLRHALEetpafqqhVDKLEQGDREGLQDGPkvSFKEI 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 244 LLQHKATLangvLLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLV----GMLCDSVGRKKLIL 319
Cdd:PRK10642 245 ATKHWRSL----LTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVqpvmGLLSDRFGRRPFVI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 320 ISRVMVLLCSCPSFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLiSELLPKRIRALGFALVYSIGVAIfGGFAQYFA 399
Cdd:PRK10642 321 LGSVALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTL-PAMFPTHIRYSALAAAFNISVLV-AGLTPTLA 398
|
410 420 430
....*....|....*....|....*....|....*
gi 446047593 400 TQSIVLLESLTAPAWYLGGGTLLSMLALLFVKEPA 434
Cdd:PRK10642 399 AWLVESTQNLMMPAYYLMVVAVIGLITGVTMKETA 433
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
21-428 |
2.48e-51 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 176.64 E-value: 2.48e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 21 IFASAFGNALEFFDFGVYNFFVVYISTLFfppsaDHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIAL 100
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF-----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 101 MSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATTFGGIVALG 180
Cdd:cd17316 76 FGLATLLIGLLPTP--------ILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 181 LSAWLPFatgsetvmaEWGWRVPFFIGVLLAPIGCWLRLSlendapevankksaaasestfslllqhkatlangVLLAIG 260
Cdd:cd17316 148 LIPLLSG---------DWGWRILFLIGALPALLALLLRRR----------------------------------TLLLIL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 261 STVATYISLFYYGTWAAKYLAMPQHYSHAA----MLLAGVITFVGALLVGMLCDSVGRKKLILISRVMVLLCSCPSFWLL 336
Cdd:cd17316 185 LWFFISFGYYGLTTFLPTYLQTVLGLSPATsslyLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 337 VNypSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRALGFALVYSIGVAIFGGFAqYFATQSIVLLESLTAPAWYL 416
Cdd:cd17316 265 SG--SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAP-PLIALLLASTGGTGVPALIL 341
|
410
....*....|..
gi 446047593 417 GGGTLLSMLALL 428
Cdd:cd17316 342 ALLAIVALIVAL 353
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
18-433 |
4.94e-45 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 162.21 E-value: 4.94e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 18 KRVIFASAFGNALEFFDFGVYNFFVVYISTLFFPPSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFT 97
Cdd:PRK09952 21 RRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLT 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 98 IALMSLGTLMIGIAPTYATAGYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLattfGGIV 177
Cdd:PRK09952 101 VWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGV----GLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 178 ALGLSAWLPFATGSETVMAeWGWRVPFFIGVLLAPIGCWLRLSLENDAP---EVANKKSAAASESTFSLLLQHKATLANG 254
Cdd:PRK09952 177 STGLVSLISMMTTDEQFLS-WGWRIPFLFSIVLVLIALWVRNGMEESAEfeqQQHEQAAAKKRIPVIEALLRHPGAFLKI 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 255 VLLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISRVMVLLCSCPSFW 334
Cdd:PRK09952 256 IALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFM 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 335 LLvnyPSPGMLLTVVFVMVSFTTLGGVPVML---LISELLPKRIRALGFALVYSIGVAIFGGFAQYFAtqsiVLLESLTA 411
Cdd:PRK09952 336 AL---EAQSIFWIVFFSIMLANIAHDMVVCVqqpMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIA----AALVTYFG 408
|
410 420
....*....|....*....|....*..
gi 446047593 412 PAW-----YLGGGTLLSMLALLFVKEP 433
Cdd:PRK09952 409 GSWhsvaiYLLAGCLISAMTALLMKDN 435
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-435 |
1.83e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 112.67 E-value: 1.83e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 19 RVIFASAFGNALEFFDFGVYNFFVVYISTLFfppsadhNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTI 98
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEF-------GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 99 ALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATTFGGIVA 178
Cdd:COG2223 78 LLLGIGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 179 LGLsawlpfatgsetvMAEWGWRVPFFI-GVLLAPIGCWLRLSLENDAPEVAnkKSAAASESTFSLLLQHKATLANGVLL 257
Cdd:COG2223 150 PLL-------------IAAFGWRNAFLIlGILLLVVAVLAWLFLRDPPAGAA--AAAKASLRDQLEALRDPRFWLLSLLY 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 258 AIgstvaTYISLFYYGTWAAKYLAMPQHYSHA-AMLLAGVITFVGAL---LVGMLCDSVGRKKLILISRVMVLLCSCPSF 333
Cdd:COG2223 215 FG-----TFGSFIGFSSWLPPYLVDQFGLSAAtAGLLAALFALLGALgrpLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 334 WLLvnyPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRALGFALVYSIGvAIFGGFAQYFATQSIVLLESLTAPA 413
Cdd:COG2223 290 LAL---GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAG-GLGGFLGPLLFGALLDATGSYTAAF 365
|
410 420
....*....|....*....|..
gi 446047593 414 WYLGGGTLLSMLALLFVKEPAK 435
Cdd:COG2223 366 LVFAVLALVALVLTLLLYRRPR 387
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
20-387 |
1.14e-26 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 111.59 E-value: 1.14e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 20 VIFASAFGNALEFFDFGVYNFFVVYISTLFFPPSADHN--VALLLAFATFGVSFFM--RPLGGIIVGAWADRFGRKPAMV 95
Cdd:pfam00083 1 VALVAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVssLAALSVLSGLIVSIFSvgCFIGSLFAGKLGDRFGRKKSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 96 FTIALMSLGTLMIGIAPtyataGYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWslatQGLATTFGG 175
Cdd:pfam00083 81 IANVLFVIGAVLQGAAK-----GKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSL----YQLAITFGI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 176 IVALGlsawlpFATGSETVMAEWGWRVPFFIGVLLAPIGCWLRL-------------------------------SLEND 224
Cdd:pfam00083 152 LLAYI------FGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLflpesprwlvekgrleearevlaklrgvpdvDRELD 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 225 APEVANKKSAAASESTFSLLLQHKAT---LANGVLLAIGSTVATYISLFYYGTWAAKYLAMPQhySHAAMLLAGVITFVG 301
Cdd:pfam00083 226 EIKDSLEAGQEAEKASWKELFSTKTRrqrLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSD--SFLVTIIVGVVNFVF 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 302 ALLVGMLCDSVGRKKLILISRVMVLLC----SCPSFWLLVNYPSPGMLLTV-VFVMVSFTTLGGVPVM-LLISELLPKRI 375
Cdd:pfam00083 304 TFIAIFLVDRFGRRPLLLLGAAGMAICfvilGIVALLGVSKSDWAGIVAIVfIALFIAFFAMGWGPVPwVIVSELFPLSV 383
|
410
....*....|..
gi 446047593 376 RALGFALVYSIG 387
Cdd:pfam00083 384 RSKAMALATAAN 395
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-387 |
2.93e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 108.52 E-value: 2.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 14 KPSGKRVIFASAFGNALEFFDFGVYNFFVVYIStlffppsADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPA 93
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIA-------ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 94 MVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATTF 173
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPSL--------WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 174 GGIVALGLSAWlpfatgsetvmaeWGWRVPFFIGVLLAPIGCWLRLSLendAPEVANKKSAAASESTFSLLlqHKATLAN 253
Cdd:COG2814 150 GPLLGGLLADL-------------FGWRWVFLVNAVLALLALLLLLRL---LPESRPAARARLRGSLRELL--RRPRLLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 254 GVLLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISrvmvLLCSCPSF 333
Cdd:COG2814 212 LLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG----LLLLALGL 287
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446047593 334 WLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRALGFALVYSIG 387
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
22-429 |
1.34e-24 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 104.69 E-value: 1.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 22 FASAFGNALEFFDFGVYNFFVVYISTLFfpPSADHNVALLLAFATFGVSFfmrplGGIIVGAWADRFGRKPAMVFTIALM 101
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEF--GLDEAEAGLLGTVTLAGGAI-----GGILGGILADRFGRVRVLVITILLF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 102 SLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFysswSLATQGLATTFGGIVALGL 181
Cdd:cd17371 75 AVFTLLCGFAQNY--------WQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGK----ALGYVQSGWAVGWLLATLL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 182 SAWL-PFATGsetvmaEWGWRVPFFIGVLLAPIGCWLRLSLENDAPEVANKKSAAASESTFSLL-LQHKATL---ANGVL 256
Cdd:cd17371 143 AALLfPLLPP------EIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLReLFSPPLLrttLLASL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 257 LAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISRvmvlLCSCPSFWLL 336
Cdd:cd17371 217 LATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFA----LGSAISILLY 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 337 VNYPSPGMLLTVVFVMVSFTTLGGVPVML-LISELLPKRIRALGFALVYSIGVAIFGGFAqyFATQSIVLLESLTAPAWY 415
Cdd:cd17371 293 FFLPLSPTLILILGFPLGFFASGPFSGMGaYLTELFPTAVRATAQGFCYNVGRIIGALFP--FLVGFLATSGSLGTAIAV 370
|
410
....*....|....
gi 446047593 416 LGGGTLLSMLALLF 429
Cdd:cd17371 371 FAAVYYIAGLVLAL 384
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-436 |
1.87e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 103.80 E-value: 1.87e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 12 KKKPSGKRVIFASAFGNALEFFDFGVYNFFVVYISTLFFPPSADhnvalllAFATFGVSFFMRPLGGIIVGAWADRFGRK 91
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQ-------LGLLASAFFLGYALGQIPAGLLADRFGRR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 92 PAMVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLAtqglAT 171
Cdd:COG2271 76 RVLAIGLLLWGLATLLFGFATSF--------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNA----GG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 172 TFGGIVALGLSAWLpfatgsetvMAEWGWRVPFFIGVLLAPIGCWLRlslendapevankksaaasestfslllqhkatl 251
Cdd:COG2271 144 PLGGALAPPLLGWL---------LAAFGWRAAFLILGLPGLLLALLR--------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 252 angVLLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITF----VGALLVGMLCDSVGRKKLILIsrVMVLL 327
Cdd:COG2271 182 ---FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFlagiVGSLLGGWLSDRLGRRRKLVL--AIGLL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 328 CSCPSFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRALGFALVYSIGvaIFGGFAQYFATQSIVLLE 407
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFG--FLGGALGPLLVGYLLDAT 334
|
410 420
....*....|....*....|....*....
gi 446047593 408 SLTAPAWYLGGGTLLSMLALLFVKEPAKE 436
Cdd:COG2271 335 GYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-308 |
1.10e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 97.57 E-value: 1.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 8 SVGVKKKPSGKRVIFASAFGNALEFFDFGVYNFFVVYISTLFFPPSADHNValllafaTFGVSFFMRPLGGIIVGAWADR 87
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGW-------IVSAYLLGRAIGLLLFGRLGDR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 88 FGRKPAMVFTIALMSLGTLMIGIAPTYATagywgtatLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQ 167
Cdd:COG0477 76 YGRKRVLLIGLLLFGLASLLCGLAPSPEL--------LIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 168 GLATTFGGIVALGLSAWlpfatgsetvmaeWGWRVPFFIGVLLAPIGCWLRLSLENDAPEVANKKSAAASESTFSLLLQH 247
Cdd:COG0477 148 GLGLALGPLLGGLLVAA-------------LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALA 214
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446047593 248 KATLANGVLLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGML 308
Cdd:COG0477 215 LLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALL 275
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
19-270 |
1.16e-22 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 100.16 E-value: 1.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 19 RVIFASAFGNALEFFDFgvynffvVYISTLFFPPSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTI 98
Cdd:PRK03893 20 KAFSAAWLGYLLDGFDF-------VLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 99 ALMSLGTLMIGIAPtyataGYWgtaTLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLAtqglATTFGGIVA 178
Cdd:PRK03893 93 VLFSVGTLACGFAP-----GYW---TLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLIS----GFSIGAVVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 179 LGLSAWlpfatgsetVMAEWGWRVPFFIGVLLAPIGCWLRLSLENDAPEVANKKSAAASESTFSLLLQHKATLANgvlla 258
Cdd:PRK03893 161 AQVYSL---------VVPVWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKAPVRTMVDILYRGEHRIIN----- 226
|
250
....*....|..
gi 446047593 259 IGSTVATYISLF 270
Cdd:PRK03893 227 ILLTLAAAAALW 238
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
67-390 |
1.16e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 87.25 E-value: 1.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 67 FGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASMSL 146
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY--------WQLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 147 LVESAPANRRGFYSSWSLATQGLATTFGGIVALGLSAWlpfatgsetvmaeWGWRVPFFIGVLLAPIGCWLRLSL--END 224
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA-------------LGYRAPFLVCAALALLALVLALLLlpEPR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 225 APEVANKKSAAASESTFSLLLQHKATLANGVLLAIGStVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALL 304
Cdd:cd17325 176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLA-FAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPP 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 305 VGMLCDSVGRKKLILISRVMVLLCscpsFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRALGFAL-- 382
Cdd:cd17325 255 AGKLSDRIGRKPLILIGLLLSAVA----LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLfn 330
|
....*....
gi 446047593 383 -VYSIGVAI 390
Cdd:cd17325 331 tAFSLGMVL 339
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
15-400 |
4.75e-18 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 85.75 E-value: 4.75e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 15 PSGKRVIFASAFGNALEFFDFGVYnFFVVYIStlffppSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAM 94
Cdd:PRK12307 14 RPQKNALFSAWLGYVFDGFDFMLI-FYIMYLI------KADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 95 VFTIALMSLGTLMIGIAPtyatagywGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLattfG 174
Cdd:PRK12307 87 MWSIVAYSVGTGLSGLAS--------GVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGI----G 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 175 GIVAlglsawlpfATGSETVMAEWGWRVPFFIGVLLAPIGCWLRLSLENDAPEVANKKS--AAASESTFSLLLQHKATLA 252
Cdd:PRK12307 155 NIIA---------AYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSgkGKHSQSAWSVFSLSMKGLF 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 253 NGVLLAIGSTVATYISLFYYGTWAAKYLaMPQHYSHAA---------MLLAGVITFVGALLVGMLCDSVGRKKLILISRV 323
Cdd:PRK12307 226 NRAQFPLTLCVFIVLFSIFGANWPIFGL-LPTYLAGEGfdtgvvsnlMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446047593 324 MVLLCSCPSFWLLVNYPSpgmLLTVVFVMVSFTTLG-GVPVMLLISELLPKRIRALGFALVYSIGvAIFGGFAQYFAT 400
Cdd:PRK12307 305 MSFLFIFPLFRIPQDNYL---LLGACLFGLMATNVGvGGLVPKFLYDYFPLEVRGLGTGLIYNLA-ATSGTFNSMAAT 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
35-387 |
4.51e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.00 E-value: 4.51e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 35 FGVYNFFVVYISTLFFPPSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTY 114
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 115 ATagywgtatLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATTFGGIVALGLSAWlpfatgsetv 194
Cdd:pfam07690 86 WL--------LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL---------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 195 maeWGWRVPFFIGVLLAPIGCWLRLSLENDAPEVANKKSAAASESTFSLLLQHKATLANGVLLAIGSTVATYISLFYYGT 274
Cdd:pfam07690 148 ---FGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 275 WAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISRVMVLLCSCpSFWLLVNYPSPGMLLTVVFVMVS 354
Cdd:pfam07690 225 LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL-GLLLLSLTLSSLWLLLALLLLGF 303
|
330 340 350
....*....|....*....|....*....|...
gi 446047593 355 FTTLGGVPVMLLISELLPKRIRALGFALVYSIG 387
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
19-431 |
9.17e-16 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 78.38 E-value: 9.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 19 RVIFASAFGNALEFFDFGVYNFFVVYISTLFfpPSADHNVALLLAFATFGVSFfmrplGGIIVGAWADRFGRKPAMVFTI 98
Cdd:cd17359 1 LISLVAALGGLLFGYDTGVINGALPFLQTDF--NLTPFLEGLVVSSALLGAAI-----GALFAGRLADRFGRRKTLLISA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 99 ALMSLGTLMIGIAPTyatagywgTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSwslaTQGLATTFGGIVA 178
Cdd:cd17359 74 VLFFISALGSAFSPN--------FTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVS----LNQLMIVFGQLLA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 179 LgLSAWLPFATGSETVMAEWGWRVPFFIGVLLAPIGCWLRLSLendapevankksaaaSESTFSLLLQHKATLANGVLLA 258
Cdd:cd17359 142 Y-IVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFI---------------PESPRWLVSKGKPILIIGIGLA 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 259 IGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILI----SRVMVLLCSCpSFW 334
Cdd:cd17359 206 IFQQFVGINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIgsigMAISLLLIGT-AFY 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 335 LLVNYPSPG--MLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRALGfalvysIGVAIFGG-FAQYFATQSIVLLESLTA 411
Cdd:cd17359 285 FAPGSQASGivALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLA------MGIAVFFLwIANFLVSLTFPILLAAFG 358
|
410 420
....*....|....*....|
gi 446047593 412 PAWYLGGGTLLSMLALLFVK 431
Cdd:cd17359 359 LAFTFLIFAVICVLAFLFVW 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
76-395 |
6.44e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 75.66 E-value: 6.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 76 LGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASMSLLVESAPANR 155
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF--------ALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 156 RGFysswSLATQGLATTFGGIVALGLSAWLpfatgsetvMAEWGWRVPF-FIGVLLAPIGCWLRLSLENDAPEVANKKSA 234
Cdd:cd17324 121 RGR----AIGLVFSGLTLGLVLGRPLGGLL---------GQLLGWRAAFlAIAVLALLAALLLWRLLPSLPPKKPGSLGL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 235 AASestFSLLLQHKAtlangVLLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAA----MLLAGVITFVGALLVGMLCD 310
Cdd:cd17324 188 LSS---LLLLLRNPR-----LRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAiiglLLLFGVAGVVGSPLAGRLAD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 311 SVGRKKLILISRVMVLLCscpsFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPK-RIRALG-FALVYSIGV 388
Cdd:cd17324 260 RGGRRALLIALLLLAAAL----LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEaRGLASSlYLAAYNLGG 335
|
....*..
gi 446047593 389 AIFGGFA 395
Cdd:cd17324 336 ALGAALG 342
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
61-392 |
7.39e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 72.77 E-value: 7.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 61 LLAFATFGVSFfmrplGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAptyatagyWGTATLVLARLIQGVAAGGEV 140
Cdd:TIGR00895 57 LFSAGLIGMAF-----GALFFGPLADRIGRRRVLLWSILLFSVFTLLCALA--------TNVTQLLILRFLAGLGLGGLM 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 141 GASMSLLVESAPANRRGFYsswsLATQGLATTFGGIVALGLSAWLpfatgsetvMAEWGWRVPFFIG-----VLLAPIGC 215
Cdd:TIGR00895 124 PNLNALVSEYAPKRFRGTA----VGLMFCGYPIGAAVGGFLAGWL---------IPVFGWRSLFYVGgiaplLLLLLLMR 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 216 WLRLSLE-----------------------NDAPEVANKKSAAASESTFSLLLQHKATLANGVLLAIGsTVATYISLFYY 272
Cdd:TIGR00895 191 FLPESIDflvskrpetvrrivnaiapqmqaEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLL-YFMLLVGVYFL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 273 GTWAAKyLAMPQHYSHAAMLLAGVITFVG----ALLVGMLCDSVGRKKLILISrvmvLLCSCPSFWLLVNYPSPGMLLTV 348
Cdd:TIGR00895 270 TNWLPK-LMVELGFSLSLAATGGALFNFGgvigSIIFGWLADRLGPRVTALLL----LLGAVFAVLVGSTLFSPTLLLLL 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446047593 349 VFVMVSFTTLGGVPVMLLISELLPKRIRALGFALVYSIG--VAIFG 392
Cdd:TIGR00895 345 GAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGrlGAIIG 390
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
23-382 |
1.04e-11 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 66.06 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 23 ASAFGNALEFFDFGVYNFFVVYISTLFFPPSADHN----VALLLAFATfgvsffmrpLGGIIVGAWADRFGRKPAMVFTI 98
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLqglvVSSLLLGAA---------IGSLFGGPLADRFGRRKSLLIAA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 99 ALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSwslaTQGLATTFGGIVA 178
Cdd:cd17315 72 VLYVIGALLSALAPNV--------WVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGT----LNQLMITFGILLA 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 179 LGLSawLPFATgsetvMAEWGWRVPFFIGVLLAPIGCWLRLSLENDAPevankksaaasestfslllqhkatLANGVLLA 258
Cdd:cd17315 140 YLLG--LALSL-----SPPGWWRLMFALAAVPALLQLLLMFFLPESRA------------------------LLVGVGLQ 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 259 IGSTVATYISLFYYGTWAAKyLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISRV-----MVLLCSCPSF 333
Cdd:cd17315 189 LLQQLTGINAVMYYAPTIFK-SAGGGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAgmaasLLLLAIAFLL 267
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446047593 334 WLLVNYPSPGMLLTVVFVMVSF-TTLGGVPvMLLISELLPKRIRALGFAL 382
Cdd:cd17315 268 PALAKAAGWLALLGILLYIAAFaMGAGPVP-WLLLSEIFPLRIRGKGMAI 316
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
76-386 |
2.27e-11 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 65.36 E-value: 2.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 76 LGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAptyatagYWGTA--TLVLARLIQGVAAGGEVGASMSLLVESAPA 153
Cdd:cd17357 64 IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLS-------KSAKSpeLLIFGRFLVGIACGLSTGFVPMYLQEISPS 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 154 NRRGFYSSWSlatqGLATTFGGIVALGLSawLPFATGSETvmaewGWRVPFFIGVLLAPIGC-----------WLRLS-- 220
Cdd:cd17357 137 ELRGALGSLT----QIGVTLGILLGQVFG--LPSVLGTET-----LWPYLLFFPGIPALLQLaalpffpespkFLLISkg 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 221 -----------LENDAPEVAN------KKSAAASESTFSLLLQ--HKATLANGVLLAIGSTVATYIS----LFYYGTWAA 277
Cdd:cd17357 206 deeeaekslkfLRGIEDDVDQeleeikKESEQMGDQKQVSLMQllRDPSLRLPLLLVLVVSASQQFSginaIFFYSTFIF 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 278 KYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISRVMVLLCSCP-SFWLLVNYPSPGM---LLTVVFVMV 353
Cdd:cd17357 286 ENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLmSVFLFLSEQNSWMsygCIVAIFLFI 365
|
330 340 350
....*....|....*....|....*....|....
gi 446047593 354 SFTTLGGVPV-MLLISELLPKRIRALGFALVYSI 386
Cdd:cd17357 366 FFFAIGLGPIpWFIGAELFPQAPRSAAQSLGSSV 399
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-431 |
8.55e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.38 E-value: 8.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 12 KKKPSGKRVIFASAFGNALEFFDFGVYNFFVVYI--STLFFPPSAdhnVALLLAFATFgVSFFMRPLGGIIVGAWADRFG 89
Cdd:COG2211 3 AKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFytDVLGLSAAL---VGLILLVARL-WDAITDPLIGALSDRTRTRWG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 90 -RKPAMVFTIALMSLGTLMIGIAPTYATAGY--WGTATLVLARLIQGVAaggeVGASMSLLVE-SAPANRRGFYSSWSLA 165
Cdd:COG2211 79 rRRPWILIGAIPLALSFVLLFTAPDLSPTGKliYALVTYLLLGLAYTLV----NIPYSALGAElTPDYEERTRLSSWRFA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 166 TQGLATTFGGIVALGLSAWLPfatgsetVMAEWGWRVPFFIGVLLAPIGCWLRLSLENDAPEVANKKSAAASesTFSLLL 245
Cdd:COG2211 155 FAGLGGLLASVLPPPLVAAFG-------GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKE--SLKALL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 246 QHKATLANgVLLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISrvMV 325
Cdd:COG2211 226 KNRPFLLL-LLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG--LL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 326 LLCSCPSFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLP-------KRIRALGFA-------LVYSIGVAIF 391
Cdd:COG2211 303 LAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGiftfaikLGQALAGALA 382
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 446047593 392 GGFAQYF-----ATQSIVLLESLTAPAWYLGG-GTLLSMLALLFVK 431
Cdd:COG2211 383 GLLLALFgyvagAAQSPSALTGIRLLFFLLPAvLLLLAALLLLFYP 428
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
68-433 |
3.35e-10 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 61.52 E-value: 3.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 68 GVSFFMRPLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYATAGYWGTatLVLARLIQGVAAGGEVGASMSLL 147
Cdd:cd17364 46 AAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMGW--LIFFRFLLGIGIGGDYPLSATIM 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 148 VESAPANRRGFYSSWSLATQGLATTFGGIVALGLSAWLPFATGSETVM-AEWGWRVPFFIGVLLAPIGCWLRLSLendap 226
Cdd:cd17364 124 SEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGTYHhADLVWRIVLGLGAIPALSVLYFRKHL----- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 227 evankksAAASESTFSLLLqhkATLANGVLlaiGSTVATYIslFYYGTWAAKYLAMpqHYSHAAMLLAGVITFVGALLVG 306
Cdd:cd17364 199 -------LGTAGTWFLLDI---AFYGQNLF---QSTIISAI--GFSKTMNAYQELF--NIAVGQLIIALAGTVPGYWFTV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 307 MLCDSVGRKKLIL----ISRVMVLLCSCPSFWLLVNYPSPGMLLTVVFVMVSF---TTLGGVPvmlliSELLPKRIRALG 379
Cdd:cd17364 262 FLIDRIGRKKIQMmgffGMTIFLLILAGPYDHWKISTIGFFVLYGLTFFFSNFgpnTTTFIVP-----AEVFPARVRSTC 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446047593 380 FALVYSIGV--AIFGGFAQYFATQSIVLLESLtapaWYLGGGTLLSML-ALLFVKEP 433
Cdd:cd17364 337 HGISAASGKigAIVGSFLFLSLTQNIGVRNVL----IILAGVALLGIIlTLLFPEEK 389
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
76-395 |
3.44e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 61.06 E-value: 3.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 76 LGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTyatagywgTATLVLARLIQGVAAGGEVGASMSLLVESAPANR 155
Cdd:cd17365 49 IGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--------VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 156 RGFYSSWSLATQGLATTFGGIVALGLsawlpfatgsetvMAEWGWRVPFFIGVLLAPIGcwlrlslendapevankksaa 235
Cdd:cd17365 121 RSLAVTLMFCGYPLGAALGGFLAAAL-------------IPAFGWRSVFLLGGVPPLIL--------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 236 asestfslllqhkATLANGVLLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITF---VGALLVGMLCDSV 312
Cdd:cd17365 167 -------------LPLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIggvIGSLLLGWLADRF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 313 GRKKLILISRVMVLLCscpSFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRALGFAlvYSIGVAIFG 392
Cdd:cd17365 234 GPKRVLALFFALGAVS---LALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVG--WALGVGRLG 308
|
...
gi 446047593 393 GFA 395
Cdd:cd17365 309 AIL 311
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
57-377 |
5.42e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 60.66 E-value: 5.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 57 NVALLLAFATFGVSFFMrplggIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAA 136
Cdd:cd17474 35 QVGLLITAFTLPAAVLM-----PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF--------ALLLAGRALQGIGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 137 GGEVGASMSLLVESAPANRRGFYsswsLATQGLATTFGGIVALGLSAWLpfatgsetvmAEWGWRVPFFIGVLLAPIGCW 216
Cdd:cd17474 102 AGLGPLALTLIGDLFEGGERAKA----MGLYEAALGLGIAVGPLLGGLL----------AAISWRYPFFLLAALIPVAFL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 217 LRLSLENDAPEVANKKSAAAsestfslLLQHKATLANGVLLAIGSTVATYISLFY-YGTWAAKYLAMPQHYSH----AAM 291
Cdd:cd17474 168 AILFLLPEPKEKAKSSSATK-------LRDLKKALRGRGLLTFLVSAFLYFFLYFaFLTYLPFLLELLYGISPiiigLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 292 LLAGVITFVGALLVGMLcdsVGRKKLILISRVMVLLCSCPSFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELL 371
Cdd:cd17474 241 AGWSVLLALGSLFVGRL---LKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
....*.
gi 446047593 372 PKRIRA 377
Cdd:cd17474 318 PEEERG 323
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
76-383 |
6.44e-10 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 60.73 E-value: 6.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 76 LGGIIVGAWADRFGRKPAMVFTIALMslgtlMIGIAPTYATAGYWgtATLVLARLIQGVAAGGEVGASMSLLVESAPANR 155
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQIGCVIY-----IIGAIIQVAAIGKW--YQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 156 RGFYSSwslaTQGLATTFGGIVAlglsAWLPFATgsETVMAEWGWRVPFFIGV---LLAPIGCWLrlslendapevankk 232
Cdd:cd17356 133 RGTLVS----LYQLAITIGILVA----YCINYGT--HKLDGSAQWRIPLGLQIvwgLLLLIGMFF--------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 233 saaASESTFSLLlqhKATLANGVLLAIGSTVATYIslFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSV 312
Cdd:cd17356 188 ---LPESPRWLY---RTILGIMLQLFQQLTGINYF--FYYGTTIFQSTGLTGSSPLLTSIILYIVNFVSTIPGLFFVDKF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 313 GRKKLILISRVMVLLC-----------SCPSFWLLVNYPSPG---MLLTVVFVMVSFTTLGGVPVMlLISELLPKRIRAL 378
Cdd:cd17356 260 GRRTCLLIGAAGMSIClfiyaavgvryLIPNPQSGTSNKSAGngmIVFICLFIFSFATTWGPIAWV-YVAEVFPLRVRSK 338
|
....*
gi 446047593 379 GFALV 383
Cdd:cd17356 339 GMALA 343
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
79-430 |
6.49e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 60.65 E-value: 6.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 79 IIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTyatagywgTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGF 158
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 159 YSSWSLATQGLATTFGGIVALGLSAWLpfatgsetvmaewGWRVPFFIGVLLAPIGcwlrlslendapevankksaaase 238
Cdd:cd17321 121 ALGLWGAVVGIGAALGPLLGGLLLELF-------------GWRWIFLINVPIGLVA------------------------ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 239 stfsLLLQHKATLANGVLLAIGSTVATYisLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLI 318
Cdd:cd17321 164 ----LLLARTFSGAVLAAFLLGAALGGL--LFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 319 LISRVMVLLCSCPSFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKR----------IRALGFALVYSIGV 388
Cdd:cd17321 238 VAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKagaasgilntARQLGGALGVALLG 317
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446047593 389 AIFGGFAQYFATQSIVLLESLTAPAWYLGGGTLLSMLALLFV 430
Cdd:cd17321 318 ALLTAGLSANLGDSGVAALLSAAAAAFAAGFHLAFLVAAALA 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
67-428 |
9.19e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 60.13 E-value: 9.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 67 FGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASMSL 146
Cdd:cd06174 37 FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 147 LVESAPANRRGFYSSWSLATQGLATTFGGIVALGLSAWLpfatgsetvmaEWGWRVPFFIGVLLAPIGCWLRLSLENDAP 226
Cdd:cd06174 109 IADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-----------GFGWRAVFLIAAALALLAAILLLLVVPDPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 227 EVANKKSAAASESTFSLLLQHKATLANGVLLAIGST---VATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGAL 303
Cdd:cd06174 178 ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFlvnLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 304 LVGMLCD-SVGRKKLILISRVMVLLCSCPSFWLLVNYPSPGMLLTVVFVMVSFTTLGgvpvMLLISELLPKRIRALGFAL 382
Cdd:cd06174 258 LLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLS----FALIAELFPPEIRGTAFGL 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446047593 383 VYSIGvAIFGGFAQYFATQSIVLLESLTAPAWYLGGGTLLSMLALL 428
Cdd:cd06174 334 LNTFG-FLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
49-430 |
1.60e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 59.12 E-value: 1.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 49 FFPPSADHNVALLLAFATFGVSFFmrplgGIIVGAWADRFGRKPAMVFTIALMSLGtlmiGIAPTYATAGYWgtatLVLA 128
Cdd:cd17473 28 HFVPNSELLVPLLLTLPALFIALF-----APLAGWLADRFGRKRLLIAGLLLYGIG----GVAGLFLDSLYA----LLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 129 RLIQGVAAGGEVGASMSLLVESAPANRRgfySSWsLATQGLATTFGGIVALGLSAWLpfatgsetvmAEWGWRVPFFI-- 206
Cdd:cd17473 95 RALLGIGVAGIMTLATALIGDYFEGEER---AKM-LGLQSAAMSLGGVVFLLLGGAL----------AEIGWRAPFLVyl 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 207 --GVLLAPIGCWLRLSLENDAPEVANKKSAAASESTFSLLLQHKATLANGVLLaigSTVATYISLFyygtWAAKYLAMPQ 284
Cdd:cd17473 161 laLPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLF---YVIPIQLPFL----LQERGGGSAA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 285 HYShAAMLLAGVITFVGALLVGMLCDSVGRKKLILISRVM----VLLCSCPSFWllvnypsPGMLLTVVFVMVSFTTLgg 360
Cdd:cd17473 234 LIG-LALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALmalgFLLLALASGL-------WVVLLGAILAGLGFGLL-- 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446047593 361 VP-VMLLISELLPKRIRALGFALVYSigvAIFGG-FAQYFATQSIVLLESLTAPAWYLGGGTLLSMLALLFV 430
Cdd:cd17473 304 LPtLNSWAMSLVPPELRGRAMGIVTS---AFFLGqFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
20-382 |
2.03e-09 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 59.28 E-value: 2.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 20 VIFASAFGNALEFFDFGVYNFFVVYISTLFFPPSADHNVALLLAFATFGVSFFMRPL-GGIIVGAWADRFGRKPAMVFTI 98
Cdd:TIGR00879 29 LSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFiGALFAGWLSDRFGRKKSLLIIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 99 ALMSLGTLMIGiaptyATAGYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSlatqGLATTFGGIVA 178
Cdd:TIGR00879 109 LLFVIGAILMG-----LAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLY----QLAITFGILVA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 179 LGLSAWLPFATGSE----TVMAEWGWRVPFFIGVLLAP-----------------IGCWLRLSLENDAPEVANK------ 231
Cdd:TIGR00879 180 YGFGSGKVSLNNTLgwriPLGLQLIPAGLLFLGLFFLPesprwlvgkgrveearkSLARLRGTSGEDKELLDELelidik 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 232 ------KSAAASESTFSLLLQHKATLANGVLLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLV 305
Cdd:TIGR00879 260 rsiekrSVQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFAFTFVA 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 306 GMLCDSVGRKKLILISRV-----MVLLCSCPSFWLLVNYPSPGMLLTVVFVMVSF---TTLGGVPVMlLISELLPKRIRA 377
Cdd:TIGR00879 340 IFLVDRFGRRPLLLIGAAgmaicLFVLGILGASFVTGSSKSSGNVAIVFILLFIAffaMGWGPVPWV-IVSEIFPLSLRP 418
|
....*
gi 446047593 378 LGFAL 382
Cdd:TIGR00879 419 KGISI 423
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
75-430 |
2.17e-09 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 59.13 E-value: 2.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 75 PLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPtyatagywGTATLVLARLIQGVAAGGEVGASMSLLVESAPAN 154
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAK--------DVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 155 RRGfysSWSLATQgLATTFGGIVALGLSAWLPFATgseTVMAEWGWRVPFFIGVL--------LAPIG---------CWL 217
Cdd:cd17358 127 VRG---ALGSLNQ-LLVNIGILLGYVLGSFLPWRT---LALIGAIPPVVFLILLFfipesprwLAKKGreeeaekslQFL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 218 RLSLENDAPEVA------NKKSAAASESTFSLLLQHKAtlANGVLLAIGSTVA-----TYISLFYYGTWAAKylAMPQHY 286
Cdd:cd17358 200 RGKDADISKEAAeiqeelAELEKEAKESSFSDLFQRKY--LKPLVIGLGLMLFqqlsgINAVIFYASSIFDE--AGSGLD 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 287 SHAAMLLAGVITFVGALLVGMLCDSVGRKKLILISRVMVLLCS--------CPSFWLLVNYPSPGMLLTVVFVMVSFTT- 357
Cdd:cd17358 276 PNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLlalglyfyLQEHGALLSSVSWLPLVGLVIYIISFSIg 355
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446047593 358 LGGVPvMLLISELLPKRIRALGFALVysIGVAIFGGFAQYFATQSIVLLESLTAPAWYLGGgtlLSMLALLFV 430
Cdd:cd17358 356 LGPLP-WVIMSEIFPAKIKGLAGSLV--TLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAG---ICGLALVFV 422
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
57-406 |
5.36e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.60 E-value: 5.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 57 NVALLLAFATFGVSFFMRPLggiiVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPtyatagywGTATLVLARLIQGVAA 136
Cdd:cd17489 31 AVAGLVVGLFTLAALLARPF----AGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--------SVALLLVLRLIHGIGW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 137 GGEVGASMSLLVESAPANRRGFYSSWSLATQGLATTFGGIVALGLSAWlpfatgsetvmaeWGWRVPFFIGVLLAPIGCW 216
Cdd:cd17489 99 GAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQH-------------LGFAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 217 LRLSLEndAPEVANKKSAAASESTFSLLLQHKATLANGVLLAIG---STVATYISLFyygtwaakylAMPQHYSHAA--M 291
Cdd:cd17489 166 LVFLVK--DPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASiayGAISTFLPLY----------AAERGISNAGlfF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 292 LLAGVITFVGALLVGMLCDSVGRKKLILISRVMVLLcscpSFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELL 371
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLAL----GLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLV 309
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446047593 372 PKRIRA-------LGFALVYSIGVAIFGGFAQYFATQSIVLL 406
Cdd:cd17489 310 PPHRRGaangtffIFFDLGIGLGGLLLGLVAELFGYRAMFLL 351
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
80-412 |
2.92e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 55.27 E-value: 2.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 80 IVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYATagywgtatLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFy 159
Cdd:cd17503 50 LSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGA- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 160 sswSLATQGLATTFGGIVALGLSAWLpfatgsetvMAEWGWRVPFFIGVLLAPIGCW----LRLSlendapevankksaa 235
Cdd:cd17503 121 ---AMGLVGLVILLAPAIGPTLGGWL---------TDNLSWRWIFYINLPIGILALLlaplLDLR--------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 236 asestfslLLQHKaTLANGVLLAIGSTVATYISLFYYGTwaakYLAMPQHYS--HAAMLLA--GVITFVGALLVGMLCDS 311
Cdd:cd17503 174 --------LFKDR-NFTLGLLLSFLLGLGLFGAMFLLPL----YLQNVLGYSafESGLVLApgGLASAILSPLVGRLLDK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 312 VGRKKLILISRVMVLLCSCPSFWLLVNYPSPgMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRALGFALVY------- 384
Cdd:cd17503 241 FGPRLLLLAGLLLLALGTLLLAFLTPDTSLW-LIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNtirqlgg 319
|
330 340
....*....|....*....|....*...
gi 446047593 385 SIGVAIFGGFAQYFATQSIVLLESLTAP 412
Cdd:cd17503 320 SIGTALLATLLTNRTQFHHSRLSELLAQ 347
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
61-402 |
3.28e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 55.25 E-value: 3.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 61 LLAFATFGVSFFMRPLggiiVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYATAGywgtATLVLARLiqGVAAGGEV 140
Cdd:cd17478 35 LLVSVFSITSSLLQPL----FGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLL----LLVALAGI--GSAAFHPE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 141 GASMsllVESAPANRRGFYSSWSLATQGLATTFGGIVALGLsawlpfatgsetvMAEWGWRVPFFIGVLLAPIGCWLRLS 220
Cdd:cd17478 105 GARL---ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAAL-------------VALFGGLGLLILLIIPGLAVALLLLR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 221 LENDAPEVANKKSAAASESTFSLLLQHKATLANGVLLA---IGSTVATYISLFY----YGTWAAKYLAmpqhyshAAMLL 293
Cdd:cd17478 169 LRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLrswVLSSLTTFLPFYLvqrgYSLVFAGLLL-------SLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 294 AGVItfvGALLVGMLCDSVGRKKLILISrvmvLLCSCPSFWLLVNypSPGMLLTVVFVMVSFTTLGGVPVMLLIS-ELLP 372
Cdd:cd17478 242 AGAI---GTLIGGPLSDRFGRRRVIIAS----LLLAAPFLLLFLL--TPGIWSYILLVLAGFLLFASFPVTVVLAqELLP 312
|
330 340 350
....*....|....*....|....*....|....*.
gi 446047593 373 KRIRA-----LGFAL-VYSIGVAIFGGFAQYFATQS 402
Cdd:cd17478 313 GNVGLasglmMGLSFgLGGIGAPVLGALADAFGLES 348
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
62-430 |
1.25e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 53.34 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 62 LAFATFGVSFFmrpLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAptyatagyWGTATLVLARLIQGVAAGGEVG 141
Cdd:cd17319 42 LIASAFFLGYA---LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA--------TSLTSLYVLRFLLGVAEAGFFP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 142 ASMSLLVESAPANRRGFYSSWSLATQGLATTFGGIvalgLSAWLpfatgsetvMAEWGWRVPFFI----GVLLAPIgcWL 217
Cdd:cd17319 111 GAIKALAEWFPARERGRATGLFNSGAPLGAAIGPP----LSGWL---------LLLFGWRWAFIIegllGLLLAVL--WW 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 218 RLslendapevankksaaasestfslllqhkatLANGVLLAIGsTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVI 297
Cdd:cd17319 176 FY-------------------------------LRQVWGLALG-YFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 298 TFVGAlLVGMLCDSVGRKKLILISRVMV----LLCSCPSFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPK 373
Cdd:cd17319 224 PFLAG-AIGMILGGRLSDRLLRGARRLViiigLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPG 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446047593 374 RIRALGFALVYSIGvAIFGGFAQYFATQSIVLLESLTAPAWYLGGGTLLSMLALLFV 430
Cdd:cd17319 303 EAAATAGGLINSGG-NLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
24-430 |
1.30e-07 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 53.51 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 24 SAFGNALEFFDFGVYNFFVVYISTLFFPPSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIALMSL 103
Cdd:cd17362 2 PALGGLLFGYDIGATSGALLSITSPALSGTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 104 GTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFysswsLATQGLATTFGGIValglsa 183
Cdd:cd17362 82 GSLVTGLAPSY--------PVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGL-----LVSLKELFIVLGIL------ 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 184 wLPFATGSETVMAEWGWRVPFFIGVLLAPI-GCWLRLSLENDAPEVANKKSAAASestFSLLLQHKATLANGVLLAIGST 262
Cdd:cd17362 143 -LGYVSGYAFADVVGGWRYMYGLAAPPALLlGIGMWFLPPSPRWQGNYRKPLIIG---LGLVLFQQITGQPSVLYYAATI 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 263 vatyislFYYGTWAAKYLAMpqhyshAAMLLAGVITFVGALLVGMLCDSVGRKKLILIS-RVMVL----LCSCPSFWLLV 337
Cdd:cd17362 219 -------FKSAGFSAASDAT------LVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGvSGMVVslflLAAYNLFVQMG 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 338 NYPSPGMLLTVVFVMVSFTTLGGVPVM-LLISELLPKRIRALGFALVYSIGVAIFGGFAQYFATqsivLLESLTAPAWYL 416
Cdd:cd17362 286 PAGLAWLSLVALLLYVGAYQISFGPISwLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLP----LQELIGLPGTFL 361
|
410
....*....|....
gi 446047593 417 GGGtLLSMLALLFV 430
Cdd:cd17362 362 GFG-VIGVLALLFI 374
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
41-430 |
1.20e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 50.35 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 41 FVVYISTLFFPPSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYAtagyw 120
Cdd:cd17355 18 IRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLW----- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 121 gtATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGfyssWSLATQGLATTFGGIVALGLSAWLPFATGSETVMAEWGw 200
Cdd:cd17355 93 --QLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRG----LALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLA- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 201 rvpFFIGVLLAPIGCWLRLSLENDAPEVANKKSAAASESTFSLLLQHKATlangVLLAIGSTVATYISLFYYGTWAAKYL 280
Cdd:cd17355 166 ---LLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASF----WLLALAFFLCGFAVVGLIVHLVPYLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 281 AMPQHYSHAAMLLA--GVITFVGALLVGMLCDSVGRKKLILISRVMVLLCSCpsFWLLVNYPSPGMLLTVVFVMVSFTTL 358
Cdd:cd17355 239 DRGISPAAAAVALAliGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLA--LLLLLPFPPLALLLFAALFGLGWGAT 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446047593 359 GGVPVMLLISELLPKR------IRALGFALVYSIGVAIFGGFAQYFATqsivlleslTAPAWYLGGGTLLSMLALLFV 430
Cdd:cd17355 317 VPLTAALAARYFGARSygtlfgLVFAPHQLGSALGPWLGGLLYDRTGS---------YTAAWALAVALGLIAALLVLP 385
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
76-351 |
1.96e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 49.87 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 76 LGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPtyatagywGTATLVLARLIQGVAAGGEVGASMSLLVESAPaNR 155
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP--------SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 156 RGFYSSWSLATQGLattfGGIVALGLSAWLpfatgsetvMAEWGWRVPFFIGVLLAPIG--CWLRLSLENDAPEvankkS 233
Cdd:COG2807 139 VGLMTGLYTAAMGL----GAALAAGLTVPL---------AAALGWRGALAVWALLALLAllLWLPLLRRRPAAA-----A 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 234 AAASESTFSLLLQHKATLAngVLLAIGSTVATYISLFyygTWAAKYLA---MPQHYSHAAMLLAGVITFVGALLVGMLCD 310
Cdd:COG2807 201 AAPAAASLRSLWRSPLAWL--LTLFFGLQSLLYYAVV---AWLPPILRdagLSAATAGLLLSLFQLAGIPGSLLVPLLAD 275
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 446047593 311 SVGRKKLILisrVMVLLCSCPSFWLLVNYPSPGMLLTVVFV 351
Cdd:COG2807 276 RLGDRRPLL---LLLGLLGLAGLLGLLLAPGSLPWLWAVLL 313
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
64-211 |
3.69e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.49 E-value: 3.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 64 FATFGVSFFmrpLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGAS 143
Cdd:TIGR00880 4 LAGYALGQL---IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNI--------TVLIIARFLQGFGAAFALVAG 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446047593 144 MSLLVESAPANRRGFysswSLATQGLATTFGGIVALGLSAWLpfatgsetvMAEWGWRVPFFIGVLLA 211
Cdd:TIGR00880 73 AALIADIYPPEERGV----ALGLMSAGIALGPLLGPPLGGVL---------AQFLGWRAPFLFLAILA 127
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
80-404 |
7.69e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 47.56 E-value: 7.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 80 IVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTyatagywgTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFY 159
Cdd:cd17502 49 IYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPN--------MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 160 SSWSLATQGLATTFGGIVAlGLsawlpFATGsetvmaeWGWRVPFFIGVllaPIGCWlrlslendapevankksAAASES 239
Cdd:cd17502 121 QGYIGAVFGIASVAGPLIG-GA-----FTDH-------LSWRWCFYINL---PIGGL-----------------ALALLR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 240 TFSLLLqhkatLANGVLLAIGSTVATYISLFYYGTWAAKYLampqhySHAAMLLAGVITFV-GALLVGMLCDSVGR-KKL 317
Cdd:cd17502 168 TILLSS-----IFGFLFGGALFGLIYYLPLYFQLVLGDSAT------KSGVRLLPLIIGLViGSIISGALISKTGRyKPL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 318 ILISRVMVLLCScpSFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLL-ISELLPKRIRALGFALVY---SIGVAIFGG 393
Cdd:cd17502 237 IVIGTILMSVGA--GLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVaVQNAVPPADVGVATATNTffrSLGGTLGVA 314
|
330
....*....|.
gi 446047593 394 FAQYFATQSIV 404
Cdd:cd17502 315 ITDVFLVALAL 325
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
76-383 |
1.22e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 47.32 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 76 LGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagYWgtatLVLARLIQGVAAGGEVGASMSLLVESAPanr 155
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY----TV----FLVFRLLVGMGIGGIWVQAVVLNTEFLP--- 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 156 rgfySSWSLATQGLATTF--GGIVALGLSAWLpfatgsetvMAEWGW-----RVPFFIGVLLAPIGC----WLRLSLEND 224
Cdd:TIGR00898 211 ----KKQRAIVGTLIQVFfsLGLVLLPLVAYF---------IPDWRWlqlavSLPTFLFFLLSWFVPesprWLISQGRIE 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 225 APE-----VANKKSAAASESTFSLLLQHKATLANG--------------VLLAIGSTVATYISLFYYGTwaakYLAMPQH 285
Cdd:TIGR00898 278 EALkilqrIAKINGKKLPAEVLSLSLEKDLSSSKKqysfldlfrtpnlrKTTLCLMMLWFTTAFSYYGL----VLDLGNL 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 286 YSHAAMLLA--GVITFVGALLVGMLCDSVGRKKLILISRVMVLLCSCPSFWLLVNYPSpgMLLTVVFVMVSFTTLGGVPV 363
Cdd:TIGR00898 354 GGNIYLDLFisGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYF--LRTALAVLGKFGITSAFQMV 431
|
330 340
....*....|....*....|
gi 446047593 364 MLLISELLPKRIRALGFALV 383
Cdd:TIGR00898 432 YLYTAELYPTVVRNLGVGVC 451
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
76-429 |
1.72e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 76 LGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYATAGYWgtaTLVLARLIQGVAAGGEVGASMSLLVESAPANR 155
Cdd:cd06173 49 LFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLW---LLLVLAFLLGIASAFFGPARQALLPELVPKEQ 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 156 RGFYSSWSLATQGLATTFGGIVALGLSAWLpfatgsetvmaewGWRVPFFIGVLLAPIGCWLRLSLENDAPEVANKKSAA 235
Cdd:cd06173 126 LVRANALNSLATQLARIIGPALGGLLVALL-------------GPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 236 ASESTFSLLLqhKATLANGVLLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSV-GR 314
Cdd:cd06173 193 LLRDLREGLR--YLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLsKR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 315 KKLILISRVMVLLCSCPSFWLLVNyPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRalgfALVYSIGVAIFGGF 394
Cdd:cd06173 271 RRRGRLLLIGALLLGLALLVLGLS-PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELR----GRVFSVYNALNSGA 345
|
330 340 350
....*....|....*....|....*....|....*
gi 446047593 395 AQYFATQSIVLLESLTAPAWYLGGGTLLSMLALLF 429
Cdd:cd06173 346 MPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
65-225 |
2.20e-05 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 46.65 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 65 ATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYATAGYwgTATLVLARLIQGVAAGGEVGASM 144
Cdd:TIGR00887 60 AVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSV--MATLCFWRFWLGVGIGGDYPLSA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 145 SLLVESAPANRRGFYSSWSLATQGLATTFGGIVALGLSA----------WLPFATGSETVMAEWGWRVPFFIGVLLAPIG 214
Cdd:TIGR00887 138 IITSEFATKKWRGAMMAAVFAMQGFGILAGAIVALIVLAgfkhsleaaaDEASCTGSCVPAVDYMWRILIGFGAVPALLA 217
|
170
....*....|.
gi 446047593 215 CWLRLSLENDA 225
Cdd:TIGR00887 218 LYFRLTIPETP 228
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
76-379 |
4.53e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 45.34 E-value: 4.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 76 LGGIIVGAW-ADRFGRKPAMVFTIALMSLGTLmigiaptyATAGYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPAN 154
Cdd:PRK11551 64 LPGALLGGRlADRIGRKRILIVSVALFGLFSL--------ATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPR 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 155 RRGfySSWSLATQGLAttFGGIVALGLSAWLPFATgsetvmaewGWRVPFFIG----VLLAPIgcwLRLSLENDAPEVAN 230
Cdd:PRK11551 136 LRG--TAVSLMYCGVP--FGGALASVIGVLAAGDA---------AWRHIFYVGgvgpLLLVPL---LMRWLPESRAFAQA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 231 KKSAAASESTFSLLLQHKATLANgVLLAIgSTVATYISLFYYGTW-----AAKYLAMPQhySHAAMLLAGVITFVGALLV 305
Cdd:PRK11551 200 AGAGKQRAPVLRALFGEGRATAT-LLLWI-SYFFTLIVLYFLLNWlpsllVGQGLSRSQ--AGLVQIAFNIGGALGSLLI 275
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446047593 306 GMLCDSVGRKKLILIsrvmVLLCSCPSFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRALG 379
Cdd:PRK11551 276 GALMDRLRPRRVVLL----IYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTG 345
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
80-431 |
5.43e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 45.26 E-value: 5.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 80 IVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVaAGGEVGASMSLLVESAPANRRGFY 159
Cdd:cd17504 50 ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNL--------PVLIAGRALQGI-GGAVFPLAFALVREEFPPERVPVA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 160 SSWslatqgLATTFGGIVALGLsawlpFATGseTVMAEWGWRVPFFIGVLLAPIGCWLrlslendAPEVANKksaaases 239
Cdd:cd17504 121 QGI------LSATFGIGAGIGL-----PLGG--WIVQHLGWRWIFWTAAPVAVLLAAL-------VPLIDLR-------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 240 tfslLLQHKATL---ANGVLLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKK 316
Cdd:cd17504 173 ----LLRRRNVLlanITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRR 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 317 LILISRVMVLLCSCpsfWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKR-----------IRALGFALVYS 385
Cdd:cd17504 249 VLLIGLVISAVGLL---LLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDrtgiatgmntvLRTIGSAIGPA 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446047593 386 IGVAIFGGFAQYFATQSIVLLESLTAPAWYLGGGTLLSMLALLFVK 431
Cdd:cd17504 326 IAGAILTTYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
61-393 |
8.42e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.46 E-value: 8.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 61 LLAFATFGVSFFMrplgGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGeV 140
Cdd:COG0738 47 LLLFAFFLGYLLA----SLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLGLGL-L 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 141 GASMSLLVESAPANRRGFYSSWSLATQGLATTFGGIVALGLSAWlpfatgseTVMAEWGWRVPFFIGVLLAPIGCWLRLS 220
Cdd:COG0738 114 DVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILL--------GLSLSWHLPYLILAVLLLLLALLFLRSK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 221 LENDAPEVANKKSAAASestFSLLLQHKATLAngVLLAIGSTVATYISLfyyGTWAAKYLAMPQHYSHA----AMLLAGV 296
Cdd:COG0738 186 LPEIEEEEEEAAGSAAS---LKSLLKNPRLLL--GGLAIFLYVGAEGAI---GDWLPLYLKDVLGLSEAtaalGLSLFWG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 297 ITFVGALLVGMLCDSVGRKKLILISRVMVLLCScpsfwLLVNYPSPGMLLTVVFVMVSFTTLGGVPVML-LISELLPKRI 375
Cdd:COG0738 258 GMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL-----LLALLAPGPWLALIGLALVGLGLSLMFPTIFsLALDGLGKRT 332
|
330
....*....|....*...
gi 446047593 376 RALGFALvysIGVAIFGG 393
Cdd:COG0738 333 AAAVSAV---LIMGIVGG 347
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
64-383 |
8.80e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.49 E-value: 8.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 64 FATFGVSFFM--RPLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVG 141
Cdd:cd17317 26 LVALVQTIFFlgVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSY--------ELFLVLRFLVGVTSAGIFT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 142 ASMSLLVESAPANRRgfysSWSLATQGLATTFGGIVALGLSAWLPfatgsetvmaewGWRVPFFI----GVLLAPIGCWL 217
Cdd:cd17317 98 VGFVLGMEIVGPKYR----SFVGILFGLFWALGYMLLALLAYLIR------------DWRWLQLAislpGLLFLLLLWWL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 218 rlslendapevankksaaasestfslllqHKATLANGVLLAIGSTVATYISLFYYGTWAAKYLampqhyshaAMLLAGVI 297
Cdd:cd17317 162 -----------------------------PRRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYL---------NFFLSGLV 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 298 TFVGALLVGMLCDSVGRKKLILISRVMVLLCSCPSFWLLVNYPSpgmlLTVVFVMVSFTTLGGVPVMLLI--SELLPKRI 375
Cdd:cd17317 204 EIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENT----LALTLALVGKFAISAAFSVIYLytAELYPTVV 279
|
....*...
gi 446047593 376 RALGFALV 383
Cdd:cd17317 280 RNTGVGLC 287
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
23-379 |
1.19e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 44.18 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 23 ASAFGNALEFFDFGVYNFFVVYISTLFFPPSADHNVALLLAFATFGVSFfmrpLGGIIVGAWADRFGRKPAMVFTIALMS 102
Cdd:cd17360 1 FAGIGGFLFGYDTGVISGALLYIKDDLGEVVLSTGWQELIVSSTVAGAA----VGAAIGGWLNDRFGRRPCILLADALFT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 103 LGTLMIGIAPTYatagywgtATLVLARLIQGVAAGgevGASMS---LLVESAPANRRGFYsswsLATQGLATTFGGIVAL 179
Cdd:cd17360 77 IGAIVMAAAPNK--------EVLIVGRVLVGLGVG---IASMTvplYIAEAAPPRIRGRL----VTINVLFITGGQFVAY 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 180 GLSAWLPFATGsetvmaewGWRVPFFIGVLLAPIGCWLRLSLENDAPEVANKKSaaasestfslllqhkatLANGVLLAI 259
Cdd:cd17360 142 VINGAFSYLPG--------GWRWMLGLAAVPAVLQFIGLLFLPESPRWPSTRRA-----------------LIVGCGLQA 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 260 GSTVATYISLFYYgtwAAKYLAMPQ-HYSHAAMLLAGVITFVGAL--LVGMLC-DSVGRKKLILISRVMVLLCscpsfwL 335
Cdd:cd17360 197 FQQFSGINTVMYY---SATILQMAGfKDNQNAIWLSLIVAGTNFIftIVGMYLiDKFGRRKLLLISLFGVIVA------L 267
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 446047593 336 LVNYPSPGMLLTVVFVMVSFTTLGGVPvMLLISELLPKRIRALG 379
Cdd:cd17360 268 VVLAVWLALVGLILYLAFFAPGMGPVP-WTVNSEIYPLWARGTG 310
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
65-309 |
1.20e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.10 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 65 ATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASM 144
Cdd:cd17320 38 LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSI--------EQLLIARFLQGLGAAAGSVVAR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 145 SLLVESAPANRRGFYsswsLATQGLATTFGGIVALGLSAWLpfatgsetvMAEWGWRVPF-FIGVLLAPIGCWLRLSLEN 223
Cdd:cd17320 110 AIVRDLYSGAELAKI----FSLLMMILAIAPALAPLLGGLL---------LLFFGWRAIFvFLALLGLLLLLLVLLFLPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 224 DAPEVANKKSAAASESTFSLLLQHKATLANGVLLAIGSTvatyiSLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGAL 303
Cdd:cd17320 177 TLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFA-----GLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALI 251
|
....*.
gi 446047593 304 LVGMLC 309
Cdd:cd17320 252 LGSLLN 257
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
299-437 |
3.17e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.08 E-value: 3.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 299 FVGALLVGMLCDSVGRKKLILISRVMVLLcscpSFWLLVNYPSPGMLLtVVFVMVSFTTLGGVPV-MLLISELLPKRIRA 377
Cdd:TIGR00898 141 LLGSFVFGYLSDRFGRKKVLLLSTLVTAV----SGVLTAFSPNYTVFL-VFRLLVGMGIGGIWVQaVVLNTEFLPKKQRA 215
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446047593 378 ----LGFaLVYSIGVAIFGGFAqYFATQSIVLLESLTAPawylgggTLLSMLALLFVKEPAKEL 437
Cdd:TIGR00898 216 ivgtLIQ-VFFSLGLVLLPLVA-YFIPDWRWLQLAVSLP-------TFLFFLLSWFVPESPRWL 270
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
80-214 |
4.43e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 42.37 E-value: 4.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 80 IVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYATagywgtatLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFy 159
Cdd:TIGR00711 56 LTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLEL--------MIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGR- 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 446047593 160 sswSLATQGLATTFGGIVALGLSAWLpfatgsetvMAEWGWRVPFFIGVllaPIG 214
Cdd:TIGR00711 127 ---AMAIWGLTVLVAPALGPTLGGWI---------IENYHWRWIFLINV---PIG 166
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
82-421 |
4.66e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 42.20 E-value: 4.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 82 GAWADRFGRKPAMVFTIALMSLGTLmigIApTYATAGYWgtatLVLARLIQGvaAGGEVGASMSLLVESAPANRRgfyss 161
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSL---LA-AYATSIYG----LILGRALQG--SGAISSVVMALLADLTREENR----- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 162 wslatqGLATTFGGIVaLGLSAWLPFATGSEtVMAEWGWRVPFFIGVLLApIGCWLRLSLENDAPEVANKKSAAASESTF 241
Cdd:cd17472 118 ------TKAMALIGAS-IGIAFAISMVLGPL-LAAHLGVSGLFLITAILS-LVSLLILLFFVPDPPKIVQISEKEKKKLK 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 242 SLLLQHKATLANgvlLAIGSTVATYISLFYYGTWAAKYLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILIS 321
Cdd:cd17472 189 KLLKNKRLLRLD---FSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 322 RVMVLLCSCPSFWLLVNYPSPGMLLTVVFvMVSFTTLGGVpVMLLISELLPKRIRALGFALVYS-------IGVAIFGGF 394
Cdd:cd17472 266 SILLIAVGFLLLLFAATSLWLLIIGLIIF-FIGFNLLEAL-LPSLVSKIAPKEYRGTAMGIYNTsqflgsfLGGALGGLL 343
|
330 340
....*....|....*....|....*..
gi 446047593 395 AQYFATQSIVLLESLTAPAWYLGGGTL 421
Cdd:cd17472 344 WGLLGYSSVFLTILILALLWLLVSFLL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-172 |
7.41e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 7.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 19 RVIFASAFGNALEFFDFGVYNFFVVYISTLFFPPSADHNVALLLAFATFGVsffmrpLGGIIVGAWADRFGRKPAMVFTI 98
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV------LGALLAGRLADRFGRRRLLLIGL 280
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446047593 99 ALMSLGTLMIGIAPTYATagywgtatLVLARLIQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATT 172
Cdd:COG2814 281 LLLALGLLLLALAGSLWL--------LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
76-398 |
8.11e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 41.46 E-value: 8.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 76 LGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTyATAGYWGTATLVLarlIQGVAAGGEVGASMSLLVESAPANR 155
Cdd:cd17345 53 LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPS-ATSSVGLMFILLF---LNGWFQGMGWPPSGRTMVHWFSKKE 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 156 RGFYSS-WSLATQglattFGGIVALGLSAWLPFATGSETVMAEWGwrVPFFIGVLLAPIgCWLRLS-------------L 221
Cdd:cd17345 129 RGTWTSiWNISHN-----VGGGLVGPLAGLGLAIFGDGWWRGAFI--FPAIIAIIVAVI-VLFLGKdtpeseglppieeY 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 222 ENDAPEVANKKSAAASESTFSLLLQHkaTLANGVLLAIgSTVATYISLFYYG--TWAAKYLAMPQHYSHAAMLLAGVI-- 297
Cdd:cd17345 201 KGDYPEEADGEEEEQELSAWEIFVKY--VLKNKLLWYI-AIANVFVYLVRYGilDWAPTYLSEVKGFSKAQAMWAFSLfe 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 298 --TFVGALLVGMLCDSV--GRKKLILISRVMVLLCSCPSFWLLvnyPSPGMLLTVVFVMVSFTTlggVPVMLLisellpk 373
Cdd:cd17345 278 waAIPGTLLAGWLSDKLfkGRRAPTGIIFMILVIVALIVYWLA---PNVLVDLIALIALGFLIY---GPVMLI------- 344
|
330 340
....*....|....*....|....*.
gi 446047593 374 RIRALGFALVYSIGVAI-FGGFAQYF 398
Cdd:cd17345 345 GLQALELVPKKAAGTAAgLTGLFGYL 370
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
40-210 |
8.47e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.48 E-value: 8.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 40 FFVVYISTLffpPSADHNVALLLAFATFGVSFFMRPLGGIIVGAWADRFGRKPAMVFTIALMSLgtLMIGIAptYATAGY 119
Cdd:cd17391 18 FLPLYIEQL---GVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAI--VIGLMA--FVTNVW 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 120 WgtatLVLARLIQGVaAGGEVGASMSLLVESAPANRRGfyssWSLATqgLATTFGGIVALGlsawlPFATGsetVMAEW- 198
Cdd:cd17391 91 Q----LLILRLLQGV-FSGYVPNATALIASQTPKEKSG----WALGT--LSTGVVAGTLIG-----PLLGG---FLADLf 151
|
170
....*....|...
gi 446047593 199 GWRVPFFI-GVLL 210
Cdd:cd17391 152 GIRNVFFItGGLL 164
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
299-437 |
1.87e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 40.32 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 299 FVGALLVGMLCDSVGRKKLILISRVMVLLCSCPSFWLLVnYPSPGMLLTVVFVMVSFTTLGGVPVMLLISELLPKRIRAL 378
Cdd:cd17357 63 AIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKS-AKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGA 141
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446047593 379 gFALVYSIGVAIFGGFAQYFATQSIVLLESLTapaWYLGGGT----LLSMLALLFVKEPAKEL 437
Cdd:cd17357 142 -LGSLTQIGVTLGILLGQVFGLPSVLGTETLW---PYLLFFPgipaLLQLAALPFFPESPKFL 200
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
79-216 |
2.42e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.94 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 79 IIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASMSLLVES-APANRRG 157
Cdd:cd17476 51 LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNF--------IFFIICRALQGLGPAFLLPNAMALLGRTyPPGPRKN 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446047593 158 FYSSWSLATQGLATTFGGIVA--LGLSAWLPFATGSETVMA------EWGWRVPFFIGVLLAPIGCW 216
Cdd:cd17476 123 IVFSLFGATAPLGFALGGVFGglFAQLAWWPWIFWFLAILAaivavaAIFWTSPSFIAVLLAVFLGW 189
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
54-187 |
3.86e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 39.16 E-value: 3.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 54 ADHNVALLLAFAtfgvsfFMRPLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagYWgtatLVLARLIQG 133
Cdd:cd17388 37 ATHYGVLLALYA------LMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTL----WW----LYLGRIIAG 102
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446047593 134 VaAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATTFG---GIVALGLSAWLPF 187
Cdd:cd17388 103 I-TGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGpalGGLLGEISPRAPF 158
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
12-330 |
4.09e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 39.37 E-value: 4.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 12 KKKPSGKRVIFASAFgnalefFDFGVYNFFVVyISTLFFPP--------SADHNVALLLAFATfGVSFFMRPLGGIIVGA 83
Cdd:COG2270 3 AAPKASRREILAWAL------YDWANSAFSTV-ITTFVFPPyftsvaalGDPAAATALWGYAL-AIAGLLVALLAPVLGA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 84 WADRFG-RKPAMVFTIALMSLGTLMIGiaptYATAGYWGTATLVLArlIQGVAAGGEVGASMSLLVESAPANRRGFYSSW 162
Cdd:COG2270 75 IADRSGrKKPFLAFFTLLGVLATAALF----FVAPGGLWLGLLLFV--LANIGFEGSLVFYNAFLPDIATPEEIGRVSGL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 163 SLATQGLattfGGIVALGLSAWLpFATGSETVMAEWGWRVPF---FIGVLLAPIGCWLRLSLENDAPEVANKKSAAASES 239
Cdd:COG2270 149 GWALGYL----GGVLLLLINLAL-FLKPEAFGLPDAGEAVRIsflLTALWWLLFALPLFLFLPERPRPGPAPPRGAVRAG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 240 ------TFSLLLQHKATLAngVLLAIgstvATYI----SLFYYGT-WAAKYLAMPQHYSHAAMLLAGVITFVGALLVGML 308
Cdd:COG2270 224 frelrrTLRELRRYRDLLR--FLLAY----FFYRdgvqTVIAFAGiYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRL 297
|
330 340
....*....|....*....|..
gi 446047593 309 CDSVGRKKLILISrVMVLLCSC 330
Cdd:COG2270 298 DDRIGPKRVILVS-LVIWIVVC 318
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
78-382 |
5.07e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.14 E-value: 5.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 78 GIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagywgtATLVLARLIQGVAAGGEVGASMSLLVESAPANRRG 157
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF--------WQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 158 FysswSLATQGLATTFGGIVAlglsawlpFATGSETVMAEWGWRVPFFI----GVLLAPIgcwLRLSLEnDAPEVANKKS 233
Cdd:cd17328 123 R----ALGVFYFAIPLGSGLG--------YVVGGLVAQATGGWRWAFRVtgvlGVLLAIL---LLLFVR-EPPRGAAEGG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 234 AAASESTFSLLLQHKATLANG--VLLAIGSTVATYISLfYYGTWAAKYLAMPQHYSHA----AMLLAGVIT----FVGAL 303
Cdd:cd17328 187 VMAKSTATSFLADLKALAKNPsfILSTLGFTAVSFVTG-ALAFWAPTFFLRAFGVGDLssadVGLIFGAITciagVLGVL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 304 LVGMLCDSVGRKK---LILISRVMVLLCSCPSFWLLVNYPSPgMLLTVVFVMVS--FTTLGGVPVMLLISELLPKRIRAL 378
Cdd:cd17328 266 LGGILADRLRRKTpraDPLVCAVGLLAAAPFLFLALVLALSN-LLLAWVLLFLGefLLSLNWAPVFAILLYVVIPTRRST 344
|
....
gi 446047593 379 GFAL 382
Cdd:cd17328 345 ASAI 348
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
79-230 |
5.89e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 38.69 E-value: 5.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 79 IIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPtyatagYWGTATLVLARLIQGVAAGGEVGASMSLLVESAPANRRGF 158
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLA------YSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSR 125
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446047593 159 YSSWSLAtqglATTFGGIVALGLSAWLpfatgsetvMAEWGWRVPF-FIGVL-LAPIGCWLRLSLENDAPEVAN 230
Cdd:cd17380 126 AVSIVTA----GSYLGTLLGGLIGPLL---------LEYYGWPSVFyFFGLLgLLWALVWLIYLPPVWAIIVAH 186
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
299-398 |
5.97e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.72 E-value: 5.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 299 FVGALLVGMLCDSVGRKKLILISRVMVLLCS-----CPSFWLlvnypspgMLLTVVFVMVSFTTLGGVPVMLLIsELLPK 373
Cdd:cd17317 39 LIGSLLFGYLADRFGRRPVLLLGLVLQIVCGvlsafSPSYEL--------FLVLRFLVGVTSAGIFTVGFVLGM-EIVGP 109
|
90 100
....*....|....*....|....*...
gi 446047593 374 RIR---ALGFALVYSIGVAIFGGFAQYF 398
Cdd:cd17317 110 KYRsfvGILFGLFWALGYMLLALLAYLI 137
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
76-430 |
6.41e-03 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 38.91 E-value: 6.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 76 LGGIIVGAWADRFGRKPAMVFTIALMslgtLMIGIAPTYATAGYW----GTATLVLA----RLIQGVAAGGEVGASMSLL 147
Cdd:PRK10077 70 IGGALGGYCSNRFGRRDSLKIAAVLF----FISALGSAWPEFGFTsigpDNTGYVPEfviyRIIGGIGVGLASMLSPMYI 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 148 VESAPANRRGFYSSWSlatqGLATTFGGIVALGLSaWLPFATGSETVMAEWGWRVPFFIGVLLAPIGC-----------W 216
Cdd:PRK10077 146 AEIAPAHIRGKLVSFN----QFAIIFGQLVVYFVN-YFIARSGDASWLNTDGWRYMFASEAIPALLFLmllyfvpetprY 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 217 LRLSLENDAPEVANKKSAAASESTfSLLLQHKATLANGV-----LLAIGSTV---ATYISLF----------YYGTWAAK 278
Cdd:PRK10077 221 LMSRGKQEQAEGILRKIMGNTLAT-QALQEIKHSLDHGRktggkLLMFGVGViviGVMLSVFqqfvginvvlYYAPEIFK 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 279 YLAMPQHYSHAAMLLAGVITFVGALLVGMLCDSVGRKKLILI-SRVMVLLCSCPSFWLLVNYPSPGMLLTVVFVMVSFTT 357
Cdd:PRK10077 300 TLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIgALGMAIGMFSLGTAFYTQAPGIVALLSMLFYVAAFAM 379
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446047593 358 LGGVPVMLLISELLPKRIRalGFALvySIGVAiFGGFAQYFATQSIVLLESLTAPAWYLGGG------TLLSMLALLFV 430
Cdd:PRK10077 380 SWGPVCWVLLSEIFPNAIR--GKAL--AIAVA-AQWIANYFVSWTFPMMDKNSWLVAHFHNGfsywiyGCMGVLAALFM 453
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
76-206 |
9.98e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 37.78 E-value: 9.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047593 76 LGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYatagywgTATLVLaRLIQGVAAGGEVGASMSLLVESAPANR 155
Cdd:cd17446 48 VGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSF-------PIYCVF-RFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446047593 156 RGFYSSwslaTQGLATTFGGIVALGLSAWLPfatgsetvmaEWGW-----RVPFFI 206
Cdd:cd17446 120 RAVVGT----LLGYCYTLGQLILAGVAYAIR----------DWRWlqlavSLPFFI 161
|
|
| |
