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Conserved domains on  [gi|446048164|ref|WP_000126019|]
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head-tail connector protein [Escherichia coli]

Protein Classification

head-tail connector protein( domain architecture ID 10169104)

phage gp6-like head-tail connector protein is critical in the assembly of the connector, a specialized phage structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage

Gene Ontology:  GO:0016032
PubMed:  19895817

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
gp6 cd08054
Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage ...
 6-103 9.26e-15

Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. It forms a dodecameric ring structure that comprises the middle ring of the connector, located between the portal protein (attached to the head) and the gp7 ring (attached to the tail). It is a component of the mature phage and the absence of HK97 gp6 results in defective head-tail joining and the absence of mature phage particles. Although the crystal structure of HK97 gp6 shows an unexpected 13-mer ring, the biological form present in the mature phage is believed to be a dodecamer.


:

Pssm-ID: 153446  Cd Length: 91  Bit Score: 63.87  E-value: 9.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446048164   6 TLEEIKAHLRVDHDADDEMLMDKVRQATAVLLAYIqGSRDKVISEDGELIPGealtRMKGAAMRLTGMLYRNPDLAerED 85
Cdd:cd08054    1 TLEEAKAHLRIDHDDDDALIELLIDAAEEYIENYT-GRDLDEQTADAEEVPA----LIKLAVLLLVAHLYENREAV--TD 73

                         90
                 ....*....|....*...
gi 446048164  86 LVQGELPFSVSVLIYDLR 103
Cdd:cd08054   74 VTASELPFGVESLLAPYR 91
 
Name Accession Description Interval E-value
gp6 cd08054
Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage ...
 6-103 9.26e-15

Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. It forms a dodecameric ring structure that comprises the middle ring of the connector, located between the portal protein (attached to the head) and the gp7 ring (attached to the tail). It is a component of the mature phage and the absence of HK97 gp6 results in defective head-tail joining and the absence of mature phage particles. Although the crystal structure of HK97 gp6 shows an unexpected 13-mer ring, the biological form present in the mature phage is believed to be a dodecamer.


Pssm-ID: 153446  Cd Length: 91  Bit Score: 63.87  E-value: 9.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446048164   6 TLEEIKAHLRVDHDADDEMLMDKVRQATAVLLAYIqGSRDKVISEDGELIPGealtRMKGAAMRLTGMLYRNPDLAerED 85
Cdd:cd08054    1 TLEEAKAHLRIDHDDDDALIELLIDAAEEYIENYT-GRDLDEQTADAEEVPA----LIKLAVLLLVAHLYENREAV--TD 73

                         90
                 ....*....|....*...
gi 446048164  86 LVQGELPFSVSVLIYDLR 103
Cdd:cd08054   74 VTASELPFGVESLLAPYR 91
Phage_connect_1 pfam05135
Phage gp6-like head-tail connector protein; This family of proteins contain head-tail ...
 6-77 3.70e-06

Phage gp6-like head-tail connector protein; This family of proteins contain head-tail connector proteins related to gp6 from bacteriophage HK97. A structure of this protein shows similarity to gp15 a well characterized connector component of bacteriophage SPP1.


Pssm-ID: 428326  Cd Length: 93  Bit Score: 41.62  E-value: 3.70e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446048164    6 TLEEIKAHLRVDHDADDEMLMDKVRQATAVLLAYIqgsRDKVISEDGELIPgealTRMKGAAMRLTGMLYRN 77
Cdd:pfam05135   3 TLEDIKTLLGIDDDSDDALLNSYIDAAEEYIENYL---GRSLGDPDAISLP----ADLKYAVLELAVARYNN 67
put_DNA_pack TIGR01560
uncharacterized phage protein (possible DNA packaging); This model describes a small (~ 100 ...
 6-103 4.63e-03

uncharacterized phage protein (possible DNA packaging); This model describes a small (~ 100 amino acids) protein found in phage and in putative prophage regions of a number of bacterial genomes. Members have been annotated in some cases as a possible DNA packaging protein, but the source of this annotation was not traced during construction of this model. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 130623  Cd Length: 91  Bit Score: 33.51  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446048164    6 TLEEIKAHLRVDHDADDEMLMdkvrqatavllAYIQGSRDKVISEDGELIPG--EALTRMKGAAMRLTGMLYRNPDLAER 83
Cdd:TIGR01560   1 TLDEVKLSLRIDHDDDDELIK-----------LMIAAAQDYIQSAIGTGVKDsfDSKPLFKLACIKLVAHYYENRGLYAD 69

                          90       100
                  ....*....|....*....|
gi 446048164   84 EDLVQgeLPFSVSVLIYDLR 103
Cdd:TIGR01560  70 RALVN--VPIMVNALIHQLR 87
 
Name Accession Description Interval E-value
gp6 cd08054
Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage ...
 6-103 9.26e-15

Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. It forms a dodecameric ring structure that comprises the middle ring of the connector, located between the portal protein (attached to the head) and the gp7 ring (attached to the tail). It is a component of the mature phage and the absence of HK97 gp6 results in defective head-tail joining and the absence of mature phage particles. Although the crystal structure of HK97 gp6 shows an unexpected 13-mer ring, the biological form present in the mature phage is believed to be a dodecamer.


Pssm-ID: 153446  Cd Length: 91  Bit Score: 63.87  E-value: 9.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446048164   6 TLEEIKAHLRVDHDADDEMLMDKVRQATAVLLAYIqGSRDKVISEDGELIPGealtRMKGAAMRLTGMLYRNPDLAerED 85
Cdd:cd08054    1 TLEEAKAHLRIDHDDDDALIELLIDAAEEYIENYT-GRDLDEQTADAEEVPA----LIKLAVLLLVAHLYENREAV--TD 73

                         90
                 ....*....|....*...
gi 446048164  86 LVQGELPFSVSVLIYDLR 103
Cdd:cd08054   74 VTASELPFGVESLLAPYR 91
Phage_connect_1 pfam05135
Phage gp6-like head-tail connector protein; This family of proteins contain head-tail ...
 6-77 3.70e-06

Phage gp6-like head-tail connector protein; This family of proteins contain head-tail connector proteins related to gp6 from bacteriophage HK97. A structure of this protein shows similarity to gp15 a well characterized connector component of bacteriophage SPP1.


Pssm-ID: 428326  Cd Length: 93  Bit Score: 41.62  E-value: 3.70e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446048164    6 TLEEIKAHLRVDHDADDEMLMDKVRQATAVLLAYIqgsRDKVISEDGELIPgealTRMKGAAMRLTGMLYRN 77
Cdd:pfam05135   3 TLEDIKTLLGIDDDSDDALLNSYIDAAEEYIENYL---GRSLGDPDAISLP----ADLKYAVLELAVARYNN 67
put_DNA_pack TIGR01560
uncharacterized phage protein (possible DNA packaging); This model describes a small (~ 100 ...
 6-103 4.63e-03

uncharacterized phage protein (possible DNA packaging); This model describes a small (~ 100 amino acids) protein found in phage and in putative prophage regions of a number of bacterial genomes. Members have been annotated in some cases as a possible DNA packaging protein, but the source of this annotation was not traced during construction of this model. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 130623  Cd Length: 91  Bit Score: 33.51  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446048164    6 TLEEIKAHLRVDHDADDEMLMdkvrqatavllAYIQGSRDKVISEDGELIPG--EALTRMKGAAMRLTGMLYRNPDLAER 83
Cdd:TIGR01560   1 TLDEVKLSLRIDHDDDDELIK-----------LMIAAAQDYIQSAIGTGVKDsfDSKPLFKLACIKLVAHYYENRGLYAD 69

                          90       100
                  ....*....|....*....|
gi 446048164   84 EDLVQgeLPFSVSVLIYDLR 103
Cdd:TIGR01560  70 RALVN--VPIMVNALIHQLR 87
phage_chp_gp8 TIGR02215
phage conserved hypothetical protein, phiE125 gp8 family; This model describes a family of ...
 5-38 5.57e-03

phage conserved hypothetical protein, phiE125 gp8 family; This model describes a family of proteins found exclusively in phage or in prophage regions of bacterial genomes, including the phage-like Rhodobacter capsulatus gene transfer agent, which packages DNA. Members of this family show some similarity to members of pfam05135, a putative DNA packaging protein family. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 274035 [Multi-domain]  Cd Length: 188  Bit Score: 34.39  E-value: 5.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 446048164    5 LTLEEIKAHLRVDHDADDEMLMDKVRQATAVLLA 38
Cdd:TIGR02215  14 LTVADFKAHLRLGTEVEDAVLASLLRAARAAIEA 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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