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Conserved domains on  [gi|446058781|ref|WP_000136636|]
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MULTISPECIES: staphyloferrin B ABC transporter permease subunit SirC [Staphylococcus]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 27-327 6.29e-82

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 250.76  E-value: 6.29e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  27 SMMIGSSFIPLQRVLMYFINPN-DSMDQFTLEVLRLPRITLAILAGAALGMSGLMLQNVLKNPIASPDIIGITGGASLSA 105
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDgDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 106 VVFIAFFSHLTIHLLPLFAVLGGAVAMMILLVF-QTKGQIRPTTLIIIGISMQTLFIALVQGLLITTKQLSAAKAYTWLV 184
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLaRRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 185 GSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAISLVGNIGFVGLI 264
Cdd:COG0609  161 GSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLV 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446058781 265 APHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFFIYLLL 327
Cdd:COG0609  241 VPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLR 303
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 27-327 6.29e-82

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 250.76  E-value: 6.29e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  27 SMMIGSSFIPLQRVLMYFINPN-DSMDQFTLEVLRLPRITLAILAGAALGMSGLMLQNVLKNPIASPDIIGITGGASLSA 105
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDgDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 106 VVFIAFFSHLTIHLLPLFAVLGGAVAMMILLVF-QTKGQIRPTTLIIIGISMQTLFIALVQGLLITTKQLSAAKAYTWLV 184
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLaRRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 185 GSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAISLVGNIGFVGLI 264
Cdd:COG0609  161 GSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLV 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446058781 265 APHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFFIYLLL 327
Cdd:COG0609  241 VPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLR 303
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 20-327 4.18e-72

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 225.87  E-value: 4.18e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781   20 LAIVSVVSMMIGSSFIPLQRVLMYFINPNDSMDQFTLEVLRLPRITLAILAGAALGMSGLMLQNVLKNPIASPDIIGITG 99
Cdd:pfam01032   2 LLLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  100 GASLSAVVFIAFFSHLTIHLLPLFAVLGGAVAMMILLVF-QTKGQIRPTTLIIIGISMQTLFIALVQGLLITTKQLSAAK 178
Cdd:pfam01032  82 GAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLsRGRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  179 AYTWLVGSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAISLVGNI 258
Cdd:pfam01032 162 ILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPI 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446058781  259 GFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFFIYLLL 327
Cdd:pfam01032 242 GFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLL 310
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
16-327 2.43e-62

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 209.70  E-value: 2.43e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  16 ALIFLAIVSVVSMMIGSSFIPLQRVLmyfinpnDSMDQFTLEvLRLPRITLAILAGAALGMSGLMLQNVLKNPIASPDII 95
Cdd:PRK10577 361 LGLLLLLALVVALSFGRDAHGWNWLS-------GQLLDALLP-LRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVL 432

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  96 GITGGASLSAVVFIAFFSHLTIHLLPLFAVLGGAVAMMILLVFQTKGQIRPTTLIIIGISMQTLFIALVQgLLITTKQLS 175
Cdd:PRK10577 433 GISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLARRGGFAPERLLLTGIALSALFTALIQ-LLLASGDPR 511

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 176 AAKAYTWLVGSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAISLV 255
Cdd:PRK10577 512 AAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATV 591

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446058781 256 GNIGFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFFIYLLL 327
Cdd:PRK10577 592 GPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLR 663
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 66-326 1.33e-40

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 142.70  E-value: 1.33e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  66 LAILAGAALGMSGLMLQNVLKNPIASPDIIGITGGASLSAVVFIAFFSHLTIHLLPLFAVLGGAVAMMILLVFQTKGQIR 145
Cdd:cd06550    3 AALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGGLS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 146 PTTLIIIGISMQTLFIALVQgLLITTKQLSAAKAYTWLVGSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPV 225
Cdd:cd06550   83 PSKLILIGIVLSAFFSAGVI-LISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 226 AIGLGLHVQRMKLIQLITSTILVSMAISLVGNIGFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFlP 305
Cdd:cd06550  162 AKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL-P 240

                        250       260
                 ....*....|....*....|.
gi 446058781 306 KEVPAGVFIAAFGAPFFIYLL 326
Cdd:cd06550  241 SELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 27-327 6.29e-82

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 250.76  E-value: 6.29e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  27 SMMIGSSFIPLQRVLMYFINPN-DSMDQFTLEVLRLPRITLAILAGAALGMSGLMLQNVLKNPIASPDIIGITGGASLSA 105
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDgDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 106 VVFIAFFSHLTIHLLPLFAVLGGAVAMMILLVF-QTKGQIRPTTLIIIGISMQTLFIALVQGLLITTKQLSAAKAYTWLV 184
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLaRRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 185 GSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAISLVGNIGFVGLI 264
Cdd:COG0609  161 GSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLV 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446058781 265 APHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFFIYLLL 327
Cdd:COG0609  241 VPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLR 303
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 16-327 3.15e-76

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 237.33  E-value: 3.15e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  16 ALIFLAIVSVVSMMIGSSFIPLQRVLMYFINPNDSMDQFTLEVLRLPRITLAILAGAALGMSGLMLQNVLKNPIASPDII 95
Cdd:COG4779   29 LLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDPGASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPDII 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  96 GITGGASLSAVVFIAFFsHLTIHLLPLFAVLGGAVAMMILLVFQTKGQIRPTTLIIIGISMQTLFIALVQGLLITTKQLS 175
Cdd:COG4779  109 GITAGASAGAVAAIVVL-GGSGLAVALGALAGGLATALLVYLLAWRGGVSGYRLILVGIGVSAMLTAVNSYLLTRADLED 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 176 AAKAYTWLVGSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAISLV 255
Cdd:COG4779  188 AQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVATAAA 267

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446058781 256 GNIGFVGLIAPHIAKTIVRGSYAkKLLMSAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFFIYLLL 327
Cdd:COG4779  268 GPIAFVALAAPQIARRLTRSPGP-PLLPSALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWLLI 338
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 20-327 4.18e-72

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 225.87  E-value: 4.18e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781   20 LAIVSVVSMMIGSSFIPLQRVLMYFINPNDSMDQFTLEVLRLPRITLAILAGAALGMSGLMLQNVLKNPIASPDIIGITG 99
Cdd:pfam01032   2 LLLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  100 GASLSAVVFIAFFSHLTIHLLPLFAVLGGAVAMMILLVF-QTKGQIRPTTLIIIGISMQTLFIALVQGLLITTKQLSAAK 178
Cdd:pfam01032  82 GAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLsRGRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  179 AYTWLVGSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAISLVGNI 258
Cdd:pfam01032 162 ILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPI 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446058781  259 GFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFFIYLLL 327
Cdd:pfam01032 242 GFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLL 310
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
16-327 2.43e-62

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 209.70  E-value: 2.43e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  16 ALIFLAIVSVVSMMIGSSFIPLQRVLmyfinpnDSMDQFTLEvLRLPRITLAILAGAALGMSGLMLQNVLKNPIASPDII 95
Cdd:PRK10577 361 LGLLLLLALVVALSFGRDAHGWNWLS-------GQLLDALLP-LRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVL 432

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  96 GITGGASLSAVVFIAFFSHLTIHLLPLFAVLGGAVAMMILLVFQTKGQIRPTTLIIIGISMQTLFIALVQgLLITTKQLS 175
Cdd:PRK10577 433 GISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLARRGGFAPERLLLTGIALSALFTALIQ-LLLASGDPR 511

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 176 AAKAYTWLVGSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAISLV 255
Cdd:PRK10577 512 AAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATV 591

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446058781 256 GNIGFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFFIYLLL 327
Cdd:PRK10577 592 GPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLR 663
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
13-330 6.55e-52

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 174.08  E-value: 6.55e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  13 LIFALIFLAIVSVVSMMIGSSFIPLQRVLMYFiNPNDSmDQFTLEVLRLPRITLAILAGAALGMSGLMLQNVLKNPIASP 92
Cdd:PRK09777   6 VIFITLALAGCALLSLRMGVIPLPWRALLTDW-QAGDE-HYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  93 DIIGITGGASLSAVVFIAFFSHLTIHLLPLFAVLGGAVAMMILLVFQtkGQIRPTTLIIIGISMQTLFIALVQgLLITTK 172
Cdd:PRK09777  84 DILGVNHAASLASVGALLLFPSLPVMWLPLLAFIGGMAGLILLKMLA--GTHQPMKLALTGVALSALWASLTD-YLMLSR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 173 QLSAAKAYTWLVGSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAI 252
Cdd:PRK09777 161 PQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGV 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446058781 253 SLVGNIGFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFFIYLLLTVK 330
Cdd:PRK09777 241 AACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
13-327 3.20e-45

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 163.47  E-value: 3.20e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  13 LIFALIFLAIVSVVSMMIGSSFIPLQRVLMYFINPNDSMDQFTLEVLRLPRITLAILAGAALGMSGLMLQNVLKNPIASP 92
Cdd:PRK10577  15 LLLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  93 DIIGITGGASLSAVVFIAFFSHLTIHLLPLFAVLGGAVAMMILLVFQTKGQIRPTTLIIIGISMQTLFIALVQGLLITTK 172
Cdd:PRK10577  95 TTLGVAAGAQLALVLATLFAPALLALASQLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGALTTLLLLFNE 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 173 QlSAAKAYTWLVGSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAI 252
Cdd:PRK10577 175 Q-YLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVV 253

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446058781 253 SLVGNIGFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTL--FLPKEVPAGVFIAAFGAPFFIYLLL 327
Cdd:PRK10577 254 SAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLagVGGELLPTGAVTALIGAPLLLWLLP 330
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 66-326 1.33e-40

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 142.70  E-value: 1.33e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  66 LAILAGAALGMSGLMLQNVLKNPIASPDIIGITGGASLSAVVFIAFFSHLTIHLLPLFAVLGGAVAMMILLVFQTKGQIR 145
Cdd:cd06550    3 AALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGGLS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 146 PTTLIIIGISMQTLFIALVQgLLITTKQLSAAKAYTWLVGSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPV 225
Cdd:cd06550   83 PSKLILIGIVLSAFFSAGVI-LISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 226 AIGLGLHVQRMKLIQLITSTILVSMAISLVGNIGFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFlP 305
Cdd:cd06550  162 AKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL-P 240

                        250       260
                 ....*....|....*....|.
gi 446058781 306 KEVPAGVFIAAFGAPFFIYLL 326
Cdd:cd06550  241 SELPVGPVTALLGAPYFLYLL 261
btuC PRK09535
cobalamin ABC transporter permease BtuC;
53-328 4.00e-40

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 144.51  E-value: 4.00e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  53 QFTLEVLRLPRITLAILAGAALGMSGLMLQNVLKNPIASPDIIGITGGASLSAVVFIAFFSHLTIHlLPLFAVLGGAVAM 132
Cdd:PRK09535  88 QTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLAVPFG-LQAAAFAGALVAA 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 133 MILLVFQTKGQIRPT-TLIIIGISMQTLFIALVQGLLITTKQlSAAKAYTWLVGSLYGATFKDTIILGMVILAVVPLLFL 211
Cdd:PRK09535 167 FGVYAIATENGRTPVaTLLLAGVAVQTFLGAVISYLLLHSGE-SLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLA 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 212 VIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAISLVGNIGFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAIS 291
Cdd:PRK09535 246 YARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASF 325

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 446058781 292 IVIADLIGRTlfLPKEVPAGVFIAAFGAPFFIYLLLT 328
Cdd:PRK09535 326 LVATDTVARS--GPAEVPVGIVTAALGAPFFLYLLRT 360
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
49-325 2.66e-39

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 140.99  E-value: 2.66e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  49 DSMDQFTLEVLRLPRITLAILAGAALGMSGLMLQNVLKNPIASPDIIGITGGASLSAVVFIAFF-SHLTIHLLPLFAVLG 127
Cdd:PRK11228  40 PTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSpTPFAGYSLAFIAACG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 128 GAVAMmiLLVFQTKGQIRPTT----LIIIGISMQTLFIALVQGLLITTKQlSAAKAYTWLVGSLYGATFKDTIILGMVIL 203
Cdd:PRK11228 120 GGLSW--LLVMTAGGGWRHTHdrnrLILAGIALSALCMALTRITLLLAED-HAYGIFYWLAGGVSHARWQEVWQLLPFVV 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 204 AVVPLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAISLVGNIGFVGLIAPHIAKTIVRGSYAKKLLM 283
Cdd:PRK11228 197 TAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPM 276

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 446058781 284 SAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFFIYL 325
Cdd:PRK11228 277 SMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWL 318
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 7-330 1.30e-38

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 139.32  E-value: 1.30e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781   7 KKDNYHLIFALIFLAIVSVVSMMIGSSFIPLQRVLMyfinpnDSMDQFTLEvLRLPRITLAILAGAALGMSGLMLQNVLK 86
Cdd:PRK03784  12 RRNRRWLLGLSVLLLLALLLSLCAGEQWISPGDWLS------PRGELFVWQ-LRLPRTLAVLLVGAALAVSGAVMQALFE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  87 NPIASPDIIGITGGASLSAVVFIAFF-SHLTIHLLPLFAVLGGAVAMMILLVFQTKGQIRPTTLIIIGISMQTLFIALVQ 165
Cdd:PRK03784  85 NPLAEPGLLGVSNGAGVALVAAVLLGqGLLPPWALSLCAIAGALLITLILLRFARRHRLSTSRLLLAGVALGIICSALMT 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 166 GLLITTKQLSAAKAYTWLVGSLYGATFKdtiiLGMVILAVVPLLFLVI---PKMKISILDDPVAIGLGLHVQRMKLIQLI 242
Cdd:PRK03784 165 WAVYFSTSLDLRQLMYWMMGGFGGVDWR----QSWLMLALLPVLIWLCcqgRPLNMLALGEISARQLGLPLWFWRNLLVL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 243 TSTILVSMAISLVGNIGFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFF 322
Cdd:PRK03784 241 ATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVF 320


                 ....*...
gi 446058781 323 IYLLLTVK 330
Cdd:PRK03784 321 IWLLLRSH 328
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 8-332 3.21e-38

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 138.45  E-value: 3.21e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781   8 KDNYHLIFALIFLAIVSVVSMMIGSSFIPLQRVLmyfinpNDSMDQFTLEvLRLPRITLAILAGAALGMSGLMLQNVLKN 87
Cdd:COG4139   10 RDRRWLLLLLLLLLLLFVLSLCAGEVWIPPTQWL------SEAWQLFVWQ-LRLPRTLAAVLVGASLAVSGAVMQALFEN 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  88 PIASPDIIGITGGASLsAVVFIAFFSH--LTIHLLPLFAVLGGAVAMMILLVFQTKGqIRPTTLIIIGISMQTLFIALVQ 165
Cdd:COG4139   83 PLAEPGLLGISNGAGV-GLVLVVLLGGglLPPWLLSLAAIAGALLVTLLLLAFARRR-LSNARLLLIGVALGIICSAIMT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 166 GLLITTKQLSAAKAYTWLVGSLYGATFKDTIILGMVILAVVpLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITST 245
Cdd:COG4139  161 WAVYFSSSLDLRQLMYWMMGSFGGVDWRQLWLLLALLPVLL-WLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 246 ILVSMAISLVGNIGFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFFIYL 325
Cdd:COG4139  240 LLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATLGAPVFIWL 319


                 ....*..
gi 446058781 326 LLTVKKL 332
Cdd:COG4139  320 LLRRRKI 326
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
60-327 2.92e-37

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 135.99  E-value: 2.92e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  60 RLPRITLAILAGAALGMSGLMLQNVLKNPIASPDIIGITGGASLSAVVFIAFFS-HLTihLLPLFAVLGGAVAMMILLVF 138
Cdd:PRK10440  59 RLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGqDLT--AIALAAMAGGIVTSLLVWLL 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 139 QTKGQIRPTTLIIIGISMQTLFIALVQGLLITTKQLSAAKAYTWLVGSLYGATFKDTIILGMVILAVVPLLFLVIPKMKI 218
Cdd:PRK10440 137 AWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRL 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 219 SILDDPVAIGLGLHVQRMKLIQLITSTILVSMAISLVGNIGFVGLIAPHIAKTIvRGSYAKKLLMSAMIGAISIVIADLI 298
Cdd:PRK10440 217 LEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFIALVAPHIARRL-SGTARWGLTQAALCGALLLLAADLC 295

                        250       260
                 ....*....|....*....|....*....
gi 446058781 299 GRTLFLPKEVPAGVFIAAFGAPFFIYLLL 327
Cdd:PRK10440 296 AQQLFMPYQLPVGVVTVSLGGIYLIVLLI 324
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
17-325 3.81e-30

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 117.12  E-value: 3.81e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  17 LIFLAIVSVVSMMIGSSFIPLQRVLMYFINPNDSMDQFTLEVLRLPRITLAILAGAALGMSGLMLQNVLKNPIASPDIIG 96
Cdd:PRK10441  17 LLLLIIATALSLLIGAKSLPASVVLEALSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781  97 ITGGASLSAVVFIAFFSHLTIHLLPLFAVLGGAVAMMI--LLVFQTKGQIRPTTLIIIGISMQTLFIALVQGLLITTKQL 174
Cdd:PRK10441  97 VNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIvaFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446058781 175 SAAKAYtWLVGSLYGATFKDT-IILGMVILAVVPLLFLVIPKMKISILDDpVAIGLGLHVQRMKLIQLITSTILVSMAIS 253
Cdd:PRK10441 177 YDQLRF-WQAGSLDIRNLHTLkVVLIPVLIAGATALLLSRALNSLSLGSD-TATALGSRVARTQLIGLLAITVLCGSATA 254

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446058781 254 LVGNIGFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRtLFLPKEVPAGVFIAAFGAPFFIYL 325
Cdd:PRK10441 255 VVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGR-LLVPGELRVSVVSAFIGAPVLIFL 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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