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Conserved domains on  [gi|446081272|ref|WP_000159127|]
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MULTISPECIES: metalloregulator ArsR/SmtB family transcription factor [Staphylococcaceae]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 16677510)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 31-107 2.45e-30

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


:

Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 103.31  E-value: 2.45e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446081272  31 VAKVFKALSDDTRVKIAYVLSlEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSLDDEHVKQLV 107
Cdd:NF033788   1 LAELFKALADPTRLRILELLA-EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 31-107 2.45e-30

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 103.31  E-value: 2.45e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446081272  31 VAKVFKALSDDTRVKIAYVLSlEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSLDDEHVKQLV 107
Cdd:NF033788   1 LAELFKALADPTRLRILELLA-EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
30-108 1.02e-27

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 97.27  E-value: 1.02e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446081272  30 DVAKVFKALSDDTRVKIAYVLSlEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSLDDEHVKQLVE 108
Cdd:COG0640    9 ELAELFKALADPTRLRILRLLA-EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 35-110 5.44e-19

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 74.64  E-value: 5.44e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446081272  35 FKALSDDTRVKIAYVLsLEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSLDD-EHVKQLVEKA 110
Cdd:cd00090    1 LKALSDPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaERLLALLESL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
45-110 1.08e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 73.78  E-value: 1.08e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446081272    45 KIAYVLSlEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSLDDEHVKQLVEKA 110
Cdd:smart00418   1 KILKLLA-EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 33-116 1.58e-16

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 69.46  E-value: 1.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446081272  33 KVFKALSDDTRVKIAYVLSLEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSLdDEHV----KQLVE 108
Cdd:PRK10141   8 QLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL-SPHIpawaAKIIE 86


                 ....*...
gi 446081272 109 KAFLHQRE 116
Cdd:PRK10141  87 QAWLCEQE 94
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 34-98 2.39e-12

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 57.81  E-value: 2.39e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446081272  34 VFKALSDDTRVKIayvLSL--EGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSL 98
Cdd:NF033789   1 TFKALSDPTRREI---LELlkEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 40-84 9.40e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 52.83  E-value: 9.40e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 446081272   40 DDTRVKIAYVLSlEGELCVCDVANIIESSTATASHHLRLLKNLGI 84
Cdd:pfam01022   1 DPTRLKILKLLA-EGELCVCELAEELGLSQSTVSHHLKKLREAGL 44
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 31-107 2.45e-30

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 103.31  E-value: 2.45e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446081272  31 VAKVFKALSDDTRVKIAYVLSlEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSLDDEHVKQLV 107
Cdd:NF033788   1 LAELFKALADPTRLRILELLA-EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
30-108 1.02e-27

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 97.27  E-value: 1.02e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446081272  30 DVAKVFKALSDDTRVKIAYVLSlEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSLDDEHVKQLVE 108
Cdd:COG0640    9 ELAELFKALADPTRLRILRLLA-EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 35-110 5.44e-19

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 74.64  E-value: 5.44e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446081272  35 FKALSDDTRVKIAYVLsLEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSLDD-EHVKQLVEKA 110
Cdd:cd00090    1 LKALSDPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaERLLALLESL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
45-110 1.08e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 73.78  E-value: 1.08e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446081272    45 KIAYVLSlEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSLDDEHVKQLVEKA 110
Cdd:smart00418   1 KILKLLA-EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 33-116 1.58e-16

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 69.46  E-value: 1.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446081272  33 KVFKALSDDTRVKIAYVLSLEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSLdDEHV----KQLVE 108
Cdd:PRK10141   8 QLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL-SPHIpawaAKIIE 86


                 ....*...
gi 446081272 109 KAFLHQRE 116
Cdd:PRK10141  87 QAWLCEQE 94
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 34-98 2.39e-12

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 57.81  E-value: 2.39e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446081272  34 VFKALSDDTRVKIayvLSL--EGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSL 98
Cdd:NF033789   1 TFKALSDPTRREI---LELlkEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 40-84 9.40e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 52.83  E-value: 9.40e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 446081272   40 DDTRVKIAYVLSlEGELCVCDVANIIESSTATASHHLRLLKNLGI 84
Cdd:pfam01022   1 DPTRLKILKLLA-EGELCVCELAEELGLSQSTVSHHLKKLREAGL 44
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 32-92 1.99e-07

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 44.45  E-value: 1.99e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446081272   32 AKVFKALSDDTRVKIAYVLSLEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGK 92
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
27-84 9.32e-07

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 43.80  E-value: 9.32e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446081272  27 NPMDVAKVFKALSDDTRVKIAYVLSlEGELCVCDVANIIESSTATASHHLRLLKNLGI 84
Cdd:COG4189    5 DDEESLEVLKALASETRLRILRLLA-EEPLNVNELAEALGLPKSTVSYHIRKLEEAGL 61
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
33-101 2.73e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 41.02  E-value: 2.73e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446081272  33 KVFKALSDDTRVKIAYVLSLEGELCVCDVANIIESSTATASHHLRLLKNLGIAKYRKEGKLVYYSLDDE 101
Cdd:COG3398   89 KILAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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