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Conserved domains on  [gi|446104399|ref|WP_000182254|]
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MULTISPECIES: type III toxin-antitoxin system ToxN/AbiQ family toxin [Bacillus cereus group]

Protein Classification

type III toxin-antitoxin system ToxN/AbiQ family toxin( domain architecture ID 10622606)

type III toxin-antitoxin (TA) system ToxN/AbiQ family toxin similar to Pectobacterium carotovorum ToxN and Lactococcus lactis AbiQ, toxin components of the plasmid-encoded ToxN-ToxI and AbiQ-antiQ TA modules respectively; ToxN and AbiQ are endoribonucleases that specifically cleave their cognate antitoxin RNA molecules in vivo

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ToxN_toxin pfam13958
Toxin ToxN, type III toxin-antitoxin system; ToxN acts as a toxin, it is part of a type III ...
 8-166 2.21e-44

Toxin ToxN, type III toxin-antitoxin system; ToxN acts as a toxin, it is part of a type III toxin-antitoxin system. It acts as a ribosome independent endoribonuclease. It interacts with, and is inhibited by, the RNA antitoxin, ToxI. Three ToxN monomers bind to three ToxI monomers to create a trimeric ToxN-ToxI complex.


:

Pssm-ID: 433605  Cd Length: 155  Bit Score: 144.69  E-value: 2.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446104399    8 KFHTISTEYIDYLREADSKVPFNKDEQHSRPYVGVLEKINGHDYFVPLTS---RNDKNFNSQVSVKLFDNDEKRIGVLLV 84
Cdd:pfam13958   1 KLYNVDDDYIKYLRKFDSRVPYNKYNKKNRPFVGILLTINDIKYFVPLSSpkpKHKKMKNNPDFIKIYNDKKKLLGVLNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446104399   85 NNMIPVPEKECKEIDIAEktAADPQYGNLMLKQYLFLKENMDRVTNKVEKVYKDVTvqgkpSHKQKFLKGVCCDFPKLEE 164
Cdd:pfam13958  81 NNMIPVPDDVLSLLDINN--IEDSKYKDLLQKEYKFINKNKEEILKKAKKLYKKKI-----NKKNSFLKKRCCDFKLLEE 153


                  ..
gi 446104399  165 KC 166
Cdd:pfam13958 154 KC 155
 
Name Accession Description Interval E-value
ToxN_toxin pfam13958
Toxin ToxN, type III toxin-antitoxin system; ToxN acts as a toxin, it is part of a type III ...
 8-166 2.21e-44

Toxin ToxN, type III toxin-antitoxin system; ToxN acts as a toxin, it is part of a type III toxin-antitoxin system. It acts as a ribosome independent endoribonuclease. It interacts with, and is inhibited by, the RNA antitoxin, ToxI. Three ToxN monomers bind to three ToxI monomers to create a trimeric ToxN-ToxI complex.


Pssm-ID: 433605  Cd Length: 155  Bit Score: 144.69  E-value: 2.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446104399    8 KFHTISTEYIDYLREADSKVPFNKDEQHSRPYVGVLEKINGHDYFVPLTS---RNDKNFNSQVSVKLFDNDEKRIGVLLV 84
Cdd:pfam13958   1 KLYNVDDDYIKYLRKFDSRVPYNKYNKKNRPFVGILLTINDIKYFVPLSSpkpKHKKMKNNPDFIKIYNDKKKLLGVLNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446104399   85 NNMIPVPEKECKEIDIAEktAADPQYGNLMLKQYLFLKENMDRVTNKVEKVYKDVTvqgkpSHKQKFLKGVCCDFPKLEE 164
Cdd:pfam13958  81 NNMIPVPDDVLSLLDINN--IEDSKYKDLLQKEYKFINKNKEEILKKAKKLYKKKI-----NKKNSFLKKRCCDFKLLEE 153


                  ..
gi 446104399  165 KC 166
Cdd:pfam13958 154 KC 155
 
Name Accession Description Interval E-value
ToxN_toxin pfam13958
Toxin ToxN, type III toxin-antitoxin system; ToxN acts as a toxin, it is part of a type III ...
 8-166 2.21e-44

Toxin ToxN, type III toxin-antitoxin system; ToxN acts as a toxin, it is part of a type III toxin-antitoxin system. It acts as a ribosome independent endoribonuclease. It interacts with, and is inhibited by, the RNA antitoxin, ToxI. Three ToxN monomers bind to three ToxI monomers to create a trimeric ToxN-ToxI complex.


Pssm-ID: 433605  Cd Length: 155  Bit Score: 144.69  E-value: 2.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446104399    8 KFHTISTEYIDYLREADSKVPFNKDEQHSRPYVGVLEKINGHDYFVPLTS---RNDKNFNSQVSVKLFDNDEKRIGVLLV 84
Cdd:pfam13958   1 KLYNVDDDYIKYLRKFDSRVPYNKYNKKNRPFVGILLTINDIKYFVPLSSpkpKHKKMKNNPDFIKIYNDKKKLLGVLNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446104399   85 NNMIPVPEKECKEIDIAEktAADPQYGNLMLKQYLFLKENMDRVTNKVEKVYKDVTvqgkpSHKQKFLKGVCCDFPKLEE 164
Cdd:pfam13958  81 NNMIPVPDDVLSLLDINN--IEDSKYKDLLQKEYKFINKNKEEILKKAKKLYKKKI-----NKKNSFLKKRCCDFKLLEE 153


                  ..
gi 446104399  165 KC 166
Cdd:pfam13958 154 KC 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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