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Conserved domains on  [gi|446109308|ref|WP_000187163|]
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MULTISPECIES: AraC family transcriptional regulator [Acinetobacter]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 11677366)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  33837749|12596232|10473770|15808743|9409145|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
249-336 2.01e-24

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 100.24  E-value: 2.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308 249 EILKVKQVAQMMNMSERSLQRYLAIE-NTSFSALVDLTRKQYAQDLLQNSSMSIEAVALSLGYADTPHFTRAFKRWMGVT 327
Cdd:COG2207  167 LLLTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVT 246


                 ....*....
gi 446109308 328 PKYYQTQLK 336
Cdd:COG2207  247 PSEYRKRLR 255
Arabinose_bd super family cl14988
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 21-203 5.78e-15

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


The actual alignment was detected with superfamily member pfam12625:

Pssm-ID: 432679  Cd Length: 185  Bit Score: 72.29  E-value: 5.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308   21 GISCEQFLEGSGVTPEQLKKPYWYVEFNILNNLLEHAIQLTHEPALAGYLALEMKASCYGSVGMAAMVSANLEEALKILE 100
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308  101 QFIGSRCDAFKPELKQEQDDVYW-SIHQPLKSFQLSSDATIFLLLGFVYIAKHLTGVS-SLGTVQLNMPEPLGFSKIKDK 178
Cdd:pfam12625  81 RYLRLLSDALELRLEEGEGGLARlRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRlPPLRVEFPHPAPADAAEYERL 160

                         170       180
                  ....*....|....*....|....*
gi 446109308  179 LGVSCLFEQKHNIWIIPKEYLMQPV 203
Cdd:pfam12625 161 FGCPVRFGAPRNALVFDAADLDRPL 185
 
Name Accession Description Interval E-value
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
249-336 2.01e-24

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 100.24  E-value: 2.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308 249 EILKVKQVAQMMNMSERSLQRYLAIE-NTSFSALVDLTRKQYAQDLLQNSSMSIEAVALSLGYADTPHFTRAFKRWMGVT 327
Cdd:COG2207  167 LLLTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVT 246


                 ....*....
gi 446109308 328 PKYYQTQLK 336
Cdd:COG2207  247 PSEYRKRLR 255
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
251-331 9.66e-24

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 93.00  E-value: 9.66e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308   251 LKVKQVAQMMNMSERSLQRYLAIE-NTSFSALVDLTRKQYAQDLLQNSSMSIEAVALSLGYADTPHFTRAFKRWMGVTPK 329
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ..
gi 446109308   330 YY 331
Cdd:smart00342  82 EY 83
HTH_18 pfam12833
Helix-turn-helix domain;
256-334 4.57e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 80.33  E-value: 4.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308  256 VAQMMNMSERSLQRYL-AIENTSFSALVDLTRKQYA-QDLLQNSSMSIEAVALSLGYADTPHFTRAFKRWMGVTPKYYQT 333
Cdd:pfam12833   1 LAAALGMSPRTLSRLFkRELGLSPKEYLRRLRLERArRLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 446109308  334 Q 334
Cdd:pfam12833  81 R 81
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 21-203 5.78e-15

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 72.29  E-value: 5.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308   21 GISCEQFLEGSGVTPEQLKKPYWYVEFNILNNLLEHAIQLTHEPALAGYLALEMKASCYGSVGMAAMVSANLEEALKILE 100
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308  101 QFIGSRCDAFKPELKQEQDDVYW-SIHQPLKSFQLSSDATIFLLLGFVYIAKHLTGVS-SLGTVQLNMPEPLGFSKIKDK 178
Cdd:pfam12625  81 RYLRLLSDALELRLEEGEGGLARlRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRlPPLRVEFPHPAPADAAEYERL 160

                         170       180
                  ....*....|....*....|....*
gi 446109308  179 LGVSCLFEQKHNIWIIPKEYLMQPV 203
Cdd:pfam12625 161 FGCPVRFGAPRNALVFDAADLDRPL 185
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 242-331 1.86e-09

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 58.08  E-value: 1.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308 242 LLINSQGEILKVKQVAQMMNMSERSLQRYLAIENTSFSALVDLTRKQYAQDLLQNSSMSIEAVALSLGYADTPHFTRAFK 321
Cdd:PRK15185 214 IISSSPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFK 293

                         90
                 ....*....|
gi 446109308 322 RWMGVTPKYY 331
Cdd:PRK15185 294 KYFKTTPSTF 303
adjacent_YSIRK TIGR04094
YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only ...
 251-332 1.05e-08

YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.


Pssm-ID: 274977 [Multi-domain]  Cd Length: 383  Bit Score: 56.22  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308  251 LKVKQVAQMMNMSERSLQRylaientSFSALVDLTRKQY--------AQDLLQnSSMSIEAVALSLGYADTPHFTRAFKR 322
Cdd:TIGR04094 302 LKVEEIAKQFFMSESKLRK-------LFKKEMGISIQEYiskrkieeAKYLLR-SQIPVSEVSNELGFYDLSHFSRTFKK 373

                          90
                  ....*....|
gi 446109308  323 WMGVTPKYYQ 332
Cdd:TIGR04094 374 HTGVSPKQYQ 383
 
Name Accession Description Interval E-value
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
249-336 2.01e-24

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 100.24  E-value: 2.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308 249 EILKVKQVAQMMNMSERSLQRYLAIE-NTSFSALVDLTRKQYAQDLLQNSSMSIEAVALSLGYADTPHFTRAFKRWMGVT 327
Cdd:COG2207  167 LLLTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVT 246


                 ....*....
gi 446109308 328 PKYYQTQLK 336
Cdd:COG2207  247 PSEYRKRLR 255
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
251-331 9.66e-24

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 93.00  E-value: 9.66e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308   251 LKVKQVAQMMNMSERSLQRYLAIE-NTSFSALVDLTRKQYAQDLLQNSSMSIEAVALSLGYADTPHFTRAFKRWMGVTPK 329
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ..
gi 446109308   330 YY 331
Cdd:smart00342  82 EY 83
HTH_18 pfam12833
Helix-turn-helix domain;
256-334 4.57e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 80.33  E-value: 4.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308  256 VAQMMNMSERSLQRYL-AIENTSFSALVDLTRKQYA-QDLLQNSSMSIEAVALSLGYADTPHFTRAFKRWMGVTPKYYQT 333
Cdd:pfam12833   1 LAAALGMSPRTLSRLFkRELGLSPKEYLRRLRLERArRLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 446109308  334 Q 334
Cdd:pfam12833  81 R 81
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 21-203 5.78e-15

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 72.29  E-value: 5.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308   21 GISCEQFLEGSGVTPEQLKKPYWYVEFNILNNLLEHAIQLTHEPALAGYLALEMKASCYGSVGMAAMVSANLEEALKILE 100
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308  101 QFIGSRCDAFKPELKQEQDDVYW-SIHQPLKSFQLSSDATIFLLLGFVYIAKHLTGVS-SLGTVQLNMPEPLGFSKIKDK 178
Cdd:pfam12625  81 RYLRLLSDALELRLEEGEGGLARlRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRlPPLRVEFPHPAPADAAEYERL 160

                         170       180
                  ....*....|....*....|....*
gi 446109308  179 LGVSCLFEQKHNIWIIPKEYLMQPV 203
Cdd:pfam12625 161 FGCPVRFGAPRNALVFDAADLDRPL 185
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 248-331 1.30e-14

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 73.27  E-value: 1.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308 248 GEILKVKQVAQMMNMSERSLQRylaientSFSALVDLTRKQY--------AQDLLQNSSMSIEAVALSLGYADTPHFTRA 319
Cdd:COG4977  224 EEPLSVDELARRAGMSPRTLER-------RFRAATGTTPARYlqrlrlerARRLLETTDLSIEEIAAACGFGSASHFRRA 296

                         90
                 ....*....|..
gi 446109308 320 FKRWMGVTPKYY 331
Cdd:COG4977  297 FRRRFGVSPSAY 308
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 242-331 1.86e-09

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 58.08  E-value: 1.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308 242 LLINSQGEILKVKQVAQMMNMSERSLQRYLAIENTSFSALVDLTRKQYAQDLLQNSSMSIEAVALSLGYADTPHFTRAFK 321
Cdd:PRK15185 214 IISSSPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFK 293

                         90
                 ....*....|
gi 446109308 322 RWMGVTPKYY 331
Cdd:PRK15185 294 KYFKTTPSTF 303
ftrA PRK09393
transcriptional activator FtrA; Provisional
 253-334 3.19e-09

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 57.28  E-value: 3.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308 253 VKQVAQMMNMSERSLQRylaientSFSALVDLT--------RKQYAQDLLQNSSMSIEAVALSLGYADTPHFTRAFKRWM 324
Cdd:PRK09393 237 VASLAARAAMSPRTFLR-------RFEAATGMTpaewllreRLARARDLLESSALSIDQIAERAGFGSEESLRHHFRRRA 309

                         90
                 ....*....|
gi 446109308 325 GVTPKYYQTQ 334
Cdd:PRK09393 310 ATSPAAYRKR 319
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 233-335 6.72e-09

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 56.19  E-value: 6.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308 233 AEISQVIKKLLINSQGEILKVKQVAQMMNMSERSLQRYLAIENTSFSALVDLTRKQYAQDLLQNSSM--SIEAVALSLGY 310
Cdd:PRK09685 197 RQFQKVVALIDQSIQEEILRPEWIAGELGISVRSLYRLFAEQGLVVAQYIRNRRLDRCADDLRPAADdeKITSIAYKWGF 276

                         90       100
                 ....*....|....*....|....*
gi 446109308 311 ADTPHFTRAFKRWMGVTPKYYQTQL 335
Cdd:PRK09685 277 SDSSHFSTAFKQRFGVSPGEYRRKF 301
adjacent_YSIRK TIGR04094
YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only ...
 251-332 1.05e-08

YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.


Pssm-ID: 274977 [Multi-domain]  Cd Length: 383  Bit Score: 56.22  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308  251 LKVKQVAQMMNMSERSLQRylaientSFSALVDLTRKQY--------AQDLLQnSSMSIEAVALSLGYADTPHFTRAFKR 322
Cdd:TIGR04094 302 LKVEEIAKQFFMSESKLRK-------LFKKEMGISIQEYiskrkieeAKYLLR-SQIPVSEVSNELGFYDLSHFSRTFKK 373

                          90
                  ....*....|
gi 446109308  323 WMGVTPKYYQ 332
Cdd:TIGR04094 374 HTGVSPKQYQ 383
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
290-334 1.64e-07

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 51.90  E-value: 1.64e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 446109308 290 AQDLLQNSSMSIEAVALSLGYADTPHFTRAFKRWMGVTPKYYQTQ 334
Cdd:PRK10572 240 AKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRAR 284
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 256-332 5.22e-07

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 50.31  E-value: 5.22e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446109308 256 VAQMMNMSERSLQRYLAIENTSFSALVDLTRKQYAQDLLQNSSMSIEAVALSLGYADTPHFTRAFKRWMGVTPKYYQ 332
Cdd:PRK09978 164 IASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQ 240
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 235-331 1.09e-06

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 49.68  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308 235 ISQVIKKLLINSQGEILKVKQVAQMMNMSERSLQRYLAIENTSFSALVDLTRKQYAQDLLQNSSMSIEAVALSLGYADTP 314
Cdd:PRK15186 182 LAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSAS 261

                         90
                 ....*....|....*..
gi 446109308 315 HFTRAFKRWMGVTPKYY 331
Cdd:PRK15186 262 YFTCVFKKHFKTTPSEF 278
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 252-329 2.86e-06

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 48.16  E-value: 2.86e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446109308 252 KVKQVAQMMNMSERSLQRYLAIENTSFSALVDLTRKQYAQDLLQNSSmSIEAVALSLGYADTPHFTRAFKRWMGVTPK 329
Cdd:PRK09940 152 KLKDICDCLYISESLLKKKLKQEQTTFSQILLDARMQHAKNLIRVEG-SVNKIAEQCGYASTSYFIYAFRKHFGNSPK 228
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 297-333 6.61e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 42.53  E-value: 6.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 446109308  297 SSMSIEAVALSLGYaDTPHFTRAFKRWMGVTPKYYQT 333
Cdd:pfam00165   7 TNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 255-328 1.85e-04

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 42.71  E-value: 1.85e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446109308 255 QVAQMMNMSERSLQRYLAIENTSFSALVDLTRKQYAQDLLQNSSMSIEAVALSLGYADTPHFTRAFKRWMGVTP 328
Cdd:PRK15044 213 EVAGKLFMSVSSLKRKLAAEEVSFSKIYLDARMNQAIKLLRMGAGNISQVATMCGYDTPSYFIAIFKRHFKITP 286
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
243-332 7.91e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 40.81  E-value: 7.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446109308 243 LINSQGEILKVKQVAQMMNMSERSL-QRYLAIENTSFSALVDLTRKQYAQDLLQNSSMSIEAVALSLGYADTPHFTRAFK 321
Cdd:PRK13502 185 LANSLECPFALDAFCQQEQCSERVLrQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFT 264

                         90
                 ....*....|.
gi 446109308 322 RWMGVTPKYYQ 332
Cdd:PRK13502 265 RETGMTPSQWR 275
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
264-338 2.15e-03

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 39.38  E-value: 2.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446109308 264 ERSLQRYLAIENTSFSALVDLTRKQYAQDLLQNSSMSIEAVALSLGYADTpHFTRAFKRWMGVTPKYYQTQLKLK 338
Cdd:COG2207  134 LELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPR-TLSRLFKEETGTSPKQYLRELRLE 207
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
255-329 3.79e-03

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 38.50  E-value: 3.79e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446109308 255 QVAQMMNMSERSLQRYLAiENTSFSALVDLTRKQYAQ--DLLQNSSMSIEAVALSLGYADTPHFTRAFKRWMGVTPK 329
Cdd:PRK13503 192 ALADQFSLSLRTLHRQLK-QQTGLTPQRYLNRLRLLKarHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPR 267
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 300-337 5.34e-03

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 38.50  E-value: 5.34e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446109308 300 SIEAVALSLGYADTpHFTRAFKRWMGVTPKYYQTQLKL 337
Cdd:COG2169  102 SLEDLAARLGLSPR-HLRRLFKAHTGVTPKAYARARRL 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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