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Conserved domains on  [gi|446126955|ref|WP_000204810|]
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MULTISPECIES: MFS transporter [Enterobacteriaceae]

Protein Classification

MFS transporter( domain architecture ID 13023745)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
25-449 1.78e-111

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 335.34  E-value: 1.78e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRPWQLWIAIPI 104
Cdd:cd17332    1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 105 GIIGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFLVSVGLPWMV 184
Cdd:cd17332   81 ALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 185 DLFGQGNAARGYQLGVGVLCAIAVVMFLCCFFWVRERVPLSTMGKF--TLREHLAGLRNNDQLLLMLVMSFLLINVFNIR 262
Cdd:cd17332  161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSklPLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 263 GGGYMYFITYVLqGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPAYqtLWLAV 342
Cdd:cd17332  241 NTVLVYYFKYVL-GGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLV--LILVL 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 343 ILGNGVILGFTLPLHFSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVENQTASSLGG 422
Cdd:cd17332  318 AVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNG 397
                        410       420
                 ....*....|....*....|....*..
gi 446126955 423 IAAMETLLPALFHLLLAGAIRFCKLNN 449
Cdd:cd17332  398 IRLLIAVLPAVLLLLALILMSFYPLDK 424
 
Name Accession Description Interval E-value
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
25-449 1.78e-111

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 335.34  E-value: 1.78e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRPWQLWIAIPI 104
Cdd:cd17332    1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 105 GIIGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFLVSVGLPWMV 184
Cdd:cd17332   81 ALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 185 DLFGQGNAARGYQLGVGVLCAIAVVMFLCCFFWVRERVPLSTMGKF--TLREHLAGLRNNDQLLLMLVMSFLLINVFNIR 262
Cdd:cd17332  161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSklPLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 263 GGGYMYFITYVLqGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPAYqtLWLAV 342
Cdd:cd17332  241 NTVLVYYFKYVL-GGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLV--LILVL 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 343 ILGNGVILGFTLPLHFSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVENQTASSLGG 422
Cdd:cd17332  318 AVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNG 397
                        410       420
                 ....*....|....*....|....*..
gi 446126955 423 IAAMETLLPALFHLLLAGAIRFCKLNN 449
Cdd:cd17332  398 IRLLIAVLPAVLLLLALILMSFYPLDK 424
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
18-463 1.75e-101

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 310.68  E-value: 1.75e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  18 DALSVREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRPWQ 97
Cdd:COG2211    5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  98 LWIAIPIGIIGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFLVS 177
Cdd:COG2211   85 LIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLAS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 178 VGLPWMVDLFGqGNAARGYQLGVGVLCAIAVVMFLCCFFWVRERVPLSTmGKFTLREHLAGLRNNDQLLLMLVMSFLLIN 257
Cdd:COG2211  165 VLPPPLVAAFG-GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-EKVSLKESLKALLKNRPFLLLLLAYLLFFL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 258 VFNIRGGGYMYFITYVLQGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPAYqt 337
Cdd:COG2211  243 ALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLW-- 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 338 LWLAVILGNGVILGFTLPLHFSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVEnQTA 417
Cdd:COG2211  321 LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAA-QSP 399
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 446126955 418 SSLGGIAAMETLLPALFHLLLAGAIRFCKLNNPMMSRIATDLRQRH 463
Cdd:COG2211  400 SALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARR 445
PRK09669 PRK09669
putative symporter YagG; Provisional
16-461 5.46e-91

putative symporter YagG; Provisional


Pssm-ID: 236610  Cd Length: 444  Bit Score: 283.54  E-value: 5.46e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  16 IDDALSVREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRP 95
Cdd:PRK09669   2 NTSQLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  96 WQLWIAIPIGIIGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFL 175
Cdd:PRK09669  82 YLLWFAIPFGVVCLLTFYTPDFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 176 VSV-GLPwMVDLFGQGNAARGYQLGVGVLCAIAVVMFLCCFFWVRERVPLSTMGKFTLREHLAGLRNNDQLLLMLVMSFL 254
Cdd:PRK09669 162 VSViALP-LVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSSSVWKDLKLLLGNSQWRIMFIFNVV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 255 LINVFNIRGGGYMYFITYVLqGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPA 334
Cdd:PRK09669 241 LLTAVVTRGGATLYYVNYVL-LRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPPSNV 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 335 YQTLWLAVILgnGVILGFTLPLHFSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVEN 414
Cdd:PRK09669 320 WLIFALNILF--NFIQNLTTPLQWSMFSDVVDYEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAVVGWILAWVDYVGGAAV 397
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 446126955 415 QTASSLGGIAAMETLLPALFHLLLAGAIRFCKLNNPMMSRIATDLRQ 461
Cdd:PRK09669 398 QSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDARVEAIAQELVK 444
gph TIGR00792
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ...
25-462 7.79e-87

sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273270  Cd Length: 437  Bit Score: 272.59  E-value: 7.79e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955   25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRPWQLWIAIPI 104
Cdd:TIGR00792   1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  105 GIIGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFLVSVGLPWMV 184
Cdd:TIGR00792  81 SIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  185 DLFGQGNAARGYQLGVGVLCAIAVVMFLCCFFWVRERV---PLSTMGKFTLREHLAGLRNNDQLLLMLVMSFLLINVFNI 261
Cdd:TIGR00792 161 SYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYseiPKNIEKKLSLKQIFKALFKNDQLLILCLAYLFYNLAFNI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  262 RGGGYMYFITYVLqGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPAYQTLWLA 341
Cdd:TIGR00792 241 KNGVQVYYFTYVL-GDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLPLILVLII 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  342 VIlgnGVILGFTLPLHFSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVEnQTASSLG 421
Cdd:TIGR00792 320 LA---GFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANAA-QSPITLN 395
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 446126955  422 GIAAMETLLPALFHLLLAGAI-RFCKLNNPMMSRIATDLRQR 462
Cdd:TIGR00792 396 GIKILMFAVPALFLLLAAIIIgRFYKLTEKKHAEIVEELEQR 437
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
27-424 7.71e-54

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 185.98  E-value: 7.71e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955   27 GYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRPWQLWIAIPIGI 106
Cdd:pfam13347   1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  107 IGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFLVSVGLPWMVDL 186
Cdd:pfam13347  81 SFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVLI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  187 FGQ-GNAARGYQLGVGVLCAIAVVMFLCCFFWVRERVPLSTMGKFTLREHLAGLR------NNDQLLLMLVMSFLLINVF 259
Cdd:pfam13347 161 LGGtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDmlkevfRNRAFLILLASFLLAALAM 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  260 NIRGGGYMYFITYVLqGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPAYQTLW 339
Cdd:pfam13347 241 GVLNGLLLYYFRYVL-GNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLV 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  340 LAVILGNGVILGFTLPLhfSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVENQTASS 419
Cdd:pfam13347 320 LYIIIGFGYGSSFFLPW--SMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQA 397

                  ....*
gi 446126955  420 LGGIA 424
Cdd:pfam13347 398 VTAIR 402
 
Name Accession Description Interval E-value
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
25-449 1.78e-111

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 335.34  E-value: 1.78e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRPWQLWIAIPI 104
Cdd:cd17332    1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 105 GIIGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFLVSVGLPWMV 184
Cdd:cd17332   81 ALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 185 DLFGQGNAARGYQLGVGVLCAIAVVMFLCCFFWVRERVPLSTMGKF--TLREHLAGLRNNDQLLLMLVMSFLLINVFNIR 262
Cdd:cd17332  161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSklPLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 263 GGGYMYFITYVLqGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPAYqtLWLAV 342
Cdd:cd17332  241 NTVLVYYFKYVL-GGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLV--LILVL 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 343 ILGNGVILGFTLPLHFSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVENQTASSLGG 422
Cdd:cd17332  318 AVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNG 397
                        410       420
                 ....*....|....*....|....*..
gi 446126955 423 IAAMETLLPALFHLLLAGAIRFCKLNN 449
Cdd:cd17332  398 IRLLIAVLPAVLLLLALILMSFYPLDK 424
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
18-463 1.75e-101

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 310.68  E-value: 1.75e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  18 DALSVREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRPWQ 97
Cdd:COG2211    5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  98 LWIAIPIGIIGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFLVS 177
Cdd:COG2211   85 LIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLAS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 178 VGLPWMVDLFGqGNAARGYQLGVGVLCAIAVVMFLCCFFWVRERVPLSTmGKFTLREHLAGLRNNDQLLLMLVMSFLLIN 257
Cdd:COG2211  165 VLPPPLVAAFG-GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-EKVSLKESLKALLKNRPFLLLLLAYLLFFL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 258 VFNIRGGGYMYFITYVLQGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPAYqt 337
Cdd:COG2211  243 ALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLW-- 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 338 LWLAVILGNGVILGFTLPLHFSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVEnQTA 417
Cdd:COG2211  321 LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAA-QSP 399
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 446126955 418 SSLGGIAAMETLLPALFHLLLAGAIRFCKLNNPMMSRIATDLRQRH 463
Cdd:COG2211  400 SALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARR 445
PRK09669 PRK09669
putative symporter YagG; Provisional
16-461 5.46e-91

putative symporter YagG; Provisional


Pssm-ID: 236610  Cd Length: 444  Bit Score: 283.54  E-value: 5.46e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  16 IDDALSVREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRP 95
Cdd:PRK09669   2 NTSQLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  96 WQLWIAIPIGIIGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFL 175
Cdd:PRK09669  82 YLLWFAIPFGVVCLLTFYTPDFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 176 VSV-GLPwMVDLFGQGNAARGYQLGVGVLCAIAVVMFLCCFFWVRERVPLSTMGKFTLREHLAGLRNNDQLLLMLVMSFL 254
Cdd:PRK09669 162 VSViALP-LVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSSSVWKDLKLLLGNSQWRIMFIFNVV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 255 LINVFNIRGGGYMYFITYVLqGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPA 334
Cdd:PRK09669 241 LLTAVVTRGGATLYYVNYVL-LRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPPSNV 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 335 YQTLWLAVILgnGVILGFTLPLHFSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVEN 414
Cdd:PRK09669 320 WLIFALNILF--NFIQNLTTPLQWSMFSDVVDYEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAVVGWILAWVDYVGGAAV 397
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 446126955 415 QTASSLGGIAAMETLLPALFHLLLAGAIRFCKLNNPMMSRIATDLRQ 461
Cdd:PRK09669 398 QSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDARVEAIAQELVK 444
gph TIGR00792
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ...
25-462 7.79e-87

sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273270  Cd Length: 437  Bit Score: 272.59  E-value: 7.79e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955   25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRPWQLWIAIPI 104
Cdd:TIGR00792   1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  105 GIIGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFLVSVGLPWMV 184
Cdd:TIGR00792  81 SIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  185 DLFGQGNAARGYQLGVGVLCAIAVVMFLCCFFWVRERV---PLSTMGKFTLREHLAGLRNNDQLLLMLVMSFLLINVFNI 261
Cdd:TIGR00792 161 SYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYseiPKNIEKKLSLKQIFKALFKNDQLLILCLAYLFYNLAFNI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  262 RGGGYMYFITYVLqGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPAYQTLWLA 341
Cdd:TIGR00792 241 KNGVQVYYFTYVL-GDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLPLILVLII 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  342 VIlgnGVILGFTLPLHFSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVEnQTASSLG 421
Cdd:TIGR00792 320 LA---GFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANAA-QSPITLN 395
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 446126955  422 GIAAMETLLPALFHLLLAGAI-RFCKLNNPMMSRIATDLRQR 462
Cdd:TIGR00792 396 GIKILMFAVPALFLLLAAIIIgRFYKLTEKKHAEIVEELEQR 437
PRK11462 PRK11462
putative transporter; Provisional
17-461 2.52e-86

putative transporter; Provisional


Pssm-ID: 183145  Cd Length: 460  Bit Score: 272.20  E-value: 2.52e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  17 DDALSVREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRPW 96
Cdd:PRK11462   3 SEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPW 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  97 QLWIAIPIGIIGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFLV 176
Cdd:PRK11462  83 VLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 177 SVGLPWMVDLFGQGNAARGYQLGVGVLCAIAVVMFLCCFFWVRERV--PLSTMgkfTLREHLAGLRNNDQLLLMLVMSFL 254
Cdd:PRK11462 163 TVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVeaPPTTT---SMREDLRDIWQNDQWRIVGLLTIF 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 255 LINVFNIRGGGYMYFITYVLqGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPA 334
Cdd:PRK11462 240 NILAVCVRGGAMMYYVTWIL-GTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQAS 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 335 YQTLWLAVILgnGVILGFTLPLHFSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVEN 414
Cdd:PRK11462 319 ITMFVFIFVI--GVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKA 396
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 446126955 415 QTASSLGGIAAMETLLPALFHLLLAG-AIRFCKLNNPMMSRIATDLRQ 461
Cdd:PRK11462 397 QNSATISIIIALFTIVPAICYLLSAIiAKRYYSLTTHNLKTVMEQLAQ 444
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
27-424 7.71e-54

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 185.98  E-value: 7.71e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955   27 GYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRPWQLWIAIPIGI 106
Cdd:pfam13347   1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  107 IGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFLVSVGLPWMVDL 186
Cdd:pfam13347  81 SFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVLI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  187 FGQ-GNAARGYQLGVGVLCAIAVVMFLCCFFWVRERVPLSTMGKFTLREHLAGLR------NNDQLLLMLVMSFLLINVF 259
Cdd:pfam13347 161 LGGtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDmlkevfRNRAFLILLASFLLAALAM 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  260 NIRGGGYMYFITYVLqGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPAYQTLW 339
Cdd:pfam13347 241 GVLNGLLLYYFRYVL-GNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLV 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  340 LAVILGNGVILGFTLPLhfSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVENQTASS 419
Cdd:pfam13347 320 LYIIIGFGYGSSFFLPW--SMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQA 397

                  ....*
gi 446126955  420 LGGIA 424
Cdd:pfam13347 398 VTAIR 402
PRK10429 PRK10429
melibiose:sodium transporter MelB;
20-426 1.36e-47

melibiose:sodium transporter MelB;


Pssm-ID: 182453  Cd Length: 473  Bit Score: 170.66  E-value: 1.36e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  20 LSVREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRPWQLW 99
Cdd:PRK10429   3 ISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTRSRWGKFKPWILI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 100 IAIPIGIIGILTFTVPDASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFLV-SV 178
Cdd:PRK10429  83 GTLANSVVLFLLFSAHLFEGTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASLAGFVTaGF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 179 GLPwMVDLFGQGNAARGYQLGVGVLCAIAVVMFLCCFFWVRER-----VPLSTMGKFTLREHLAGLRNNDQLLLMLVMSF 253
Cdd:PRK10429 163 TLP-FVNYVGGGDRGFGFQMFTLVLIAFFIVSTIITLRNVHEVyssdnQVSAEGSHLTLKDIVALIYKNDQLSCLLGMAL 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 254 LLINVFNIRGGGYMYFITYVLqGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTvKIYYYTNLLLAALAVLMWFLPSGP 333
Cdd:PRK10429 242 AYNIASNIINGFAIYYFTYVI-GDADLFPYYLSYAGAANLVTLILFPRLVKSLSR-RILWAGASIFPVLSCGVLLLMGLA 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 334 AYQTLWLAVILGNGVILGFTLPLHFSLMAFAD--DYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPG 411
Cdd:PRK10429 320 APHNALLIVIAGILLNIGTALFWVLQVIMVADtvDYGEYKLGIRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGYVPN 399
                        410
                 ....*....|....*
gi 446126955 412 VEnQTASSLGGIAAM 426
Cdd:PRK10429 400 VE-QSAQTLLGMQFI 413
PRK09848 PRK09848
glucuronide transporter; Provisional
20-465 2.73e-42

glucuronide transporter; Provisional


Pssm-ID: 182109 [Multi-domain]  Cd Length: 448  Bit Score: 155.71  E-value: 2.73e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  20 LSVREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRWGRFRPWQLW 99
Cdd:PRK09848   5 LSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRPFLLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 100 IAIPIGIIGILTFTVP-DASMGVKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLCGVAGFLVSV 178
Cdd:PRK09848  85 GTAPLMIFSVLVFWVPtDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFVCLAF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 179 GLPWMVDLFGQGNAARGYQLGVGVLCAIAVVMFLCCFFWVRERVPLStMGKFTLREHLAGLRNNDQLLLMLVMSFL-LIN 257
Cdd:PRK09848 165 LIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRI-VAQPSLKISLQTLKRNRPLFMLCIGALCvLIS 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 258 VFNIRGGGyMYFITYVLqgstGYTSLFFTMVTFASIIGSVIVSP----LTRRFDTVKIYYYTNLLLAALAVLMWFLpsgP 333
Cdd:PRK09848 244 TFAVSASS-LFYVRYVL----NDTGLFTVLVLVQNLVGTVASAPlvpgMVARIGKKNTFLIGALLGTCGYLLFFWV---S 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 334 AYQTLWLAVILGNGVI-LGFTLPLHFSLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGv 412
Cdd:PRK09848 316 VWSLPVALVALAIASIgQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIAN- 394
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446126955 413 ENQTASSLGGIAAMETLLPALFHLLLAGAIRFCKLNNPMMSRIATDLRQRHVQ 465
Cdd:PRK09848 395 QVQTPEVIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEIDNRKKV 447
MFS_MFSD2 cd17392
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ...
25-415 2.52e-14

Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340950  Cd Length: 446  Bit Score: 74.81  E-value: 2.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQ-SRWGRFRPWQLWIAIP 103
Cdd:cd17392    1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQrTGIGRLMPWIVFSTPL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 104 IGIIGILTFTVPDASMGvKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRF------VLCG--VAGFL 175
Cdd:cd17392   81 IILAYFFLWFLPPFTSL-SGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRMtvevfgTLMGatIQGQI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 176 VSVG-LPWMVDLFGQG-----------NAARGYQLGVGVlcaIAVVMFLCC---FFWVRERV-PLSTMGKFTLrEHLAGL 239
Cdd:cd17392  160 VGVAhRPRRQDCTATPgtsdhpvtvlpNTRRAYLIAALV---VVVLYFVCCsilFLGVKEQPdPLSPASGPGL-SYLAGL 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 240 R--NNDQLLLMLVMSFLLINV-FNIRGGGYMYFITYVLQGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTN 316
Cdd:cd17392  236 KlvTGHPPYLKLVIGFLFSSLaFQMEQGNFVLFCTHAAGLGDHFQHLVLAILVSATLSIPLWQWVLQRRGKKTTSFIGIS 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 317 LLLAALAVLMWFLPSGPAYqtLWLAVILGNGVILGFTLPlhFSLMafADDYGEWKTRVRS----SGMNFAFNLFFIKLAW 392
Cdd:cd17392  316 AMVPFLILLALVPSNLPVA--YVVAVVSGVSLAALFLLP--WSML--PDVVDDFQLKNPHcpglEPIFYSCYVFFTKLGG 389
                        410       420
                 ....*....|....*....|...
gi 446126955 393 ASSAGIISLLFIFVAYQPGVENQ 415
Cdd:cd17392  390 GLSLGISTLSLHFSGYKAGACKQ 412
MFS_NLS1_MFSD2A cd17451
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ...
25-415 1.15e-12

Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341009  Cd Length: 419  Bit Score: 69.46  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQ-SRWGRFRPWQLWIAIP 103
Cdd:cd17451    1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPwTRFGRLMPWIIFSTPF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 104 IGIIGILTFTVPDASMGvKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLcGVAGFLVSVGLPwm 183
Cdd:cd17451   81 AVLSYFLIWFVPDFSQG-KVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTV-EVLGTVLGTAIQ-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 184 vdlfGQGNAARGYQLGVGVLCAIAVVMFLCCFFWVRERVPLSTMGKFTLREHLAGLRnndqlLLM-------LVMSFLLI 256
Cdd:cd17451  157 ----GQIVGMAAYMIAAGVICAIYVLCAIILFLGVREQREPCELKSQKPVSFFKGLK-----LVMshgpyikLITGFLFT 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 257 NV-FNIRGGGYMYFITYVLQGSTGYTSLFFTMVTFASIIGSVIVSPLTrRFDTVKIYYYTNLLLAALAVLMWFLPSGPAY 335
Cdd:cd17451  228 SLaFMLLEGNFALFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLT-RFGKKTAVYIGISSAVPFLILVVLVESNLIV 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 336 qTLWLAVILGNGVILGFTLPLHFsLMAFADDYG-EWKTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFIFVAYQPGVEN 414
Cdd:cd17451  307 -TYVVSVAAGVSVAAAFLLPWSM-LPDVVDDFKlKNPDSQGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCS 384

                 .
gi 446126955 415 Q 415
Cdd:cd17451  385 Q 385
MFS_MFSD2B cd17452
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ...
25-418 2.53e-12

Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341010  Cd Length: 416  Bit Score: 68.31  E-value: 2.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQ-SRWGRFRPWQLWIAIP 103
Cdd:cd17452    1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKwTKIGRLMPWMLGCTPF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 104 IGIIGILTFTVPDASMGvKIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRFVLcGVAGFLVSVGLpwm 183
Cdd:cd17452   81 IVVSYFFLWFVPPFTTG-RFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTV-EVLGTLVGAAV--- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 184 vdlfgQGN-AARGYQLGVGVLCAIAVVMFLCCFFWVRERVPLSTMGKFTLREHLAGLRNNDQL--LLMLVMSFLLINV-F 259
Cdd:cd17452  156 -----QGQiVASAYMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAIPFFKGLSLTMRHgpYLKLTASFLFISAaV 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 260 NIRGGGYMYFITYVLQGSTGYTSLFFTMvtfasIIGSVIVSPLTRRF---DTVKIYYYTNLLLAALAVLMWFLPSGP-AY 335
Cdd:cd17452  231 QLEQSNFVLFCTHAVDLHDHFQNLVLTI-----LVSAVVSIPFWQWFlqrFGKKAAACGISWMIPFAIMLVTIPNLIvAY 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 336 qtlwlAVILGNGVILGFTLPLHFSLMAFADDYGEWKTRvRSSGMN---FAFNLFFIKLAWASSAGIISLLFIFVAYQPGV 412
Cdd:cd17452  306 -----VVAFVSGLSIAASLLLPWSMLPDVVDDFRLQNP-HGKGLEtifYSSYVFFTKLSAGIALGISTLSLEFAGYETGA 379

                 ....*.
gi 446126955 413 ENQTAS 418
Cdd:cd17452  380 CKQPES 385
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
23-345 2.10e-06

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 49.77  E-value: 2.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  23 REKIGYGLGDAGGTVITCLIMNFL-TFFYTDVFGLTPALVGTLFIAL-----RVFDAISDPVMGVIADRTqsrwGRFRPW 96
Cdd:COG2270   10 REILAWALYDWANSAFSTVITTFVfPPYFTSVAALGDPAAATALWGYalaiaGLLVALLAPVLGAIADRS----GRKKPF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  97 -QLWIAIPIGIIGILTFTVPDAsmgvkIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHN-EVISCQSWRFVLCG-VAG 173
Cdd:COG2270   86 lAFFTLLGVLATAALFFVAPGG-----LWLGLLLFVLANIGFEGSLVFYNAFLPDIATPEEiGRVSGLGWALGYLGgVLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 174 FLVSVGLPWMVDLFGQGNAARGYQLgVGVLCAIAVVMF-LCCFFWVRERVPLSTMGKFT--------LREHLAGLRNNDQ 244
Cdd:COG2270  161 LLINLALFLKPEAFGLPDAGEAVRI-SFLLTALWWLLFaLPLFLFLPERPRPGPAPPRGavragfreLRRTLRELRRYRD 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 245 LLLMLVMSFLLINVFN--IRGGGYmyFITYVLQGSTGYTSLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAAL 322
Cdd:COG2270  240 LLRFLLAYFFYRDGVQtvIAFAGI--YAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVV 317
                        330       340
                 ....*....|....*....|...
gi 446126955 323 AVLMWFLPSgpAYQTLWLAVILG 345
Cdd:COG2270  318 CLAAYFLTT--ALAFWILGLLIG 338
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
50-404 4.17e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.41  E-value: 4.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  50 YTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTqsrwgRFRPWQLWIAIPIGIIGILTFTVPDasmgvkIAWAFGT 129
Cdd:cd06174   22 LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-----GRRPVLLLGLLLFALGALLFAFAPS------FWLLLLG 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 130 YLLLSVGYTAINVPYCALINTMTTRHnEVISCQSWRFVLCGVAGFLVSVGLPWMVDLFGQgnaarGYQLGVGVLCAIAVV 209
Cdd:cd06174   91 RFLLGLGSGLIDPAVLALIADLFPER-ERGRALGLLQAFGSVGGILGPLLGGILASSLGF-----GWRAVFLIAAALALL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 210 MFLCCFFWVRERVPLSTMGKF-----TLREHLAGLRNNDQLLLMLVMSFLLINVFNIRGGGYMYFITYVLQGSTGYTSLF 284
Cdd:cd06174  165 AAILLLLVVPDPPESARAKNEeasskSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLL 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 285 FTMVTFASIIGSVIVSPLTRRFDTVKIYYYTnllLAALAVLMWFLPSGPAYQTLWLAVILGNGVILGFTLPLHFSLMAFA 364
Cdd:cd06174  245 LSLFGLAGALGSLLLGLLSDRLIGRKPLLLI---GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 446126955 365 ddygewkTRVRSSGMNFAFNLFFIKLAWASSAGIISLLFI 404
Cdd:cd06174  322 -------FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA 354
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
42-391 1.32e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.73  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  42 IMNFLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRtqsrWGRfRPWQLWIAIPIGIIGILTFTVPDasmgv 121
Cdd:COG2814   28 IVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR----FGR-RRVLLLGLLLFALGSLLCALAPS----- 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 122 kIAWAFGTYLLLSVGYTAINVPYCALINTMTTRHN--EVISCQSWRFVLCGVAGFLVSvglPWMVDLFGqgnaargYQLG 199
Cdd:COG2814   98 -LWLLLAARFLQGLGAGALFPAALALIADLVPPERrgRALGLLGAGLGLGPALGPLLG---GLLADLFG-------WRWV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 200 VGVLCAIAVVMFLCCFFWVRERVPlstMGKFTLREHLAGLRNNDQLLLMLVMSFLlinvFNIRGGGYMYFITYVLQGSTG 279
Cdd:COG2814  167 FLVNAVLALLALLLLLRLLPESRP---AARARLRGSLRELLRRPRLLLLLLLAFL----LGFGFFALFTYLPLYLQEVLG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955 280 YT----SLFFTMVTFASIIGSVIVSPLTRRFDTVKIYYYTNLLLAALAVLMWFLPSGPAYqtlwLAVILGNGVILGFTLP 355
Cdd:COG2814  240 LSasaaGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLL----LLALFLLGFGFGLLFP 315
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 446126955 356 LhfsLMAFADDYGEWKTRVRSSGMNFAFNLFFIKLA 391
Cdd:COG2814  316 L---LQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_MFSD12 cd17491
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ...
45-192 1.77e-03

Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341044  Cd Length: 438  Bit Score: 40.70  E-value: 1.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446126955  45 FLTFFYTDVFGLTPALVGTLFIALRVFDAISDPVMGVIADRTQSRW--GRFRPWQLWIAIPIGIIGILTFTVPDASMGVK 122
Cdd:cd17491   21 YLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTNGCGkyGRRKSWHLIGTICVLLSFPFIFNPCLGCSDST 100
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446126955 123 IAWAFGTY-----LLLSVGYTAINVPYCALINTMTTRHNEVISCQSWRF---VLCGVAGFLVSvglpWMvdLFGQGNA 192
Cdd:cd17491  101 SEWAKLVYygpfiIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYaftVIANITVYLIA----WL--LLQQSSG 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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