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Conserved domains on  [gi|446133877|ref|WP_000211732|]
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MULTISPECIES: class I SAM-dependent methyltransferase [Escherichia]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 34-161 1.90e-39

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 133.58  E-value: 1.90e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  34 QRLAERLADYPDASVLDMGCGAGHASFVAAQNVSAVVAYDLSAQMLDVVAQAAEARQLkNITTRQGYAESLPFADNAFDI 113
Cdd:COG2226   12 EALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSFDL 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446133877 114 VISRYSAHHWHDVGAALREVNRVLKPGGMLIVMDIMSPGHPVRDIWLQ 161
Cdd:COG2226   91 VISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLA 138
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 34-161 1.90e-39

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 133.58  E-value: 1.90e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  34 QRLAERLADYPDASVLDMGCGAGHASFVAAQNVSAVVAYDLSAQMLDVVAQAAEARQLkNITTRQGYAESLPFADNAFDI 113
Cdd:COG2226   12 EALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSFDL 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446133877 114 VISRYSAHHWHDVGAALREVNRVLKPGGMLIVMDIMSPGHPVRDIWLQ 161
Cdd:COG2226   91 VISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLA 138
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-145 2.93e-31

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 111.22  E-value: 2.93e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   49 LDMGCGAGHASFVAAQNVSAVVAYDLSAQMLDVVAQAAEARQLkniTTRQGYAESLPFADNAFDIVISRYSAHHWHDVGA 128
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGL---TFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPER 77

                          90
                  ....*....|....*..
gi 446133877  129 ALREVNRVLKPGGMLIV 145
Cdd:pfam08241  78 ALREIARVLKPGGILII 94
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 1-163 2.20e-23

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 94.83  E-value: 2.20e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   1 MTTQSHHDHVEKQFSSQASEY-LTSTVHTSGRDL---QRLAERLADYPDASVLDMGCGAGHASFVAAQNVSA---VVAYD 73
Cdd:PRK00216   4 VAEEEKQEKVAEMFDSIAPKYdLMNDLLSFGLHRvwrRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKtgeVVGLD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  74 LSAQMLDVVAQAAEARQL-KNITTRQGYAESLPFADNAFDIV-ISrYSAHHWHDVGAALREVNRVLKPGGMLIVMDIMSP 151
Cdd:PRK00216  84 FSEGMLAVGREKLRDLGLsGNVEFVQGDAEALPFPDNSFDAVtIA-FGLRNVPDIDKALREMYRVLKPGGRLVILEFSKP 162

                        170
                 ....*....|....*.
gi 446133877 152 GHP----VRDIWLQTV 163
Cdd:PRK00216 163 TNPplkkAYDFYLFKV 178
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 10-163 1.06e-21

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 90.01  E-value: 1.06e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   10 VEKQFSSQASEY-LTSTVHTSGRDL---QRLAERLADYPDASVLDMGCGAGHASFVAAQNVSA---VVAYDLSAQMLDVV 82
Cdd:TIGR01934   1 VQEMFDRIAPKYdLLNDLLSFGLHRlwrRRAVKLIGVFKGQKVLDVACGTGDLAIELAKSAPDrgkVTGVDFSSEMLEVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   83 AQAAEARQlkNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRVLKPGGMLIVMDIMSPGH----PVRDI 158
Cdd:TIGR01934  81 KKKSELPL--NIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEFSKPANallkKFYKF 158


                  ....*
gi 446133877  159 WLQTV 163
Cdd:TIGR01934 159 YLKNV 163
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 48-146 1.82e-17

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 75.54  E-value: 1.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  48 VLDMGCGAGHASFVAAQNVSA-VVAYDLSAQMLDVVAQAAEARQLKNITTRQGYAESLPF-ADNAFDIVISRYSAHHWH- 124
Cdd:cd02440    2 VLDLGCGTGALALALASGPGArVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPLHHLVe 81

                         90       100
                 ....*....|....*....|..
gi 446133877 125 DVGAALREVNRVLKPGGMLIVM 146
Cdd:cd02440   82 DLARFLEEARRLLKPGGVLVLT 103
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
47-196 2.59e-07

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 50.11  E-value: 2.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877    47 SVLDMGCGAGHASFVAAQNVS--AVVAYDLSAQMLDVVAQAAEARQLKN-ITTRQGYAESLPFADNaFDIVISRYSAHHW 123
Cdd:smart00828   2 RVLDFGCGYGSDLIDLAERHPhlQLHGYTISPEQAEVGRERIRALGLQGrIRIFYRDSAKDPFPDT-YDLVFGFEVIHHI 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446133877   124 HDVGAALREVNRVLKPGGMLIVMDIMSPG-----HPVRDIWLQTVEalrdtshvrnyacgEWLALINEANLIVDNLIT 196
Cdd:smart00828  81 KDKMDLFSNISRHLKDGGHLVLADFIANLlsaieHEETTSYLVTRE--------------EWAELLARNNLRVVEGVD 144
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 34-161 1.90e-39

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 133.58  E-value: 1.90e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  34 QRLAERLADYPDASVLDMGCGAGHASFVAAQNVSAVVAYDLSAQMLDVVAQAAEARQLkNITTRQGYAESLPFADNAFDI 113
Cdd:COG2226   12 EALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSFDL 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446133877 114 VISRYSAHHWHDVGAALREVNRVLKPGGMLIVMDIMSPGHPVRDIWLQ 161
Cdd:COG2226   91 VISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLA 138
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-145 2.93e-31

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 111.22  E-value: 2.93e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   49 LDMGCGAGHASFVAAQNVSAVVAYDLSAQMLDVVAQAAEARQLkniTTRQGYAESLPFADNAFDIVISRYSAHHWHDVGA 128
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGL---TFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPER 77

                          90
                  ....*....|....*..
gi 446133877  129 ALREVNRVLKPGGMLIV 145
Cdd:pfam08241  78 ALREIARVLKPGGILII 94
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-141 2.95e-29

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 106.11  E-value: 2.95e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   48 VLDMGCGAGHASFVAAQNVSA-VVAYDLSAQMLDVVAQAAEARQLkNITTRQGYAESLPFADNAFDIVISRYSAHHWH-- 124
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGArVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPdp 79

                          90
                  ....*....|....*..
gi 446133877  125 DVGAALREVNRVLKPGG 141
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 31-148 7.16e-27

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 100.86  E-value: 7.16e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  31 RDLQRLAERLADyPDASVLDMGCGAGHASFVAAQNVSAVVAYDLSAQMLDVVAQAAEARqlkNITTRQGYAESLPFADNA 110
Cdd:COG2227   12 RRLAALLARLLP-AGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAEL---NVDFVQGDLEDLPLEDGS 87

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446133877 111 FDIVISRYSAHHWHDVGAALREVNRVLKPGGMLIVMDI 148
Cdd:COG2227   88 FDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTP 125
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 1-163 2.20e-23

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 94.83  E-value: 2.20e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   1 MTTQSHHDHVEKQFSSQASEY-LTSTVHTSGRDL---QRLAERLADYPDASVLDMGCGAGHASFVAAQNVSA---VVAYD 73
Cdd:PRK00216   4 VAEEEKQEKVAEMFDSIAPKYdLMNDLLSFGLHRvwrRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKtgeVVGLD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  74 LSAQMLDVVAQAAEARQL-KNITTRQGYAESLPFADNAFDIV-ISrYSAHHWHDVGAALREVNRVLKPGGMLIVMDIMSP 151
Cdd:PRK00216  84 FSEGMLAVGREKLRDLGLsGNVEFVQGDAEALPFPDNSFDAVtIA-FGLRNVPDIDKALREMYRVLKPGGRLVILEFSKP 162

                        170
                 ....*....|....*.
gi 446133877 152 GHP----VRDIWLQTV 163
Cdd:PRK00216 163 TNPplkkAYDFYLFKV 178
PRK08317 PRK08317
hypothetical protein; Provisional
 34-147 1.28e-22

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 92.69  E-value: 1.28e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  34 QRLAERLADYPDASVLDMGCGAGHASFVAAQNVSA---VVAYDLSAQMLDVVAQAAEArQLKNITTRQGYAESLPFADNA 110
Cdd:PRK08317   9 ARTFELLAVQPGDRVLDVGCGPGNDARELARRVGPegrVVGIDRSEAMLALAKERAAG-LGPNVEFVRGDADGLPFPDGS 87

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446133877 111 FDIVISRYSAHHWHDVGAALREVNRVLKPGGMLIVMD 147
Cdd:PRK08317  88 FDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLD 124
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 10-163 1.06e-21

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 90.01  E-value: 1.06e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   10 VEKQFSSQASEY-LTSTVHTSGRDL---QRLAERLADYPDASVLDMGCGAGHASFVAAQNVSA---VVAYDLSAQMLDVV 82
Cdd:TIGR01934   1 VQEMFDRIAPKYdLLNDLLSFGLHRlwrRRAVKLIGVFKGQKVLDVACGTGDLAIELAKSAPDrgkVTGVDFSSEMLEVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   83 AQAAEARQlkNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRVLKPGGMLIVMDIMSPGH----PVRDI 158
Cdd:TIGR01934  81 KKKSELPL--NIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEFSKPANallkKFYKF 158


                  ....*
gi 446133877  159 WLQTV 163
Cdd:TIGR01934 159 YLKNV 163
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 44-148 1.14e-19

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 82.46  E-value: 1.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   44 PDASVLDMGCGAGHASFVAAQNV---SAVVAYDLSAQMLDVVAQAAEARQLKNITTRQGYAESLP--FADNAFDIVISRY 118
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELgpnAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPelLEDDKFDVVISNC 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 446133877  119 SAHHWHDVGAALREVNRVLKPGGMLIVMDI 148
Cdd:pfam13847  83 VLNHIPDPDKVLQEILRVLKPGGRLIISDP 112
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 44-145 8.15e-19

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 81.50  E-value: 8.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  44 PDASVLDMGCGAG-HASFVAAQNVSAVVAYDLSAQMLDVVAQAAEARQLKNITTRQG-YAESLPFADNAFDIVISRYSAH 121
Cdd:COG0500   26 KGGRVLDLGCGTGrNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVAdLAELDPLPAESFDLVVAFGVLH 105

                         90       100
                 ....*....|....*....|....*.
gi 446133877 122 HW--HDVGAALREVNRVLKPGGMLIV 145
Cdd:COG0500  106 HLppEEREALLRELARALKPGGVLLL 131
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 33-145 9.20e-18

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 77.66  E-value: 9.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  33 LQRLAERLADYPDASVLDMGCGAGHASFVAAQNVSA-VVAYDLSAQMLDVVAQAAEARQLKN-ITTRQGYAESLPfADNA 110
Cdd:COG2230   40 LDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVrVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYRDLP-ADGQ 118

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446133877 111 FDIVISRYSAHH--WHDVGAALREVNRVLKPGGMLIV 145
Cdd:COG2230  119 FDAIVSIGMFEHvgPENYPAYFAKVARLLKPGGRLLL 155
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
10-154 1.21e-17

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 79.02  E-value: 1.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   10 VEKQFSSQASEY------LTSTVHTSGRDlqRLAERLADYPDASVLDMGCGAGHASFVAAQNVSA---VVAYDLSAQMLD 80
Cdd:pfam01209   4 VGDVFSSVASKYdlmndvISFGIHRLWKD--FTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSAGSsgkVVGLDINENMLK 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446133877   81 VVAQAAEARQLKNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRVLKPGGMLIVMDIMSPGHP 154
Cdd:pfam01209  82 EGEKKAKEEGKYNIEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLEFSKPENP 155
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 48-146 1.82e-17

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 75.54  E-value: 1.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  48 VLDMGCGAGHASFVAAQNVSA-VVAYDLSAQMLDVVAQAAEARQLKNITTRQGYAESLPF-ADNAFDIVISRYSAHHWH- 124
Cdd:cd02440    2 VLDLGCGTGALALALASGPGArVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPLHHLVe 81

                         90       100
                 ....*....|....*....|..
gi 446133877 125 DVGAALREVNRVLKPGGMLIVM 146
Cdd:cd02440   82 DLARFLEEARRLLKPGGVLVLT 103
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
5-195 1.84e-17

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 77.35  E-value: 1.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   5 SHHDHVEKQFSSQASEYLTSTVHTSGRD-----LQRLAERLADYPDASVLDMGCGAGHASFVAAQNVSAVVAYDLSAQML 79
Cdd:COG4976    2 ALDAYVEALFDQYADSYDAALVEDLGYEapallAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEML 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  80 DVvaqaAEARQLKnITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRVLKPGGMLIVmdimspghpvrdiw 159
Cdd:COG4976   82 AK----AREKGVY-DRLLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIF-------------- 142

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 446133877 160 lqTVEALrDTSHVRNYACGEWLALINEANLIVDNLI 195
Cdd:COG4976  143 --SVEDA-DGSGRYAHSLDYVRDLLAAAGFEVPGLL 175
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
44-145 1.05e-16

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 73.32  E-value: 1.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  44 PDASVLDMGCGAGHASFVAAQNVSA--VVAYDLSAQMLdvvaqaAEARQ-LKNITTRQGYAESLPFADNaFDIVISRYSA 120
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGarVTGVDLSPEML------ARARArLPNVRFVVADLRDLDPPEP-FDLVVSNAAL 73

                         90       100
                 ....*....|....*....|....*
gi 446133877 121 HHWHDVGAALREVNRVLKPGGMLIV 145
Cdd:COG4106   74 HWLPDHAALLARLAAALAPGGVLAV 98
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 33-211 1.37e-16

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 76.56  E-value: 1.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   33 LQRLAERLADYPdASVLDMGCGAGHASFVAAQ--NVSAVVAYDLSAQMLdvvAQAAEARQlKNITTRQGYAESLPFADNA 110
Cdd:TIGR02072  24 LALLKEKGIFIP-ASVLDIGCGTGYLTRALLKrfPQAEFIALDISAGML---AQAKTKLS-ENVQFICGDAEKLPLEDSS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  111 FDIVISRySAHHW-HDVGAALREVNRVLKPGGMLIVMDImSPG--HPVRDIWLQTVEALRDTShvrnyacgEWLALINEA 187
Cdd:TIGR02072  99 FDLIVSN-LALQWcDDLSQALSELARVLKPGGLLAFSTF-GPGtlHELRQSFGQHGLRYLSLD--------ELKALLKNS 168

                         170       180
                  ....*....|....*....|....
gi 446133877  188 NLIVDnLITDKLPLEFSSWVARMR 211
Cdd:TIGR02072 169 FELLT-LEEELITLSFDDPLDVLR 191
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-143 6.18e-16

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 71.24  E-value: 6.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   49 LDMGCGAGHASFVAAQNV--SAVVAYDLSAQMLDVVAQAAEARQLKNITTRQGYAESLPFAD-NAFDIVISRYSAHHWHD 125
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALpgLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDpGSFDVVVASNVLHHLAD 80

                          90
                  ....*....|....*...
gi 446133877  126 VGAALREVNRVLKPGGML 143
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGVL 98
arsM PRK11873
arsenite methyltransferase;
48-148 9.04e-16

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 74.60  E-value: 9.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  48 VLDMGCGAGHASFVAAQNVSA---VVAYDLSAQMLDVVAQAAEARQLKNITTRQGYAESLPFADNAFDIVISRYSAHHWH 124
Cdd:PRK11873  81 VLDLGSGGGFDCFLAARRVGPtgkVIGVDMTPEMLAKARANARKAGYTNVEFRLGEIEALPVADNSVDVIISNCVINLSP 160

                         90       100
                 ....*....|....*....|....
gi 446133877 125 DVGAALREVNRVLKPGGMLIVMDI 148
Cdd:PRK11873 161 DKERVFKEAFRVLKPGGRFAISDV 184
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 32-143 1.20e-14

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 71.33  E-value: 1.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  32 DLQR-----LAERLADYPDASVLDMGCGAGHASFVAAQNVSAVVAYDLSAQMLdvvaqaAEARQlKNITTR--QGYAESL 104
Cdd:PRK10258  25 ELQRqsadaLLAMLPQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPML------AQARQ-KDAADHylAGDIESL 97

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446133877 105 PFADNAFDIVISRYSAHHWHDVGAALREVNRVLKPGGML 143
Cdd:PRK10258  98 PLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVV 136
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 31-189 7.41e-13

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 64.76  E-value: 7.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   31 RDLQRLAERLADYP--DASVLDMGCGAGHASFVAAQNVSAVVAYDLSAqmldvvaqAAEARQLKNITTRQGYAESLPFAD 108
Cdd:pfam13489   7 RLLADLLLRLLPKLpsPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSP--------IAIERALLNVRFDQFDEQEAAVPA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  109 NAFDIVISRYSAHHWHDVGAALREVNRVLKPGGMLIVMDIMSPGHpvRDIWLQTVEALRDTS-HVRNYACGEWLALINEA 187
Cdd:pfam13489  79 GKFDVIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPLASDE--ADRLLLEWPYLRPRNgHISLFSARSLKRLLEEA 156


                  ..
gi 446133877  188 NL 189
Cdd:pfam13489 157 GF 158
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 48-155 7.98e-12

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 63.37  E-value: 7.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  48 VLDMGCGAGHASFVAAQNVSA---VVAYDLSAQMLDVVA--QAAEARQ-LKNITTRQGYAESLPFADNAFDIVISRYSAH 121
Cdd:PLN02233  77 VLDLCCGSGDLAFLLSEKVGSdgkVMGLDFSSEQLAVAAsrQELKAKScYKNIEWIEGDATDLPFDDCYFDAITMGYGLR 156

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446133877 122 HWHDVGAALREVNRVLKPGGMLIVMDIMSPGHPV 155
Cdd:PLN02233 157 NVVDRLKAMQEMYRVLKPGSRVSILDFNKSTQPF 190
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 44-160 2.90e-10

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 59.52  E-value: 2.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  44 PDASVLDMGCGAGHASFVAAQNVSA--VVAYDLSAQMLdvvAQAAEARQLKNITTRQGYAESLPFADNAFDIVISRYSAH 121
Cdd:PLN02490 113 RNLKVVDVGGGTGFTTLGIVKHVDAknVTILDQSPHQL---AKAKQKEPLKECKIIEGDAEDLPFPTDYADRYVSAGSIE 189

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446133877 122 HWHDVGAALREVNRVLKPGGMLIVMDIMSPGHPVR----DIWL 160
Cdd:PLN02490 190 YWPDPQRGIKEAYRVLKIGGKACLIGPVHPTFWLSrffaDVWM 232
PRK05785 PRK05785
hypothetical protein; Provisional
 47-136 6.56e-10

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 57.39  E-value: 6.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  47 SVLDMGCGAGHASFVAAQNVSA-VVAYDLSAQMLDVVAQAAEarqlknitTRQGYAESLPFADNAFDIVISRYSAHHWHD 125
Cdd:PRK05785  54 KVLDVAAGKGELSYHFKKVFKYyVVALDYAENMLKMNLVADD--------KVVGSFEALPFRDKSFDVVMSSFALHASDN 125

                         90
                 ....*....|.
gi 446133877 126 VGAALREVNRV 136
Cdd:PRK05785 126 IEKVIAEFTRV 136
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 44-154 2.54e-09

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 57.07  E-value: 2.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  44 PDASVLDMGCGAGHASFVAAQNVSA-VVAYDLSAQMLDVVAQAAEAR------QLKNITTRQgyaeslpFADNAFDIVIS 116
Cdd:PLN02336 266 PGQKVLDVGCGIGGGDFYMAENFDVhVVGIDLSVNMISFALERAIGRkcsvefEVADCTKKT-------YPDNSFDVIYS 338

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446133877 117 RYSAHHWHDVGAALREVNRVLKPGGMLIVMD-IMSPGHP 154
Cdd:PLN02336 339 RDTILHIQDKPALFRSFFKWLKPGGKVLISDyCRSPGTP 377
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 36-145 6.69e-08

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 51.34  E-value: 6.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  36 LAERLADYPDASVLDMGCGAGH-ASFVAAQNVSA-VVAYDLSAQMLDVVAQAAEARQLKNITTRQGYAESlPFADNAFDI 113
Cdd:COG2813   41 LLEHLPEPLGGRVLDLGCGYGViGLALAKRNPEArVTLVDVNARAVELARANAAANGLENVEVLWSDGLS-GVPDGSFDL 119

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446133877 114 VIS----RYSAHHWHDVGAAL-REVNRVLKPGGMLIV 145
Cdd:COG2813  120 ILSnppfHAGRAVDKEVAHALiADAARHLRPGGELWL 156
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
104-145 7.82e-08

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 50.64  E-value: 7.82e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 446133877 104 LPFADNAFDIVisrYSAH---H--WHDVGAALREVNRVLKPGGMLIV 145
Cdd:COG4627   40 LPFPDNSVDAI---YSSHvleHldYEEAPLALKECYRVLKPGGILRI 83
PLN02244 PLN02244
tocopherol O-methyltransferase
 48-145 1.67e-07

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 51.28  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  48 VLDMGCGAGHASFVAAQNVSAVV-AYDLSAqmldvvAQAAEARqlkNITTRQGYAE----------SLPFADNAFDIVIS 116
Cdd:PLN02244 122 IVDVGCGIGGSSRYLARKYGANVkGITLSP------VQAARAN---ALAAAQGLSDkvsfqvadalNQPFEDGQFDLVWS 192

                         90       100
                 ....*....|....*....|....*....
gi 446133877 117 RYSAHHWHDVGAALREVNRVLKPGGMLIV 145
Cdd:PLN02244 193 MESGEHMPDKRKFVQELARVAAPGGRIII 221
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
47-196 2.59e-07

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 50.11  E-value: 2.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877    47 SVLDMGCGAGHASFVAAQNVS--AVVAYDLSAQMLDVVAQAAEARQLKN-ITTRQGYAESLPFADNaFDIVISRYSAHHW 123
Cdd:smart00828   2 RVLDFGCGYGSDLIDLAERHPhlQLHGYTISPEQAEVGRERIRALGLQGrIRIFYRDSAKDPFPDT-YDLVFGFEVIHHI 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446133877   124 HDVGAALREVNRVLKPGGMLIVMDIMSPG-----HPVRDIWLQTVEalrdtshvrnyacgEWLALINEANLIVDNLIT 196
Cdd:smart00828  81 KDKMDLFSNISRHLKDGGHLVLADFIANLlsaieHEETTSYLVTRE--------------EWAELLARNNLRVVEGVD 144
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 47-148 5.37e-07

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273910  Cd Length: 224  Bit Score: 49.22  E-value: 5.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   47 SVLDMGCGAGHASFVAAQNVSAVVAYDLSAQMLDVVAQAAEARQLkNITTRQGYAESLPFADN-AFDIVISRYSAHHWHD 125
Cdd:TIGR01983  49 RVLDVGCGGGLLSEPLARLGANVTGIDASEENIEVAKLHAKKDPL-QIDYRCTTVEDLAEKKAgSFDVVTCMEVLEHVPD 127

                          90       100
                  ....*....|....*....|...
gi 446133877  126 VGAALREVNRVLKPGGMLIVMDI 148
Cdd:TIGR01983 128 PQAFIRACAQLLKPGGILFFSTI 150
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 29-152 1.62e-06

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 47.98  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  29 SGRDLQRLAERLADYPdASVLDMGCGAGHASFVAAQNVSAVVAYDLsaQMLDV--VAQAAEARQLKNITTRQGYAESLPF 106
Cdd:PRK11088  71 RDAVANLLAERLDEKA-TALLDIGCGEGYYTHALADALPEITTMQL--FGLDIskVAIKYAAKRYPQVTFCVASSHRLPF 147

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446133877 107 ADNAFDIVISRYSAhhwhdvgAALREVNRVLKPGGMLIVmdiMSPG 152
Cdd:PRK11088 148 ADQSLDAIIRIYAP-------CKAEELARVVKPGGIVIT---VTPG 183
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 30-115 1.88e-06

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 47.52  E-value: 1.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  30 GRD--LQRLAERLADYPD---ASVLDMGCGAGHASFVAAQNVSAVVAYDLSAQMLDVVAQ-AAEARQLKNITTRQGYAES 103
Cdd:PRK07580  44 GHQrmRDTVLSWLPADGDltgLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARErAPEAGLAGNITFEVGDLES 123

                         90
                 ....*....|..
gi 446133877 104 LpfaDNAFDIVI 115
Cdd:PRK07580 124 L---LGRFDTVV 132
PRK14968 PRK14968
putative methyltransferase; Provisional
 36-141 3.47e-06

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 46.43  E-value: 3.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  36 LAERLADYPDASVLDMGCGAGHASFVAAQNVSAVVAYDLSAqmlDVVAQAAEARQLKNITTR--QGYAESL--PFADNAF 111
Cdd:PRK14968  15 LAENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINP---YAVECAKCNAKLNNIRNNgvEVIRSDLfePFRGDKF 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446133877 112 DIVI--------------SRYSAHHWhDVGAA--------LREVNRVLKPGG 141
Cdd:PRK14968  92 DVILfnppylpteeeeewDDWLNYAL-SGGKDgrevidrfLDEVGRYLKPGG 142
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 44-146 3.96e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 45.71  E-value: 3.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  44 PDASVLDMGCGAGhaSF-VAAQNVSA-VVAYDLSAQMLDVVAQAAEARQLKNITTRQGYAESLPFADNAFDIVIS----- 116
Cdd:COG1041   26 EGDTVLDPFCGTG--TIlIEAGLLGRrVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDLPLADESVDAIVTdppyg 103

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446133877 117 RYSAHHWHD----VGAALREVNRVLKPGGMLIVM 146
Cdd:COG1041  104 RSSKISGEEllelYEKALEEAARVLKPGGRVVIV 137
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 28-146 4.04e-06

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 46.30  E-value: 4.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  28 TSGRDLQRLAER----------LADYPDASVLDMGCGAG-----------HASFVaaqnvsavvaydlsaqMLD------ 80
Cdd:COG0357   41 TAIRDPEELWERhildslallpLLPKEGARVLDVGSGAGfpgiplaiarpDLQVT----------------LVDslgkki 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446133877  81 -VVAQAAEARQLKNITTRQGYAESLPfADNAFDIVISR----------YSAHHwhdvgaalrevnrvLKPGGMLIVM 146
Cdd:COG0357  105 aFLREVVRELGLKNVTVVHGRAEELA-PREKFDVVTARavaplpdlleLALPL--------------LKPGGRLLAL 166
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
32-146 6.97e-06

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 46.11  E-value: 6.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  32 DLQRLAERLADYPdASVLDMGCGAGHASFVAAQNVSAVVAYDLSAQMLDVVAQAAEARQL-KNITTRQGYAESL-PFADN 109
Cdd:PRK11036  33 DLDRLLAELPPRP-LRVLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQRAKQAAEAKGVsDNMQFIHCAAQDIaQHLET 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446133877 110 AFDIVIsrysahhWHDV-------GAALREVNRVLKPGGMLIVM 146
Cdd:PRK11036 112 PVDLIL-------FHAVlewvadpKSVLQTLWSVLRPGGALSLM 148
Methyltransf_29 pfam03141
Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative ...
 48-144 1.02e-05

Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase.


Pssm-ID: 335237 [Multi-domain]  Cd Length: 506  Bit Score: 46.14  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   48 VLDMGCGAghASFVAA---QNVSAvvaydLSAQMLDV-VAQAAEARQ------LKNITTRQgyaesLPFADNAFDIvisr 117
Cdd:pfam03141 121 ALDVGCGV--ASFGAYllsRDVLT-----MSFAPKDVhEAQVQFALErgipamLGVLGTKR-----LPYPSRSFDL---- 184

                          90       100       110
                  ....*....|....*....|....*....|....
gi 446133877  118 ysAH------HWH-DVGAALREVNRVLKPGGMLI 144
Cdd:pfam03141 185 --AHcsrcriPWTaNDGILLLEVDRVLRPGGYFV 216
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 36-145 1.07e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 44.50  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   36 LAERLADYPDASVLDMGCGAGH-ASFVAAQNVSA-VVAYDLSAQMLDVVAQAAEARQLKNITTRQ--GYAEslpFADNAF 111
Cdd:pfam05175  23 LLEHLPKDLSGKVLDLGCGAGVlGAALAKESPDAeLTMVDINARALESARENLAANGLENGEVVAsdVYSG---VEDGKF 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 446133877  112 DIVISR--YSAHHWHDVGAALREVN---RVLKPGG-MLIV 145
Cdd:pfam05175 100 DLIISNppFHAGLATTYNVAQRFIAdakRHLRPGGeLWIV 139
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 33-115 1.80e-05

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 45.17  E-value: 1.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  33 LQRLAERLADYPDASVLDMGCGAGHASFVAAQNVSAVVAYDLSAQMLDVVAQAAEARQLKNITTRQGYAE-SLP--FADN 109
Cdd:COG2265  222 YAAALEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEeVLPelLWGG 301


                 ....*.
gi 446133877 110 AFDIVI 115
Cdd:COG2265  302 RPDVVV 307
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 40-145 4.65e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 43.59  E-value: 4.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  40 LADYPDA----SVLDMGCGAGHASFVAAQNVSA--VVAYDLSAQMldvVAQAAEARQLKNITTR--------QGYAEslP 105
Cdd:COG4123   29 LAAFAPVkkggRVLDLGTGTGVIALMLAQRSPGarITGVEIQPEA---AELARRNVALNGLEDRitvihgdlKEFAA--E 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446133877 106 FADNAFDIVIS-----------------RYSAHH-----WHDVgaaLREVNRVLKPGGMLIV 145
Cdd:COG4123  104 LPPGSFDLVVSnppyfkagsgrkspdeaRAIARHedaltLEDL---IRAAARLLKPGGRFAL 162
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 73-147 6.33e-05

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 42.37  E-value: 6.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446133877  73 DLSAQMLDVVA--QAAEARQ-LKNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRVLKPGGMLIVMD 147
Cdd:PLN02232   4 DFSSEQLAVAAtrQSLKARScYKCIEWIEGDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPGSRVSILD 81
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 33-154 9.21e-05

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 43.02  E-value: 9.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  33 LQRLAERLADYPDASVLDMGCGAGHASFVAAQ---NVSAVVAYDLSAQMLDVVAQAAEARQLKNITTRQGYAESL--PFA 107
Cdd:COG5459   69 LAELAEAGPDFAPLTVLDVGAGPGTAAWAAADawpSLLDATLLERSAAALALGRRLARAAANPALETAEWRLADLaaALP 148

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446133877 108 DNAFDIVISRYS-----AHHWHDVGAALRevnrvLKPGGMLIvmdIMSPGHP 154
Cdd:COG5459  149 APPADLVVASYVlnelaDAARAALVDRLW-----LAPDGALL---IVEPGTP 192
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 34-115 2.75e-04

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 41.02  E-value: 2.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  34 QRLAERLADYPD---ASVLDMGCGAGHASFVAA-QNVSAVVAYDLSAQMLDVVAQAAEARQLKnITTRQGYAESLPfADN 109
Cdd:COG3897   57 QALARYLLDHPEvagKRVLELGCGLGLVGIAAAkAGAADVTATDYDPEALAALRLNAALNGVA-ITTRLGDWRDPP-AAG 134


                 ....*.
gi 446133877 110 AFDIVI 115
Cdd:COG3897  135 GFDLIL 140
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
44-116 3.96e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 40.79  E-value: 3.96e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446133877  44 PDASVLDMGCGAGHASFVAAQ-NVSAVVAYDLSAQMLDVVAQAAEARQLK-NITTRQGYAESLPFaDNAFDIVIS 116
Cdd:COG4076   35 PGDVVLDIGTGSGLLSMLAARaGAKKVYAVEVNPDIAAVARRIIAANGLSdRITVINADATDLDL-PEKADVIIS 108
Methyltransf_9 pfam08003
Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It ...
 29-152 7.27e-04

Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It also includes two putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.


Pssm-ID: 429781 [Multi-domain]  Cd Length: 315  Bit Score: 40.08  E-value: 7.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   29 SGRDLQRLAERLADYPDASVLDMGCGAGHASF-VAAQNVSAVVAYDLSAQMLdvvAQAAEARQLKNITTRqgyAESLPF- 106
Cdd:pfam08003 100 SDWKWDRVLPHLSPLKGRTILDVGCGNGYHMWrMLGEGAAMVVGIDPSELFL---CQFEAVRKLLGNDQR---AHLLPLg 173

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446133877  107 -----ADNAFDIVISRYSAHHWHDVGAALREVNRVLKPGGMLIVMDIMSPG 152
Cdd:pfam08003 174 ieqlpALAAFDTVFSMGVLYHRRSPLDHLLQLKDQLVKGGELVLETLVIDG 224
COG4798 COG4798
Predicted methyltransferase [General function prediction only];
85-147 1.29e-03

Predicted methyltransferase [General function prediction only];


Pssm-ID: 443826  Cd Length: 274  Bit Score: 39.13  E-value: 1.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446133877  85 AAEARQLKNITTRQGYAESLPFA-DNAFDIVISRYSAHHWHDVG---AALREVNRVLKPGGMLIVMD 147
Cdd:COG4798  121 AADPALYGNVRVTAFAPPDDPIApPGSADLVLTFRNYHNWYRAGdaaAMFAAFFKALKPGGVLGVVD 187
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 35-163 2.38e-03

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 38.15  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877  35 RLAERLADYPDASVLDMGCGAGHASFVAAQNVSAVVAYDLSAQMLDVVAQAAEARQLKNITTRQGYAeSLPFADNA-FDI 113
Cdd:COG2518   57 RMLEALDLKPGDRVLEIGTGSGYQAAVLARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDG-ALGWPEHApFDR 135

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446133877 114 VIsrysahhwhdVGAALREVNRV----LKPGGMLIVmdimspghPVRDIWLQTV 163
Cdd:COG2518  136 II----------VTAAAPEVPEAlleqLAPGGRLVA--------PVGEGGVQRL 171
PRK11207 PRK11207
tellurite resistance methyltransferase TehB;
46-116 2.81e-03

tellurite resistance methyltransferase TehB;


Pssm-ID: 183040  Cd Length: 197  Bit Score: 37.79  E-value: 2.81e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446133877  46 ASVLDMGCGAGHASFVAAQNVSAVVAYDLSAQMLDVVAQAAEARQLKNITTRQGYAESLPFaDNAFDIVIS 116
Cdd:PRK11207  32 GKTLDLGCGNGRNSLYLAANGFDVTAWDKNPMSIANLERIKAAENLDNLHTAVVDLNNLTF-DGEYDFILS 101
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 44-150 2.98e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 38.40  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   44 PDASVLDMGCGAGHASFVAAQ-NVSAVVAYDLSAQMLDVvaqAAEARQLKNITTR-QGYA-ESLPfaDNAFDIVISRYSA 120
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKlGAKKVVGVDIDPVAVRA---AKENAELNGVEARlEVYLpGDLP--KEKADVVVANILA 235

                          90       100       110
                  ....*....|....*....|....*....|....
gi 446133877  121 HhwhdvgaALRE----VNRVLKPGGMLIVMDIMS 150
Cdd:pfam06325 236 D-------PLIElapdIYALVKPGGYLILSGILK 262
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
44-145 4.94e-03

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 36.96  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446133877   44 PDASVLDMGCGAGHASFVAAQNVSA---VVAYDLSAQMLDVVAQAAEARQLKNITT-----RQGYAESLPfadnafdivi 115
Cdd:pfam01135  73 PGMRVLEIGSGSGYLTACFARMVGEvgrVVSIEHIPELVEIARRNLEKLGLENVIVvvgdgRQGWPEFAP---------- 142

                          90       100       110
                  ....*....|....*....|....*....|....
gi 446133877  116 srYSAHHwhdVGAALREVNRV----LKPGGMLIV 145
Cdd:pfam01135 143 --YDAIH---VGAAAPEIPEAlidqLKEGGRLVI 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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