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Conserved domains on  [gi|446155465|ref|WP_000233320|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK09706 super family cl27794
transcriptional repressor DicA; Reviewed
30-137 3.64e-13

transcriptional repressor DicA; Reviewed


The actual alignment was detected with superfamily member PRK09706:

Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 62.18  E-value: 3.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446155465  30 QAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYLL--GEDTEESGQVRFYQ--ELNPRQKIIIDLLDELP 105
Cdd:PRK09706  21 QRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCSPTWLLfgDEDKQPTPPVPLNQpvELSEDQKELLELFDALP 100
                         90       100       110
                 ....*....|....*....|....*....|....
gi 446155465 106 DSETDELLKTLEEKKQKYNAIYEEL--ARKKKQK 137
Cdd:PRK09706 101 ESEQDAQLSEMRARVENFNKLFEELlkARKRSAK 134
 
Name Accession Description Interval E-value
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
30-137 3.64e-13

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 62.18  E-value: 3.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446155465  30 QAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYLL--GEDTEESGQVRFYQ--ELNPRQKIIIDLLDELP 105
Cdd:PRK09706  21 QRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCSPTWLLfgDEDKQPTPPVPLNQpvELSEDQKELLELFDALP 100
                         90       100       110
                 ....*....|....*....|....*....|....
gi 446155465 106 DSETDELLKTLEEKKQKYNAIYEEL--ARKKKQK 137
Cdd:PRK09706 101 ESEQDAQLSEMRARVENFNKLFEELlkARKRSAK 134
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
5-81 5.86e-09

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 49.61  E-value: 5.86e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446155465   5 DKARKEFASRLALACENAGYeqhgRQAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYLLGEDTEES 81
Cdd:COG1396    2 STLKKALGERLRELRKARGL----TQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEEL 74
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
12-73 5.19e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 44.08  E-value: 5.19e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446155465  12 ASRLALACENAGYeqhgRQAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYL 73
Cdd:cd00093    1 GERLKELRKEKGL----TQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
14-73 1.36e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 42.89  E-value: 1.36e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446155465    14 RLALACENAGYeqhgRQAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYL 73
Cdd:smart00530   1 RLKELREEKGL----TQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
30-73 1.44e-05

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 40.22  E-value: 1.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 446155465   30 QAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYL 73
Cdd:pfam01381  12 QEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
 
Name Accession Description Interval E-value
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
30-137 3.64e-13

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 62.18  E-value: 3.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446155465  30 QAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYLL--GEDTEESGQVRFYQ--ELNPRQKIIIDLLDELP 105
Cdd:PRK09706  21 QRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCSPTWLLfgDEDKQPTPPVPLNQpvELSEDQKELLELFDALP 100
                         90       100       110
                 ....*....|....*....|....*....|....
gi 446155465 106 DSETDELLKTLEEKKQKYNAIYEEL--ARKKKQK 137
Cdd:PRK09706 101 ESEQDAQLSEMRARVENFNKLFEELlkARKRSAK 134
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
5-81 5.86e-09

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 49.61  E-value: 5.86e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446155465   5 DKARKEFASRLALACENAGYeqhgRQAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYLLGEDTEES 81
Cdd:COG1396    2 STLKKALGERLRELRKARGL----TQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEEL 74
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
11-111 9.33e-09

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 52.43  E-value: 9.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446155465  11 FASRLALACENAGYEQHG-RQAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYLLGED--TEESGQVRFY 87
Cdd:PRK13355   4 FAERLKQAMKARGLKQEDlVHAAEARGVKLGKSHISQYVSGKTGPRRDVLPFLAAILGVSEDWLLGGEspADQESDASAV 83
                         90       100
                 ....*....|....*....|....
gi 446155465  88 QELNPRQKIIIDLLDELPDSETDE 111
Cdd:PRK13355  84 VESAPNSHLADPSAPTTPISQTSS 107
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
12-73 5.19e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 44.08  E-value: 5.19e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446155465  12 ASRLALACENAGYeqhgRQAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYL 73
Cdd:cd00093    1 GERLKELRKEKGL----TQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
14-73 1.36e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 42.89  E-value: 1.36e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446155465    14 RLALACENAGYeqhgRQAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYL 73
Cdd:smart00530   1 RLKELREEKGL----TQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
30-73 1.44e-05

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 40.22  E-value: 1.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 446155465   30 QAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYL 73
Cdd:pfam01381  12 QEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
8-77 5.07e-05

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 39.06  E-value: 5.07e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446155465   8 RKEFASRLALACENAGYeqhgRQAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTYLLGED 77
Cdd:COG1476    2 KKKLGNRLKELRKERGL----TQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFSLE 67
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
10-72 2.01e-04

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 37.61  E-value: 2.01e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446155465  10 EFASRLALACENAGYEQhgrqAEIARRMKLTPKAVSKWFNGETIPRREKLRELATLIGTTPTY 72
Cdd:COG1813   12 DYGERIREAREARGLSQ----EELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISLAE 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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