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Conserved domains on  [gi|446158145|ref|WP_000236000|]
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MULTISPECIES: acetate/propionate family kinase [Gammaproteobacteria]

Protein Classification

acetate/propionate family kinase( domain architecture ID 10000961)

acetate/propionate family kinase such as acetate kinase that catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
5-388 0e+00

Acetate kinase [Energy production and conversion];


:

Pssm-ID: 440051  Cd Length: 395  Bit Score: 581.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   5 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 77
Cdd:COG0282    3 ILVLNAGSSSLKFQLFDMDSEEVLAkGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIikdlde 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  78 -QAIGHRVVHGGS-LTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 155
Cdd:COG0282   83 iDAVGHRVVHGGEkFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 156 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 234
Cdd:COG0282  163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGKpLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 235 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 314
Cdd:COG0282  243 IDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446158145 315 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNnlKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQVVE 388
Cdd:COG0282  323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA--ARGGERVISTPDSRvKVLVIPTNEELMIARDTLRLLK 395
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
5-388 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 581.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   5 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 77
Cdd:COG0282    3 ILVLNAGSSSLKFQLFDMDSEEVLAkGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIikdlde 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  78 -QAIGHRVVHGGS-LTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 155
Cdd:COG0282   83 iDAVGHRVVHGGEkFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 156 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 234
Cdd:COG0282  163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGKpLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 235 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 314
Cdd:COG0282  243 IDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446158145 315 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNnlKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQVVE 388
Cdd:COG0282  323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA--ARGGERVISTPDSRvKVLVIPTNEELMIARDTLRLLK 395
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 5-388 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 567.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   5 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 77
Cdd:PRK00180   3 ILVLNAGSSSLKFQLIDMPNEEVLAsGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLglikdl 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  78 ---QAIGHRVVHGGSL-TKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRY 153
Cdd:PRK00180  83 deiTAVGHRVVHGGEKfTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYLY 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 154 AIPKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRS 232
Cdd:PRK00180 163 ALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKpLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTRS 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 233 GDVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGL-P 311
Cdd:PRK00180 243 GDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAALnG 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446158145 312 SIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNLKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQVVE 388
Cdd:PRK00180 323 RLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDISTPDSKvKVLVIPTNEELMIARDTLRLLG 400
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 5-386 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 523.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   5 VLVINCGSSSIKYALVSERREDR-IYGLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 77
Cdd:cd24010    1 ILVINCGSSSLKFQLFDMPTEEVlASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELgvslde 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  78 -QAIGHRVVHGG-SLTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 155
Cdd:cd24010   81 iDAVGHRVVHGGeKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 156 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 234
Cdd:cd24010  161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKpLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 235 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 314
Cdd:cd24010  241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446158145 315 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNlKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQV 386
Cdd:cd24010  321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKA-AGGGEREISTPDSKvKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 5-381 7.25e-152

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 434.54  E-value: 7.25e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145    5 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 77
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFDAVIGEVLLsGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIiellae 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   78 -QAIGHRVVHGGSL-TKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 155
Cdd:pfam00871  82 iTLIGHRVVHGGEKfTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  156 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGKFQKG-GWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 234
Cdd:pfam00871 162 PYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDlNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  235 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 314
Cdd:pfam00871 242 IDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLERLD 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446158145  315 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNnlKRGTEGRIDS-GTGPQIWVIPTDEEGRIAK 381
Cdd:pfam00871 322 AIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNN--RFGKSGVISTeDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 5-383 1.25e-151

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 434.54  E-value: 1.25e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145    5 VLVINCGSSSIKYALVSERREDRIY--GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP----- 77
Cdd:TIGR00016   6 ILVLNAGSSSLKFALFDAVNGEEVLasGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIiklls 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   78 --QAIGHRVVHGGS-LTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFP--ELPQVAVFDTAFHQTMPAHAYR 152
Cdd:TIGR00016  86 eiDLIGHRVVHGGEkFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLFPlpKAKNVAVFDTAFHQTMPEEAYL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  153 YAIPKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGKFQKG-GWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTR 231
Cdd:TIGR00016 166 YALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDlNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMMGTR 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  232 SGDVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLP 311
Cdd:TIGR00016 246 SGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYIASLE 325

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446158145  312 -SIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNLKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKET 383
Cdd:TIGR00016 326 gNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARSGKSGVISTPESKvKILVIPTNEELMIAQDA 399
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
5-388 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 581.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   5 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 77
Cdd:COG0282    3 ILVLNAGSSSLKFQLFDMDSEEVLAkGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIikdlde 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  78 -QAIGHRVVHGGS-LTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 155
Cdd:COG0282   83 iDAVGHRVVHGGEkFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 156 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 234
Cdd:COG0282  163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGKpLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 235 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 314
Cdd:COG0282  243 IDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446158145 315 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNnlKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQVVE 388
Cdd:COG0282  323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA--ARGGERVISTPDSRvKVLVIPTNEELMIARDTLRLLK 395
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 5-388 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 567.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   5 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 77
Cdd:PRK00180   3 ILVLNAGSSSLKFQLIDMPNEEVLAsGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLglikdl 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  78 ---QAIGHRVVHGGSL-TKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRY 153
Cdd:PRK00180  83 deiTAVGHRVVHGGEKfTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYLY 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 154 AIPKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRS 232
Cdd:PRK00180 163 ALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKpLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTRS 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 233 GDVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGL-P 311
Cdd:PRK00180 243 GDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAALnG 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446158145 312 SIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNLKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQVVE 388
Cdd:PRK00180 323 RLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDISTPDSKvKVLVIPTNEELMIARDTLRLLG 400
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 5-386 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 523.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   5 VLVINCGSSSIKYALVSERREDR-IYGLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 77
Cdd:cd24010    1 ILVINCGSSSLKFQLFDMPTEEVlASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELgvslde 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  78 -QAIGHRVVHGG-SLTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 155
Cdd:cd24010   81 iDAVGHRVVHGGeKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 156 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 234
Cdd:cd24010  161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKpLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 235 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 314
Cdd:cd24010  241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446158145 315 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNlKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQV 386
Cdd:cd24010  321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKA-AGGGEREISTPDSKvKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 5-381 7.25e-152

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 434.54  E-value: 7.25e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145    5 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 77
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFDAVIGEVLLsGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIiellae 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   78 -QAIGHRVVHGGSL-TKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 155
Cdd:pfam00871  82 iTLIGHRVVHGGEKfTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  156 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGKFQKG-GWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 234
Cdd:pfam00871 162 PYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDlNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  235 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 314
Cdd:pfam00871 242 IDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLERLD 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446158145  315 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNnlKRGTEGRIDS-GTGPQIWVIPTDEEGRIAK 381
Cdd:pfam00871 322 AIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNN--RFGKSGVISTeDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 5-383 1.25e-151

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 434.54  E-value: 1.25e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145    5 VLVINCGSSSIKYALVSERREDRIY--GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP----- 77
Cdd:TIGR00016   6 ILVLNAGSSSLKFALFDAVNGEEVLasGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIiklls 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   78 --QAIGHRVVHGGS-LTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFP--ELPQVAVFDTAFHQTMPAHAYR 152
Cdd:TIGR00016  86 eiDLIGHRVVHGGEkFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLFPlpKAKNVAVFDTAFHQTMPEEAYL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  153 YAIPKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGKFQKG-GWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTR 231
Cdd:TIGR00016 166 YALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDlNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMMGTR 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  232 SGDVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLP 311
Cdd:TIGR00016 246 SGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYIASLE 325

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446158145  312 -SIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNLKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKET 383
Cdd:TIGR00016 326 gNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARSGKSGVISTPESKvKILVIPTNEELMIAQDA 399
PRK12379 PRK12379
propionate kinase;
5-380 2.16e-145

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 418.37  E-value: 2.16e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   5 VLVINCGSSSIKYALVSERREDR-IYGLAENLGAADARIkgiTV-GGEPLELSipYADHAKALETLLARLA----NYKPQ 78
Cdd:PRK12379   7 VLVINCGSSSIKFSVLDASDCEVlMSGIADGINSENAFL---SVnGGEPAPLA--HHSYEGALKAIAFELEkrnlNDSVA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  79 AIGHRVVHGGSL-TKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAIPK 157
Cdd:PRK12379  82 LIGHRIAHGGSIfTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEAYLYGLPW 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 158 FLYTEHNVRRYGFHGTSHAYVSDRGSELAG-KFQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGDVD 236
Cdd:PRK12379 162 EYYEELGVRRYGFHGTSHRYVSQRAHSLLNlDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDVD 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 237 PSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSIDGL 316
Cdd:PRK12379 242 FGAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHAASLHRLDGI 321

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446158145 317 IFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNLKRGTEGRIDSGTGPQIW-VIPTDEEGRIA 380
Cdd:PRK12379 322 IFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQPNSGGERIISSENSRVICaVIPTNEEKMIA 386
PRK12440 PRK12440
acetate/propionate family kinase;
1-383 6.61e-124

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 363.80  E-value: 6.61e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   1 MATS-VLVINCGSSSIKYALV-SERREDRIYGLAENLGAADARIkGITVGGEPLELSIPYAD--HAKALETLLARLANY- 75
Cdd:PRK12440   1 MSNSyVLVINSGSSSLKFAVIdSVTGEAVLSGLGECFGLEDARM-SWKYQGEKTEIAIEGEDnhHKIAIGRLVGLTEELg 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  76 ---KPQAIGHRVVHGG-SLTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAY 151
Cdd:PRK12440  80 ftqDIVAVGHRIVHGGeKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 152 RYAIPKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGT 230
Cdd:PRK12440 160 TGAIAKELYTDFGIRRYGFHGTSHYFVSREAAKMLNKpIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 231 RSGDVDPSLHSFLAKNlGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGL 310
Cdd:PRK12440 240 RCGDLDPGIIEFLLKK-GWSQEKVFNSLNKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYLAAL 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446158145 311 PSIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNLKRGTEGRIDSGT--GPQIWVIPTDEEGRIAKET 383
Cdd:PRK12440 319 DSLDGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDARFGKAGIIAKSEllNAVAMVIPTNEEFVIAQQS 393
PRK07157 PRK07157
acetate kinase; Provisional
 1-388 3.35e-115

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 341.72  E-value: 3.35e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   1 MATSVLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKgITVGGEPLELSIPYADHAKALETLLARLANYKP-- 77
Cdd:PRK07157   1 MKAKILVINAGSSSIKWQLFDKENLNLIAsGLAERIGLENGLIK-IKFGKKKYEKEVDMPNHKVAVAVLIEIWEENKLie 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  78 -----QAIGHRVVHGG-SLTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAY 151
Cdd:PRK07157  80 dleeiELIGFRVVHGGdYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 152 RYAIPKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGKfQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTR 231
Cdd:PRK07157 160 TYPINYEIAKKYGIKKYGFHGISHKFITNKVEKILNK-DKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGTR 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 232 SGDVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGL- 310
Cdd:PRK07157 239 SGDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDYLANYINKIg 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 311 PSIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNlKRGTEGRIDSGTGPQ----IWVIPTDEEGRIAKETRQV 386
Cdd:PRK07157 319 KKIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLK-KIGEYGPIELISTPDsdipVYVIRTNEELLIAKNAIKL 397


                 ..
gi 446158145 387 VE 388
Cdd:PRK07157 398 YE 399
PRK12397 PRK12397
acetate/propionate family kinase;
1-400 5.50e-115

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 341.43  E-value: 5.50e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   1 MATSVLVINCGSSSIKYALVSERREDRI-YGLAENLGAADARIKgITVGGEPLELSIPYADHAKALETLLARLANYKP-- 77
Cdd:PRK12397   1 MSYKIMAINAGSSSLKFQLLEMPQGDMLcQGLIERIGMADAQVT-IKTHSQKWQETVPVADHRDAVTLLLEKLLGYQIin 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  78 -----QAIGHRVVHGGSLTK-AELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAY 151
Cdd:PRK12397  80 slrdiDGVGHRVAHGGEFFKdSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 152 RYAIPKFLYTEHNVRRYGFHGTSHAYVSdrgSELAGKFqkGGWLTA------HLGNGSSTCAVWNGQSVDTSMGLTPLEG 225
Cdd:PRK12397 160 IYPLPWRYYAELGIRRYGFHGTSHKYVS---GVLAEKL--GVPLSAlrviccHLGNGSSICAIKNGRSVNTSMGFTPQSG 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 226 VVMGTRSGDVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAA 305
Cdd:PRK12397 235 VMMGTRSGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGS 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 306 LSCGLPSIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNlkrgTEGRIDSGTGP-QIWVIPTDEEGRIAketR 384
Cdd:PRK12397 315 YIMQMGGLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQR----NATFIQTENALvKVAVINTNEELMIA---Q 387

                        410
                 ....*....|....*.
gi 446158145 385 QVVEVSQNTSPEVSLA 400
Cdd:PRK12397 388 DVMRIALPATEGLCVP 403
PRK07058 PRK07058
acetate/propionate family kinase;
1-383 1.75e-86

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 268.07  E-value: 1.75e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145   1 MATSVLV-INCGSSSIKYAL--VSERREDRIYGLAENLGAADARIkGITVGGEPLELSI---PYADHAKALETLLARLAN 74
Cdd:PRK07058   1 MSKPLLLtFNAGSSTVKIGLfeVDGNEARRIGKGDIDFRRAPLRF-HLRNGGETLDIPLkasVTDDLHTVLDETFDWLAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145  75 YKPQ----AIGHRVVHGG-SLTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAH 149
Cdd:PRK07058  80 HFDVselvAVGHRVVHGGdRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRTQPDL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 150 AYRYAIPKFLYtEHNVRRYGFHGTSHAYVSDRGSELAGKFQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMG 229
Cdd:PRK07058 160 VRRFAIPRALH-DEGIKRYGFHGLSYKFVAGELRRRAPELARGKVVAAHLGSGASLCALDAGKSRDTSMGFSTLDGIPMA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 230 TRSGDVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIeaaENGNEDACLAIEVFSYRLAKSLAALSCG 309
Cdd:PRK07058 239 TRCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDLL---ASDAPEAREALDLFALRIAGEIARLAAT 315

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446158145 310 LPSIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNlkrgTEGRIDSGTGP-QIWVIPTDEEGRIAKET 383
Cdd:PRK07058 316 LGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAA----NAFTISSRTSRvAAFVIPTDEEQVIADEA 386
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 166-332 1.37e-14

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 74.11  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 166 RRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLtPLEGVVMGTRSGDVDPSLHSFLA 244
Cdd:cd24011  147 RRSIFHALNQKAVARRAAKELGKpYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGTLPVGDLIKLC 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 245 KNLGWDLAKIDKVLNNESGLLGLSQlSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLP-SIDGLIFTGGIG 323
Cdd:cd24011  226 FSGKYTLEELKKKLKGKGGLVAYLG-TNDFREVEKRIEAGDEKAKLVLDAMAYQIAKEIGALAAVLKgKVDAIILTGGLA 304


                 ....*....
gi 446158145 324 eNSAYIREK 332
Cdd:cd24011  305 -YSKRLVDR 312
PRK03011 PRK03011
butyrate kinase; Provisional
 166-322 3.49e-10

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 60.94  E-value: 3.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 166 RRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLtPLEGVVMGTRSGDVdPSLhsfla 244
Cdd:PRK03011 149 RKSIFHALNQKAVARRVAKELGKkYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGGL-PVG----- 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446158145 245 knlgwDLAK-----------IDKVLNNESGLLGLsqL-SNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLP- 311
Cdd:PRK03011 222 -----DLVElcfsgkytkeeLKKKLVGKGGLVAY--LgTNDAREVEKRIEEGDEKAKLVYEAMAYQIAKEIGAMAAVLKg 294

                        170
                 ....*....|.
gi 446158145 312 SIDGLIFTGGI 322
Cdd:PRK03011 295 KVDAIVLTGGL 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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