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Conserved domains on  [gi|446167790|ref|WP_000245645|]
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MULTISPECIES: mannose/fructose/sorbose PTS transporter subunit IIA [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTS_IIA_man super family cl00025
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 1-114 4.59e-45

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


The actual alignment was detected with superfamily member TIGR00824:

Pssm-ID: 444659  Cd Length: 116  Bit Score: 142.60  E-value: 4.59e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446167790    1 MVNAIFCAHGKLACAMLESVQMVYG-NANVEAVEFVPGENAGDIVAKLEKLVS-IHNQDEWLIAVDLQCGSPWNAAAMLA 78
Cdd:TIGR00824   1 MIAIIISGHGQAAIALLKSAEMIFGeQNNVGAVPFVPGENAETLQEKYNAALAdLDTEEEVLFLVDIFGGSPYNAAARII 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 446167790   79 MRNPRLRVISGLSLPLALELVDNQDSMNVDELCEHL 114
Cdd:TIGR00824  81 VDKPHMDVIAGVNLPLLLETLMARDDLSFDDLVALL 116
 
Name Accession Description Interval E-value
EIIA-man TIGR00824
PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters ...
 1-114 4.59e-45

PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIA components. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 129904  Cd Length: 116  Bit Score: 142.60  E-value: 4.59e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446167790    1 MVNAIFCAHGKLACAMLESVQMVYG-NANVEAVEFVPGENAGDIVAKLEKLVS-IHNQDEWLIAVDLQCGSPWNAAAMLA 78
Cdd:TIGR00824   1 MIAIIISGHGQAAIALLKSAEMIFGeQNNVGAVPFVPGENAETLQEKYNAALAdLDTEEEVLFLVDIFGGSPYNAAARII 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 446167790   79 MRNPRLRVISGLSLPLALELVDNQDSMNVDELCEHL 114
Cdd:TIGR00824  81 VDKPHMDVIAGVNLPLLLETLMARDDLSFDDLVALL 116
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 5-127 6.73e-38

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 124.87  E-value: 6.73e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446167790   5 IFCAHGKLACAMLESVQMVYGN-ANVEAVEFVPGENAGDIVAKLEKLV-SIHNQDEWLIAVDLQCGSPWNAAAMLAMRNP 82
Cdd:COG2893    2 VIATHGPLAEGLLSSAEMILGEqENVEAVDLYPGDDPEDLREKLEEAIaELDSGDGVLILTDLFGGTPSNVAARLLAKHE 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 446167790  83 RLRVISGLSLPLALELVDNQDSMNVDELCEHLTQIAKQTCVVWKQ 127
Cdd:COG2893   82 NVEVIAGVNLPMLLEALTYREDLSLDELVEKALEAGREGIKSLSE 126
PTS_IIA_man cd00006
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 2-120 3.51e-33

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


Pssm-ID: 237978 [Multi-domain]  Cd Length: 122  Bit Score: 112.70  E-value: 3.51e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446167790   2 VNAIFCAHGKLACAMLESVQMVYG-NANVEAVEFVPGENAGDIVAKLEKLVS-IHNQDEWLIAVDLQCGSPWNAAAMLAM 79
Cdd:cd00006    1 VGIIIATHGGFASGLLNSAEMILGeQENVEAIDFPPGESPDDLLEKIKAALAeLDSGEGVLILTDLFGGSPNNAAARLSM 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446167790  80 RNPRLRVISGLSLPLALELVDNQDS-MNVDELCEHLTQIAKQ 120
Cdd:cd00006   81 EHPPVEVIAGVNLPMLLEAARARELgLSLDELVENALEAGRE 122
EIIA-man pfam03610
PTS system fructose IIA component;
9-113 1.67e-14

PTS system fructose IIA component;


Pssm-ID: 427399 [Multi-domain]  Cd Length: 113  Bit Score: 64.58  E-value: 1.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446167790    9 HGKLACAMLESVQMVYG-NANVEAVEFVPGENAGDIVAKL-EKLVSIHNQDEWLIAVDLQCGSPWNAAAMLAMRNPRLRV 86
Cdd:pfam03610   7 HGELAEGLLELAEMMAGeQENVIAVGGTPGESIGTSFEKIvEAIENLDSGDGVLVLVDLGGATPNNEAALELLEKERMEV 86

                          90       100
                  ....*....|....*....|....*..
gi 446167790   87 ISGLSLPLALELVDNQDSMNVDELCEH 113
Cdd:pfam03610  87 ITGVNLPMVEGAYAARVSASLGELVEA 113
PRK15088 PRK15088
PTS system mannose-specific transporter subunits IIAB; Provisional
 5-110 6.75e-14

PTS system mannose-specific transporter subunits IIAB; Provisional


Pssm-ID: 185045 [Multi-domain]  Cd Length: 322  Bit Score: 66.56  E-value: 6.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446167790   5 IFCAHGKLACAMLESVQMVYG-NANVEAVEFVPGENAGDIVAKL-EKLVSIHNQDEWLIAVDLQCGSPWNAAAMLAMRNP 82
Cdd:PRK15088   6 IIGTHGWAAEQLLKTAEMLLGeQENVAWIDFVPGENAETLIEKYnAQLAKLDTSKGVLFLVDTWGGSPFNAASRIVVDKE 85

                         90       100
                 ....*....|....*....|....*....
gi 446167790  83 RLRVISGLSLPLALE-LVDNQDSMNVDEL 110
Cdd:PRK15088  86 NYEVITGVNIPMLVEtFMARDDDPSFDEL 114
 
Name Accession Description Interval E-value
EIIA-man TIGR00824
PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters ...
 1-114 4.59e-45

PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIA components. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 129904  Cd Length: 116  Bit Score: 142.60  E-value: 4.59e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446167790    1 MVNAIFCAHGKLACAMLESVQMVYG-NANVEAVEFVPGENAGDIVAKLEKLVS-IHNQDEWLIAVDLQCGSPWNAAAMLA 78
Cdd:TIGR00824   1 MIAIIISGHGQAAIALLKSAEMIFGeQNNVGAVPFVPGENAETLQEKYNAALAdLDTEEEVLFLVDIFGGSPYNAAARII 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 446167790   79 MRNPRLRVISGLSLPLALELVDNQDSMNVDELCEHL 114
Cdd:TIGR00824  81 VDKPHMDVIAGVNLPLLLETLMARDDLSFDDLVALL 116
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 5-127 6.73e-38

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 124.87  E-value: 6.73e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446167790   5 IFCAHGKLACAMLESVQMVYGN-ANVEAVEFVPGENAGDIVAKLEKLV-SIHNQDEWLIAVDLQCGSPWNAAAMLAMRNP 82
Cdd:COG2893    2 VIATHGPLAEGLLSSAEMILGEqENVEAVDLYPGDDPEDLREKLEEAIaELDSGDGVLILTDLFGGTPSNVAARLLAKHE 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 446167790  83 RLRVISGLSLPLALELVDNQDSMNVDELCEHLTQIAKQTCVVWKQ 127
Cdd:COG2893   82 NVEVIAGVNLPMLLEALTYREDLSLDELVEKALEAGREGIKSLSE 126
PTS_IIA_man cd00006
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 2-120 3.51e-33

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


Pssm-ID: 237978 [Multi-domain]  Cd Length: 122  Bit Score: 112.70  E-value: 3.51e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446167790   2 VNAIFCAHGKLACAMLESVQMVYG-NANVEAVEFVPGENAGDIVAKLEKLVS-IHNQDEWLIAVDLQCGSPWNAAAMLAM 79
Cdd:cd00006    1 VGIIIATHGGFASGLLNSAEMILGeQENVEAIDFPPGESPDDLLEKIKAALAeLDSGEGVLILTDLFGGSPNNAAARLSM 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446167790  80 RNPRLRVISGLSLPLALELVDNQDS-MNVDELCEHLTQIAKQ 120
Cdd:cd00006   81 EHPPVEVIAGVNLPMLLEAARARELgLSLDELVENALEAGRE 122
EIIA-man pfam03610
PTS system fructose IIA component;
9-113 1.67e-14

PTS system fructose IIA component;


Pssm-ID: 427399 [Multi-domain]  Cd Length: 113  Bit Score: 64.58  E-value: 1.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446167790    9 HGKLACAMLESVQMVYG-NANVEAVEFVPGENAGDIVAKL-EKLVSIHNQDEWLIAVDLQCGSPWNAAAMLAMRNPRLRV 86
Cdd:pfam03610   7 HGELAEGLLELAEMMAGeQENVIAVGGTPGESIGTSFEKIvEAIENLDSGDGVLVLVDLGGATPNNEAALELLEKERMEV 86

                          90       100
                  ....*....|....*....|....*..
gi 446167790   87 ISGLSLPLALELVDNQDSMNVDELCEH 113
Cdd:pfam03610  87 ITGVNLPMVEGAYAARVSASLGELVEA 113
PRK15088 PRK15088
PTS system mannose-specific transporter subunits IIAB; Provisional
 5-110 6.75e-14

PTS system mannose-specific transporter subunits IIAB; Provisional


Pssm-ID: 185045 [Multi-domain]  Cd Length: 322  Bit Score: 66.56  E-value: 6.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446167790   5 IFCAHGKLACAMLESVQMVYG-NANVEAVEFVPGENAGDIVAKL-EKLVSIHNQDEWLIAVDLQCGSPWNAAAMLAMRNP 82
Cdd:PRK15088   6 IIGTHGWAAEQLLKTAEMLLGeQENVAWIDFVPGENAETLIEKYnAQLAKLDTSKGVLFLVDTWGGSPFNAASRIVVDKE 85

                         90       100
                 ....*....|....*....|....*....
gi 446167790  83 RLRVISGLSLPLALE-LVDNQDSMNVDEL 110
Cdd:PRK15088  86 NYEVITGVNIPMLVEtFMARDDDPSFDEL 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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