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Conserved domains on  [gi|446168906|ref|WP_000246761|]
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MULTISPECIES: malonyl-ACP O-methyltransferase BioC [Gammaproteobacteria]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 11484635)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 1-251 7.05e-170

biotin biosynthesis protein BioC; Provisional


:

Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 468.47  E-value: 7.05e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   1 MATVNKQAIAAAFGRAAAHYEQHADLQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQA 80
Cdd:PRK10258   1 MATVNKQAIAAAFGRAAAHYEQHAELQRQSADALLAMLPQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  81 RQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPKGVVAFTTLVQGSLPELHQAWQAVDERP 160
Cdd:PRK10258  81 RQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906 161 HANRFLPPDEIEQSLNGVHYQHHIQPITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQRLQLAWPQQQGRYPLT 240
Cdd:PRK10258 161 HANRFLPPDAIEQALNGWRYQHHIQPITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQRLQLAWPQQQGRYPLT 240

                        250
                 ....*....|.
gi 446168906 241 YHLFLGVIARE 251
Cdd:PRK10258 241 YHLFLGVIERD 251
 
Name Accession Description Interval E-value
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 1-251 7.05e-170

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 468.47  E-value: 7.05e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   1 MATVNKQAIAAAFGRAAAHYEQHADLQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQA 80
Cdd:PRK10258   1 MATVNKQAIAAAFGRAAAHYEQHAELQRQSADALLAMLPQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  81 RQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPKGVVAFTTLVQGSLPELHQAWQAVDERP 160
Cdd:PRK10258  81 RQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906 161 HANRFLPPDEIEQSLNGVHYQHHIQPITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQRLQLAWPQQQGRYPLT 240
Cdd:PRK10258 161 HANRFLPPDAIEQALNGWRYQHHIQPITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQRLQLAWPQQQGRYPLT 240

                        250
                 ....*....|.
gi 446168906 241 YHLFLGVIARE 251
Cdd:PRK10258 241 YHLFLGVIERD 251
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 19-250 2.42e-90

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 266.85  E-value: 2.42e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   19 HYEQHADLQRQSADALLAMLPQR---KYTHVLDAGCGPGWMSRHWRERHAQV--TALDLSPPMLVQARQKDAA-DHYLAG 92
Cdd:TIGR02072   8 TYDRHAKIQREMAKRLLALLKEKgifIPASVLDIGCGTGYLTRALLKRFPQAefIALDISAGMLAQAKTKLSEnVQFICG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   93 DIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPKGVVAFTTLVQGSLPELHQAWQAvderpHANRFLPPDEIE 172
Cdd:TIGR02072  88 DAEKLPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQSFGQ-----HGLRYLSLDELK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  173 QSLNGV--HYQHHIQPITLWFDDALSAMRSLKGIGATHLHEGRdpriLTRSQLQRLQLAWPQ--QQGRYPLTYHLFLGVI 248
Cdd:TIGR02072 163 ALLKNSfeLLTLEEELITLSFDDPLDVLRHLKKTGANGLSSGR----TSRKQLKAFLERYEQefQPDGLPLTYHVVYGIA 238


                  ..
gi 446168906  249 AR 250
Cdd:TIGR02072 239 KK 240
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 20-156 1.08e-35

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 123.95  E-value: 1.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  20 YEQHADlQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQARQKDAAD----HYLAGDIE 95
Cdd:COG2226    1 FDRVAA-RYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAglnvEFVVGDAE 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446168906  96 SLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPKGVVAFTTLVQGSLPELHQAWQAV 156
Cdd:COG2226   80 DLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEA 140
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 47-138 9.40e-30

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 106.98  E-value: 9.40e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   47 LDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQARQKDAAD--HYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALR 124
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREglTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALR 80

                          90
                  ....*....|....
gi 446168906  125 ELYRVVRPKGVVAF 138
Cdd:pfam08241  81 EIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 46-142 2.16e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 69.77  E-value: 2.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  46 VLDAGCGPGWMSRHWRERH-AQVTALDLSPPMLVQARQKDAAD-----HYLAGDIESLPLAT-ATFDLAWSNLAVQW-CG 117
Cdd:cd02440    2 VLDLGCGTGALALALASGPgARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPEAdESFDVIISDPPLHHlVE 81

                         90       100
                 ....*....|....*....|....*
gi 446168906 118 NLSTALRELYRVVRPKGVVAFTTLV 142
Cdd:cd02440   82 DLARFLEEARRLLKPGGVLVLTLVL 106
 
Name Accession Description Interval E-value
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 1-251 7.05e-170

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 468.47  E-value: 7.05e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   1 MATVNKQAIAAAFGRAAAHYEQHADLQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQA 80
Cdd:PRK10258   1 MATVNKQAIAAAFGRAAAHYEQHAELQRQSADALLAMLPQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  81 RQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPKGVVAFTTLVQGSLPELHQAWQAVDERP 160
Cdd:PRK10258  81 RQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906 161 HANRFLPPDEIEQSLNGVHYQHHIQPITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQRLQLAWPQQQGRYPLT 240
Cdd:PRK10258 161 HANRFLPPDAIEQALNGWRYQHHIQPITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQRLQLAWPQQQGRYPLT 240

                        250
                 ....*....|.
gi 446168906 241 YHLFLGVIARE 251
Cdd:PRK10258 241 YHLFLGVIERD 251
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 19-250 2.42e-90

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 266.85  E-value: 2.42e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   19 HYEQHADLQRQSADALLAMLPQR---KYTHVLDAGCGPGWMSRHWRERHAQV--TALDLSPPMLVQARQKDAA-DHYLAG 92
Cdd:TIGR02072   8 TYDRHAKIQREMAKRLLALLKEKgifIPASVLDIGCGTGYLTRALLKRFPQAefIALDISAGMLAQAKTKLSEnVQFICG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   93 DIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPKGVVAFTTLVQGSLPELHQAWQAvderpHANRFLPPDEIE 172
Cdd:TIGR02072  88 DAEKLPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQSFGQ-----HGLRYLSLDELK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  173 QSLNGV--HYQHHIQPITLWFDDALSAMRSLKGIGATHLHEGRdpriLTRSQLQRLQLAWPQ--QQGRYPLTYHLFLGVI 248
Cdd:TIGR02072 163 ALLKNSfeLLTLEEELITLSFDDPLDVLRHLKKTGANGLSSGR----TSRKQLKAFLERYEQefQPDGLPLTYHVVYGIA 238


                  ..
gi 446168906  249 AR 250
Cdd:TIGR02072 239 KK 240
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 20-156 1.08e-35

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 123.95  E-value: 1.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  20 YEQHADlQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQARQKDAAD----HYLAGDIE 95
Cdd:COG2226    1 FDRVAA-RYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAglnvEFVVGDAE 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446168906  96 SLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPKGVVAFTTLVQGSLPELHQAWQAV 156
Cdd:COG2226   80 DLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEA 140
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 47-138 9.40e-30

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 106.98  E-value: 9.40e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   47 LDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQARQKDAAD--HYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALR 124
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREglTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALR 80

                          90
                  ....*....|....
gi 446168906  125 ELYRVVRPKGVVAF 138
Cdd:pfam08241  81 EIARVLKPGGILII 94
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
19-140 4.86e-29

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 107.78  E-value: 4.86e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  19 HYEQHADLqrqsADALLAMLPQRKYTHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQARQKDAADHYLAGDIESLP 98
Cdd:COG4976   27 GYEAPALL----AEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYDRLLVADLADLA 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446168906  99 LATATFDLAWSNLAVQWCGNLSTALRELYRVVRPKGVVAFTT 140
Cdd:COG4976  103 EPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSV 144
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 46-134 1.20e-26

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 99.18  E-value: 1.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   46 VLDAGCGPGWMSRHWRERH-AQVTALDLSPPMLVQARQKDAAD----HYLAGDIESLPLATATFDLAWSNLAVQWCG--N 118
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGgARVTGVDLSPEMLERARERAAEAglnvEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPdpD 80

                          90
                  ....*....|....*.
gi 446168906  119 LSTALRELYRVVRPKG 134
Cdd:pfam13649  81 LEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 45-140 1.32e-24

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 94.70  E-value: 1.32e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  45 HVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQARQKDAAD--HYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTA 122
Cdd:COG2227   27 RVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELnvDFVQGDLEDLPLEDGSFDLVICSEVLEHLPDPAAL 106

                         90
                 ....*....|....*...
gi 446168906 123 LRELYRVVRPKGVVAFTT 140
Cdd:COG2227  107 LRELARLLKPGGLLLLST 124
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
45-140 2.01e-24

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 93.35  E-value: 2.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  45 HVLDAGCGPGWMSRHWRER--HAQVTALDLSPPMLVQARQKDAADHYLAGDIESLPLAtATFDLAWSNLAVQWCGNLSTA 122
Cdd:COG4106    4 RVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLPNVRFVVADLRDLDPP-EPFDLVVSNAALHWLPDHAAL 82

                         90
                 ....*....|....*...
gi 446168906 123 LRELYRVVRPKGVVAFTT 140
Cdd:COG4106   83 LARLAAALAPGGVLAVQV 100
PRK08317 PRK08317
hypothetical protein; Provisional
 25-140 1.22e-15

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 73.82  E-value: 1.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  25 DLQRQSADALLAMLPQRKYThVLDAGCGPGWMSRHWRER---HAQVTALDLSPPMLVQARQKDAADH----YLAGDIESL 97
Cdd:PRK08317   3 DFRRYRARTFELLAVQPGDR-VLDVGCGPGNDARELARRvgpEGRVVGIDRSEAMLALAKERAAGLGpnveFVRGDADGL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446168906  98 PLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPKG-VVAFTT 140
Cdd:PRK08317  82 PFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGrVVVLDT 125
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 24-140 1.42e-15

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 71.88  E-value: 1.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  24 ADLQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRHW-RERHAQVTALDLSPPMLVQARQKDAAD------HYLAGDIES 96
Cdd:COG2230   33 EEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLaRRYGVRVTGVTLSPEQLEYARERAAEAgladrvEVRLADYRD 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446168906  97 LPlATATFDLAWSNLAVQWCG--NLSTALRELYRVVRPKGVVAFTT 140
Cdd:COG2230  113 LP-ADGQFDAIVSIGMFEHVGpeNYPAYFAKVARLLKPGGRLLLHT 157
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 46-142 2.16e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 69.77  E-value: 2.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  46 VLDAGCGPGWMSRHWRERH-AQVTALDLSPPMLVQARQKDAAD-----HYLAGDIESLPLAT-ATFDLAWSNLAVQW-CG 117
Cdd:cd02440    2 VLDLGCGTGALALALASGPgARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPEAdESFDVIISDPPLHHlVE 81

                         90       100
                 ....*....|....*....|....*
gi 446168906 118 NLSTALRELYRVVRPKGVVAFTTLV 142
Cdd:cd02440   82 DLARFLEEARRLLKPGGVLVLTLVL 106
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 41-168 2.39e-15

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 72.88  E-value: 2.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  41 RKYTHVLDAGCGPGWMSRHWRERH---AQVTALDLSPPMLVQARQKDAAD------HYLAGDIESLPLATATFDLAwS-- 109
Cdd:PRK00216  50 RPGDKVLDLACGTGDLAIALAKAVgktGEVVGLDFSEGMLAVGREKLRDLglsgnvEFVQGDAEALPFPDNSFDAV-Tia 128

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446168906 110 ----NLAvqwcgNLSTALRELYRVVRPKGVVA---FTTLVQGSLPELHQAWqavderphANRFLPP 168
Cdd:PRK00216 129 fglrNVP-----DIDKALREMYRVLKPGGRLVileFSKPTNPPLKKAYDFY--------LFKVLPL 181
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 23-139 2.77e-14

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 69.17  E-value: 2.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  23 HADLQRQSADALLAMLPQ-RKYTHVLDAGCGPGWMSRHWRER-HAQVTALDLSPPMLVQARQKDAAD-----HYLAGDI- 94
Cdd:COG0500    6 YSDELLPGLAALLALLERlPKGGRVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALARARAAKAglgnvEFLVADLa 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446168906  95 ESLPLATATFDLAWSNLAVQWC--GNLSTALRELYRVVRPKGVVAFT 139
Cdd:COG0500   86 ELDPLPAESFDLVVAFGVLHHLppEEREALLRELARALKPGGVLLLS 132
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 44-142 1.03e-11

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 61.28  E-value: 1.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   44 THVLDAGCGPGWMSRHWRER---HAQVTALDLSPPMLVQARQKdAADHYL------AGDIESLP--LATATFDLAWSNLA 112
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELAEElgpNAEVVGIDISEEAIEKAREN-AQKLGFdnvefeQGDIEELPelLEDDKFDVVISNCV 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 446168906  113 VQWCGNLSTALRELYRVVRPKGVVAFTTLV 142
Cdd:pfam13847  84 LNHIPDPDKVLQEILRVLKPGGRLIISDPD 113
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 47-136 2.28e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 58.92  E-value: 2.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   47 LDAGCGPGWMSRHWRE--RHAQVTALDLSPPMLVQARQKDAAD--------HYLAGDIESLPLATatFDLAWSNLAVQWC 116
Cdd:pfam08242   1 LEIGCGTGTLLRALLEalPGLEYTGLDISPAALEAARERLAALgllnavrvELFQLDLGELDPGS--FDVVVASNVLHHL 78

                          90       100
                  ....*....|....*....|
gi 446168906  117 GNLSTALRELYRVVRPKGVV 136
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPGGVL 98
PRK05785 PRK05785
hypothetical protein; Provisional
 46-137 5.50e-10

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 57.78  E-value: 5.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  46 VLDAGCGPGWMSRHWR-ERHAQVTALDLSPPMLvqaRQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALR 124
Cdd:PRK05785  55 VLDVAAGKGELSYHFKkVFKYYVVALDYAENML---KMNLVADDKVVGSFEALPFRDKSFDVVMSSFALHASDNIEKVIA 131

                         90
                 ....*....|....
gi 446168906 125 ELYRVVRPK-GVVA 137
Cdd:PRK05785 132 EFTRVSRKQvGFIA 145
arsM PRK11873
arsenite methyltransferase;
46-148 4.50e-09

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 55.34  E-value: 4.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  46 VLDAGCGPG---WMSRHWRERHAQVTALDLSPPMLVQARQKDAADHY-----LAGDIESLPLATATFDLAWSNLAVqwcg 117
Cdd:PRK11873  81 VLDLGSGGGfdcFLAARRVGPTGKVIGVDMTPEMLAKARANARKAGYtnvefRLGEIEALPVADNSVDVIISNCVI---- 156

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446168906 118 NLS----TALRELYRVVRPKGVVAFTTLVQ-GSLPE 148
Cdd:PRK11873 157 NLSpdkeRVFKEAFRVLKPGGRFAISDVVLrGELPE 192
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 28-137 1.09e-08

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 54.18  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  28 RQSADaLLAMLPQRKYTHVLDAGCGPGWMSRHWRERH--AQVTALDLSPPMLVQARQKDAADHYLAGDIESLPLATATfD 105
Cdd:PRK01683  18 RPARD-LLARVPLENPRYVVDLGCGPGNSTELLVERWpaARITGIDSSPAMLAEARSRLPDCQFVEADIASWQPPQAL-D 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446168906 106 LAWSNLAVQWCGNLSTALRELYRVVRPKGVVA 137
Cdd:PRK01683  96 LIFANASLQWLPDHLELFPRLVSLLAPGGVLA 127
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 20-115 4.85e-08

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 52.38  E-value: 4.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  20 YEQHADLQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRHWRER--HAQVTALDLSPPMLVQARQK--DAAdhylAGDIE 95
Cdd:PRK14103   7 YLAFADHRGRPFYDLLARVGAERARRVVDLGCGPGNLTRYLARRwpGAVIEALDSSPEMVAAARERgvDAR----TGDVR 82

                         90       100
                 ....*....|....*....|
gi 446168906  96 SLpLATATFDLAWSNLAVQW 115
Cdd:PRK14103  83 DW-KPKPDTDVVVSNAALQW 101
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
29-136 1.14e-07

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 51.12  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  29 QSADALLAMLPQRKYtHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQARQkDAAD----------HYLAGDIESlP 98
Cdd:PRK11036  32 QDLDRLLAELPPRPL-RVLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQRAKQ-AAEAkgvsdnmqfiHCAAQDIAQ-H 108

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446168906  99 LATATfDLAWSNLAVQWCGNLSTALRELYRVVRPKGVV 136
Cdd:PRK11036 109 LETPV-DLILFHAVLEWVADPKSVLQTLWSVLRPGGAL 145
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 32-97 5.32e-07

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 49.07  E-value: 5.32e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446168906  32 DALLAMLPQR---KYTHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQARQKDAADH------YLAGDIESL 97
Cdd:PRK07580  50 DTVLSWLPADgdlTGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAGlagnitFEVGDLESL 124
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
46-155 5.36e-07

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 48.97  E-value: 5.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   46 VLDAGCGPG-W---MSRHWRERhAQVTALDLSPPMLVQARQKdAAD------HYLAGDIESLPLATATFDLAWSNLAVQW 115
Cdd:pfam01209  46 FLDVAGGTGdWtfgLSDSAGSS-GKVVGLDINENMLKEGEKK-AKEegkyniEFLQGNAEELPFEDDSFDIVTISFGLRN 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 446168906  116 CGNLSTALRELYRVVRPKGVVAFTTLVQGSLPELHQAWQA 155
Cdd:pfam01209 124 FPDYLKVLKEAFRVLKPGGRVVCLEFSKPENPLLSQAYEL 163
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 23-175 1.03e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 47.42  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906   23 HADLQRQSADALLAMLPQRKYT-HVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQARQKDAADHYlagDIESLPLAT 101
Cdd:pfam13489   2 AHQRERLLADLLLRLLPKLPSPgRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQF---DEQEAAVPA 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446168906  102 ATFDLAWSNLAVQWCGNLSTALRELYRVVRPKGVVAFTTLVQ--GSLPELHQAWQAVDERPHANrFLPPDEIEQSL 175
Cdd:pfam13489  79 GKFDVIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPLAsdEADRLLLEWPYLRPRNGHIS-LFSARSLKRLL 153
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 32-135 1.69e-06

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 48.35  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  32 DALL-AMLPQRKYThVLDAGCGPGWMS----RHWRERHaqVTALDLSPPMLVQARQKDAADH--YLAGDIESLPLATATF 104
Cdd:PLN02490 103 DALEpADLSDRNLK-VVDVGGGTGFTTlgivKHVDAKN--VTILDQSPHQLAKAKQKEPLKEckIIEGDAEDLPFPTDYA 179

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446168906 105 DLAWSNLAVQWCGNLSTALRELYRVVRPKGV 135
Cdd:PLN02490 180 DRYVSAGSIEYWPDPQRGIKEAYRVLKIGGK 210
PLN02244 PLN02244
tocopherol O-methyltransferase
 39-140 7.73e-05

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 43.19  E-value: 7.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  39 PQRKYTHVLDAGCGPGWMSRHW-RERHAQVTALDLSPpmlVQA-RQKD-AADHYLA-------GDIESLPLATATFDLAW 108
Cdd:PLN02244 115 DEKRPKRIVDVGCGIGGSSRYLaRKYGANVKGITLSP---VQAaRANAlAAAQGLSdkvsfqvADALNQPFEDGQFDLVW 191

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446168906 109 SNLAVQWCGNLSTALRELYRVVRPKGVVAFTT 140
Cdd:PLN02244 192 SMESGEHMPDKRKFVQELARVAAPGGRIIIVT 223
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 28-107 1.86e-03

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 38.78  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  28 RQSADALLAMLPQRKYTHVLDAGCGPG---WMSRHWRERHAQVTALDLSPPMLVQARQkdaadhyLAGDIESLPLATATF 104
Cdd:COG5459   66 RAALAELAEAGPDFAPLTVLDVGAGPGtaaWAAADAWPSLLDATLLERSAAALALGRR-------LARAAANPALETAEW 138


                 ...
gi 446168906 105 DLA 107
Cdd:COG5459  139 RLA 141
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 33-110 6.47e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 36.71  E-value: 6.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  33 ALLAMLPQRKYTHVLDAGCGPGWMSRH--WRERHAQVTALDLSpPMLVQARQKDAADH------YLAGDIESlPLATATF 104
Cdd:COG2813   40 LLLEHLPEPLGGRVLDLGCGYGVIGLAlaKRNPEARVTLVDVN-ARAVELARANAAANglenveVLWSDGLS-GVPDGSF 117


                 ....*.
gi 446168906 105 DLAWSN 110
Cdd:COG2813  118 DLILSN 123
PRK14968 PRK14968
putative methyltransferase; Provisional
 34-146 7.29e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.42  E-value: 7.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446168906  34 LLA-MLPQRKYTHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLVQARQKDAADHYLAGDIESL------PLATATFDL 106
Cdd:PRK14968  14 LLAeNAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNNGVEVIrsdlfePFRGDKFDV 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446168906 107 A-----------------WSNLAvqWCGN------LSTALRELYRVVRPKGVVaftTLVQGSL 146
Cdd:PRK14968  94 IlfnppylpteeeeewddWLNYA--LSGGkdgrevIDRFLDEVGRYLKPGGRI---LLLQSSL 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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