NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446174828|ref|WP_000252683|]
View 

MULTISPECIES: transglycosylase SLT domain-containing protein [Enterobacteriaceae]

Protein Classification

transglycosylase SLT domain-containing protein( domain architecture ID 10793850)

transglycosylase SLT domain-containing protein similar to Escherichia coli X polypeptide

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK13722 PRK13722
lytic transglycosylase; Provisional
 28-196 2.23e-118

lytic transglycosylase; Provisional


:

Pssm-ID: 184274 [Multi-domain]  Cd Length: 169  Bit Score: 332.82  E-value: 2.23e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  28 MKKWMLAICLMFINGICEAADCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGI 107
Cdd:PRK13722   1 MKKWMLAICLMFINEICHATDCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828 108 KPEHLTTDPCMNIYTGAYYLAIAFKKWGVSWEAVGAYNAGFRKTERQNQRRLAYASEVYRIYTWIKSSKGIRVPTTKKSL 187
Cdd:PRK13722  81 KPEHLTTDPCMNIYTGAYYLAIAFKKWGVSWEAVGAYNAGFRKTERQNQRRLAYASEVYRIYTGIKSSKGIRIPATKKSL 160


                 ....*....
gi 446174828 188 SQINSVQKN 196
Cdd:PRK13722 161 PEINSVQNN 169
 
Name Accession Description Interval E-value
PRK13722 PRK13722
lytic transglycosylase; Provisional
 28-196 2.23e-118

lytic transglycosylase; Provisional


Pssm-ID: 184274 [Multi-domain]  Cd Length: 169  Bit Score: 332.82  E-value: 2.23e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  28 MKKWMLAICLMFINGICEAADCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGI 107
Cdd:PRK13722   1 MKKWMLAICLMFINEICHATDCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828 108 KPEHLTTDPCMNIYTGAYYLAIAFKKWGVSWEAVGAYNAGFRKTERQNQRRLAYASEVYRIYTWIKSSKGIRVPTTKKSL 187
Cdd:PRK13722  81 KPEHLTTDPCMNIYTGAYYLAIAFKKWGVSWEAVGAYNAGFRKTERQNQRRLAYASEVYRIYTGIKSSKGIRIPATKKSL 160


                 ....*....
gi 446174828 188 SQINSVQKN 196
Cdd:PRK13722 161 PEINSVQNN 169
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 57-171 5.01e-45

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 144.59  E-value: 5.01e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  57 YKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGIKPEHLTTDPCMNIYTGAYYLAIAFKKWGV 136
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKNGSYDIGLMQINSIWLPELARYGITREELLNDPCTNIYVGAWILARNIKRYGN 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446174828 137 SWEAVGAYNAGFRKterqnqRRLAYASEVYRIYTW 171
Cdd:cd13400   81 TWKAVGAYNSGTPK------KNDKYARKVYRIYRR 109
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 53-162 1.78e-19

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 79.66  E-value: 1.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828   53 AGRDYKIDPDLLRAISWKESRYRVNAIgiNPVTGYGsgLMQVDSQHFNELARYGIKPEHLTTDPCMNIYTGAYYLAIAFK 132
Cdd:pfam01464   4 AAQKYGVDPSLLLAIAQQESGFNPKAV--SKSGAVG--LMQIMPSTAKRLGLRVNPGVDDLFDPEKNIKAGTKYLKELYK 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 446174828  133 KWGVSW-EAVGAYNAGF---RKTERQNQRRLAYA 162
Cdd:pfam01464  80 QYGGDLwLALAAYNAGPgrvRKWIKNAGAKDKKL 113
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 53-147 2.70e-12

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 63.48  E-value: 2.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  53 AGRDYKIDPDLLRAISWKESRYRVNAIGinPVtgyG-SGLMQVDSQHFNELA-RYGIKP-EHLTTDPCMNIYTGAYYLAI 129
Cdd:COG0741  110 AAKKYGVDPALVLALIRQESAFNPNAVS--PA---GaRGLMQLMPATARRLGlKLGLGPsPDDLFDPETNIRAGAAYLRE 184

                         90
                 ....*....|....*....
gi 446174828 130 AFKKWGVSWE-AVGAYNAG 147
Cdd:COG0741  185 LLDRFDGDLVlALAAYNAG 203
 
Name Accession Description Interval E-value
PRK13722 PRK13722
lytic transglycosylase; Provisional
 28-196 2.23e-118

lytic transglycosylase; Provisional


Pssm-ID: 184274 [Multi-domain]  Cd Length: 169  Bit Score: 332.82  E-value: 2.23e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  28 MKKWMLAICLMFINGICEAADCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGI 107
Cdd:PRK13722   1 MKKWMLAICLMFINEICHATDCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828 108 KPEHLTTDPCMNIYTGAYYLAIAFKKWGVSWEAVGAYNAGFRKTERQNQRRLAYASEVYRIYTWIKSSKGIRVPTTKKSL 187
Cdd:PRK13722  81 KPEHLTTDPCMNIYTGAYYLAIAFKKWGVSWEAVGAYNAGFRKTERQNQRRLAYASEVYRIYTGIKSSKGIRIPATKKSL 160


                 ....*....
gi 446174828 188 SQINSVQKN 196
Cdd:PRK13722 161 PEINSVQNN 169
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 57-171 5.01e-45

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 144.59  E-value: 5.01e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  57 YKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGIKPEHLTTDPCMNIYTGAYYLAIAFKKWGV 136
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKNGSYDIGLMQINSIWLPELARYGITREELLNDPCTNIYVGAWILARNIKRYGN 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446174828 137 SWEAVGAYNAGFRKterqnqRRLAYASEVYRIYTW 171
Cdd:cd13400   81 TWKAVGAYNSGTPK------KNDKYARKVYRIYRR 109
PRK15328 PRK15328
type III secretion system invasion protein IagB;
30-173 2.41e-31

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 111.50  E-value: 2.41e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  30 KWMLAICLMFINGICEAADCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGIKP 109
Cdd:PRK15328   2 HYFFIIVIWLLSINTAWADCWLQAEKMFNIESELLYAIAQQESAMKPGAIGHNRDGSTDLGLMQINSFHMKRLKKMGISE 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446174828 110 EHLTTDPCMNIYTGAYYLAIAFKKWGVSWEAVGAYNAGFRKtERQNQRRLaYASEVYRIYTWIK 173
Cdd:PRK15328  82 KQLLQDPCISVIVGASILSDMMKIYGYSWEAVGAYNAGTSP-KRSDIRKR-YAKKIWENYRKLK 143
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 53-162 1.78e-19

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 79.66  E-value: 1.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828   53 AGRDYKIDPDLLRAISWKESRYRVNAIgiNPVTGYGsgLMQVDSQHFNELARYGIKPEHLTTDPCMNIYTGAYYLAIAFK 132
Cdd:pfam01464   4 AAQKYGVDPSLLLAIAQQESGFNPKAV--SKSGAVG--LMQIMPSTAKRLGLRVNPGVDDLFDPEKNIKAGTKYLKELYK 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 446174828  133 KWGVSW-EAVGAYNAGF---RKTERQNQRRLAYA 162
Cdd:pfam01464  80 QYGGDLwLALAAYNAGPgrvRKWIKNAGAKDKKL 113
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 53-147 2.70e-12

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 63.48  E-value: 2.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  53 AGRDYKIDPDLLRAISWKESRYRVNAIGinPVtgyG-SGLMQVDSQHFNELA-RYGIKP-EHLTTDPCMNIYTGAYYLAI 129
Cdd:COG0741  110 AAKKYGVDPALVLALIRQESAFNPNAVS--PA---GaRGLMQLMPATARRLGlKLGLGPsPDDLFDPETNIRAGAAYLRE 184

                         90
                 ....*....|....*....
gi 446174828 130 AFKKWGVSWE-AVGAYNAG 147
Cdd:COG0741  185 LLDRFDGDLVlALAAYNAG 203
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 61-147 8.56e-11

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 56.45  E-value: 8.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  61 PDLLRAISWKESRYRVNAigINPVTGYgsGLMQVDSQHFNELARYGikPEHLtTDPCMNIYTGAYYLAIAFKKWGVSWE- 139
Cdd:cd00254    1 PALVLAVIRVESGFNPRA--VSPAGAR--GLMQLMPGTARDLGRRG--VDDL-FDPEENIRAGARYLRELLDRFGGDLEl 73


                 ....*...
gi 446174828 140 AVGAYNAG 147
Cdd:cd00254   74 ALAAYNAG 81
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 53-158 1.45e-07

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 48.63  E-value: 1.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  53 AGRDYKIDPDLLRAISWKESRY------RVNAIginpvtgygsGLMQVDSQHFNELAR-YGIK--PEHLTTDPCMNIYTG 123
Cdd:cd13401   13 AAKKNGLDPALVYAIIRQESAFdpdavsPAGAL----------GLMQLMPATAKDVAKkLGLPyySPRDLFDPEYNIRLG 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446174828 124 AYYLAIAFKKWGVSWE-AVGAYNAGFRKTERQNQRR 158
Cdd:cd13401   83 SAYLAELLDRFDGNPVlALAAYNAGPGRVRRWLKRR 118
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 55-147 1.76e-06

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 45.58  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  55 RDYKIDPDLLRAISWKESRYRVNAIGinpvtGYGS-GLMQVDSQHFNELA-RYGI---KPEHLtTDPCMNIYTGAYYLAI 129
Cdd:cd16896   13 KEYGVDPLLVAAVIKVESNFNPNAVS-----SKGAiGLMQIMPETAEWIAeKLGLedfSEDDL-YDPETNIRLGTWYLSY 86

                         90
                 ....*....|....*....
gi 446174828 130 AFKKWGVSWE-AVGAYNAG 147
Cdd:cd16896   87 LLKEFDGNLVlALAAYNAG 105
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 50-160 1.52e-05

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 43.29  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  50 FDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGygsgLMQVdsqhFNELAR-YGIKPEHlttDPCMNIYTGAYYLA 128
Cdd:cd13403    1 FKKYAEKYGFDWRLLAAQAYQESRFNPNARSPAGARG----LMQL----MPSTAReLGVNDRL---DPEQNIHAGAKYLR 69

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446174828 129 IAFKKW--GVS-----WEAVGAYNAGFRKTErqNQRRLA 160
Cdd:cd13403   70 YLRDRFppDIDepdrlKFALAAYNAGPGHVR--DARRLA 106
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 47-147 8.10e-05

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 41.43  E-value: 8.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  47 ADCFDLAGRDYKIDPDLLRAISWKESRyrvnAIGINPVTGYGS-----GLMQVDSQHfnelarYGIK-----PEHLttDP 116
Cdd:cd01021   38 KDCIKQVGKKLCIDPALIAAIISRESR----AGAALDKNGWGDhgngfGLMQVDKRY------HPPKgawdsEEHI--EQ 105

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446174828 117 CMNIYTGaYYLAIA--FKKWgvSWE-----AVGAYNAG 147
Cdd:cd01021  106 ATGILID-FIKTVQrkHPSW--SPEqqlkgGIAAYNAG 140
LT_VirB1-like cd16892
VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up ...
 59-124 1.40e-04

VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up type IV secretion systems (T4SS). T4SS are macromolecular assemblies generally composed of VirB1-11 and VirD4 proteins, and are used by bacteria to transport material across their membranes. VirB1 acts as a lytic transglycosylase (LT), and is important with respect to piercing the peptidoglycan layer in the periplasm. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381613 [Multi-domain]  Cd Length: 143  Bit Score: 40.22  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  59 IDPDLLRAISWKESRYRVNAIGIN-------PVT--------------GY--GSGLMQVDSQHFnelARYGIKPEHLtTD 115
Cdd:cd16892    9 VHPETLAAIVQVESGGNPYAIGVNggklsrqPKTkaeaiatarqliaaGHnfDVGLGQINSRNL---ARLGLTVEDV-FD 84


                 ....*....
gi 446174828 116 PCMNIYTGA 124
Cdd:cd16892   85 PCTNLKAGA 93
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 55-192 1.61e-03

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 37.54  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  55 RDYKIDPDLLRAISWKESRY------RVNAIginpvtgygsGLMQV--------DSQhfnelaRYGIKPEHLTT----DP 116
Cdd:cd16893    8 KKYGVDPALILAIIETESSFnpyavsHSPAY----------GLMQIvpstagrdVYR------LLGGKGGLPSKsylfDP 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828 117 CMNIYTGAYYLAIAFKKWG------VSWE--AVGAYNAGfrkterqnqrrlayASEVYRIYTwiksskgirvPTTKKSLS 188
Cdd:cd16893   72 ENNIDIGTAYLHILQNRYLkgiknpKSREycAIAAYNGG--------------AGNVLRTFS----------SDRKKAIS 127


                 ....
gi 446174828 189 QINS 192
Cdd:cd16893  128 KINR 131
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
53-196 4.79e-03

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 36.95  E-value: 4.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828  53 AGRDYKIDPDLLRAISWKESRY------RVNAIGinpvtgygsgLMQVdSQH------FNELARYGIKPEHLTTDPCMNI 120
Cdd:PRK11671 199 ASRKYGVDESLILAIMQTESSFnpyavsRSDALG----------LMQV-VQHtagkdvFRMKGKSGQPSRSYLFDPANNI 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446174828 121 YTGAYYLAIAFKKW--GVS------WEAVGAYNAG----FR-----KTERQNQRRLAYASEVYRIYTWIKSSKGIRvptt 183
Cdd:PRK11671 268 DTGTAYLAILQNVYlgGITnptsrrYAVITAYNGGagsvLRvfsndKIQAANIINTMSPGDVYQTLTTRHPSAESR---- 343

                        170
                 ....*....|...
gi 446174828 184 kKSLSQINSVQKN 196
Cdd:PRK11671 344 -RYLYKVNTAQKS 355
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH