|
Name |
Accession |
Description |
Interval |
E-value |
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
6-457 |
3.02e-152 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 441.78 E-value: 3.02e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 6 TESALTPRSLRDTRRMNMFVSVAAAVAGLLFGLDIGVIAGALPFITDHFVLT--------SRLQEWVVSSMMLGAAIGAL 77
Cdd:TIGR00879 10 SELLVTPAGLGSTYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTsansdsysSSLWGLVVSIFLVGGFIGAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 78 FNGWLSFRLGRKYSLMAGAILFVLGSIGS---AFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQ 154
Cdd:TIGR00879 90 FAGWLSDRFGRKKSLLIIALLFVIGAILMglaAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 155 LMVTLGIVLAFLSDTA---FSYSGNWRAMLGVLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTSEKAREE 231
Cdd:TIGR00879 170 LAITFGILVAYGFGSGkvsLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKEL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 232 LNEIR--------ESLKLKQGGWALFKINRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTtEQQMIATLVV 303
Cdd:TIGR00879 250 LDELElidikrsiEKRSVQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVST-DHAFLVSIIV 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 304 GLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGYCLMQFDNGtASSGLSWLSVGMTMMCIAGYAMSAAPVVWIL 383
Cdd:TIGR00879 329 GAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTG-SSKSSGNVAIVFILLFIAFFAMGWGPVPWVI 407
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446178582 384 CSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIGAAGTFWLYTALNIAFVGITFWLIPETKNVTLEHI 457
Cdd:TIGR00879 408 VSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
25-459 |
4.90e-137 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 402.04 E-value: 4.90e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 25 VSVAAAVAGLLFGLDIGVIAGALP---FITDHFVLTSR--------LQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLM 93
Cdd:pfam00083 1 VALVAALGGFLFGYDTGVIGAFLTlidFFKNFGLSKSVsslaalsvLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 94 AGAILFVLGSIGSAFAT---SVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTA 170
Cdd:pfam00083 81 IANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 171 FSYSGN---WRAMLGVLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTSEkAREELNEIRESLKLKQGG-- 245
Cdd:pfam00083 161 LNKTSNsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPD-VDRELDEIKDSLEAGQEAek 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 246 --WALFKINRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTeqqMIATLVVGLTFMFATFIAVFTVDKAGR 323
Cdd:pfam00083 240 asWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS---FLVTIIVGVVNFVFTFIAIFLVDRFGR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 324 KPALKIGFSVMALGTLVLGYClmqFDNGTA-SSGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTT 402
Cdd:pfam00083 317 RPLLLLGAAGMAICFVILGIV---ALLGVSkSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATA 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 446178582 403 TNWVSNMIIGATFLTLLDSIGAAGTFWLYTALNIAFVGITFWLIPETKNVTLEHIER 459
Cdd:pfam00083 394 ANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDE 450
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
28-448 |
2.14e-122 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 361.51 E-value: 2.14e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 28 AAAVAGLLFGLDIGVIAGALPFITD--HFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIG 105
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKdlGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 106 SAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYS--GNWRAMLGV 183
Cdd:cd17315 81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSppGWWRLMFAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 184 LALPAVLLIILVVFLPNSprwlaekgrhieaeevlrmlrdtsekareelneireslklkqggwalfkinrnvrRAVFLGM 263
Cdd:cd17315 161 AAVPALLQLLLMFFLPES-------------------------------------------------------RALLVGV 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 264 LLQAMQQFTGMNIIMYYAPRIFKMAGftTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGY 343
Cdd:cd17315 186 GLQLLQQLTGINAVMYYAPTIFKSAG--GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAI 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 344 CLMqfdNGTASSGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIG 423
Cdd:cd17315 264 AFL---LPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIG 340
|
410 420
....*....|....*....|....*
gi 446178582 424 AAGTFWLYTALNIAFVGITFWLIPE 448
Cdd:cd17315 341 LAGVFIFFAAVCLLALVFVFFFVPE 365
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
24-448 |
1.98e-107 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 323.75 E-value: 1.98e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 24 FVSVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGS 103
Cdd:cd17359 1 LISLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 104 IGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGN------- 176
Cdd:cd17359 81 LGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGadwlgae 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 177 -WRAMLGVLALPAVLLIILVVFLPNSPRWLAEKGrhieaeevlrmlrdtsekareelneireslklkqggwalfkinrnv 255
Cdd:cd17359 161 gWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKG---------------------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 256 RRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFtTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMA 335
Cdd:cd17359 195 KPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGF-SENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMA 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 336 LGTLVLGYClMQFDNGTASSGlsWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATF 415
Cdd:cd17359 274 ISLLLIGTA-FYFAPGSQASG--IVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTF 350
|
410 420 430
....*....|....*....|....*....|...
gi 446178582 416 LTLLDSIGAAGTFWLYTALNIAFVGITFWLIPE 448
Cdd:cd17359 351 PILLAAFGLAFTFLIFAVICVLAFLFVWKFVPE 383
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
28-448 |
3.83e-93 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 286.47 E-value: 3.83e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 28 AAAVAGLLFGLDIGVIAGALPFITDHF---VLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSI 104
Cdd:cd17360 1 FAGIGGFLFGYDTGVISGALLYIKDDLgevVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 105 GSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSY-SGNWRAMLGV 183
Cdd:cd17360 81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYlPGGWRWMLGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 184 LALPAVLLIILVVFLPNSPRWlaekgrhieaeevlrmlrdtsekareelneireslklkqggwalfkinRNVRRAVFLGM 263
Cdd:cd17360 161 AAVPAVLQFIGLLFLPESPRW------------------------------------------------PSTRRALIVGC 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 264 LLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGy 343
Cdd:cd17360 193 GLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVVLA- 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 344 clmqfdngtassglSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIG 423
Cdd:cd17360 272 --------------VWLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIG 337
|
410 420
....*....|....*....|....*.
gi 446178582 424 AAGTFWLYTALN-IAFVGITFWLiPE 448
Cdd:cd17360 338 PYGTFLLFAGLAvLGLIFIYFCV-PE 362
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
24-456 |
8.97e-92 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 285.62 E-value: 8.97e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 24 FVSVAAAVAGLLFGLDIGVIAGALPFITD----HFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILF 99
Cdd:cd17358 2 LATFVANLGSFSFGIAVGWSSPALPSLMSdnslSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 100 VLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFsysgNWRA 179
Cdd:cd17358 82 ILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----PWRT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 180 MLGVLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTSEKAREELNEIRESLK-----LKQGGWALFKiNRN 254
Cdd:cd17358 158 LALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAelekeAKESSFSDLF-QRK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 255 VRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQqmIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVM 334
Cdd:cd17358 237 YLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPN--TATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGM 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 335 ALGTLVLG-YCLMQFDNGTASSgLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGA 413
Cdd:cd17358 315 GIGLLALGlYFYLQEHGALLSS-VSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTK 393
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 446178582 414 TFLTLLDSIGAAGTFWLYTAlnIAFVGITF--WLIPETKNVTLEH 456
Cdd:cd17358 394 TFPFLTLAWGASGTFWIFAG--ICGLALVFvlLFVPETKGKSLEE 436
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
29-457 |
3.12e-82 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 259.21 E-value: 3.12e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 29 AAVAGLLFGLDIGVIAGALPFI-------TDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVL 101
Cdd:cd17362 2 PALGGLLFGYDIGATSGALLSItspalsgTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 102 GSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAF-SYSGNWRAM 180
Cdd:cd17362 82 GSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFaDVVGGWRYM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 181 LGVLALPAVLLIILVVFLPNSPRWlaekgrhieaeevlrmlrdtsekareelneireslklkqggwalfkiNRNVRRAVF 260
Cdd:cd17362 162 YGLAAPPALLLGIGMWFLPPSPRW-----------------------------------------------QGNYRKPLI 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 261 LGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLV 340
Cdd:cd17362 195 IGLGLVLFQQITGQPSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSGMVVSLFL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 341 LGYCLMQFDNGTAssGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLD 420
Cdd:cd17362 275 LAAYNLFVQMGPA--GLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQE 352
|
410 420 430
....*....|....*....|....*....|....*..
gi 446178582 421 SIGAAGTFWLYTALNIAFVGITFWLIPETKNVTLEHI 457
Cdd:cd17362 353 LIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
23-459 |
1.98e-80 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 257.31 E-value: 1.98e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 23 MFVSVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQE--------WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMA 94
Cdd:PRK10077 11 FSITLVATLGGLLFGYDTAVISGTVESLNTVFVAPQNLSEsaansllgFCVASALIGCIIGGALGGYCSNRFGRRDSLKI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 95 GAILFVLGSIGSAF------------ATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIV 162
Cdd:PRK10077 91 AAVLFFISALGSAWpefgftsigpdnTGYVPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 163 LAFL--------SDTAFSYSGNWRAMLGVLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTsEKAREELNE 234
Cdd:PRK10077 171 VVYFvnyfiarsGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGN-TLATQALQE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 235 IRESLKLKQ-GGWALFKINRNVrraVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGfTTTEQQMIATLVVGLTFMFATFI 313
Cdd:PRK10077 250 IKHSLDHGRkTGGKLLMFGVGV---IVIGVMLSVFQQFVGINVVLYYAPEIFKTLG-ASTDIALLQTIIVGVINLTFTVL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 314 AVFTVDKAGRKPALKIGFSVMALGTLVLGYCLmqfdnGTASSGLswLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCR 393
Cdd:PRK10077 326 AIMTVDKFGRKPLQIIGALGMAIGMFSLGTAF-----YTQAPGI--VALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIR 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446178582 394 DFGITCSTTTNWVSNMIIGATF------LTLLDSIGAAGTFWLYTALNIAFVGITFWLIPETKNVTLEHIER 459
Cdd:PRK10077 399 GKALAIAVAAQWIANYFVSWTFpmmdknSWLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEMEA 470
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
28-455 |
1.05e-71 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 232.85 E-value: 1.05e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 28 AAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQE----WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGS 103
Cdd:cd17433 6 AAVLGPLSFGFVLGYSSPAIPSLQRIADPALRLDDaaasWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 104 IGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYsgNWRAMLGv 183
Cdd:cd17433 86 TVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLDW--RWLAVLG- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 184 lALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTSEKAREELNEIRESLKLKQGGWALFKI-NRNVRRAVFLG 262
Cdd:cd17433 163 -SIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEQSFHLEEQSFSLALLkQPGIYKPLIIG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 263 MLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEqqmIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLG 342
Cdd:cd17433 242 VSLMAFQQLTGINAVMFYAETIFEEAKFKDSS---VASVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVFSTAAFG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 343 yclmqfdngtassglsWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSI 422
Cdd:cd17433 319 ----------------WLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVLTNWLMAFLVTKEFSSLMEVL 382
|
410 420 430
....*....|....*....|....*....|...
gi 446178582 423 GAAGTFWLYTALNIAFVGITFWLIPETKNVTLE 455
Cdd:cd17433 383 SSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLE 415
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
24-459 |
6.32e-69 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 225.21 E-value: 6.32e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 24 FVSVAAAVAGLLFGLDIGVIAGAL---------PFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMA 94
Cdd:cd17356 1 LLCAFVSLGGFLFGYDTGSISGILnmksfqkyfADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 95 GAILFVLGSIGSAFAT-SVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSY 173
Cdd:cd17356 81 GCVIYIIGAIIQVAAIgKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 174 SGN---WRAMLGVLALPAVLLIILVVFLPNSPRWLaekgrhieaeevlrmlrdtsekareelneireslklkqggwalfk 250
Cdd:cd17356 161 LDGsaqWRIPLGLQIVWGLLLLIGMFFLPESPRWL--------------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 251 inrnvrRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEqQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIG 330
Cdd:cd17356 196 ------YRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGSS-PLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIG 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 331 FSVMALGTLVLGYCLMQFDNGTASSGLSWLSVGMTMMC-----IAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNW 405
Cdd:cd17356 269 AAGMSICLFIYAAVGVRYLIPNPQSGTSNKSAGNGMIVficlfIFSFATTWGPIAWVYVAEVFPLRVRSKGMALATAFNW 348
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 446178582 406 VSNMIIGATFLTLLDSIGaAGTFWLYTALNIAFVGITFWLIPETKNVTLEHIER 459
Cdd:cd17356 349 LWNFLISFFTPFIIGSIG-FKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDE 401
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
64-451 |
1.00e-65 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 218.28 E-value: 1.00e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 64 VVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSI---GSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEM 140
Cdd:cd17357 54 IVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLlmfLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEI 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 141 ASENVRGKMISMYQLMVTLGIVLA--FLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLPNSPRWLA-EKGRHIEAEEV 217
Cdd:cd17357 134 SPSELRGALGSLTQIGVTLGILLGqvFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLiSKGDEEEAEKS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 218 LRMLRDTSEKAREELNEIR-ESLKLKQGG----WALFKiNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFtT 292
Cdd:cd17357 214 LKFLRGIEDDVDQELEEIKkESEQMGDQKqvslMQLLR-DPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGF-S 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 293 TEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGYCLMQFDNgtaSSGLSWLSVGMTMMCIAGY 372
Cdd:cd17357 292 PQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQ---NSWMSYGCIVAIFLFIFFF 368
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446178582 373 AMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIGAAgTFWLYTALNIAFVGITFWLIPETKN 451
Cdd:cd17357 369 AIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGF-VFIIFAIPCALFLLYLYRYLPETKG 446
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
26-457 |
4.30e-63 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 209.27 E-value: 4.30e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 26 SVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIG 105
Cdd:cd17435 3 SVTAAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 106 SAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAF-SYSGNWRAMLGVL 184
Cdd:cd17435 83 LVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFaNVSNGWKYMFGLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 185 ALPAVLLIILVVFLPNSPRWLaekgrhieaeevlrMLRDtsekareelneireslklkqggwalfkinrNVRRAVFLGML 264
Cdd:cd17435 163 IPLAALQAIAMYFLPPSPRFL--------------VMKD------------------------------NMRARLLIGLT 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 265 LQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGyc 344
Cdd:cd17435 199 LVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVSLVTMG-- 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 345 lmqfdngtassglSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIGA 424
Cdd:cd17435 277 -------------LWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTELIGL 343
|
410 420 430
....*....|....*....|....*....|...
gi 446178582 425 AGTFWLYTALNIAFVGITFWLIPETKNVTLEHI 457
Cdd:cd17435 344 PWVCFIYTAMSLASLVFVIMFVPETKGCSLEQI 376
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
29-457 |
7.75e-63 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 208.79 E-value: 7.75e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 29 AAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAF 108
Cdd:cd17437 2 ASLNSILLGYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 109 ATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFS---YSGNWRAMLGVLA 185
Cdd:cd17437 82 APNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSglpLHVGWRLMLGVGA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 186 LPAVLLIILVVFLPNSPRWlaekgrhieaeevlrmlrdtsekareelneireslklkqggwalfkiNRNVRRAVFLGMLL 265
Cdd:cd17437 162 VPSLFLAIGVLAMPESPRW-----------------------------------------------TPAVRRMLIAALGI 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 266 QAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPAL--KIGFSVMALGTLVLGY 343
Cdd:cd17437 195 HFFQQASGIDAVVLYSPRIFKKAGIKSKDKLLLATVAVGVTKTLFILVATFLLDKVGRRPLLltSTGGMTLSLTALATSL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 344 CLMQFDNGTASSGLSwLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIG 423
Cdd:cd17437 275 TFIDRNGGGLTWALV-LAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAIT 353
|
410 420 430
....*....|....*....|....*....|....
gi 446178582 424 AAGTFWLYTALNIAFVGITFWLIPETKNVTLEHI 457
Cdd:cd17437 354 TGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
29-451 |
6.35e-57 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 194.86 E-value: 6.35e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 29 AAVAGLLFGLDIGVIAGALPFITDHF--VLTSRLQE----------WVVSSMM--LGAAIGALFNGWLSFRLGRKYSLMA 94
Cdd:cd17431 6 AVLGSLQFGYNTGVINAPQKVIEEFYnkTLGDRYGEpispetlttlWSLSVAIfsVGGMIGSFSVGLFVNRFGRRNSMLY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 95 GAILFVLGSIGSAF---ATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA--FLSDT 169
Cdd:cd17431 86 NNLLAFAGAALMGLsklAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISqiFGLEF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 170 AFSYSGNWRAMLGVLALPAVLLIILVVFLPNSPRWL-AEKGRHIEAEEVLRMLR---DTSEKAREELNEIRESLKLKQGG 245
Cdd:cd17431 166 ILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLlINRNEEEEAKSVLKKLRgttDVSEDIQEMKEESRQMMREKKVT 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 246 W-ALFKiNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGfttTEQQMIATLVVGLTFMFATFIAVFTVDKAGRK 324
Cdd:cd17431 246 IlELFR-SSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAG---VQQPVYATIGAGVVNTIFTVVSLFLVERAGRR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 325 PALKIGFSVMALGTLVLGYCLMQFDNgtaSSGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTN 404
Cdd:cd17431 322 TLHLIGLGGMAICAILMTIALLLLEG---YPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSN 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 446178582 405 WVSNMIIGATFLTLLDSIGAAgTFWLYTALNIAFVGITFWLIPETKN 451
Cdd:cd17431 399 WTSNFIVGMCFQYIANLCGPY-VFIIFTVFLLTFFIFTYFKVPETKG 444
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
28-448 |
1.02e-56 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 192.85 E-value: 1.02e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 28 AAAVAGLLFGLDIGVIAGAL---PFITDHFVLTSRLQEWV----------------VSSMMLGAAIGALFNGWLSFRLGR 88
Cdd:cd17361 1 VAALGGLIFGYDIGISGGVTsmdPFLEKFFPSVYEKKKGAsennyckyddqllqlfTSSLYLAGLVASLLASYVTRKWGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 89 KYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSD 168
Cdd:cd17361 81 KPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 169 TAFSYSG--NWRAMLGVLALPAVLLIILVVFLPNSPrwlaekgrhieaeevlrmlrdtsekareelneireslklkqggw 246
Cdd:cd17361 161 YGTSKIKpnGWRLSLGLAAVPALILLLGSLFLPETP-------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 247 alfkinrnVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFtTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPA 326
Cdd:cd17361 197 --------NSPQLVIAILIPFFQQLTGINVIMFYAPVLFQTLGF-GSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 327 LKIGFSVMALGTLVLGYCLMQFDNGTASSGLSWLSVGMTMMCI--AGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTN 404
Cdd:cd17361 268 LLEGGVQMLASQVAIGILLAVKFGDGGELPKAYAIAVVVLICLyvAAFAWSWGPLGWLVPSEIFPLETRSAGQSLTVAVN 347
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 446178582 405 WVSNMIIGATFLTLLDSIgAAGTFWLYTALNIAFVGITFWLIPE 448
Cdd:cd17361 348 FLFTFVIAQAFLSMLCAM-KFGIFLFFAGWVVVMSLFVYFLLPE 390
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
31-457 |
3.26e-52 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 180.38 E-value: 3.26e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 31 VAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFAT 110
Cdd:cd17436 8 LGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 111 SVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFS-YSGNWRAMLGVLALPAV 189
Cdd:cd17436 88 SFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSnVLTGWRYMFGLAIIPAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 190 LLIILVVFLPNSPRWLAekgrhieaeevlrmLRDtsekareelneireslklkqggwalfkinrNVRRAVFLGMLLQAMQ 269
Cdd:cd17436 168 IQFASILLLPKKPEVLN--------------IKD------------------------------NMRRRTLVGLGLVLFQ 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 270 QFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGYclmqfd 349
Cdd:cd17436 204 QFTGQPNVLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGIGL------ 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 350 ngtassglsWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIGAAGTFW 429
Cdd:cd17436 278 ---------WITLLCLMAFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFLDLIDVIGLSWTFL 348
|
410 420
....*....|....*....|....*...
gi 446178582 430 LYTALNIAFVGITFWLIPETKNVTLEHI 457
Cdd:cd17436 349 LYGVVGVAGVVFIYLFVPETKGQSLEEI 376
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
64-457 |
1.92e-51 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 180.50 E-value: 1.92e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 64 VVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAF---ATSVEMLIAARVVLGIAVGIASYTAPLYLSEM 140
Cdd:cd17432 55 TVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLskiAKSFEMIIVGRFLVGINAGISLNVVPMYLGES 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 141 ASENVRGKMISMYQLMVTLGIVLA---FLSDTAFSYSGnWRAMLGVLALPAVLLIILVVFLPNSPRW-LAEKGRHIEAEE 216
Cdd:cd17432 135 APKNLRGAVGLVPAIFITLGILLGqvlGLRELLGNEEG-WPLLLALTGVPALLQLLTLPFFPESPRYlLIEKGDEEAARK 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 217 VLRMLRDtSEKAREELNEIRESLKLKQGG-----WALFKiNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFT 291
Cdd:cd17432 214 ALQRLRG-KEDVDDEMEEMLEEQRAEKGVgtvsvLELFR-DRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIP 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 292 TTEQQMiATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGYCLMQFDNgtaSSGLSWLSVGMTMMCIAG 371
Cdd:cd17432 292 EDKIQY-VTVGTGACEVLATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALSLQNT---VSWMPYLSIVCIFAYIAS 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 372 YAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIGAA-----GTFWLYTALNIAFVgitfwlI 446
Cdd:cd17432 368 FGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLNWLSNFLVGLLFPFIQEGLGAYcflvfAVICLLTAIYIFFV------L 441
|
410
....*....|.
gi 446178582 447 PETKNVTLEHI 457
Cdd:cd17432 442 PETKGKTFLEI 452
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
63-455 |
2.03e-43 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 158.07 E-value: 2.03e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMAS 142
Cdd:cd17434 45 WFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISH 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 143 ENVRGKMISMYQLMVTLGIVLAFlsdtAFSYSGNWRAMLGVLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLR 222
Cdd:cd17434 125 PGVRGALGACPQIMAVFGSLALY----ALGLLLPWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLR 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 223 DTSEKAREELNEIRESLkLKQG---GWALFKiNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIA 299
Cdd:cd17434 201 GPNTDYMTEFEQIKDNI-RKQSsrlSWAELK-TPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAVILEPKYDAA 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 300 tlVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGYCLMQfdngtassglswlsvgMTMMCIAGYAMSAAPV 379
Cdd:cd17434 279 --LVGAVRLLSVAIAASLMDKAGRKILLFTSAFLMFAANLSMGLIPLI----------------AAMLFIMGYAMGWGPI 340
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446178582 380 VWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIGAAGTFWLYTALNIAFVGITFWLIPETKNVTLE 455
Cdd:cd17434 341 TWLLMSEILPLKARGVASGLCVVVSWITAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLE 416
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-383 |
9.80e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 127.40 E-value: 9.80e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 17 DTRRMNMFVSVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGA 96
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 97 ILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGN 176
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 177 WRAMLGVLALPAVLLIILVVFLpnsprwlaekgrhieaeevlrMLRDTSEKAREELNEIRESLKlkqggwalfkinrnvR 256
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRL---------------------LPESRPAARARLRGSLRELLR---------------R 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 257 RAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTeQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAL 336
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS-AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446178582 337 GTLVLGYclmqfdngtaSSGLSWLSVGMTMMCIAGYAMSAAPVVWIL 383
Cdd:COG2814 286 GLLLLAL----------AGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
20-206 |
6.09e-31 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 121.07 E-value: 6.09e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 20 RMNMFVSVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILF 99
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 100 VLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRA 179
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170 180
....*....|....*....|....*..
gi 446178582 180 MLGVLALPAVLLIILVVFLPNSPRWLA 206
Cdd:COG0477 170 IFLINAPLGLLALVLRLRLPESRGLLL 196
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-445 |
6.40e-24 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 102.29 E-value: 6.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 27 VAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQE--WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSI 104
Cdd:cd17316 2 LLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQtgLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 105 GSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSG----NWRAM 180
Cdd:cd17316 82 LIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 181 LGVLALPAVLLIILvvflpnsprwlaekgrhieaeevlrmlrdtsekareelneireslklkqggwalfkinrnvRRAVF 260
Cdd:cd17316 162 FLIGALPALLALLL-------------------------------------------------------------RRRTL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 261 LGMLLQAMQQFtGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLV 340
Cdd:cd17316 181 LLILLWFFISF-GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 341 LGYCLmqfdngtassGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGItcSTTTNWVSNMIIGATFL--TL 418
Cdd:cd17316 260 LFYLL----------SGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGV--GLSYNLGRLGGGGAPPLiaLL 327
|
410 420
....*....|....*....|....*..
gi 446178582 419 LDSIGAAGTFWLYTALnIAFVGITFWL 445
Cdd:cd17316 328 LASTGGTGVPALILAL-LAIVALIVAL 353
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
13-325 |
3.98e-23 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 100.89 E-value: 3.98e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 13 RSLRDTRRMNMFVSVAAAVAGLLF---GLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRK 89
Cdd:TIGR00895 3 QNNIRKQPLSRYQWRAIILSFLIMlmdGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 90 YSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-FLSD 168
Cdd:TIGR00895 83 RVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGgFLAG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 169 TAFSYSGnWRAMLGV-LALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTSEKAREELNEIRESLKLKQGGWA 247
Cdd:TIGR00895 163 WLIPVFG-WRSLFYVgGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 248 LFKINRNVRRAVFLGMLlqamqqfTGMNIIMYYA-----PRIFKMAGFTTTeQQMIATLVVGLTFMFATFIAVFTVDKAG 322
Cdd:TIGR00895 242 ALFQGKTARITVLLWLL-------YFMLLVGVYFltnwlPKLMVELGFSLS-LAATGGALFNFGGVIGSIIFGWLADRLG 313
|
...
gi 446178582 323 RKP 325
Cdd:TIGR00895 314 PRV 316
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
29-444 |
1.68e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 98.65 E-value: 1.68e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 29 AAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAF 108
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 109 ATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAF--SYSGNWRAMLGVLAL 186
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 187 PAVLLIILVVFLPNSPRWLAEKGrhieaeevlrmlrdtsekareelNEIRESLKLKQGGWALFKinrnvRRAVFLGMLLQ 266
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAK-----------------------NEEASSKSVLKLLKRVLK-----NPGLWLLLLAI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 267 AMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGYclm 346
Cdd:cd06174 213 FLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLL--- 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 347 qfdngtassGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIGAAG 426
Cdd:cd06174 290 ---------APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLT 360
|
410
....*....|....*...
gi 446178582 427 TFWLYTALNIAFVGITFW 444
Cdd:cd06174 361 GAFLVLAVLLLLAAILLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-383 |
4.83e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 97.23 E-value: 4.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 28 AAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSA 107
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 108 FATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWR-AMLGVLAL 186
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRaAFLAIAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 187 PAVLLIILVVFLPNSPRwlaekgrhieaeevlrmlrdtsekareelnEIRESLKLKQGGWALFKiNRNVRRAVFLGMLLq 266
Cdd:cd17324 163 ALLAALLLWRLLPSLPP------------------------------KKPGSLGLLSSLLLLLR-NPRLRLAYLITFLL- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 267 amqqFTGMNIIM-YYAPRIFKMAGFTTTeQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGycl 345
Cdd:cd17324 211 ----FGGFFALYtYLAPFLTDVPGFSSS-AIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTL--- 282
|
330 340 350
....*....|....*....|....*....|....*...
gi 446178582 346 mqfdngtASSGLSWLSVGMTMMCIAGYAMSAAPVVWIL 383
Cdd:cd17324 283 -------LGPSPLLLLVGLVLWGLGFFAAHSALQTRVL 313
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-450 |
4.14e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 94.55 E-value: 4.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 16 RDTRRMNMFVSVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAG 95
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 96 AILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSG 175
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 176 NWRAMLGVLALPAVLLIILvvflpnsprwlaekgrhieaeevlrmlrdtsekareelneireslklkqggwalfkinrnv 255
Cdd:COG2271 162 GWRAAFLILGLPGLLLALL------------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 256 rraVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGR--KPALKIGFSV 333
Cdd:COG2271 181 ---RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 334 MALGTLVLGYclmqfdngtassgLSWLSVGMTMMCIAGYAMSAA-PVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIG 412
Cdd:COG2271 258 AALALLLLAL-------------LPSPALAIALLFLAGFGLGGAfGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP 324
|
410 420 430
....*....|....*....|....*....|....*...
gi 446178582 413 ATFLTLLDSIGAAGTFWLYTALNIAFVGITFWLIPETK 450
Cdd:COG2271 325 LLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
30-378 |
8.82e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 93.25 E-value: 8.82e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 30 AVAGLLFGLDIGVIAGALP-FITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAF 108
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 109 ATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPA 188
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 189 VLLIILVVFLPNSPrwlaekgrhieaeevlrmlrdtsekareelnEIRESLKLKQGGWALFKINRNVRRAVFLGMLLQAM 268
Cdd:pfam07690 162 LLAAVLLLLPRPPP-------------------------------ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 269 QQFTGMNIIMYYAPRIFKMAGFTTteqqMIATLVVGLTFMFATFIAVFT---VDKAGRKPALKIGFSVMALGTLVLGYCL 345
Cdd:pfam07690 211 LFGFAFFGLLTYLPLYQEVLGLSA----LLAGLLLGLGGLLGAIGRLLLgrlSDRLGRRRRLLLALLLLILAALGLLLLS 286
|
330 340 350
....*....|....*....|....*....|....*
gi 446178582 346 MQFDNGTASSGLSWLSVGMTMM--CIAGYAMSAAP 378
Cdd:pfam07690 287 LTLSSLWLLLALLLLGFGFGLVfpALNALVSDLAP 321
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
46-341 |
1.01e-18 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 87.63 E-value: 1.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 46 ALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIA 125
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 126 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLpnsprwl 205
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLF------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 206 aekgrhieaeevlrmlrdtsekareeLNEIRESLKLKQGGWALFKINRNV-RRAVFLGMLLQAMQQFTGMNIIMYYAPRI 284
Cdd:cd17320 174 --------------------------LPETLPEEKRKPLLSSLLRAYKRVlKNRRFLGYALALGLSFAGLFAYLAAAPFI 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 446178582 285 FKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVL 341
Cdd:cd17320 228 YIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVL 284
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
66-455 |
3.47e-18 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 86.99 E-value: 3.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 66 SSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENV 145
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 146 RGKMISMYQLMVTLGIVlaFLSDTAFsYSGNWRAMLGVLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDT- 224
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLV--LLPLVAY-FIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKIn 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 225 -----SEKAREELNEIRESLKLKQGGWALFKiNRNVRRAVFLGMLLqamqqFTGMNIIMYYAPRIFKMAGFTTTEQQMIA 299
Cdd:TIGR00898 291 gkklpAEVLSLSLEKDLSSSKKQYSFLDLFR-TPNLRKTTLCLMML-----WFTTAFSYYGLVLDLGNLGGNIYLDLFIS 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 300 TLVVgltfMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGYClmqfdngtaSSGLSWLSVGMTMMCIAGyAMSAAPV 379
Cdd:TIGR00898 365 GLVE----LPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFV---------PVDLYFLRTALAVLGKFG-ITSAFQM 430
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446178582 380 VWILCSEIQPLKCRDFGITCSTTTNWVSNMIigATFLTLLDSIGAAGTFWLYTALNIAFVGITFWLiPETKNVTLE 455
Cdd:TIGR00898 431 VYLYTAELYPTVVRNLGVGVCSTMARVGSII--SPFLVYLGEKWLFLPLVLFGGLALLAGILTLFL-PETKGVPLP 503
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-446 |
4.89e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.32 E-value: 4.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 30 AVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFA 109
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 110 TSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAV 189
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 190 LLIILVVFLPnsprwlaekgrhieaeevlrmlrdtsEKAREELNEIRESLKLKQGGWALFKINRNVrRAVFLGMLLQAMQ 269
Cdd:cd17325 162 LALVLALLLL--------------------------PEPRPPPNKRAVSAARLRSGLRLLLRDRRL-LALFLAIFVLAFA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 270 QFTGMNIIMYYAPRIFKMagftTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGYclmqfd 349
Cdd:cd17325 215 FGALEPFLPLYAAELGGL----SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL------ 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 350 ngtaSSGLSWLSVGMTMMCIaGYAMSAAPVVWILCSEIQPlkcRDFGITCST-TTNWVSNMIIGATFLTLL-DSIGAAGT 427
Cdd:cd17325 285 ----ATSFWLLLLLLALLGL-GLGLVFPATLALLADIVPP---EGRGTAMGLfNTAFSLGMVLGPLLGGFLyDAFGFATP 356
|
410
....*....|....*....
gi 446178582 428 FWLYTALNIAFVGITFWLI 446
Cdd:cd17325 357 FLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
30-195 |
2.26e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 83.38 E-value: 2.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 30 AVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFA 109
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 110 TSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAV 189
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161
|
....*.
gi 446178582 190 LLIILV 195
Cdd:cd17321 162 VALLLA 167
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
37-229 |
5.08e-17 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 83.87 E-value: 5.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 37 GLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLI 116
Cdd:TIGR01299 180 GVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 117 AARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA--------------FLSDTAFSYSgNWRAMLG 182
Cdd:TIGR01299 260 FCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAaamawaiiphygwsFQMGSAYQFH-SWRVFVI 338
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 446178582 183 VLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTSEKAR 229
Cdd:TIGR01299 339 VCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNMRAK 385
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-452 |
1.11e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 81.47 E-value: 1.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 27 VAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGS 106
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 107 AFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLAL 186
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 187 PAVLLIILV-VFLPNSPrwlaekgrhieaeevlrmlRDTSEKAREELNEIRESLKLKQgGWALFkinrnvrrAVFLGMll 265
Cdd:COG2223 168 LLLVVAVLAwLFLRDPP-------------------AGAAAAAKASLRDQLEALRDPR-FWLLS--------LLYFGT-- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 266 qamqqFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGYCL 345
Cdd:COG2223 218 -----FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 346 MQFdngtassglsWLSVGMTMMCIAGYAMSAApVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIGA- 424
Cdd:COG2223 293 GSL----------WLFLVLFLLLGLALGGGNG-AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSy 361
|
410 420
....*....|....*....|....*...
gi 446178582 425 AGTFWLYTALNIAFVGITFWLIPETKNV 452
Cdd:COG2223 362 TAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
37-229 |
1.82e-16 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 81.38 E-value: 1.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 37 GLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLI 116
Cdd:cd17363 12 GVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 117 AARVVLGIAVGIASYTAPLYLSEMASENVRGKMIS----------MYQLMVTLGIV----LAFLSDTAFSYSgNWRAMLG 182
Cdd:cd17363 92 FCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSwlcmfwmiggLYASAMAWAIIphygWGFSMGTAYQFH-SWRVFVI 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 446178582 183 VLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTSEKAR 229
Cdd:cd17363 171 VCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNMRAK 217
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
64-449 |
5.30e-16 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 79.63 E-value: 5.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 64 VVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFA------TSVEMLIAARVVLGIAVGIASYTAPLYL 137
Cdd:cd17364 44 VNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSpgstplGVMGWLIFFRFLLGIGIGGDYPLSATIM 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 138 SEMASENVRGKMISMYQLMVTLGIVLA--------------FLSDTAFSYSGNWRAMLGVLALPAVLLIILvvflpnspr 203
Cdd:cd17364 124 SEYANKKRRGALIAAVFAMQGFGILAGaivtlilsaifehpLPAGTYHHADLVWRIVLGLGAIPALSVLYF--------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 204 wlaekgrhieaeevlrmlrdtsekareelneiRESLKLKQGGWALFKInrnvrravflgmllqamqQFTGMNIimyYAPR 283
Cdd:cd17364 195 --------------------------------RKHLLGTAGTWFLLDI------------------AFYGQNL---FQST 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 284 IFKMAGFTTT-----EQQMIATLVVGLTFMFAT---FIAVFTVDKAGRKPALKIGFSVMALGTLVLGYCLMQFDNGTAss 355
Cdd:cd17364 222 IISAIGFSKTmnayqELFNIAVGQLIIALAGTVpgyWFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYDHWKISTI-- 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 356 glswLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIGAAGTFWLYTALN 435
Cdd:cd17364 300 ----GFFVLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVA 375
|
410
....*....|....
gi 446178582 436 IAFVGITFWLIPET 449
Cdd:cd17364 376 LLGIILTLLFPEEK 389
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
30-221 |
6.27e-16 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 79.24 E-value: 6.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 30 AVAgLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFA 109
Cdd:PRK11551 22 LVA-LLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 110 TSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLAL-PA 188
Cdd:PRK11551 101 WDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVgPL 180
|
170 180 190
....*....|....*....|....*....|...
gi 446178582 189 VLLIILVVFLPNSPRWLAEKGRHIEAEEVLRML 221
Cdd:PRK11551 181 LLVPLLMRWLPESRAFAQAAGAGKQRAPVLRAL 213
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
27-340 |
6.91e-16 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 79.27 E-value: 6.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 27 VAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGS 106
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 107 AFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-FLSDTAFSYSGN---WRAMLG 182
Cdd:cd17371 82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLAtLLAALLFPLLPPeiaWRVLFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 183 VLALPAVLLIILVVFLPNSPRWLAEKGRhieaeevlrmlrdtsekareelneiRESLKLKQGGWALFkiNRNVRRAVFLG 262
Cdd:cd17371 162 LGALPALLVLFIRRFVKEPPQWQAARAA-------------------------RRHFADRPSLRELF--SPPLLRTTLLA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 263 MLLQAMQQFTgmniimYYAPRIFkMAGFTTTEQQMIATLVVGLTFMFA------TFIAVFTVDKAGRKPALKIGFSVMAL 336
Cdd:cd17371 215 SLLATGALGG------YYGITTW-LPSYLTGERGLSFEGSAGYLVVTIlggflgYLAGGFLADRIGRRNNFALFALGSAI 287
|
....
gi 446178582 337 GTLV 340
Cdd:cd17371 288 SILL 291
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
34-196 |
2.99e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 76.86 E-value: 2.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 34 LLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVE 113
Cdd:cd17365 9 VLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 114 MLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLII 193
Cdd:cd17365 89 QLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP 168
|
...
gi 446178582 194 LVV 196
Cdd:cd17365 169 LLR 171
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
37-243 |
8.29e-15 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 76.49 E-value: 8.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 37 GLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLI 116
Cdd:cd17440 12 GVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 117 AARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA--------------FLSDTAFSYSgNWRAMLG 182
Cdd:cd17440 92 FCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYAsamawaiiphygwsFSMGSAYQFH-SWRVFVI 170
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446178582 183 VLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTSEKAREELNEIRESLKLKQ 243
Cdd:cd17440 171 VCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTNMRARGQPEKVFTVNRIKK 231
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
60-445 |
9.11e-15 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 75.31 E-value: 9.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 60 LQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSE 139
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 140 MASENVRGKMISMYQLMVTLGIV-LAFLSdtafSYSGNWRAMLGVLALPAVLLIILVVFLPnsprwlaekgrhieaeevl 218
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMlLALLA----YLIRDWRWLQLAISLPGLLFLLLLWWLP------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 219 rmlrdtsekareelneireslklkqggwalfkinrnvRRAVFLGMLLqamqqftGMNIIMYYA--PRIFKMAGfttteQQ 296
Cdd:cd17317 163 -------------------------------------RRTIIVGLIW-------FVTSLVYYGlsLNSSNLGG-----NL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 297 MIATLVVGLTFMFATFIAVFTVDKAGRKPALkigFSVMALGTLVLGYCLMQFDNgtassglsWLSVGMTMMCIAGYAMSA 376
Cdd:cd17317 194 YLNFFLSGLVEIPAYFLALLLLDRLGRRWTL---SGSLLLAGLACLVTALLPDD--------ENTLALTLALVGKFAISA 262
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446178582 377 A-PVVWILCSEIQPLKCRDFGI-TCSTttnwVSNM-IIGATFLTLLDSIGAAGTFWLYTALNIAFVGITFWL 445
Cdd:cd17317 263 AfSVIYLYTAELYPTVVRNTGVgLCST----VARVgAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLL 330
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
40-342 |
1.45e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 74.92 E-value: 1.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 40 IGVIAGALPFITDHFVLTSRLQ-EWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAA 118
Cdd:cd17473 15 GAAIAPALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 119 RVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSySGNWRAMLGVLALPAVLLIILVVFL 198
Cdd:cd17473 95 RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLLFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 199 PNSPRwlaekgrhieaeevlrmlrdTSEKAREELNEIRESLKLKQGGWALFkinrnvrrAVFLGMLLqamqqftgMNIIM 278
Cdd:cd17473 174 PEPAR--------------------KSKSAASPGAATAAALPWKRVLPIYF--------LAFLAMLL--------FYVIP 217
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446178582 279 YYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLG 342
Cdd:cd17473 218 IQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLA 281
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-203 |
3.35e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 74.14 E-value: 3.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 8 SALTPRSLRDTRRMNMFVSVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLG 87
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 88 RKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVrGKMISMYQLMVTLGIVLAFLS 167
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGL 160
|
170 180 190
....*....|....*....|....*....|....*..
gi 446178582 168 DTAFSYSGNWRAMLGVLALPAVL-LIILVVFLPNSPR 203
Cdd:COG2807 161 TVPLAAALGWRGALAVWALLALLaLLLWLPLLRRRPA 197
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
37-231 |
4.22e-14 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 74.19 E-value: 4.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 37 GLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLI 116
Cdd:cd17438 12 GVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 117 AARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA--------------FLSDTAFSYSgNWRAMLG 182
Cdd:cd17438 92 FCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYAsamawsiiphygwgFSMGTNYHFH-SWRVFVI 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 446178582 183 VLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTSEKAREE 231
Cdd:cd17438 171 ICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNMRAKGT 219
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
31-195 |
5.17e-14 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 72.98 E-value: 5.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 31 VAGLLFGLDIGVIAGALPFITDHFVLTSRLQeWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFAT 110
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 111 SVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAM------LGVL 184
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCfyinlpIGGL 161
|
170
....*....|.
gi 446178582 185 ALPAVLLIILV 195
Cdd:cd17502 162 ALALLRTILLS 172
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
31-211 |
2.08e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 71.50 E-value: 2.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 31 VAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFAT 110
Cdd:cd17328 6 LINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 111 SVEMLIAARVVLGIavGIASYT--APLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAF-SYSGNWRAMLGVLALP 187
Cdd:cd17328 86 NFWQLLLFRALVGI--GEASYSpiAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVL 163
|
170 180
....*....|....*....|....*
gi 446178582 188 AVLL-IILVVFLPNSPRWLAEKGRH 211
Cdd:cd17328 164 GVLLaILLLLFVREPPRGAAEGGVM 188
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
74-450 |
2.48e-13 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 71.56 E-value: 2.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 74 IGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVE--------MLIAARVVLGIAVGIASYTAPLYLSEMASENV 145
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYAtigiwapiILLLARLLQGLSVGGEYGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 146 RGKMISMYQLMVTLGIVLAFLSDTAFSY--------SGNWRAMLGVLALPAVLLIILVVFLPNSprwlaekgrhieaeev 217
Cdd:cd17367 135 RGFYSSFQYVTLIGGQLLALGVLLVLQHtlgedqmaAWGWRIPFLLGGVLAVVVLWLRRGLEET---------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 218 lrmlrdtsekarEELNEIRESLKLKQGGWALFkinRNVRRAVFLGMLLQAmqqftGMNIIMY----YAPRIFKMAGFTTT 293
Cdd:cd17367 199 ------------ESFEAIAESNEASAGTLREL---RRHPRELLLVVGLTA-----GGTLAFYtwttYLQKFLVNTAGFSK 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 294 EQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALkIGFSVmaLGTLVLGYCLMQFDNGTASSGLswLSVGMTMMCIAGYA 373
Cdd:cd17367 259 GDATWITTAALLVFMLLQPLGGRLSDRIGRRPLL-LFFGI--GGTLATVPLLSALDHTDSPYTA--FALVLVGLVFLSGY 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 374 MSAAPVVWilcSEIQPLKCRDFGITCSTTtnwVSNMIIGAT---FLTLLDSIGAAGTFWLYTALNIAFVGITFWLIPETK 450
Cdd:cd17367 334 TSINAVVK---AELFPTHVRALGVGLPYA---LAVAIFGGTapyVALWLKSIGHEWVFFWYVAGLIAISLVVYLRMPETR 407
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-341 |
4.24e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 70.65 E-value: 4.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 18 TRRMNMFVSVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAI 97
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 98 LFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENvRGKMISMYQLMVTLGIVLAFLSDTAFSYSG-- 175
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 176 -NWRAMLGVLALPAVLLIILVVFLPnsprwlaekgrhieaeevLRMLRDTSEKAREELNEIRESLKLKQGGWALFkinrn 254
Cdd:COG0738 161 lSWHLPYLILAVLLLLLALLFLRSK------------------LPEIEEEEEEAAGSAASLKSLLKNPRLLLGGL----- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 255 vrrAVFLGMLLQAMqqftgmniIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVM 334
Cdd:COG0738 218 ---AIFLYVGAEGA--------IGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLA 286
|
....*..
gi 446178582 335 ALGTLVL 341
Cdd:COG0738 287 AVGLLLA 293
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
31-343 |
5.15e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.32 E-value: 5.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 31 VAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFAT 110
Cdd:cd17489 3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 111 SVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-FLSDTAFSYSGNWraMLGVLALPAV 189
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGpALGLFLYQHLGFA--VLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 190 LLIILVVFLpnsprwlaekgrhieaeevlrMLRDTSEKAREELNEIRESLKLkqggwalfkinrnVRRAVFLGMLLQAMQ 269
Cdd:cd17489 161 LLALLLVFL---------------------VKDPPPVAAEEAEAGTRAFRRL-------------VEKKVLPPALILFLA 206
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446178582 270 QFTGMNII----MYYAPRIFKMAGFTTTeqqmiatlVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGY 343
Cdd:cd17489 207 SIAYGAIStflpLYAAERGISNAGLFFT--------VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF 276
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
27-343 |
1.33e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 69.14 E-value: 1.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 27 VAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGS 106
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 107 AFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVL-----AFLSDTAfsysgnWRAML 181
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVgpllgGLLAAIS------WRYPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 182 GVLALPAVLLIILVVFLPNSPRwlaEKGRHIEAEEVLRMLRdtsekareelneireslklkqggwalfkinrNVRRAVFL 261
Cdd:cd17474 156 FLLAALIPVAFLAILFLLPEPK---EKAKSSSATKLRDLKK-------------------------------ALRGRGLL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 262 GMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFM-FATFIAVFTVDKAGRKPALKIGFSVMALGTLV 340
Cdd:cd17474 202 TFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLAlGSLFVGRLLKKRFGARRILVIGLLLYALSLLL 281
|
...
gi 446178582 341 LGY 343
Cdd:cd17474 282 LGF 284
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
29-378 |
1.90e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 68.37 E-value: 1.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 29 AAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAF 108
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 109 ATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-----FLSDTAfsysgNWRAMLGV 183
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGptlggWLTDNL-----SWRWIFYI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 184 LALPAVLLIILVVFLPnsprwlaekgrhieaeevLRMLRDtsekareelneireslklkqggwalfkinRNVRRAVFLGM 263
Cdd:cd17503 156 NLPIGILALLLAPLLD------------------LRLFKD-----------------------------RNFTLGLLLSF 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 264 LLQAmqqftGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVlgy 343
Cdd:cd17503 189 LLGL-----GLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLL--- 260
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 446178582 344 cLMQFDNGTASSGLSW------LSVGMTMMCIAGYAMSAAP 378
Cdd:cd17503 261 -LAFLTPDTSLWLIILplfirgLGMGLVFMPLNTLALNSLP 300
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
5-198 |
8.85e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.45 E-value: 8.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 5 NTESALTPRSLRDTRRMNMFVsVAAAVAGLLFGLDIGVIAGALP-FITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLS 83
Cdd:cd17325 181 RAVSAARLRSGLRLLLRDRRL-LALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLS 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 84 FRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVL 163
Cdd:cd17325 260 DRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVL 339
|
170 180 190
....*....|....*....|....*....|....*
gi 446178582 164 AFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFL 198
Cdd:cd17325 340 GPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
42-200 |
9.31e-12 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 66.44 E-value: 9.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 42 VIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVV 121
Cdd:cd17323 17 IYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 122 LGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLA-LPAVLLIILVVFLPN 200
Cdd:cd17323 97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAiISGFCLILIFLFLPI 176
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
30-195 |
2.21e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 65.29 E-value: 2.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 30 AVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFA 109
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 110 TSVEMLIAARVVLGIAVGIasytAPLYLSeMASENVRGKMISMYQLMVT----LGIVLAFLSDTAFSYSGNWRAMLGVLA 185
Cdd:cd17504 82 PNLPVLIAGRALQGIGGAV----FPLAFA-LVREEFPPERVPVAQGILSatfgIGAGIGLPLGGWIVQHLGWRWIFWTAA 156
|
170
....*....|
gi 446178582 186 LPAVLLIILV 195
Cdd:cd17504 157 PVAVLLAALV 166
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
42-210 |
7.90e-11 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 64.18 E-value: 7.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 42 VIAGALPFITDHFvLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVV 121
Cdd:cd06179 16 LPAAVLPFIVADL-GPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 122 LGIAVGIASYTAPLyLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAF--SYSGNWRAMLGVLALPAVLLIILVVFLP 199
Cdd:cd06179 95 IGIGAGTQGLGAAV-ASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNALALILLFFFY 173
|
170
....*....|.
gi 446178582 200 NSPRWLAEKGR 210
Cdd:cd06179 174 HPPPRPQLHGS 184
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
37-229 |
1.84e-10 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 62.74 E-value: 1.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 37 GLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLI 116
Cdd:cd17439 12 GVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 117 AARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA--------------FLSDTAFSYSgNWRAMLG 182
Cdd:cd17439 92 FCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYAsamawaiiphygwsFQMGSAYQFH-SWRVFVL 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 446178582 183 VLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTSEKAR 229
Cdd:cd17439 171 VCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAK 217
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
56-459 |
2.56e-10 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 62.44 E-value: 2.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 56 LTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAF-----ATSVEMLIAA-RVVLGIAVGIA 129
Cdd:TIGR00887 53 LPSSVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLspgssPKSVMATLCFwRFWLGVGIGGD 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 130 SYTAPLYLSEMASENVRGKMISMY-------QL---MVTLGIVLAF-------------LSDTAFSYSGNWRAMLGVLAL 186
Cdd:TIGR00887 133 YPLSAIITSEFATKKWRGAMMAAVfamqgfgILagaIVALIVLAGFkhsleaaadeascTGSCVPAVDYMWRILIGFGAV 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 187 PAVLLIILVVFLPNSPRWLAEKGRHIE--AEEVLRMLRDTSEKAREELNEIRESLKLKQGGWALFkINRNVRRAVFLGML 264
Cdd:TIGR00887 213 PALLALYFRLTIPETPRYTADVAKDVEqaASDMSAVLQVKIEAEPDEVEKASTAVEVPKASWSDF-FTHFFKWRHGKHLL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 265 LQAMQQFTgMNIIMY----YAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIA-----------VFTVDKAGRKPALKI 329
Cdd:TIGR00887 292 GTAGSWFL-LDIAFYgvnlNQKVILSAIGYSPPAATNNAYEELYKTAVGNLIIAlagtvpgywvtVFLVDIIGRKPIQLM 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 330 GFSVMALGTLVLGYCLmqfdNGTASSGLswlsvgMTMMCIAGYAMSAAP--VVWILCSEIQPLKCRDFGITCSTTTNWVS 407
Cdd:TIGR00887 371 GFFILTVLFFVLGFAY----NHLSTHGF------LAIYVLAQFFANFGPnaTTFIVPGEVFPTRYRSTAHGISAASGKAG 440
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446178582 408 NMIIGATFLTLLDSIGAAGTF----WLYTALNI----AFVGITF-WLIPETKNVTLEHIER 459
Cdd:TIGR00887 441 AIIGQFGFLYLAQHGDPTKGYptgiWMGHVLEIfalfMFLGILFtLLIPETKGKSLEELSG 501
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
31-210 |
5.71e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 60.65 E-value: 5.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 31 VAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFAT 110
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 111 SVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVL 190
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLAL 162
|
170 180
....*....|....*....|
gi 446178582 191 LIILVVFLPNSPRWLAEKGR 210
Cdd:cd17477 163 VPLLLTRRAAPEIEEAESIS 182
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
66-203 |
7.86e-10 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 60.68 E-value: 7.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 66 SSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENV 145
Cdd:PRK11043 48 SLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQK 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 446178582 146 RGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLPNSPR 203
Cdd:PRK11043 128 ANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKK 185
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
38-198 |
7.88e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 60.28 E-value: 7.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 38 LDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIA 117
Cdd:cd17319 17 LDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 118 ARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVF 197
Cdd:cd17319 97 LRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWF 176
|
.
gi 446178582 198 L 198
Cdd:cd17319 177 Y 177
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
23-197 |
1.95e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 59.70 E-value: 1.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 23 MFVSVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLG 102
Cdd:TIGR00711 1 LLLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 103 SIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLG 182
Cdd:TIGR00711 81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
|
170
....*....|....*
gi 446178582 183 VLALPAVLLIILVVF 197
Cdd:TIGR00711 161 INVPIGIIVVVVAFF 175
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
49-194 |
2.55e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 58.74 E-value: 2.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 49 FITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGI 128
Cdd:cd17473 223 LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGL 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446178582 129 ASYTAPLYLSEMASENVRGKMISMYQLMVTLG-----IVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIIL 194
Cdd:cd17473 303 LLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGqflspLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
25-164 |
2.63e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.83 E-value: 2.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 25 VSVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSI 104
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 105 GSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA 164
Cdd:COG2814 289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-198 |
2.70e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 58.78 E-value: 2.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 20 RMNMFVSVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILF 99
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 100 VLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRA 179
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*....
gi 446178582 180 MLGVLALPAVLLIILVVFL 198
Cdd:cd06173 365 VFLLAGALLLLAALLLLLL 383
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
46-203 |
2.87e-09 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 58.54 E-value: 2.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 46 ALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIA 125
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 126 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTL-GIVLAFLSDTAFSYSGNWRAMLGVLALPAVLL-IILVVFLPNSPR 203
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVsLICFLLLRDSPQ 176
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
46-198 |
3.58e-09 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 58.55 E-value: 3.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 46 ALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIA 125
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446178582 126 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFL 198
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFI 179
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
46-198 |
4.07e-09 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 58.39 E-value: 4.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 46 ALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIA 125
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446178582 126 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFL 198
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFF 165
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-198 |
1.17e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.22 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 13 RSLRDTRRMNMFVSVAAAVAGLLFGLDIgVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSL 92
Cdd:COG2211 219 ESLKALLKNRPFLLLLLAYLLFFLALAL-VAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAF 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 93 MAGAILFVLGSIGSAFA--TSVEMLIAARVVLGIAVGIASYTAPLYLSEMA-------SENVRGKMISMYQLMVTLGIVL 163
Cdd:COG2211 298 IIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLGQAL 377
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 446178582 164 A------------FLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFL 198
Cdd:COG2211 378 AgalaglllalfgYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLL 424
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
8-198 |
2.49e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.65 E-value: 2.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 8 SALTPRSLRDTRRMNMFVSVAAAVAGLLFGLdiGVIAGALPFITDHFVLTSRLQE-WVVSSMMLGAAIGALFNG-WLSFR 85
Cdd:cd17474 184 SATKLRDLKKALRGRGLLTFLVSAFLYFFLY--FAFLTYLPFLLELLYGISPIIIgLLFAGWSVLLALGSLFVGrLLKKR 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 86 LGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAF 165
Cdd:cd17474 262 FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGP 341
|
170 180 190
....*....|....*....|....*....|...
gi 446178582 166 LSDTAFSYSGNWRAMLGVLALPAVLLIILVVFL 198
Cdd:cd17474 342 LLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
28-209 |
1.91e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 53.16 E-value: 1.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 28 AAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSA 107
Cdd:PRK03893 24 AAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 108 FATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGK----MISMYqlmvTLGIVLAFLSDTAFSYSGNWRAMLGV 183
Cdd:PRK03893 104 FAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKasgfLISGF----SIGAVVAAQVYSLVVPVWGWRALFFI 179
|
170 180
....*....|....*....|....*.
gi 446178582 184 LALPAVLLIILVVFLPNSPRWLAEKG 209
Cdd:PRK03893 180 GILPIIFALWLRKNLPEAEDWKEKHA 205
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
66-342 |
1.98e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 52.99 E-value: 1.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 66 SSMMLGAAIG------ALFN---GWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGI----AVGIAsyt 132
Cdd:cd17472 30 TPTLIGLALGiygltqAIFQipfGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSgaisSVVMA--- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 133 aplYLSEMASENVRGKMismyqlMVTLGIVLAFLSDTAFSYSGNWRAMLGV-------LALPAVLLIILVVFLPNSPRwl 205
Cdd:cd17472 107 ---LLADLTREENRTKA------MALIGASIGIAFAISMVLGPLLAAHLGVsglflitAILSLVSLLILLFFVPDPPK-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 206 AEKGRHIEAEEVLRMLRDtsekareelneireslklkqggWALFKINrnvrravFLGMLLQAMqqftgMNIIMYYAPRIF 285
Cdd:cd17472 176 IVQISEKEKKKLKKLLKN----------------------KRLLRLD-------FSIFILHFV-----LMAFFYILPLLL 221
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 446178582 286 KMAGFTTTEQQMIATLVVGLTFmFATFIAVFTVDKAGR-KPALKIGFSVMALGTLVLG 342
Cdd:cd17472 222 TQLGGGKGQLWKVYLPAILIGF-ILMVPFVIYAEKKGKmKQVFVSSILLIAVGFLLLL 278
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
44-218 |
2.09e-07 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 53.52 E-value: 2.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 44 AGALPFITDHfVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLG 123
Cdd:pfam06609 64 ASALPNILQD-IGQSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 124 IAVGIASyTAPLYLSEMASENVR--GKMISMYQLMVTLGIVLAFlsDTAFSYSGNWRAMLGVLALPAVLLIILVVFLPNS 201
Cdd:pfam06609 143 VAAGPAG-ASPLFIGELMSNKTKflGLLIVSAPTIAMNGAGPYF--GQRLAIQGNWRWIFYIYIIMSAIAVLLIIIWYHP 219
|
170
....*....|....*..
gi 446178582 202 PRWLAEKGRHIEAEEVL 218
Cdd:pfam06609 220 PSFAQLHGKKARKRDEL 236
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
34-198 |
4.09e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.94 E-value: 4.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 34 LLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVE 113
Cdd:cd17333 6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 114 MLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLII 193
Cdd:cd17333 86 LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAI 165
|
....*
gi 446178582 194 LVVFL 198
Cdd:cd17333 166 LILLT 170
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
80-223 |
7.25e-07 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 51.37 E-value: 7.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 80 GWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTL 159
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446178582 160 GIVLAFLSDTAFSYSGNWRAMLGVLAlpAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRD 223
Cdd:PRK15403 152 APIIGPLSGAALMHFVHWKVLFAIIA--VMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRN 213
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
26-199 |
1.58e-06 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 50.23 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 26 SVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIG 105
Cdd:cd17372 1 LAYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 106 SAFATSVEMLIAARVVLGIAVGIASYTAPLYLsEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLA 185
Cdd:cd17372 81 SAFAPNYMWLIILRCLVGLGLGGGPQLASWYL-EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSS 159
|
170
....*....|....
gi 446178582 186 LPAVLLIILVVFLP 199
Cdd:cd17372 160 VPSSLLLVFYRWTP 173
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
26-223 |
2.09e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.93 E-value: 2.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 26 SVAAAVAGLLFGLDIGVIAgalPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIG 105
Cdd:cd17475 1 ATLAQAAASLVAQGIPALA---PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 106 SAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLA 185
Cdd:cd17475 78 MALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAG 157
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 446178582 186 LPAVLL-IILVVFLPNSPRWLAEKGR-HIEAEEVLRMLRD 223
Cdd:cd17475 158 LVSILAaVLFWLFYREPPAASAATESaSTLLRSLKEVLRN 197
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
74-376 |
3.49e-06 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 49.06 E-value: 3.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 74 IGALFNGWLSFRLGRKYSLMA-----GAILFVLG------SIGSAFATsveMLIAARVVLGIAVGIASYTAPLYLSEMAS 142
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLtlllmGIATFLIGllptyaQIGILAPI---LLVLLRLLQGLALGGEWGGAVLMAVEHAP 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 143 ENVRGKMISMYQLMVTLGIVLA---------FLSDTAFSYSGnWRamlgvlaLPAVLLIILVVFlpnsprwlaekG---- 209
Cdd:cd17369 136 PKRRGFYGSFPQLGAPVGLLLAtgvflllsaLLSDEAFLSWG-WR-------IPFLLSAVLVAV-----------Glyir 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 210 RHIEAEEVLRMLRDTSEKAREELNEIReslklkqggwalfkinRNVRRAVFLGMLLQAMQQ---FTGMNIIMYYAPRIFK 286
Cdd:cd17369 197 LRLEETPVFRRAKEAGQVVRAPLVEVL----------------RRHWRALLLAIGLRLAENvlfYLFTTFALSYATQTLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 287 MAGFTTTEQQMIATLVVGLTFMFATFIAvftvDKAGRKPALKIGfsvmALGTLVLGYCLMQFdngtASSGLSWLSVgMTM 366
Cdd:cd17369 261 VDRSTVLLAVLIASVVAAITIPLFGWLS----DRVGRRPVYLAG----ALLAALFAFPFFWL----LDTGSTWLIV-LAA 327
|
330
....*....|
gi 446178582 367 MCIAGYAMSA 376
Cdd:cd17369 328 VVVLGVLHGM 337
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
56-205 |
3.49e-06 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 49.04 E-value: 3.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 56 LTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPL 135
Cdd:cd17441 31 LPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVTL 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 136 YlSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLPNSPRWL 205
Cdd:cd17441 111 Y-AEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVLCFWLPESARYW 179
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
60-199 |
4.35e-06 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 48.44 E-value: 4.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 60 LQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAV-GIASYTAPLyLS 138
Cdd:cd17374 36 LKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVsGISINTLIL-GT 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446178582 139 EMASENVRGKMISMYQLMVTLGIVLafLSDTAFSYSgNWRAMLGVLALPAVLLIILVVFLP 199
Cdd:cd17374 115 EWTTPRHRALAITLTSCFFSIGQML--LAGLAYAIR-DWRLLQLVVSVPFFLFFLYSWWLP 172
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
46-341 |
5.47e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 5.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 46 ALPFITDHFVLTSrlqeWVVSSMMLGAAIGALFN----GWLS----FRLGRKYS-LMAGAILFVLGSIGSAFATSVE--- 113
Cdd:COG2211 33 LLYFYTDVLGLSA----ALVGLILLVARLWDAITdpliGALSdrtrTRWGRRRPwILIGAIPLALSFVLLFTAPDLSptg 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 114 ---MLIAARVVLGIAVGIAS--YTAplYLSEMASE-NVRGKMISMYQLMVTLGIVLA------FLSDTAFSYSGNWRAML 181
Cdd:COG2211 109 kliYALVTYLLLGLAYTLVNipYSA--LGAELTPDyEERTRLSSWRFAFAGLGGLLAsvlpppLVAAFGGDAALGYRLTA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 182 GVLALPAVLLIILVVFLpnsprwlaekgrhieaeevlrmlrdtsekAREELNEIRESLKLKQGGWALFKiNRNVRRaVFL 261
Cdd:COG2211 187 LIFAVLGLLAFLLTFFG-----------------------------TKERPVPEEEKVSLKESLKALLK-NRPFLL-LLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 262 GMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTeqqmIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVL 341
Cdd:COG2211 236 AYLLFFLALALVAALLLYYFKYVLGLSAALVG----LLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
41-203 |
6.85e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.94 E-value: 6.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 41 GVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARV 120
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 121 VLGIAVGIASYTAPLYLSEMASENvRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLPN 200
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP 171
|
...
gi 446178582 201 SPR 203
Cdd:cd17478 172 LKK 174
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-164 |
1.00e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 1.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 27 VAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGS 106
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGL 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446178582 107 AFATSVE---MLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA 164
Cdd:pfam07690 283 LLLSLTLsslWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
74-449 |
1.44e-05 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 47.37 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 74 IGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVE--------MLIAARVVLGIAVGIASYTAPLYLSEMASENV 145
Cdd:cd17368 55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYAtigiaaplLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 146 RGKMISM----YQLMVTLGIVLAFLSDTAFSY----SGNWRA--MLGVLALPAVLLIILVvfLPNSPRWLAEKgRHIEAE 215
Cdd:cd17368 135 RGFYTSWqsasQQVAIVAGALVGYLLSLTLTAealaEWGWRIpfFIGLLIIPLGLWLRRS--LEETEAFLERK-ARPTRR 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 216 EVLRMLrdtsekareelneireslklkqggwalfkinRNVRRAVFLGMLLQAMQQFTgMNIIMYYAPRIFKMAGFTTTEQ 295
Cdd:cd17368 212 ELFALL-------------------------------ANNRRIILLGMLLVAGSTVT-FYFTTVYTPTYAKTVLGLSARD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 296 QMIATLVVGLTFMFATFIAVFTVDKAGRKPALkigfSVMALGTLVLGYCLMQFDngTASSGLSWLSVGMTMMCIAGyAMS 375
Cdd:cd17368 260 SFLVTLLAGVANFIWAPLGGALSDRIGRRPVL----LVITLAALVTLYPVFAWL--TAAPSFGRLLLVLLVLSFFF-GMY 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 376 AAPVVwILCSEIQPLKCRDfgiTCSTTTNWVSNMIIG------ATFLTLLDSIGAAGTFWLYTAlniAFVG-ITFWLIPE 448
Cdd:cd17368 333 GGAMV-VALVELFPVRVRS---TGFSLVYALAVAIFGgfaqfiVTWLIELTGSPLAPAWYLMGA---ALLGlLATLMLRE 405
|
.
gi 446178582 449 T 449
Cdd:cd17368 406 T 406
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
71-199 |
1.45e-05 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 47.08 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 71 GAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMI 150
Cdd:cd17377 51 GVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECVGKSYWALAG 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446178582 151 SMYQLMVTLGIvlAFLSDTAFsYSGNWRAMLGVLALPAVLLIILVVFLP 199
Cdd:cd17377 131 SLGGLFFAVGI--AQYALLGY-FIRSWRTLAVVVNLQGTLVFLLSLFIP 176
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
46-205 |
1.80e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.88 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 46 ALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIA 125
Cdd:cd17312 25 AKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 126 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWR-AMLGVLALPAVLLIILVVFLPNSPRW 204
Cdd:cd17312 105 QSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRaAFLVPGIVGLVVAIILFFFLRDSPPY 184
|
.
gi 446178582 205 L 205
Cdd:cd17312 185 V 185
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
37-208 |
2.68e-05 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 46.46 E-value: 2.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 37 GLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLI 116
Cdd:PRK12307 31 GFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 117 AARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVV 196
Cdd:PRK12307 111 LSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRA 190
|
170
....*....|..
gi 446178582 197 FLPNSPRWLAEK 208
Cdd:PRK12307 191 RAPESKEWEEAK 202
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
66-199 |
3.16e-05 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 45.81 E-value: 3.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 66 SSMMLGAAIGALFNGWLS-FRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASEN 144
Cdd:cd17378 40 SSFFVGCLIGSGVLGHLAdSSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPK 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 446178582 145 VRGKMISMYQLMVTLGIvlAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLP 199
Cdd:cd17378 120 WRGQVGMSTFFFFVLGF--MSLPGIAYLNGSSWRVLYFWTSIPALIYCILVYLFA 172
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
68-190 |
3.52e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 3.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 68 MMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRG 147
Cdd:cd17370 243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG 322
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 446178582 148 KMISMYQLMVTLGIVLA-----FLSD-----TAFSYSgnwrAMLGVLALPAVL 190
Cdd:cd17370 323 TAYGLFNTVVGIGWLLAsliagYLWDlispsAAFLFS----AVLALIALLLLL 371
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
70-199 |
5.18e-05 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 45.11 E-value: 5.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 70 LGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAV-GIASYTAPLYLS--EMASENVR 146
Cdd:cd17447 46 AGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALtGFSIISMVLCVEwvDIEHRTVA 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 446178582 147 GKMISmyqLMVTLGIVLafLSDTAFsYSGNWRAMLGVLALPAVLLIILVVFLP 199
Cdd:cd17447 126 GVLIS---LFWTVGNML--LALVAY-LIRDWRWLILAVTLPCAPGIITWWWVP 172
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
85-198 |
6.44e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.91 E-value: 6.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 85 RLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA 164
Cdd:cd17329 262 RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIG 341
|
90 100 110
....*....|....*....|....*....|....
gi 446178582 165 FLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFL 198
Cdd:cd17329 342 PLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
55-377 |
6.46e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.90 E-value: 6.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 55 VLTSRLQEWVVSSMMLGAAIGA---------LFNGWLSFRLG-RKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGI 124
Cdd:cd17490 18 FLSPYAESLGASLSMIGIILGAygisqmllrIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 125 AVGI-ASYTApLYLSEMASENVrGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLPNSPR 203
Cdd:cd17490 98 AAATwVSFTV-LYASYFPPDEA-AKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 204 wlaekgrhieaeevlrmlrdTSEKAREELNEIRESLKlkqggwalfkiNRNVRRAVFLGMLlqamQQFTGMNIIMYYAPR 283
Cdd:cd17490 176 --------------------EKKPVLTELKELLSVLK-----------DKKLLFFSLLAIL----QQMITFSTTFGFTPL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 284 IFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGY-------CLMQFDNGTASSG 356
Cdd:cd17490 221 IAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFapnltllYLLQALNGFGTGI 300
|
330 340
....*....|....*....|.
gi 446178582 357 LSWLSVGMTMMCIAGYAMSAA 377
Cdd:cd17490 301 LFPLLMSLSIEGVPAEQRSTA 321
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
47-205 |
9.47e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.49 E-value: 9.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 47 LPFITDHFV---LTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLG 123
Cdd:cd17330 19 LPFYVREFNklgASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 124 IAVGIASyTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLPNSPR 203
Cdd:cd17330 99 LTGGNVS-VAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLR 177
|
..
gi 446178582 204 WL 205
Cdd:cd17330 178 RL 179
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
66-198 |
9.52e-05 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 44.63 E-value: 9.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 66 SSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENV 145
Cdd:PRK10473 45 SVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRR 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446178582 146 RGKMISMYQ----LMVTLGIVLAFLSDTAFSysgnWRAMLGVLALPAVLLIILVVFL 198
Cdd:PRK10473 125 RAKVLSLLNgitcIIPVLAPVLGHLIMLKFP----WQSLFYTMAAMGILVLLLSLFI 177
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
70-199 |
1.08e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 44.37 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 70 LGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGI---ASYTaplYLSEMASENVR 146
Cdd:COG2270 285 IVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGiqaLSRS---LLARLIPPGRE 361
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 446178582 147 GKMISMYQLMVTLGIVLA-FLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLP 199
Cdd:COG2270 362 AEFFGLYALSGKAASFLGpLLFGLVTQLTGSQRLGILSLIVFFVIGLVLLLRVK 415
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
47-223 |
1.22e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 47 LPFITDHFVLTSRLQEWVVSSMM----LGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVL 122
Cdd:cd17329 19 WPFMAIYLHQQLGLSASIVGLVLalsaVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 123 GIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVL-AFLSDTAFSYSGNWRAMLGVLALpAVLLIILVVFLPNS 201
Cdd:cd17329 99 GFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIgPLLGGLLLLYSFRLLFLAAAVLF-LLAALVLLFLLPET 177
|
170 180
....*....|....*....|..
gi 446178582 202 PRWLAEKGRHIEAEEVLRMLRD 223
Cdd:cd17329 178 RPKRRAAEKTEILRGYKIVLRD 199
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
63-198 |
1.66e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.71 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAG-AILFVLGSIGSAFATSVEMLIAArVVLGIAVGIASYTAPLYLSEMA 141
Cdd:COG2807 254 LLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLlGLLGLAGLLGLLLAPGSLPWLWA-VLLGLGQGGLFPLALTLIGLRA 332
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446178582 142 -SENVRGKMISMyqlMVTLGIVLAFLSDTAFSY----SGNWRAMLGVLALPAVLLIILVVFL 198
Cdd:COG2807 333 rTPAEAAALSGM---AQSVGYLLAALGPLLVGAlhdaTGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
63-344 |
1.73e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 43.78 E-value: 1.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMAS 142
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 143 ENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGN------WRAML---GVLALPAVLLIILvvFLPNSP---RWLAEKGR 210
Cdd:cd17327 125 REEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGvgglagWRWLFiieGLITIIIGLVIFF--WLPDNPskaWFLTEEEK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 211 HIEAEEVLRMLRDTSEKaREELNEIRESLKlkqggwalfkinrnvrRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGF 290
Cdd:cd17327 203 ELAVERLRANQTGKGDQ-KFKWKQIKEAFK----------------DPRTWLLFLFFFCSQITNNGISNFLPLILKSLGF 265
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 446178582 291 TTTEQQMIATLVVGLTFMFATFIAVFTvDKAGRKPALKIGFSVMAL-GTLVLGYC 344
Cdd:cd17327 266 YSLQTNLLSVPIGALGAVSLLIAALLS-DRFKKRGLFAIFACVLALvGSIILLAA 319
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
27-204 |
1.91e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.41 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 27 VAAAVAGLLFGLDIGVIAGALPF---ITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGS 103
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFiipIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 104 IGSAFATSVEMLIAARVVLGIA-VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLG-IVLAFLSDTAFSYSGnWRAML 181
Cdd:cd17355 83 VLLALATSLWQLYLLWGLLGGGgAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGsLVFLPLGAALIEAFG-WRTAL 161
|
170 180
....*....|....*....|...
gi 446178582 182 GVLALPAVLLIILVVFLPNSPRW 204
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRPA 184
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
25-195 |
2.18e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.31 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 25 VSVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSI 104
Cdd:cd17324 200 LRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 105 GSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENvRGKMISMYQLMVTLGIVL-AFLSDTAFSYSGnWRAMLGV 183
Cdd:cd17324 280 LTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALgAALGGLVLDHGG-WAGVGWV 357
|
170
....*....|..
gi 446178582 184 LALPAVLLIILV 195
Cdd:cd17324 358 GAALLLLALLLA 369
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
66-199 |
2.23e-04 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 43.11 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 66 SSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENV 145
Cdd:cd17379 40 SSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 446178582 146 RGKMISMYQLMVTLGIVLafLSDTAFsYSGNWRAMLGVLALPAVLLIILVVFLP 199
Cdd:cd17379 120 RRTVGIVYQMFFTLGLLI--LPGIAY-FIPHWRWLQLAVTLPNFLFLLYYWFIP 170
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
69-192 |
2.60e-04 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 43.22 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 69 MLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRgK 148
Cdd:cd17445 46 ILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQR-L 124
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 446178582 149 MISMYQLMVTLGIVLAFLSdTAFSySGNWRAMLGVLALPAVLLI 192
Cdd:cd17445 125 LVAMAGGLTMVGGHFLLLG-LALG-CGSWRVLQGTITAPLSLFL 166
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
71-197 |
3.30e-04 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 42.99 E-value: 3.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 71 GAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMi 150
Cdd:PRK03699 54 GILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLMFSHSLALFSIAMFVLGVVSGITMSIGTFLITHVYEGKQRGSR- 132
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 446178582 151 smyqLMVT------LGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVF 197
Cdd:PRK03699 133 ----LLFTdsffsmAGMIFPIIAAYLLARSIEWYWVYACIGLVYVAIFILTLF 181
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
77-129 |
3.38e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 42.97 E-value: 3.38e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 446178582 77 LFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIA 129
Cdd:PRK11652 61 LFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVG 113
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
70-198 |
4.55e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.20 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 70 LGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKM 149
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAA 317
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446178582 150 ISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFL 198
Cdd:cd17489 318 NGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
69-341 |
5.38e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.21 E-value: 5.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 69 MLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEML-IAARVVLGIAVGIAsYTAPLYLSEMASENVRG 147
Cdd:cd17353 48 IVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLfLGYGVLGGIGAGIG-YITPVSTAVKWFPDKRG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 148 kMISMyqlMVTLG-----IVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLR 222
Cdd:cd17353 127 -LATG---IVIAGfglgsLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 223 DTSekareelneIRESLKLKQgGWALFkinrnvrravflgmLLQAMQQFTGMNIIMYYAPRIFKMAGFTTteqqMIATLV 302
Cdd:cd17353 203 DYT---------PREMLRTPT-FWLLW--------------LMFFLNATAGLMLIGQAKPIGQEFAGLDA----GIAALA 254
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 446178582 303 VGLTFMFATF---IAVFTVDKAGRKPALKIGFSVMALGTLVL 341
Cdd:cd17353 255 VSILSIFNGGgrpFWGWLSDKIGRKNTLSIAFLIQGVAMFLL 296
|
|
| MFS_SLC22A4_5_OCTN1_2 |
cd17376 |
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ... |
66-199 |
6.93e-04 |
|
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 41.68 E-value: 6.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 66 SSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAvGIASYTAPLYL-SEMASEN 144
Cdd:cd17376 42 SLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMG-QISNYVVAFVLgTEILGKS 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446178582 145 VRgkmISMYQLMVTLGIVLAFLSDTAFSYS-GNWRAMLGVLALPAVLLIILVVFLP 199
Cdd:cd17376 121 VR---ILFSTLGVCIFYAIGYMLLPLFAYFiRDWRMLLLALTLPGVLCVPLWWFIP 173
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
64-197 |
7.12e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.74 E-value: 7.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 64 VVSSMMLGAAIGALFN---GWLSFRLGRKYSLMAGAILFVLGSIG--SAFATSVEMLIAARVVLGIAVGIASYTAPL--Y 136
Cdd:cd17369 266 VLLAVLIASVVAAITIplfGWLSDRVGRRPVYLAGALLAALFAFPffWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQaaF 345
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446178582 137 LSEMASENVRGKMISM-YQLMVTL-GIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVF 197
Cdd:cd17369 346 LAELFPTRVRYTGASLgYQLGAILgGGFAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
30-198 |
7.81e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 41.91 E-value: 7.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 30 AVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAF- 108
Cdd:pfam13347 230 LASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLl 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 109 -ATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASEN-------VRGKMISMYQLM----VTLGIVLAFLSDTAFSY--- 173
Cdd:pfam13347 310 gPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGelrtgkrREGTFFAMWSFIsklaTGVGLGVSGLLLSAFGYnag 389
|
170 180 190
....*....|....*....|....*....|.
gi 446178582 174 ------SGNWRAMLGVLALPAVLLIILVVFL 198
Cdd:pfam13347 390 dsvqspQAVTAIRLLYAVLPAVLFLVALLLL 420
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
29-191 |
1.27e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.07 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 29 AAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLG---RKYSLMAGAILFVLGSIG 105
Cdd:cd17475 204 AIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALLV 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 106 SAFAT-SVEMLIAARVVLGIAVGIASYTAP--LYLSEMASENVRGKMISMYQLMVTLGIVLA-----FLSDTAFSYSGNW 177
Cdd:cd17475 284 LSLLSpGTPLWLLVLLLILLGLFAIGWNGLylTLVAESAGPEQAGTALGLANTINFIGIAIGpplfgLLVDATHSYAPAW 363
|
170
....*....|....
gi 446178582 178 RAMLGVLALPAVLL 191
Cdd:cd17475 364 LALALLLVLAALLL 377
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
67-199 |
1.33e-03 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 41.11 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 67 SMMLGAAIGALFN----------GWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLy 136
Cdd:cd17389 62 SVLFGGLIGSLFSllqflsspitGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAI- 140
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 137 LSEMASENVRGKMISMYQLMVTLGIVL-----AFLSDTAFSYSGNWRAMLGVLAL--PAVLLIILVVFLP 199
Cdd:cd17389 141 VADVTSPKKRSKGMALIGVAFSLGFIIgpmigAYFASFTRSLGEVFFSMPALFALvlALADLLFIFFFLP 210
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
63-124 |
1.95e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 40.48 E-value: 1.95e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446178582 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGI 124
Cdd:PRK14995 45 WIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAI 106
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
14-165 |
2.39e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.25 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 14 SLRDTRRMNMFVSVAAAvagLLFGLDIGVIAGALPFI----TDHFVLTSRLQEWVV-SSMMLGAAIGALFNGWLSFRLGR 88
Cdd:cd17504 170 DLRLLRRRNVLLANITA---LLAGFGMFMVFQLLPQLlqlpTPTGFGLGITEAGLLlLPGALVMLIAGPLAGRLIARVGP 246
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446178582 89 KYSLMAGAILFVLGSIGSAF-ATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAF 165
Cdd:cd17504 247 RRVLLIGLVISAVGLLLLALlHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGP 324
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
60-442 |
3.31e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 39.73 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 60 LQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGS--AFATSVEMLIAARVVLGIAVGIASYTAPLYL 137
Cdd:TIGR00894 77 LQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIpwAAGGGIALVVFCRVIQGLAQGSVSPATHKII 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 138 SEMASENVRGKMISMYQLMVTLG-IVLAFLSDTAFSYSGNWRAMLGVLAL-PAVLLIILVVFLPNSPRwLAEKGRHIEAE 215
Cdd:TIGR00894 157 VKWAPPKERSRLLGMSTSGFQLGtFIFLPISGWLCESWGGWPMIFYVFGIvGCAWSLLWFVFPADDPS-IHPCISKFEKK 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 216 EVLRMLRDTSEKAREEL--NEIRESLKLkqggWALfkinrnvrravflgmLLQAMQQFTGMNIIMYYAPRIFK-MAGFTT 292
Cdd:TIGR00894 236 YINSSLQGQKGSTRQSLpiKAIPKSLPV----WAI---------------WFAIFGHFWLYTILPTYLPTFISwVLRVSG 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 293 TEQQMIATLVVGLTFMFATFIAVFT-VDKAGR----KPALKIGFSVMALGTLVLGYCLMqfdngTASSGLSWLsvgMTMM 367
Cdd:TIGR00894 297 KENGLLSSLPYLFAWLCSIFAGYLAdFLKSSKtlslTAARKIFNGIGGLGPGIFAYALP-----YLSAAFYLT---IIIL 368
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446178582 368 CIAGyAMSAAPV--VWILCSEIQPlkcRDFGIT--CSTTTNWVSNMIIGaTFLTLLDSIGAAGTfWLYTALNIAFVGIT 442
Cdd:TIGR00894 369 TLAN-AVSSGPLagVLINSLDLAP---RFLGFIkgITGLPGFIGGLIAS-TLAGNILSQDSKNV-WLIVFLIMAFVNIL 441
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
68-204 |
3.49e-03 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 39.52 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 68 MMLGAAIGALfnGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVemlIAARVVlgiavgiasytaplYLSEMASENVRG 147
Cdd:cd17484 70 LILAGALGAL--SWLALALVSNSSLALALLLLLLASLGVAFSDVV---IDALVV--------------EASRGAPQSLAG 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 446178582 148 KMISMYQLMVTLG-IVLAFLSDTAFSYSGNwRAMLGVLALPAVLLIILVVFLPNSPRW 204
Cdd:cd17484 131 DLQSLCWGSSAIGgIVGSYFSGYLLELLGP-RTVFAVTSFFPLLLLIVAFFVKEERVP 187
|
|
| PRK03633 |
PRK03633 |
putative MFS family transporter protein; Provisional |
34-222 |
4.43e-03 |
|
putative MFS family transporter protein; Provisional
Pssm-ID: 179614 [Multi-domain] Cd Length: 381 Bit Score: 39.25 E-value: 4.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 34 LLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVE 113
Cdd:PRK03633 16 LLLTLAIAVLNTLVPLWLAQEHLPTWQVGVVSSSYFTGNLVGTLLAGYVIKRIGFNRSYYLASLIFAAGCAGLGLMVGFW 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 114 MLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSysgnwRAMLGVlaLPAVLLII 193
Cdd:PRK03633 96 SWLAWRFVAGIGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYLGTVLGQLLVSKVS-----TELMSV--LPWVTGLV 168
|
170 180 190
....*....|....*....|....*....|
gi 446178582 194 LVVFLPNS-PRWLAEKGRHIEAEEVLRMLR 222
Cdd:PRK03633 169 LAAILPLLfTRILNQQAENHDSTSIWPMLK 198
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
32-197 |
4.98e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.17 E-value: 4.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 32 AGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATS 111
Cdd:cd17476 6 AQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 112 VEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMI-SMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVL 190
Cdd:cd17476 86 FIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVfSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAI 165
|
....*..
gi 446178582 191 LIILVVF 197
Cdd:cd17476 166 VAVAAIF 172
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
5-129 |
8.11e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 8.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 5 NTESALTPRSLRDTRRMNMFVsVAAAVAGLLFgldIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSF 84
Cdd:cd06179 248 TKDGLLPPRLLFRGRNFALIL-IVAFVEGMIF---YSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLT 323
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 446178582 85 RLGR-KYSLMAGAILFVLGSIGSAFAT--SVEMLIAARVVLGIAVGIA 129
Cdd:cd06179 324 KIKHiKWQLVAGFVLFTAFLALLALITpdNKALAIAFSVLAGIGIGGP 371
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
63-199 |
9.62e-03 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 38.16 E-value: 9.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446178582 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMAS 142
Cdd:cd17410 38 LLTVLPVLCMGLVALLGPWLARRVGERRGVALSLLAIAAACLWRLWSGTGPTLIASALLGGLGIAIIQALVPGLIKRRFP 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446178582 143 ENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLP 199
Cdd:cd17410 118 ARVPLAMGLYSASLMAGGGLAASLSPRLAQHSAGWQLGLGIWAVPALVALVLWWRQP 174
|
|
| |
