NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446179221|ref|WP_000257076|]
View 

MULTISPECIES: class I SAM-dependent methyltransferase [Streptococcus]

Protein Classification

class I SAM-dependent DNA methyltransferase( domain architecture ID 11471966)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047
PubMed:  23180741|12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
2-141 1.20e-28

Predicted methyltransferase, contains TPR repeat [General function prediction only];


:

Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 106.62  E-value: 1.20e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   2 ATYETFAAVYDA-VMDDTLYDKWTDFS----LRHFPKGKKKLLELACGTGIQSVRFSQAGYAVTGLDLSGDMLKLAKKRA 76
Cdd:COG4976    9 ALFDQYADSYDAaLVEDLGYEAPALLAeellARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKG 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446179221  77 TsahqSIQFIEGNMLDLSNV-GKYDLITCySDSICYMQDeveVGDVFIEVYKALEENGVFIFDVHS 141
Cdd:COG4976   89 V----YDRLLVADLADLAEPdGRFDLIVA-ADVLTYLGD---LAAVFAGVARALKPGGLFIFSVED 146
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
2-141 1.20e-28

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 106.62  E-value: 1.20e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   2 ATYETFAAVYDA-VMDDTLYDKWTDFS----LRHFPKGKKKLLELACGTGIQSVRFSQAGYAVTGLDLSGDMLKLAKKRA 76
Cdd:COG4976    9 ALFDQYADSYDAaLVEDLGYEAPALLAeellARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKG 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446179221  77 TsahqSIQFIEGNMLDLSNV-GKYDLITCySDSICYMQDeveVGDVFIEVYKALEENGVFIFDVHS 141
Cdd:COG4976   89 V----YDRLLVADLADLAEPdGRFDLIVA-ADVLTYLGD---LAAVFAGVARALKPGGLFIFSVED 146
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 39-133 2.55e-19

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 79.92  E-value: 2.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   39 LELACGTGIQSVRFSQA-GYAVTGLDLSGDMLKLAKKRATSAHQSIQFIEGNMLDLSNV-GKYDLITCySDSICYMQDEv 116
Cdd:pfam13649   2 LDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPdGSFDLVVS-SGVLHHLPDP- 79

                          90
                  ....*....|....*..
gi 446179221  117 EVGDVFIEVYKALEENG 133
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 37-139 2.24e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.28  E-value: 2.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221  37 KLLELACGTGIQSVRFSQAGYA-VTGLDLSGDMLKLAKKRATSA-HQSIQFIEGNMLDLS--NVGKYDLITCySDSICYM 112
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGArVTGVDISPVALELARKAAAALlADNVEVLKGDAEELPpeADESFDVIIS-DPPLHHL 79

                         90       100
                 ....*....|....*....|....*..
gi 446179221 113 QDEVEvgDVFIEVYKALEENGVFIFDV 139
Cdd:cd02440   80 VEDLA--RFLEEARRLLKPGGVLVLTL 104
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 8-93 2.28e-10

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 58.63  E-value: 2.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   8 AAVYDaVMDDTL----YDKWTDFSLRH-FPKGKKKLLELACGTGIQSVRFSQAGYA---VTGLDLSGDMLKLAKKRATSA 79
Cdd:PRK00216  21 APKYD-LMNDLLsfglHRVWRRKTIKWlGVRPGDKVLDLACGTGDLAIALAKAVGKtgeVVGLDFSEGMLAVGREKLRDL 99

                         90
                 ....*....|....*.
gi 446179221  80 HQS--IQFIEGNMLDL 93
Cdd:PRK00216 100 GLSgnVEFVQGDAEAL 115
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
2-141 1.20e-28

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 106.62  E-value: 1.20e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   2 ATYETFAAVYDA-VMDDTLYDKWTDFS----LRHFPKGKKKLLELACGTGIQSVRFSQAGYAVTGLDLSGDMLKLAKKRA 76
Cdd:COG4976    9 ALFDQYADSYDAaLVEDLGYEAPALLAeellARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKG 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446179221  77 TsahqSIQFIEGNMLDLSNV-GKYDLITCySDSICYMQDeveVGDVFIEVYKALEENGVFIFDVHS 141
Cdd:COG4976   89 V----YDRLLVADLADLAEPdGRFDLIVA-ADVLTYLGD---LAAVFAGVARALKPGGLFIFSVED 146
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 15-139 4.87e-23

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 90.46  E-value: 4.87e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221  15 MDDTLYDKWTDFSL-----RHFPKGKKkLLELACGTGIQSVRFSQAGYAVTGLDLSGDMLKLAKKRAtsAHQSIQFIEGN 89
Cdd:COG2227    1 MSDPDARDFWDRRLaallaRLLPAGGR-VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERA--AELNVDFVQGD 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446179221  90 MLDLS-NVGKYDLITCySDSICYMQDeveVGDVFIEVYKALEENGVFIFDV 139
Cdd:COG2227   78 LEDLPlEDGSFDLVIC-SEVLEHLPD---PAALLRELARLLKPGGLLLLST 124
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 4-141 2.62e-20

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 83.89  E-value: 2.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   4 YETFAAVYDAvmDDTLYDKWTdfslrhfPKGKKKLLELACGTGIQSVRFSQAGYAVTGLDLSGDMLKLAKKRATSAHQSI 83
Cdd:COG2226    1 FDRVAARYDG--REALLAALG-------LRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNV 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221  84 QFIEGNM--LDLSNvGKYDLITCySDSICYMQDEVEvgdVFIEVYKALEENGVFIFDVHS 141
Cdd:COG2226   72 EFVVGDAedLPFPD-GSFDLVIS-SFVLHHLPDPER---ALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 39-133 2.55e-19

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 79.92  E-value: 2.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   39 LELACGTGIQSVRFSQA-GYAVTGLDLSGDMLKLAKKRATSAHQSIQFIEGNMLDLSNV-GKYDLITCySDSICYMQDEv 116
Cdd:pfam13649   2 LDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPdGSFDLVVS-SGVLHHLPDP- 79

                          90
                  ....*....|....*..
gi 446179221  117 EVGDVFIEVYKALEENG 133
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 28-142 3.78e-16

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 74.18  E-value: 3.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221  28 LRHFPKGKKkLLELACGTGIQSVRFSQA-GYAVTGLDLSGDMLKLAKKRATSAHQS-IQFIEGNMLDL--SNVGKYDLIT 103
Cdd:COG0500   21 LERLPKGGR-VLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALARARAAKAGLGnVEFLVADLAELdpLPAESFDLVV 99

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446179221 104 CySDSICYMqDEVEVGDVFIEVYKALEENGVFIFDVHST 142
Cdd:COG0500  100 A-FGVLHHL-PPEEREALLRELARALKPGGVLLLSASDA 136
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
39-139 6.10e-15

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 68.31  E-value: 6.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221  39 LELACGTGIQSVRFSQA--GYAVTGLDLSGDMLKLAKKRatsaHQSIQFIEGNMLDLSNVGKYDLITCySDSICYMQDev 116
Cdd:COG4106    6 LDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARAR----LPNVRFVVADLRDLDPPEPFDLVVS-NAALHWLPD-- 78

                         90       100
                 ....*....|....*....|...
gi 446179221 117 eVGDVFIEVYKALEENGVFIFDV 139
Cdd:COG4106   79 -HAALLARLAAALAPGGVLAVQV 100
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 39-137 5.03e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 65.76  E-value: 5.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   39 LELACGTGIQSVRFSQAGYAVTGLDLSGDMLKLAKKRATSAHqsIQFIEGNMLDLS-NVGKYDLITCySDSICYMQDeve 117
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREG--LTFVVGDAEDLPfPDNSFDLVLS-SEVLHHVED--- 74

                          90       100
                  ....*....|....*....|
gi 446179221  118 VGDVFIEVYKALEENGVFIF 137
Cdd:pfam08241  75 PERALREIARVLKPGGILII 94
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 37-137 2.67e-12

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 62.64  E-value: 2.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221  37 KLLELACGTGIQSVRFSQA-GYAVTGLDLSGDMLKLAKKRATSA--HQSIQFIEGNMLDLSNVGKYDLITCySDSICYMQ 113
Cdd:COG2230   54 RVLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYARERAAEAglADRVEVRLADYRDLPADGQFDAIVS-IGMFEHVG 132

                         90       100
                 ....*....|....*....|....
gi 446179221 114 DEvEVGDVFIEVYKALEENGVFIF 137
Cdd:COG2230  133 PE-NYPAYFAKVARLLKPGGRLLL 155
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 37-139 2.24e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.28  E-value: 2.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221  37 KLLELACGTGIQSVRFSQAGYA-VTGLDLSGDMLKLAKKRATSA-HQSIQFIEGNMLDLS--NVGKYDLITCySDSICYM 112
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGArVTGVDISPVALELARKAAAALlADNVEVLKGDAEELPpeADESFDVIIS-DPPLHHL 79

                         90       100
                 ....*....|....*....|....*..
gi 446179221 113 QDEVEvgDVFIEVYKALEENGVFIFDV 139
Cdd:cd02440   80 VEDLA--RFLEEARRLLKPGGVLVLTL 104
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 8-93 2.28e-10

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 58.63  E-value: 2.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   8 AAVYDaVMDDTL----YDKWTDFSLRH-FPKGKKKLLELACGTGIQSVRFSQAGYA---VTGLDLSGDMLKLAKKRATSA 79
Cdd:PRK00216  21 APKYD-LMNDLLsfglHRVWRRKTIKWlGVRPGDKVLDLACGTGDLAIALAKAVGKtgeVVGLDFSEGMLAVGREKLRDL 99

                         90
                 ....*....|....*.
gi 446179221  80 HQS--IQFIEGNMLDL 93
Cdd:PRK00216 100 GLSgnVEFVQGDAEAL 115
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 39-135 1.59e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 50.83  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   39 LELACGTG--IQSVRFSQAGYAVTGLDLSGDMLKLAKKR-ATSAHQSIQFIEGNMLDLSNV--GKYDLITCySDSICYMQ 113
Cdd:pfam08242   1 LEIGCGTGtlLRALLEALPGLEYTGLDISPAALEAARERlAALGLLNAVRVELFQLDLGELdpGSFDVVVA-SNVLHHLA 79

                          90       100
                  ....*....|....*....|..
gi 446179221  114 DeveVGDVFIEVYKALEENGVF 135
Cdd:pfam08242  80 D---PRAVLRNIRRLLKPGGVL 98
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 32-117 1.28e-07

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 50.61  E-value: 1.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221  32 PKGKKkLLELACGTGIQSVRFSQAGYAVTGLDLSGDMLKLAKKRATSAH--QSIQFIEGnmlDLSNV-GKYDLITCYsDS 108
Cdd:PRK07580  62 LTGLR-ILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAGlaGNITFEVG---DLESLlGRFDTVVCL-DV 136

                         90
                 ....*....|
gi 446179221 109 -ICYMQDEVE 117
Cdd:PRK07580 137 lIHYPQEDAA 146
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 22-140 2.67e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 48.96  E-value: 2.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   22 KWTDFSLRHFPKGK--KKLLELACGTGIQSVRFSQAGYAVTGLDLSGDMLKLAKKratsahQSIQFIEGNMLDLSNVGKY 99
Cdd:pfam13489   8 LLADLLLRLLPKLPspGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALL------NVRFDQFDEQEAAVPAGKF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446179221  100 DLITCySDSICYMQDeveVGDVFIEVYKALEENGVFIFDVH 140
Cdd:pfam13489  82 DVIVA-REVLEHVPD---PPALLRQIAALLKPGGLLLLSTP 118
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 32-136 2.29e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 46.26  E-value: 2.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   32 PKGKKKLLELACGTGIQSVRFSQAGYA---VTGLDLSGDMLKLAKKRATSA-HQSIQFIEGNMLDLSNV---GKYDLITC 104
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPnaeVVGIDISEEAIEKARENAQKLgFDNVEFEQGDIEELPELledDKFDVVIS 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 446179221  105 ysdsICYMQDEVEVGDVFIEVYKALEENGVFI 136
Cdd:pfam13847  81 ----NCVLNHIPDPDKVLQEILRVLKPGGRLI 108
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
4-103 3.24e-06

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 46.66  E-value: 3.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221    4 YETFAAVYD---AVMDDTLYDKWTDFSLRHF-PKGKKKLLELACGTGIQSVRFSQAGYA---VTGLDLSGDMLKLAKKRA 76
Cdd:pfam01209   8 FSSVASKYDlmnDVISFGIHRLWKDFTMKCMgVKRGNKFLDVAGGTGDWTFGLSDSAGSsgkVVGLDINENMLKEGEKKA 87

                          90       100
                  ....*....|....*....|....*....
gi 446179221   77 TS-AHQSIQFIEGNMLDLSNV-GKYDLIT 103
Cdd:pfam01209  88 KEeGKYNIEFLQGNAEELPFEdDSFDIVT 116
PLN02585 PLN02585
magnesium protoporphyrin IX methyltransferase
 43-159 8.02e-06

magnesium protoporphyrin IX methyltransferase


Pssm-ID: 215319 [Multi-domain]  Cd Length: 315  Bit Score: 46.00  E-value: 8.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221  43 CGTGIQSVRFSQAGYAVTGLDLSGDMLKLAKKRATSAHQS---IQFIEGNMLDLSNV-GKYDLITCYSDSICYMQDEVev 118
Cdd:PLN02585 153 CGTGSLAIPLALEGAIVSASDISAAMVAEAERRAKEALAAlppEVLPKFEANDLESLsGKYDTVTCLDVLIHYPQDKA-- 230

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446179221 119 gDVFIEVYKALEENGVFIFDVHSTYQTD------KVFPGYS-----Y-HENAD 159
Cdd:PLN02585 231 -DGMIAHLASLAEKRLIISFAPKTLYYDilkrigELFPGPSkatraYlHAEAD 282
PRK14968 PRK14968
putative methyltransferase; Provisional
 33-103 2.92e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 43.35  E-value: 2.92e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446179221  33 KGKKKLLELACGTGIQSVRFSQAGYAVTGLDLSGDMLKLAKKRATSAH---QSIQFIEGNMLDLSNVGKYDLIT 103
Cdd:PRK14968  22 KKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNirnNGVEVIRSDLFEPFRGDKFDVIL 95
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 32-104 6.75e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 42.82  E-value: 6.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221  32 PKGKKKLLELACGTGIQSV----RFSQAgyAVTGLDLSGDMLKLAKKratSAHQS-----IQFIEGNMLDLSN---VGKY 99
Cdd:COG4123   35 VKKGGRVLDLGTGTGVIALmlaqRSPGA--RITGVEIQPEAAELARR---NVALNgledrITVIHGDLKEFAAelpPGSF 109


                 ....*
gi 446179221 100 DLITC 104
Cdd:COG4123  110 DLVVS 114
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
36-102 9.32e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 42.20  E-value: 9.32e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446179221  36 KKLLELACGTGIQSVRFSQAG-YAVTGLDLSGDMLKLAKKRATSAHQSIQFIEGNMLDLSNVGKYDLI 102
Cdd:COG2263   47 KTVLDLGCGTGMLAIGAALLGaKKVVGVDIDPEALEIARENAERLGVRVDFIRADVTRIPLGGSVDTV 114
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 21-104 1.88e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 41.04  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446179221   21 DKWTDFSLRHFPKG-KKKLLELACGTGIQSVRFSQAG--YAVTGLDLSGDMLKLAKK-RATSAHQSIQFIEGNMLDLSNV 96
Cdd:pfam05175  17 DIGSRLLLEHLPKDlSGKVLDLGCGAGVLGAALAKESpdAELTMVDINARALESAREnLAANGLENGEVVASDVYSGVED 96


                  ....*...
gi 446179221   97 GKYDLITC 104
Cdd:pfam05175  97 GKFDLIIS 104
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
23-76 5.25e-03

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 37.25  E-value: 5.25e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446179221  23 WTDFS--LRHFPKGKKKLLELACGTGIQSVRFSQAGYAVTGLDLSGDMLKLAKKRA 76
Cdd:PRK11036  31 WQDLDrlLAELPPRPLRVLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQRAKQAA 86
PRK08317 PRK08317
hypothetical protein; Provisional
 39-93 5.29e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 37.22  E-value: 5.29e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446179221  39 LELACGTG----IQSVRFSQAGYAVtGLDLSGDMLKLAKKRATSAHQSIQFIEGNMLDL 93
Cdd:PRK08317  24 LDVGCGPGndarELARRVGPEGRVV-GIDRSEAMLALAKERAAGLGPNVEFVRGDADGL 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH