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Conserved domains on  [gi|446194042|ref|WP_000271897|]
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MULTISPECIES: L-2-hydroxyglutarate oxidase [Salmonella]

Protein Classification

L-2-hydroxyglutarate oxidase( domain architecture ID 11485473)

L-2-hydroxyglutarate oxidase oxidizes L-2-hydroxyglutarate, to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
1-393 0e+00

L-2-hydroxyglutarate oxidase;


:

Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 709.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042   1 MYDFVIIGGGIIGMSTAMQLIDLYPDARIALLEKESAPACHQTGHNSGVIHAGVYYTPGSLKARFCLAGNQATKTFCDQN 80
Cdd:PRK11728   2 MYDFVIIGGGIVGLSTAMQLQERYPGARIAVLEKESGPARHQTGHNSGVIHAGVYYTPGSLKARFCRRGNEATKAFCDQH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  81 NIRYDTCGKMLVATSELEMARMRALWERTAANGLEREWLSAAELREREPNIIGLGGIFVPSSGIVSYRDVATAMANRFQA 160
Cdd:PRK11728  82 GIPYEECGKLLVATSELELERMEALYERARANGIEVERLDAEELREREPNIRGLGAIFVPSTGIVDYRAVAEAMAELIQA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 161 KGGEIIYHAEVSALTEHAAGVVIRTSQGrEIETATLIGCAGLMADRLVKMLGVEPGFIICPFRGEYFRLAPRHNRIVNHL 240
Cdd:PRK11728 162 RGGEIRLGAEVTALDEHANGVVVRTTQG-EYEARTLINCAGLMSDRLAKMAGLEPDFRIVPFRGEYYRLAPEKNQLVNHL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 241 IYPIPDPAMPFLGVHLTRMIDGSVTVGPNAVLALKREGYRKRDVSFTDTLEIFRSAGIRRVLQNHLLSGLGEMKNSLCKS 320
Cdd:PRK11728 241 IYPVPDPAFPFLGVHLTRMIDGSVTVGPNAVLAFKREGYRKRDFSLRDLLEILTYPGFWKLAQKHWRSGLGEMKNSLSKS 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446194042 321 GYLRRVQKYCPSLTVNDLQPWPAGVRAQAVSPDGKLIDDFLFVTTPRSIHTCNAPSPAATSAIPIGAHIVSKV 393
Cdd:PRK11728 321 GYLRLVQKYCPSLTLSDLQPYPAGVRAQAVSRDGKLVDDFLFVETPRSLHVCNAPSPAATSSLPIGEHIVSKV 393
 
Name Accession Description Interval E-value
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
1-393 0e+00

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 709.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042   1 MYDFVIIGGGIIGMSTAMQLIDLYPDARIALLEKESAPACHQTGHNSGVIHAGVYYTPGSLKARFCLAGNQATKTFCDQN 80
Cdd:PRK11728   2 MYDFVIIGGGIVGLSTAMQLQERYPGARIAVLEKESGPARHQTGHNSGVIHAGVYYTPGSLKARFCRRGNEATKAFCDQH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  81 NIRYDTCGKMLVATSELEMARMRALWERTAANGLEREWLSAAELREREPNIIGLGGIFVPSSGIVSYRDVATAMANRFQA 160
Cdd:PRK11728  82 GIPYEECGKLLVATSELELERMEALYERARANGIEVERLDAEELREREPNIRGLGAIFVPSTGIVDYRAVAEAMAELIQA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 161 KGGEIIYHAEVSALTEHAAGVVIRTSQGrEIETATLIGCAGLMADRLVKMLGVEPGFIICPFRGEYFRLAPRHNRIVNHL 240
Cdd:PRK11728 162 RGGEIRLGAEVTALDEHANGVVVRTTQG-EYEARTLINCAGLMSDRLAKMAGLEPDFRIVPFRGEYYRLAPEKNQLVNHL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 241 IYPIPDPAMPFLGVHLTRMIDGSVTVGPNAVLALKREGYRKRDVSFTDTLEIFRSAGIRRVLQNHLLSGLGEMKNSLCKS 320
Cdd:PRK11728 241 IYPVPDPAFPFLGVHLTRMIDGSVTVGPNAVLAFKREGYRKRDFSLRDLLEILTYPGFWKLAQKHWRSGLGEMKNSLSKS 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446194042 321 GYLRRVQKYCPSLTVNDLQPWPAGVRAQAVSPDGKLIDDFLFVTTPRSIHTCNAPSPAATSAIPIGAHIVSKV 393
Cdd:PRK11728 321 GYLRLVQKYCPSLTLSDLQPYPAGVRAQAVSRDGKLVDDFLFVETPRSLHVCNAPSPAATSSLPIGEHIVSKV 393
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
15-405 1.75e-160

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 458.46  E-value: 1.75e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  15 STAMQLIdLYPDARIALLEKESAPACHQTGHNSGVIHAGVYYTPGSLKARFCLAGNQATKTFCDQNNIRYDTCGKMLVAT 94
Cdd:COG0579   18 ALARELS-RYEDLKVLVLEKEDDVAQESSGNNSGVIHAGLYYTPGSLKARLCVEGNELFYELCRELGIPFKRCGKLVVAT 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  95 SELEMARMRALWERTAANGLER-EWLSAAELREREPNI--IGLGGIFVPSSGIVSYRDVATAMANRFQAKGGEIIYHAEV 171
Cdd:COG0579   97 GEEEVAFLEKLYERGKANGVPGlEILDREELRELEPLLsdEGVAALYSPSTGIVDPGALTRALAENAEANGVELLLNTEV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 172 SALTEHAAGVVIRTSQGrEIETATLIGCAGLMADRLVKMLGVEPGFIICPFRGEYFRLAPRHNrIVNHLIYPIPDPAMPF 251
Cdd:COG0579  177 TGIEREGDGWEVTTNGG-TIRARFVINAAGLYADRLAQMAGIGKDFGIFPVKGEYLVLDKPAE-LVNAKVYPVPDPGAPF 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 252 LGVHLTRMIDGSVTVGPNAVLALKREGyrkrdvSFTDTLEIFRSAGIRRVLQNHLLSGLGEMKNSLCKSGYLRRVQKYCP 331
Cdd:COG0579  255 LGVHLTRTIDGNLLFGPNAVFVPKKED------SLLDLFESLRFPNFWPMLAKNLLTKYLESVTSLSKEAFLEALRKYVP 328

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446194042 332 SLTVNDLQPWPAGVRAQAVSPDGklidDFLFVTT--PRSIHTCNAPSPAATSAIPIGAHIVSKVQA-LRASQSNPGR 405
Cdd:COG0579  329 ELPDEDLIPAFAGIRAQIIKPDG----DFVIEEAddPGSIHVLGIESPGATSALAIAEHVAELLPEkLEEKDWQPKR 401
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 15-390 1.06e-46

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 163.72  E-value: 1.06e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042   15 STAMQLIDLypDARIALLEKESAPACHQTGHNSGVIHAGVYYTPGSLKARFCLAGNQATKTFCDQNNIR--YDTCGKMLV 92
Cdd:pfam01266  13 STAYELARR--GLSVTLLERGDDPGSGASGRNAGLIHPGLRYLEPSELARLALEALDLWEELEEELGIDcgFRRCGVLVL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042   93 ATSElEMARMRALWERTAANGLEREWLSAAELREREPNIIGL-GGIFVPSSGIVSYRDVATAMANRFQAKGGEIIYHAEV 171
Cdd:pfam01266  91 ARDE-EEEALEKLLAALRRLGVPAELLDAEELRELEPLLPGLrGGLFYPDGGHVDPARLLRALARAAEALGVRIIEGTEV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  172 SALTEHAAGVVIRTsqgrEIETATLIGCAGLMADrLVKMLGVEPgfIICPFRGEYFRLAPRHNrivNHLIYPIPDPAMPF 251
Cdd:pfam01266 170 TGIEEEGGVWGVVT----TGEADAVVNAAGAWAD-LLALPGLRL--PVRPVRGQVLVLEPLPE---ALLILPVPITVDPG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  252 LGVHLTRMIDGSVTVGPnavlalkregyrkrdvsfTDTLEIFRSAGIRRVLQNHLlsglgemknslcksgyLRRVQKYCP 331
Cdd:pfam01266 240 RGVYLRPRADGRLLLGG------------------TDEEDGFDDPTPDPEEIEEL----------------LEAARRLFP 285

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446194042  332 SLtVNDLQPWpAGVRAqavSPDGKLIDDFLfvTTPRSIHTCNAPSPAATSAIPIGAHIV 390
Cdd:pfam01266 286 AL-ADIERAW-AGLRP---LPDGLPIIGRP--GSPGLYLATGHGGHGLTLAPGIGKLLA 337
thiamin_ThiO TIGR02352
glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine ...
 82-242 1.57e-11

glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 274092 [Multi-domain]  Cd Length: 337  Bit Score: 65.08  E-value: 1.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042   82 IRYDTCGKMLVATSELEMARMRALWERTAANGLEREWLSAAELREREPNIIG--LGGIFVPSSGIVSYRDVATAMANRFQ 159
Cdd:TIGR02352  69 TGYHQCGTLVVAFDEDDVEHLRQLADLQSATGMEVEWLSGRALRRLEPYLSGgiRGAVFYPDDAHVDPRALLKALEKALE 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  160 AKGGEIIYHAEVSALT---EHAAGVVirTSQGrEIETATLIGCAGLMADRLVkmlgvepGFIICPFRGEYFRL----APR 232
Cdd:TIGR02352 149 KLGVEIIEHTEVQHIEirgEKVTAIV--TPSG-DVQADQVVLAAGAWAGELL-------PLPLRPVRGQPLRLeapaVPL 218

                         170
                  ....*....|
gi 446194042  233 HNRIVNHLIY 242
Cdd:TIGR02352 219 LNRPLRAVVY 228
 
Name Accession Description Interval E-value
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
1-393 0e+00

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 709.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042   1 MYDFVIIGGGIIGMSTAMQLIDLYPDARIALLEKESAPACHQTGHNSGVIHAGVYYTPGSLKARFCLAGNQATKTFCDQN 80
Cdd:PRK11728   2 MYDFVIIGGGIVGLSTAMQLQERYPGARIAVLEKESGPARHQTGHNSGVIHAGVYYTPGSLKARFCRRGNEATKAFCDQH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  81 NIRYDTCGKMLVATSELEMARMRALWERTAANGLEREWLSAAELREREPNIIGLGGIFVPSSGIVSYRDVATAMANRFQA 160
Cdd:PRK11728  82 GIPYEECGKLLVATSELELERMEALYERARANGIEVERLDAEELREREPNIRGLGAIFVPSTGIVDYRAVAEAMAELIQA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 161 KGGEIIYHAEVSALTEHAAGVVIRTSQGrEIETATLIGCAGLMADRLVKMLGVEPGFIICPFRGEYFRLAPRHNRIVNHL 240
Cdd:PRK11728 162 RGGEIRLGAEVTALDEHANGVVVRTTQG-EYEARTLINCAGLMSDRLAKMAGLEPDFRIVPFRGEYYRLAPEKNQLVNHL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 241 IYPIPDPAMPFLGVHLTRMIDGSVTVGPNAVLALKREGYRKRDVSFTDTLEIFRSAGIRRVLQNHLLSGLGEMKNSLCKS 320
Cdd:PRK11728 241 IYPVPDPAFPFLGVHLTRMIDGSVTVGPNAVLAFKREGYRKRDFSLRDLLEILTYPGFWKLAQKHWRSGLGEMKNSLSKS 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446194042 321 GYLRRVQKYCPSLTVNDLQPWPAGVRAQAVSPDGKLIDDFLFVTTPRSIHTCNAPSPAATSAIPIGAHIVSKV 393
Cdd:PRK11728 321 GYLRLVQKYCPSLTLSDLQPYPAGVRAQAVSRDGKLVDDFLFVETPRSLHVCNAPSPAATSSLPIGEHIVSKV 393
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
15-405 1.75e-160

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 458.46  E-value: 1.75e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  15 STAMQLIdLYPDARIALLEKESAPACHQTGHNSGVIHAGVYYTPGSLKARFCLAGNQATKTFCDQNNIRYDTCGKMLVAT 94
Cdd:COG0579   18 ALARELS-RYEDLKVLVLEKEDDVAQESSGNNSGVIHAGLYYTPGSLKARLCVEGNELFYELCRELGIPFKRCGKLVVAT 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  95 SELEMARMRALWERTAANGLER-EWLSAAELREREPNI--IGLGGIFVPSSGIVSYRDVATAMANRFQAKGGEIIYHAEV 171
Cdd:COG0579   97 GEEEVAFLEKLYERGKANGVPGlEILDREELRELEPLLsdEGVAALYSPSTGIVDPGALTRALAENAEANGVELLLNTEV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 172 SALTEHAAGVVIRTSQGrEIETATLIGCAGLMADRLVKMLGVEPGFIICPFRGEYFRLAPRHNrIVNHLIYPIPDPAMPF 251
Cdd:COG0579  177 TGIEREGDGWEVTTNGG-TIRARFVINAAGLYADRLAQMAGIGKDFGIFPVKGEYLVLDKPAE-LVNAKVYPVPDPGAPF 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 252 LGVHLTRMIDGSVTVGPNAVLALKREGyrkrdvSFTDTLEIFRSAGIRRVLQNHLLSGLGEMKNSLCKSGYLRRVQKYCP 331
Cdd:COG0579  255 LGVHLTRTIDGNLLFGPNAVFVPKKED------SLLDLFESLRFPNFWPMLAKNLLTKYLESVTSLSKEAFLEALRKYVP 328

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446194042 332 SLTVNDLQPWPAGVRAQAVSPDGklidDFLFVTT--PRSIHTCNAPSPAATSAIPIGAHIVSKVQA-LRASQSNPGR 405
Cdd:COG0579  329 ELPDEDLIPAFAGIRAQIIKPDG----DFVIEEAddPGSIHVLGIESPGATSALAIAEHVAELLPEkLEEKDWQPKR 401
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 15-390 1.06e-46

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 163.72  E-value: 1.06e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042   15 STAMQLIDLypDARIALLEKESAPACHQTGHNSGVIHAGVYYTPGSLKARFCLAGNQATKTFCDQNNIR--YDTCGKMLV 92
Cdd:pfam01266  13 STAYELARR--GLSVTLLERGDDPGSGASGRNAGLIHPGLRYLEPSELARLALEALDLWEELEEELGIDcgFRRCGVLVL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042   93 ATSElEMARMRALWERTAANGLEREWLSAAELREREPNIIGL-GGIFVPSSGIVSYRDVATAMANRFQAKGGEIIYHAEV 171
Cdd:pfam01266  91 ARDE-EEEALEKLLAALRRLGVPAELLDAEELRELEPLLPGLrGGLFYPDGGHVDPARLLRALARAAEALGVRIIEGTEV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  172 SALTEHAAGVVIRTsqgrEIETATLIGCAGLMADrLVKMLGVEPgfIICPFRGEYFRLAPRHNrivNHLIYPIPDPAMPF 251
Cdd:pfam01266 170 TGIEEEGGVWGVVT----TGEADAVVNAAGAWAD-LLALPGLRL--PVRPVRGQVLVLEPLPE---ALLILPVPITVDPG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  252 LGVHLTRMIDGSVTVGPnavlalkregyrkrdvsfTDTLEIFRSAGIRRVLQNHLlsglgemknslcksgyLRRVQKYCP 331
Cdd:pfam01266 240 RGVYLRPRADGRLLLGG------------------TDEEDGFDDPTPDPEEIEEL----------------LEAARRLFP 285

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446194042  332 SLtVNDLQPWpAGVRAqavSPDGKLIDDFLfvTTPRSIHTCNAPSPAATSAIPIGAHIV 390
Cdd:pfam01266 286 AL-ADIERAW-AGLRP---LPDGLPIIGRP--GSPGLYLATGHGGHGLTLAPGIGKLLA 337
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
14-267 1.54e-32

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 126.17  E-value: 1.54e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  14 MSTAMQLIDLypDARIALLEKEsAPACHQTGHNSGVIHAGvYYTPGSLK-ARFCLAGNQATKTFCDQNNIRYD--TCGKM 90
Cdd:COG0665   15 LSTAYHLARR--GLDVTVLERG-RPGSGASGRNAGQLRPG-LAALADRAlVRLAREALDLWRELAAELGIDCDfrRTGVL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  91 LVATSELEMARMRALWERTAANGLEREWLSAAELREREPNIIG---LGGIFVPSSGIVSYRDVATAMANRFQAKGGEIIY 167
Cdd:COG0665   91 YLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSpdyAGGLYDPDDGHVDPAKLVRALARAARAAGVRIRE 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 168 HAEVSALTEHAAGVV-IRTSQGReIETATLIGCAGLMADRLVKMLGVEPGfiICPFRGEYFRLAPRHNRIVNHLIYPipd 246
Cdd:COG0665  171 GTPVTGLEREGGRVTgVRTERGT-VRADAVVLAAGAWSARLLPMLGLRLP--LRPVRGYVLVTEPLPDLPLRPVLDD--- 244

                        250       260
                 ....*....|....*....|.
gi 446194042 247 pampfLGVHLTRMIDGSVTVG 267
Cdd:COG0665  245 -----TGVYLRPTADGRLLVG 260
thiamin_ThiO TIGR02352
glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine ...
 82-242 1.57e-11

glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 274092 [Multi-domain]  Cd Length: 337  Bit Score: 65.08  E-value: 1.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042   82 IRYDTCGKMLVATSELEMARMRALWERTAANGLEREWLSAAELREREPNIIG--LGGIFVPSSGIVSYRDVATAMANRFQ 159
Cdd:TIGR02352  69 TGYHQCGTLVVAFDEDDVEHLRQLADLQSATGMEVEWLSGRALRRLEPYLSGgiRGAVFYPDDAHVDPRALLKALEKALE 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  160 AKGGEIIYHAEVSALT---EHAAGVVirTSQGrEIETATLIGCAGLMADRLVkmlgvepGFIICPFRGEYFRL----APR 232
Cdd:TIGR02352 149 KLGVEIIEHTEVQHIEirgEKVTAIV--TPSG-DVQADQVVLAAGAWAGELL-------PLPLRPVRGQPLRLeapaVPL 218

                         170
                  ....*....|
gi 446194042  233 HNRIVNHLIY 242
Cdd:TIGR02352 219 LNRPLRAVVY 228
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 13-208 6.12e-08

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 54.85  E-value: 6.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  13 GMSTAMQLIDLypDARIALLEKESAPACHQTGHnsgviHAGVYYT----PGSLKARFCLAGNQATKTFCDQN-----NIR 83
Cdd:PRK01747 272 GAALALALARR--GWQVTLYEADEAPAQGASGN-----RQGALYPllskDDNALSRFFRAAFLFARRFYDALpaagvAFD 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  84 YDTCGKMLVATSELEMARMRALWERTAANGLEReWLSAAELREREPNIIGLGGIFVPSSGIVSYRDVATAMANRFQAkGG 163
Cdd:PRK01747 345 HDWCGVLQLAWDEKSAEKIAKMLALGLPAELAR-ALDAEEAEELAGLPVPCGGIFYPQGGWLCPAELCRALLALAGQ-QL 422

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446194042 164 EIIYHAEVSALTEHAAGVVIRTSQGREIETATLIGCAGLMADRLV 208
Cdd:PRK01747 423 TIHFGHEVARLEREDDGWQLDFAGGTLASAPVVVLANGHDAARFA 467
solA PRK11259
N-methyl-L-tryptophan oxidase;
113-212 1.68e-07

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 52.92  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 113 GLEREWLSAAELREREPNI------IGL----GGIFVPSSGIVSYRDVAtamanrfQAKGGEIIYHAEVSALTEHAAGVV 182
Cdd:PRK11259 111 GLPHEVLDAAEIRRRFPQFrlpdgyIALfepdGGFLRPELAIKAHLRLA-------REAGAELLFNEPVTAIEADGDGVT 183

                         90       100       110
                 ....*....|....*....|....*....|
gi 446194042 183 IRTSQGrEIETATLIGCAGLMADRLVKMLG 212
Cdd:PRK11259 184 VTTADG-TYEAKKLVVSAGAWVKDLLPPLE 212
PRK12409 PRK12409
D-amino acid dehydrogenase small subunit; Provisional
 110-212 9.57e-07

D-amino acid dehydrogenase small subunit; Provisional


Pssm-ID: 237093 [Multi-domain]  Cd Length: 410  Bit Score: 50.79  E-value: 9.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 110 AANGLEREWLSAAELREREPNIIG--LGGIFVPSSGIVSYRDVATAMANRFQAKGGEIIYHAEVSALTEHAAGVVIRTSQ 187
Cdd:PRK12409 157 AEGGLERRAVTPEEMRAIEPTLTGeyYGGYYTPSDSTGDIHKFTTGLAAACARLGVQFRYGQEVTSIKTDGGGVVLTVQP 236

                         90       100       110
                 ....*....|....*....|....*....|
gi 446194042 188 GREIETATLIG-----CAGLMADRLVKMLG 212
Cdd:PRK12409 237 SAEHPSRTLEFdgvvvCAGVGSRALAAMLG 266
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 97-265 3.12e-06

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 48.78  E-value: 3.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  97 LEMARMRALWERTAANGLE-REWLSAAELREREPNIIGLGGIFVPSSGIVSYRDVATAMANRFQAKGGEIIYHAEVSALT 175
Cdd:COG0654   52 LELLRRLGLWDRLLARGAPiRGIRVRDGSDGRVLARFDAAETGLPAGLVVPRADLERALLEAARALGVELRFGTEVTGLE 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 176 EHAAGVVIRTSQGREIETATLIGCAGL------MADRLVKMLGVEPGFIICPFRGEYFRLAPRHNRIVNHLIYPIPDPAM 249
Cdd:COG0654  132 QDADGVTVTLADGRTLRADLVVGADGArsavrrLLGIGFTGRDYPQRALWAGVRTELRARLAAAGPRLGELLELSPRSAF 211

                        170
                 ....*....|....*.
gi 446194042 250 PFLGVHLTRMIDGSVT 265
Cdd:COG0654  212 PLRRRRAERWRRGRVV 227
PTZ00383 PTZ00383
malate:quinone oxidoreductase; Provisional
 28-383 5.30e-06

malate:quinone oxidoreductase; Provisional


Pssm-ID: 240393 [Multi-domain]  Cd Length: 497  Bit Score: 48.58  E-value: 5.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  28 RIALLEKESAPA--CHQTGHNSGVIHAGVYYTPGSL-KARFC-----LAGNQATKTFCDQNNIRYDTCGKMLVATSELEM 99
Cdd:PTZ00383  72 KIALIERRSDFAlvASHGKNNSQTIHCGDIETNYTLeKARKVkrqadMLRNYLTKLPPSERDSIIFKMQKMVLGVGEKEC 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 100 ARMRALWERTAANGLEREWLSAAELREREPNII----------GLGGIFVPS--SGI------VSYRDVATAMANrFQAK 161
Cdd:PTZ00383 152 EFLEKRYPVFKELFPSMQLLDKKEIHRVEPRVVlknnhtlreePLAALYVPNelTTVdyqklsESFVKHARRDAL-VPGK 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 162 GGEIIYHAEVSAlTEHAAGVVIRTSQGREIETAT-LIGCAGLMADRLVKMLGVEPGFIICPFRGEYFrLAPRhnrIVNHL 240
Cdd:PTZ00383 231 KISINLNTEVLN-IERSNDSLYKIHTNRGEIRARfVVVSACGYSLLFAQKMGYGLEYSCLPVAGSFY-FSGN---ILNGK 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 241 IYPIPDPAMPFLGVHLTRMI--DGSVTVGPNAVLALKREGYRKRdvSFTDTLEIFR---------------SAGIRRVLQ 303
Cdd:PTZ00383 306 VYTVQNPALPFAAVHGDPDIiaKGKTRFGPTALPLPLLERYNMS--SLPDFLKVWNpdlnllavyfdlfkdSTMRKYVLR 383

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 304 NHL--LSGLGEMKnslcksgYLRRVQKYCPSLTVNDLQPWPA--GVRAQAVSPDG-KLIDDFLFVTTPRSIHTCNAPSPA 378
Cdd:PTZ00383 384 NFLfeVPLLNKYL-------FLKDARKIVPSLTRKDLRYCVGygGVRPQLIDKVSkKLLLGEGKIDPGKGIIFNITPSPG 456


                 ....*
gi 446194042 379 ATSAI 383
Cdd:PTZ00383 457 ATTCL 461
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
116-236 4.51e-04

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 42.04  E-value: 4.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042 116 REWLSAAELREREPNII---GLGGIFvPSSGivsyRDVATAMANRFQAKGGEIIYHAEVSALTEHAagvvIRTSQGREIE 192
Cdd:COG1252  173 RKLLRYPGIDPDKVRITlveAGPRIL-PGLG----EKLSEAAEKELEKRGVEVHTGTRVTEVDADG----VTLEDGEEIP 243

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446194042 193 TATLIGCAGLMADRLVKMLGVEP---GFIICpfrGEYFRLaPRHNRI 236
Cdd:COG1252  244 ADTVIWAAGVKAPPLLADLGLPTdrrGRVLV---DPTLQV-PGHPNV 286
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
153-216 1.86e-03

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 39.95  E-value: 1.86e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446194042 153 AMANRFQAKGGEIIYHAEVSALTEHAAGVVIRTSQGREIETATLIGCAGlMADRLVKMLGVEPG 216
Cdd:COG0644   91 WLAEQAEEAGAEVRTGTRVTDVLRDDGRVVVRTGDGEEIRADYVVDADG-ARSLLARKLGLKRR 153
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 113-214 3.81e-03

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 39.43  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194042  113 GLEREWLSAAELREREPNII---GLGGIFVPSSGIVsYRDVATAMANRFQAKGGEIIYHAEVSALTEHAAGVVIRTSQGR 189
Cdd:TIGR01377 107 GLEHELLSSKQLKQRFPNIRvprNEVGLLDPNGGVL-YAEKALRALQELAEAHGATVRDGTKVVEIEPTELLVTVKTTKG 185

                          90       100
                  ....*....|....*....|....*
gi 446194042  190 EIETATLIGCAGLMADRLVKMLGVE 214
Cdd:TIGR01377 186 SYQANKLVVTAGAWTSKLLSPLGIE 210
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 150-192 9.40e-03

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 38.29  E-value: 9.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 446194042 150 VATAMANRFQAKGGEIIYHAEVSA-LTEHAAGVVIRTSQGREIE 192
Cdd:COG1233  224 LADALARLAEELGGEIRTGAEVERiLVEGGRATGVRLADGEEIR 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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