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Conserved domains on  [gi|446196739|ref|WP_000274594|]
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MULTISPECIES: AraC family transcriptional regulator [Salmonella]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 11454547)

helix-turn-helix (HTH) transcriptional regulator containing an AraC family DNA-binding HTH domain controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.1310
Gene Ontology:  GO:0003700|GO:0043565|GO:0006355
PubMed:  9409145|8831795|15808743|2644244
SCOP:  4000332

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
185-268 1.11e-28

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 104.94  E-value: 1.11e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739   185 PLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFRKNTERSP 264
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 446196739   265 SEYR 268
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
18-274 4.13e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 95.23  E-value: 4.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739  18 PLRQIYFASASGPAPELAYQVDFPRLEIVLEGELTDMSITAPLIPCDVLYVPAGGWNIPQWQTPVTTLSILFGKQQLGFS 97
Cdd:COG2207    1 LRLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739  98 VVHWDGQQHQNLTKQHVARRGPRIGSFLLQTLNEMQMQPQEQQTARLIVASLLSHCRDLLGSQIQTASRSRALFEAIREY 177
Cdd:COG2207   81 LLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 178 IDERYAAPLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFR 257
Cdd:COG2207  161 LLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFK 240

                        250
                 ....*....|....*..
gi 446196739 258 KNTERSPSEYRRQYHSQ 274
Cdd:COG2207  241 KRFGVTPSEYRKRLRAR 257
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
185-268 1.11e-28

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 104.94  E-value: 1.11e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739   185 PLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFRKNTERSP 264
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 446196739   265 SEYR 268
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
18-274 4.13e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 95.23  E-value: 4.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739  18 PLRQIYFASASGPAPELAYQVDFPRLEIVLEGELTDMSITAPLIPCDVLYVPAGGWNIPQWQTPVTTLSILFGKQQLGFS 97
Cdd:COG2207    1 LRLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739  98 VVHWDGQQHQNLTKQHVARRGPRIGSFLLQTLNEMQMQPQEQQTARLIVASLLSHCRDLLGSQIQTASRSRALFEAIREY 177
Cdd:COG2207   81 LLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 178 IDERYAAPLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFR 257
Cdd:COG2207  161 LLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFK 240

                        250
                 ....*....|....*..
gi 446196739 258 KNTERSPSEYRRQYHSQ 274
Cdd:COG2207  241 KRFGVTPSEYRKRLRAR 257
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 146-274 6.88e-21

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 90.22  E-value: 6.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 146 VASLLSHCRDLLGSQIQTASRSRAL------FEAIREYIDERYAAPLTRESVAEAFYISPNYLSHLFQK-TGaIGFNEYL 218
Cdd:COG4977  181 VARRLVVDPRRPGGQAQFSPLLVPLghrdprLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAaTG-TTPARYL 259

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446196739 219 NHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFRKNTERSPSEYRRQYHSQ 274
Cdd:COG4977  260 QRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRAR 315
HTH_18 pfam12833
Helix-turn-helix domain;
191-270 1.38e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 83.41  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739  191 VAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGY-DLKVKEVAHRCGFVDSNYFCRLFRKNTERSPSEYRR 269
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 446196739  270 Q 270
Cdd:pfam12833  81 R 81
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
183-271 2.85e-13

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 68.39  E-value: 2.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 183 AAPLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFRKNTER 262
Cdd:PRK13501 190 GAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGM 269


                 ....*....
gi 446196739 263 SPSEYRRQY 271
Cdd:PRK13501 270 TPRDYRQRF 278
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
185-268 1.11e-28

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 104.94  E-value: 1.11e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739   185 PLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFRKNTERSP 264
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 446196739   265 SEYR 268
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
18-274 4.13e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 95.23  E-value: 4.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739  18 PLRQIYFASASGPAPELAYQVDFPRLEIVLEGELTDMSITAPLIPCDVLYVPAGGWNIPQWQTPVTTLSILFGKQQLGFS 97
Cdd:COG2207    1 LRLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739  98 VVHWDGQQHQNLTKQHVARRGPRIGSFLLQTLNEMQMQPQEQQTARLIVASLLSHCRDLLGSQIQTASRSRALFEAIREY 177
Cdd:COG2207   81 LLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 178 IDERYAAPLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFR 257
Cdd:COG2207  161 LLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFK 240

                        250
                 ....*....|....*..
gi 446196739 258 KNTERSPSEYRRQYHSQ 274
Cdd:COG2207  241 KRFGVTPSEYRKRLRAR 257
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 146-274 6.88e-21

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 90.22  E-value: 6.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 146 VASLLSHCRDLLGSQIQTASRSRAL------FEAIREYIDERYAAPLTRESVAEAFYISPNYLSHLFQK-TGaIGFNEYL 218
Cdd:COG4977  181 VARRLVVDPRRPGGQAQFSPLLVPLghrdprLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAaTG-TTPARYL 259

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446196739 219 NHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFRKNTERSPSEYRRQYHSQ 274
Cdd:COG4977  260 QRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRAR 315
HTH_18 pfam12833
Helix-turn-helix domain;
191-270 1.38e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 83.41  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739  191 VAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGY-DLKVKEVAHRCGFVDSNYFCRLFRKNTERSPSEYRR 269
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 446196739  270 Q 270
Cdd:pfam12833  81 R 81
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 153-270 5.49e-15

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 73.93  E-value: 5.49e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 153 CRDLLGSQiqtASRSRALFEAIREYIDERYAAPLTRESVAEAFYISPNYLSHLFQK-TGaIGFNEYLNHTRLEHAKTLLK 231
Cdd:COG2169   71 CRPDLAPG---SPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAhTG-VTPKAYARARRLLRARQLLQ 146

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446196739 232 GyDLKVKEVAHRCGFVDSNYFCRLFRKNTERSPSEYRRQ 270
Cdd:COG2169  147 T-GLSVTDAAYAAGFGSLSRFYEAFKKLLGMTPSAYRRG 184
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
183-271 2.85e-13

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 68.39  E-value: 2.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 183 AAPLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFRKNTER 262
Cdd:PRK13501 190 GAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGM 269


                 ....*....
gi 446196739 263 SPSEYRRQY 271
Cdd:PRK13501 270 TPRDYRQRF 278
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
160-271 1.09e-12

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 66.54  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 160 QIQTASRSRALFEAIRE---YIDERYAAPLTRESVAEAFYISPNYLSHLF-QKTGaIGFNEYLNHTRLEHAKTLLKGYDL 235
Cdd:PRK10572 171 EAIPESLHPPMDPRVREacqYISDHLASEFDIESVAQHVCLSPSRLAHLFrQQLG-ISVLRWREDQRISRAKLLLQTTRM 249

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446196739 236 KVKEVAHRCGFVDSNYFCRLFRKNTERSPSEYRRQY 271
Cdd:PRK10572 250 PIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRARC 285
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
158-275 3.51e-12

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 65.08  E-value: 3.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 158 GSQIQTASRSRALFEAIREYIDERYAAPLTRESVAEAFYISPNYL-SHLFQKTGAIGFNeYLNHTRLEHAKTLLKGYDLK 236
Cdd:PRK13503 160 SSLQENGENSDARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLhRQLKQQTGLTPQR-YLNRLRLLKARHLLRHSDAS 238

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446196739 237 VKEVAHRCGFVDSNYFCRLFRKNTERSPSEYRRQYHSQL 275
Cdd:PRK13503 239 VTDIAYRCGFGDSNHFSTLFRREFSWSPRDIRQGRDGFL 277
PRK10371 PRK10371
transcriptional regulator MelR;
176-283 4.39e-11

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 62.14  E-value: 4.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 176 EYIDERYAAPLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRL 255
Cdd:PRK10371 198 GFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYST 277

                         90       100
                 ....*....|....*....|....*...
gi 446196739 256 FRKNTERSPSEYRRqyhSQLTEKQITPG 283
Cdd:PRK10371 278 FGKYVGMSPQQYRK---LSQQRRQTFPG 302
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
183-268 1.27e-10

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 60.84  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 183 AAPLTRESVAEAF----YISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFRK 258
Cdd:PRK13502 186 ANSLECPFALDAFcqqeQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTR 265

                         90
                 ....*....|
gi 446196739 259 NTERSPSEYR 268
Cdd:PRK13502 266 ETGMTPSQWR 275
ftrA PRK09393
transcriptional activator FtrA; Provisional
 143-271 3.29e-09

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 56.51  E-value: 3.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 143 RLIVASllsHcRDllGSQIQTASRSRALFEAIR-----EYIDERYAAPLTRESVAEAFYISPNYLSHLFQKTGAIGFNEY 217
Cdd:PRK09393 193 RLVVPP---H-RD--GGQAQFVPRPVASRESDRlgpliDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEW 266

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446196739 218 LNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFRKNTERSPSEYRRQY 271
Cdd:PRK09393 267 LLRERLARARDLLESSALSIDQIAERAGFGSEESLRHHFRRRAATSPAAYRKRF 320
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
165-268 5.81e-09

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 55.88  E-value: 5.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 165 SRSRALFEAIREYIDERYAAPLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRC 244
Cdd:PRK13500 202 TSSETLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTEC 281

                         90       100
                 ....*....|....*....|....
gi 446196739 245 GFVDSNYFCRLFRKNTERSPSEYR 268
Cdd:PRK13500 282 GFEDSNYFSVVFTRETGMTPSQWR 305
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 164-271 2.17e-08

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 54.27  E-value: 2.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 164 ASRSRALFEAIREYIDERYAAP-LTRESVAEAFYISPNYLSHLFQKTGAIgFNEYLNHTRLEHAKTLLKGY--DLKVKEV 240
Cdd:PRK09685 192 QPRRERQFQKVVALIDQSIQEEiLRPEWIAGELGISVRSLYRLFAEQGLV-VAQYIRNRRLDRCADDLRPAadDEKITSI 270

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446196739 241 AHRCGFVDSNYFCRLFRKNTERSPSEYRRQY 271
Cdd:PRK09685 271 AYKWGFSDSSHFSTAFKQRFGVSPGEYRRKF 301
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 174-274 4.08e-08

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 53.17  E-value: 4.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 174 IREYIDERYAAPLTRESVAEAFYISPNYLSHLFQKTGAIgFNEYLNHTRLEHAKTLLKgYDLKVKEVAHRCGFVDSNYFC 253
Cdd:PRK09940 139 VRNIVNMKLAHPWKLKDICDCLYISESLLKKKLKQEQTT-FSQILLDARMQHAKNLIR-VEGSVNKIAEQCGYASTSYFI 216

                         90       100
                 ....*....|....*....|.
gi 446196739 254 RLFRKNTERSPSEYRRQYHSQ 274
Cdd:PRK09940 217 YAFRKHFGNSPKRVSKEYRCQ 237
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
170-270 2.04e-07

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 48.38  E-value: 2.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 170 LFEAIREYIDERYAAPLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDS 249
Cdd:PRK10219   6 IIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQ 85

                         90       100
                 ....*....|....*....|.
gi 446196739 250 NYFCRLFRKNTERSPSEYRRQ 270
Cdd:PRK10219  86 QTFSRVFRRQFDRTPSDYRHR 106
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 234-269 3.01e-07

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 45.99  E-value: 3.01e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 446196739  234 DLKVKEVAHRCGFvDSNYFCRLFRKNTERSPSEYRR 269
Cdd:pfam00165   8 NLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 178-272 2.68e-06

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 47.61  E-value: 2.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 178 IDERYAAPLTRESVAEAFYISPNYLSHLFQKTGAiGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFR 257
Cdd:PRK09978 151 INNNIAHEWTLARIASELLMSPSLLKKKLREEET-SYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFR 229

                         90
                 ....*....|....*..
gi 446196739 258 KNTERSPSEY--RRQYH 272
Cdd:PRK09978 230 NYYGMTPTEYqeRSAQG 246
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 187-267 7.59e-05

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 43.52  E-value: 7.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 187 TRESVAEAFYISPNYLSHLFQKTGAiGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYFCRLFRKNTERSPSE 266
Cdd:PRK15186 199 ALKDISDSLYMSCSTLKRKLKQENT-SFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSE 277


                 .
gi 446196739 267 Y 267
Cdd:PRK15186 278 F 278
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
173-268 2.18e-04

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 40.47  E-value: 2.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446196739 173 AIREYIDERYAAPLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHRCGFVDSNYF 252
Cdd:PRK11511  13 SILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTL 92

                         90
                 ....*....|....*.
gi 446196739 253 CRLFRKNTERSPSEYR 268
Cdd:PRK11511  93 TRTFKNYFDVPPHKYR 108
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 178-219 3.83e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 34.44  E-value: 3.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 446196739  178 IDERYAAPLTRESVAEAFYISPNYLSHLFQKTGAIGFNEYLN 219
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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