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Conserved domains on  [gi|446203862|ref|WP_000281717|]
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MULTISPECIES: class I adenylate cyclase [Salmonella]

Protein Classification

class I adenylate cyclase( domain architecture ID 11459653)

class I adenylate cyclase catalyzes the conversion of ATP to cyclic AMP and pyrophosphate

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
CyaA COG3072
Adenylate cyclase, class I [Signal transduction mechanisms];
1-833 0e+00

Adenylate cyclase, class I [Signal transduction mechanisms];


:

Pssm-ID: 442306  Cd Length: 930  Bit Score: 1489.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862   1 MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPSGICFYTPDETQRHYLNELelY 80
Cdd:COG3072    7 MRKDLKTLRQRFLALNQLRLERALSAMSSRQQQVLDLLPLLFHYNHPLLPGYVSGDVPAGIANFTPDKRQLQALQRL--A 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  81 RGMTPQDPPKGELPITGVYTMGSTSSVGQSCSSDLDIWVCHQSWLDGEERQLLQRKCSLLESWAASLGVEVSFFLIDENR 160
Cdd:COG3072   85 RSFDYKQRAQHEPPILGLYLMGSTGSIAQSESSDLDIWVCHDPDLDAEARALLQQKCELIEQWAASLGVEVHFFLMDENR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 161 FRHNESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILWSMVPCDEEEHYDDYVMTLYAQGVLTPNEWLDLGGLSSLSA 240
Cdd:COG3072  165 FRHGERESLSGENCGSAQHLLLLDEFYRTAILLAGKRPLWWLVPPEEEHNYDEYVQTLLAKGFINPDEWLDFGGLGTIPA 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 241 EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNPRLLAKDIKQRLHDGEIVSFGLDPYCMMLERVTEYLTAIEDPT 320
Cdd:COG3072  245 EEYFGAGLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLEFKQAVYAGELDLDELDPYVMMLRRVTRYLLERNDLK 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 321 RLDLVRRCFYLKVCEKLSRE--RACVGWRREVLSQLVSEWGWDDARLTMLDNRANWKIDQVREAHNELLDAMMQSYRNLI 398
Cdd:COG3072  325 RLELVRRCFYLKVNEKLSRPprERSKSWRRELLERLVREWGWSEERLALLDNRAQWKIEQVREERNELVDELMQSYRNLI 404
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 399 RFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIHVPPGRANRSGWYLYNRAPNMDSIIS 478
Cdd:COG3072  405 QFARRNNISSSISPQDIGILGRKLYAAFERLPGKVTLINPGISPDLSEENLTFIQVPEGRANRAGWYLYNQSLTPADIIG 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 479 HQPLEYNRYLNKLVAWAWFNGLLTSRTHLFI-KGNGIVDLPKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVN 557
Cdd:COG3072  485 RQPLKYSRSLVELVAWCYFNGLLTASTRLHLhPGGSDLDEYELQQLVADLRQHFPVPLPAPSNEALSRPCEIRHLALFIN 564
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 558 LEYDPTAAFRNKVVHFDFRKLDVFSFGEEQNCLIGSIDLLYRNSWNEVRTLHFNGEQAMIEALKTILGKMHQDAAPPDSV 637
Cdd:COG3072  565 LGVDPTAHLSRRGIHFDSSRSDALSFGGARENLVGSIDLVYRNSWNEVRTLHFEGDDALLDALKTLLGKMHQDAAPPPSI 644
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 638 EVFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQeTGRFKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHG 717
Cdd:COG3072  645 DVFCYSQTRRGAIANRVEQLFNECISLRLGGTRQ-PNRRYLLRVAGQYYGLFFERRGVSVQKLENAVDLYRALSENKLSY 723
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 718 LSVQVE---TNQVKLPSVVDGFANEGIIQFFFEETGDekGFNIYILDESNRAEVYHHCEGSKEELVRDVSRFYSSSHDRF 794
Cdd:COG3072  724 SPLVLDrhaLEDHPLPPVIDSFASEGLIQFFFEDNGD--GFNIYILDENNSLEIYRQCEGDKEELLRPLNRFYRSSQDRR 801
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|
gi 446203862 795 TYGSSFINFNLPQFYQIVKTD-GRAQVIPFRTQPINTVPP 833
Cdd:COG3072  802 TYGSSFINFNLPQFYQIVRNDgGELQVEPFRSPLAASDAN 841
 
Name Accession Description Interval E-value
CyaA COG3072
Adenylate cyclase, class I [Signal transduction mechanisms];
1-833 0e+00

Adenylate cyclase, class I [Signal transduction mechanisms];


Pssm-ID: 442306  Cd Length: 930  Bit Score: 1489.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862   1 MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPSGICFYTPDETQRHYLNELelY 80
Cdd:COG3072    7 MRKDLKTLRQRFLALNQLRLERALSAMSSRQQQVLDLLPLLFHYNHPLLPGYVSGDVPAGIANFTPDKRQLQALQRL--A 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  81 RGMTPQDPPKGELPITGVYTMGSTSSVGQSCSSDLDIWVCHQSWLDGEERQLLQRKCSLLESWAASLGVEVSFFLIDENR 160
Cdd:COG3072   85 RSFDYKQRAQHEPPILGLYLMGSTGSIAQSESSDLDIWVCHDPDLDAEARALLQQKCELIEQWAASLGVEVHFFLMDENR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 161 FRHNESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILWSMVPCDEEEHYDDYVMTLYAQGVLTPNEWLDLGGLSSLSA 240
Cdd:COG3072  165 FRHGERESLSGENCGSAQHLLLLDEFYRTAILLAGKRPLWWLVPPEEEHNYDEYVQTLLAKGFINPDEWLDFGGLGTIPA 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 241 EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNPRLLAKDIKQRLHDGEIVSFGLDPYCMMLERVTEYLTAIEDPT 320
Cdd:COG3072  245 EEYFGAGLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLEFKQAVYAGELDLDELDPYVMMLRRVTRYLLERNDLK 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 321 RLDLVRRCFYLKVCEKLSRE--RACVGWRREVLSQLVSEWGWDDARLTMLDNRANWKIDQVREAHNELLDAMMQSYRNLI 398
Cdd:COG3072  325 RLELVRRCFYLKVNEKLSRPprERSKSWRRELLERLVREWGWSEERLALLDNRAQWKIEQVREERNELVDELMQSYRNLI 404
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 399 RFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIHVPPGRANRSGWYLYNRAPNMDSIIS 478
Cdd:COG3072  405 QFARRNNISSSISPQDIGILGRKLYAAFERLPGKVTLINPGISPDLSEENLTFIQVPEGRANRAGWYLYNQSLTPADIIG 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 479 HQPLEYNRYLNKLVAWAWFNGLLTSRTHLFI-KGNGIVDLPKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVN 557
Cdd:COG3072  485 RQPLKYSRSLVELVAWCYFNGLLTASTRLHLhPGGSDLDEYELQQLVADLRQHFPVPLPAPSNEALSRPCEIRHLALFIN 564
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 558 LEYDPTAAFRNKVVHFDFRKLDVFSFGEEQNCLIGSIDLLYRNSWNEVRTLHFNGEQAMIEALKTILGKMHQDAAPPDSV 637
Cdd:COG3072  565 LGVDPTAHLSRRGIHFDSSRSDALSFGGARENLVGSIDLVYRNSWNEVRTLHFEGDDALLDALKTLLGKMHQDAAPPPSI 644
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 638 EVFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQeTGRFKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHG 717
Cdd:COG3072  645 DVFCYSQTRRGAIANRVEQLFNECISLRLGGTRQ-PNRRYLLRVAGQYYGLFFERRGVSVQKLENAVDLYRALSENKLSY 723
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 718 LSVQVE---TNQVKLPSVVDGFANEGIIQFFFEETGDekGFNIYILDESNRAEVYHHCEGSKEELVRDVSRFYSSSHDRF 794
Cdd:COG3072  724 SPLVLDrhaLEDHPLPPVIDSFASEGLIQFFFEDNGD--GFNIYILDENNSLEIYRQCEGDKEELLRPLNRFYRSSQDRR 801
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|
gi 446203862 795 TYGSSFINFNLPQFYQIVKTD-GRAQVIPFRTQPINTVPP 833
Cdd:COG3072  802 TYGSSFINFNLPQFYQIVRNDgGELQVEPFRSPLAASDAN 841
cyaA PRK09450
class I adenylate cyclase;
1-826 0e+00

class I adenylate cyclase;


Pssm-ID: 236522 [Multi-domain]  Cd Length: 830  Bit Score: 1474.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862   1 MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPSGICFYTPDETQRHYLNELELY 80
Cdd:PRK09450   1 MRKYLETLKQRLDALNQLRLARALAALSPAFQQVLSLLPLLLHVNHPLLPGYVSGNTPAGICNFTPDETQLAYLQRLELS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  81 RGMTPQDPPKGELPITGVYTMGSTSSVGQSCSSDLDIWVCHQSWLDGEERQLLQRKCSLLESWAASLGVEVSFFLIDENR 160
Cdd:PRK09450  81 FGYSVQDPPKGELPITGLYTMGSTGSIGQSESSDLDIWVCHRPWLDAEERQLLQRKCSLLEQWAASLGVEVNFFLMDEER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 161 FRHNESGS-LGGEDCGSTQHILLLDEFYRTAVRLAGKRILWSMVPCDEEEHYDDYVMTLYAQGVLTPNEWLDLGGLSSLS 239
Cdd:PRK09450 161 FRHNESGSaLGGEDCGSTQHILLLDEFYRTAIRLAGKRPLWWLVPVEEEEHYDDYVMTLYSKGFLNPNEWLDLGGLSSLP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 240 AEEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNPRLLAKDIKQRLHDGEIVSFGLDPYCMMLERVTEYLTAIEDP 319
Cdd:PRK09450 241 AEEYFGASLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLDFKQRLLAGEIDSDGLDPYCLMLERVTRYLTAINDP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 320 TRLDLVRRCFYLKVCEKLSRERACVGWRREVLSQLVSEWGWDDARLTMLDNRANWKIDQVREAHNELLDAMMQSYRNLIR 399
Cdd:PRK09450 321 TRLELVRRCFYLKVGEKLSRERACVGWRRELLSQLVSEWGWDEERLALLDNRANWKIGQVREFHNELVDALMQSYRNLIR 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 400 FARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIHVPPGRANRSGWYLYNRAPNMDSIISH 479
Cdd:PRK09450 401 FARRNNLSSSISPQDIGILTRKLYAAFERLPGKVTLLNPQISPDLSEPDLTFIEVPPGRANRSGWYLYNQAPDPDSIIGH 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 480 QPLEYNRYLNKLVAWAWFNGLLTSRTHLFIKGN-GIVDLPKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVNL 558
Cdd:PRK09450 481 QPLEYNRYLNKLVAWAYFNGLLTSSTRLHLKGNgSDLDLAKLQELVADLRQHFPLRLPAPTPQALLQPCEIRHLLIIVNL 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 559 EYDPTAAFRNKVVHFDFRKLDVFSFGEEQNCLIGSIDLLYRNSWNEVRTLHFNGEQAMIEALKTILGKMHQDAAPPDSVE 638
Cdd:PRK09450 561 EVDPTAHLRGQVVHFDFRNLDVFSFGGEQENLVGSVDLIYRNSWNEVRTLHFEGEQALLDALKTILGKMHQDAAPPPSVE 640
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 639 VFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQETGrfKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHGL 718
Cdd:PRK09450 641 VFCYSQHLRGLIRTRVQQLVSECIELRLGSTRQEPG--KALRVAGQTWGLFFERLGVSVQKLENAVEFYGALSENKLHGL 718
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 719 SVQVETNQVKLPSVVDGFANEGIIQFFFEETgdEKGFNIYILDESNRAEVYHHCEGSKEELVRDVSRFYSSSHDRFTYGS 798
Cdd:PRK09450 719 PVQLDTNFLKLPAVVDGFASEGIIQFFFEDN--EDGFNVYILDESNRLEHYHHCEGSKEELVRDVSRFYSSSHDRFTYGS 796
                        810       820
                 ....*....|....*....|....*...
gi 446203862 799 SFINFNLPQFYQIVKTDGRAQVIPFRTQ 826
Cdd:PRK09450 797 SFINFNLPQFYQLVRVDGRLQVIPFRSQ 824
Adenylate_cycl pfam01295
Adenylate cyclase, class-I;
228-826 0e+00

Adenylate cyclase, class-I;


Pssm-ID: 426186  Cd Length: 601  Bit Score: 969.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  228 EWLDLGGLSSLSAEEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNPRLLAKDIKQRLHDGEIVSFGLDPYCMMLE 307
Cdd:pfam01295   1 DWLDLGGLSALPAEEYFGASLWQLYKGIDSPYKAVLKILLLEAYSSEYPNTELLSSQFKRRLLAGDFTSYHLDPYLLMLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  308 RVTEYLTAIEDPTRLDLVRRCFYLKVCEKLSRE--RACVGWRREVLSQLVSEWGWDDARLTMLDNRANWKIDQVREAHNE 385
Cdd:pfam01295  81 RVTDYLTKINDFKRLDLVRRCFYLKAGEGLSRLqpNGAKDWRRDKLQELVQQWHWSDELIQTLDNRRHWKVGQVKWANNQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  386 LLDAMMQSYRNLIRFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIHVPPGRANRSGWY 465
Cdd:pfam01295 161 LLELLMLSYRNLIQFARKHNISESISPEDIGILTRKLYTAFEELPGKVTLLNPLISPDLSEPDLTFIEVPEGRSNKAGWY 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  466 LYNRAPNMDSIISHQPLEYNRYLNKLVAWAWFNGLLTSRTHLFIKGNGiVDLP--KLQEMVADVSHHFPLRLPAPTPKAL 543
Cdd:pfam01295 241 LYNQPPDPADLIGRRPLEYAKYLSKLVAWAYFNGLLTESTRLHLVSQG-VDLTsdKLSQFVTDLRLSFPVRAPKPTNQDL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  544 YSPCEIRHLAIIVNLEYDPTAAFRNKVVHFDFRKLDVFSFGEEQNCLIGSIDLLYRNSWNEVRTLHFNGEQAMIEALKTI 623
Cdd:pfam01295 320 SHPCEIRHLVIFINLEQDPTTHWSGQEVMVDIQNADLFSFGRSQENLVGSVDLIYRNSWNEIRTLHFEGENALLKALKTI 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  624 LGKMHQDAAPPDSVEVFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQETgRFKALRVSGQTWGLFFERLNVSVQKLENA 703
Cdd:pfam01295 400 LNKIHRDAAPPESIDVFCYSRRLRSQLRNAVKQLLNRCIELRLGTIQSRT-QVKPLRIGGKNYGLFFERRGVSVQDLENA 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  704 IEFYGAISHNKLHGLSVQV--ETNQVKLPSVVDGFANEGIIQFFFEEtgDEKGFNIYILDESNRAEVYHHCEGSKEELVR 781
Cdd:pfam01295 479 VDFYGQISRNKLVELPRPElgDDPFLHIPAIIDAFASEGLIQFFFED--NEDGFNVYILDEKNELEIYHQCDGSKDELVN 556
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 446203862  782 DVSRFYSSSHDRFTYGSSFINFNLPQFYQIVKTDGRAQVIPFRTQ 826
Cdd:pfam01295 557 EVNRFYASSESRKNTNPAFINFNLPQFYQLVRVNGELKVVPFRSS 601
 
Name Accession Description Interval E-value
CyaA COG3072
Adenylate cyclase, class I [Signal transduction mechanisms];
1-833 0e+00

Adenylate cyclase, class I [Signal transduction mechanisms];


Pssm-ID: 442306  Cd Length: 930  Bit Score: 1489.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862   1 MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPSGICFYTPDETQRHYLNELelY 80
Cdd:COG3072    7 MRKDLKTLRQRFLALNQLRLERALSAMSSRQQQVLDLLPLLFHYNHPLLPGYVSGDVPAGIANFTPDKRQLQALQRL--A 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  81 RGMTPQDPPKGELPITGVYTMGSTSSVGQSCSSDLDIWVCHQSWLDGEERQLLQRKCSLLESWAASLGVEVSFFLIDENR 160
Cdd:COG3072   85 RSFDYKQRAQHEPPILGLYLMGSTGSIAQSESSDLDIWVCHDPDLDAEARALLQQKCELIEQWAASLGVEVHFFLMDENR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 161 FRHNESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILWSMVPCDEEEHYDDYVMTLYAQGVLTPNEWLDLGGLSSLSA 240
Cdd:COG3072  165 FRHGERESLSGENCGSAQHLLLLDEFYRTAILLAGKRPLWWLVPPEEEHNYDEYVQTLLAKGFINPDEWLDFGGLGTIPA 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 241 EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNPRLLAKDIKQRLHDGEIVSFGLDPYCMMLERVTEYLTAIEDPT 320
Cdd:COG3072  245 EEYFGAGLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLEFKQAVYAGELDLDELDPYVMMLRRVTRYLLERNDLK 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 321 RLDLVRRCFYLKVCEKLSRE--RACVGWRREVLSQLVSEWGWDDARLTMLDNRANWKIDQVREAHNELLDAMMQSYRNLI 398
Cdd:COG3072  325 RLELVRRCFYLKVNEKLSRPprERSKSWRRELLERLVREWGWSEERLALLDNRAQWKIEQVREERNELVDELMQSYRNLI 404
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 399 RFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIHVPPGRANRSGWYLYNRAPNMDSIIS 478
Cdd:COG3072  405 QFARRNNISSSISPQDIGILGRKLYAAFERLPGKVTLINPGISPDLSEENLTFIQVPEGRANRAGWYLYNQSLTPADIIG 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 479 HQPLEYNRYLNKLVAWAWFNGLLTSRTHLFI-KGNGIVDLPKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVN 557
Cdd:COG3072  485 RQPLKYSRSLVELVAWCYFNGLLTASTRLHLhPGGSDLDEYELQQLVADLRQHFPVPLPAPSNEALSRPCEIRHLALFIN 564
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 558 LEYDPTAAFRNKVVHFDFRKLDVFSFGEEQNCLIGSIDLLYRNSWNEVRTLHFNGEQAMIEALKTILGKMHQDAAPPDSV 637
Cdd:COG3072  565 LGVDPTAHLSRRGIHFDSSRSDALSFGGARENLVGSIDLVYRNSWNEVRTLHFEGDDALLDALKTLLGKMHQDAAPPPSI 644
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 638 EVFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQeTGRFKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHG 717
Cdd:COG3072  645 DVFCYSQTRRGAIANRVEQLFNECISLRLGGTRQ-PNRRYLLRVAGQYYGLFFERRGVSVQKLENAVDLYRALSENKLSY 723
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 718 LSVQVE---TNQVKLPSVVDGFANEGIIQFFFEETGDekGFNIYILDESNRAEVYHHCEGSKEELVRDVSRFYSSSHDRF 794
Cdd:COG3072  724 SPLVLDrhaLEDHPLPPVIDSFASEGLIQFFFEDNGD--GFNIYILDENNSLEIYRQCEGDKEELLRPLNRFYRSSQDRR 801
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|
gi 446203862 795 TYGSSFINFNLPQFYQIVKTD-GRAQVIPFRTQPINTVPP 833
Cdd:COG3072  802 TYGSSFINFNLPQFYQIVRNDgGELQVEPFRSPLAASDAN 841
cyaA PRK09450
class I adenylate cyclase;
1-826 0e+00

class I adenylate cyclase;


Pssm-ID: 236522 [Multi-domain]  Cd Length: 830  Bit Score: 1474.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862   1 MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPSGICFYTPDETQRHYLNELELY 80
Cdd:PRK09450   1 MRKYLETLKQRLDALNQLRLARALAALSPAFQQVLSLLPLLLHVNHPLLPGYVSGNTPAGICNFTPDETQLAYLQRLELS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  81 RGMTPQDPPKGELPITGVYTMGSTSSVGQSCSSDLDIWVCHQSWLDGEERQLLQRKCSLLESWAASLGVEVSFFLIDENR 160
Cdd:PRK09450  81 FGYSVQDPPKGELPITGLYTMGSTGSIGQSESSDLDIWVCHRPWLDAEERQLLQRKCSLLEQWAASLGVEVNFFLMDEER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 161 FRHNESGS-LGGEDCGSTQHILLLDEFYRTAVRLAGKRILWSMVPCDEEEHYDDYVMTLYAQGVLTPNEWLDLGGLSSLS 239
Cdd:PRK09450 161 FRHNESGSaLGGEDCGSTQHILLLDEFYRTAIRLAGKRPLWWLVPVEEEEHYDDYVMTLYSKGFLNPNEWLDLGGLSSLP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 240 AEEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNPRLLAKDIKQRLHDGEIVSFGLDPYCMMLERVTEYLTAIEDP 319
Cdd:PRK09450 241 AEEYFGASLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLDFKQRLLAGEIDSDGLDPYCLMLERVTRYLTAINDP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 320 TRLDLVRRCFYLKVCEKLSRERACVGWRREVLSQLVSEWGWDDARLTMLDNRANWKIDQVREAHNELLDAMMQSYRNLIR 399
Cdd:PRK09450 321 TRLELVRRCFYLKVGEKLSRERACVGWRRELLSQLVSEWGWDEERLALLDNRANWKIGQVREFHNELVDALMQSYRNLIR 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 400 FARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIHVPPGRANRSGWYLYNRAPNMDSIISH 479
Cdd:PRK09450 401 FARRNNLSSSISPQDIGILTRKLYAAFERLPGKVTLLNPQISPDLSEPDLTFIEVPPGRANRSGWYLYNQAPDPDSIIGH 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 480 QPLEYNRYLNKLVAWAWFNGLLTSRTHLFIKGN-GIVDLPKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVNL 558
Cdd:PRK09450 481 QPLEYNRYLNKLVAWAYFNGLLTSSTRLHLKGNgSDLDLAKLQELVADLRQHFPLRLPAPTPQALLQPCEIRHLLIIVNL 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 559 EYDPTAAFRNKVVHFDFRKLDVFSFGEEQNCLIGSIDLLYRNSWNEVRTLHFNGEQAMIEALKTILGKMHQDAAPPDSVE 638
Cdd:PRK09450 561 EVDPTAHLRGQVVHFDFRNLDVFSFGGEQENLVGSVDLIYRNSWNEVRTLHFEGEQALLDALKTILGKMHQDAAPPPSVE 640
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 639 VFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQETGrfKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHGL 718
Cdd:PRK09450 641 VFCYSQHLRGLIRTRVQQLVSECIELRLGSTRQEPG--KALRVAGQTWGLFFERLGVSVQKLENAVEFYGALSENKLHGL 718
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862 719 SVQVETNQVKLPSVVDGFANEGIIQFFFEETgdEKGFNIYILDESNRAEVYHHCEGSKEELVRDVSRFYSSSHDRFTYGS 798
Cdd:PRK09450 719 PVQLDTNFLKLPAVVDGFASEGIIQFFFEDN--EDGFNVYILDESNRLEHYHHCEGSKEELVRDVSRFYSSSHDRFTYGS 796
                        810       820
                 ....*....|....*....|....*...
gi 446203862 799 SFINFNLPQFYQIVKTDGRAQVIPFRTQ 826
Cdd:PRK09450 797 SFINFNLPQFYQLVRVDGRLQVIPFRSQ 824
Adenylate_cycl pfam01295
Adenylate cyclase, class-I;
228-826 0e+00

Adenylate cyclase, class-I;


Pssm-ID: 426186  Cd Length: 601  Bit Score: 969.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  228 EWLDLGGLSSLSAEEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNPRLLAKDIKQRLHDGEIVSFGLDPYCMMLE 307
Cdd:pfam01295   1 DWLDLGGLSALPAEEYFGASLWQLYKGIDSPYKAVLKILLLEAYSSEYPNTELLSSQFKRRLLAGDFTSYHLDPYLLMLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  308 RVTEYLTAIEDPTRLDLVRRCFYLKVCEKLSRE--RACVGWRREVLSQLVSEWGWDDARLTMLDNRANWKIDQVREAHNE 385
Cdd:pfam01295  81 RVTDYLTKINDFKRLDLVRRCFYLKAGEGLSRLqpNGAKDWRRDKLQELVQQWHWSDELIQTLDNRRHWKVGQVKWANNQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  386 LLDAMMQSYRNLIRFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIHVPPGRANRSGWY 465
Cdd:pfam01295 161 LLELLMLSYRNLIQFARKHNISESISPEDIGILTRKLYTAFEELPGKVTLLNPLISPDLSEPDLTFIEVPEGRSNKAGWY 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  466 LYNRAPNMDSIISHQPLEYNRYLNKLVAWAWFNGLLTSRTHLFIKGNGiVDLP--KLQEMVADVSHHFPLRLPAPTPKAL 543
Cdd:pfam01295 241 LYNQPPDPADLIGRRPLEYAKYLSKLVAWAYFNGLLTESTRLHLVSQG-VDLTsdKLSQFVTDLRLSFPVRAPKPTNQDL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  544 YSPCEIRHLAIIVNLEYDPTAAFRNKVVHFDFRKLDVFSFGEEQNCLIGSIDLLYRNSWNEVRTLHFNGEQAMIEALKTI 623
Cdd:pfam01295 320 SHPCEIRHLVIFINLEQDPTTHWSGQEVMVDIQNADLFSFGRSQENLVGSVDLIYRNSWNEIRTLHFEGENALLKALKTI 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  624 LGKMHQDAAPPDSVEVFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQETgRFKALRVSGQTWGLFFERLNVSVQKLENA 703
Cdd:pfam01295 400 LNKIHRDAAPPESIDVFCYSRRLRSQLRNAVKQLLNRCIELRLGTIQSRT-QVKPLRIGGKNYGLFFERRGVSVQDLENA 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862  704 IEFYGAISHNKLHGLSVQV--ETNQVKLPSVVDGFANEGIIQFFFEEtgDEKGFNIYILDESNRAEVYHHCEGSKEELVR 781
Cdd:pfam01295 479 VDFYGQISRNKLVELPRPElgDDPFLHIPAIIDAFASEGLIQFFFED--NEDGFNVYILDEKNELEIYHQCDGSKDELVN 556
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 446203862  782 DVSRFYSSSHDRFTYGSSFINFNLPQFYQIVKTDGRAQVIPFRTQ 826
Cdd:pfam01295 557 EVNRFYASSESRKNTNPAFINFNLPQFYQLVRVNGELKVVPFRSS 601
Adenyl_cycl_N pfam12633
Adenylate cyclase NT domain;
4-200 3.55e-113

Adenylate cyclase NT domain;


Pssm-ID: 432684 [Multi-domain]  Cd Length: 198  Bit Score: 343.01  E-value: 3.55e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862    4 YIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPSGICFYTPDETQRHYLNELELYRGM 83
Cdd:pfam12633   1 DLETLRQRFDALNQLRLERALAALSPRQQQVLRLLPLLLHVNHPLLPGYVSGDTPCGIANFEPSKFQLALLDRLFRSFTY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446203862   84 TPQDPPKGELPITGVYTMGSTSSVGQSCSSDLDIWVCHQSWLDGEERQLLQRKCSLLESWAASLGVEVSFFLIDENRFRH 163
Cdd:pfam12633  81 KETKTDISDPPILGLYLMGSTGSIAQSASSDLDIWVCHRPGLDAEELELLQRKCQLIEQWAAQFGVEVHFFLMDPERFRS 160
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 446203862  164 NESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILW 200
Cdd:pfam12633 161 NRSSSLTEESSGSAQHLLLLDEFYRTAIRLAGKRPLW 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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