|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
1-466 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 824.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 1 MYQLEDDSLMLHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSIG- 79
Cdd:PRK09243 1 MLMYNDDSLALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRSLGi 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 80 YKDDFLSYLKDLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFG 159
Cdd:PRK09243 81 FDEDFLDYLRNFRFTGDVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAGGRPLLEFG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 160 TRRAQEIDAALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAER-HKNCVFLVDTFHTLKS 238
Cdd:PRK09243 161 SRRAQGPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETyPDNTVLLVDTYDTLKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 239 GVPNAIKVAKELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLI 318
Cdd:PRK09243 241 GVPNAIKVAKELGDGIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 319 TGYDQPALGAVYKLVAIENEDGsYSDRIKLSNNAEKVTTPGKKNVYRIINkKTGKAEGDYITLENENPydEQPLKLFHPV 398
Cdd:PRK09243 321 TGSDAPALGGVYKLVAIEGEGG-MIPKIKLSNSPEKVTTPGRKQVYRIYD-KGGKAEADVITLADEEE--EEPLKMFHPV 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446206576 399 HTYKMKFIKSFEAIDLHHNIYENGKLVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSKAC 466
Cdd:PRK09243 397 HTYKSKTVKNFDAEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
6-472 |
0e+00 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 646.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 6 DDSLMLHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSIG-YKDDF 84
Cdd:COG1488 1 MDNLALLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSLGvFDEDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 85 LSYLKDLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGTRRAQ 164
Cdd:COG1488 81 LDYLADFRFPGDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAGGRPLHDFGLRRAH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 165 EIDAALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERH-KNCVFLVDTFHTLkSGVPNA 243
Cdd:COG1488 161 GLEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAHDDELEAFRAFAEAYpDGTTLLVDTYDTL-SGVPNA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 244 IKVAKELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLITGYDQ 323
Cdd:COG1488 240 IELAKELLARGGLLGIRLDSGDLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 324 PALGAVYKLVAIENeDGSYSDRIKLSNNAEKVTTPGKKNVYRIinKKTGKAEGDYITLENENPyDEQPLKLFHPVhtykm 403
Cdd:COG1488 320 PTLGFVYKLVAVEG-DGEWRPVIKLSETPGKKSKPGRKQVYRR--DEDGKATADLVALEDEPL-PGEPEPLLVPV----- 390
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446206576 404 kfiksfeaidlhhniYENGKLVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSKACWDNKHK 472
Cdd:COG1488 391 ---------------FRDGKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQ 444
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
11-464 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 613.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 11 LHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSIG-YKDDFLSYLK 89
Cdd:TIGR01513 2 LLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASLGiFDDAFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 90 DLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGTRRAQEIDAA 169
Cdd:TIGR01513 82 EFRFSGTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKPLLEFGLRRAQGPDAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 170 LWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERH-KNCVFLVDTFHTLKSGVPNAIKVAK 248
Cdd:TIGR01513 162 LKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYpKATVLLVDTYDTLRSGLPNAIAVAK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 249 ELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLITGYDQPALGA 328
Cdd:TIGR01513 242 ELGEQGKVVGVRIDSGDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 329 VYKLVAIENedgsySDRIKLSNNAEKVTTPGKKNVYRIInKKTGKAEGDYITLENENPYDEQPLKLFHPVHtykmkfiks 408
Cdd:TIGR01513 322 VYKLVAYEG-----RPVMKLSENPEKSTLPGRKQVFRLY-DATGKFLGDELTLADEPIEDLNQEKCTPVFA--------- 386
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 446206576 409 fEAIDLHHNIYENGKLVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSK 464
Cdd:TIGR01513 387 -PVEPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSP 441
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
11-333 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 550.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 11 LHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSIG-YKDDFLSYLK 89
Cdd:cd01570 2 LLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGiFDEEFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 90 DLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGTRRAQEIDAA 169
Cdd:cd01570 82 GFRFTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGGRPLLEFGLRRAQGPDAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 170 LWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERH-KNCVFLVDTFHTLKSGVPNAIKVAK 248
Cdd:cd01570 162 LSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFDDELAAFRAFAEAYpDNFTLLVDTYDTLRSGLPNAIAVAK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 249 ELGDK-INFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLITGYDQPALG 327
Cdd:cd01570 242 ELGALgYRLVGVRIDSGDLAYLSKEARKMLDEAGLTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALG 321
|
....*.
gi 446206576 328 AVYKLV 333
Cdd:cd01570 322 GVYKLV 327
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
11-134 |
2.58e-45 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 154.59 E-value: 2.58e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 11 LHNDLYQINMAESYWNDNIhEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLK-SIGY-KDDFLSYL 88
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRrSLPYfKPDFLDYL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446206576 89 KDLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVN 134
Cdd:pfam17767 80 RNFRFDPSIVAVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
1-466 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 824.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 1 MYQLEDDSLMLHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSIG- 79
Cdd:PRK09243 1 MLMYNDDSLALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRSLGi 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 80 YKDDFLSYLKDLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFG 159
Cdd:PRK09243 81 FDEDFLDYLRNFRFTGDVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAGGRPLLEFG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 160 TRRAQEIDAALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAER-HKNCVFLVDTFHTLKS 238
Cdd:PRK09243 161 SRRAQGPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETyPDNTVLLVDTYDTLKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 239 GVPNAIKVAKELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLI 318
Cdd:PRK09243 241 GVPNAIKVAKELGDGIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 319 TGYDQPALGAVYKLVAIENEDGsYSDRIKLSNNAEKVTTPGKKNVYRIINkKTGKAEGDYITLENENPydEQPLKLFHPV 398
Cdd:PRK09243 321 TGSDAPALGGVYKLVAIEGEGG-MIPKIKLSNSPEKVTTPGRKQVYRIYD-KGGKAEADVITLADEEE--EEPLKMFHPV 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446206576 399 HTYKMKFIKSFEAIDLHHNIYENGKLVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSKAC 466
Cdd:PRK09243 397 HTYKSKTVKNFDAEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
6-472 |
0e+00 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 646.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 6 DDSLMLHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSIG-YKDDF 84
Cdd:COG1488 1 MDNLALLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSLGvFDEDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 85 LSYLKDLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGTRRAQ 164
Cdd:COG1488 81 LDYLADFRFPGDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAGGRPLHDFGLRRAH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 165 EIDAALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERH-KNCVFLVDTFHTLkSGVPNA 243
Cdd:COG1488 161 GLEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAHDDELEAFRAFAEAYpDGTTLLVDTYDTL-SGVPNA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 244 IKVAKELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLITGYDQ 323
Cdd:COG1488 240 IELAKELLARGGLLGIRLDSGDLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 324 PALGAVYKLVAIENeDGSYSDRIKLSNNAEKVTTPGKKNVYRIinKKTGKAEGDYITLENENPyDEQPLKLFHPVhtykm 403
Cdd:COG1488 320 PTLGFVYKLVAVEG-DGEWRPVIKLSETPGKKSKPGRKQVYRR--DEDGKATADLVALEDEPL-PGEPEPLLVPV----- 390
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446206576 404 kfiksfeaidlhhniYENGKLVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSKACWDNKHK 472
Cdd:COG1488 391 ---------------FRDGKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQ 444
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
11-464 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 613.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 11 LHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSIG-YKDDFLSYLK 89
Cdd:TIGR01513 2 LLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASLGiFDDAFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 90 DLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGTRRAQEIDAA 169
Cdd:TIGR01513 82 EFRFSGTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKPLLEFGLRRAQGPDAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 170 LWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERH-KNCVFLVDTFHTLKSGVPNAIKVAK 248
Cdd:TIGR01513 162 LKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYpKATVLLVDTYDTLRSGLPNAIAVAK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 249 ELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLITGYDQPALGA 328
Cdd:TIGR01513 242 ELGEQGKVVGVRIDSGDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 329 VYKLVAIENedgsySDRIKLSNNAEKVTTPGKKNVYRIInKKTGKAEGDYITLENENPYDEQPLKLFHPVHtykmkfiks 408
Cdd:TIGR01513 322 VYKLVAYEG-----RPVMKLSENPEKSTLPGRKQVFRLY-DATGKFLGDELTLADEPIEDLNQEKCTPVFA--------- 386
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 446206576 409 fEAIDLHHNIYENGKLVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSK 464
Cdd:TIGR01513 387 -PVEPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSP 441
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
11-333 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 550.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 11 LHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSIG-YKDDFLSYLK 89
Cdd:cd01570 2 LLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGiFDEEFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 90 DLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGTRRAQEIDAA 169
Cdd:cd01570 82 GFRFTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGGRPLLEFGLRRAQGPDAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 170 LWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERH-KNCVFLVDTFHTLKSGVPNAIKVAK 248
Cdd:cd01570 162 LSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFDDELAAFRAFAEAYpDNFTLLVDTYDTLRSGLPNAIAVAK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 249 ELGDK-INFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLITGYDQPALG 327
Cdd:cd01570 242 ELGALgYRLVGVRIDSGDLAYLSKEARKMLDEAGLTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALG 321
|
....*.
gi 446206576 328 AVYKLV 333
Cdd:cd01570 322 GVYKLV 327
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
6-472 |
5.79e-162 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 465.76 E-value: 5.79e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 6 DDSLMLHNDLYQINMAESYWNDNIHEKmAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSI-GYKDDF 84
Cdd:PRK12484 1 QRNLALLTDLYEVTMANAYLREGMSAP-ATFSLFYRKLPDGRGFLIAAGLADVVEFLEAFRFDEQDLRYLRGLnQFSEEF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 85 LSYLKDLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGTRRAQ 164
Cdd:PRK12484 80 LAWLAGLRFTGDVRAVPEGTVVFPNEPLLEVTAPLIEAQLVETFLLNQINHQSLIASKAARCVLAAAGRPVVDFGARRAH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 165 EIDAALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERH-KNCVFLVDTFHTLKsGVPNA 243
Cdd:PRK12484 160 GTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAFPDEVAAFRAFARLYpDATTLLVDTYDTLR-GVRNA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 244 IKVAKELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLITGYDQ 323
Cdd:PRK12484 239 IEVAKELGNRFDPRGVRLDSGDLAELSKATRAILDAAGLEQVKIVASGGLDEYRIAALLAAGAPIDGFGVGTRLGVAADA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 324 PALGAVYKLVAienedgsYSDRIKLSNNAEKVTTPGKKNVYRIINKKTGKaeGDYITLENENPyDEQPLKLFHPVHTykm 403
Cdd:PRK12484 319 PVLDSAYKLVA-------YEGRGVTKLSSGKVTYPGRKQVFRLYEHGTAC--GDVIGLHTENI-PDGREPLLVPVMT--- 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446206576 404 kfiksfeaidlhhniyeNGKLVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSKACWDNKHK 472
Cdd:PRK12484 386 -----------------NGRRIQHAPTLDGARDWCEAQLAALPPEARRLVDPVAVSVTLSGELARLRHA 437
|
|
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
11-484 |
1.73e-137 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 407.12 E-value: 1.73e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 11 LHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSI---GYKDDFLSY 87
Cdd:PLN02885 13 LLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVmpsGCEDAFFDY 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 88 LKDLKFTG-SIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDK-LMEFGTRRAQE 165
Cdd:PLN02885 93 LRGLDCSDvEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKvLLEFGLRRAQG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 166 IDAALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTY---------------GD------------------- 211
Cdd:PLN02885 173 PDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYmgldeivdktlrsadGSsvcedfvslvqewlsklqe 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 212 --------------EYVAFKKYAERHKNCVF-LVDTFHTLKSGVPNAIKVA---KELGDKInfVGIRLDSGDIAYLSKEA 273
Cdd:PLN02885 253 ssslrgvfsetnqsELAAFTSYALAFPNSFLaLVDTYDVMKSGIPNFCAVAlalNDLGYKA--VGIRLDSGDLAYLSLEA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 274 RRMLDE-------AGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLITGYDQPALGAVYKLVAIENEdgsysDRI 346
Cdd:PLN02885 331 RKFFRTieeelgvPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQ-----PRI 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 347 KLSNNAEKVTTPGKKNVYRIINkKTGKAEGDYITLENE-NPYDEQPLKLFHPVHTYKMKFIKSFEAIDLHHNIYE--NGK 423
Cdd:PLN02885 406 KLSEDVEKVTIPCKKRCYRLYG-KEGYPLVDLMTGENEpPPKVGERILCRHPFNESKRAYVVPQRVEELLKCYWDgsSGK 484
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446206576 424 LVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSKACWDNKHKRIFEVAEhVKEM 484
Cdd:PLN02885 485 PREELPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKLYDFIHFLWLNEAP-VGEL 544
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
11-331 |
3.77e-117 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 347.72 E-value: 3.77e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 11 LHNDLYQINMAESYWNdNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSIGYKDDFLSYLKD 90
Cdd:cd01567 2 LDTDLYKLTMMQAYLY-PYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLLIFGEFFLYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 91 L-KFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIA------------SNDKLME 157
Cdd:cd01567 81 LgKLPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAgglletkdnleeLGFKLHD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 158 FGTRRAQEIDAALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGD----EYVAFKKYAE--RHKNCVFLVD 231
Cdd:cd01567 161 FGTRRRHSPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGAleeaAFEAFARWLPqfGGGLGIALID 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 232 TFHTLKsGVPNAIKVAKELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGF--TETKIIASNDLD-EETITSLKAQGAK- 307
Cdd:cd01567 241 TYDTDN-GFLNALKLAKALGAGGGLLGVRLDSGDPVELIKKVRKHLDELGIdlNKKKIIISGDLDtEEAIELLLEQGASp 319
|
330 340
....*....|....*....|....
gi 446206576 308 VDSWGVGTKLITGYDQPALGAVYK 331
Cdd:cd01567 320 NDAFGVGTSLTNDLGRPPLGFVYK 343
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
14-331 |
2.88e-68 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 220.19 E-value: 2.88e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 14 DLYQINMAESYwndNIHEKMAVFDLYFRkmpfNSGYAVFNGLKRVIDFIEHFGFsesdleylksigykddflsylkdlKF 93
Cdd:cd00516 1 DLYKLTMIQAY---PPPDTRATAEFTAR----EDPYGVLAGLEEALELLELLRF------------------------PG 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 94 TGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIA--SNDKLMEFGTRRAQEiDAALW 171
Cdd:cd00516 50 PLVILAVPEGTVVEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAkgANTKVHDFGTRKTTP-GLRLL 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 172 GARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYgDEYVAFKKYAERH-KNCVFLVDTFHTLksgVPNAIKVAKEL 250
Cdd:cd00516 129 EKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF-GELAAVKALRRWLpELFIALIDVEVDT---LEEALEAAKAG 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 251 GdkinFVGIRLDSG-----DIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGakVDSWGVGTKLITgydQPA 325
Cdd:cd00516 205 G----ADGIRLDSGspeelDPAVLILKARAHLDGKGLPRVKIEASGGLDEENIRAYAETG--VDVFGVGTLLHS---APP 275
|
....*.
gi 446206576 326 LGAVYK 331
Cdd:cd00516 276 LDIVLK 281
|
|
| NAPRTase_B |
cd01571 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ... |
82-318 |
1.97e-46 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238805 [Multi-domain] Cd Length: 302 Bit Score: 163.60 E-value: 1.97e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 82 DDFLSYLKDLKFTgsIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGTR 161
Cdd:cd01571 42 EEVLALLEGLPVK--VYALPEGTIFNPKEPVLRIEGPYQDFGELETAILGILARASSIATNAARVKLAAGDKPVISFGDR 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 162 RAQEIDAALWGaRAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYV----AFKKYAERHKNCVFLVDTFHTLK 237
Cdd:cd01571 120 RDHPAIQPMDG-RAAYIGGCDGVSTVLGAELLGEKPSGTMPHALIQIFGGDQVeawkAFDETYPEDVPRIALIDTFNDEK 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 238 SGvpnAIKVAKELGDKINfvGIRLDS-----GDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGakVDSWG 312
Cdd:cd01571 199 EE---ALKAAKALGDKLD--GVRLDTpssrrGVFRYLIREVRWALDIRGYKHVKIFVSGGLDEEDIKELEDVG--VDAFG 271
|
....*.
gi 446206576 313 VGTKLI 318
Cdd:cd01571 272 VGTAIS 277
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
11-134 |
2.58e-45 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 154.59 E-value: 2.58e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 11 LHNDLYQINMAESYWNDNIhEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLK-SIGY-KDDFLSYL 88
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRrSLPYfKPDFLDYL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446206576 89 KDLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVN 134
Cdd:pfam17767 80 RNFRFDPSIVAVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| PRK08662 |
PRK08662 |
nicotinate phosphoribosyltransferase; Reviewed |
82-315 |
2.67e-41 |
|
nicotinate phosphoribosyltransferase; Reviewed
Pssm-ID: 236328 [Multi-domain] Cd Length: 343 Bit Score: 150.80 E-value: 2.67e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 82 DDFLSYLKDLKFTgsIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGTR 161
Cdd:PRK08662 59 EEVLELLEGKPVD--VYALPEGTLFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAGDKPVLSFGAR 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 162 R-----AQEIDaalwgaRAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERHKNCV---FLVDTF 233
Cdd:PRK08662 137 HvhpaiAPMMD------RAAYIGGCDGVSGVLGAELLGIEPSGTMPHALILIFGDQVEAWKAFDEVVPPDVpriALVDTF 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 234 htlKSGVPNAIKVAKELGDKINfvGIRLDS-----GDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQgakV 308
Cdd:PRK08662 211 ---KDEREEALRAAEALGDRLD--GVRLDTpssrrGNFRKIVREVRWTLDIRGYEHVKIFVSGGLDPERIRELRDV---V 282
|
....*..
gi 446206576 309 DSWGVGT 315
Cdd:PRK08662 283 DGFGVGT 289
|
|
| NAPRTase_C |
pfam17956 |
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ... |
360-470 |
1.05e-38 |
|
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.
Pssm-ID: 465585 [Multi-domain] Cd Length: 111 Bit Score: 136.54 E-value: 1.05e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 360 KKNVYRIINKKtGKAEGDYITLENEN-PYDEQPLKLFHPVHTYKMKFIKSFEAIDLHHNIYENGKLVYQMPTEDESREYL 438
Cdd:pfam17956 1 RKQVYRLYDKD-GKAIADLITLADEPpPDPGEEILCFHPFDEWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYV 79
|
90 100 110
....*....|....*....|....*....|..
gi 446206576 439 ALGLQSIWDENKRFLNPQEYPVDLSKACWDNK 470
Cdd:pfam17956 80 QEQLSRLWPEHKRLLNPHPYKVDLSEKLYQLK 111
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
11-356 |
8.83e-19 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 87.69 E-value: 8.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 11 LHNDLYQINMaesywndniheKMAVFDLY--------FR---KMPFNSGYAvfNGLKRVIDFIEHFGFSESDLEYLK-SI 78
Cdd:cd01401 4 LDTDLYKLTM-----------QQAVLHHYpdvqvtyeFTnrsPEDFLEEAA--EALREQIDHLANLRFSEEELAYLRrSL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 79 GY-KDDFLSYLKDLKF----TGSIRSMQEGELcfgnepLLRVEAPLIQAQLIETILLNIVN---------------FHTL 138
Cdd:cd01401 71 PFlKPDYLDYLELFRLnpeeVVVRLDTGKGQL------DIRISGPWKDTILYEVPLLAIVSevyfrfrdadwdyeeQLEK 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 139 ITTKASRIRQIA-----SNDKLMEFGTRR-----AQEIdaALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAH----A 204
Cdd:cd01401 145 LEEKLERLLEEAkrrdlNGFRFSDFGTRRrfsyeVQET--VLKGLKQAAPGYLTGTSNVHFAMKYGLTPIGTVAHewfmA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 205 FVQTYGDE----YVAFKKYAERHKN--CVFLVDTFHT---LKSGVPNAIKVakelgdkinFVGIRLDSGDIAYLSKEARR 275
Cdd:cd01401 223 HQALTGDLkdsqKAALERWVREYGGdlGIALTDTFGTdafLRDFDLYFAKL---------FDGVRHDSGDPFEWGEKAIA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 276 MLDEAGF-TETK-IIASNDLDEETITSLK---AQGAKVdSWGVGTKL-----ITGYDQPaLGAVYKLVAIEnedGSYSdr 345
Cdd:cd01401 294 HYEKLGIdPKTKtLVFSDGLDVEKALELYeyfKGRIKV-SFGIGTNLtndfgNKEKSTP-LNIVIKLVECN---GRPV-- 366
|
410
....*....|.
gi 446206576 346 IKLSNNAEKVT 356
Cdd:cd01401 367 AKISDSPGKNM 377
|
|
| PRK07188 |
PRK07188 |
nicotinate phosphoribosyltransferase; Provisional |
50-318 |
1.77e-17 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235953 [Multi-domain] Cd Length: 352 Bit Score: 83.84 E-value: 1.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 50 AVFNGLKRVIDFIEHFgfsESDLEYLKsigykddflsylkdlkftgsIRSMQEGELCFGNEPLLRVEAPLIQAQLIETIL 129
Cdd:PRK07188 50 AVLCGTDEVIALLKTF---AKDPSKLK--------------------IRYLKDGDIINPFETVLEIEGPYENFGFLEGII 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 130 LNIVNFHTLITTKASRIRQIASNDKLMEFGTRR----AQEIDAalwgaRAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAF 205
Cdd:PRK07188 107 DGILARRTSVATNAYNVVQAANEKPVIFMGDRAdhylQQAGDG-----YAAYIGGISAFSTHAQNEWWGKSGFGTMPHAL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 206 VQTY-GDEYVAFKKYAERHKN--CVFLVDtFHTlkSGVPNAIKVAKELGDKINfvGIRLD-SGDIA-------------- 267
Cdd:PRK07188 182 IQMFnGDVVEACKAYHKTFPEdeLIALVD-YNN--DVITDSLKVAREFGDKLK--GVRVDtSKNMIdkyfirhpevlgtf 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 446206576 268 -------YLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLI 318
Cdd:PRK07188 257 dprgvnpELIKALRKALDENGGKHVKIIVSSGFDAKKIREFEAQNVPVDIYGVGSSLL 314
|
|
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
8-358 |
4.84e-16 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 79.81 E-value: 4.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 8 SLmLHNDLYQINMAesywndnihekMAVFDLY--------FR---KMPFNSGYAvfNGLKRVIDFIEHFGFSESDLEYLK 76
Cdd:PRK05321 11 SL-LDTDFYKLTMQ-----------QAVLHHYpdaqveyeFIcrnDEVDLAEYI--DEIREQLDHLCTLRLTDDELDYLR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 77 SIGY-KDDFLSYLKDLKFtgsirSMQEGELCFGNEPL-LRVEAPLIQAQLIETILLNIVN---------------FHTLI 139
Cdd:PRK05321 77 GLPFfKPDFLDWLRLFRL-----NPYEVTVSIDDGQLdIRIEGPWLETILWEVPLLAIISelyfrarspevlyaqAKRRL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 140 TTKASRIRQIA--SNDKLMEFGTRR-----AQE--IDAALWGARAAYIGgfdsTSNVRAGKLFGIPVSGTHAHAFVQTY- 209
Cdd:PRK05321 152 WEKIELLKALPdlSGFKIADFGTRRrfsfeWQEevVEALKEGLPGAFVG----TSNVHLAMKLGLTPIGTMAHEWFMAHq 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 210 --GDEYVAFKKYA------ERHKNC-VFLVDTFHT---LKSgvpNAIKVAKelgdkiNFVGIRLDSGD--------IAY- 268
Cdd:PRK05321 228 alGPRLRDSQYAAledwvrEYRGDLgIALTDTIGMdafLRD---FDLYFAK------LFDGLRHDSGDpiewgekaIAHy 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 269 --LSKEARrmldeagfteTK-IIASNDLDEETITSLK---AQGAKVdSWGVGTKL---ITGYdqPALGAVYKLVAIeneD 339
Cdd:PRK05321 299 ekLGIDPR----------TKtLVFSDGLDFDKALELYrhfKGRIKL-SFGIGTNLtndFPGV--KPLNIVIKLVEC---N 362
|
410
....*....|....*....
gi 446206576 340 GSYSdrIKLSNNAEKVTTP 358
Cdd:PRK05321 363 GRPV--AKLSDSPGKTMCD 379
|
|
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
10-357 |
3.31e-13 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 70.94 E-value: 3.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 10 MLHNDLYQINMAESYWNdNIHEKMAVFDLYFR-KMPFNSGYAvfNGLKRVIDFIEHFGFSESDLEYLKS-IGY-KDDFLS 86
Cdd:TIGR01514 5 LLDTDLYKITMHQAVFH-NFPDVHVTYEFICRsSQLFLKEAA--EALREEISALGNLRFTDDEIEYLKQeLPYlKSDYID 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 87 YLKDLKFTG----SIRSMQEGELcfgnepLLRVEAPLIQAQLIETILLNIVN--FHTLIT-------------TKASRIR 147
Cdd:TIGR01514 82 YLRNFRFHPeeqvEVGIDDKGKL------DIRISGSWRDTILYEIPLLAIISelYFRFRDaeadyeqqlevleSKLDQLK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 148 QIASND-------KLMEFGTRR---AQEIDAALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYG--DEYVA 215
Cdd:TIGR01514 156 AEIAAEtmfengfRFSEFGTRRrfsLEVQDLVTQGLKQAAPSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQaiSEYRN 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 216 FKKYA-ERHKNC------VFLVDTFHT---LKS-GVPNAIKvakelgdkinFVGIRLDSGDIAYLSKEARRMLDEAGF-T 283
Cdd:TIGR01514 236 AQKVAlECWINEydgdlgIALTDTFTTdafLRDfRPPFADA----------YDGLRHDSGDPVEWGDKAIAHYQKLGIdP 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 284 ETKIIA-SNDLDEE---TITSLKAQGAKVdSWGVGTKLIT--GYDQPaLGAVYKLVAIENEDGsysdrIKLSNNAEKVTT 357
Cdd:TIGR01514 306 KSKIIIfSDSLDVEkaiELSHYFKGRVKA-SFGIGTNLTNdfGKVEP-LNIVIKLVECNGNPV-----AKLSDSPGKTMG 378
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
154-361 |
4.02e-11 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 62.78 E-value: 4.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 154 KLMEFGTRRAQEIDAALWGArAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGD---EYVAFKK-------YAERH 223
Cdd:pfam04095 2 KLHDFGTRRRSSLESQEIVG-LAHLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQEldaNLRQFQKdaldlwhAEYRG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 224 KNCVFLVDTFHT---LKSGVPNAIKVakelgdkinFVGIRLDSGD----IAYLSKEARRMLDEAGFTETkIIASNDLDEE 296
Cdd:pfam04095 81 NLGIALTDTVTMdafLKDFDLYFAKL---------YLGVRPDSGDpvewGEKLIAHYGSTLNIDGYTKR-LIFSDGLDVE 150
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 297 TITSL----KAQGAKVdSWGVGTKLITGYDQPALGAVYKLVAIENEdgsysdrIKLSN-NAEKVTTPGKK 361
Cdd:pfam04095 151 KIIELleyfKGKGFNI-AFGIGTNLTQDLNRDTLGFAVKATPLNIV-------IKLVEvNGDPVAKISDS 212
|
|
| PRK09198 |
PRK09198 |
putative nicotinate phosphoribosyltransferase; Provisional |
125-441 |
1.27e-03 |
|
putative nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 236407 [Multi-domain] Cd Length: 463 Bit Score: 41.03 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 125 IETILLNIVNFHTLITTKASRIRQI--------ASND-----KLMEFGTRRAQEIDAALWGArAAYIGGFDSTSNVRAGK 191
Cdd:PRK09198 132 LETLLLRNVWYPSTVATISWEYKQLirqylektADDLdflpfQLHDFGARGMSSLESAALGG-AAHLVSFLGTDTIPALL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 192 L-----------FGIPVSgthAHAFVQTYG--DEYVAFKKYAERHKNCVFL---VDTFHTLksgvpNAIKVA--KELGDK 253
Cdd:PRK09198 211 YaeryynadmagFSIPAT---EHSVMTSWGreGELEAYRNMIEQFYPGGIVsivSDSYDLW-----NAITEPwgGELKDE 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 254 INFVG----IRLDSGDIAYLSKEARRMLDEA-GFTETK-----------IIASNDLDEETITS----LKAQGAKVD--SW 311
Cdd:PRK09198 283 ILARGgtlvIRPDSGDPVTIICGTLELLDEIfGGTVNSkgykvlnphvgVIQGDGITLDSIEAileaLKAKGFAAEniVF 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446206576 312 GVGTKLITGYDQPALGAVYKLVAIENeDGSYSDRIKlsnnaEKVTTPGKKNvyriinkKTG-----KAEGDYITLENENP 386
Cdd:PRK09198 363 GMGGALLQYVNRDTQGFAMKASAIEV-NGEWRDIFK-----DPITDQGKKS-------KKGrlkliKDNGEYRTVDLDEA 429
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446206576 387 YDEQPlklfhpvhtykmkfiksfeaiDLHHNIYENGKLVYQMpTEDESREYLALG 441
Cdd:PRK09198 430 GDEND---------------------DLLQTVFENGKLLVEY-SLAEIRARLHAA 462
|
|
| |
