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Conserved domains on  [gi|446207165|ref|WP_000285020|]
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MULTISPECIES: NAD(P)/FAD-dependent oxidoreductase [Staphylococcus]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 12044987)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.14.13.-
Gene Ontology:  GO:0050660|GO:0050661
SCOP:  4000073

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HI0933_like pfam03486
HI0933-like protein;
2-412 0e+00

HI0933-like protein;


:

Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 588.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165    2 YQTIIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGRCNVTN-RLPYAEIIKNIPGNGKFLYSPFSIFDNE 80
Cdd:pfam03486   1 FDVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRKILISGGGRCNVTNlSEEPDNFLSRYPGNPKFLKSALSRFTPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   81 SIIDFFESRGVKLKEEDHGRMFPVSNKAQDVVDTLVTTIERQHVTIKEEEAVSRIEVNTDQTFTVHTQNNSYESHSLVIA 160
Cdd:pfam03486  81 DFIAFFESLGVPLKEEDHGRLFPDSDKASDIVDALLNELKELGVKIRLRTRVLSVEKDDDGRFRVKTGGEELEADSLVLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  161 TGGTSVPQTGSTGDGYKFAQDLGHTITELFPTEVPITSAEPFIKSNRLKGLSLKDVELSvlkkNGKKRISHQMDMLFTHF 240
Cdd:pfam03486 161 TGGLSWPKTGSTGFGYPLAEQFGHTIIPLRPALVPFTIDEPFLFLKRLSGISLKNVVLS----NGKGGITFRGELLFTHR 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  241 GISGPAALRCSQFVYKEQKNQKTQHISmaIDAFPELNHEQLKQHITSLLSDTPDKIIKNSLHGLIEERYLLFMLEQAGID 320
Cdd:pfam03486 237 GLSGPAILQLSSYWRRAILKKGGVTLS--IDLLPDLDAEELAARLEKPRGAHPKKSLKNSLAGLLPKRLAEFLLEQAGIE 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  321 ENTTSHHLSNQQLNDLVNMFKGFVFKVNGTLPIDKAFVTGGGVSLKEIQPKTMMSKLVPGLFLCGEVLDIHGYTGGYNIT 400
Cdd:pfam03486 315 PDKKLAQLSKKELAALAQLLKAWTFTPNGTEGYRTAEVTAGGVDTKELSSKTMESKKVPGLFFAGEVLDVDGWTGGYNLQ 394

                         410
                  ....*....|..
gi 446207165  401 SALVTGHVAGLY 412
Cdd:pfam03486 395 WAWSSGYAAGQG 406
 
Name Accession Description Interval E-value
HI0933_like pfam03486
HI0933-like protein;
2-412 0e+00

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 588.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165    2 YQTIIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGRCNVTN-RLPYAEIIKNIPGNGKFLYSPFSIFDNE 80
Cdd:pfam03486   1 FDVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRKILISGGGRCNVTNlSEEPDNFLSRYPGNPKFLKSALSRFTPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   81 SIIDFFESRGVKLKEEDHGRMFPVSNKAQDVVDTLVTTIERQHVTIKEEEAVSRIEVNTDQTFTVHTQNNSYESHSLVIA 160
Cdd:pfam03486  81 DFIAFFESLGVPLKEEDHGRLFPDSDKASDIVDALLNELKELGVKIRLRTRVLSVEKDDDGRFRVKTGGEELEADSLVLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  161 TGGTSVPQTGSTGDGYKFAQDLGHTITELFPTEVPITSAEPFIKSNRLKGLSLKDVELSvlkkNGKKRISHQMDMLFTHF 240
Cdd:pfam03486 161 TGGLSWPKTGSTGFGYPLAEQFGHTIIPLRPALVPFTIDEPFLFLKRLSGISLKNVVLS----NGKGGITFRGELLFTHR 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  241 GISGPAALRCSQFVYKEQKNQKTQHISmaIDAFPELNHEQLKQHITSLLSDTPDKIIKNSLHGLIEERYLLFMLEQAGID 320
Cdd:pfam03486 237 GLSGPAILQLSSYWRRAILKKGGVTLS--IDLLPDLDAEELAARLEKPRGAHPKKSLKNSLAGLLPKRLAEFLLEQAGIE 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  321 ENTTSHHLSNQQLNDLVNMFKGFVFKVNGTLPIDKAFVTGGGVSLKEIQPKTMMSKLVPGLFLCGEVLDIHGYTGGYNIT 400
Cdd:pfam03486 315 PDKKLAQLSKKELAALAQLLKAWTFTPNGTEGYRTAEVTAGGVDTKELSSKTMESKKVPGLFFAGEVLDVDGWTGGYNLQ 394

                         410
                  ....*....|..
gi 446207165  401 SALVTGHVAGLY 412
Cdd:pfam03486 395 WAWSSGYAAGQG 406
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
5-416 0e+00

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 512.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   5 IIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGRCNVTNRLPYAEIIKNIPGNGKFLYSPFSIFDNESIID 84
Cdd:COG2081    1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKVGRKILISGGGRCNFTNSEPLPEFLNYYGGNPHFLKSALSRFTPEDLIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  85 FFESRGVKLKEEDHGRMFPVSNKAQDVVDTLVTTIERQHVTIKEEEAVSRIEVnTDQTFTVHTQNN-SYESHSLVIATGG 163
Cdd:COG2081   81 FFEGLGIETKEESSGRVFPDSSKASDILRALLAELREAGVEIRLRTRVTGIEK-EDGGFGVETPDGeTVRADAVVLATGG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165 164 TSVPQTGSTGDGYKFAQDLGHTITELFPTEVPITSAEPFIKsnRLKGLSLKDVELSVlkkNGKKRISHQMDMLFTHFGIS 243
Cdd:COG2081  160 LSYPKLGSTGDGYRLAEQFGHTITPLRPALVPLTLSEHFFK--RLAGLSLKNVALSV---GGKKIASFRGELLFTHRGLS 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165 244 GPAALRCSQFVYKEQKNQKtqhISMAIDAFPELNHEQLKQHITSLLSDTPDKIIKNSLHGLIEERYLLFMLEQAgiDENT 323
Cdd:COG2081  235 GPAILQLSSYWRDALKKGG---ATLTIDLLPDLDLEELDARLARPREKNGKKSLKNVLRGLLPKRLAALLLELA--DPDK 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165 324 TSHHLSNQQLNDLVNMFKGFVFKVNGTLPIDKAFVTGGGVSLKEIQPKTMMSKLVPGLFLCGEVLDIHGYTGGYNITSAL 403
Cdd:COG2081  310 PLAQLSKKEREALAALLKAWPLTPTGTRGYDEAIVTAGGVDTKELDPKTMESKKVPGLYFAGEVLDVDGPTGGYNLQWAW 389

                        410
                 ....*....|...
gi 446207165 404 VTGHVAGLYAGHY 416
Cdd:COG2081  390 SSGYAAGQAAAAW 402
TIGR00275 TIGR00275
flavoprotein, HI0933 family; The model when searched with a partial length search brings in ...
 5-411 1.47e-179

flavoprotein, HI0933 family; The model when searched with a partial length search brings in proteins with a dinucleotide-binding motif (Rossman fold) over the initial 40 residues of the model, including oxidoreductases and dehydrogenases. Partially characterized members include an FAD-binding protein from Bacillus cereus and flavoprotein HI0933 from Haemophilus influenzae. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272992 [Multi-domain]  Cd Length: 400  Bit Score: 505.98  E-value: 1.47e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165    5 IIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGRCNVTNRLPYAEIIKNIPGNGKFLYSPFSIFDNESIID 84
Cdd:TIGR00275   1 IIIGGGAAGLMAAITAARAGLSVLLLEKNKKIGKKLLISGGGRCNLTNSCPTPEFVAYYPRNGKFLRSALSRFSNKDLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   85 FFESRGVKLKEEDHGRMFPVSNKAQDVVDTLVTTIERQHVTIKEEEAVSRIEvNTDQTFTVHTQNNSYESHSLVIATGGT 164
Cdd:TIGR00275  81 FFESLGLELKVEEDGRVFPCSDSAADVLDALLNELKELGVEILTNSKVKSIE-KEDGGFGVETSGGEYEADKVIIATGGL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  165 SVPQTGSTGDGYKFAQDLGHTITELFPTEVPITSAEPFIKsnRLKGLSLKDVELSvlKKNGKKRISHQMDMLFTHFGISG 244
Cdd:TIGR00275 160 SYPQLGSTGDGYEIAESLGHTIVPPVPALVPLTLDESFLK--ELSGISLDGVVLS--LVNGKKVLEEFGELLFTHFGLSG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  245 PAALRCSQFVYKEQKNQKTQhiSMAIDAFPELNHEQLKQHITSLLSDTPDKIIKNSLHGLIEERYLLFMLEQAGIDENTT 324
Cdd:TIGR00275 236 PAILDLSAFAARALLKHKGV--ELEIDLLPDLSEEELEQRLKRLRKSNPKKTVKNILKGLLPKRLAELLLEQLGIDPDLP 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  325 SHHLSNQQLNDLVNMFKGFVFKVNGTLPIDKAFVTGGGVSLKEIQPKTMMSKLVPGLFLCGEVLDIHGYTGGYNITSALV 404
Cdd:TIGR00275 314 AAQLSKKEIKKLVQLLKNWPFTISGTRGFKEAEVTAGGVSLKEINPKTMESKLVPGLYFAGEVLDIDGDTGGYNLQWAWS 393


                  ....*..
gi 446207165  405 TGHVAGL 411
Cdd:TIGR00275 394 SGYLAGK 400
PRK06753 PRK06753
hypothetical protein; Provisional
 5-185 2.58e-04

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 42.75  E-value: 2.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   5 IIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGRcNVTNRLPYAEIIKNIPGNGKFLySPFSIFDnesiid 84
Cdd:PRK06753   4 AIIGAGIGGLTAAALLQEQGHEVKVFEKNESVKEVGAGIGIGD-NVIKKLGNHDLAKGIKNAGQIL-STMNLLD------ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  85 ffesrgvklkeeDHGRMFpvsNKAQDVVDTLVTTIERQHV-----------TIKEEEAVSRIEVNTDQTfTVHTQNNSYE 153
Cdd:PRK06753  76 ------------DKGTLL---NKVKLKSNTLNVTLHRQTLidiiksyvkedAIFTGKEVTKIENETDKV-TIHFADGESE 139

                        170       180       190
                 ....*....|....*....|....*....|....
gi 446207165 154 SHSLVIATGG--TSVPQTGSTGDGYKFAqdlGHT 185
Cdd:PRK06753 140 AFDLCIGADGihSKVRQSVNADSKVRYQ---GYT 170
 
Name Accession Description Interval E-value
HI0933_like pfam03486
HI0933-like protein;
2-412 0e+00

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 588.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165    2 YQTIIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGRCNVTN-RLPYAEIIKNIPGNGKFLYSPFSIFDNE 80
Cdd:pfam03486   1 FDVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRKILISGGGRCNVTNlSEEPDNFLSRYPGNPKFLKSALSRFTPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   81 SIIDFFESRGVKLKEEDHGRMFPVSNKAQDVVDTLVTTIERQHVTIKEEEAVSRIEVNTDQTFTVHTQNNSYESHSLVIA 160
Cdd:pfam03486  81 DFIAFFESLGVPLKEEDHGRLFPDSDKASDIVDALLNELKELGVKIRLRTRVLSVEKDDDGRFRVKTGGEELEADSLVLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  161 TGGTSVPQTGSTGDGYKFAQDLGHTITELFPTEVPITSAEPFIKSNRLKGLSLKDVELSvlkkNGKKRISHQMDMLFTHF 240
Cdd:pfam03486 161 TGGLSWPKTGSTGFGYPLAEQFGHTIIPLRPALVPFTIDEPFLFLKRLSGISLKNVVLS----NGKGGITFRGELLFTHR 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  241 GISGPAALRCSQFVYKEQKNQKTQHISmaIDAFPELNHEQLKQHITSLLSDTPDKIIKNSLHGLIEERYLLFMLEQAGID 320
Cdd:pfam03486 237 GLSGPAILQLSSYWRRAILKKGGVTLS--IDLLPDLDAEELAARLEKPRGAHPKKSLKNSLAGLLPKRLAEFLLEQAGIE 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  321 ENTTSHHLSNQQLNDLVNMFKGFVFKVNGTLPIDKAFVTGGGVSLKEIQPKTMMSKLVPGLFLCGEVLDIHGYTGGYNIT 400
Cdd:pfam03486 315 PDKKLAQLSKKELAALAQLLKAWTFTPNGTEGYRTAEVTAGGVDTKELSSKTMESKKVPGLFFAGEVLDVDGWTGGYNLQ 394

                         410
                  ....*....|..
gi 446207165  401 SALVTGHVAGLY 412
Cdd:pfam03486 395 WAWSSGYAAGQG 406
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
5-416 0e+00

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 512.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   5 IIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGRCNVTNRLPYAEIIKNIPGNGKFLYSPFSIFDNESIID 84
Cdd:COG2081    1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKVGRKILISGGGRCNFTNSEPLPEFLNYYGGNPHFLKSALSRFTPEDLIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  85 FFESRGVKLKEEDHGRMFPVSNKAQDVVDTLVTTIERQHVTIKEEEAVSRIEVnTDQTFTVHTQNN-SYESHSLVIATGG 163
Cdd:COG2081   81 FFEGLGIETKEESSGRVFPDSSKASDILRALLAELREAGVEIRLRTRVTGIEK-EDGGFGVETPDGeTVRADAVVLATGG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165 164 TSVPQTGSTGDGYKFAQDLGHTITELFPTEVPITSAEPFIKsnRLKGLSLKDVELSVlkkNGKKRISHQMDMLFTHFGIS 243
Cdd:COG2081  160 LSYPKLGSTGDGYRLAEQFGHTITPLRPALVPLTLSEHFFK--RLAGLSLKNVALSV---GGKKIASFRGELLFTHRGLS 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165 244 GPAALRCSQFVYKEQKNQKtqhISMAIDAFPELNHEQLKQHITSLLSDTPDKIIKNSLHGLIEERYLLFMLEQAgiDENT 323
Cdd:COG2081  235 GPAILQLSSYWRDALKKGG---ATLTIDLLPDLDLEELDARLARPREKNGKKSLKNVLRGLLPKRLAALLLELA--DPDK 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165 324 TSHHLSNQQLNDLVNMFKGFVFKVNGTLPIDKAFVTGGGVSLKEIQPKTMMSKLVPGLFLCGEVLDIHGYTGGYNITSAL 403
Cdd:COG2081  310 PLAQLSKKEREALAALLKAWPLTPTGTRGYDEAIVTAGGVDTKELDPKTMESKKVPGLYFAGEVLDVDGPTGGYNLQWAW 389

                        410
                 ....*....|...
gi 446207165 404 VTGHVAGLYAGHY 416
Cdd:COG2081  390 SSGYAAGQAAAAW 402
TIGR00275 TIGR00275
flavoprotein, HI0933 family; The model when searched with a partial length search brings in ...
 5-411 1.47e-179

flavoprotein, HI0933 family; The model when searched with a partial length search brings in proteins with a dinucleotide-binding motif (Rossman fold) over the initial 40 residues of the model, including oxidoreductases and dehydrogenases. Partially characterized members include an FAD-binding protein from Bacillus cereus and flavoprotein HI0933 from Haemophilus influenzae. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272992 [Multi-domain]  Cd Length: 400  Bit Score: 505.98  E-value: 1.47e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165    5 IIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGRCNVTNRLPYAEIIKNIPGNGKFLYSPFSIFDNESIID 84
Cdd:TIGR00275   1 IIIGGGAAGLMAAITAARAGLSVLLLEKNKKIGKKLLISGGGRCNLTNSCPTPEFVAYYPRNGKFLRSALSRFSNKDLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   85 FFESRGVKLKEEDHGRMFPVSNKAQDVVDTLVTTIERQHVTIKEEEAVSRIEvNTDQTFTVHTQNNSYESHSLVIATGGT 164
Cdd:TIGR00275  81 FFESLGLELKVEEDGRVFPCSDSAADVLDALLNELKELGVEILTNSKVKSIE-KEDGGFGVETSGGEYEADKVIIATGGL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  165 SVPQTGSTGDGYKFAQDLGHTITELFPTEVPITSAEPFIKsnRLKGLSLKDVELSvlKKNGKKRISHQMDMLFTHFGISG 244
Cdd:TIGR00275 160 SYPQLGSTGDGYEIAESLGHTIVPPVPALVPLTLDESFLK--ELSGISLDGVVLS--LVNGKKVLEEFGELLFTHFGLSG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  245 PAALRCSQFVYKEQKNQKTQhiSMAIDAFPELNHEQLKQHITSLLSDTPDKIIKNSLHGLIEERYLLFMLEQAGIDENTT 324
Cdd:TIGR00275 236 PAILDLSAFAARALLKHKGV--ELEIDLLPDLSEEELEQRLKRLRKSNPKKTVKNILKGLLPKRLAELLLEQLGIDPDLP 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  325 SHHLSNQQLNDLVNMFKGFVFKVNGTLPIDKAFVTGGGVSLKEIQPKTMMSKLVPGLFLCGEVLDIHGYTGGYNITSALV 404
Cdd:TIGR00275 314 AAQLSKKEIKKLVQLLKNWPFTISGTRGFKEAEVTAGGVSLKEINPKTMESKLVPGLYFAGEVLDIDGDTGGYNLQWAWS 393


                  ....*..
gi 446207165  405 TGHVAGL 411
Cdd:TIGR00275 394 SGYLAGK 400
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 5-183 8.11e-11

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 63.31  E-value: 8.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   5 IIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGrCNVTN------------RLPYAEIIKnipgNGKFLYS 72
Cdd:COG1053    7 VVVGSGGAGLRAALEAAEAGLKVLVLEKVPPRGGHTAAAQGG-INAAGtnvqkaagedspEEHFYDTVK----GGDGLAD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  73 P--FSIFDNES--IIDFFESRGVKLKEEDHGR------------MFPVSNKAQDVVDTLVTTIERQHVTIKEEEAVSRIE 136
Cdd:COG1053   82 QdlVEALAEEApeAIDWLEAQGVPFSRTPDGRlpqfgghsvgrtCYAGDGTGHALLATLYQAALRLGVEIFTETEVLDLI 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165 137 VNTDQTFTVHTQNNS-----YESHSLVIATGG------------------TSVPQTGSTGDGYKFAQDLG 183
Cdd:COG1053  162 VDDGRVVGVVARDRTgeivrIRAKAVVLATGGfgrnyemraeylpeaegaLSTNAPGNTGDGIAMALRAG 231
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
2-162 7.21e-10

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 59.75  E-value: 7.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   2 YQTIIIGGGPSGLMAAVAASEQSSSVLLIEKKKGlgrklkisgGGRCNVTNRlpyaeiIKNIPGngkflyspfsifdnes 81
Cdd:COG0492    1 YDVVIIGAGPAGLTAAIYAARAGLKTLVIEGGEP---------GGQLATTKE------IENYPG---------------- 49

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  82 iidffesrgvklkeedhgrmFPVSNKAQDVVDTLVTTIERQHVTIKEEEaVSRIEVnTDQTFTVHTQN-NSYESHSLVIA 160
Cdd:COG0492   50 --------------------FPEGISGPELAERLREQAERFGAEILLEE-VTSVDK-DDGPFRVTTDDgTEYEAKAVIIA 107


                 ..
gi 446207165 161 TG 162
Cdd:COG0492  108 TG 109
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 5-195 1.75e-05

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 46.51  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165    5 IIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGrCNVTNRLPYAEI----------IKNIPGNGKFLYSpf 74
Cdd:pfam00890   3 LVIGGGLAGLAAALAAAEAGLKVAVVEKGQPFGGATAWSSGG-IDALGNPPQGGIdspelhptdtLKGLDELADHPYV-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   75 SIFDNES--IIDFFESRGVKLKEEDHGR---------------MFPVSNKAQD------VVDTLVTTIERQHVTIKEEEA 131
Cdd:pfam00890  80 EAFVEAApeAVDWLEALGVPFSRTEDGHldlrplgglsatwrtPHDAADRRRGlgtghaLLARLLEGLRKAGVDFQPRTA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  132 VSRIEVNTDQ--TFTVHTQNNSYE-----SHSLVIATGG-----------------TSVPqtGSTGDGYKFAQDLGHTIT 187
Cdd:pfam00890 160 ADDLIVEDGRvtGAVVENRRNGREvriraIAAVLLATGGfgrlaelllpaagyadtTNPP--ANTGDGLALALRAGAALT 237


                  ....*...
gi 446207165  188 ELFPTEVP 195
Cdd:pfam00890 238 DDLMEFVQ 245
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 2-166 5.77e-05

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 44.62  E-value: 5.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165    2 YQTIIIGGGPSGLMAAVAASEQSSSVLLIEkkKGLGRKLKISGGG---RCNVTNRLPYAEIIKNIpgNGKFLYSPFSIFd 78
Cdd:TIGR02032   1 YDVVVVGAGPAGASAAYRLADKGLRVLLLE--KKSFPRYKPCGGAlspRALEELDLPGELIVNLV--RGARFFSPNGDS- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   79 nesiidffesrgVKLKEEDhGRMFPVSNKAQDvvDTLVTTIERQHVTIKEEEAVSRIEVNTDQTFTVH-TQNNSYESHSL 157
Cdd:TIGR02032  76 ------------VEIPIET-ELAYVIDRDAFD--EQLAERAQEAGAELRLGTRVLDVEIHDDRVVVIVrGSEGTVTAKIV 140


                  ....*....
gi 446207165  158 VIATGGTSV 166
Cdd:TIGR02032 141 IGADGSRSI 149
FAD_oxidored pfam12831
FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases ...
 5-31 1.65e-04

FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases and related proteins.


Pssm-ID: 432816 [Multi-domain]  Cd Length: 420  Bit Score: 43.75  E-value: 1.65e-04
                          10        20
                  ....*....|....*....|....*..
gi 446207165    5 IIIGGGPSGLMAAVAASEQSSSVLLIE 31
Cdd:pfam12831   3 VVVGGGPAGVAAAIAAARAGAKVLLVE 29
PRK06753 PRK06753
hypothetical protein; Provisional
 5-185 2.58e-04

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 42.75  E-value: 2.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   5 IIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGRcNVTNRLPYAEIIKNIPGNGKFLySPFSIFDnesiid 84
Cdd:PRK06753   4 AIIGAGIGGLTAAALLQEQGHEVKVFEKNESVKEVGAGIGIGD-NVIKKLGNHDLAKGIKNAGQIL-STMNLLD------ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  85 ffesrgvklkeeDHGRMFpvsNKAQDVVDTLVTTIERQHV-----------TIKEEEAVSRIEVNTDQTfTVHTQNNSYE 153
Cdd:PRK06753  76 ------------DKGTLL---NKVKLKSNTLNVTLHRQTLidiiksyvkedAIFTGKEVTKIENETDKV-TIHFADGESE 139

                        170       180       190
                 ....*....|....*....|....*....|....
gi 446207165 154 SHSLVIATGG--TSVPQTGSTGDGYKFAqdlGHT 185
Cdd:PRK06753 140 AFDLCIGADGihSKVRQSVNADSKVRYQ---GYT 170
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
120-167 9.50e-04

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 41.06  E-value: 9.50e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 446207165  120 ERQHVTIKEEEAVSRIEVNtDQTFTVHTQNNSYESHSLVIATGGTSVP 167
Cdd:pfam13738  86 DHFELPINLFEEVTSVKKE-DDGFVVTTSKGTYQARYVIIATGEFDFP 132
PRK08274 PRK08274
FAD-dependent tricarballylate dehydrogenase TcuA;
1-31 9.96e-04

FAD-dependent tricarballylate dehydrogenase TcuA;


Pssm-ID: 236214 [Multi-domain]  Cd Length: 466  Bit Score: 41.40  E-value: 9.96e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 446207165   1 MYQTIIIGGGPSGLMAAVAASEQSSSVLLIE 31
Cdd:PRK08274   4 MVDVLVIGGGNAALCAALAAREAGASVLLLE 34
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-195 1.12e-03

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 40.69  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   1 MYQTIIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRK---LKISGGG-----RCNVTNRL-----PYAEIIKNIPGNG 67
Cdd:COG0654    3 RTDVLIVGGGPAGLALALALARAGIRVTVVERAPPPRPDgrgIALSPRSlellrRLGLWDRLlargaPIRGIRVRDGSDG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  68 KFLYSpfsiFDnesiidffesrgvkLKEEDHGRMFPVSNkaQDVVDTLVTTIERQHVTIKEEEAVSRIEVNTDQTfTVHT 147
Cdd:COG0654   83 RVLAR----FD--------------AAETGLPAGLVVPR--ADLERALLEAARALGVELRFGTEVTGLEQDADGV-TVTL 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446207165 148 QNNSYESHSLVI-ATGGTSV--PQTGSTGDGYKFAQ-----DLGHTITELFPTEVP 195
Cdd:COG0654  142 ADGRTLRADLVVgADGARSAvrRLLGIGFTGRDYPQralwaGVRTELRARLAAAGP 197
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 1-195 1.65e-03

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 40.46  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   1 MYQTIIIGGGPSGLMAAVAASEQSSSVLLIEKKKGlgrklkisgGGRCnvTNR--LP---------YAEIIKNIPGNGkf 69
Cdd:COG1249    3 DYDLVVIGAGPGGYVAAIRAAQLGLKVALVEKGRL---------GGTC--LNVgcIPskallhaaeVAHEARHAAEFG-- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  70 LYSPFSIFDNESIIDFfeSRGVklkeedhgrmfpVSNKAQDVVDTLvttiERQHVTIKEEEAV----SRIEVNTDQTftv 145
Cdd:COG1249   70 ISAGAPSVDWAALMAR--KDKV------------VDRLRGGVEELL----KKNGVDVIRGRARfvdpHTVEVTGGET--- 128

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446207165 146 htqnnsYESHSLVIATGGT-SVPqtgstgDGYKFAQDLGHTITELF-PTEVP 195
Cdd:COG1249  129 ------LTADHIVIATGSRpRVP------PIPGLDEVRVLTSDEALeLEELP 168
PRK05329 PRK05329
glycerol-3-phosphate dehydrogenase subunit GlpB;
1-30 1.77e-03

glycerol-3-phosphate dehydrogenase subunit GlpB;


Pssm-ID: 235412  Cd Length: 422  Bit Score: 40.22  E-value: 1.77e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 446207165   1 MYQTIIIGGGPSGLMAAVAASEQSSSVLLI 30
Cdd:PRK05329   2 KFDVLVIGGGLAGLTAALAAAEAGKRVALV 31
sdhA PRK07803
succinate dehydrogenase flavoprotein subunit; Reviewed
 361-417 1.89e-03

succinate dehydrogenase flavoprotein subunit; Reviewed


Pssm-ID: 236101 [Multi-domain]  Cd Length: 626  Bit Score: 40.40  E-value: 1.89e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165 361 GGVslkEIQPKTMMSKlVPGLFLCGEVL-DIHGYT--GGYNITSALVTGHVAGLYAGHYS 417
Cdd:PRK07803 392 GGV---EVDPDTGAAT-VPGLFAAGECAgGMHGSNrlGGNSLSDLLVFGRRAGLGAADYV 447
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
6-31 3.78e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 35.58  E-value: 3.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 446207165    6 IIGGGPSGLMAAVAASEQSSSVLLIE 31
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLE 26
GlpB COG3075
Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism];
2-30 3.80e-03

Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism];


Pssm-ID: 442309  Cd Length: 415  Bit Score: 39.39  E-value: 3.80e-03
                         10        20
                 ....*....|....*....|....*....
gi 446207165   2 YQTIIIGGGPSGLMAAVAASEQSSSVLLI 30
Cdd:COG3075    3 FDVVVIGGGLAGLTAAIRAAEAGLRVAIV 31
PRK06481 PRK06481
flavocytochrome c;
2-189 4.29e-03

flavocytochrome c;


Pssm-ID: 180584 [Multi-domain]  Cd Length: 506  Bit Score: 39.43  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   2 YQTIIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGR------------CNVTNRLPYAEIIKNIPG-NGK 68
Cdd:PRK06481  62 YDIVIVGAGGAGMSAAIEAKDAGMNPVILEKMPVAGGNTMKASSGMnasetkfqkaqgIADSNDKFYEETLKGGGGtNDK 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165  69 FLYSPFsiFDNE-SIIDFFESRGVKL---------KEEDHGRMFPVSNKAQDVVDTLVTTIERQHVTI----------KE 128
Cdd:PRK06481 142 ALLRYF--VDNSaSAIDWLDSMGIKLdnltitggmSEKRTHRPHDGSAVGGYLVDGLLKNVQERKIPLfvnadvtkitEK 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165 129 EEAVSRIEV--NTDQTFTVhtqnnsyESHSLVIATGG------------------TSVPQTGSTGDGYKFAQDLGHTITE 188
Cdd:PRK06481 220 DGKVTGVKVkiNGKETKTI-------SSKAVVVTTGGfgankdmiakyrpdlkgyVTTNQEGSTGDGIKMIEKLGGTTVD 292


                 .
gi 446207165 189 L 189
Cdd:PRK06481 293 M 293
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 1-31 6.61e-03

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 38.66  E-value: 6.61e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 446207165   1 MYQTIIIGGGPSGLMAAVAASEQSSSVLLIE 31
Cdd:COG1232    1 MKRVAVIGGGIAGLTAAYRLAKAGHEVTVLE 31
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 2-31 8.30e-03

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 38.08  E-value: 8.30e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 446207165    2 YQTIIIGGGPSGLMAAVAASEQSSSVLLIE 31
Cdd:pfam01494   2 TDVLIVGGGPAGLMLALLLARAGVRVVLVE 31
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 2-165 9.85e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 37.68  E-value: 9.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165    2 YQTIIIGGGPSGLMAAVAASEQSSSVLLIEKkkglgrklkisgGGRCnVTNRLPYAEIIKNIPGNGKFLYSPFSIFDNES 81
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIED------------EGTC-PYGGCVLSKALLGAAEAPEIASLWADLYKRKE 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446207165   82 IIDFFESRGVKLkeedhgrmfpvsnkaqdVVDTLVTTIERQHVTIKEEEAVsrievnTDQTFTvhtqnnsYESHSLVIAT 161
Cdd:pfam07992  68 EVVKKLNNGIEV-----------------LLGTEVVSIDPGAKKVVLEELV------DGDGET-------ITYDRLVIAT 117


                  ....
gi 446207165  162 GGTS 165
Cdd:pfam07992 118 GARP 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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