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Conserved domains on  [gi|446222447|ref|WP_000300302|]
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DUF4329 domain-containing protein, partial [Escherichia coli]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4329 super family cl16721
Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found ...
 43-161 1.79e-12

Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found in bacteria and eukaryotes, and is approximately 130 amino acids in length. It is often found in association with pfam05593 and pfam03527. There is a single completely conserved residue D and a highly conserved HTH motif which may be functionally important.


The actual alignment was detected with superfamily member pfam14220:

Pssm-ID: 433783  Cd Length: 114  Bit Score: 60.86  E-value: 1.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446222447   43 ALAMCNGESINENKEYGGLICKKQGEYFPMNPISSNDNDSVDLRNikCPEGSERVGDYHTHGFYSDDkgnkvtkendvYD 122
Cdd:pfam14220   6 ALEEYNGRSIRENREYCGFILTDDEGKYVYTAPTRGGEASSGNPP--VPNGQTVVASYHTHGAYDSN-----------YD 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446222447  123 SLNFSSKD--LTNSYMNGmgkkEYSSYLGTPNNTYLKYNPK 161
Cdd:pfam14220  73 SEVFSVQDkkIVLSDMQN----GVNGYVATPGGRLWYIDPS 109
RHS_core super family cl49306
RHS element core protein;
1-28 9.96e-12

RHS element core protein;


The actual alignment was detected with superfamily member NF041261:

Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 62.33  E-value: 9.96e-12
                          10        20
                  ....*....|....*....|....*...
gi 446222447    1 QDPIGLKGGWNLYTYPLSPVNSMDPLGL 28
Cdd:NF041261 1234 QDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
 
Name Accession Description Interval E-value
DUF4329 pfam14220
Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found ...
 43-161 1.79e-12

Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found in bacteria and eukaryotes, and is approximately 130 amino acids in length. It is often found in association with pfam05593 and pfam03527. There is a single completely conserved residue D and a highly conserved HTH motif which may be functionally important.


Pssm-ID: 433783  Cd Length: 114  Bit Score: 60.86  E-value: 1.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446222447   43 ALAMCNGESINENKEYGGLICKKQGEYFPMNPISSNDNDSVDLRNikCPEGSERVGDYHTHGFYSDDkgnkvtkendvYD 122
Cdd:pfam14220   6 ALEEYNGRSIRENREYCGFILTDDEGKYVYTAPTRGGEASSGNPP--VPNGQTVVASYHTHGAYDSN-----------YD 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446222447  123 SLNFSSKD--LTNSYMNGmgkkEYSSYLGTPNNTYLKYNPK 161
Cdd:pfam14220  73 SEVFSVQDkkIVLSDMQN----GVNGYVATPGGRLWYIDPS 109
RHS_core NF041261
RHS element core protein;
1-28 9.96e-12

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 62.33  E-value: 9.96e-12
                          10        20
                  ....*....|....*....|....*...
gi 446222447    1 QDPIGLKGGWNLYTYPLSPVNSMDPLGL 28
Cdd:NF041261 1234 QDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
 1-28 1.99e-06

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 43.64  E-value: 1.99e-06
                          10        20
                  ....*....|....*....|....*....
gi 446222447    1 QDPIGLKGGWNLYTY-PLSPVNSMDPLGL 28
Cdd:TIGR03696  49 PDPIGLGGGLNLYAYvGNNPVNWVDPLGL 77
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 1-43 2.39e-06

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 46.67  E-value: 2.39e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 446222447    1 QDPIGLKGGWNLYTYPL-SPVNSMDPLGLYEFKSKNIDDIGIFA 43
Cdd:COG3209   997 PDPIGLAGGLNLYAYVGnNPVNYVDPLGLAALLGTTGLGGGAGV 1040
 
Name Accession Description Interval E-value
DUF4329 pfam14220
Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found ...
 43-161 1.79e-12

Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found in bacteria and eukaryotes, and is approximately 130 amino acids in length. It is often found in association with pfam05593 and pfam03527. There is a single completely conserved residue D and a highly conserved HTH motif which may be functionally important.


Pssm-ID: 433783  Cd Length: 114  Bit Score: 60.86  E-value: 1.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446222447   43 ALAMCNGESINENKEYGGLICKKQGEYFPMNPISSNDNDSVDLRNikCPEGSERVGDYHTHGFYSDDkgnkvtkendvYD 122
Cdd:pfam14220   6 ALEEYNGRSIRENREYCGFILTDDEGKYVYTAPTRGGEASSGNPP--VPNGQTVVASYHTHGAYDSN-----------YD 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446222447  123 SLNFSSKD--LTNSYMNGmgkkEYSSYLGTPNNTYLKYNPK 161
Cdd:pfam14220  73 SEVFSVQDkkIVLSDMQN----GVNGYVATPGGRLWYIDPS 109
RHS_core NF041261
RHS element core protein;
1-28 9.96e-12

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 62.33  E-value: 9.96e-12
                          10        20
                  ....*....|....*....|....*...
gi 446222447    1 QDPIGLKGGWNLYTYPLSPVNSMDPLGL 28
Cdd:NF041261 1234 QDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
 1-28 1.99e-06

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 43.64  E-value: 1.99e-06
                          10        20
                  ....*....|....*....|....*....
gi 446222447    1 QDPIGLKGGWNLYTY-PLSPVNSMDPLGL 28
Cdd:TIGR03696  49 PDPIGLGGGLNLYAYvGNNPVNWVDPLGL 77
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 1-43 2.39e-06

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 46.67  E-value: 2.39e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 446222447    1 QDPIGLKGGWNLYTYPL-SPVNSMDPLGLYEFKSKNIDDIGIFA 43
Cdd:COG3209   997 PDPIGLAGGLNLYAYVGnNPVNYVDPLGLAALLGTTGLGGGAGV 1040
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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