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Conserved domains on  [gi|446259664|ref|WP_000337519|]
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MULTISPECIES: RNA polymerase subunit sigma-70 [Bacillus]

Protein Classification

PRK06704 family protein( domain architecture ID 11482397)

PRK06704 family protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK06704 PRK06704
RNA polymerase subunit sigma-70;
1-228 6.22e-163

RNA polymerase subunit sigma-70;


:

Pssm-ID: 180663 [Multi-domain]  Cd Length: 228  Bit Score: 449.09  E-value: 6.22e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664   1 MCTKVTHVLKNHIDMNHSNINFLIEQYGELKRYCTFLTKNKWDGEDLAQETVCKVLQKYRNKEICMTLVYKIARNRWLDQ 80
Cdd:PRK06704   1 MCTKVTHILKNHIDMNHSNINFLIEQYGELKRYCTFLTKNKWDGEDLAQETVCKVLQKYSNKDICMTLVYKIARNRWLDQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  81 MKSKSVHEKIREQITFEEPHENIADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRL 160
Cdd:PRK06704  81 IKSKSVHEKIRDQITFEEPHEKIADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRL 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446259664 161 KTVSEEGIEIVEFTEDIEVVVTSIREERPELLTKLLPTIDFTKLPSKQPVLLFNVKNPSSYSYMLYAA 228
Cdd:PRK06704 161 KTVSEEGIEIVEFTDDMEVVVTSIREERPELLTKLLPTIDFTKLPSKQPVLLFNVKQPSSYSCMLCVA 228
 
Name Accession Description Interval E-value
PRK06704 PRK06704
RNA polymerase subunit sigma-70;
1-228 6.22e-163

RNA polymerase subunit sigma-70;


Pssm-ID: 180663 [Multi-domain]  Cd Length: 228  Bit Score: 449.09  E-value: 6.22e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664   1 MCTKVTHVLKNHIDMNHSNINFLIEQYGELKRYCTFLTKNKWDGEDLAQETVCKVLQKYRNKEICMTLVYKIARNRWLDQ 80
Cdd:PRK06704   1 MCTKVTHILKNHIDMNHSNINFLIEQYGELKRYCTFLTKNKWDGEDLAQETVCKVLQKYSNKDICMTLVYKIARNRWLDQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  81 MKSKSVHEKIREQITFEEPHENIADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRL 160
Cdd:PRK06704  81 IKSKSVHEKIRDQITFEEPHEKIADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRL 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446259664 161 KTVSEEGIEIVEFTEDIEVVVTSIREERPELLTKLLPTIDFTKLPSKQPVLLFNVKNPSSYSYMLYAA 228
Cdd:PRK06704 161 KTVSEEGIEIVEFTDDMEVVVTSIREERPELLTKLLPTIDFTKLPSKQPVLLFNVKQPSSYSCMLCVA 228
RpoE COG1595
DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; ...
23-161 1.76e-28

DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; DNA-directed RNA polymerase specialized sigma subunit, sigma24 family is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 441203 [Multi-domain]  Cd Length: 181  Bit Score: 105.85  E-value: 1.76e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  23 LIEQY-GELKRYCTFLTKNKWDGEDLAQETVCKVLQK---YRNKEICMTLVYKIARNRWLDQMKSKSVHEKIREQITFEE 98
Cdd:COG1595   22 LYERYrPRLYRYARRLLGDRADAEDLVQETFLRLWRKldsFRGRGSFRAWLYRIARNLAIDHLRKRRRRRELLDELAEEL 101
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446259664  99 PHENI--------ADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLK 161
Cdd:COG1595  102 PDEAAdpeealeaEELLEALLAALERLPPRQREVLVLRYLEGLSYAEIAEILGISEGTVKSRLSRARKKLR 172
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
23-161 2.33e-21

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 86.63  E-value: 2.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664   23 LIEQYGE-LKRYCTFLTKNKWDGEDLAQETVCKVLQ---KYRNKEICMTLVYKIARNRWLDQMKSKSVHEKIREQI---- 94
Cdd:TIGR02937   6 LYERYLPlVYRYARRYLGDDADAEDLVQEAFLKLLEaldRFDPEGSFKAWLFRIARNLILDYLRRKRRLRRELDLLeell 85
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664   95 -TFEEPHENI--ADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLK 161
Cdd:TIGR02937  86 dSDPSPEEELeqEEEREALREALEKLPEREREVLVLRYLEGLSYKEIAEILGISVGTVKRRLKRARKKLR 155
Sigma70_r4_2 pfam08281
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
107-160 1.42e-09

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif.


Pssm-ID: 400535 [Multi-domain]  Cd Length: 54  Bit Score: 52.46  E-value: 1.42e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 446259664  107 HEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRL 160
Cdd:pfam08281   1 LEALLRALEELPPRQREVFLLRYLEGLSYAEIAELLGISEGTVKSRLSRARKKL 54
Sigma70_r4 cd06171
Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in ...
107-161 1.83e-03

Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or plastid core RNA polymerase to specific promoter elements located upstream of transcription initiation points. The SR4 of Ec sigma70 and other essential primary SFs contact promoter sequences located 35 base-pairs upstream of the initiation point, recognizing a 6-base-pair -35 consensus TTGACA. Sigma70 related SFs also include SFs which are dispensable for bacterial cell growth for example Ec sigmaS, SFs which activate regulons in response to a specific signal for example heat-shock Ec sigmaH, and a group of SFs which includes the extracytoplasmic function (ECF) SFs and is typified by Ec sigmaE which contains SR2 and -4 only. ECF SFs direct the transcription of genes that regulate various responses including periplasmic stress and pathogenesis. Ec sigmaE SR4 also contacts the -35 element, but recognizes a different consensus (a 7-base-pair GGAACTT). Plant SFs recognize sigma70 type promoters and direct transcription of the major plastid RNA polymerase, plastid-encoded RNA polymerase (PEP).


Pssm-ID: 100119 [Multi-domain]  Cd Length: 55  Bit Score: 35.54  E-value: 1.83e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446259664 107 HEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLK 161
Cdd:cd06171    1 RERLEEALDKLPEREREVILLRFGEGLSYEEIAEILGISRSTVRQRLHRALKKLR 55
 
Name Accession Description Interval E-value
PRK06704 PRK06704
RNA polymerase subunit sigma-70;
1-228 6.22e-163

RNA polymerase subunit sigma-70;


Pssm-ID: 180663 [Multi-domain]  Cd Length: 228  Bit Score: 449.09  E-value: 6.22e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664   1 MCTKVTHVLKNHIDMNHSNINFLIEQYGELKRYCTFLTKNKWDGEDLAQETVCKVLQKYRNKEICMTLVYKIARNRWLDQ 80
Cdd:PRK06704   1 MCTKVTHILKNHIDMNHSNINFLIEQYGELKRYCTFLTKNKWDGEDLAQETVCKVLQKYSNKDICMTLVYKIARNRWLDQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  81 MKSKSVHEKIREQITFEEPHENIADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRL 160
Cdd:PRK06704  81 IKSKSVHEKIRDQITFEEPHEKIADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRL 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446259664 161 KTVSEEGIEIVEFTEDIEVVVTSIREERPELLTKLLPTIDFTKLPSKQPVLLFNVKNPSSYSYMLYAA 228
Cdd:PRK06704 161 KTVSEEGIEIVEFTDDMEVVVTSIREERPELLTKLLPTIDFTKLPSKQPVLLFNVKQPSSYSCMLCVA 228
RpoE COG1595
DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; ...
23-161 1.76e-28

DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; DNA-directed RNA polymerase specialized sigma subunit, sigma24 family is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 441203 [Multi-domain]  Cd Length: 181  Bit Score: 105.85  E-value: 1.76e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  23 LIEQY-GELKRYCTFLTKNKWDGEDLAQETVCKVLQK---YRNKEICMTLVYKIARNRWLDQMKSKSVHEKIREQITFEE 98
Cdd:COG1595   22 LYERYrPRLYRYARRLLGDRADAEDLVQETFLRLWRKldsFRGRGSFRAWLYRIARNLAIDHLRKRRRRRELLDELAEEL 101
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446259664  99 PHENI--------ADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLK 161
Cdd:COG1595  102 PDEAAdpeealeaEELLEALLAALERLPPRQREVLVLRYLEGLSYAEIAEILGISEGTVKSRLSRARKKLR 172
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
23-161 2.33e-21

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 86.63  E-value: 2.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664   23 LIEQYGE-LKRYCTFLTKNKWDGEDLAQETVCKVLQ---KYRNKEICMTLVYKIARNRWLDQMKSKSVHEKIREQI---- 94
Cdd:TIGR02937   6 LYERYLPlVYRYARRYLGDDADAEDLVQEAFLKLLEaldRFDPEGSFKAWLFRIARNLILDYLRRKRRLRRELDLLeell 85
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664   95 -TFEEPHENI--ADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLK 161
Cdd:TIGR02937  86 dSDPSPEEELeqEEEREALREALEKLPEREREVLVLRYLEGLSYKEIAEILGISVGTVKRRLKRARKKLR 155
PRK11924 PRK11924
RNA polymerase sigma factor; Provisional
27-161 7.22e-13

RNA polymerase sigma factor; Provisional


Pssm-ID: 183384 [Multi-domain]  Cd Length: 179  Bit Score: 64.61  E-value: 7.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  27 YGELKRYCTFLTKNKWDGEDLAQETVCKVLQ---KYRNKEICMTLVYKIARN--------RWLDQMKSKSVHEKIREQIT 95
Cdd:PRK11924  23 APDLLRYARRQLGDRALAEDAVQEAFLRAWRkadLFNGKGSARTWLLTIARNvcydllrrRRREKAVLSDDALEPEFAET 102
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446259664  96 FEEPHENI--ADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLK 161
Cdd:PRK11924 103 AETPEAALlaKDDLARIDRCLDALPVKQREVFLLRYVEGLSYREIAEILGVPVGTVKSRLRRARQLLR 170
SigM_subfam TIGR02950
RNA polymerase sigma factor, SigM family; This family of RNA polymerase sigma factors is a ...
24-165 5.75e-11

RNA polymerase sigma factor, SigM family; This family of RNA polymerase sigma factors is a member of the Sigma-70 subfamily (TIGR02937) and is restricted to certain lineages of the order Bacillales. This family encompasses at least two distinct sigma factors as two proteins are found in each of B. anthracis, B. subtilis subsp. subtilis str. 168, and B. lichiniformis (although these are not apparently the same two in each). One of these is designated as SigM in B. subtilis (Swiss_Prot:


Pssm-ID: 274361 [Multi-domain]  Cd Length: 154  Bit Score: 58.62  E-value: 5.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664   24 IEQYGELKRYCTFLTKNKWDGEDLAQETVCKV---LQKYRNKEIcMTLVYKIARNRWLDQMKSKSVHEKI-------REQ 93
Cdd:TIGR02950   2 REYMHDVFRYLYRLTKDKHLAEDLLQETFLKAyihLHSFKDSSI-KPWLFRIARNAFIDWYRKDKKIQTIdddaigdLEQ 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446259664   94 ITFEEP--HENIADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLKTVSE 165
Cdd:TIGR02950  81 HPVESPehHLLIKIEQEEITHHLSRLPENYRTVLILREFKEFSYKEIAELLNLSLAKVKSNLFRARKELKKLLE 154
PRK12541 PRK12541
RNA polymerase sigma factor; Provisional
25-165 6.41e-11

RNA polymerase sigma factor; Provisional


Pssm-ID: 183580 [Multi-domain]  Cd Length: 161  Bit Score: 58.79  E-value: 6.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  25 EQYGELKRYCTFLTKNKWDGEDLAQETVCKVL---QKYRNKEIcMTLVYKIARNRWLDQMKSksvhEKIREQITFEEPH- 100
Cdd:PRK12541  13 EHMQDLFRYLLSLTGDSHFAEDLMQETFYRMLvhiDYYKGEEI-RPWLFTIAYNAFIDWYRK----EKKYKTTTIEEFHl 87
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446259664 101 -------ENIADLHEMVGKV--LSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLKTVSE 165
Cdd:PRK12541  88 pnvpsteHEYFIKHEIASWLdsLSSLPLERRNVLLLRDYYGFSYKEIAEMTGLSLAKVKIELHRGRKETKSIKE 161
PRK09639 PRK09639
RNA polymerase sigma factor SigX; Provisional
27-166 6.70e-11

RNA polymerase sigma factor SigX; Provisional


Pssm-ID: 236602 [Multi-domain]  Cd Length: 166  Bit Score: 58.81  E-value: 6.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  27 YGELKRYCTFLTKNKWDGEDLAQETVCKVL-QKYRNKEICMTLVYKIARNRWLDQMKSKSVHeKIRE-------QITFEE 98
Cdd:PRK09639  13 YPDVVQQIFYIVKDRTQAEDLAQEVFLRLYrSDFKGIENEKGWLIKSARNVAYNYLRSEKRR-RARIlgefqwqEVDNEP 91
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446259664  99 PHENIADLHEMVGKV---LSSLNVQQSAILLLKdvFQ-YSIADIAKVCSVSEGAVKASLFRSRNRLKTVSEE 166
Cdd:PRK09639  92 SPEEIWIRKEEITKVqevLAKMTERDRTVLLLR--FSgYSYKEIAEALGIKESSVGTTLARAKKKFRKIYEQ 161
PRK09415 PRK09415
RNA polymerase factor sigma C; Reviewed
39-167 1.11e-10

RNA polymerase factor sigma C; Reviewed


Pssm-ID: 181835 [Multi-domain]  Cd Length: 179  Bit Score: 58.61  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  39 KNKWDGEDLAQETVCKVLQK---YRNKEICMTLVYKIARNRWLDQMKS---KSVH--EKIREQI--TFEEPHENI---AD 105
Cdd:PRK09415  38 KNKEVAEDLTQEIFVKCYKSlhtYKGKSSLKTWLYRIAINHCKDYLKSwhnKKVIvtEDIFTYMesQKESVEEEViqnAE 117
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446259664 106 LHEMVGKVLSsLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLKTVSEEG 167
Cdd:PRK09415 118 DERLASAVMS-LPIKYREVIYLFYYEELSIKEIAEVTGVNENTVKTRLKKAKELLKKGLEEE 178
Sigma70_r4_2 pfam08281
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
107-160 1.42e-09

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif.


Pssm-ID: 400535 [Multi-domain]  Cd Length: 54  Bit Score: 52.46  E-value: 1.42e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 446259664  107 HEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRL 160
Cdd:pfam08281   1 LEALLRALEELPPRQREVFLLRYLEGLSYAEIAELLGISEGTVKSRLSRARKKL 54
PRK09644 PRK09644
RNA polymerase sigma factor SigM; Provisional
32-166 2.66e-09

RNA polymerase sigma factor SigM; Provisional


Pssm-ID: 170033 [Multi-domain]  Cd Length: 165  Bit Score: 54.50  E-value: 2.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  32 RYCTFLTKNKWDGEDLAQETVCKV---LQKYRNKEIcMTLVYKIARNRWLD----QMKSKSVHEKIREQITFEEPHENIA 104
Cdd:PRK09644  16 RYLFSLTKSHHAAEDLLQETFYRAyiyLEDYDNQKV-KPWLFKVAYHTFIDfvrkEKKVSFVGTDEIEAIQAESTEEYVV 94
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446259664 105 --DLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLKTVSEE 166
Cdd:PRK09644  95 akNSYEKLIQIIHTLPVIEAQAILLCDVHELTYEEAASVLDLKLNTYKSHLFRGRKRLKALLKE 158
PRK09638 PRK09638
RNA polymerase sigma factor SigY; Reviewed
23-154 3.84e-09

RNA polymerase sigma factor SigY; Reviewed


Pssm-ID: 182010 [Multi-domain]  Cd Length: 176  Bit Score: 54.26  E-value: 3.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  23 LIEQ-YGELKRYCTFLTKNKWDGEDLAQETVCKV---LQKYRNKEICMTLVYKIARNRWLDQMKSKSVHEKIREQITFEE 98
Cdd:PRK09638  23 LFQQhYSFLYKYLLKLTLDPDLAEDLVQETMLKAienLSSFQGRSKFSTWLISIASRLYKDHLRKQKREKLRLQRAKEET 102
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446259664  99 PHENI-------ADLHEMVgKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLF 154
Cdd:PRK09638 103 LRKEKweaaikgAEWSEML-DALSKLDPEFRAPVILKHYYGYTYEEIAKMLNIPEGTVKSRVH 164
PRK12522 PRK12522
RNA polymerase sigma factor; Provisional
20-165 4.52e-08

RNA polymerase sigma factor; Provisional


Pssm-ID: 183571 [Multi-domain]  Cd Length: 173  Bit Score: 51.02  E-value: 4.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  20 INFLIEQYGE-LKRYCTFLTKNKWDGEDLAQETVCKVLQ---KYRNKEICMTLVYKIARN----------RWLDQMKSkS 85
Cdd:PRK12522   5 VEELIDIYKQqIYSLCYKLAKTKEDAEDIFQETWIKVFSsrhQLSYVENYKKWITTICVRtfydfyrkkkRWKDRILD-L 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  86 VHEKIREQITFEE----PHENIADLH-EMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRL 160
Cdd:PRK12522  84 FHKEDGGEIEFADdvniSEEFIQKVEaEMIREVIQLLNEKYKTVLVLYYYEQYSYKEMSEILNIPIGTVKYRLNYAKKQM 163

                 ....*
gi 446259664 161 KTVSE 165
Cdd:PRK12522 164 REHLE 168
PRK12518 PRK12518
RNA polymerase sigma factor; Provisional
45-169 1.56e-07

RNA polymerase sigma factor; Provisional


Pssm-ID: 237124 [Multi-domain]  Cd Length: 175  Bit Score: 49.72  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  45 EDLAQETVCKV---LQKYRNKEICMTLVYKIARNRWLDQ----MKSKSVHEKIREQITFEEPH--ENIADLH--EMVGKV 113
Cdd:PRK12518  38 DDLVQEVFLRVwkgLPKLRNPAYFSTWLYRITWNVATDArrqfAQRPSRIQDDSLNDQPSRPSdtPDLMQLHyqDLVQQG 117
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446259664 114 LSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLKT-VSEEGIE 169
Cdd:PRK12518 118 LQTLSLEHRAVLVLHDLEDLPQKEIAEILNIPVGTVKSRLFYARRQLRKfLQQQGVL 174
PRK12546 PRK12546
RNA polymerase sigma factor; Provisional
23-183 2.85e-07

RNA polymerase sigma factor; Provisional


Pssm-ID: 139055 [Multi-domain]  Cd Length: 188  Bit Score: 49.07  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  23 LIEQYGELKRYCTFLTKNKWDGEDLAQETVCKV---LQKYRNKEICMTLVYKIARNRWL-DQMKSKSVHEKIREQIT--- 95
Cdd:PRK12546  13 LVEHLPALRAFAISLTRNVAVADDLVQDTIVKAwtnFDKFQEGTNLRAWLFTILRNTFYsDRRKHKREVPDPEGVHAasl 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  96 FEEP-HENIADLHEMvGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLKTVSE-EGIEIVEF 173
Cdd:PRK12546  93 AVKPaHDGRLAMSDF-RAAFAQLPDEQREALILVGASGFSYEEAAEMCGVAVGTVKSRANRARARLAELLQlEEGEELEM 171
                        170
                 ....*....|
gi 446259664 174 TEDIEVVVTS 183
Cdd:PRK12546 172 TDGATLAVMS 181
PRK09640 PRK09640
RNA polymerase sigma factor SigX; Reviewed
30-161 3.53e-07

RNA polymerase sigma factor SigX; Reviewed


Pssm-ID: 236603 [Multi-domain]  Cd Length: 188  Bit Score: 48.78  E-value: 3.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  30 LKRYCTFLTKNKWDGEDLAQETVCKVLQKYRN---KEICMTLVYKIARNRWLDQMKSKSVHEKIREQITF---EEPHENI 103
Cdd:PRK09640  39 LFNVCARYLGNDRDADDVCQEVMLKVLYGLKNfegKSKFKTWLYSITYNECITQYRKERRKRRLMDALSLdplEEASEEK 118
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446259664 104 ADLHEMVG---KVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLK 161
Cdd:PRK09640 119 APKPEERGgldRWLVHVNPIDREILVLRFVAELEFQEIADIMHMGLSATKMRYKRALDKLR 179
PRK12547 PRK12547
RNA polymerase sigma factor; Provisional
30-161 1.17e-06

RNA polymerase sigma factor; Provisional


Pssm-ID: 139056 [Multi-domain]  Cd Length: 164  Bit Score: 47.18  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  30 LKRYCTFLTKNKWDGEDLAQETVCKVLQKYRNKEICMTL---VYKIARNRWLDQMKSK--SVHEK---IREQITFEEPHE 101
Cdd:PRK12547  19 LRAFAVSLSSKHDKAEDLVQDTLMKAWAKQDSFEMGTNLkawLFTILRNEFYSQMRKRgrEVQDSdgvFTARVAVHPAQY 98
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664 102 NIADLHEMvGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLK 161
Cdd:PRK12547  99 GSLDLQDF-KKALNLLSADQREAIILIGASGFSYEDAAAICGCAVGTIKSRVSRARNRLQ 157
PRK09643 PRK09643
RNA polymerase sigma factor SigM; Reviewed
67-160 2.41e-06

RNA polymerase sigma factor SigM; Reviewed


Pssm-ID: 236604 [Multi-domain]  Cd Length: 192  Bit Score: 46.63  E-value: 2.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  67 TLVYKIARNRWLDQMKSKSVHEKIREQITFEEPHENIA-----DLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKV 141
Cdd:PRK09643  80 SWLHRIVVNACLDRLRRAKARPTVPLDDVYPVAQLERDptarvETALAVQRALMRLPVEQRAALVAVDMQGYSVADAARM 159
                         90
                 ....*....|....*....
gi 446259664 142 CSVSEGAVKASLFRSRNRL 160
Cdd:PRK09643 160 LGVAEGTVKSRCARGRARL 178
PRK12536 PRK12536
RNA polymerase sigma factor; Provisional
43-155 2.73e-06

RNA polymerase sigma factor; Provisional


Pssm-ID: 237131 [Multi-domain]  Cd Length: 181  Bit Score: 46.20  E-value: 2.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  43 DGEDLAQETVCKVLQK---YRNKEICMTLVYKIARNRWLDQMKSKSVHEKIREQI-----TFEEPHENIADLHEMVGKVL 114
Cdd:PRK12536  48 EVEDLVQEILLAVHNArhtYRADQPLTAWVHAIARYKLMDFLRSRARREALHDPLddeseLFATSDDEAAEARRDLGKLL 127
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446259664 115 SSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFR 155
Cdd:PRK12536 128 EQLPDRQRLPIVHVKLEGLSVAETAQLTGLSESAVKVGIHR 168
PRK09647 PRK09647
RNA polymerase sigma factor SigE; Reviewed
37-161 1.62e-05

RNA polymerase sigma factor SigE; Reviewed


Pssm-ID: 236606 [Multi-domain]  Cd Length: 203  Bit Score: 44.39  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  37 LTKNKWDGEDLAQETVCKV---LQKYRNKEICMTLvYKIARNRWLDQMKSKSvheKIR--------EQITFEEPHE---- 101
Cdd:PRK09647  48 LSGNQHDAEDLTQETFIRVfrsLQNYQPGTFEGWL-HRITTNLFLDMVRRRA---RIRmealpedyDRVPGDEPNPeqiy 123
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664 102 NIADLHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLK 161
Cdd:PRK09647 124 HDARLDPDLQAALDSLPPEFRAAVVLCDIEGLSYEEIAATLGVKLGTVRSRIHRGRQQLR 183
PRK09652 PRK09652
RNA polymerase sigma factor RpoE; Provisional
30-161 1.73e-05

RNA polymerase sigma factor RpoE; Provisional


Pssm-ID: 236608 [Multi-domain]  Cd Length: 182  Bit Score: 44.03  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  30 LKRYCTFLTKNKWDGEDLAQETVCKVLQK---YRNKEICMTLVYKIARNRWLDQMKSKS---------VHEKIREQITFE 97
Cdd:PRK09652  23 VKRLLSRLTRDPADAEDLVQETFIKAYRAlhsFRGGAAFYTWLYRIARNTAINYLRKQGrrppasdvdAEEAEDFDLADA 102
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446259664  98 EPHENIAD-------LHEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLK 161
Cdd:PRK09652 103 LRDISTPEnellsaeLEQRVRAAIESLPEELRTAITLREIEGLSYEEIAEIMGCPIGTVRSRIFRAREALR 173
PRK09648 PRK09648
RNA polymerase sigma factor ShbA;
45-165 2.00e-05

RNA polymerase sigma factor ShbA;


Pssm-ID: 236607 [Multi-domain]  Cd Length: 189  Bit Score: 43.80  E-value: 2.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  45 EDLAQEtVC----KVLQKYRNK-EICMTLVYKIARNRWLD----QMKSKS-----VHEKIREQITFEEpHENIADLHEMV 110
Cdd:PRK09648  56 DDVAQE-VClaviTALPRYRDQgRPFLAFVYGIAAHKVADahraAGRDKAvpteeVPERPSDDAGPEE-RALRSESSNRM 133
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446259664 111 GKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLKTVSE 165
Cdd:PRK09648 134 RELLDTLPEKQREILILRVVVGLSAEETAEAVGSTPGAVRVAQHRALARLRAEIE 188
Sigma70_r2 pfam04542
Sigma-70 region 2; Region 2 of sigma-70 is the most conserved region of the entire protein. ...
23-85 4.94e-05

Sigma-70 region 2; Region 2 of sigma-70 is the most conserved region of the entire protein. All members of this class of sigma-factor contain region 2. The high conservation is due to region 2 containing both the -10 promoter recognition helix and the primary core RNA polymerase binding determinant. The core binding helix, interacts with the clamp domain of the largest polymerase subunit, beta prime. The aromatic residues of the recognition helix, found at the C-terminus of this domain are though to mediate strand separation, thereby allowing transcription initiation.


Pssm-ID: 427998 [Multi-domain]  Cd Length: 71  Bit Score: 40.26  E-value: 4.94e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446259664   23 LIEQYG-ELKRYCTFLTKNKWDGEDLAQETVCKVLQ---KYRNKEICM--TLVYKIARNRWLDQMKSKS 85
Cdd:pfam04542   1 LVERYLpLVYSLARRYLGDGADAEDLVQEGFLGLWRaieRFDPERGVSfsTWLYTIIRNAIIDYLRKQR 69
PRK08241 PRK08241
RNA polymerase subunit sigma-70;
23-167 8.61e-05

RNA polymerase subunit sigma-70;


Pssm-ID: 236196 [Multi-domain]  Cd Length: 339  Bit Score: 42.62  E-value: 8.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  23 LIEQY-GELKRYCTFLTKNKWDGEDLAQETVCKV---LQKYRNKEICMTLVYKIARNRWLDQMKSKS------------- 85
Cdd:PRK08241  24 LVEPHrRELLAHCYRMLGSVHDAEDAVQETLLRAwrgYDRFEGRSSLRTWLYRIATNVCLDALEGRArrplptdlgapaa 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  86 ---VHEKIREQITFEEPH------ENIADLHEMVGK----------VLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSE 146
Cdd:PRK08241 104 dpvDELVERPEVPWLEPYpdalldPAAADPAARVVAresvrlafvaALQHLPPRQRAVLILRDVLGWSAAEVAELLDTSV 183
                        170       180
                 ....*....|....*....|.
gi 446259664 147 GAVKASLFRSRNRLKTVSEEG 167
Cdd:PRK08241 184 AAVNSALQRARATLAERGPSA 204
PRK09649 PRK09649
RNA polymerase sigma factor SigC; Reviewed
32-160 2.32e-04

RNA polymerase sigma factor SigC; Reviewed


Pssm-ID: 137458 [Multi-domain]  Cd Length: 185  Bit Score: 40.79  E-value: 2.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  32 RYCTFLTkNKWDGEDLAQETVCKVL---QKYRNKEICMTLVYKIARNRWLD-----QMKSKSVHEKIREQITFEEPH-EN 102
Cdd:PRK09649  39 RFVAYLS-DVGSADDLTQETFLRAIgaiPRFSARSSARTWLLAIARHVVADhirhvRSRPRTTRGARPEHLIDGDRHaRG 117
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446259664 103 IADLHEmVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRL 160
Cdd:PRK09649 118 FEDLVE-VTTMIADLTTDQREALLLTQLLGLSYADAAAVCGCPVGTIRSRVARARDAL 174
PRK12516 PRK12516
RNA polymerase sigma factor; Provisional
45-163 7.08e-04

RNA polymerase sigma factor; Provisional


Pssm-ID: 183568 [Multi-domain]  Cd Length: 187  Bit Score: 39.18  E-value: 7.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  45 EDLAQETVCKVLQKYRNKEICMTL---VYKIARNRWLDQMKS--KSVHEK---IREQITFEEPHENIADLHEMvGKVLSS 116
Cdd:PRK12516  38 DDLVQDTIMKAWAKQDHFEVGTNMkawLFTILRNEFYSQMRKrgREVQDTdgmFTEQLAVHPSQYGTLDLQDF-RAALDQ 116
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446259664 117 LNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLKTV 163
Cdd:PRK12516 117 LPDDQREAIILVGASGFAYEEAAEICGCAVGTIKSRVNRARQRLQEI 163
Sigma70_r4 cd06171
Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in ...
107-161 1.83e-03

Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or plastid core RNA polymerase to specific promoter elements located upstream of transcription initiation points. The SR4 of Ec sigma70 and other essential primary SFs contact promoter sequences located 35 base-pairs upstream of the initiation point, recognizing a 6-base-pair -35 consensus TTGACA. Sigma70 related SFs also include SFs which are dispensable for bacterial cell growth for example Ec sigmaS, SFs which activate regulons in response to a specific signal for example heat-shock Ec sigmaH, and a group of SFs which includes the extracytoplasmic function (ECF) SFs and is typified by Ec sigmaE which contains SR2 and -4 only. ECF SFs direct the transcription of genes that regulate various responses including periplasmic stress and pathogenesis. Ec sigmaE SR4 also contacts the -35 element, but recognizes a different consensus (a 7-base-pair GGAACTT). Plant SFs recognize sigma70 type promoters and direct transcription of the major plastid RNA polymerase, plastid-encoded RNA polymerase (PEP).


Pssm-ID: 100119 [Multi-domain]  Cd Length: 55  Bit Score: 35.54  E-value: 1.83e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446259664 107 HEMVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLK 161
Cdd:cd06171    1 RERLEEALDKLPEREREVILLRFGEGLSYEEIAEILGISRSTVRQRLHRALKKLR 55
PRK12512 PRK12512
RNA polymerase sigma factor; Provisional
43-160 1.84e-03

RNA polymerase sigma factor; Provisional


Pssm-ID: 171551 [Multi-domain]  Cd Length: 184  Bit Score: 38.14  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  43 DGEDLAQETVCKVLQK---YRNKEICMTLVYKIARNRWLDQMKSKSVH-----EKIREQITFEEPHENIADLHemVGKVL 114
Cdd:PRK12512  52 QAEDIVQEILLAVHLKrhtWDPGAPFAPWLFAIARNKLIDALRRRGRRvfvdiDDFAETLPAEPATETLPAGD--VGRHL 129
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446259664 115 SSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRL 160
Cdd:PRK12512 130 ETLPPRQRDVVQSISVEGASIKETAAKLSMSEGAVRVALHRGLAAL 175
PRK12511 PRK12511
RNA polymerase sigma factor; Provisional
23-167 2.26e-03

RNA polymerase sigma factor; Provisional


Pssm-ID: 237123 [Multi-domain]  Cd Length: 182  Bit Score: 37.84  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446259664  23 LIEQYGELKRYCTFLTKNKWDGEDLAQETVCKVLQK---YRNKEICMTLVYKIARNRWLDQMKSKSVHEKIREQITFEE- 98
Cdd:PRK12511  10 VLDQLVPLRRYARSLTRDSAEAEDLVHDALVRALERrasFRSGGNLRTWLMSILHNAFIDELRRRRVEARRADELAVLAd 89
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446259664  99 -----PHENIADLHEmVGKVLSSLNVQQSAILLLKDVFQYSIADIAKVCSVSEGAVKASLFRSRNRLKTVsEEG 167
Cdd:PRK12511  90 aslpaAQEHAVRLAQ-IRDAFFDLPEEQRAALHLVAIEGLSYQEAAAVLGIPIGTLMSRIGRARAALRAF-EEG 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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