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Conserved domains on  [gi|446264590|ref|WP_000342445|]
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SecY-interacting protein [Escherichia coli]

Protein Classification

SecY-interacting protein Syd( domain architecture ID 10012237)

SecY-interacting protein Syd binds preferentially to an uncomplexed state of SecY, functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK04968 PRK04968
SecY interacting protein Syd; Provisional
5-181 1.70e-116

SecY interacting protein Syd; Provisional


:

Pssm-ID: 235324  Cd Length: 181  Bit Score: 327.61  E-value: 1.70e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590   5 TARALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQ 84
Cdd:PRK04968   3 VAQALDDFTQRYCDAWQEEHGELPRSEELYGVPSPCIIETSEDAVYWQPQPFEPEGNFNNVERALEITLHPDIHAFYTTQ 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590  85 FAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRT 164
Cdd:PRK04968  83 FAGDMTAQFGGGELTLLQVWSEDDFERLQENLIGHLVMQKRLKLPPTLFIATTDEEDEVISVCNLSGEVILETLGTRKRT 162
                        170
                 ....*....|....*..
gi 446264590 165 HLASNLAEFLNQLKPLL 181
Cdd:PRK04968 163 VLAPSLAEFLNQLEPLL 179
 
Name Accession Description Interval E-value
PRK04968 PRK04968
SecY interacting protein Syd; Provisional
5-181 1.70e-116

SecY interacting protein Syd; Provisional


Pssm-ID: 235324  Cd Length: 181  Bit Score: 327.61  E-value: 1.70e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590   5 TARALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQ 84
Cdd:PRK04968   3 VAQALDDFTQRYCDAWQEEHGELPRSEELYGVPSPCIIETSEDAVYWQPQPFEPEGNFNNVERALEITLHPDIHAFYTTQ 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590  85 FAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRT 164
Cdd:PRK04968  83 FAGDMTAQFGGGELTLLQVWSEDDFERLQENLIGHLVMQKRLKLPPTLFIATTDEEDEVISVCNLSGEVILETLGTRKRT 162
                        170
                 ....*....|....*..
gi 446264590 165 HLASNLAEFLNQLKPLL 181
Cdd:PRK04968 163 VLAPSLAEFLNQLEPLL 179
Syd pfam07348
Syd protein (SUKH-2); This family contains a number of bacterial Syd proteins approximately ...
8-179 8.55e-100

Syd protein (SUKH-2); This family contains a number of bacterial Syd proteins approximately 180 residues long. It has been suggested that Syd is loosely associated with the cytoplasmic surface of the cytoplasmic membrane, and that interaction with SecY may be involved in this membrane association. Operon analysis showed that Syd protein may function as immunity protein in bacterial toxin systems.


Pssm-ID: 429420  Cd Length: 174  Bit Score: 285.26  E-value: 8.55e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590    8 ALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTED-AVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFA 86
Cdd:pfam07348   2 ALSAFTQRYVQLWQQETGELPRSEYLEGWPSPCILGTGDEgAVYWQPVPREEPADFDNVEKALEITLHPDIHAFYGSQYS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590   87 GDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHL 166
Cdd:pfam07348  82 GDLPASFEGGELELLQVWSEDDFERLQENLIGHLLMQRRLKQPPTLFIATTDDEDRLVSVCNLSGEVWLEQLGKKPREVL 161
                         170
                  ....*....|...
gi 446264590  167 ASNLAEFLNQLKP 179
Cdd:pfam07348 162 ADSLAEFLQQLEP 174
Syd cd16323
Syd, a SecY-interacting protein; This family contains the Syd protein that has been implicated ...
7-177 4.61e-82

Syd, a SecY-interacting protein; This family contains the Syd protein that has been implicated in the Sec-dependent transport of polypeptides across the inner membrane in bacteria. Syd has been shown to bind the SecY subunit of membrane-embedded SecYEG heterotrimer (also known as core translocon or SecY complex) which is a conserved protein-conducting channel essential for the biogenesis of most of the secretory and integral membrane proteins. The SecY-binding site of Syd is a conserved concave and electronegative groove that forms interactions with the electropositive loops of the SecY subunit. Syd is also known to verify the proper assembly of the SecY complex in the membrane by interfering with protein translocation only when the channel displays abnormal SecY-SecE associations. Operon analysis has shown that Syd protein may function as immunity protein in bacterial toxin systems.


Pssm-ID: 319993  Cd Length: 173  Bit Score: 240.11  E-value: 4.61e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590   7 RALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTED-AVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQF 85
Cdd:cd16323    2 QALEQFFERYIQAWQEQLGSLPKTEYDEEWPSPCEGEEDEEgYVYWQPVEREPPADFSNLEQALEITLHPDIKAFYGSYY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590  86 AGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTH 165
Cdd:cd16323   82 AGDLPATFQGGELELLQVWNEDDFERLQQNLIGHLLMKRRLKQPPTLFIGLTDDDDLLISVDNETGEVWLEDVGKEPHEV 161
                        170
                 ....*....|..
gi 446264590 166 LASNLAEFLNQL 177
Cdd:cd16323  162 LADSLAEFLSQL 173
 
Name Accession Description Interval E-value
PRK04968 PRK04968
SecY interacting protein Syd; Provisional
5-181 1.70e-116

SecY interacting protein Syd; Provisional


Pssm-ID: 235324  Cd Length: 181  Bit Score: 327.61  E-value: 1.70e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590   5 TARALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQ 84
Cdd:PRK04968   3 VAQALDDFTQRYCDAWQEEHGELPRSEELYGVPSPCIIETSEDAVYWQPQPFEPEGNFNNVERALEITLHPDIHAFYTTQ 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590  85 FAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRT 164
Cdd:PRK04968  83 FAGDMTAQFGGGELTLLQVWSEDDFERLQENLIGHLVMQKRLKLPPTLFIATTDEEDEVISVCNLSGEVILETLGTRKRT 162
                        170
                 ....*....|....*..
gi 446264590 165 HLASNLAEFLNQLKPLL 181
Cdd:PRK04968 163 VLAPSLAEFLNQLEPLL 179
Syd pfam07348
Syd protein (SUKH-2); This family contains a number of bacterial Syd proteins approximately ...
8-179 8.55e-100

Syd protein (SUKH-2); This family contains a number of bacterial Syd proteins approximately 180 residues long. It has been suggested that Syd is loosely associated with the cytoplasmic surface of the cytoplasmic membrane, and that interaction with SecY may be involved in this membrane association. Operon analysis showed that Syd protein may function as immunity protein in bacterial toxin systems.


Pssm-ID: 429420  Cd Length: 174  Bit Score: 285.26  E-value: 8.55e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590    8 ALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTED-AVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFA 86
Cdd:pfam07348   2 ALSAFTQRYVQLWQQETGELPRSEYLEGWPSPCILGTGDEgAVYWQPVPREEPADFDNVEKALEITLHPDIHAFYGSQYS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590   87 GDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHL 166
Cdd:pfam07348  82 GDLPASFEGGELELLQVWSEDDFERLQENLIGHLLMQRRLKQPPTLFIATTDDEDRLVSVCNLSGEVWLEQLGKKPREVL 161
                         170
                  ....*....|...
gi 446264590  167 ASNLAEFLNQLKP 179
Cdd:pfam07348 162 ADSLAEFLQQLEP 174
Syd cd16323
Syd, a SecY-interacting protein; This family contains the Syd protein that has been implicated ...
7-177 4.61e-82

Syd, a SecY-interacting protein; This family contains the Syd protein that has been implicated in the Sec-dependent transport of polypeptides across the inner membrane in bacteria. Syd has been shown to bind the SecY subunit of membrane-embedded SecYEG heterotrimer (also known as core translocon or SecY complex) which is a conserved protein-conducting channel essential for the biogenesis of most of the secretory and integral membrane proteins. The SecY-binding site of Syd is a conserved concave and electronegative groove that forms interactions with the electropositive loops of the SecY subunit. Syd is also known to verify the proper assembly of the SecY complex in the membrane by interfering with protein translocation only when the channel displays abnormal SecY-SecE associations. Operon analysis has shown that Syd protein may function as immunity protein in bacterial toxin systems.


Pssm-ID: 319993  Cd Length: 173  Bit Score: 240.11  E-value: 4.61e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590   7 RALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTED-AVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQF 85
Cdd:cd16323    2 QALEQFFERYIQAWQEQLGSLPKTEYDEEWPSPCEGEEDEEgYVYWQPVEREPPADFSNLEQALEITLHPDIKAFYGSYY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446264590  86 AGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTH 165
Cdd:cd16323   82 AGDLPATFQGGELELLQVWNEDDFERLQQNLIGHLLMKRRLKQPPTLFIGLTDDDDLLISVDNETGEVWLEDVGKEPHEV 161
                        170
                 ....*....|..
gi 446264590 166 LASNLAEFLNQL 177
Cdd:cd16323  162 LADSLAEFLSQL 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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