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Conserved domains on  [gi|446265821|ref|WP_000343676|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Bacillus]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-136 1.22e-29

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 104.28  E-value: 1.22e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821   5 QHFFHIVSQTSRKFTKKFNERVSPTGLFSAQWAVIFRINQTGSCTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEG-K 83
Cdd:COG1846   10 ERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDpE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446265821  84 DRREKLISLSETAIKMIPVWQEEVDTFEEKTLDGINEDDLHQAFQVLQQIIKN 136
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-136 1.22e-29

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 104.28  E-value: 1.22e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821   5 QHFFHIVSQTSRKFTKKFNERVSPTGLFSAQWAVIFRINQTGSCTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEG-K 83
Cdd:COG1846   10 ERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDpE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446265821  84 DRREKLISLSETAIKMIPVWQEEVDTFEEKTLDGINEDDLHQAFQVLQQIIKN 136
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
24-123 5.75e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 81.10  E-value: 5.75e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821    24 ERVSPTGLFSAQWAVIFRINQTGSCTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEG-KDRREKLISLSETAIKMIPV 102
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSpEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 446265821   103 WQEEVDTFEEKTLDGINEDDL 123
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-87 7.13e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 54.13  E-value: 7.13e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821   29 TGLFSAQWAVIFRINQTGSCTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEGK-DRRE 87
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPaDRRA 60
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 23-136 2.11e-09

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 52.31  E-value: 2.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821  23 NERVSPTGLFSAQWAVIFRINQTG-SCTQTELCQYLNVESPTMTRTLTRMETMGWIIR-TEGKDRREKLISLSETAIKMI 100
Cdd:PRK03573  21 DHRLKPLELTQTHWVTLHNIHQLPpEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRqTCASDRRAKRIKLTEKAEPLI 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446265821 101 pvwqEEVDTFEEKT----LDGINEDDLHQAFQVLQQIIKN 136
Cdd:PRK03573 101 ----SEVEAVINKTraeiLHGISAEEIEQLITLIAKLEKN 136
HpaR TIGR02337
homoprotocatechuate degradation operon regulator, HpaR; This Helix-Turn-Helix transcriptional ...
 30-108 1.55e-07

homoprotocatechuate degradation operon regulator, HpaR; This Helix-Turn-Helix transcriptional regulator is a member of the MarR family (pfam01047) and is found in association with operons for the degradation of 4-hydroxyphenylacetic acid via homoprotocatechuate.


Pssm-ID: 188209 [Multi-domain]  Cd Length: 118  Bit Score: 46.61  E-value: 1.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821   30 GLFSAQWAVIFRINQTGSCTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEGK-DRREKLISLSETAIKMIPVWQEEVD 108
Cdd:TIGR02337  25 GLTEQQWRILRILAEQGSMEFTQLANQACILRPSLTGILARLERDGLVTRLKASnDQRRVYISLTPKGQALYASLSPQIE 104
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-136 1.22e-29

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 104.28  E-value: 1.22e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821   5 QHFFHIVSQTSRKFTKKFNERVSPTGLFSAQWAVIFRINQTGSCTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEG-K 83
Cdd:COG1846   10 ERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDpE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446265821  84 DRREKLISLSETAIKMIPVWQEEVDTFEEKTLDGINEDDLHQAFQVLQQIIKN 136
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
24-123 5.75e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 81.10  E-value: 5.75e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821    24 ERVSPTGLFSAQWAVIFRINQTGSCTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEG-KDRREKLISLSETAIKMIPV 102
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSpEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 446265821   103 WQEEVDTFEEKTLDGINEDDL 123
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-87 7.13e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 54.13  E-value: 7.13e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821   29 TGLFSAQWAVIFRINQTGSCTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEGK-DRRE 87
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPaDRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 34-88 2.44e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 52.55  E-value: 2.44e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 446265821   34 AQWAVIFRINQTGSCTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEGK-DRREK 88
Cdd:pfam01047   4 TQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPeDRREV 59
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 23-136 2.11e-09

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 52.31  E-value: 2.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821  23 NERVSPTGLFSAQWAVIFRINQTG-SCTQTELCQYLNVESPTMTRTLTRMETMGWIIR-TEGKDRREKLISLSETAIKMI 100
Cdd:PRK03573  21 DHRLKPLELTQTHWVTLHNIHQLPpEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRqTCASDRRAKRIKLTEKAEPLI 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446265821 101 pvwqEEVDTFEEKT----LDGINEDDLHQAFQVLQQIIKN 136
Cdd:PRK03573 101 ----SEVEAVINKTraeiLHGISAEEIEQLITLIAKLEKN 136
HpaR TIGR02337
homoprotocatechuate degradation operon regulator, HpaR; This Helix-Turn-Helix transcriptional ...
 30-108 1.55e-07

homoprotocatechuate degradation operon regulator, HpaR; This Helix-Turn-Helix transcriptional regulator is a member of the MarR family (pfam01047) and is found in association with operons for the degradation of 4-hydroxyphenylacetic acid via homoprotocatechuate.


Pssm-ID: 188209 [Multi-domain]  Cd Length: 118  Bit Score: 46.61  E-value: 1.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821   30 GLFSAQWAVIFRINQTGSCTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEGK-DRREKLISLSETAIKMIPVWQEEVD 108
Cdd:TIGR02337  25 GLTEQQWRILRILAEQGSMEFTQLANQACILRPSLTGILARLERDGLVTRLKASnDQRRVYISLTPKGQALYASLSPQIE 104
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
9-94 1.58e-06

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 44.50  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821   9 HIVSQtsrKFTKKFNERVSPTGLFSAQWAVIFRINQTGSCTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEG-KDRRE 87
Cdd:PRK11512  19 HMVNQ---KKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNpNDKRG 95


                 ....*..
gi 446265821  88 KLISLSE 94
Cdd:PRK11512  96 VLVKLTT 102
HTH_27 pfam13463
Winged helix DNA-binding domain;
35-94 2.15e-06

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 42.66  E-value: 2.15e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446265821   35 QWAVIFRINQTGS-CTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEG-KDRREKLISLSE 94
Cdd:pfam13463   5 EALILHNIGHRGDpKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSeEDGRETRVRLTA 66
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
46-137 5.82e-05

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 41.03  E-value: 5.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446265821  46 GSCTQTELCQYLNVESPTMTRTLTRMETMGWIIRTEGK-----------DRREKLISLSETAIKMIPVWQE-EVDTFEEK 113
Cdd:COG4742   28 GPKTRSELAESLDVSRSTILRQLKELEERGLIERDDGEyelttlgrlvvEEMEPLLDTLEVLEENRDYWEThDLSAIPPE 107

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446265821 114 TLDGINE--------DDLHQAFQVLQQIIKNL 137
Cdd:COG4742  108 LLLRIGElgdatviePDLTDPFEPVERFLELL 139
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 49-102 1.05e-04

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 40.28  E-value: 1.05e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446265821  49 TQTELCQYLNVESPTMTRTLTRMETMGWIIRTEGKDRREKLISLSEtAIKMIPV 102
Cdd:COG1974   27 SQREIAEALGLSSSAVHRHLKALEKKGYLRRDPGKSRAIELLPASP-EVVGLPL 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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