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Conserved domains on  [gi|446271630|ref|WP_000349485|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Bacteria]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-91 2.24e-17

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 70.30  E-value: 2.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446271630   1 MDHEKVAASLAE----LGNSHRLSVFRFLVkagHDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSRTIVCIPE 76
Cdd:COG0640    1 MSETKELEELAElfkaLADPTRLRILRLLA---EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77

                         90
                 ....*....|....*
gi 446271630  77 YGHLENLIGFLQEEC 91
Cdd:COG0640   78 DEALAELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-91 2.24e-17

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 70.30  E-value: 2.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446271630   1 MDHEKVAASLAE----LGNSHRLSVFRFLVkagHDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSRTIVCIPE 76
Cdd:COG0640    1 MSETKELEELAElfkaLADPTRLRILRLLA---EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77

                         90
                 ....*....|....*
gi 446271630  77 YGHLENLIGFLQEEC 91
Cdd:COG0640   78 DEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-84 6.58e-12

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 55.93  E-value: 6.58e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446271630   6 VAASLAELGNSHRLSVFRFLVKaghDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSRTIVCIPEYGHLENLI 84
Cdd:NF033788   1 LAELFKALADPTRLRILELLAE---GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 10-69 1.33e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 54.85  E-value: 1.33e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446271630   10 LAELGNSHRLSVFRFLVkaGHDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSR 69
Cdd:pfam12840   4 AEALADPTRLRILRALV--GDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-89 1.41e-11

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 55.38  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446271630  10 LAELGNSHRLSVFRFLVKaghDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSRTI-VCIPEYGHLENLIGFLQ 88
Cdd:cd00090    1 LKALSDPTRLRILRLLLE---GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVyYSLTDAERLLALLESLL 77


                 .
gi 446271630  89 E 89
Cdd:cd00090   78 E 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-88 8.42e-10

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 50.29  E-value: 8.42e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 446271630    30 HDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSRTIVCIPEYGHLENLIGFLQ 88
Cdd:smart00418   8 EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-91 2.24e-17

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 70.30  E-value: 2.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446271630   1 MDHEKVAASLAE----LGNSHRLSVFRFLVkagHDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSRTIVCIPE 76
Cdd:COG0640    1 MSETKELEELAElfkaLADPTRLRILRLLA---EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77

                         90
                 ....*....|....*
gi 446271630  77 YGHLENLIGFLQEEC 91
Cdd:COG0640   78 DEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-84 6.58e-12

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 55.93  E-value: 6.58e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446271630   6 VAASLAELGNSHRLSVFRFLVKaghDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSRTIVCIPEYGHLENLI 84
Cdd:NF033788   1 LAELFKALADPTRLRILELLAE---GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 10-69 1.33e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 54.85  E-value: 1.33e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446271630   10 LAELGNSHRLSVFRFLVkaGHDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSR 69
Cdd:pfam12840   4 AEALADPTRLRILRALV--GDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-89 1.41e-11

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 55.38  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446271630  10 LAELGNSHRLSVFRFLVKaghDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSRTI-VCIPEYGHLENLIGFLQ 88
Cdd:cd00090    1 LKALSDPTRLRILRLLLE---GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVyYSLTDAERLLALLESLL 77


                 .
gi 446271630  89 E 89
Cdd:cd00090   78 E 78
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
1-81 9.58e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 53.43  E-value: 9.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446271630   1 MDHEKVAASLAELGNSHRLSVFRFLVKaghDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQE----KHSRTIVCIPE 76
Cdd:COG4189    4 LDDEESLEVLKALASETRLRILRLLAE---EPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEykpgKRGRQKICYLR 80


                 ....*
gi 446271630  77 YGHLE 81
Cdd:COG4189   81 VDKIL 85
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-88 8.42e-10

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 50.29  E-value: 8.42e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 446271630    30 HDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSRTIVCIPEYGHLENLIGFLQ 88
Cdd:smart00418   8 EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 1-81 1.43e-06

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 42.21  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446271630   1 MDHEKVAASLAELGNSHRlSVFRFLVKAGhDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSRT-IVCIPEYGH 79
Cdd:COG2512    1 MLVVAALLLYPELLEDER-RVLELLRENG-GRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGREnVVELPEDEP 78


                 ..
gi 446271630  80 LE 81
Cdd:COG2512   79 EA 80
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
2-72 1.30e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 41.40  E-value: 1.30e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446271630   2 DHEKVAASLaeLGNSHRLSVFRFLVKagHDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSRTIV 72
Cdd:COG3398   85 EEEKKILAY--LRRETPRRILLYLLE--NPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVR 151
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
13-90 2.83e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 40.25  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446271630  13 LGNSHRLSVFRFLVKagHDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSRTIVCIP---EYGHLE-NLIGFLQ 88
Cdd:COG3398   18 LDNDTRRRIYEYIRE--NPGIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDGGRTRYFPnsgTYSEEEkKILAYLR 95


                 ..
gi 446271630  89 EE 90
Cdd:COG3398   96 RE 97
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 21-65 1.05e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 37.18  E-value: 1.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 446271630   21 VFRFLvkAGHDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQE 65
Cdd:pfam12802  10 VLLAL--ARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVERE 52
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
1-69 1.05e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 38.09  E-value: 1.05e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446271630   1 MDHEKVAASLAELGNSHRLSVFRFLVKAGHdgaSVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSR 69
Cdd:COG1777    2 SDDEDLDRLLDALGNPTRRRILALLSEEPA---YVSELARELGVSRQAVYKHLRKLEEAGLVESYREGR 67
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-67 2.16e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 37.64  E-value: 2.16e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446271630   3 HEKVAASLAELGNSH-RLSVFRFLvkAGHDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKH 67
Cdd:COG1846   24 RRALDRALAELGLTPaQFRVLAAL--AEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPD 87
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
30-69 4.66e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 36.42  E-value: 4.66e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 446271630    30 HDGASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKHSR 69
Cdd:smart00347  22 EGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPE 61
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 34-62 7.56e-04

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 34.34  E-value: 7.56e-04
                          10        20
                  ....*....|....*....|....*....
gi 446271630   34 SVGDIQKGLGIPASTLSHHLARMAKVGLI 62
Cdd:pfam01022  17 CVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
1-67 7.91e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 36.80  E-value: 7.91e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446271630   1 MDHEKVAASLAELGNSHRLSVFRFLVkaghDG-ASVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKH 67
Cdd:COG4742    1 MGSMKLDLLDFLFLSEKRKNILLLLA----EGpKTRSELAESLDVSRSTILRQLKELEERGLIERDDG 64
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 34-75 4.60e-03

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 34.51  E-value: 4.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 446271630  34 SVGDIQKGLGIPASTLSHHLARMAKVGLIRQEKH-SRTIVCIP 75
Cdd:COG1974   27 SQREIAEALGLSSSAVHRHLKALEKKGYLRRDPGkSRAIELLP 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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