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Conserved domains on  [gi|446272952|ref|WP_000350807|]
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MULTISPECIES: LysR family transcriptional regulator [Enterobacteriaceae]

Protein Classification

LysR family transcriptional regulator( domain architecture ID 11426483)

LysR family transcriptional regulator containing an N-terminal HTH (helix-turn-helix) DNA-binding domain and a C-terminal substrate binding domain, which is structurally homologous to the type 2 periplasmic-binding (PBP2) fold proteins

CATH:  3.40.190.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
SCOP:  4000316

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
1-291 2.63e-20

DNA-binding transcriptional regulator, LysR family [Transcription];


:

Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 87.61  E-value: 2.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   1 MDIfisKKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQKLFPVYQRLSA 80
Cdd:COG0583    1 MDL---RQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRILAELEE 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952  81 IDNEIHN-SGRRSREIVIGIDNTYPTIIFDQLIS-LGDKYEGVTAQPVEFSENGVIDNLFDRQLDFIIspqhvSARVQEL 158
Cdd:COG0583   78 AEAELRAlRGGPRGTLRIGAPPSLARYLLPPLLArFRARHPGVRLELREGNSDRLVDALLEGELDLAI-----RLGPPPD 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952 159 ENLTISELPPLRLGFLVSRRYEERQEQELLQelpwlqmrfqnranfeamidanmrpcginptiiyrpySFMAKISAVERG 238
Cdd:COG0583  153 PGLVARPLGEERLVLVASPDHPLARRAPLVN-------------------------------------SLEALLAAVAAG 195
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446272952 239 HFLTVIPHF-AWRLVNPATLKYFDAPHRPMYMQEYLYSIRNHRYTATM---LQHIAE 291
Cdd:COG0583  196 LGIALLPRFlAADELAAGRLVALPLPDPPPPRPLYLVWRRRRHLSPAVrafLDFLRE 252
 
Name Accession Description Interval E-value
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
1-291 2.63e-20

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 87.61  E-value: 2.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   1 MDIfisKKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQKLFPVYQRLSA 80
Cdd:COG0583    1 MDL---RQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRILAELEE 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952  81 IDNEIHN-SGRRSREIVIGIDNTYPTIIFDQLIS-LGDKYEGVTAQPVEFSENGVIDNLFDRQLDFIIspqhvSARVQEL 158
Cdd:COG0583   78 AEAELRAlRGGPRGTLRIGAPPSLARYLLPPLLArFRARHPGVRLELREGNSDRLVDALLEGELDLAI-----RLGPPPD 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952 159 ENLTISELPPLRLGFLVSRRYEERQEQELLQelpwlqmrfqnranfeamidanmrpcginptiiyrpySFMAKISAVERG 238
Cdd:COG0583  153 PGLVARPLGEERLVLVASPDHPLARRAPLVN-------------------------------------SLEALLAAVAAG 195
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446272952 239 HFLTVIPHF-AWRLVNPATLKYFDAPHRPMYMQEYLYSIRNHRYTATM---LQHIAE 291
Cdd:COG0583  196 LGIALLPRFlAADELAAGRLVALPLPDPPPPRPLYLVWRRRRHLSPAVrafLDFLRE 252
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
7-65 1.41e-12

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 61.25  E-value: 1.41e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446272952    7 KKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQ 65
Cdd:pfam00126   2 RQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAGE 60
PRK15243 PRK15243
virulence genes transcriptional activator SpvR;
1-113 1.99e-10

virulence genes transcriptional activator SpvR;


Pssm-ID: 185155 [Multi-domain]  Cd Length: 297  Bit Score: 60.45  E-value: 1.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   1 MDIFISKKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQKLFPVYQRLSA 80
Cdd:PRK15243   1 MDFLINKKLKIFITLMETGSFSIATSVLYITRTPLSRVISDLERELKQRLFIRKNGTLIPTEFAQTIYRKVKSHYIFLHA 80
                         90       100       110
                 ....*....|....*....|....*....|...
gi 446272952  81 IDNEIHNSGrRSREIVIGIDNTYPTIIFDQLIS 113
Cdd:PRK15243  81 LEQEIGPTG-KTKQLEIIFDEIYPESLKNLIIS 112
PBP2_LTTR_substrate cd05466
The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the ...
94-281 6.25e-07

The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; This model and hierarchy represent the the substrate-binding domain of the LysR-type transcriptional regulators that form the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, oxidative stress responses, nodule formation of nitrogen-fixing bacteria, synthesis of virulence factors, toxin production, attachment and secretion, to name a few. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.


Pssm-ID: 176102 [Multi-domain]  Cd Length: 197  Bit Score: 48.75  E-value: 6.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952  94 EIVIGIDNTYPTIIFDQLIS-LGDKYEGVTAQPVEFSENGVIDNLFDRQLDFIISPQHVSArvqelENLTISELPPLRLG 172
Cdd:cd05466    1 TLRIGASPSIAAYLLPPLLAaFRQRYPGVELSLVEGGSSELLEALLEGELDLAIVALPVDD-----PGLESEPLFEEPLV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952 173 FLVSRRYEERQEQEL----LQELPWLqmRFQNRANFEAMIDANMRPCGINPTIIYRPYSFMAKISAVERGHFLTVIPHFA 248
Cdd:cd05466   76 LVVPPDHPLAKRKSVtladLADEPLI--LFERGSGLRRLLDRAFAEAGFTPNIALEVDSLEAIKALVAAGLGIALLPESA 153
                        170       180       190
                 ....*....|....*....|....*....|...
gi 446272952 249 WRLVNPATLKYFDAPHRPMYMQEYLYsIRNHRY 281
Cdd:cd05466  154 VEELADGGLVVLPLEDPPLSRTIGLV-WRKGRY 185
 
Name Accession Description Interval E-value
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
1-291 2.63e-20

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 87.61  E-value: 2.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   1 MDIfisKKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQKLFPVYQRLSA 80
Cdd:COG0583    1 MDL---RQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRILAELEE 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952  81 IDNEIHN-SGRRSREIVIGIDNTYPTIIFDQLIS-LGDKYEGVTAQPVEFSENGVIDNLFDRQLDFIIspqhvSARVQEL 158
Cdd:COG0583   78 AEAELRAlRGGPRGTLRIGAPPSLARYLLPPLLArFRARHPGVRLELREGNSDRLVDALLEGELDLAI-----RLGPPPD 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952 159 ENLTISELPPLRLGFLVSRRYEERQEQELLQelpwlqmrfqnranfeamidanmrpcginptiiyrpySFMAKISAVERG 238
Cdd:COG0583  153 PGLVARPLGEERLVLVASPDHPLARRAPLVN-------------------------------------SLEALLAAVAAG 195
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446272952 239 HFLTVIPHF-AWRLVNPATLKYFDAPHRPMYMQEYLYSIRNHRYTATM---LQHIAE 291
Cdd:COG0583  196 LGIALLPRFlAADELAAGRLVALPLPDPPPPRPLYLVWRRRRHLSPAVrafLDFLRE 252
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
7-65 1.41e-12

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 61.25  E-value: 1.41e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446272952    7 KKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQ 65
Cdd:pfam00126   2 RQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAGE 60
PRK15243 PRK15243
virulence genes transcriptional activator SpvR;
1-113 1.99e-10

virulence genes transcriptional activator SpvR;


Pssm-ID: 185155 [Multi-domain]  Cd Length: 297  Bit Score: 60.45  E-value: 1.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   1 MDIFISKKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQKLFPVYQRLSA 80
Cdd:PRK15243   1 MDFLINKKLKIFITLMETGSFSIATSVLYITRTPLSRVISDLERELKQRLFIRKNGTLIPTEFAQTIYRKVKSHYIFLHA 80
                         90       100       110
                 ....*....|....*....|....*....|...
gi 446272952  81 IDNEIHNSGrRSREIVIGIDNTYPTIIFDQLIS 113
Cdd:PRK15243  81 LEQEIGPTG-KTKQLEIIFDEIYPESLKNLIIS 112
PRK10094 PRK10094
HTH-type transcriptional activator AllS;
9-157 4.13e-08

HTH-type transcriptional activator AllS;


Pssm-ID: 182237 [Multi-domain]  Cd Length: 308  Bit Score: 53.66  E-value: 4.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   9 MRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQKLFPVYQRLSAIDNEIH-- 86
Cdd:PRK10094   7 LRTFIAVAETGSFSKAAERLCKTTATISYRIKLLEENTGVALFFRTTRSVTLTAAGEHLLSQARDWLSWLESMPSELQqv 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952  87 NSGRRsREIVIGIDNTY--PTIIFDQLISLGDKYE---------------------------GVTA-QPVefSENGVIDN 136
Cdd:PRK10094  87 NDGVE-RQVNIVINNLLynPQAVAQLLAWLNERYPftqfhisrqiymgvwdsllyegfslaiGVTGtEAL--ANTFSLDP 163
                        170       180
                 ....*....|....*....|.
gi 446272952 137 LFDRQLDFIISPQHVSARVQE 157
Cdd:PRK10094 164 LGSVQWRFVMAADHPLANVEE 184
LysR_substrate pfam03466
LysR substrate binding domain; The structure of this domain is known and is similar to the ...
92-291 1.24e-07

LysR substrate binding domain; The structure of this domain is known and is similar to the periplasmic binding proteins. This domain binds a variety of ligands that caries in size and structure, such as amino acids, sugar phosphates, organic acids, metal cations, flavonoids, C6-ring carboxylic acids, H2O2, HOCl, homocysteine, NADPH, ATP, sulphate, muropeptides, acetate, salicylate, citrate, phenol- and quinolone derivatives, acetylserines, fatty acid CoA, shikimate, chorismate, homocysteine, indole-3-acetic acid, Na(I), c-di-GMP, ppGpp and hydrogen peroxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460931 [Multi-domain]  Cd Length: 205  Bit Score: 51.14  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   92 SREIVIGIDNTYPTIIFDQLIS-LGDKYEGVTAQPVEFSENGVIDNLFDRQLDFIISpqhvsARVQELENLTISELPPLR 170
Cdd:pfam03466   1 SGRLRIGAPPTLASYLLPPLLArFRERYPDVELELTEGNSEELLDLLLEGELDLAIR-----RGPPDDPGLEARPLGEEP 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952  171 LGFLVSRRYEERQEQEL----LQELPWLqmRFQNRANFEAMIDANMRPCGINPTIIYRPYSFMAKISAVERGHFLTVIP- 245
Cdd:pfam03466  76 LVLVAPPDHPLARGEPVsledLADEPLI--LLPPGSGLRDLLDRALRAAGLRPRVVLEVNSLEALLQLVAAGLGIALLPr 153
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 446272952  246 HFAWRLVNPATLKYFDAPHRPMYMQEYLYSIRNHR---YTATMLQHIAE 291
Cdd:pfam03466 154 SAVARELADGRLVALPLPEPPLPRELYLVWRKGRPlspAVRAFIEFLRE 202
PBP2_LTTR_substrate cd05466
The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the ...
94-281 6.25e-07

The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; This model and hierarchy represent the the substrate-binding domain of the LysR-type transcriptional regulators that form the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, oxidative stress responses, nodule formation of nitrogen-fixing bacteria, synthesis of virulence factors, toxin production, attachment and secretion, to name a few. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.


Pssm-ID: 176102 [Multi-domain]  Cd Length: 197  Bit Score: 48.75  E-value: 6.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952  94 EIVIGIDNTYPTIIFDQLIS-LGDKYEGVTAQPVEFSENGVIDNLFDRQLDFIISPQHVSArvqelENLTISELPPLRLG 172
Cdd:cd05466    1 TLRIGASPSIAAYLLPPLLAaFRQRYPGVELSLVEGGSSELLEALLEGELDLAIVALPVDD-----PGLESEPLFEEPLV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952 173 FLVSRRYEERQEQEL----LQELPWLqmRFQNRANFEAMIDANMRPCGINPTIIYRPYSFMAKISAVERGHFLTVIPHFA 248
Cdd:cd05466   76 LVVPPDHPLAKRKSVtladLADEPLI--LFERGSGLRRLLDRAFAEAGFTPNIALEVDSLEAIKALVAAGLGIALLPESA 153
                        170       180       190
                 ....*....|....*....|....*....|...
gi 446272952 249 WRLVNPATLKYFDAPHRPMYMQEYLYsIRNHRY 281
Cdd:cd05466  154 VEELADGGLVVLPLEDPPLSRTIGLV-WRKGRY 185
PRK03601 PRK03601
HTH-type transcriptional regulator HdfR;
9-67 1.10e-06

HTH-type transcriptional regulator HdfR;


Pssm-ID: 235137 [Multi-domain]  Cd Length: 275  Bit Score: 48.86  E-value: 1.10e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446272952   9 MRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQEL 67
Cdd:PRK03601   6 LKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGERL 64
PRK09986 PRK09986
LysR family transcriptional regulator;
5-99 2.60e-06

LysR family transcriptional regulator;


Pssm-ID: 182183 [Multi-domain]  Cd Length: 294  Bit Score: 47.80  E-value: 2.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   5 ISKKM-RNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQKLFPVYQRLSAIDN 83
Cdd:PRK09986   7 IDLKLlRYFLAVAEELHFGRAAARLNISQPPLSIHIKELEDQLGTPLFIRHSRSVVLTHAGKILMEESRRLLDNAEQSLA 86
                         90
                 ....*....|....*..
gi 446272952  84 EIHNSGRRSR-EIVIGI 99
Cdd:PRK09986  87 RVEQIGRGEAgRIEIGI 103
PRK10086 PRK10086
DNA-binding transcriptional regulator DsdC;
8-95 2.86e-05

DNA-binding transcriptional regulator DsdC;


Pssm-ID: 182231 [Multi-domain]  Cd Length: 311  Bit Score: 44.99  E-value: 2.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   8 KMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQKLfpvYQRLSAIDNEIHN 87
Cdd:PRK10086  18 KLHTFEVAARHQSFALAADELSLTPSAVSHRINQLEEELGIKLFVRSHRKVELTEEGKRVFWAL---KSSLDTLNQEILD 94

                 ....*...
gi 446272952  88 sgRRSREI 95
Cdd:PRK10086  95 --IKNQEL 100
PRK13348 PRK13348
HTH-type transcriptional regulator ArgP;
7-71 3.20e-05

HTH-type transcriptional regulator ArgP;


Pssm-ID: 237357 [Multi-domain]  Cd Length: 294  Bit Score: 44.58  E-value: 3.20e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446272952   7 KKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRkDNNISLNKAGQELYQKL 71
Cdd:PRK13348   5 KQLEALAAVVETGSFERAARRLHVTPSAVSQRIKALEESLGQPLLVR-GRPCRPTPAGQRLLRHL 68
PRK09906 PRK09906
DNA-binding transcriptional regulator HcaR; Provisional
7-65 1.23e-04

DNA-binding transcriptional regulator HcaR; Provisional


Pssm-ID: 182137 [Multi-domain]  Cd Length: 296  Bit Score: 42.83  E-value: 1.23e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   7 KKMRNFILLAQTNNIARAAEKIHmTASP-FGKSIAALEEQIGYTLFTRKDNNISLNKAGQ 65
Cdd:PRK09906   4 RHLRYFVAVAEELNFTKAAEKLH-TAQPsLSQQIKDLENCVGVPLLVRDKRKVALTAAGE 62
PRK12680 PRK12680
LysR family transcriptional regulator;
8-137 2.83e-04

LysR family transcriptional regulator;


Pssm-ID: 183677 [Multi-domain]  Cd Length: 327  Bit Score: 41.92  E-value: 2.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   8 KMRNFILLAQTN-NIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNI-SLNKAGQELYQKLFPVYQRLSAIDNEI 85
Cdd:PRK12680   5 QLRYLVAIADAElNITLAAARVHATQPGLSKQLKQLEDELGFLLFVRKGRSLeSVTPAGVEVIERARAVLSEANNIRTYA 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446272952  86 HNSGRRSR-EIVIGIDNTYPTIIFDQLIS-LGDKYEGVTAQPVEFSENGVIDNL 137
Cdd:PRK12680  85 ANQRRESQgQLTLTTTHTQARFVLPPAVAqIKQAYPQVSVHLQQAAESAALDLL 138
PRK11242 PRK11242
DNA-binding transcriptional regulator CynR; Provisional
10-245 3.12e-04

DNA-binding transcriptional regulator CynR; Provisional


Pssm-ID: 183051 [Multi-domain]  Cd Length: 296  Bit Score: 41.48  E-value: 3.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952  10 RNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQKLFPVYQRLSAIDNEIHNSG 89
Cdd:PRK11242   7 RYFLAVAEHGNFTRAAEALHVSQPTLSQQIRQLEESLGVQLFDRSGRTVRLTDAGEVYLRYARRALQDLEAGRRAIHDVA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952  90 RRSR-EIVIGIDNTYPTIIFDQLIS-LGDKYEGVTAQPVEFSENGVIDNLFDRQLDFIISpqHVSARVQELENLTiseLP 167
Cdd:PRK11242  87 DLSRgSLRLAMTPTFTAYLIGPLIDaFHARYPGITLTIREMSQERIEALLADDELDVGIA--FAPVHSPEIEAQP---LF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952 168 PLRLGFLVSR--RYEERQEQ---ELLQELPW--LQMRFQNRANfeamIDANMRPCGINPTIIYRPYSFMAKISAVERGHF 240
Cdd:PRK11242 162 TETLALVVGRhhPLAARRKAltlDELADEPLvlLSAEFATREQ----IDRYFRRHGVTPRVAIEANSISAVLEIVRRGRL 237

                 ....*
gi 446272952 241 LTVIP 245
Cdd:PRK11242 238 ATLLP 242
PRK10082 PRK10082
hypochlorite stress DNA-binding transcriptional regulator HypT;
6-147 5.08e-04

hypochlorite stress DNA-binding transcriptional regulator HypT;


Pssm-ID: 182228 [Multi-domain]  Cd Length: 303  Bit Score: 41.19  E-value: 5.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   6 SKKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQKLFPVYQRLSAIDNEI 85
Cdd:PRK10082  13 TKWLYDFLTLEKCRNFSQAAVSRNVSQPAFSRRIRALEQAIGVELFNRQVTPLQLSEQGKIFHSQIRHLLQQLESNLAEL 92
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446272952  86 H-NSGRRSREIVIGIDNTYPTIIFDQLISLGDKYEGVTAQPVEFSEngVIDNLFDRQLDFIIS 147
Cdd:PRK10082  93 RgGSDYAQRKIKIAAAHSLSLGLLPSIISQMPPLFTWAIEAIDVDE--AVDKLREGQSDCIFS 153
PRK09801 PRK09801
LysR family transcriptional regulator;
5-145 7.43e-04

LysR family transcriptional regulator;


Pssm-ID: 182085 [Multi-domain]  Cd Length: 310  Bit Score: 40.40  E-value: 7.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   5 ISKKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQ---KLFPVYQRLsaI 81
Cdd:PRK09801   7 LAKDLQVLVEIVHSGSFSAAAATLGQTPAFVTKRIQILENTLATTLLNRSARGVALTESGQRCYEhalEILTQYQRL--V 84
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446272952  82 DNEIHNSGRRSREIVIGIDntyptiifdqlISLGDKY--EGVTAQPVEFSENGVIDNLFDRQLDFI 145
Cdd:PRK09801  85 DDVTQIKTRPEGMIRIGCS-----------FGFGRSHiaPAITELMRNYPELQVHFELFDRQIDLV 139
PRK09791 PRK09791
LysR family transcriptional regulator;
8-158 8.73e-04

LysR family transcriptional regulator;


Pssm-ID: 182077 [Multi-domain]  Cd Length: 302  Bit Score: 40.13  E-value: 8.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   8 KMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQKLFPVYQRLSAIDNEIHN 87
Cdd:PRK09791   9 QIRAFVEVARQGSIRGASRMLNMSQPALTKSIQELEEGLAAQLFFRRSKGVTLTDAGESFYQHASLILEELRAAQEDIRQ 88
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446272952  88 S-GRRSREIVIGIDNTYPTIIFDQLIS-LGDKYEGVTAQPVEFSENGVIDNLFDRQLDFIISPQHVSARVQEL 158
Cdd:PRK09791  89 RqGQLAGQINIGMGASIARSLMPAVISrFHQQHPQVKVRIMEGQLVSMINELRQGELDFTINTYYQGPYDHEF 161
PRK10341 PRK10341
transcriptional regulator TdcA;
6-245 1.11e-03

transcriptional regulator TdcA;


Pssm-ID: 182391 [Multi-domain]  Cd Length: 312  Bit Score: 39.85  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952   6 SKKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQKLFPVYQRLSAIDNEI 85
Cdd:PRK10341   9 TQHLVVFQEVIRSGSIGSAAKELGLTQPAVSKIINDIEDYFGVELIVRKNTGVTLTPAGQVLLSRSESITREMKNMVNEI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952  86 HN-SGRRSREIVIGidntYPTII-FDQLISLGDKYEGVTAQP----VEFSENGVIDNLFDRQLDFIISPQHVSARVQEL- 158
Cdd:PRK10341  89 NGmSSEAVVDVSFG----FPSLIgFTFMSDMINKFKEVFPKAqvsmYEAQLSSFLPAIRDGRLDFAIGTLSNEMKLQDLh 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446272952 159 -ENLTISELPplrLGFLVSRRYEERQEQELLQELPWLQMrfQNRANFEAMIDANMRPCGINPTIIYRPYSFMAKISAVER 237
Cdd:PRK10341 165 vEPLFESEFV---LVASKSRTCTGTTTLESLKNEQWVLP--QTNMGYYSELLTTLQRNGISIENIVKTDSVVTIYNLVLN 239

                 ....*...
gi 446272952 238 GHFLTVIP 245
Cdd:PRK10341 240 ADFLTVIP 247
PRK15421 PRK15421
HTH-type transcriptional regulator MetR;
7-69 1.31e-03

HTH-type transcriptional regulator MetR;


Pssm-ID: 185319 [Multi-domain]  Cd Length: 317  Bit Score: 39.62  E-value: 1.31e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446272952   7 KKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQ 69
Cdd:PRK15421   5 KHLKTLQALRNCGSLAAAAATLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTPQGEILLQ 67
PRK10632 PRK10632
HTH-type transcriptional activator AaeR;
7-69 8.29e-03

HTH-type transcriptional activator AaeR;


Pssm-ID: 182601 [Multi-domain]  Cd Length: 309  Bit Score: 37.43  E-value: 8.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446272952   7 KKMRNFILLAQTNNIARAAEKIHMTASPFGKSIAALEEQIGYTLFTRKDNNISLNKAGQELYQ 69
Cdd:PRK10632   5 KRMSVFAKVVEFGSFTAAARQLQMSVSSISQTVSKLEDELQVKLLNRSTRSIGLTEAGRIYYQ 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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