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Conserved domains on  [gi|446284174|ref|WP_000362029|]
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MULTISPECIES: PIG-L deacetylase family protein [Gammaproteobacteria]

Protein Classification

PIG-L deacetylase family protein( domain architecture ID 10005328)

PIG-L (phosphatidylinositol glycan class L) deacetylase family protein may catalyze the removal of an acetyl group from a specific acetylated substrate

CATH:  3.40.50.10320
EC:  3.5.1.-
Gene Ontology:  GO:0019213
PubMed:  24970229
SCOP:  4001164

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LmbE COG2120
N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism];
19-216 2.08e-46

N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism];


:

Pssm-ID: 441723 [Multi-domain]  Cd Length: 201  Bit Score: 152.39  E-value: 2.08e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174  19 ILAIGAHPDDIELGCGASLARLAQKGIYIAAVVMTTGNSGTDGIID--------RHEESRNALKILGCHQTIHLNFADTR 90
Cdd:COG2120    2 VLVVAAHPDDEELGCGGTIARLAAAGHEVTVVTLTDGEAGSPGGPPlreelaeiRRAEARAAAAILGVSDVEFLGYPDGG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174  91 AHLQLNDMISALEDIIKnqipsDVEIMRVYTMHDADRHQDHLAVYQASMVACR-------TIPQILGYEtpsTWLSFMPQ 163
Cdd:COG2120   82 LEGPLEELRRALARLIR-----EVRPDVVLTPDPGDGHPDHRAVGRAVLAAARlaglpkiLGPRLYLYE---VPSDTEPD 153
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446284174 164 VFESVkEEYFTVKLAALKKHKSQERRDYmrhdRLRAVAQFRGQQVNSDLGEGF 216
Cdd:COG2120  154 VAVDI-TDVLERKLAALAAHASQLDPLF----AIRALARLRGAQAGVEYAEAF 201
 
Name Accession Description Interval E-value
LmbE COG2120
N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism];
19-216 2.08e-46

N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism];


Pssm-ID: 441723 [Multi-domain]  Cd Length: 201  Bit Score: 152.39  E-value: 2.08e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174  19 ILAIGAHPDDIELGCGASLARLAQKGIYIAAVVMTTGNSGTDGIID--------RHEESRNALKILGCHQTIHLNFADTR 90
Cdd:COG2120    2 VLVVAAHPDDEELGCGGTIARLAAAGHEVTVVTLTDGEAGSPGGPPlreelaeiRRAEARAAAAILGVSDVEFLGYPDGG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174  91 AHLQLNDMISALEDIIKnqipsDVEIMRVYTMHDADRHQDHLAVYQASMVACR-------TIPQILGYEtpsTWLSFMPQ 163
Cdd:COG2120   82 LEGPLEELRRALARLIR-----EVRPDVVLTPDPGDGHPDHRAVGRAVLAAARlaglpkiLGPRLYLYE---VPSDTEPD 153
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446284174 164 VFESVkEEYFTVKLAALKKHKSQERRDYmrhdRLRAVAQFRGQQVNSDLGEGF 216
Cdd:COG2120  154 VAVDI-TDVLERKLAALAAHASQLDPLF----AIRALARLRGAQAGVEYAEAF 201
PIG-L pfam02585
GlcNAc-PI de-N-acetylase; Members of this family are related to PIG-L an ...
20-141 4.33e-28

GlcNAc-PI de-N-acetylase; Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyzes the second step in GPI biosynthesis.


Pssm-ID: 426852  Cd Length: 128  Bit Score: 103.15  E-value: 4.33e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174   20 LAIGAHPDDIELGCGASLARLAQKGIYIAAVVMTTGNSGTDGIID---------RHEESRNALKILGCHQTIHLNFADTR 90
Cdd:pfam02585   1 LVVSAHPDDEELGAGGTIARLAAAGVEVHVVCLTDGEAGSGGGSLeegeelgeiRRAEARAAAEILGVDDVEFLDYPDGG 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446284174   91 AHLQLNDMIS-ALEDIIKNQIPsDVeimrVYTMHDADR-HQDHLAVYQASMVA 141
Cdd:pfam02585  81 LEYWDLEELLdALADLIRRYRP-DV----VVTPDPDGGgHPDHRATGRAVLAA 128
thiol_BshB1 TIGR04001
bacillithiol biosynthesis deacetylase BshB1; Members of this protein family are BshB1 (YpjG), ...
19-223 7.77e-22

bacillithiol biosynthesis deacetylase BshB1; Members of this protein family are BshB1 (YpjG), an enzyme of bacillithiol biosynthesis; either BshB1 or BshB2 (YojG) must be present, and often both are present. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 274915  Cd Length: 226  Bit Score: 89.24  E-value: 7.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174   19 ILAIGAHPDDIELGCGASLARLAQKGIYIAAVVMTTGNSGTDGIID-RHEESRNALKILGCHQTIHLNFADTrahlQLND 97
Cdd:TIGR04001   4 ILAFGAHPDDVELGCGGTIAKYVQQGYKVGICDLTRGELSSNGTVEsRQEEAAAAAEILGVSARINLGLPDR----GLNP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174   98 MISALEDIiknqipsdVEIMR------VYTMHDADRHQDHL--------AVYQASMvacRTIPQILGYE--TPSTWLSFM 161
Cdd:TIGR04001  80 TEENIREV--------VEVIRryrpklVFAPYPEDRHPDHGkaarlvteACFYAGL---RKYETETPQEphRPRHVYYYM 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174  162 ------PQVFESVkEEYFTVKLAALKKHKSQ------------ERRDYMrhDRLRAVAQFRGQQVNSDLGEGFVIHKMIL 223
Cdd:TIGR04001 149 qngfhePDFVVDV-SETYEQKRAALLAYKSQfyrppdspqtplTNGEFL--ESLEARDRYFGKQIGVAYGEGFILEKPLG 225
 
Name Accession Description Interval E-value
LmbE COG2120
N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism];
19-216 2.08e-46

N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism];


Pssm-ID: 441723 [Multi-domain]  Cd Length: 201  Bit Score: 152.39  E-value: 2.08e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174  19 ILAIGAHPDDIELGCGASLARLAQKGIYIAAVVMTTGNSGTDGIID--------RHEESRNALKILGCHQTIHLNFADTR 90
Cdd:COG2120    2 VLVVAAHPDDEELGCGGTIARLAAAGHEVTVVTLTDGEAGSPGGPPlreelaeiRRAEARAAAAILGVSDVEFLGYPDGG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174  91 AHLQLNDMISALEDIIKnqipsDVEIMRVYTMHDADRHQDHLAVYQASMVACR-------TIPQILGYEtpsTWLSFMPQ 163
Cdd:COG2120   82 LEGPLEELRRALARLIR-----EVRPDVVLTPDPGDGHPDHRAVGRAVLAAARlaglpkiLGPRLYLYE---VPSDTEPD 153
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446284174 164 VFESVkEEYFTVKLAALKKHKSQERRDYmrhdRLRAVAQFRGQQVNSDLGEGF 216
Cdd:COG2120  154 VAVDI-TDVLERKLAALAAHASQLDPLF----AIRALARLRGAQAGVEYAEAF 201
PIG-L pfam02585
GlcNAc-PI de-N-acetylase; Members of this family are related to PIG-L an ...
20-141 4.33e-28

GlcNAc-PI de-N-acetylase; Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyzes the second step in GPI biosynthesis.


Pssm-ID: 426852  Cd Length: 128  Bit Score: 103.15  E-value: 4.33e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174   20 LAIGAHPDDIELGCGASLARLAQKGIYIAAVVMTTGNSGTDGIID---------RHEESRNALKILGCHQTIHLNFADTR 90
Cdd:pfam02585   1 LVVSAHPDDEELGAGGTIARLAAAGVEVHVVCLTDGEAGSGGGSLeegeelgeiRRAEARAAAEILGVDDVEFLDYPDGG 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446284174   91 AHLQLNDMIS-ALEDIIKNQIPsDVeimrVYTMHDADR-HQDHLAVYQASMVA 141
Cdd:pfam02585  81 LEYWDLEELLdALADLIRRYRP-DV----VVTPDPDGGgHPDHRATGRAVLAA 128
thiol_BshB1 TIGR04001
bacillithiol biosynthesis deacetylase BshB1; Members of this protein family are BshB1 (YpjG), ...
19-223 7.77e-22

bacillithiol biosynthesis deacetylase BshB1; Members of this protein family are BshB1 (YpjG), an enzyme of bacillithiol biosynthesis; either BshB1 or BshB2 (YojG) must be present, and often both are present. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 274915  Cd Length: 226  Bit Score: 89.24  E-value: 7.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174   19 ILAIGAHPDDIELGCGASLARLAQKGIYIAAVVMTTGNSGTDGIID-RHEESRNALKILGCHQTIHLNFADTrahlQLND 97
Cdd:TIGR04001   4 ILAFGAHPDDVELGCGGTIAKYVQQGYKVGICDLTRGELSSNGTVEsRQEEAAAAAEILGVSARINLGLPDR----GLNP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174   98 MISALEDIiknqipsdVEIMR------VYTMHDADRHQDHL--------AVYQASMvacRTIPQILGYE--TPSTWLSFM 161
Cdd:TIGR04001  80 TEENIREV--------VEVIRryrpklVFAPYPEDRHPDHGkaarlvteACFYAGL---RKYETETPQEphRPRHVYYYM 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446284174  162 ------PQVFESVkEEYFTVKLAALKKHKSQ------------ERRDYMrhDRLRAVAQFRGQQVNSDLGEGFVIHKMIL 223
Cdd:TIGR04001 149 qngfhePDFVVDV-SETYEQKRAALLAYKSQfyrppdspqtplTNGEFL--ESLEARDRYFGKQIGVAYGEGFILEKPLG 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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