NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446287665|ref|WP_000365520|]
View 

MULTISPECIES: helix-turn-helix domain-containing protein [Bacillus]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
10-108 2.28e-42

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 134.61  E-value: 2.28e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446287665  10 GVIATLQIIGGKWKPLILFILLtDGMKRFGELKRLIPDISQGTLAKQLRELEQDQLIKREIYQEIPPKVEYSLTEHGKTV 89
Cdd:COG1733   11 PVRRALDVIGGKWKLLILRALL-DGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGRSL 89

                         90
                 ....*....|....*....
gi 446287665  90 STVLDSMCSWGRGHLEYID 108
Cdd:COG1733   90 LPVLDALAEWGEEHLPEIE 108
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
10-108 2.28e-42

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 134.61  E-value: 2.28e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446287665  10 GVIATLQIIGGKWKPLILFILLtDGMKRFGELKRLIPDISQGTLAKQLRELEQDQLIKREIYQEIPPKVEYSLTEHGKTV 89
Cdd:COG1733   11 PVRRALDVIGGKWKLLILRALL-DGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGRSL 89

                         90
                 ....*....|....*....
gi 446287665  90 STVLDSMCSWGRGHLEYID 108
Cdd:COG1733   90 LPVLDALAEWGEEHLPEIE 108
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 17-108 7.35e-38

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 122.80  E-value: 7.35e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446287665   17 IIGGKWKPLILFILLtDGMKRFGELKRLIPDISQGTLAKQLRELEQDQLIKREIYQEIPPKVEYSLTEHGKTVSTVLDSM 96
Cdd:pfam01638   1 LIGGKWKGLILRELL-DGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQEL 79

                          90
                  ....*....|..
gi 446287665   97 CSWGRGHLEYID 108
Cdd:pfam01638  80 CDWGEEYLEPED 91
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 26-84 1.01e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 1.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446287665  26 ILFILLTDGMkRFGELKRLIpDISQGTLAKQLRELEQDQLIKREiyqEIPPKVEYSLTE 84
Cdd:cd00090   12 ILRLLLEGPL-TVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTD 65
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
10-108 2.28e-42

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 134.61  E-value: 2.28e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446287665  10 GVIATLQIIGGKWKPLILFILLtDGMKRFGELKRLIPDISQGTLAKQLRELEQDQLIKREIYQEIPPKVEYSLTEHGKTV 89
Cdd:COG1733   11 PVRRALDVIGGKWKLLILRALL-DGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGRSL 89

                         90
                 ....*....|....*....
gi 446287665  90 STVLDSMCSWGRGHLEYID 108
Cdd:COG1733   90 LPVLDALAEWGEEHLPEIE 108
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 17-108 7.35e-38

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 122.80  E-value: 7.35e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446287665   17 IIGGKWKPLILFILLtDGMKRFGELKRLIPDISQGTLAKQLRELEQDQLIKREIYQEIPPKVEYSLTEHGKTVSTVLDSM 96
Cdd:pfam01638   1 LIGGKWKGLILRELL-DGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQEL 79

                          90
                  ....*....|..
gi 446287665   97 CSWGRGHLEYID 108
Cdd:pfam01638  80 CDWGEEYLEPED 91
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
27-112 1.40e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 39.11  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446287665  27 LFILLTDGMKRFGELKRLIpDISQGTLAKQLRELEQDQLIKREIYqeippkvEYSLTEHGKTVSTVLDSMCSwgrgHLEY 106
Cdd:COG4742   21 ILLLLAEGPKTRSELAESL-DVSRSTILRQLKELEERGLIERDDG-------EYELTTLGRLVVEEMEPLLD----TLEV 88


                 ....*.
gi 446287665 107 IDKDKP 112
Cdd:COG4742   89 LEENRD 94
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 26-84 1.01e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 1.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446287665  26 ILFILLTDGMkRFGELKRLIpDISQGTLAKQLRELEQDQLIKREiyqEIPPKVEYSLTE 84
Cdd:cd00090   12 ILRLLLEGPL-TVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTD 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH