|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
31-440 |
8.34e-136 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 396.32 E-value: 8.34e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 31 LVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFtd 110
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAF-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 111 ilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWV 190
Cdd:TIGR00893 79 -----AGAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFII 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 191 MGGLGIILSFIWLKVIYSPTNHPTVNPEEVKYIASEGALLDMGENSQNAKKekitWSKVKRLLASRMMLGIFIGQYCVNT 270
Cdd:TIGR00893 154 EGVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPK----KYQIKELLKDRRVWGLALGQFLVNI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 271 LTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRMNYSLSFSRKLPIVVGFLVSTSIILCNYD 350
Cdd:TIGR00893 230 GLGFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 351 DSQAAIVFFMSLSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLALTYVGVHAI 430
Cdd:TIGR00893 310 NIPYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALAL 389
|
410
....*....|
gi 446291608 431 AAVICYTVIV 440
Cdd:TIGR00893 390 IGALSYLLLV 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
22-439 |
7.07e-105 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 315.66 E-value: 7.07e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 22 RYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSL 101
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 102 FTVLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVAT 181
Cdd:cd17319 81 FTALTGF-------ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 182 VHWQSIFWVMGGLGIILSFIWLKVIysptnhptvnpeevkyiasegalldmgensqnakkekitwskvkrllasRMMLGI 261
Cdd:cd17319 154 FGWRWAFIIEGLLGLLLAVLWWFYL-------------------------------------------------RQVWGL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 262 FIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRmnyslsFSRKLPIVVGFLVS 341
Cdd:cd17319 185 ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR------GARRLVIIIGLLLA 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 342 TSIILCNY-DDSQAAIVFFMSLSFFGKGIGSLGWAVM-SDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFN 419
Cdd:cd17319 259 AVGLLLAYlTTSPVVAVILLSLAGFGIGAASPVFWSLpADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYT 338
|
410 420
....*....|....*....|
gi 446291608 420 LALTYVGVHAIAAVICYTVI 439
Cdd:cd17319 339 AAFLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-445 |
9.89e-76 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 240.93 E-value: 9.89e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 16 AKHTKTRYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWS 95
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 96 LFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLM 175
Cdd:COG2271 82 LLLWGLATLLFGF-------ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 176 GWLVATVHWQSIFWVMGGLGIILSFIwlkviysptnhptvnpeevkyiasegalldmgensqnakkekitwskvkrllas 255
Cdd:COG2271 155 GWLLAAFGWRAAFLILGLPGLLLALL------------------------------------------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 256 rMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRmnyslsfSRKLPIV 335
Cdd:COG2271 181 -RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR-------RRKLVLA 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 336 VGFLVST-SIILCNYDDSQAAIVFFMSL-SFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILA 413
Cdd:COG2271 253 IGLLLAAlALLLLALLPSPALAIALLFLaGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD 332
|
410 420 430
....*....|....*....|....*....|..
gi 446291608 414 STGsFNLALTYVGVHAIAAVICYTVIVGKIQR 445
Cdd:COG2271 333 ATG-YQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
27-435 |
5.15e-58 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 194.70 E-value: 5.15e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 27 AMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLI 106
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 107 GFTdilgdTATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQS 186
Cdd:cd17380 82 PLL-----AYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 187 IFWVMGGLGIILSFIWLKVIYSptnhptvnpeevkyiasegalldmgensqnakkekiTWSkvkrllasrmmlgIFIGQY 266
Cdd:cd17380 157 VFYFFGLLGLLWALVWLIYLPP------------------------------------VWA-------------IIVAHF 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 267 CVNTLTYFFLTWFPVYLvKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRMNYSLSFSRKLPIVVGFLVSTSIIL 346
Cdd:cd17380 188 CMNWGFYILLSWLPTYF-HEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 347 C-NYDDSQAAIVFFMSLSFFGKGIGSLGWAV-MSDVAPKEmVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLalty 424
Cdd:cd17380 267 LlSHTDSFSLALLCMSVALGLSAFSSSGVLVnHQDIAPNY-AGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSL---- 341
|
410
....*....|.
gi 446291608 425 vgVHAIAAVIC 435
Cdd:cd17380 342 --VFVLAAVVN 350
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-416 |
2.02e-56 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 191.05 E-value: 2.02e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 30 FLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFt 109
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGF- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 110 dilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMG-WLVATVHWQSIF 188
Cdd:TIGR00881 80 ------STSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfGIAELYSWHWVF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 189 WVMGGLGIILSFIWLKVIYSPTNHPTVNPEEVKYIAsegallDMGENSQNAKKEKITW-SKVKRLLASRMMLGIFIGQYC 267
Cdd:TIGR00881 154 IVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNE------EPDGDAEKKEEELTKKqIFLQYVLLNKVLWYISLGYVF 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 268 VNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRMN-YSLSFSRKLPIVVGFLVSTSIIL 346
Cdd:TIGR00881 228 VYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRrGPLAVFFMALIIVSLLVYWLNPA 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 347 CNYddsQAAIVFFMSLSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTG 416
Cdd:TIGR00881 308 ANP---LMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-435 |
1.01e-47 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 168.52 E-value: 1.01e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 20 KTRYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLW 99
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 100 SLFTVLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLV 179
Cdd:COG2223 81 GIGLLLLAL-------AVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 180 ATVHWQSIFWVMGGLGIILSFIWLKVIYSPTNHPTVnpeevkyiASEGALLDMGEnsqnAKKEKITWskvkrllasRMML 259
Cdd:COG2223 154 AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAA--------AAKASLRDQLE----ALRDPRFW---------LLSL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 260 GIFIGQYCVntltYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRmnyslsfsRKLPIVVGFL 339
Cdd:COG2223 213 LYFGTFGSF----IGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG--------RRVLLIVFAL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 340 VSTSIILCNY--DDSQAAIVFFMSLSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGS 417
Cdd:COG2223 281 MALGLLLLALalGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGS 360
|
410
....*....|....*...
gi 446291608 418 FNLALTYVGVHAIAAVIC 435
Cdd:COG2223 361 YTAAFLVFAVLALVALVL 378
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
28-412 |
2.54e-47 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 167.41 E-value: 2.54e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 28 MIFLVTAFNYGDRATLSMAATPMSHELGI----------------------DSVTMGYIFSAFAWAYVIGQIPGGWLLDK 85
Cdd:cd17318 3 LLFLGFAVVYAMRVNLSVAIVAMVNSTAThdnnntstdkdtlpveapefdwSEKTQGIILSSFFYGYILTQIPGGYLAEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 86 FGARRVYFWSLFLWSLFTVLIGFTDILGdtatiITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSY 165
Cdd:cd17318 83 YGAKRVLGYSILITALLTLLTPLAARGG-----YGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 166 FSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIWLKVIysptnhptvnpeevkyiasegalldmgensqnakkekit 245
Cdd:cd17318 158 FGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV--------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 246 wskvkrllasRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRMN-Y 324
Cdd:cd17318 199 ----------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGiL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 325 SLSFSRKLPIVVGFLVSTSIILC-NYDDSQA-AIVFFMSLSFFGKGIGSLGWAV-MSDVAPKemvgLSGGMM---NAFGN 398
Cdd:cd17318 269 STTTVRKLFTSIGFLGPGVFLIAlGYLGSNAtLAVVFLTLSVGLSGACYSGFLVnHLDLAPN----YAGTLMgitNTAAT 344
|
410
....*....|....
gi 446291608 399 TAGIVTPIVIGYIL 412
Cdd:cd17318 345 IAGIISPLIVGAIV 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-401 |
6.39e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 135.49 E-value: 6.39e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 16 AKHTKTRYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWS 95
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 96 LFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLM 175
Cdd:COG2814 82 LLLFALGSLLCAL-------APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 176 GWLVATVHWQSIFWVMGGLGIILSFIWLKVIysPTNHPTVNPEEvkyiasegalldmgensqnakkekitWSKVKRLLAS 255
Cdd:COG2814 155 GLLADLFGWRWVFLVNAVLALLALLLLLRLL--PESRPAARARL--------------------------RGSLRELLRR 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 256 RMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIV 335
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR---------FGRRRLLL 277
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446291608 336 VGFLVST-SIILCNYDDSQAAIVFFMSLSFFGKG-IGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAG 401
Cdd:COG2814 278 IGLLLLAlGLLLLALAGSLWLLLLALFLLGFGFGlLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
29-436 |
2.86e-35 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 134.48 E-value: 2.86e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 29 IFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGF 108
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 109 tdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLV--ATVHWQS 186
Cdd:cd06174 81 -------APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 187 IFWVMGGLGIILSFIWLKVIYSPTNHPTVNPEEvkyiasegalldmgensqnaKKEKITWSKVKRLLASRMMLGIFIGQY 266
Cdd:cd06174 154 VFLIAAALALLAAILLLLVVPDPPESARAKNEE--------------------ASSKSVLKLLKRVLKNPGLWLLLLAIF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 267 CVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIrmnyslsfSRKLPIVVGFLVST--SI 344
Cdd:cd06174 214 LVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI--------GRKPLLLIGLLLMAlgLA 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 345 ILCNYDDSQAAIVFFMSLSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLALTY 424
Cdd:cd06174 286 LLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLV 365
|
410
....*....|..
gi 446291608 425 VGVHAIAAVICY 436
Cdd:cd06174 366 LAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-405 |
6.77e-34 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 129.85 E-value: 6.77e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 29 IFLVTAFNYGDRATLSMAATP-MSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIG 107
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 108 FtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSI 187
Cdd:pfam07690 81 F-------ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 188 FWVMGGLGIILSFIWLKVIYSPTNHPTVNPEEVKYIAsegalldmgensqnakkekitwSKVKRLLASRMMLGIFIGQYC 267
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL----------------------IVAWKALLRDPVLWLLLALLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 268 VNTLTYFFLTWFPVYlVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRMnyslsFSRKLPIVVGFLVSTSIILC 347
Cdd:pfam07690 212 FGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR-----RRLLLALLLLILAALGLLLL 285
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446291608 348 NYDDSQAAIVFFMSLSFFGKGI-GSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTP 405
Cdd:pfam07690 286 SLTLSSLWLLLALLLLGFGFGLvFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
22-439 |
4.82e-31 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 122.38 E-value: 4.82e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 22 RYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSL 101
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 102 FTVLIGFTdilgdtaTIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVAT 181
Cdd:cd17312 81 ANIFMGFS-------TSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 182 VHWQSIFWVMGGLGIILSFIWLKVIYsptNHPTVnpeevkyiasegalldmgensqnakkekitwskvkrllasrmMLGI 261
Cdd:cd17312 154 YGWRAAFLVPGIVGLVVAIILFFFLR---DSPPY------------------------------------------VWVL 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 262 FIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRmnyslsfSRKLPIVVGFLVS 341
Cdd:cd17312 189 SLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFG-------GRRAPIAVIYMLL 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 342 TSIILCNY-----DDSQAAIVFFMSLSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTG 416
Cdd:cd17312 262 MTLSLALFwffphNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYG 341
|
410 420
....*....|....*....|...
gi 446291608 417 SFNLALTYVGVHAIAAVICYTVI 439
Cdd:cd17312 342 WSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
52-434 |
5.86e-31 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 122.68 E-value: 5.86e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 52 HELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGL 131
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF-------ATSYWQLLLARFLQGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 132 SESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIWLKVIysptn 211
Cdd:cd17325 97 ASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLL----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 212 HPTVNPEEvkyiasegalldmgensQNAKKEKITWSKVKRLLASRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSI 291
Cdd:cd17325 172 PEPRPPPN-----------------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 292 LEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIVVGFLVST-SIILCNYDDSQAAIVFFMSLSFFGKGIG 370
Cdd:cd17325 235 AQIGLLFGAQGLASALSQPPAGKLSDR---------IGRKPLILIGLLLSAvALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446291608 371 SLGW-AVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLALTYVGVHAIAAVI 434
Cdd:cd17325 306 FPATlALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVL 370
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
62-435 |
1.33e-30 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 122.93 E-value: 1.33e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 62 GYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTDILGdtatiITSLFILRFLVGLSESPAFPGNS 141
Cdd:TIGR00894 79 GLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGG-----IALVVFCRVIQGLAQGSVSPATH 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 142 KIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLV-ATVHWQSIFWVMGGLGIILSFIWLKVIYS-PTNHPTVNPEE 219
Cdd:TIGR00894 154 KIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADdPSIHPCISKFE 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 220 VKYIASEgallDMGENSQNAKKEKItwskvKRLLASRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAV 299
Cdd:TIGR00894 234 KKYINSS----LQGQKGSTRQSLPI-----KAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSS 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 300 APALCGFVGGILGGLTSDKLIRMNY-SLSFSRKLPIVVGFLVSTSIILCNYDDSQA---AIVFFM------SLSFFGKGI 369
Cdd:TIGR00894 305 LPYLFAWLCSIFAGYLADFLKSSKTlSLTAARKIFNGIGGLGPGIFAYALPYLSAAfylTIIILTlanavsSGPLAGVLI 384
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446291608 370 GSLgwavmsDVAPKeMVGLSGGMMNAFGNTAGIVTPIVIGYILaSTGSFNLALTYVGVHAIAAVIC 435
Cdd:TIGR00894 385 NSL------DLAPR-FLGFIKGITGLPGFIGGLIASTLAGNIL-SQDSKNVWLIVFLIMAFVNILC 442
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
53-434 |
1.98e-28 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 115.41 E-value: 1.98e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 53 ELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFwslflwsLFTVLIGFTDILGDTATIITSLFILRFLVGLS 132
Cdd:cd17475 25 DLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLA-------VGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 133 ESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGI---ILSFIWLKviysp 209
Cdd:cd17475 98 YGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSIlaaVLFWLFYR----- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 210 tnhptvNPEEVKYiasegalldmgensqNAKKEKITWSKVKRLLASRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHL 289
Cdd:cd17475 173 ------EPPAASA---------------ATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 290 SILEAGFAAVAPALCGFVGGILGGLTSDKLIRMNyslsfsRKLPIVVGFLVSTSIILCNYDDSQAAIVFFMSLSFFGKGI 369
Cdd:cd17475 232 SVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGR------RRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446291608 370 GSLGW-----AVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLA-LTYVGVHAIAAVI 434
Cdd:cd17475 306 FAIGWnglylTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAwLALALLLVLAALL 376
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
11-412 |
3.43e-28 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 115.15 E-value: 3.43e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 11 VTQQRAKHTKTRYYILAMI--FLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGA 88
Cdd:TIGR00895 2 VQNNIRKQPLSRYQWRAIIlsFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 89 RRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFST 168
Cdd:TIGR00895 82 RRVLLWSILLFSVFTLLCAL-------ATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 169 VLFAPLMGWLVATVHWQSIFWVMGGLGIIL----------SFIWLKVIYSPTNHPTVNPEEVKYIASEGALLDmgENSQN 238
Cdd:TIGR00895 155 AVGGFLAGWLIPVFGWRSLFYVGGIAPLLLllllmrflpeSIDFLVSKRPETVRRIVNAIAPQMQAEAQSALP--EQKST 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 239 AKKEKITWSKVKRLLASRMMLGIFIGQYCVNTLTYFFLTWFPvYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDK 318
Cdd:TIGR00895 233 QGTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 319 LIR---MNYSLSFSRKLPIVVGFLVSTSIILcnyddSQAAIVFFmslsFFGKGIGSLGwAVMSDVAPKEMVGLSGGMMNA 395
Cdd:TIGR00895 312 LGPrvtALLLLLGAVFAVLVGSTLFSPTLLL-----LLGAIAGF----FVNGGQSGLY-ALMALFYPTAIRATGVGWAIG 381
|
410
....*....|....*..
gi 446291608 396 FGNTAGIVTPIVIGYIL 412
Cdd:TIGR00895 382 IGRLGAIIGPILAGYLL 398
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
26-435 |
1.09e-24 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 104.61 E-value: 1.09e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 26 LAMIFLVTAFNYGDRATLSMAATPMSHE--LGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFT 103
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 104 VLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFApLMGWLVATVH 183
Cdd:cd17316 81 LLIGL-------LPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAA-LVASLLIPLL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 184 -----WQSIFWVMGGLGIILSFIWlkviysptnhptvnpeevkyiasegalldmgensqnakkekitwskvkrllasRMM 258
Cdd:cd17316 153 sgdwgWRILFLIGALPALLALLLR-----------------------------------------------------RRT 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 259 LGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIVVGF 338
Cdd:cd17316 180 LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR---------IGRKKTLVIGL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 339 LVST--SIILCNYDDSQAAIVFFMS--LSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILAS 414
Cdd:cd17316 251 ILSGilALPLFYLLSGSPTLLLLLLfiLSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
|
410 420
....*....|....*....|.
gi 446291608 415 TGSFNLALTYVGVHAIAAVIC 435
Cdd:cd17316 331 TGGTGVPALILALLAIVALIV 351
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
20-405 |
2.05e-24 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 104.64 E-value: 2.05e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 20 KTRYYILAMIFLVTAFNYGDRATLSMAATP-MSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFL 98
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 99 WSLFTVLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVlFAPLMGWL 178
Cdd:cd17327 81 WGLLTLLTAA-------VKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSI-FGGLLAYG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 179 VATVH-------WQSIFWVMGGLGIILSFIWLkvIYSPTNHPTV---NPEEVKYIASEgalldMGENSQNAKKEKITWSK 248
Cdd:cd17327 153 VFKILgvgglagWRWLFIIEGLITIIIGLVIF--FWLPDNPSKAwflTEEEKELAVER-----LRANQTGKGDQKFKWKQ 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 249 VKRLLASRMMLGIFIGQYCVNTLTYFFLTWFPVyLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsF 328
Cdd:cd17327 226 IKEAFKDPRTWLLFLFFFCSQITNNGISNFLPL-ILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDR---------F 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 329 SRKLPIVVGF--LVSTSIILCNYDDSQAAIVFFMSLSFFGKGIGS---LGWAVmSDVAPKEMVGLSGGMMNAFGNTAGIV 403
Cdd:cd17327 296 KKRGLFAIFAcvLALVGSIILLAAPNPPGAYFAAYILGGGSYAGFpilLSWIS-SNCAGYTKRATVLAIMLIFYNVGNIV 374
|
..
gi 446291608 404 TP 405
Cdd:cd17327 375 AP 376
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
22-436 |
2.30e-24 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 104.25 E-value: 2.30e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 22 RYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSL 101
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 102 FTVLIGFTDILGDTATIitsLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVAT 181
Cdd:cd17345 81 INILIGFVPSATSSVGL---MFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 182 V---HWQSIFWVMGGLGIILSFIWLKVIYSptnhptvNPEEV------KYIASEGALLDMGENSQNAKKEKITWskvKRL 252
Cdd:cd17345 158 FgdgWWRGAFIFPAIIAIIVAVIVLFLGKD-------TPESEglppieEYKGDYPEEADGEEEEQELSAWEIFV---KYV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 253 LASRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRmnyslsfSRKL 332
Cdd:cd17345 228 LKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFK-------GRRA 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 333 PIVVGFLVSTSIILCNYDDSQAAIVFFMSLSFfgkgIGSL--------GWAVMsDVAPKEMVGLSGGMMNAFGNTAG-IV 403
Cdd:cd17345 301 PTGIIFMILVIVALIVYWLAPNVLVDLIALIA----LGFLiygpvmliGLQAL-ELVPKKAAGTAAGLTGLFGYLGGsVL 375
|
410 420 430
....*....|....*....|....*....|...
gi 446291608 404 TPIVIGYILASTGsFNLALTYVGVHAIAAVICY 436
Cdd:cd17345 376 ATALIGIIVDHFG-WNGGFIVLLASCILAIIFL 407
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
57-411 |
5.15e-24 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 103.32 E-value: 5.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 57 DSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTDILGdtatiITSLFILRFLVGLSESPA 136
Cdd:cd17381 63 DAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLG-----AGYLIAVRALEGLGEGVT 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 137 FPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIWLKVIYSptnhptvn 216
Cdd:cd17381 138 FPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVMP-------- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 217 peevkyiasegalldmgensqnakkekitwskvkrllasrmMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGF 296
Cdd:cd17381 210 -----------------------------------------LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGF 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 297 AAVAPALCGFVGGILGGLTSDKLI-RMNYSLSFSRKLPIVVG------FLVSTSIILCNYddsqAAIVFFMSLSFFGKGI 369
Cdd:cd17381 249 LSALPYLGCWLFMILSGQIADNLReKQNFSTVCVRKIFTLIGmigpavFLLAAGFTGCNY----SLAVAFLTISSTLGGF 324
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 446291608 370 GSLGWAVMS-DVAPKeMVGLSGGMMNAFGNTAGIVTPIVIGYI 411
Cdd:cd17381 325 SASGFNINHlDIAPS-YAGILLGITNTFATIPGMVGPVIAKSL 366
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
30-434 |
1.02e-23 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 102.38 E-value: 1.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 30 FLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFt 109
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGF- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 110 dilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSY----FSTVLFAPLMGWLVATVHWQ 185
Cdd:cd17371 84 ------AQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwlLATLLAALLFPLLPPEIAWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 186 SIFWVMGGLGIILSFIWLKViysptnhptvnPEEVKYIASEGAlldmgeNSQNAKKEKITWSKVKRLLasRMMLGIFIGQ 265
Cdd:cd17371 158 VLFLLGALPALLVLFIRRFV-----------KEPPQWQAARAA------RRHFADRPSLRELFSPPLL--RTTLLASLLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 266 YCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIVVGFLVSTSII 345
Cdd:cd17371 219 TGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADR---------IGRRNNFALFALGSAISI 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 346 LC--NYDDSQAAIVFFMS-LSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLAL 422
Cdd:cd17371 290 LLyfFLPLSPTLILILGFpLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIA 369
|
410
....*....|..
gi 446291608 423 TYVGVHAIAAVI 434
Cdd:cd17371 370 VFAAVYYIAGLV 381
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
26-411 |
1.82e-22 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 98.85 E-value: 1.82e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 26 LAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVL 105
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 106 IGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLV-ATVHW 184
Cdd:cd17328 81 SSF-------APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGW 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 185 QSIFWVMGGLGIILSFIWLKVIysptnhptvnpEEVKYIASEGALLDMGENSQNAKKEKITWSKVKRLLASrmmLGIFIG 264
Cdd:cd17328 154 RWAFRVTGVLGVLLAILLLLFV-----------REPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILST---LGFTAV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 265 QYCVNTLTYffltWFPVYLVKERHLSILEAGFAAVA----PALCGFVGGILGGLTSDKLIRMNyslsfSRKLPIV--VGF 338
Cdd:cd17328 220 SFVTGALAF----WAPTFFLRAFGVGDLSSADVGLIfgaiTCIAGVLGVLLGGILADRLRRKT-----PRADPLVcaVGL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 339 LVSTSIILCNYDDSQAAIVFFMSLSFFGKGIGSLGWAVMSD----VAPKEM----VGLSGGMMNAFGNTAGivtPIVIGY 410
Cdd:cd17328 291 LAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAillyVVIPTRrstaSAIQILLSHLLGDAGS---PYLIGL 367
|
.
gi 446291608 411 I 411
Cdd:cd17328 368 I 368
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
25-433 |
1.09e-20 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 93.01 E-value: 1.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 25 ILAMIFLVTAFNygdrATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTV 104
Cdd:cd17321 1 LLLAVFLAALDV----TIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 105 LIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHW 184
Cdd:cd17321 77 LCAL-------APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGW 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 185 QSIFWVMGGLGIILsfiwlkviysptnhptvnpeevkyiasegalldmgensqnakkekitwskvkrLLASRMMLGIFIG 264
Cdd:cd17321 150 RWIFLINVPIGLVA-----------------------------------------------------LLLARTFSGAVLA 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 265 QYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIVVGFLVST-- 342
Cdd:cd17321 177 AFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADR---------FGPRLVLVAGLLLTAvg 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 343 SIILCNYDDSQAAIVFFMSLSFFGKGIG---SLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFN 419
Cdd:cd17321 248 LLLLALLGADSSVWLLLPGLVLLGLGLGlfaTPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSAN 327
|
410
....*....|....
gi 446291608 420 LALTYVGVHAIAAV 433
Cdd:cd17321 328 LGDSGVAALLSAAA 341
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
48-435 |
2.99e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 91.84 E-value: 2.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 48 TPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRF 127
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL-------APSFALLLLARA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 128 LVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSF-IWLKVI 206
Cdd:cd17324 96 LAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALlLWRLLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 207 YSPTNHPTVNPeevkyiasegalldmgensqnakkekiTWSKVKRLLASRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKE 286
Cdd:cd17324 176 SLPPKKPGSLG---------------------------LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 287 RHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRMNYSLsfsrkLPIVVGFLVSTSIILCNYDDSQAAIVFFMSLSFFg 366
Cdd:cd17324 229 PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI-----ALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF- 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446291608 367 kGIGSLGWAVMSDVAPkEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLALTYVGVHAIAAVIC 435
Cdd:cd17324 303 -AAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
25-434 |
3.96e-20 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 92.01 E-value: 3.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 25 ILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTV 104
Cdd:cd17343 4 IFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 105 LIGFTDILgdtatiiTSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLfAPLMGWLVATVH- 183
Cdd:cd17343 84 AFSGSSSV-------WVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSL-GPILATLLALSYg 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 184 WQSIFWVMGGLGIILSFIWLKVIYSPTNHPTVNPEEVkyiasegalldmGENSQNAKKEKITWSKVKRLLASRMMLGIFI 263
Cdd:cd17343 156 WRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEE------------EESKGKKKKSPRGESTLKELLLSPFLWLLSL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 264 GQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLI-RMNYSLSFSRKLPIVVGFL--V 340
Cdd:cd17343 224 GYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVaKHGSSSRGNPRMPLALVFMagL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 341 STSIILCNYDDSQAAIVFFMSLSFFGKGIGSLGWAVMSDV-----APKEMVGLSGGMMNAFGNTAGIVTPIVIGYIlAST 415
Cdd:cd17343 304 TVSLHLFRVHITSDSSELFILLLGFLIGFSLYGPIAIFGVianesAPSHLCGTSHAIVALAANVGGVLAGLPFSYI-AKH 382
|
410
....*....|....*....
gi 446291608 416 GSFNLALTYVGVHAIAAVI 434
Cdd:cd17343 383 YDWRTAFLLLEILCAITVV 401
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
12-208 |
4.04e-20 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 90.26 E-value: 4.04e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 12 TQQRAKHTKTRYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRV 91
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 92 YFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLF 171
Cdd:COG0477 82 LLIGLLLFGLASLLCGL-------APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALG 154
|
170 180 190
....*....|....*....|....*....|....*..
gi 446291608 172 APLMGWLVATVHWQSIFWVMGGLGIILSFIWLKVIYS 208
Cdd:COG0477 155 PLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPES 191
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
9-435 |
2.66e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 89.55 E-value: 2.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 9 AVVTQQRAKHTKTRYYILAMIFLVtAFNYgdRATLSMAA---TPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDK 85
Cdd:COG2807 3 TTSSSARRSRRAGRWLLLLAIVLV-ALNL--RPAITSVGpllPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 86 FGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKeRGTAAAIFNSSSY 165
Cdd:COG2807 80 FGLERTLLLALLLLAAGLLLRSL-------APSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 166 FSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIWLKVIYSPTNHPTVNPEEVkyiasegalldmgensqnakkekit 245
Cdd:COG2807 152 LGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAA------------------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 246 wsKVKRLLASRM--MLGIFIGqyCVNTLTYFFLTWFPVYLVkERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRmn 323
Cdd:COG2807 207 --SLRSLWRSPLawLLTLFFG--LQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGD-- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 324 yslsfSRKLPIVVGFLVSTSIILCNYDDSQAAIVFFMSLSFFGKGIGSLGWAVMSDVAP-KEMVGLSGGMMNAFGNTAGI 402
Cdd:COG2807 280 -----RRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAA 354
|
410 420 430
....*....|....*....|....*....|...
gi 446291608 403 VTPIVIGYILASTGSFNLALtyvGVHAIAAVIC 435
Cdd:COG2807 355 LGPLLVGALHDATGSWTAAL---LLLAALAVLM 384
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
60-411 |
5.23e-18 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 85.47 E-value: 5.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 60 TMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTDILGDTATIItslfiLRFLVGLSESPAFPG 139
Cdd:cd17382 50 TVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIF-----VRILQGLVEGVTYPA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 140 NSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIWLKViysptnhptvnpee 219
Cdd:cd17382 125 CHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV-------------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 220 vkyiasegalldmgensqnakkekitwskvkrllaSRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAV 299
Cdd:cd17382 191 -----------------------------------SMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 300 APALCGFVGGILGGLTSDKLiRMNYSLSFS--RKLPIVVGFLVSTSIILC-NYDDSQAAIVFFMSLSFFGKGIGSLGWAV 376
Cdd:cd17382 236 LPHLVMTIIVPIGGQLADYL-RSRGILSTTavRKIFNCGGFGMEATFLLVvAFSHSPTVAISFLVLAVGFSGFAISGFNV 314
|
330 340 350
....*....|....*....|....*....|....*.
gi 446291608 377 MS-DVAPKEMVGLSgGMMNAFGNTAGIVTPIVIGYI 411
Cdd:cd17382 315 NHlDIAPRYASILM-GISNGIGTLSGMVCPVIVGAL 349
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
50-438 |
3.33e-17 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 83.00 E-value: 3.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 50 MSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTDilgdtatIITSLFILRFLV 129
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSD-------SFALLLAGRALQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 130 GLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFaPLMGWLVATVHWQSIFWVMGGLGIILSFIWLKVIYSP 209
Cdd:cd17474 98 GIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 210 TNHPTvnpeevkyiasegalldmgensqnaKKEKITWSKVKRLLASRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHL 289
Cdd:cd17474 177 KEKAK-------------------------SSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 290 SILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslSFSRKLPIVVGFLVST-SIILCNYDDSQAaiVFFMSLSFFGKG 368
Cdd:cd17474 232 SPIIIGLLFAGWSVLLALGSLFVGRLLKK--------RFGARRILVIGLLLYAlSLLLLGFVPSLA--LLLIAIVLFGLG 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446291608 369 IG---SLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLALTYVGVHAIAAVICYTV 438
Cdd:cd17474 302 LGlnlPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
17-445 |
4.08e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 82.59 E-value: 4.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 17 KHTKTRYYILAMIFLVTAFNYgdrATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSL 96
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFAT---ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 97 FLWSLFTVLIGFTDILGdtaTIITSLFILRFLVGLSESPAFPgnskIAAAWFPTKERG--TAAAIFNSSSYFSTVLFAPL 174
Cdd:COG0738 81 LLMALGLLLFALAPSYP---LLLLALFLLGLGLGLLDVAANP----YVAALGPETAASrlNLLHAFFSLGALLGPLLGGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 175 MGWLVATVHWQSIFWVMGGLGIILSFIWLKViysptnhptvnpeevkyiasegallDMGENSQNAKKEKITWSKVKRLLA 254
Cdd:COG0738 154 LILLGLSLSWHLPYLILAVLLLLLALLFLRS-------------------------KLPEIEEEEEEAAGSAASLKSLLK 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 255 SRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPI 334
Cdd:COG0738 209 NPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR---------FGPVRLL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 335 VVGFLVST--SIILCNYDDSQAAIVFFMSLSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMnAFGNTAGIVTPIVIGYIl 412
Cdd:COG0738 280 RLSALLAAvgLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL-IMGIVGGAIGPPLIGFL- 357
|
410 420 430
....*....|....*....|....*....|...
gi 446291608 413 ASTGSFNLALTYVGVhAIAAVICYTVIVGKIQR 445
Cdd:COG0738 358 ADAFGLRAAFLVPLV-CYLLILLLALALKRKRR 389
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
53-435 |
5.61e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 76.06 E-value: 5.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 53 ELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGLS 132
Cdd:cd17478 25 KLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF-------APNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 133 ESPAFPGNSKIAAAwFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIWLKVIYSPTNH 212
Cdd:cd17478 98 SAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 213 PTVNPEEVKyiasegalldmgensqNAKKEKITWSKVKRLLASRMMLGIFigqycvntlTYFFLTWFPVYLVkERHLSIL 292
Cdd:cd17478 177 AKKAAAKSS----------------ARSTLKGVWRALLLLLIIVFLRSWV---------LSSLTTFLPFYLV-QRGYSLV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 293 EAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIVVGFLVST-SIILCNYDDSQAAIVFFMSLSFFGKGIGS 371
Cdd:cd17478 231 FAGLLLSLFLFAGAIGTLIGGPLSDR---------FGRRRVIIASLLLAApFLLLFLLTPGIWSYILLVLAGFLLFASFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446291608 372 LGWAVMSDVAPkEMVGLSGGMMNAFGNTAGIVTPIVIGYIlASTGSFNLALTYVGVHAIAAVIC 435
Cdd:cd17478 302 VTVVLAQELLP-GNVGLASGLMMGLSFGLGGIGAPVLGAL-ADAFGLESVLLILALLPLLGALL 363
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
25-434 |
6.13e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 76.16 E-value: 6.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 25 ILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTV 104
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 105 LIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNS-KIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVH 183
Cdd:cd17355 84 LLAL-------ATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 184 WQSIFWVMGGLGIILSFIwlkVIYSPTNHPTVNPEEVKYIASEGALLdmgensqnakkekitwSKVKRLLASRMMLGIFI 263
Cdd:cd17355 157 WRTALLVLALLALLVLVP---VLLLLRRRPADLALRAYDDASPASPG----------------STLKEALRSASFWLLAL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 264 GQYCVNTLTYFFLTWFPVYLVkERHLSILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIVVGFL---V 340
Cdd:cd17355 218 AFFLCGFAVVGLIVHLVPYLA-DRGISPAAAAVALALIGLFNIVGRLLSGWLGDR---------YSPRRLLAASYAlraL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 341 STSIILCNYDDSQAAIVFFMSLSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNL 420
Cdd:cd17355 288 GLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTA 367
|
410
....*....|....
gi 446291608 421 ALTYVGVHAIAAVI 434
Cdd:cd17355 368 AWALAVALGLIAAL 381
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
26-439 |
1.05e-14 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 75.38 E-value: 1.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 26 LAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVL 105
Cdd:PRK11551 17 IGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 106 IGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQ 185
Cdd:PRK11551 97 TAQ-------AWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 186 SIFWVmGGLG----IILSFIWLkviysptnhptvnPEEVKYIASEGALldmgensqnAKKEKITWSKVKRLLASRMMLgI 261
Cdd:PRK11551 170 HIFYV-GGVGplllVPLLMRWL-------------PESRAFAQAAGAG---------KQRAPVLRALFGEGRATATLL-L 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 262 FIGQYCVNTLTYFFLTWFPVYLVkERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLirmnyslsfsRKLPIVVGFLVS 341
Cdd:PRK11551 226 WISYFFTLIVLYFLLNWLPSLLV-GQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRL----------RPRRVVLLIYAG 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 342 TSIILCNYddSQAAIVFFMSLSFFGKGIGSLG-----WAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILA-ST 415
Cdd:PRK11551 295 ILASLAAL--AAAPSFAGMLLAGFAAGLFVVGgqsvlYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLAlGR 372
|
410 420
....*....|....*....|....
gi 446291608 416 GSFNLALTYVGVHAIAAVICYTVI 439
Cdd:PRK11551 373 STVGVIGASIPVILVAALAALLLV 396
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-436 |
2.17e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 74.15 E-value: 2.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 50 MSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTDILgdtatiiTSLFILRFLV 129
Cdd:cd17473 26 AQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL-------YALLASRALL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 130 GLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLvATVHWQSIFWVMGGLGIILSFIWLKVIYSP 209
Cdd:cd17473 99 GIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVYLLALPVLILVLLFLPEPA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 210 TNHPTVNpeevkyiasegalldmgeNSQNAKKEKITWSKVkrllasrmmLGIFIGQYCVNTLTYFFLTWFPVYLVKERHL 289
Cdd:cd17473 178 RKSKSAA------------------SPGAATAAALPWKRV---------LPIYFLAFLAMLLFYVIPIQLPFLLQERGGG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 290 SILEAGFAAVAPALCGFVGGILGGLTSDKLirmnyslsFSRKLPIVVGFLVSTSIILCNYddSQAAIVFFMSLSFFGKGI 369
Cdd:cd17473 231 SAALIGLALAIASLAGAIGALLFGRLKRRL--------GKRRLLAIGFALMALGFLLLAL--ASGLWVVLLGAILAGLGF 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 370 GSLGWAVMS---DVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLALTYVGVHAIAAVICY 436
Cdd:cd17473 301 GLLLPTLNSwamSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-203 |
5.88e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.99 E-value: 5.88e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 22 RYYILAMIFLVTAFNYGDR-ATLSMAATpmsHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWS 100
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALePFLPLYAA---ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 101 LFTVLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVA 180
Cdd:cd17325 277 VALLLLPL-------ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
|
170 180
....*....|....*....|...
gi 446291608 181 TVHWQSIFWVMGGLGIILSFIWL 203
Cdd:cd17325 350 AFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
43-421 |
2.15e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 71.45 E-value: 2.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 43 LSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSL 122
Cdd:cd17503 15 VNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL-------APNLASL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 123 FILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIw 202
Cdd:cd17503 88 IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 203 lkviysptnhptvnpeevkyiaseGALLDMGensqnakkekitWSKVKRL-LASRMMLGIFIGQYCVNTLtyffltwFPV 281
Cdd:cd17503 167 ------------------------APLLDLR------------LFKDRNFtLGLLLSFLLGLGLFGAMFL-------LPL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 282 YLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIVVGFLVS--TSIILCNYDDSQAAIVFF 359
Cdd:cd17503 204 YLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDK---------FGPRLLLLAGLLLLalGTLLLAFLTPDTSLWLII 274
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446291608 360 MSLSFFGKGIGsLGWAVMSDVA----PKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLA 421
Cdd:cd17503 275 LPLFIRGLGMG-LVFMPLNTLAlnslPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHS 339
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
74-434 |
6.77e-13 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 69.97 E-value: 6.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 74 IGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTdilgdtATIITSLFILRFLVGLSESpAFPGNSKIAAAWFPTKER 153
Cdd:cd17341 49 LLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALA------VSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPKEKI 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 154 GTAAAIF----NSSSYFSTVLFAPLMGWLV---ATVHWQSIFWVMGGLGIILSFIWLKVIYSPTNHPTVNPEEVKYIAse 226
Cdd:cd17341 122 GGAAGGIagagNMGVAVSQLLAPLIAGAIVfdgGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQL-- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 227 galldmgensqNAKKEKITWskvkrllasRMML------GIFIGqycvntltyfFLTWFPVYLVKERHLSILEAGFAAVA 300
Cdd:cd17341 200 -----------AVLKNYRTW---------ILSLlygvtfGSFVG----------FSNVLPTYFKTRFGLPLVTAGILAAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 301 PALCGFVGGILGGLTSDKLirmnyslsFSRKLPIVVGFLVSTSIILCNYDDSQAAIVFF-----MSLSFFGKGIGS-LGW 374
Cdd:cd17341 250 FPLAGALARPAGGWLSDRF--------GGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVlflalFVALGLGAGAGNgSVF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 375 AVMSDVAPKEMvGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLALTYVGVHAIAAVI 434
Cdd:cd17341 322 RMVPFIFRREL-GAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTL 380
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-209 |
8.05e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 69.52 E-value: 8.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 22 RYYILAMIFLVTAFNYgdrATLSMAATPMSHE-LGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWS 100
Cdd:COG2223 206 RFWLLSLLYFGTFGSF---IGFSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 101 LFTVLIGFTdiLGDTATIITSLFILRFLVGLSESPAFpgnsKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLV- 179
Cdd:COG2223 283 LGLLLLALA--LGSLWLFLVLFLLLGLALGGGNGAVF----ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLd 356
|
170 180 190
....*....|....*....|....*....|
gi 446291608 180 ATVHWQSIFWVMGGLGIIlSFIWLKVIYSP 209
Cdd:COG2223 357 ATGSYTAAFLVFAVLALV-ALVLTLLLYRR 385
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
26-435 |
1.25e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 68.77 E-value: 1.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 26 LAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVL 105
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 106 IGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQ 185
Cdd:cd17365 81 TAF-------AQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 186 SIFWVMGGLGIILsfiwlkviysptnhptvnpeevkyiasegalldmgensqnakkekitwskvkrLLASRMMLGIFIGQ 265
Cdd:cd17365 154 SVFLLGGVPPLIL-----------------------------------------------------LPLLRGTLLLWVTF 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 266 YCVNTLTYFFLTWFPvYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIVVGFL---VST 342
Cdd:cd17365 181 FMGLLLVYLLNSWLP-KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADR---------FGPKRVLALFFAlgaVSL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 343 SIILCNYDDSQAAIVFFMSLSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLAL 422
Cdd:cd17365 251 ALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVF 330
|
410
....*....|...
gi 446291608 423 TYVGVHAIAAVIC 435
Cdd:cd17365 331 LALAIPAALGALA 343
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
53-443 |
7.54e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.85 E-value: 7.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 53 ELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLD----KFGARRVYF-WSLFLWSLFTVLIGFTDILGDTATIITsLFILRF 127
Cdd:COG2211 40 VLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWIlIGAIPLALSFVLLFTAPDLSPTGKLIY-ALVTYL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 128 LVGLSESPAFPGNSKIAAAWFPT-KERGTAAAIFNSSSYFSTVLFAPLMGWLVATV------HWQSIFWVMGGLGIILSF 200
Cdd:COG2211 119 LLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 201 IWLKVIysptnhptvnPEEVKYIASEGALLDMgensqnakkekitwskVKRLLASRMMLGIFIGQYCVNTLTYFFLTWFP 280
Cdd:COG2211 199 LTFFGT----------KERPVPEEEKVSLKES----------------LKALLKNRPFLLLLLAYLLFFLALALVAALLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 281 VYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIVVGFLVSTSIILCNY---DDSQAAIV 357
Cdd:COG2211 253 YYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR---------FGKKKAFIIGLLLAALGLLLLFflgPGNLWLLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 358 FFMSLSFFGKG-IGSLGWAVMSDVAP-------KEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTG-SFNLALTYVGVH 428
Cdd:COG2211 324 VLAALAGIGLGaILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyVAGAAQSPSALT 403
|
410
....*....|....*
gi 446291608 429 AIAAVICYTVIVGKI 443
Cdd:COG2211 404 GIRLLFFLLPAVLLL 418
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
50-321 |
8.69e-12 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 66.44 E-value: 8.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 50 MSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLV 129
Cdd:cd17323 25 IAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL-------APNIAMLIILRFLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 130 GLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLfAPLMG-WLVATVHWQSIFWV---MGGLGIILSFIWLKV 205
Cdd:cd17323 98 GFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPAL-GPIIGgFITQSLGWRWIFWFlaiISGFCLILIFLFLPI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 206 IysptnhptvnpeevkyiasegalldmgensqnakkekitwskvkrllasrMMLGIFIGqyCVNTLTYFFLTWFPVYLVK 285
Cdd:cd17323 177 V--------------------------------------------------LLLGLYVG--LVYAILYLFLTAFPYVFGE 204
|
250 260 270
....*....|....*....|....*....|....*.
gi 446291608 286 ERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIR 321
Cdd:cd17323 205 VYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYR 240
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
52-434 |
9.64e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 66.08 E-value: 9.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 52 HELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGL 131
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL-------ATSVALLLVLRLIHGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 132 SESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVmgglGIILSFIWLKVIYSPTN 211
Cdd:cd17489 97 GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV----AAVLALLALLLVFLVKD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 212 HPTVNPEEvkyiasegalldmgensQNAKKEKITWSKVKR-LLASRMMLGIFIGQYCVntltyffLTWFPVYLvkeRHLS 290
Cdd:cd17489 173 PPPVAAEE-----------------AEAGTRAFRRLVEKKvLPPALILFLASIAYGAI-------STFLPLYA---AERG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 291 ILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIVVGFLVSTSIILCNYdDSQAAIVFFMSLSFFGKGIG 370
Cdd:cd17489 226 ISNAGLFFTVYAIALLLSRPFSGKLSDR---------KGPKTVIIPGLLLLALGLLLLS-FAGSPWMLLLAAVLYGLGFG 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446291608 371 SL---GWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGsfnlaltYVGVHAIAAVI 434
Cdd:cd17489 296 LLfpaLQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-------YRAMFLLAAVV 355
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
22-201 |
1.21e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 65.70 E-value: 1.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 22 RYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSL 101
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 102 FTVLIGFTdILGDTATIITSLFILRFLVGLsespAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVAT 181
Cdd:cd17316 256 LALPLFYL-LSGSPTLLLLLLFILSFFVGG----VWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
|
170 180
....*....|....*....|
gi 446291608 182 VHWQSIFWVMGGLGIILSFI 201
Cdd:cd17316 331 TGGTGVPALILALLAIVALI 350
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
50-439 |
1.14e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 62.98 E-value: 1.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 50 MSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLV 129
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCAL-------ASSIEQLLIARFLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 130 GLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLfAPLMG-WLVATVHWQSIFWVMGGLGIILSFIWLKVIys 208
Cdd:cd17320 98 GLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPAL-APLLGgLLLLFFGWRAIFVFLALLGLLLLLLVLLFL-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 209 ptnhptvnPEEVKYIASEGALLDMGENSQNAKKEKITWSKVkrLLASRMMLGIFIgqycvntltyfFLTWFPVYLVKERH 288
Cdd:cd17320 175 --------PETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYA--LALGLSFAGLFA-----------YLAAAPFIYIEQLG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 289 LSILEAGFAAVAPALCGFVGGILGG-----LTSDKLIRMNYSLSFSrklpIVVGFLVSTSIILcnydDSQAAIVFFMSLS 363
Cdd:cd17320 234 LSPAQFGLLFALNAIALILGSLLNGrlvrrFGPRRLLRLGLLLLLA----AALVLLLAALLGG----LSLWPLVAPLFLI 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446291608 364 FFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYiLASTGSFNLALTYVGVhAIAAVICYTVI 439
Cdd:cd17320 306 FFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGL-LPNGTALPMGLLILVL-GLLALLLLILL 379
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
61-435 |
3.70e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 61.18 E-value: 3.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 61 MGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTDilgDTATIITSLFILRFLVGLSESPAfpgN 140
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP---SIYLFVVLMFLAGLGAGILDTGA---N 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 141 SKIAAAWfpTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATV-HWQSIFWVMGGLGIILSFIWLKVIYSPTNHPTVNPEE 219
Cdd:cd17333 107 TFVGALF--EESSATRLNVLHGFFGLGALIGPLIATSLLTSElSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 220 VkyiasegalldmgeNSQNAKKEKITWSKVKRLLAsrmmLGIFIGQYcvntLTYFFLTWFPVYLVKERHLSILEAGFAAV 299
Cdd:cd17333 185 V--------------GAFSASASRLLRNPSIILGA----LALFLYVG----AETAFSSWVPSYLVEKKHVSDGLAGYLLS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 300 APALCGFVGGILGGLTSDKlirmnysLSFSRKLPIVVGFLVSTSIILCNYDDSQAAIVFFMSLSFFGKGIGSLGWAVMSD 379
Cdd:cd17333 243 GFWVGITIGRLLGGPISRR-------IKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGIS 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 446291608 380 VAPKEmVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLALTYVGVHAIAAVIC 435
Cdd:cd17333 316 NLPYA-KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLA 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
25-204 |
4.38e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.09 E-value: 4.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 25 ILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTV 104
Cdd:cd06173 210 LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 105 LIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHW 184
Cdd:cd06173 290 VLGL-------SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL 362
|
170 180
....*....|....*....|
gi 446291608 185 QSIFWVMGGLGIILSFIWLK 204
Cdd:cd06173 363 SAVFLLAGALLLLAALLLLL 382
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
53-434 |
6.53e-10 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 60.71 E-value: 6.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 53 ELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGLS 132
Cdd:PRK12307 47 DLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGL-------ASGVIMLTLSRFIVGMG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 133 ESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVmgGLGIILSFIWLKviysptnh 212
Cdd:PRK12307 120 MAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFV--GLLPVLLVIYIR-------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 213 pTVNPEEVKYIasEGALLDMGENSQNA-KKEKITWSKVKRLLASRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSI 291
Cdd:PRK12307 190 -ARAPESKEWE--EAKLSGKGKHSQSAwSVFSLSMKGLFNRAQFPLTLCVFIVLFSIFGANWPIFGLLPTYLAGEGFDTG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 292 LEAGFAAVApALCGFVGGILGGLTSDKLirmnySLSFSRKLPIVVGFLVSTSIILCNYDDSQAAIVFFMSLSFFGKGIGS 371
Cdd:PRK12307 267 VVSNLMTAA-AFGTVLGNIVWGLCADRI-----GLKKTFSIGLLMSFLFIFPLFRIPQDNYLLLGACLFGLMATNVGVGG 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446291608 372 LGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGsFNLALTYVGVHAIAAVI 434
Cdd:PRK12307 341 LVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMG-LGAALTFIVAFWTATIL 402
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
53-197 |
2.57e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 58.93 E-value: 2.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 53 ELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGLS 132
Cdd:TIGR00711 31 DLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGV-------APNLELMIIFRVIQGFG 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446291608 133 ESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGII 197
Cdd:TIGR00711 104 GGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGII 168
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
22-323 |
5.02e-09 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 57.80 E-value: 5.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 22 RYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARrvYFWSLFLwsl 101
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPR--YFMGIGL--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 102 ftVLIGFTDILGDTATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVAT 181
Cdd:cd17488 76 --IATGIINILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 182 VHWQSIFWVMGGLGIILSfIWLkvIYSPTNHPtvnpeevKYIasegalldmgensqnakkekitWskvkrLLASRMMLgI 261
Cdd:cd17488 154 YGWRAGMYVPGIIAILMG-IVL--CWRLRDRP-------PYI----------------------W-----LLAFCYVL-V 195
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446291608 262 FIGQYCVNtltyfflTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRMN 323
Cdd:cd17488 196 YVVRTAIN-------DWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGN 250
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-439 |
5.98e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 57.59 E-value: 5.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 29 IFLVTAFNYGdrATLSMAATP-MSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIG 107
Cdd:cd17504 2 ALAALAVMLV--ETMLSPALPtIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 108 FtdilgdtATIITSLFILRFLVGLSeSPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSI 187
Cdd:cd17504 80 F-------APNLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 188 FWVMGGLGIILsfiwlkVIYSPtnhptvnpeevkyiasegaLLDMgensqnakkekitwskvkRLLASRMMLGIFIGQYC 267
Cdd:cd17504 152 FWTAAPVAVLL------AALVP-------------------LIDL------------------RLLRRRNVLLANITALL 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 268 VNTLTYFFLTWFPVYLVKERH----LSILEAGFAAVAPALCGFVGGILGGltsdKLIRmnyslSFSRKLPIVVGFLVST- 342
Cdd:cd17504 189 AGFGMFMVFQLLPQLLQLPTPtgfgLGITEAGLLLLPGALVMLIAGPLAG----RLIA-----RVGPRRVLLIGLVISAv 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 343 -SIILCNYDDSQAAIVFFMSLSFFGKGIGSLGWA-VMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILA------- 413
Cdd:cd17504 260 gLLLLALLHSSLWALVVALLLIGIGLGLAFASLPnIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTtytvsit 339
|
410 420 430
....*....|....*....|....*....|.
gi 446291608 414 -----STGSFNLALTYVGVHAIAAVICYTVI 439
Cdd:cd17504 340 sggvpTEGAYVLAFLIGAALALAALLLSLLI 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
57-437 |
6.47e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 57.63 E-value: 6.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 57 DSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLwSLFTVLIGFTDILGDTATIITsLFILRFLVGLSESPA 136
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLL-RALLAAVLALLALLGSLSLWL-LLVLAFLLGIASAFF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 137 FPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVmGGLGIILSFIWLKVIYSPTNHPTVN 216
Cdd:cd06173 110 GPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI-NALSFLLSALLLLFIRRPPPAAPGE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 217 PEEVKYIASEGALldmgensqnakkekitwskvKRLLASRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGF 296
Cdd:cd06173 189 SSSLLLRDLREGL--------------------RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 297 AAVAPALCGFVGGILGGLTSDKLIRmnyslsfSRKLPIVVGFLVSTSIILCNYDDSQAAIVFFMSLSFFGKGIGSLGWAV 376
Cdd:cd06173 249 LLAAFGVGALLGALLLGRLSKRRRR-------GRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446291608 377 MSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLALTYVGVHAIAAVICYT 437
Cdd:cd06173 322 LQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
53-438 |
1.07e-08 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 56.86 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 53 ELGIDSVTMGYIFsafawAYVIGQIPGGWLLDKFGARrvyfWSLFLWSLFTVLIGFTDILGDTATIITSLFILRFLVGLS 132
Cdd:cd17398 38 DTAVDWTSMIYML-----TYIPLIFPATWLLEKYGLR----VTVLLGSFLNCLGAWLKLFSSSPDLFWVAMAGQTICALA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 133 ESPAFPGNSKIAAAWFPTKERGTAAAI--FNSS------SYFSTVLFAPLMGWLVATVHWQSIFWvmgGLGIILSFIWLK 204
Cdd:cd17398 109 QVFILGIPPRLAAVWFGPDEVSTATAIgvFGNQlgvalgFVLPPLLVPNSENKDEIGKGLSILFY---GVAGICTALFIL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 205 VIYSPTNHPTVNPEEVKYIASEGALLDMGensqnakkekiTWSKVKRLLASR--MML----GIFIGQYCV--NTLTYFFL 276
Cdd:cd17398 186 VIIFFKEKPPIPPSRAQAAAQELRSEDQS-----------YLGSLKRLFKNKgfLLLlityGINTGVYYAisTLLNQMVL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 277 TWFPVYLVkerhlsilEAGFAAVAPALCGFVGGILGGLTSDKLIR------MNYSLSFsrklpivVGFLVSTSIIlcnyD 350
Cdd:cd17398 255 EYFPNEEV--------NAGWIGLTLVIAGLVGSVVAGIWLDKTKKykettiIVYILSF-------IGMVAFTFTL----D 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 351 DSQAAIVFFMS--LSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLALTYVGVH 428
Cdd:cd17398 316 LGSIWVVFLTAgaLGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGALLDKVGALASNIVLSVAL 395
|
410
....*....|
gi 446291608 429 AIAAVICYTV 438
Cdd:cd17398 396 LLGTILTAFI 405
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
55-433 |
3.17e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 55.26 E-value: 3.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 55 GIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTDilgdtatIITSLFILRFLVGLses 134
Cdd:cd17477 27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD-------SPWVWFLLRFVMGI--- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 135 pAFPGNSKIAAAWF----PTKERGTAAAIFNSSSYFSTVLfAPLMGWLVATVHWQsIFWVMGGLgIILSFIWlkVIYSPT 210
Cdd:cd17477 97 -GLAGLFVVSESWLnalaTNENRGRVLGLYSTVLGLGFAL-GPLLLALVGTAGAL-PFLIAAVL-LLLALVP--LLLTRR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 211 NHPTVNPEEvkyiasegalldmgensqnAKKEKITWSKVKRLLASRMMLGIFIGQycvntltyfFLTWFPVYLVkERHLS 290
Cdd:cd17477 171 AAPEIEEAE-------------------SISLRRLLRIAPLALLGAFVAGFLEGA---------FYSLLPLYGL-RLGLS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 291 ILEAGFAAVAPALCGFVGGILGGLTSDKLIRmnyslsfsRKLPIVVGFLVSTSIILCNYDDSQ--AAIVFFMSLSFFGKG 368
Cdd:cd17477 222 VAQAALLLAAFVLGGLLLQWPLGWLADRFDR--------RRVLLGCALLGALAALLLPLVPGLplALLVLLFLWGGAAGP 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446291608 369 IGSLGWAVMSD-VAPKEMVGLSGGMMNAFGnTAGIVTPIVIGYILASTGSFNLALTYVGVHAIAAV 433
Cdd:cd17477 294 LYTLALALAGDrLPGDELVAANAALLLLYG-LGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
22-435 |
3.48e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 55.31 E-value: 3.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 22 RYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSL 101
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 102 FTVLIGFtdilgdtATIITSLFILR-FLVGLSESPAFPGNSKIAAAWFPTKeRGTAAAIFNSSSYFSTVLFAPLMGWLVA 180
Cdd:cd17353 81 GFILSAF-------AISLPLLFLGYgVLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLIN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 181 TVHWQSIFWVMGGLGIILSFIWLKVIYSPTnhPTVNPEEVKyiasegalldmgeNSQNAKKEKITWSKVKRLLASRMMLG 260
Cdd:cd17353 153 TVGVPTTFLILGIIFLIIIVIGAFLIRDPP--KGWVPPGVD-------------PLANNAENSPRDYTPREMLRTPTFWL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 261 IFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRMN-YSLSFsrklpiVVGFL 339
Cdd:cd17353 218 LWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNtLSIAF------LIQGV 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 340 VSTSIILCNydDSQAAIVFFMSLSFFGKGIG-SLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILaSTGSF 418
Cdd:cd17353 292 AMFLLPFIG--SVAVLFVLGVALIGFCYGGGfALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVL-YTGGY 368
|
410
....*....|....*..
gi 446291608 419 NLALTYVGVHAIAAVIC 435
Cdd:cd17353 369 NAAFIIAAALSLVALAL 385
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-205 |
6.20e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.50 E-value: 6.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 25 ILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDK-FGARRVYFWSLFLWSLFT 103
Cdd:cd17474 200 LLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 104 VLIGFTDILgdtatiiTSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVH 183
Cdd:cd17474 280 LLLGFVPSL-------ALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG 352
|
170 180
....*....|....*....|..
gi 446291608 184 WQSIFWVMGGLGIILSFIWLKV 205
Cdd:cd17474 353 LSAPFLVGAAIALAAAVLLALL 374
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
22-323 |
1.78e-07 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 53.18 E-value: 1.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 22 RYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARrvYFWSLFLwsl 101
Cdd:PRK11663 21 RRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNAR--YFMGIGL--- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 102 ftVLIGFTDILGDTATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVAT 181
Cdd:PRK11663 96 --IATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALH 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 182 VHWQSIFWVMGGLGIILS-FIWLKVIYSPTNH--PTVNPEEVkyiasegallDMGENSQNAKKEKITWskvKRLLASRMM 258
Cdd:PRK11663 174 YGWRYGMMIAGIIAIVVGlFLCWRLRDKPQAMglPSVGEWRH----------DALELAQQQEGAGLSR---KEILTKYVL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 259 LGIFIGQYCVN-TLTYFFLT----WFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRMN 323
Cdd:PRK11663 241 LNPYIWLLSFSyVLVYVVRAaindWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGN 310
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
18-323 |
7.25e-07 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 51.25 E-value: 7.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 18 HTKTRYYILAMIFLVTAFNYGDRATLSMAaTPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLF 97
Cdd:PRK11273 23 YRRLRWQIFLGIFFGYAAYYLVRKNFALA-MPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 98 LWSLFTVLIGFTDIlgdTATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPL--- 174
Cdd:PRK11273 102 LAAAVMLFMGFVPW---ATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLfll 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 175 -MGWLvatVHWQSIFWVMGGLGIILS-FIWLKVIYSPTNHPTVNPEEVKYiasegallDMGENSQNAKKEKITWSK--VK 250
Cdd:PRK11273 179 gMAWF---NDWHAALYMPAFAAILVAlFAFAMMRDTPQSCGLPPIEEYKN--------DYPDDYNEKHEQELTAKQifMQ 247
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446291608 251 RLLASRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRMN 323
Cdd:PRK11273 248 YVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGN 320
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
61-439 |
1.90e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 49.48 E-value: 1.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 61 MGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGN 140
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL-------APNMTMLIVGRAIQGIGGGGLMSLA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 141 SKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIwlkviysptnhptvnpeeV 220
Cdd:cd17502 105 FIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALAL------------------L 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 221 KYIASegalldmgensqnakkekitwskvkrllasrMMLGIFIGQYCVNTLTYFfltwFPVYLVKERHLSILEAGFAAVA 300
Cdd:cd17502 167 RTILL-------------------------------SSIFGFLFGGALFGLIYY----LPLYFQLVLGDSATKSGVRLLP 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 301 PALCGFVGGILGGLTSDKLIRMNYSLSFSRKLPiVVGFLVSTSIilcNYDDSQAAIVFFMSLSFFGKGIGSLGWAV-MSD 379
Cdd:cd17502 212 LIIGLVIGSIISGALISKTGRYKPLIVIGTILM-SVGAGLLTTL---TLDTSKWLLIGYLILLGLGLGIGFQQPLVaVQN 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 380 VAPKEMVGLSGGMMNaFGNTAGivtpivigyilastGSFNLALTYVGVHAIAAVICYTVI 439
Cdd:cd17502 288 AVPPADVGVATATNT-FFRSLG--------------GTLGVAITDVFLVALALAALAFLL 332
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
22-434 |
2.00e-06 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 49.72 E-value: 2.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 22 RYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSL 101
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 102 FTVLIGFTDilgdtaTIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKeRGTAAAIFNSSSYFSTVLFAPLMGWLVAT 181
Cdd:cd17314 81 GYTYLSYVF------NSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 182 VHWQSIFWVMGGL-GIILSFIWLKVIYSPTNHPTVNPEEVKYIASEGALLDMgensqnakkekitwsKVKRLLASRMMLg 260
Cdd:cd17314 154 YGLALVYTILGILaAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRD---------------KVFWILFIAIFL- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 261 ifigqycvntltyFFLTWFPVYLVKERHLSILEAGFAAVAP------ALCGFVGGILGGLTSDKLIrmnyslSFSRKLPI 334
Cdd:cd17314 218 -------------VLIGGFLFIANMASLVRSLQLDAPSFVTklmsiyGLFNAFGRLLWGIVADFFG------GRLSTLSI 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 335 VVGFL-VSTSIILCNYDDSQAAIVFFMSLSFFG-KGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYIL 412
Cdd:cd17314 279 LLTILgLGLCAFLFLLKMTPVGLVLTGSLLGFSyGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFY 358
|
410 420
....*....|....*....|...
gi 446291608 413 ASTGSFNLALTYVGV-HAIAAVI 434
Cdd:cd17314 359 DRTPSYISAVYIYAViVFLASAI 381
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
63-207 |
2.02e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 49.50 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 63 YIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSK 142
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAF-------SPSYELFLVLRFLVGVTSAGIFTVGFV 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446291608 143 IAAAWFPTKERgTAAAIFNSSSYFSTVLFAPLMGWLvaTVHWQSIFWVMGGLGIILSFIWLKVIY 207
Cdd:cd17317 102 LGMEIVGPKYR-SFVGILFGLFWALGYMLLALLAYL--IRDWRWLQLAISLPGLLFLLLLWWLPR 163
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
25-201 |
4.15e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 48.71 E-value: 4.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 25 ILAMIFLVTAFNYGdratLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTV 104
Cdd:cd17478 200 LLIIVFLRSWVLSS----LTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 105 LIGFTDILGdtatiitsLFILRFLVGLSESPAFPGNSKIAAAWFPTKeRGTAAAIFNSSSYFSTVLFAPLMGWLVATVHW 184
Cdd:cd17478 276 LFLLTPGIW--------SYILLVLAGFLLFASFPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGL 346
|
170
....*....|....*..
gi 446291608 185 QSIFWVMGGLGIILSFI 201
Cdd:cd17478 347 ESVLLILALLPLLGALL 363
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
17-203 |
4.20e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 48.73 E-value: 4.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 17 KHTKTRYYILAMIFLVTAFnygdRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSL 96
Cdd:cd17320 199 KNRRFLGYALALGLSFAGL----FAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 97 FLWSLFTVLIGFTDILGDTAtiITSLFILRFLVGLSESPAFPGNSKIAAAWFPtKERGTAAAIFNSSSYFSTVLFAPLMG 176
Cdd:cd17320 275 LLLLAAALVLLLAALLGGLS--LWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVG 351
|
170 180
....*....|....*....|....*..
gi 446291608 177 WLVATVHWqSIFWVMGGLGIILSFIWL 203
Cdd:cd17320 352 LLPNGTAL-PMGLLILVLGLLALLLLI 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
261-436 |
4.29e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.57 E-value: 4.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 261 IFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIVVGFLV 340
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---------FGRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 341 S--TSIILCNYDDSQAAIVFFMSLSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSF 418
Cdd:pfam07690 72 FalGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151
|
170
....*....|....*...
gi 446291608 419 NLALTYVGVHAIAAVICY 436
Cdd:pfam07690 152 AAFLILAILSLLAAVLLL 169
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
30-436 |
4.65e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 48.32 E-value: 4.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 30 FLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFT 109
Cdd:cd17352 9 FLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 110 dilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFpTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFW 189
Cdd:cd17352 89 ------TSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 190 VMGGLGIILSFIwlkviysptnhptvnpeevkyiaseGALLdmgensqnakkekitwskvkRLLASRMMLGIFIGqycvN 269
Cdd:cd17352 162 ILGGLCLNLCVC-------------------------GLLL--------------------RLLKDPTFVLLALG----V 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 270 TLTYFFLTWFPVYLV---KERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRMNYSLSFSrkLPIVVGFLVSTSIIL 346
Cdd:cd17352 193 SFAMLGFFVPFVYLPsyaKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIF--TLLILGLSLLAFPLA 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 347 CNYddsQAAIVFFMSLSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLALTYVG 426
Cdd:cd17352 271 TTY---VGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCG 347
|
410
....*....|
gi 446291608 427 VHAIAAVICY 436
Cdd:cd17352 348 ACLLLSGVLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-172 |
8.50e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.80 E-value: 8.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 24 YILAMIFLVTAFNYGdratLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFT 103
Cdd:pfam07690 204 WLLLALLLFGFAFFG----LLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAA 279
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446291608 104 VLIGFTDILGDTATIITSLFIlrflVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFA 172
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALLL----LGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
28-436 |
9.94e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 47.56 E-value: 9.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 28 MIFLVTAFN---YG-DRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFT 103
Cdd:cd17359 1 LISLVAALGgllFGyDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 104 VLIGFTdilGDTATIITSLFILRFLVGLSE--SPAFPgnSKIAaawfPTKERGTAAAIFN-------SSSYFSTVLFAPL 174
Cdd:cd17359 81 LGSAFS---PNFTIFIIARIIGGLAVGGASalVPMYI--AEVA----PAEIRGRLVSLNQlmivfgqLLAYIVNYLIANA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 175 MG--WLVATVhWQSIFWVMGGLGIILSFIWLKViysptnhptvnPEEVKYIASEGalldmgensqnakkekitwskvKRL 252
Cdd:cd17359 152 GGadWLGAEG-WRWMLGLEAIPAILFLLGMLFI-----------PESPRWLVSKG----------------------KPI 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 253 LASRMMLGIFiGQYC-VNTLTYFFLTWFpvylvKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKLIRmnyslsfsRK 331
Cdd:cd17359 198 LIIGIGLAIF-QQFVgINVIFYYGPEIF-----QNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGR--------KP 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 332 LPIV-----VGFLVSTSIILCNYDDSQAA---IVFFMSL--SFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTA- 400
Cdd:cd17359 264 LLLIgsigmAISLLLIGTAFYFAPGSQASgivALVLILLfvAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIAn 343
|
410 420 430
....*....|....*....|....*....|....*....
gi 446291608 401 ---GIVTPIVIgyilastGSFNLALTYvGVHAIAAVICY 436
Cdd:cd17359 344 flvSLTFPILL-------AAFGLAFTF-LIFAVICVLAF 374
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
25-219 |
1.54e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 25 ILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTV 104
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 105 LIGFTDILGdtatiitSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLfAPLMGWLVATVHW 184
Cdd:cd17329 81 LLGFAHSPW-------LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAI-GPLLGGLLLLYSF 152
|
170 180 190
....*....|....*....|....*....|....*
gi 446291608 185 QSIFWVmGGLGIILSFIWLKVIYSPTNHPTVNPEE 219
Cdd:cd17329 153 RLLFLA-AAVLFLLAALVLLFLLPETRPKRRAAEK 186
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
22-203 |
2.46e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.43 E-value: 2.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 22 RYYILAMIFLVTAFNygdrATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSL 101
Cdd:COG2211 231 LLLLLAYLLFFLALA----LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 102 FTVLIGFTDilgdtATIITSLFILRFLVGLSESPAFPGNSKIAA-------AWFPTKERGTAAAIFNSSSYFSTVLFAPL 174
Cdd:COG2211 307 GLLLLFFLG-----PGNLWLLLVLAALAGIGLGAILVLPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGAL 381
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 446291608 175 MGWLVATVHWQS--------------IFWVMGGLGIILSFIWL 203
Cdd:COG2211 382 AGLLLALFGYVAgaaqspsaltgirlLFFLLPAVLLLLAALLL 424
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
21-434 |
2.64e-05 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 46.24 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 21 TRYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWS 100
Cdd:cd17334 1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 101 LFTVLigfTDILGDTATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTvlfapLMGWLVA 180
Cdd:cd17334 81 LGSVL---KCIPLGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGC-----AIGFLLP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 181 TV----------HWQSIFWVMGGLGIILSFIWLKVIYSPTNHPTVNPEEVKYIaSEGALLDMGENSQNAKKEKitwSKVK 250
Cdd:cd17334 153 PVvvpppkgtkkEFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQN-SEHVILELQKSISELLRNE---PFVL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 251 RLLASRMMLGIFIGqycVNTLTYFFLTWFpvylvkerHLSILEAGFAAVAPALCGFVGGILGGLTSD---------KLIR 321
Cdd:cd17334 229 LAVAFSIMMGVFAG---FSSVLAQILLPF--------GVSQTSAGWLGFFGIVAGMVGGLLLGLFVDrtrmfkligLIIL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 322 MNYSLSFSRKLPIVVGFLVSTSIILCnyddsqAAIVFFmsLSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAG 401
Cdd:cd17334 298 ALGTVVCTFFMLLVDRYGLPYVTLAF------YLLCGL--LGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFS 369
|
410 420 430
....*....|....*....|....*....|...
gi 446291608 402 IVTPIVIGYILASTGSFNLALTYVGVHAIAAVI 434
Cdd:cd17334 370 FLLMLVFSELLGPTPTESKYLLWFILCTVGSCL 402
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-201 |
2.85e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 46.27 E-value: 2.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 25 ILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFW-SLFLWSLFT 103
Cdd:cd06174 205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLiGLLLMALGL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 104 VLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVH 183
Cdd:cd06174 285 ALLLL-------APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
170
....*....|....*...
gi 446291608 184 WQSIFWVMGGLGIILSFI 201
Cdd:cd06174 358 GLTGAFLVLAVLLLLAAI 375
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
25-219 |
5.00e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 45.37 E-value: 5.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 25 ILAMIFLVTAFNYGdratlSMAATP----MSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWS 100
Cdd:cd06180 1 LAGALALAVAMGIG-----RFAYTPllplMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 101 LFTVLIGFTDILGdtatiitSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLM-GWLV 179
Cdd:cd06180 76 LLLAAMALTSGFA-------ALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVpAGLG 148
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 446291608 180 ATVHWQSIFWVMGGLGIILSFI-WLKVIYSPTNHPTVNPEE 219
Cdd:cd06180 149 GGLSWRAGWLALALLSAVLLLLsFLLLRRGPSAPTEASAAE 189
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
42-432 |
6.13e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 45.31 E-value: 6.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 42 TLSMAATPMSHELGiDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARrvYFwslFLWSLFTVLIGFtdILGDTATIITS 121
Cdd:cd06179 16 LPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRR--WF---FIGGNLLGVVGS--IVAGTAKSVNM 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 122 LFILRFLVGLSESPAFPGNSkIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVH--WQSIFWVMGGLGiILS 199
Cdd:cd06179 88 LIGGQALIGIGAGTQGLGAA-VASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYINAIFN-ALA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 200 FIWLKVIYSPTNHPTVNPEEVK-------------YIASEGALL---DMGENSQNAKKEKI------------------T 245
Cdd:cd06179 166 LILLFFFYHPPPRPQLHGSSTRqklkrldwvglflLIAGLVLFLlglSWGGNPYPWSSAHViaplviggvlliafglyeW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 246 WSKVKRLLASRMM------LGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKL 319
Cdd:cd06179 246 KGTKDGLLPPRLLfrgrnfALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKI 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 320 IRMNYSLSFSrklpIVVGFLVSTSIILCNYDDSQAAIVFFMSLSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNT 399
Cdd:cd06179 326 KHIKWQLVAG----FVLFTAFLALLALITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARAL 401
|
410 420 430
....*....|....*....|....*....|...
gi 446291608 400 AGIVTPIVIGYILASTGSFNLAlTYVGVHAIAA 432
Cdd:cd06179 402 GGAVGTAIFTSILSNRLSKNLP-ARVAPAALEA 433
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
53-202 |
7.54e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.86 E-value: 7.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 53 ELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTDILGdtatiiTSLFILRFLVGLS 132
Cdd:cd17477 217 RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLP------LALLVLLFLWGGA 290
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 133 ESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIW 202
Cdd:cd17477 291 AGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
25-203 |
8.16e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 8.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 25 ILAMIFLVTAFNYgDRATLSMAAtpmsHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFlwSLFTV 104
Cdd:cd17370 205 YLLAVALFALGNF-SFAFLILRA----QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYL--SLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 105 LIGFTDILGDTATIItsLFILRFL-VGLSESPAfpgnSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVH 183
Cdd:cd17370 278 YLGFALGSSLWLLLL--GFILWGLyMGAQESIE----RAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS 351
|
170 180
....*....|....*....|
gi 446291608 184 WQSIFwVMGGLGIILSFIWL 203
Cdd:cd17370 352 PSAAF-LFSAVLALIALLLL 370
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
24-203 |
2.09e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.34 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 24 YILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIP-GGWLLDKFGARRVYFWSLFLWSLF 102
Cdd:cd17330 175 PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 103 TVLIGFtdilgdtATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATV 182
Cdd:cd17330 255 LLLLPF-------ASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL 327
|
170 180
....*....|....*....|.
gi 446291608 183 HWQSIFWVMGGLgIILSFIWL 203
Cdd:cd17330 328 GPGVPFLLAAGL-LLIALFLL 347
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
53-209 |
2.79e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.08 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 53 ELGIDSVTMGYIFSAFAWayvigqipgGWLLDKFGARRVYFWSLFLWSLFTVLIGFtdilgdtATIITSLFILRFLVGLS 132
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVF---------GYLSDRFGRKKVLLLSTLVTAVSGVLTAF-------SPNYTVFLVFRLLVGMG 193
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446291608 133 ESPAFPGNSKIAAAWFPTKERGTAAaifNSSSYFSTV--LFAPLMGWLVAtvHWQSIFWVMGGLGIILSFIWLKVIYSP 209
Cdd:TIGR00898 194 IGGIWVQAVVLNTEFLPKKQRAIVG---TLIQVFFSLglVLLPLVAYFIP--DWRWLQLAVSLPTFLFFLLSWFVPESP 267
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
55-204 |
3.72e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.69 E-value: 3.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 55 GIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTDILgdtatiiTSLFILRFLVGLSES 134
Cdd:cd17333 231 HVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTL-------VVGLVATALLGLFMA 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 135 PAFPGNSKIAAAWFPtKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIWLK 204
Cdd:cd17333 304 ALFPTILSLGISNLP-YAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
25-201 |
5.74e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 41.99 E-value: 5.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 25 ILAMIFLVTAFNYGdRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLwSLFTV 104
Cdd:PRK03893 278 VMLMVVVLFAFLYS-WPIQALLPTYLKTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLI-SQLLI 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 105 LIGFTdILGDTATIITSLFILRFLVGLSESPAFPgnsKIAAAWFPTKERGTAAA-IFNSSSYFSTVlfAPLMGWLVATVH 183
Cdd:PRK03893 356 IPVFA-IGGANVWVLGLLLFFQQMLGQGISGLLP---KLIGGYFDTEQRAAGLGfTYNVGALGGAL--APILGALIAQRL 429
|
170
....*....|....*...
gi 446291608 184 wqSIFWVMGGLGIILSFI 201
Cdd:PRK03893 430 --DLGTALASLSFSLTFV 445
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
52-201 |
8.32e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.44 E-value: 8.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 52 HELGIDSVTMGYIFSAFAWAYVIGQIPGGWLL-DKFGARRVYFWSLFLWSLFTVLIGFTdilgdtaTIITSLFILRFLVG 130
Cdd:cd17490 223 KQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFA-------PNLTLLYLLQALNG 295
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446291608 131 LSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFI 201
Cdd:cd17490 296 FGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAIL 366
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
5-203 |
8.86e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 8.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 5 QTNIAVVTQQRAKHTKTRYYILAMIFLVTAFNYgdrATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLD 84
Cdd:cd17473 182 SAASPGAATAAALPWKRVLPIYFLAFLAMLLFY---VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKR 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 85 KFGARRVYFWSLFLWSLFTVLIGftdilgdTATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSS 164
Cdd:cd17473 259 RLGKRRLLAIGFALMALGFLLLA-------LASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAF 331
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 446291608 165 YF----STVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIWL 203
Cdd:cd17473 332 FLgqflSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
50-313 |
1.05e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.22 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 50 MSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTDIlgdtatiITSLFILRFLV 129
Cdd:TIGR00710 31 IAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNN-------IETLLVLRFVQ 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 130 GLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIWLKVIysp 209
Cdd:TIGR00710 104 AFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFIL--- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 210 tnhPTVNPEEVKYIASegalldmgensqnakkekITWSKVKRLLASRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHL 289
Cdd:TIGR00710 181 ---PETLPYEARIQIS------------------TYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGV 239
|
250 260
....*....|....*....|....
gi 446291608 290 SILEAGFAAVAPALCGFVGGILGG 313
Cdd:TIGR00710 240 SPSVFGLLFALNIIAMIFGGFLNG 263
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
57-436 |
1.46e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 40.72 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 57 DSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTDILGDTATIITSLFILRFLVGLSE--S 134
Cdd:pfam00083 44 LSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASvlA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 135 PAFPgnSKIAaawfPTKERGTAAAIFNSSSYFSTvLFAPLMGWLVAT----VHWQSIFWVMGGLGIILSFIWLKVIYSP- 209
Cdd:pfam00083 124 PMYI--SEIA----PKKLRGALGSLYQLAITFGI-LLAYIFGLGLNKtsnsDGWRIPLGLQLVPALLLIIGLLFLPESPr 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 210 ------------------TNHPTVNPEEVKYIASEGALLDMGENSqnAKKEKITWSKVKRLLASRMMLgiFIGQYCvntl 271
Cdd:pfam00083 197 wlvekgrleearevlaklRGVPDVDRELDEIKDSLEAGQEAEKAS--WKELFSTKTRRQRLLIGVMLQ--IFQQLT---- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 272 TYFFLTWFPVYLVKERHLS---ILEAGFAAVapalcGFVGGILGGLTSDKlirmnyslsFSRKLPIVVGFLVST--SIIL 346
Cdd:pfam00083 269 GINAIFYYSTTIFENLGLSdsfLVTIIVGVV-----NFVFTFIAIFLVDR---------FGRRPLLLLGAAGMAicFVIL 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 347 C---------NYDDSQAAIVFFMS-LSFFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTG 416
Cdd:pfam00083 335 GivallgvskSDWAGIVAIVFIALfIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIG 414
|
410 420
....*....|....*....|
gi 446291608 417 SFNLALTYVGVHAIAAVICY 436
Cdd:pfam00083 415 LGYTFFIFAGLLVLFIIFVF 434
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
62-188 |
1.59e-03 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 40.43 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 62 GYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGftdiLGDTATIITslfILRFLVGLSESPAFPGNS 141
Cdd:PRK12382 252 GFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLW----LAPTAWVAL---AGAALTGAGCSLIFPALG 324
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 446291608 142 KIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIF 188
Cdd:PRK12382 325 VEVVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVF 371
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
50-188 |
2.02e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 40.44 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 50 MSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDK-FGARRVYFWSLFLWSLFTVLIGFTDIL-GDTATIITSLFILRF 127
Cdd:TIGR00881 243 LTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKlFNGRRGPLAVFFMALIIVSLLVYWLNPaANPLMDLICLFALGF 322
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446291608 128 LVGLSESPAfpgnSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIF 188
Cdd:TIGR00881 323 LVYGPQMLI----GVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
21-166 |
3.20e-03 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 39.59 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 21 TRYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWS 100
Cdd:cd17397 1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPAFGWSDSDIALLANWGPIGFVPTFFFMAWLMDVKGLRIAVLSSAFLVA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446291608 101 LFTVLIGFTdILGDTATIItsLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSSSYF 166
Cdd:cd17397 81 AGTGLRCIP-VPNHLATWL--IHIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYL 143
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
49-206 |
3.42e-03 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 39.35 E-value: 3.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 49 PMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGFTDILGDTATIITSLFiLRFL 128
Cdd:cd17422 208 PLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIF-YGFM 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446291608 129 VGLSESPAFPgnsKIAAAWFPTKER-GTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIWLKVI 206
Cdd:cd17422 287 FGTVAGTHIP---LLAEDDVVGIEKmSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALV 362
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
53-433 |
5.94e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.74 E-value: 5.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 53 ELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARrvyfWSLFLWSLFTVLIGFtdILGdTATIITSLFILRF-LVGL 131
Cdd:cd17331 29 KLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPR----AALVLSFLSSALSYL--LLA-FASSVPMLFLSRLpSVFM 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 132 SespAFPGNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLFAPLMGWLVATVHWQSIFWVMGGLGIILSFIWLKVIYSPTN 211
Cdd:cd17331 102 H---AMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 212 HPTVNPEEVKyiASEGALLDMGENSQNAKKeKITWSKVKRLLASRMMLGIFIGQycvntltyffltwFPVYLVKERHLSI 291
Cdd:cd17331 179 SKREKEAKES--ASPPSVFNLKEILRLLRL-PGVAFLLLVKLLSGLPIGMFQSM-------------FSLVAMDFFGLTP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 292 LEAG----FAAVAPALC-GFVGGILGGLTSDKLIrMNYSLSFsrklpIVVGFLvstsiILCNYDDSQAAIVFFMSLSFFG 366
Cdd:cd17331 243 EENGylmsYAGVLGMVVqGLLVGPLTKRFGERSL-LKLSVAL-----LAIGYL-----LLAFVTTVWQLLVLLLPLVIGG 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446291608 367 KGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILASTGSFNLALTYVGVHAIAAV 433
Cdd:cd17331 312 SVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTV 378
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
22-110 |
6.45e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.60 E-value: 6.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 22 RYYILAMIFLVTAFNYGD--RATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLW 99
Cdd:COG2270 235 RRYRDLLRFLLAYFFYRDgvQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIW 314
|
90
....*....|.
gi 446291608 100 SLFTVLIGFTD 110
Cdd:COG2270 315 IVVCLAAYFLT 325
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
256-439 |
6.94e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 6.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 256 RMMLGIFIGQYCVNTLTYFFLTWFPvYLVKERHLSILEAGFAAVAPALCGFVGGILGGLTSDKlirmnyslsFSRKLPIV 335
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR---------FGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 336 VGFLVST-SIILCNYDDSQAAIVFFMSLS-FFGKGIGSLGWAVMSDVAPKEMVGLSGGMMNAFGNTAGIVTPIVIGYILA 413
Cdd:COG2814 80 LGLLLFAlGSLLCALAPSLWLLLAARFLQgLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180
....*....|....*....|....*.
gi 446291608 414 STGSFNLALTYVGVHAIAAVICYTVI 439
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
53-205 |
6.94e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 38.36 E-value: 6.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 53 ELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGftdilgdTATIITSLFILRFLVGLS 132
Cdd:PRK11102 20 DFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACA-------LAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 133 ESPAFPGNSKIAAAWFPTKErgtaaaiFNSSSYFSTVLF--APLM-----GWLVATVHWQSIFWVMGGLGIILSF-IWLK 204
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEE-------FSRMMSFVTLVMtiAPLLapiigGWLLVWFSWHAIFWVLALAAILAAAlVFFF 165
|
.
gi 446291608 205 V 205
Cdd:PRK11102 166 I 166
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
61-319 |
7.26e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 38.45 E-value: 7.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 61 MGYIFSAFAWAYVIGQIPGGWLLDKFGARRVYFWSLFLWSLFTVLIGftdiLGDTATIITSLF--ILRFLVGLSESPAFP 138
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFG----LGYYWNIHSLWYfvVVQILAGLFQSTGWP 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 139 GNSKIAAAWFPTKERGTAAAIFNSSSYFSTVLfaplmGWLVATvHWQSIFW---------VMGGLGIIlsfIWLKVIYSP 209
Cdd:cd17344 140 SVVACVGNWFGKGKRGLIMGIWNSHTSVGNIL-----GSLIAG-IFVSSAWglsfivpgiIIAAMGVL---VFLFLVEHP 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 210 tnhPTVnpeevkyiasegalldmgensqnakkekITWSkvkrllasrmmLGIFIGQYcvntLTYFFLTWFPVYLVKERHL 289
Cdd:cd17344 211 ---PGV----------------------------IEFS-----------LCLFFAKL----VSYTFLYWLPLYISNTAIL 244
|
250 260 270
....*....|....*....|....*....|
gi 446291608 290 SILEAGFAAVAPALCGFVGGILGGLTSDKL 319
Cdd:cd17344 245 SAKKAGDLSTLFDVGGIVGGILAGYISDYT 274
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
11-163 |
8.43e-03 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 38.49 E-value: 8.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 11 VTQQRAKHTKTRYYILAMIFLVTAFNYGDRATLSMAATPMSHELGIDSVTMGYIFSAFAWAYVIGQIPGGWLLDKFGARR 90
Cdd:PRK09556 16 LEVQRKMWFKPFMQSYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQ 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446291608 91 VYFWSLFLWSLFTVLIGFtdILGDTATIITSLFILRFLVGLSESPAFPGNSKIAAAWFPTKERGTAAAIFNSS 163
Cdd:PRK09556 96 FLPFLLILSAICMLGFGA--SLGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNIS 166
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
246-392 |
9.32e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 38.02 E-value: 9.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446291608 246 WSKVKRLLASRMMLGIFIGQYCVNTLTYFFLTWFPVYLVKERHLSILeagfAAVAPALCGFVGGILGGLTSDKLIRmnys 325
Cdd:cd17360 181 WPSTRRALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIW----LSLIVAGTNFIFTIVGMYLIDKFGR---- 252
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446291608 326 lsfsRKLPIVVGFLVSTSIILCnyddsqAAIVFFMSL----SFFGKGIGSLGWAVMSDVAPKEMVGLSGGM 392
Cdd:cd17360 253 ----RKLLLISLFGVIVALVVL------AVWLALVGLilylAFFAPGMGPVPWTVNSEIYPLWARGTGGGC 313
|
|
| |
