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Conserved domains on  [gi|446294387|ref|WP_000372242|]
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MULTISPECIES: glutamate decarboxylase [Enterobacteriaceae]

Protein Classification

glutamate decarboxylase( domain architecture ID 10019990)

glutamate decarboxylase converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glu-decarb-GAD TIGR01788
glutamate decarboxylase; This model represents the pyridoxal phosphate-dependent glutamate ...
16-449 0e+00

glutamate decarboxylase; This model represents the pyridoxal phosphate-dependent glutamate (alpha) decarboxylase found in bacteria (low and hi-GC gram positive, proteobacteria and cyanobacteria), plants, fungi and at least one archaon (Methanosarcina). The product of the enzyme is gamma-aminobutyrate (GABA).


:

Pssm-ID: 130848  Cd Length: 431  Bit Score: 806.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387   16 SRFGAKAISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAA 95
Cdd:TIGR01788   1 SAYGSRAVSTGIPKYRMPEEEMPPDAAYQLIHDELSLDGNPRLNLATFVTTWMEPEARKLMDETINKNMIDKDEYPQTAE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387   96 IDLRCVNMVADLWHAPApKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGP-VQICWHKFARYWD 174
Cdd:TIGR01788  81 IENRCVNMLADLWHAPA-KDAEAVGTSTIGSSEAIMLGGLAMKWRWRKRMEAAGKPTDKPNLVMGSnVQVCWEKFARYFD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  175 VELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFV 254
Cdd:TIGR01788 160 VELREVPMDPGRYVIDPEQVVEAVDENTIGVVCILGTTYTGEYEDVKALNDALDEYNAKTGWDIPIHVDAASGGFIAPFV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  255 APDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRL 334
Cdd:TIGR01788 240 YPDLEWDFRLPRVKSINVSGHKYGLVYPGVGWVIWRDEEALPEELIFHVNYLGGDEPTFTLNFSRPANQVIAQYYNFLRL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  335 GREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGrpdEGIPAVCFKLKEGEDPGYTLYDLSERLRLRGWQVPAFTLGGE 414
Cdd:TIGR01788 320 GREGYRKIMQNSLDVARYLAEEIAKLGPFEIISDG---SGIPLVAFKLKDDADPGYTLYDLSHRLRERGWIVPAYTLPKN 396
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 446294387  415 ATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLS 449
Cdd:TIGR01788 397 AEDIVVMRIVVREGFSRDLAELLIEDIEAALAYLE 431
 
Name Accession Description Interval E-value
Glu-decarb-GAD TIGR01788
glutamate decarboxylase; This model represents the pyridoxal phosphate-dependent glutamate ...
16-449 0e+00

glutamate decarboxylase; This model represents the pyridoxal phosphate-dependent glutamate (alpha) decarboxylase found in bacteria (low and hi-GC gram positive, proteobacteria and cyanobacteria), plants, fungi and at least one archaon (Methanosarcina). The product of the enzyme is gamma-aminobutyrate (GABA).


Pssm-ID: 130848  Cd Length: 431  Bit Score: 806.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387   16 SRFGAKAISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAA 95
Cdd:TIGR01788   1 SAYGSRAVSTGIPKYRMPEEEMPPDAAYQLIHDELSLDGNPRLNLATFVTTWMEPEARKLMDETINKNMIDKDEYPQTAE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387   96 IDLRCVNMVADLWHAPApKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGP-VQICWHKFARYWD 174
Cdd:TIGR01788  81 IENRCVNMLADLWHAPA-KDAEAVGTSTIGSSEAIMLGGLAMKWRWRKRMEAAGKPTDKPNLVMGSnVQVCWEKFARYFD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  175 VELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFV 254
Cdd:TIGR01788 160 VELREVPMDPGRYVIDPEQVVEAVDENTIGVVCILGTTYTGEYEDVKALNDALDEYNAKTGWDIPIHVDAASGGFIAPFV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  255 APDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRL 334
Cdd:TIGR01788 240 YPDLEWDFRLPRVKSINVSGHKYGLVYPGVGWVIWRDEEALPEELIFHVNYLGGDEPTFTLNFSRPANQVIAQYYNFLRL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  335 GREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGrpdEGIPAVCFKLKEGEDPGYTLYDLSERLRLRGWQVPAFTLGGE 414
Cdd:TIGR01788 320 GREGYRKIMQNSLDVARYLAEEIAKLGPFEIISDG---SGIPLVAFKLKDDADPGYTLYDLSHRLRERGWIVPAYTLPKN 396
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 446294387  415 ATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLS 449
Cdd:TIGR01788 397 AEDIVVMRIVVREGFSRDLAELLIEDIEAALAYLE 431
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
33-383 2.37e-142

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 412.58  E-value: 2.37e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387   33 PLHEMR-DDVAFQIIND-ELYLDGNARQNLATFCQTWDDENVHKLMD--------------LSINKNWIDKEEYPQSAAI 96
Cdd:pfam00282   1 PGYLKPlLPLAAPIIPEpELQIDGDIRRNLMPGVTTWHSPHFHAYMPtgnsypsllgdmltDAINCNGFTWESSPACTEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387   97 DLRCVNMVADLWHAPAPKNGQ-AVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKP------TDKPNLVCGP-VQICWHK 168
Cdd:pfam00282  81 ENVVMNWLGEMLGLPAEFLGQeGGGVLQPGSSESNLLALLAARTKWIKRMKAAGKPadssgiLAKLVAYTSDqAHSSIEK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  169 FARYWDVELREIPMRPG--QLFMDPKRMIEACDENTI---GVVPTFGVTYTGNYEFPQPLHDALDKfqadtgIDIDMHID 243
Cdd:pfam00282 161 AALYGGVKLREIPSDDNgkMRGMDLEKAIEEDKENGLipfFVVATLGTTGSGAFDDLQELGDICAK------HNLWLHVD 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  244 AASGG--FLAPFVAPdivWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLG-----GQIGTFAIN 316
Cdd:pfam00282 235 AAYGGsaFICPEFRH---WLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGhtdsaYDTGHKQIP 311
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446294387  317 FSRpaGQVIAQYYEFLR-LGREGYTKVQNASYQVAAYLADEIAKLGPYEfICTgrpDEGIPAVCFKLK 383
Cdd:pfam00282 312 LSR--RFRILKLWFVIRsLGVEGLQNQIRRHVELAQYLEALIRKDGRFE-ICA---EVGLGLVCFRLK 373
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
59-444 5.74e-116

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 344.19  E-value: 5.74e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  59 NLATFCQTWDDEnVHKLMDLSINKNWIDK--EEYPQSAAIDLRCVNMVADLWHAPapkNGQAVGTNTIGSSEACMLGGMA 136
Cdd:cd06450    1 FLAGFVTTMDPP-ALLLEMLTSAKNAIDFtwDESPAATEMEAEVVNWLAKLFGLP---SEDADGVFTSGGSESNLLALLA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 137 MKWRWRKRMEAAG-KPTDKPNLVCGP-VQICWHKFARYWDVELREIPMRPGQlFMDPKRMIEACDE------NTIGVVPT 208
Cdd:cd06450   77 ARDRARKRLKAGGgRGIDKLVIVCSDqAHVSVEKAAAYLDVKVRLVPVDEDG-RMDPEALEAAIDEdkaeglNPIMVVAT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 209 FGVTYTGNYEFPQPLHDALDKFqadtgiDIDMHIDAASGGFLAPFVAPDIvWDFRLPRVKSISASGHKFGLAPLGCGWVI 288
Cdd:cd06450  156 AGTTDTGAIDPLEEIADLAEKY------DLWLHVDAAYGGFLLPFPEPRH-LDFGIERVDSISVDPHKYGLVPLGCSAVL 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 289 WRdeealpqelvfnvdylggqigtfainfsrpagqVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFIct 368
Cdd:cd06450  229 VR---------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELL-- 273
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446294387 369 grPDEGIPAVCFKLKEGEDPGYTLYDLSERLRLRG-WQVPAFTLGgeatDIVVMRIMCRRGF-EMDFAELLLEDYKAS 444
Cdd:cd06450  274 --GEPNLSLVCFRLKPSVKLDELNYDLSDRLNERGgWHVPATTLG----GPNVLRFVVTNPLtTRDDADALLEDIERA 345
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
31-446 2.08e-101

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 311.00  E-value: 2.08e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  31 RFPLHEMRDDVAFQIINDELY---LDGNARQNLATF-CQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVAD 106
Cdd:COG0076   39 PLPEEGLPPEEALAELEDLVLpgsVDWNHPRFLAFVtGGTTPAALAADLLASALNQNMGDWDTSPAATELEREVVRWLAD 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 107 LWHAPApkngQAVGTNTIGSSEACMLGGMAMKWRWRKRM-EAAG-KPTDKPNLVCGP-VQICWHKFARYWDVE---LREI 180
Cdd:COG0076  119 LLGLPE----GAGGVFTSGGTEANLLALLAARDRALARRvRAEGlPGAPRPRIVVSEeAHSSVDKAARLLGLGrdaLRKV 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 181 PMrPGQLFMDPKRMIEACDE------NTIGVVPTFGVTYTGNYEfpqPLhDALDKFQADTGIDidMHIDAASGGFLAPfv 254
Cdd:COG0076  195 PV-DEDGRMDPDALEAAIDEdraaglNPIAVVATAGTTNTGAID---PL-AEIADIAREHGLW--LHVDAAYGGFALP-- 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 255 APDIVWDF-RLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQ------IGTFAINFSRPAgQVIAQ 327
Cdd:COG0076  266 SPELRHLLdGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFHASYLGPAddgvpnLGDYTLELSRRF-RALKL 344
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 328 YYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICtgrpDEGIPAVCFKLKEGEDP--GYTLYDLSERLRLRGwq 405
Cdd:COG0076  345 WATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLA----PPELNIVCFRYKPAGLDeeDALNYALRDRLRARG-- 418
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 446294387 406 vPAFTLGGEATDIVVMRIMCRRGF-EMDFAELLLEDYKASLK 446
Cdd:COG0076  419 -RAFLSPTKLDGRVVLRLVVLNPRtTEDDVDALLDDLREAAA 459
PRK02769 PRK02769
histidine decarboxylase; Provisional
50-361 4.40e-11

histidine decarboxylase; Provisional


Pssm-ID: 235068 [Multi-domain]  Cd Length: 380  Bit Score: 64.29  E-value: 4.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  50 LYLDGNARQNLA-TFCQTWDDENVHKLMDLSINK--NWIDKEEYP-QSAAIDLRCVNMVADLWHAPApknGQAVGTNTIG 125
Cdd:PRK02769  16 LYLRHNQYFNVGyPEAADFDYSALKRFFSFSINNcgDPYSKSNYPlNSFDFERDVMNFFAELFKIPF---NESWGYITNG 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 126 SSEACMLGgmamKWRWRKRMEAA----GKPTdkpnlvcgpvQICWHKFARYWDVELREIPMRP-GQlfMDPKRMIEACDE 200
Cdd:PRK02769  93 GTEGNLYG----CYLARELFPDGtlyySKDT----------HYSVSKIARLLRIKSRVITSLPnGE--IDYDDLISKIKE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 201 NTIG---VVPTFGVTYTGNYEFPQPLHDALDKFQADtgiDIDMHIDAASGGFLAPFVAPDIVWDFRLPrVKSISASGHKF 277
Cdd:PRK02769 157 NKNQppiIFANIGTTMTGAIDNIKEIQEILKKIGID---DYYIHADAALSGMILPFVNNPPPFSFADG-IDSIAISGHKF 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 278 GLAPLGCGWVIWRDEEAlpQELVFNVDYLGGQIGTfaINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEI 357
Cdd:PRK02769 233 IGSPMPCGIVLAKKKYV--ERISVDVDYIGSRDQT--ISGSRNGHTALLLWAAIRSLGSKGLRQRVQHCLDMAQYAVDRL 308

                 ....
gi 446294387 358 AKLG 361
Cdd:PRK02769 309 QANG 312
 
Name Accession Description Interval E-value
Glu-decarb-GAD TIGR01788
glutamate decarboxylase; This model represents the pyridoxal phosphate-dependent glutamate ...
16-449 0e+00

glutamate decarboxylase; This model represents the pyridoxal phosphate-dependent glutamate (alpha) decarboxylase found in bacteria (low and hi-GC gram positive, proteobacteria and cyanobacteria), plants, fungi and at least one archaon (Methanosarcina). The product of the enzyme is gamma-aminobutyrate (GABA).


Pssm-ID: 130848  Cd Length: 431  Bit Score: 806.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387   16 SRFGAKAISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAA 95
Cdd:TIGR01788   1 SAYGSRAVSTGIPKYRMPEEEMPPDAAYQLIHDELSLDGNPRLNLATFVTTWMEPEARKLMDETINKNMIDKDEYPQTAE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387   96 IDLRCVNMVADLWHAPApKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGP-VQICWHKFARYWD 174
Cdd:TIGR01788  81 IENRCVNMLADLWHAPA-KDAEAVGTSTIGSSEAIMLGGLAMKWRWRKRMEAAGKPTDKPNLVMGSnVQVCWEKFARYFD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  175 VELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFV 254
Cdd:TIGR01788 160 VELREVPMDPGRYVIDPEQVVEAVDENTIGVVCILGTTYTGEYEDVKALNDALDEYNAKTGWDIPIHVDAASGGFIAPFV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  255 APDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRL 334
Cdd:TIGR01788 240 YPDLEWDFRLPRVKSINVSGHKYGLVYPGVGWVIWRDEEALPEELIFHVNYLGGDEPTFTLNFSRPANQVIAQYYNFLRL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  335 GREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGrpdEGIPAVCFKLKEGEDPGYTLYDLSERLRLRGWQVPAFTLGGE 414
Cdd:TIGR01788 320 GREGYRKIMQNSLDVARYLAEEIAKLGPFEIISDG---SGIPLVAFKLKDDADPGYTLYDLSHRLRERGWIVPAYTLPKN 396
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 446294387  415 ATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLS 449
Cdd:TIGR01788 397 AEDIVVMRIVVREGFSRDLAELLIEDIEAALAYLE 431
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
33-383 2.37e-142

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 412.58  E-value: 2.37e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387   33 PLHEMR-DDVAFQIIND-ELYLDGNARQNLATFCQTWDDENVHKLMD--------------LSINKNWIDKEEYPQSAAI 96
Cdd:pfam00282   1 PGYLKPlLPLAAPIIPEpELQIDGDIRRNLMPGVTTWHSPHFHAYMPtgnsypsllgdmltDAINCNGFTWESSPACTEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387   97 DLRCVNMVADLWHAPAPKNGQ-AVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKP------TDKPNLVCGP-VQICWHK 168
Cdd:pfam00282  81 ENVVMNWLGEMLGLPAEFLGQeGGGVLQPGSSESNLLALLAARTKWIKRMKAAGKPadssgiLAKLVAYTSDqAHSSIEK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  169 FARYWDVELREIPMRPG--QLFMDPKRMIEACDENTI---GVVPTFGVTYTGNYEFPQPLHDALDKfqadtgIDIDMHID 243
Cdd:pfam00282 161 AALYGGVKLREIPSDDNgkMRGMDLEKAIEEDKENGLipfFVVATLGTTGSGAFDDLQELGDICAK------HNLWLHVD 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  244 AASGG--FLAPFVAPdivWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLG-----GQIGTFAIN 316
Cdd:pfam00282 235 AAYGGsaFICPEFRH---WLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGhtdsaYDTGHKQIP 311
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446294387  317 FSRpaGQVIAQYYEFLR-LGREGYTKVQNASYQVAAYLADEIAKLGPYEfICTgrpDEGIPAVCFKLK 383
Cdd:pfam00282 312 LSR--RFRILKLWFVIRsLGVEGLQNQIRRHVELAQYLEALIRKDGRFE-ICA---EVGLGLVCFRLK 373
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
59-444 5.74e-116

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 344.19  E-value: 5.74e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  59 NLATFCQTWDDEnVHKLMDLSINKNWIDK--EEYPQSAAIDLRCVNMVADLWHAPapkNGQAVGTNTIGSSEACMLGGMA 136
Cdd:cd06450    1 FLAGFVTTMDPP-ALLLEMLTSAKNAIDFtwDESPAATEMEAEVVNWLAKLFGLP---SEDADGVFTSGGSESNLLALLA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 137 MKWRWRKRMEAAG-KPTDKPNLVCGP-VQICWHKFARYWDVELREIPMRPGQlFMDPKRMIEACDE------NTIGVVPT 208
Cdd:cd06450   77 ARDRARKRLKAGGgRGIDKLVIVCSDqAHVSVEKAAAYLDVKVRLVPVDEDG-RMDPEALEAAIDEdkaeglNPIMVVAT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 209 FGVTYTGNYEFPQPLHDALDKFqadtgiDIDMHIDAASGGFLAPFVAPDIvWDFRLPRVKSISASGHKFGLAPLGCGWVI 288
Cdd:cd06450  156 AGTTDTGAIDPLEEIADLAEKY------DLWLHVDAAYGGFLLPFPEPRH-LDFGIERVDSISVDPHKYGLVPLGCSAVL 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 289 WRdeealpqelvfnvdylggqigtfainfsrpagqVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFIct 368
Cdd:cd06450  229 VR---------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELL-- 273
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446294387 369 grPDEGIPAVCFKLKEGEDPGYTLYDLSERLRLRG-WQVPAFTLGgeatDIVVMRIMCRRGF-EMDFAELLLEDYKAS 444
Cdd:cd06450  274 --GEPNLSLVCFRLKPSVKLDELNYDLSDRLNERGgWHVPATTLG----GPNVLRFVVTNPLtTRDDADALLEDIERA 345
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
31-446 2.08e-101

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 311.00  E-value: 2.08e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  31 RFPLHEMRDDVAFQIINDELY---LDGNARQNLATF-CQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVAD 106
Cdd:COG0076   39 PLPEEGLPPEEALAELEDLVLpgsVDWNHPRFLAFVtGGTTPAALAADLLASALNQNMGDWDTSPAATELEREVVRWLAD 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 107 LWHAPApkngQAVGTNTIGSSEACMLGGMAMKWRWRKRM-EAAG-KPTDKPNLVCGP-VQICWHKFARYWDVE---LREI 180
Cdd:COG0076  119 LLGLPE----GAGGVFTSGGTEANLLALLAARDRALARRvRAEGlPGAPRPRIVVSEeAHSSVDKAARLLGLGrdaLRKV 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 181 PMrPGQLFMDPKRMIEACDE------NTIGVVPTFGVTYTGNYEfpqPLhDALDKFQADTGIDidMHIDAASGGFLAPfv 254
Cdd:COG0076  195 PV-DEDGRMDPDALEAAIDEdraaglNPIAVVATAGTTNTGAID---PL-AEIADIAREHGLW--LHVDAAYGGFALP-- 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 255 APDIVWDF-RLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQ------IGTFAINFSRPAgQVIAQ 327
Cdd:COG0076  266 SPELRHLLdGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFHASYLGPAddgvpnLGDYTLELSRRF-RALKL 344
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 328 YYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICtgrpDEGIPAVCFKLKEGEDP--GYTLYDLSERLRLRGwq 405
Cdd:COG0076  345 WATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLA----PPELNIVCFRYKPAGLDeeDALNYALRDRLRARG-- 418
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 446294387 406 vPAFTLGGEATDIVVMRIMCRRGF-EMDFAELLLEDYKASLK 446
Cdd:COG0076  419 -RAFLSPTKLDGRVVLRLVVLNPRtTEDDVDALLDDLREAAA 459
PRK02769 PRK02769
histidine decarboxylase; Provisional
50-361 4.40e-11

histidine decarboxylase; Provisional


Pssm-ID: 235068 [Multi-domain]  Cd Length: 380  Bit Score: 64.29  E-value: 4.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387  50 LYLDGNARQNLA-TFCQTWDDENVHKLMDLSINK--NWIDKEEYP-QSAAIDLRCVNMVADLWHAPApknGQAVGTNTIG 125
Cdd:PRK02769  16 LYLRHNQYFNVGyPEAADFDYSALKRFFSFSINNcgDPYSKSNYPlNSFDFERDVMNFFAELFKIPF---NESWGYITNG 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 126 SSEACMLGgmamKWRWRKRMEAA----GKPTdkpnlvcgpvQICWHKFARYWDVELREIPMRP-GQlfMDPKRMIEACDE 200
Cdd:PRK02769  93 GTEGNLYG----CYLARELFPDGtlyySKDT----------HYSVSKIARLLRIKSRVITSLPnGE--IDYDDLISKIKE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 201 NTIG---VVPTFGVTYTGNYEFPQPLHDALDKFQADtgiDIDMHIDAASGGFLAPFVAPDIVWDFRLPrVKSISASGHKF 277
Cdd:PRK02769 157 NKNQppiIFANIGTTMTGAIDNIKEIQEILKKIGID---DYYIHADAALSGMILPFVNNPPPFSFADG-IDSIAISGHKF 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 278 GLAPLGCGWVIWRDEEAlpQELVFNVDYLGGQIGTfaINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEI 357
Cdd:PRK02769 233 IGSPMPCGIVLAKKKYV--ERISVDVDYIGSRDQT--ISGSRNGHTALLLWAAIRSLGSKGLRQRVQHCLDMAQYAVDRL 308

                 ....
gi 446294387 358 AKLG 361
Cdd:PRK02769 309 QANG 312
PLN02263 PLN02263
serine decarboxylase
240-361 2.39e-09

serine decarboxylase


Pssm-ID: 177904 [Multi-domain]  Cd Length: 470  Bit Score: 59.44  E-value: 2.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 240 MHIDAASGGFLAPFV--APDIVwdFRLPrVKSISASGHKFGLAPLGCGWVIWRDEEAlpQELVFNVDYLGGQIGTfaINF 317
Cdd:PLN02263 266 IHCDGALFGLMMPFVkrAPKVT--FKKP-IGSVSVSGHKFVGCPMPCGVQITRMEHI--NVLSSNVEYLASRDAT--IMG 338
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446294387 318 SRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLG 361
Cdd:PLN02263 339 SRNGHAPIFLWYTLNRKGYRGFQKEVQKCLRNAHYLKDRLREAG 382
PLN03032 PLN03032
serine decarboxylase; Provisional
240-361 1.05e-06

serine decarboxylase; Provisional


Pssm-ID: 166673 [Multi-domain]  Cd Length: 374  Bit Score: 50.59  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446294387 240 MHIDAASGGFLAPFV--APDIVwdFRLPrVKSISASGHKFGLAPLGCGWVIWRDEEAlpQELVFNVDYLGGQIGTfaINF 317
Cdd:PLN03032 199 IHCDGALFGLMMPFVsrAPEVT--FRKP-IGSVSVSGHKFLGCPMPCGVALTRKKHV--KALSQNVEYLNSRDAT--IMG 271
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446294387 318 SRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLG 361
Cdd:PLN03032 272 SRNGHAPLYLWYTLRRKGYRGIKRDVQHCMRNAHYLKDRLTEAG 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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