|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
1-438 |
0e+00 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 855.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 1 MDSTLISTRPDEGTLSLSRARRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLG 80
Cdd:PRK09952 1 MDSTLISTRPDEGTLSLSRARRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 81 GVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKA 160
Cdd:PRK09952 81 GVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 161 FYSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHNQAAAKKRIP 240
Cdd:PRK09952 161 FYSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKKRIP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 241 VIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYI 320
Cdd:PRK09952 241 VIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 321 TGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIA 400
Cdd:PRK09952 321 TGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIA 400
|
410 420 430
....*....|....*....|....*....|....*...
gi 446300706 401 AALITYFAGNWHSVAIYLLAGCLISAITALLMKDNQRA 438
Cdd:PRK09952 401 AALVTYFGGSWHSVAIYLLAGCLISAMTALLMKDNQRA 438
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
21-431 |
0e+00 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 518.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 21 RRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLT 100
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 101 VWMMGIATALIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGL 180
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 181 VSLISMMTTDEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHnqAAAKKRIPVIEALLRHPGAFLKIIALRL 260
Cdd:cd17369 161 FLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKE--AGQVVRAPLVEVLRRHWRALLLAIGLRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 261 CELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQ 340
Cdd:cd17369 239 AENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 341 SIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALITYfAGNWHSVAIYLLA 420
Cdd:cd17369 319 STWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAA-TGSWWPVALYLAA 397
|
410
....*....|.
gi 446300706 421 GCLISAITALL 431
Cdd:cd17369 398 LAVISLVAALF 408
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
30-425 |
9.28e-168 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 476.76 E-value: 9.28e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 30 GAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATA 109
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 110 LIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMTT 189
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 190 DEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHNQaaAKKRIPVIEALLRHPGAFLKIIALRLCELLTMYIV 269
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKH--KKKRGPIAETLTKHRKPFLLGLGLVIATTTTFYLI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 270 TAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFWIVFFS 349
Cdd:TIGR00883 239 TTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFFFL 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446300706 350 IMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALITYFaGNWHSVAIYLLAGCLIS 425
Cdd:TIGR00883 319 VLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMT-GDWYAIGYYLAALALIG 393
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
25-436 |
8.77e-84 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 262.62 E-value: 8.77e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 25 LGSFAGAVVDWYDFLLYGITAaLVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMM 104
Cdd:cd17367 2 LGGSVGNLVEWYDWYVYAAFA-LYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 105 GIATALIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLI 184
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 185 SMMTTDEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQqhnQAAAKKRIPVIEALLRHPGAFLKIIALRLCELL 264
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAI---AESNEASAGTLRELRRHPRELLLVVGLTAGGTL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 265 TMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFW 344
Cdd:cd17367 238 AFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPY 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 345 IVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAaaliTYFAGNWHSVA--IYLLAGC 422
Cdd:cd17367 318 TAFALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVA----LWLKSIGHEWVffWYVAGLI 393
|
410
....*....|....
gi 446300706 423 LISAITALLMKDNQ 436
Cdd:cd17367 394 AISLVVYLRMPETR 407
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
18-434 |
5.59e-75 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 242.69 E-value: 5.59e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 18 SRARRAALGSFAGAVVDWYDFLLYGITAaLVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRML 97
Cdd:PRK10642 12 GKLRKAITAASLGNAMEWFDFGVYGFVA-YALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 98 MLTVWMMGIATALIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLS 177
Cdd:PRK10642 91 AITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 178 TGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFeqQQHNQAAAKK---------RIPVIEALLRH 248
Cdd:PRK10642 171 AGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAF--QQHVDKLEQGdreglqdgpKVSFKEIATKH 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 249 PGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRE--LFLNIGLLVGGLscLTIPCFAWLADRFGRRRVYITGALIG 326
Cdd:PRK10642 249 WRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDhgVLIIIAIMIGML--FVQPVMGLLSDRFGRRPFVILGSVAL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 327 TLSAFPFFMALEAQSIFWIvFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVaSVVGGGFTPFIAAALITY 406
Cdd:PRK10642 327 FVLAIPAFILINSNVIGLI-FAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNI-SVLVAGLTPTLAAWLVES 404
|
410 420
....*....|....*....|....*...
gi 446300706 407 fAGNWHSVAIYLLAGCLISAITALLMKD 434
Cdd:PRK10642 405 -TQNLMMPAYYLMVVAVIGLITGVTMKE 431
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
30-435 |
8.85e-74 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 236.10 E-value: 8.85e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 30 GAVVDWYDFLLYGITAALVfNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATA 109
Cdd:cd17366 7 GNAMEWFDFGVYGYLAVTI-GKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAASTF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 110 LIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMTT 189
Cdd:cd17366 86 CIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLLT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 190 DEQFLSWGWRIPFLFSIVLVLGALWVRNgmeesaefeqqqhnqaaakkripvieallrhpgAFLKIIALRLCELLTMYIV 269
Cdd:cd17366 166 EAQMLDWGWRIPFLIAAPLGLVGLYLRR---------------------------------PLLICIGLVLVFNVTNYML 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 270 TAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFWIVFFS 349
Cdd:cd17366 213 LSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAAIFIGL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 350 IMLANIahdmVVCVQQPM---FTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALITYfAGNWHSVAIYLLAGCLISA 426
Cdd:cd17366 293 LVLGLL----LSCYTATMastLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSA-TGNPLMPAYYLMVAAVVGL 367
|
....*....
gi 446300706 427 ITALLMKDN 435
Cdd:cd17366 368 VAVLFLTET 376
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
25-433 |
3.37e-64 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 211.85 E-value: 3.37e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 25 LGSFAGAVVDWYDFLLYGITAALVfNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMM 104
Cdd:cd17368 2 LAATSGNALEFFDFGVYGFFAVYI-GRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 105 GIATALIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLI 184
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 185 SMMTTDEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHNQAAAKkripVIEALLRHPGAFLKIIALRLCELL 264
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRRE----LFALLANNRRIILLGMLLVAGSTV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 265 TMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFW 344
Cdd:cd17368 237 TFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSFG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 345 IVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALItYFAGNWHSVAIYLLAGCLI 424
Cdd:cd17368 317 RLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLI-ELTGSPLAPAWYLMGAALL 395
|
....*....
gi 446300706 425 SAITALLMK 433
Cdd:cd17368 396 GLLATLMLR 404
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-430 |
4.79e-62 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 204.76 E-value: 4.79e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 24 ALGSFAGAVVDWYDFLLYGITAALVFnreffPQVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWM 103
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLA-----AEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 104 MGIATALIGILPSfstigwwaPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSL 183
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 184 ISMMTTDEqflsWGWRIPFLFSIVLVLGALWVRNGMeesaefeqqqhnqaaakkripvieallrhpgafLKIIALRLCEL 263
Cdd:cd17316 148 LIPLLSGD----WGWRILFLIGALPALLALLLRRRT---------------------------------LLLILLWFFIS 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 264 LTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQsiF 343
Cdd:cd17316 191 FGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGS--P 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 344 WIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALITYfaGNWHSVAIYLLAGCL 423
Cdd:cd17316 269 TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST--GGTGVPALILALLAI 346
|
....*..
gi 446300706 424 ISAITAL 430
Cdd:cd17316 347 VALIVAL 353
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
1-432 |
1.62e-56 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 192.72 E-value: 1.62e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 1 MDSTLISTRPDEGTLSLSRARRAALGSFAGAVVDWYDFLLYGItAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLG 80
Cdd:PRK10406 1 MAESTVTADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSF-CSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 81 GVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKA 160
Cdd:PRK10406 80 GWLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 161 FYSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHNQAAAKKrip 240
Cdd:PRK10406 160 FYASFQYVTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALKEAGSLK--- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 241 vieALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYI 320
Cdd:PRK10406 237 ---GLWRNRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSML 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 321 TGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIA 400
Cdd:PRK10406 314 CFGSLAALFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVA 393
|
410 420 430
....*....|....*....|....*....|..
gi 446300706 401 AALITyfAGNWHSVAIYLLAGCLISAITALLM 432
Cdd:PRK10406 394 LSLKS--IGMETAFFWYVTLMAVVAFLVSLML 423
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
22-432 |
7.80e-50 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 174.75 E-value: 7.80e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 22 RAALGSFAGAVVDWYDFLLYGITAALVfNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTV 101
Cdd:PRK15075 15 RAILRVTSGNFLEMFDFFLFGFYATAI-AKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 102 WMMGIATALIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLV 181
Cdd:PRK15075 94 SIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 182 SLISMMTTDEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHNQAAAKkripVIEALLRHPGAFLKIIALRLC 261
Cdd:PRK15075 174 YLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHRPSMRE----IFRSLAANWRIVLAGMLMVAM 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 262 ELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQS 341
Cdd:PRK15075 250 TTVSFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVLAILTAYPALSWLVAAP 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 342 IF--------WIVFFSIMLaNIAhdMVVCVqqpmfTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALITYfAGNWHS 413
Cdd:PRK15075 330 SFarmlavelWLSFLYGSY-NGA--MVVAL-----TEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHV-TGDKAA 400
|
410
....*....|....*....
gi 446300706 414 VAIYLLAGCLISAITALLM 432
Cdd:PRK15075 401 PGYWLSFAAVCGLIATLVL 419
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
26-434 |
2.28e-28 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 115.48 E-value: 2.28e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 26 GSFAGAVVDWYDFLLYGITAALVfnREFFPQVSPAMGTLAAFATFGVGFlfrplGGVIFGHFGDRLGRKRMLMLTVWMMG 105
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVLPAL--IAEFGLDEAEAGLLGTVTLAGGAI-----GGILGGILADRFGRVRVLVITILLFA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 106 IATALIGILPSFSTigwwapilLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLIS 185
Cdd:cd17371 76 VFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 186 MMTTDEqflsWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHNQAAAKKRiPVIEALLRHP--GAFLKIIALRLCEL 263
Cdd:cd17371 148 PLLPPE----IAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADR-PSLRELFSPPllRTTLLASLLATGAL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 264 LTMYIVTAFALNYSTQNMGLPRE------LFLNIGLLVGGLscltipCFAWLADRFGRRRVYITGALIGTLSAFPFFMAL 337
Cdd:cd17371 223 GGYYGITTWLPSYLTGERGLSFEgsagylVVTILGGFLGYL------AGGFLADRIGRRNNFALFALGSAISILLYFFLP 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 338 EAQSIFWIVFFSIMLANIAhdmVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFtPFIAAALITyfAGNWHS-VAI 416
Cdd:cd17371 297 LSPTLILILGFPLGFFASG---PFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALF-PFLVGFLAT--SGSLGTaIAV 370
|
410
....*....|....*...
gi 446300706 417 YLLAGCLISAITALLMKD 434
Cdd:cd17371 371 FAAVYYIAGLVLALLLPE 388
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-438 |
3.10e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 112.28 E-value: 3.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 18 SRARRAALGSFAGAVVDWYDFLLYGItAALVFNREFfpqvspAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRML 97
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSV-LAPPLAEEF------GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 98 MLTVWMMGIATALIGILPSFstigwwapILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLS 177
Cdd:COG2223 74 LIGLLLLGIGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 178 TGLVSLIsmmttdeqFLSWGWRIPFL-FSIVLVLGALWVRNGMEESAEFEQqqhnqAAAKKRIPVIEALLRHPgAFLKII 256
Cdd:COG2223 146 AFLAPLL--------IAAFGWRNAFLiLGILLLVVAVLAWLFLRDPPAGAA-----AAAKASLRDQLEALRDP-RFWLLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 257 ALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMA 336
Cdd:COG2223 212 LLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 337 LEAqsiFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASvVGGGFTPFIAAALITYFaGNWHSVAI 416
Cdd:COG2223 292 LGS---LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGG-LGGFLGPLLFGALLDAT-GSYTAAFL 366
|
410 420
....*....|....*....|..
gi 446300706 417 YLLAGCLISAITALLMKDNQRA 438
Cdd:COG2223 367 VFAVLALVALVLTLLLYRRPRR 388
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-433 |
7.57e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 99.17 E-value: 7.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 19 RARRAALGSFAGAVVDWYDFLLYGItAALVFNREFfpQVSPAMGTLAafatFGVGFLFRPLGGVIFGHFGDRLGRKRMLM 98
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSV-AAPPLQADL--GLSAAQLGLL----ASAFFLGYALGQIPAGLLADRFGRRRVLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 99 LTVWMMGIATALIGILPSFstigwwapILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLST 178
Cdd:COG2271 80 IGLLLWGLATLLFGFATSF--------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 179 GLVSLIsmmttdeqFLSWGWRIPFLFSIVLVLGALWVRngmeesaefeqqqhnqaaakkripvieallrhpgaFLKIIAL 258
Cdd:COG2271 152 PLLGWL--------LAAFGWRAAFLILGLPGLLLALLR-----------------------------------FWLLALA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 259 RLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYItgALIGTLSAFPFFMALE 338
Cdd:COG2271 189 YFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV--LAIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 339 AQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYqVASVVGGGFTPFIAAALITYFagNWHSVAIYL 418
Cdd:COG2271 267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLGGALGPLLVGYLLDAT--GYQAAFLLL 343
|
410
....*....|....*
gi 446300706 419 LAGCLISAITALLMK 433
Cdd:COG2271 344 AALALLAALLALLLL 358
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
13-326 |
3.47e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 96.03 E-value: 3.47e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 13 GTLSLSRARRAALGSFAGAVVDWYDFLLYGITAALVfnREFFPQVSPAMGTLAAfatfgVGFLFRPLGGVIFGHFGDRLG 92
Cdd:COG0477 5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSI--AADLGASSAQLGWIVS-----AYLLGRAIGLLLFGRLGDRYG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 93 RKRMLMLTVWMMGIATALIGILPSfstigwwaPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGV 172
Cdd:COG0477 78 RKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 173 GLLLSTGLVSLISMMttdeqflsWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHNQAAAKKRIPVIEALLRHPGAF 252
Cdd:COG0477 150 GLALGPLLGGLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLL 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446300706 253 LKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIG 326
Cdd:COG0477 222 LLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-392 |
3.03e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 94.27 E-value: 3.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 14 TLSLSRARRAALGSFAGAVVDWYDFLLYGITAALVFNREffpQVSPAMGTLAAFATFgvgfLFRPLGGVIFGHFGDRLGR 93
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL---GASPAQAGLVVTAYL----LGAALGAPLAGRLADRFGR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 94 KRMLMLTVWMMGIATALIGILPSFstigwwapILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVG 173
Cdd:COG2814 75 RRVLLLGLLLFALGSLLCALAPSL--------WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 174 LLLSTGLVSLISMmttdeqflSWGWRIPFLFSIVL-VLGALWVRNGMEESAEFEQQQHNQAaakkripvIEALLRHPgAF 252
Cdd:COG2814 147 PALGPLLGGLLAD--------LFGWRWVFLVNAVLaLLALLLLLRLLPESRPAARARLRGS--------LRELLRRP-RL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 253 LKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFP 332
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 333 FFMAleaqSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVG 392
Cdd:COG2814 290 LALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
23-403 |
2.20e-20 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 93.11 E-value: 2.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 23 AALGSFagavVDWYDFLLYG-ITAALVFNREFFPQVSPAMGTLAAF---ATFGVGFLFRPLGGVIFGHFGDRLGRKRMLM 98
Cdd:pfam00083 5 AALGGF----LFGYDTGVIGaFLTLIDFFKNFGLSKSVSSLAALSVlsgLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 99 ltvwmMGIATALIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLST 178
Cdd:pfam00083 81 -----IANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 179 GLVsLISMMTTDeqflSWGWRIPF----LFSIVLVLGALWVRN---------GMEESAEFEQQQHNQAAAKKRIPVIEAL 245
Cdd:pfam00083 156 IFG-LGLNKTSN----SDGWRIPLglqlVPALLLIIGLLFLPEsprwlvekgRLEEAREVLAKLRGVPDVDRELDEIKDS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 246 LRHPGAFLKIIALRLCEL------LTMYIVTAFALNYSTQN--MGLPRELFLNIGL--------LVGGLSCLTIPCFAWL 309
Cdd:pfam00083 231 LEAGQEAEKASWKELFSTktrrqrLLIGVMLQIFQQLTGINaiFYYSTTIFENLGLsdsflvtiIVGVVNFVFTFIAIFL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 310 ADRFGRRRVYITGALIGTLSAF----PFFMALEAQSIFWIVF-FSIMLANIAHDMVV-CVQQPMFTEMFGASYRYSGAGV 383
Cdd:pfam00083 311 VDRFGRRPLLLLGAAGMAICFVilgiVALLGVSKSDWAGIVAiVFIALFIAFFAMGWgPVPWVIVSELFPLSVRSKAMAL 390
|
410 420
....*....|....*....|...
gi 446300706 384 GYQ---VASVVGGGFTPFIAAAL 403
Cdd:pfam00083 391 ATAanwLANFLIGFLFPIITDAI 413
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
10-432 |
2.57e-19 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 89.58 E-value: 2.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 10 PDEGTLSLSRARRAALGSFAGAVVdwydFLLYGITAALVFNREFFpqVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGD 89
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLA----FGLLSAYLLYFYTDVLG--LSAALVGLILLVARLWDAITDPLIGALSDRTRT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 90 RLGRKRMLML-TVWMMGIATALIGILPSFSTIG--WWAPILLVTLRAIQGFAVGGEWggaALLSVESAPKNKKAFYSSGV 166
Cdd:COG2211 76 RWGRRRPWILiGAIPLALSFVLLFTAPDLSPTGklIYALVTYLLLGLAYTLVNIPYS---ALGAELTPDYEERTRLSSWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 167 QVGYGVGLLLSTGLVSLISMMTTDEQflSWGWRIPFL-FSIVLVLGALWVRNGMEESAefeqqqhnqAAAKKRIPVIEAL 245
Cdd:COG2211 153 FAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALiFAVLGLLAFLLTFFGTKERP---------VPEEEKVSLKESL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 246 --LRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGA 323
Cdd:COG2211 222 kaLLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 324 LIGTLSAFPFFMALEAQsiFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSG---AGV---GYQVASVVGGGFTP 397
Cdd:COG2211 302 LLAALGLLLLFFLGPGN--LWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGrrrEGLyfgIFTFAIKLGQALAG 379
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 446300706 398 FIAAALITYF----------AGNWHSVAIYLLAGCLISAITALLM 432
Cdd:COG2211 380 ALAGLLLALFgyvagaaqspSALTGIRLLFFLLPAVLLLLAALLL 424
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
21-407 |
3.32e-18 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 86.14 E-value: 3.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 21 RRAALGSFAGAVVDWYDFLLygitaalVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLT 100
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFML-------IFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 101 VWMMGIATALIGILPSFstigwwapILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGL 180
Cdd:PRK12307 90 IVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 181 VSLISMmttdeqflSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQ------HNQAAAKKRIPVIEALLRHPGAFLK 254
Cdd:PRK12307 162 MPSFAE--------AYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKlsgkgkHSQSAWSVFSLSMKGLFNRAQFPLT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 255 IIALRLCELL--TMYIVTAFALNYSTQNmGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFP 332
Cdd:PRK12307 234 LCVFIVLFSIfgANWPIFGLLPTYLAGE-GFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFP 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446300706 333 -FFMALEAQSIFWIVFFSIMLANIAHDMVVcvqqPMFT-EMFGASYRYSGAGVGYQVASvVGGGFTPFIAAALITYF 407
Cdd:PRK12307 313 lFRIPQDNYLLLGACLFGLMATNVGVGGLV----PKFLyDYFPLEVRGLGTGLIYNLAA-TSGTFNSMAATWLGITM 384
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
16-403 |
2.83e-17 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 83.98 E-value: 2.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 16 SLSRA-RRAALGSFAGAVVDWYDFLLygITAALV-FNREFfpqvspAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGR 93
Cdd:PRK03893 13 HLNRAqWKAFSAAWLGYLLDGFDFVL--ITLVLTeVQGEF------GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 94 KRMLMLTVWMMGIATALIGILPSFSTigwwapilLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVG 173
Cdd:PRK03893 85 RLAMVISIVLFSVGTLACGFAPGYWT--------LFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 174 LLLSTGLVSLIsmmttdeqFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHNQAA----------AKKRIP--- 240
Cdd:PRK03893 157 AVVAAQVYSLV--------VPVWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKAPvrtmvdilyrGEHRIInil 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 241 ----------VIEALLRHPGAFLKIIAL----------------RLCELLTMYIVTAFALNYS--TQNMgLPRELFLNIG 292
Cdd:PRK03893 229 ltlaaaaalwFCFAGNLQNAAIVAVLGLlcaaifisfmvqssgkRWPTGVMLMVVVLFAFLYSwpIQAL-LPTYLKTDLG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 293 LLVGGLS-CLTIPCF---------AWLADRFGRRRVYITGALIGTLSAFPFFmALEAQSIFWI---VFFSIMLANIAHDM 359
Cdd:PRK03893 308 YDPHTVAnVLFFSGFgaavgccvgGFLGDWLGTRKAYVCSLLISQLLIIPVF-AIGGANVWVLgllLFFQQMLGQGISGL 386
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 446300706 360 VvcvqqPMF-TEMFGASYRYSGAGVGYQVASvVGGGFTPFIAAAL 403
Cdd:PRK03893 387 L-----PKLiGGYFDTEQRAAGLGFTYNVGA-LGGALAPILGALI 425
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
70-397 |
4.50e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 72.84 E-value: 4.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 70 FGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFStigwwapiLLVTLRAIQGFAVGGEWGGAALL 149
Cdd:pfam07690 38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW--------LLLVLRVLQGLGAGALFPAALAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 150 SVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMmttdeqflSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQ 229
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS--------LFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 230 HNQAAAKKRIPVIEALLRHPgaFLKIIALRLCELLTMYIVTAFALNYSTQnMGLPRELFLNIGLLVGGLSCLTIPCFAWL 309
Cdd:pfam07690 182 PAEEARLSLIVAWKALLRDP--VLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 310 ADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFWIVFFSIMLAnIAHDMVVCVQQPMFTEMFGASYRYSGAGVgYQVAS 389
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLG-FGFGLVFPALNALVSDLAPKEERGTASGL-YNTAG 336
|
....*...
gi 446300706 390 VVGGGFTP 397
Cdd:pfam07690 337 SLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
59-430 |
5.60e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.97 E-value: 5.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 59 PAMGTLAAFATFGVGflfrpLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFstigwwapILLVTLRAIQGFA 138
Cdd:cd17324 34 AQAGLLVSAYALGYA-----LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF--------ALLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 139 VGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMttdeqflsWGWRIPFL-FSIVLVLGALWVRN 217
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQL--------LGWRAAFLaIAVLALLAALLLWR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 218 GMeesaefEQQQHNQAAAKKRIPVIEALLRHPGAFLkIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGG 297
Cdd:cd17324 173 LL------PSLPPKKPGSLGLLSSLLLLLRNPRLRL-AYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 298 LSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMAleaqSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASyr 377
Cdd:cd17324 246 AGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG----PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-- 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446300706 378 YSGAGVGYQVASVVGGGFTPFIAAALITyfAGNWHSVAIYLLAGCLISAITAL 430
Cdd:cd17324 320 RGLASSLYLAAYNLGGALGAALGGLVLD--HGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
70-433 |
6.87e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.61 E-value: 6.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 70 FGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFstigwwapILLVTLRAIQGFAVGGEWGGAALL 149
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY--------WQLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 150 SVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMmttdeqflSWGWRIPFLFSIVLVLGALWVRNGMEEsaEFEQQQ 229
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD--------ALGYRAPFLVCAALALLALVLALLLLP--EPRPPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 230 HNQAAAKKRIPVIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWL 309
Cdd:cd17325 179 NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 310 ADRFGRRRVYITGALIGTLSAFPFFMAleaqSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVgYQVAS 389
Cdd:cd17325 259 SDRIGRKPLILIGLLLSAVALLLLPLA----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL-FNTAF 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446300706 390 VVGGGFTPFIAAALITYFAGNWhsvAIYLLAG-CLISAITALLMK 433
Cdd:cd17325 334 SLGMVLGPLLGGFLYDAFGFAT---PFLAAAAlLLLAAVLFLLLR 375
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
22-404 |
2.85e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 67.77 E-value: 2.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 22 RAALGSFAGAVVDWYDFLLYGITAALVfNREFfpQVSPA-MGTLAAFATFGVGFlfrplGGVIFGHFGDRLGRKRMLMLT 100
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAI-SAEW--GLDPVqLGFLFSAGLIGMAF-----GALFFGPLADRIGRRRVLLWS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 101 VWMMGIATALIGILPSFstigwwapILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAF----YSSGVQVGYGVGLLL 176
Cdd:TIGR00895 89 ILLFSVFTLLCALATNV--------TQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTavglMFCGYPIGAAVGGFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 177 STGLVSLIsmmttdeqflswGWRIPFLF-SIVLVLGALWVRNGMEESAEFEQQQHNQAAAKKRIPVIEALLRHPGAFLKI 255
Cdd:TIGR00895 161 AGWLIPVF------------GWRSLFYVgGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 256 ----------------------IALRLCELLTMYIVTAFALN------YSTQNMGLPRELFLNIGLLVGGLSCLTIpcFA 307
Cdd:TIGR00895 229 qkstqgtkrsvfkalfqgktarITVLLWLLYFMLLVGVYFLTnwlpklMVELGFSLSLAATGGALFNFGGVIGSII--FG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 308 WLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQqpmfTEMFGASYRYSGAGVGYQV 387
Cdd:TIGR00895 307 WLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALM----ALFYPTAIRATGVGWAIGI 382
|
410
....*....|....*..
gi 446300706 388 ASvVGGGFTPFIAAALI 404
Cdd:TIGR00895 383 GR-LGAIIGPILAGYLL 398
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
66-432 |
7.09e-12 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 66.06 E-value: 7.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 66 AFATFGVGFLFrplGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFStigwwapiLLVTLRAIQGFAVGGEWGG 145
Cdd:cd17317 30 VQTIFFLGVLI---GSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 146 AALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISmmttDEQFLSWGWRIPFLFSIVLvlgaLWVrngmeesaef 225
Cdd:cd17317 99 GFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIR----DWRWLQLAISLPGLLFLLL----LWW---------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 226 eqqqhnqaaakkrIPVieallrhpgaflKIIALRLCELLTMYIVTAFALNYStqnmGLPRELFLNIGL--LVGGLSCLTI 303
Cdd:cd17317 161 -------------LPR------------RTIIVGLIWFVTSLVYYGLSLNSS----NLGGNLYLNFFLsgLVEIPAYFLA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 304 PcfaWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFWIVFFsiMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGV 383
Cdd:cd17317 212 L---LLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLA--LVGKFAISAAFSVIYLYTAELYPTVVRNTGVGL 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446300706 384 GYQVASvVGGGFTPFiaaalITYFAGNWHSVAIYLLAGC-LISAITALLM 432
Cdd:cd17317 287 CSTVAR-VGAILAPF-----IVLLGKIGPLLPLIIFGVLaLLGGLLTLLL 330
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
70-432 |
9.24e-12 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 66.58 E-value: 9.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 70 FGVGFLfrpLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFStigwwapiLLVTLRAIQGFAVGGEWGGAALL 149
Cdd:TIGR00898 136 FFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYT--------VFLVFRLLVGMGIGGIWVQAVVL 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 150 SVESAPKNKKAFYSSGVQVGYGVGLLlstgLVSLISMMTTDEQFLSWGWRIPFLFSIVLVlgaLWVrngmEESAEFEQQQ 229
Cdd:TIGR00898 205 NTEFLPKKQRAIVGTLIQVFFSLGLV----LLPLVAYFIPDWRWLQLAVSLPTFLFFLLS---WFV----PESPRWLISQ 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 230 HNQAAA------------------------------KKRIPVIEALLRHPgaflkiiALRLCELLTMYIVTAFALNYSTQ 279
Cdd:TIGR00898 274 GRIEEAlkilqriakingkklpaevlslslekdlssSKKQYSFLDLFRTP-------NLRKTTLCLMMLWFTTAFSYYGL 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 280 NMGLPrELFLNI--GLLVGGLSCLTIPCFAWLA-DRFGRRRVYITGALIGTLSAfpFFMALEAQSIFWI----VFFSIML 352
Cdd:TIGR00898 347 VLDLG-NLGGNIylDLFISGLVELPAKLITLLLiDRLGRRYTMAASLLLAGVAL--LLLLFVPVDLYFLrtalAVLGKFG 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 353 ANIAHDMVVcvqqpMFT-EMFGASYRYSGAGVGyQVASVVGGGFTPFIAaalitYFAGNWHSVAIYLLAGC-LISAITAL 430
Cdd:TIGR00898 424 ITSAFQMVY-----LYTaELYPTVVRNLGVGVC-STMARVGSIISPFLV-----YLGEKWLFLPLVLFGGLaLLAGILTL 492
|
..
gi 446300706 431 LM 432
Cdd:TIGR00898 493 FL 494
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
27-408 |
1.06e-10 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 63.51 E-value: 1.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 27 SFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMltvwMMGI 106
Cdd:TIGR00879 34 AIGGLMFGYDTGVIGGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLL----IIAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 107 ATALIGILPSFSTIGWWAPILLVTlRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISM 186
Cdd:TIGR00879 110 LFVIGAILMGLAAFALSVEMLIVG-RVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 187 MTTDEQF-----LSWGWRIPFLFSIVLVLGALW--VRNGMEESAEFEQQQHNQAAAKKRI-----PVIEALLRHPGAFLK 254
Cdd:TIGR00879 189 LNNTLGWriplgLQLIPAGLLFLGLFFLPESPRwlVGKGRVEEARKSLARLRGTSGEDKElldelELIDIKRSIEKRSVQ 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 255 IIALRLCEL-------LTMYIVTAFA---------LNYST---QNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGR 315
Cdd:TIGR00879 269 PSWGSLFSStrrirrrLFLGVVLQWFqqftginaiMYYSPtifENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGR 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 316 RRVYITGALIGTLS----AFPFFMAL--EAQSIFWIVFFSIMLANIAHDM-VVCVQQPMFTEMFGASYRYSG---AGVGY 385
Cdd:TIGR00879 349 RPLLLIGAAGMAIClfvlGILGASFVtgSSKSSGNVAIVFILLFIAFFAMgWGPVPWVIVSEIFPLSLRPKGisiAVAAN 428
|
410 420
....*....|....*....|...
gi 446300706 386 QVASVVGGGFTPFIAAALITYFA 408
Cdd:TIGR00879 429 WLANFIVGFLFPTMLESIGVGGV 451
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
70-423 |
1.12e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 62.83 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 70 FGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTigwwapilLVTLRAIQGFAVGGEWGGAALL 149
Cdd:cd06174 37 FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWL--------LLLGRFLLGLGSGLIDPAVLAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 150 SVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMmttdeqFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQ 229
Cdd:cd06174 109 IADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS------SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 230 HNQAAAKKRIPVIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWL 309
Cdd:cd06174 183 KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 310 ADRFGRRRV--YITGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASyrYSGAGVGYQV 387
Cdd:cd06174 263 SDRLIGRKPllLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTA--FGLLNTFGFL 340
|
330 340 350
....*....|....*....|....*....|....*.
gi 446300706 388 ASVVGGGFTPFIAAALITYFAGNWHSVAIYLLAGCL 423
Cdd:cd06174 341 GGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
57-433 |
1.72e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 59.12 E-value: 1.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 57 VSPAMGTLAAFATFGVGFLFRPLGGVIfghfGDRLGRKRMLMLTVWMMGIATALIGILPSFSTigwwapilLVTLRAIQG 136
Cdd:cd17474 31 ASPAQVGLLITAFTLPAAVLMPVAGVL----ADRFGRKKVLLPGLLLFGIGGLLCGLSDSFAL--------LLAGRALQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 137 FAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMmttdeqflsWGWRIPFLFSIVLVLGALWVR 216
Cdd:cd17474 99 IGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA---------ISWRYPFFLLAALIPVAFLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 217 NGMEEsaefEQQQHNQAAAKKRIPVIEALLRHPGAFLKIIALrlceLLTMYIVTAFaLNYSTQNMGLPRELF-LNIGLLV 295
Cdd:cd17474 170 LFLLP----EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSA----FLYFFLYFAF-LTYLPFLLELLYGISpIIIGLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 296 GGLS---CLTIPCFA-WLADRFGRRRVYITGALIGTLSafpfFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEM 371
Cdd:cd17474 241 AGWSvllALGSLFVGrLLKKRFGARRILVIGLLLYALS----LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTEL 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446300706 372 FGASYRYSGAGVgYQVASVVGGGFTPFIAAALitYFAGNWHSVaiYLLAGCLISAITALLMK 433
Cdd:cd17474 317 APEEERGTASSL-YNFVRFLGQAVGPLLFGLL--LEIFGLSAP--FLVGAAIALAAAVLLAL 373
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
27-367 |
2.72e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 58.34 E-value: 2.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 27 SFAGAVVDWYDFLLYGITAALVFNREFfpqvSPAMGTLAAFATFGVGFLFRPLggviFGHFGDRLGRKRMLMLTVWMMGI 106
Cdd:cd17478 2 SLGHFLNDFYQGFLPALLPLLIAKLGL----SYAQAGLLVSVFSITSSLLQPL----FGYLADRKPRRYLLPLGPLLTGL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 107 ATALIGILPSFStigwwapiLLVTLRAIQGFAVGG-EWGGAALLSVESAPKNKKA--FYSSGVQVGYGVGLLLSTGLVSL 183
Cdd:cd17478 74 GLSLLGFAPNYW--------LLLLLVALAGIGSAAfHPEGARLASQAAGGRRGLAmsIFSVGGNLGFALGPLIAAALVAL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 184 ISMmttdeqfLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHNQAAAKKRIPVIEALLrhpgAFLKIIALRLCEL 263
Cdd:cd17478 146 FGG-------LGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLL----IIVFLRSWVLSSL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 264 LTMYIVTAFALNYSTQNMGlpreLFLNIGLLVGGLSCLTipcFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIF 343
Cdd:cd17478 215 TTFLPFYLVQRGYSLVFAG----LLLSLFLFAGAIGTLI---GGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYI 287
|
330 340
....*....|....*....|....
gi 446300706 344 WIVFFSIMLANIAHDMVVCVQQPM 367
Cdd:cd17478 288 LLVLAGFLLFASFPVTVVLAQELL 311
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
70-432 |
8.01e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 57.28 E-value: 8.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 70 FGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTigwwapilLVTLRAIQGFAVGGEWGGAALL 149
Cdd:PRK11551 56 FSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIAL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 150 SVESAPKNKKafySSGVQVGYgVGLLLSTGLVSLISMMTTDEQflswGWRIPFLFS-----IVLVLGALWvrngMEESAE 224
Cdd:PRK11551 128 TSEAVGPRLR---GTAVSLMY-CGVPFGGALASVIGVLAAGDA----AWRHIFYVGgvgplLLVPLLMRW----LPESRA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 225 FEQQqhnQAAAKKRIPVIEALLRhPGAFLKIIALRLCELLTMyIVTAFALNYSTQNM---GLPR------ELFLNIGllv 295
Cdd:PRK11551 196 FAQA---AGAGKQRAPVLRALFG-EGRATATLLLWISYFFTL-IVLYFLLNWLPSLLvgqGLSRsqaglvQIAFNIG--- 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 296 GGLSCLTIpcfAWLADRFGRRRVyITGALIGTLSAfpfFMALEAQSifwiVFFSIMLANIAHDMVVCVQQPMFTEMFGAS 375
Cdd:PRK11551 268 GALGSLLI---GALMDRLRPRRV-VLLIYAGILAS---LAALAAAP----SFAGMLLAGFAAGLFVVGGQSVLYALAPLF 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446300706 376 YRYS--GAGVGYQVA-----SVVGggftPFIAAALITyfAGnwHSVAIYLLA---GCLISAITALLM 432
Cdd:PRK11551 337 YPTQvrGTGVGAAVAvgrlgSMAG----PLLAGQLLA--LG--RSTVGVIGAsipVILVAALAALLL 395
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
58-433 |
1.30e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.39 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 58 SPAMGTLAAFATFGVGFLFRPLGGVIfghfGDRLGRKRMLMLTVWMMGIATALIGILPSFSTIGWWAPILLVTLRAIQGF 137
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVL----ADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 138 AVGGEWGGA--ALLSVESAPKNkKAFYSSGVQVGYGVGLLLSTGLVSLismmttdeqflsWGWRIPFLFSIVLVLGALWV 215
Cdd:cd06173 108 FFGPARQALlpELVPKEQLVRA-NALNSLATQLARIIGPALGGLLVAL------------LGPGGAFAINALSFLLSALL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 216 RNGMEESAEFEQQQHNQAAAKKRIPVIEALLRHPGAFLKIIALRLCELLTMYIVTAFALnYSTQNMGLPRELF------L 289
Cdd:cd06173 175 LLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPL-LAKEVLGGGAAGYglllaaF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 290 NIGLLVGGLSCltipcfAWLADRFGRRRVYITGALIGTLSAFPFFMAleaqSIFWIVFFSIMLANIAHDMVVCVQQPMFT 369
Cdd:cd06173 254 GVGALLGALLL------GRLSKRRRRGRLLLIGALLLGLALLVLGLS----PSLWLLLAALFLLGLAGGLFNVPLNTLLQ 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446300706 370 EMFGASYRysgaGVGYQVASVVGGGFTPfIAAALITYFAGNWHSVAIYLLAGCLISAITALLMK 433
Cdd:cd06173 324 LRVPDELR----GRVFSVYNALNSGAMP-LGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
68-348 |
8.07e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 50.63 E-value: 8.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 68 ATFGVGFLfrpLGGVIFGHFGDRLGRKRMLMLtvwMMGIATALIGILPSFSTIGWWAPillvtLRAIQGFAVGGEWGGAA 147
Cdd:cd17477 38 SAYYLGIL---LGSPLVPRLIRRVGHIRAFAA---GAAITAVSVLLLALTDSPWVWFL-----LRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 148 LLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMttdeqflswGWRIPFLFSIVLVLGALWVRNGMEESAEFEQ 227
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA---------GALPFLIAAVLLLLALVPLLLTRRAAPEIEE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 228 QQHnqaaakkrIPVIEALLRHPGAFLKIIALRLCE--LLTMYIVTAFALNYSTQNMGLPrelflnIGLLVGGLSCLTIPc 305
Cdd:cd17477 178 AES--------ISLRRLLRIAPLALLGAFVAGFLEgaFYSLLPLYGLRLGLSVAQAALL------LAAFVLGGLLLQWP- 242
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 446300706 306 FAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFWIVFF 348
Cdd:cd17477 243 LGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLF 285
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
56-424 |
1.19e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 50.24 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 56 QVSPAMGTLAAFAtFGVGFLfrpLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFstigwwapILLVTLRAIQ 135
Cdd:COG0738 39 GLSDAQAGLLLFA-FFLGYL---LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 136 GFAVGGEWGGAALLSVESAPKNKKAFYSSGvQVGYGVGLLLSTGLVSLISMMTtdeqfLSWGWRIPFLFS--IVLVLGAL 213
Cdd:COG0738 107 GLGLGLLDVAANPYVAALGPETAASRLNLL-HAFFSLGALLGPLLGGLLILLG-----LSLSWHLPYLILavLLLLLALL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 214 WVRNGMEESAEFEQQQHNQAAAKKRipvieaLLRHPGAFLKIIALrLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGL 293
Cdd:COG0738 181 FLRSKLPEIEEEEEEAAGSAASLKS------LLKNPRLLLGGLAI-FLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 294 LVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMAleaqSIFWIVFFSIMLANIAHDMVVCVqqpMFTEMFG 373
Cdd:COG0738 254 LFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLA----PGPWLALIGLALVGLGLSLMFPT---IFSLALD 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446300706 374 ASYRYSGAGVGYQ-VASVVGGGFTPFIAAALITYFAGNWhsvAIYLLAGCLI 424
Cdd:COG0738 327 GLGKRTAAAVSAVlIMGIVGGAIGPPLIGFLADAFGLRA---AFLVPLVCYL 375
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
167-370 |
1.29e-06 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 50.30 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 167 QVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHNQAAAKKripVIEALL 246
Cdd:cd17332 142 MFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLK---SLKALL 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 247 RHPgAFLKIIALRLCELLTMYIVTAFALNYSTQNMGlPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIG 326
Cdd:cd17332 219 KNR-PFLILLLAYLLYFLAFNIVNTVLVYYFKYVLG-GRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLA 296
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 446300706 327 TLsAFPFFMALEAQSIFWIVFFSImLANIAHDMVVCVQQPMFTE 370
Cdd:cd17332 297 IL-GLLLLFFLPPGNLVLILVLAV-LAGIGYGGANLLPWAMLAD 338
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
68-184 |
1.86e-06 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 49.66 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 68 ATFGVGFLFrplGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFstigwwapILLVTLRAIQGFAVGGEWGGAA 147
Cdd:cd17379 40 SSLNLGFLI---GSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGGWMTGY 108
|
90 100 110
....*....|....*....|....*....|....*..
gi 446300706 148 LLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLI 184
Cdd:cd17379 109 VLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFI 145
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
68-225 |
1.93e-06 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 50.11 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 68 ATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTIGWWApiLLVTLRAIQGFAVGGEWGGAA 147
Cdd:TIGR00887 60 AVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 148 LLSVESAPKNKKAFYSSGVQVGYGVGlLLSTGLVSLISMMTTDEQF----------------LSWGWRIPFLFSIVLVLG 211
Cdd:TIGR00887 138 IITSEFATKKWRGAMMAAVFAMQGFG-ILAGAIVALIVLAGFKHSLeaaadeasctgscvpaVDYMWRILIGFGAVPALL 216
|
170
....*....|....
gi 446300706 212 ALWVRNGMEESAEF 225
Cdd:TIGR00887 217 ALYFRLTIPETPRY 230
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
80-216 |
4.46e-06 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 48.43 E-value: 4.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 80 GGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGIlpSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKK 159
Cdd:cd17364 55 GQLFFGFLGDRFGRKRVYGVELIIMIIGTILSAL--SPGSTPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRR 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446300706 160 AFYSSGVQVGYGVGLLLStGLVSLISMMTTDEQF-------LSWGWRIPFLFSIVLVLGALWVR 216
Cdd:cd17364 133 GALIAAVFAMQGFGILAG-AIVTLILSAIFEHPLpagtyhhADLVWRIVLGLGAIPALSVLYFR 195
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
31-210 |
6.55e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 47.97 E-value: 6.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 31 AVVDWYDFLLYGITAALVFnREFfpQVSPA-MGTLAAFATFGVGflfrpLGGVIFGHFGDRLGRKRMLMLTVWMMGIATA 109
Cdd:cd17365 8 IVLDGFDLAVMGFVAPALA-QDW--GLSPAqLGPVGSAALFGMA-----IGALLAGPLADRFGRKRVLLVSVALFGLFTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 110 LIGILPSFSTigwwapilLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLsTGLVSLISMMTt 189
Cdd:cd17365 80 LTAFAQSVLQ--------LALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAAL-GGFLAAALIPA- 149
|
170 180
....*....|....*....|.
gi 446300706 190 deqflsWGWRIPFLFSIVLVL 210
Cdd:cd17365 150 ------FGWRSVFLLGGVPPL 164
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
69-332 |
6.98e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.03 E-value: 6.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 69 TFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFstigWWapilLVTLRAIQGFaVGGEWGGAAL 148
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNV----WQ----LLILRLLQGV-FSGYVPNATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 149 LSVESAPKNKKafyssgvqvGYGVGlLLSTGLVSLISMMTTDEQFL--SWGWRIPFLF-SIVLVLGALWVRNGMEESAEF 225
Cdd:cd17391 112 LIASQTPKEKS---------GWALG-TLSTGVVAGTLIGPLLGGFLadLFGIRNVFFItGGLLFLAFLLTLFFVKEDFKP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 226 EQqqhnqaaAKKRIPVIEAL--LRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVG--GLSCL 301
Cdd:cd17391 182 VE-------KKKMVSTKEVWnsVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSatGVSSL 254
|
250 260 270
....*....|....*....|....*....|..
gi 446300706 302 -TIPCFAWLADRFGRRRVYITGALIGTLSAFP 332
Cdd:cd17391 255 lSAPRLGKLGDRIGHHRILLGALLASALLYIP 286
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
56-433 |
8.81e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 47.57 E-value: 8.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 56 QVSPAMGTLAAFATFGVGFLFRPlggvIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTigwwapilLVTLRAIQ 135
Cdd:cd17504 27 GTSAAAVSWVLTAYLLVGAVSTP----ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPV--------LIAGRALQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 136 GFAVGGEWGGAALLSVESAPKNKK---AFYSSGVQVGYGVGLLLSTGLVslismmttdeQFLSWGWRIPFLFSIVLVLGA 212
Cdd:cd17504 95 GIGGAVFPLAFALVREEFPPERVPvaqGILSATFGIGAGIGLPLGGWIV----------QHLGWRWIFWTAAPVAVLLAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 213 LwvrngmeesaefeqqqhnqaaakkrIPVIE-ALLRHPGaflkiIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNI 291
Cdd:cd17504 165 L-------------------------VPLIDlRLLRRRN-----VLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 292 GLLVGGLSCLTI--------PCFAWLADRFGRRRVYITGALIGTLSAfpFFMALEAQSIFWIVF--------FSIMLANI 355
Cdd:cd17504 215 GITEAGLLLLPGalvmliagPLAGRLIARVGPRRVLLIGLVISAVGL--LLLALLHSSLWALVVallligigLGLAFASL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 356 AHDMVVCV--QQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALITYFAGnWHSVAIYLLAGCLISAITALLMK 433
Cdd:cd17504 293 PNIVVESVppDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGVPTEGA-YVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
27-331 |
1.62e-05 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 46.86 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 27 SFAGAVVDWYDFLLYGITAALVFNREF-----FPQVSPA-MGTLAAFATFGVGFlfrplGGVIFGHFGDRLGRKRMLmlt 100
Cdd:cd17356 7 SLGGFLFGYDTGSISGILNMKSFQKYFadntgTYYPSSSrQGLIVSIVNLGSFF-----GALISSFLSDRIGRKKSI--- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 101 vwMMGIATALIGILPSFSTIGWWAPILLVtlRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLllstgL 180
Cdd:cd17356 79 --QIGCVIYIIGAIIQVAAIGKWYQLIVG--RIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGI-----L 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 181 VSLISMMTTDEQFLSWGWRIP----FLFSIVLVLGALWVrngmEESaefeqqqhnqaaakkripvieallrhPGAFLKII 256
Cdd:cd17356 150 VAYCINYGTHKLDGSAQWRIPlglqIVWGLLLLIGMFFL----PES--------------------------PRWLYRTI 199
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446300706 257 ALRLCELLTMYIVTAFALNYST---QNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAF 331
Cdd:cd17356 200 LGIMLQLFQQLTGINYFFYYGTtifQSTGLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIGAAGMSICLF 277
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
79-222 |
1.91e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 46.41 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 79 LGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTigwwapilLVTLRAIQGFAVGGEWGGAALLSVESAPKNK 158
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446300706 159 KAFYSSGVQVGYGVGLLLSTGLVSLISMMttdeqfLSWGWRIPFLFSIVLVLGALWVRNGMEES 222
Cdd:cd17315 121 RGALGTLNQLMITFGILLAYLLGLALSLS------PPGWWRLMFALAAVPALLQLLLMFFLPES 178
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
56-407 |
2.53e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 46.15 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 56 QVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLtvwmMGIATALIGILPSFSTIGW-------WAPILL 128
Cdd:pfam13347 29 GLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLL----LSAIILAVSFILLFTPPELgraplfiWLLATY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 129 VTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGV-GLLLSTGLVSLISMMTTDEQflswGWRIPFLFSIV 207
Cdd:pfam13347 105 ILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLlAAALAFPLVLILGGTGLERK----GYRIFALIGAV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 208 LVLGALW-VRNGMEESAEFEQQQHNQAAAKKRI-PVIEALLRHPgAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPR 285
Cdd:pfam13347 181 LMLLGVIiTAAGTKERVSMRSKEDTGQKEAGSLlDMLKEVFRNR-AFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 286 ElFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIgTLSAFPFFMALEAQSIfWIVFFSIMLANIAHDMVVCVQQ 365
Cdd:pfam13347 260 A-ASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALI-TIAGFALALLLGPNNT-LLFLVLYIIIGFGYGSSFFLPW 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446300706 366 PMFTEMFGASYRYSG---AGVGYQVASVV---GGGFTPFIAAALITYF 407
Cdd:pfam13347 337 SMLADVVDYGELRTGkrrEGTFFAMWSFIsklATGVGLGVSGLLLSAF 384
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
85-353 |
3.32e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 45.64 E-value: 3.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 85 GHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTigwwapilLVTLRAIQGFAVGGEWGGAALLSVESAPKNKK----A 160
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRgaamG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 161 FYSSGVQVGYGVGLLLSTGLVSlismmttdeqflSWGWRIPFLFSIVLVLGALWVrngmeesaefeqqqhnqaaakkrIP 240
Cdd:cd17503 124 LVGLVILLAPAIGPTLGGWLTD------------NLSWRWIFYINLPIGILALLL-----------------------AP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 241 VIE-ALLRHPGAFLKIIALRLCELLTMYIVTAFALnYSTQNMGLPRelfLNIGLLV---GGLSCLTIPCFAWLADRFGRR 316
Cdd:cd17503 169 LLDlRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPL-YLQNVLGYSA---FESGLVLapgGLASAILSPLVGRLLDKFGPR 244
|
250 260 270
....*....|....*....|....*....|....*..
gi 446300706 317 RVYITGALIGTLSAFPFFMALEAQSIFWIVFFSIMLA 353
Cdd:cd17503 245 LLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRG 281
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
57-432 |
7.26e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 7.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 57 VSPAMGTLAAFATFGVGF----------LFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFstigwwapI 126
Cdd:cd17473 18 IAPALPAIAQHFVPNSELlvpllltlpaLFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL--------Y 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 127 LLVTLRAIQGFAVGGEWGGA-ALLSV--ESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLIsmmttdeqflswGWRIPF- 202
Cdd:cd17473 90 ALLASRALLGIGVAGIMTLAtALIGDyfEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI------------GWRAPFl 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 203 --LFSIVLVLGALWVRNGMEESAEFEQQQHNQAAAKKRIPVIeallrhpgafLKIIALRLCELLTMY-IVTAFALNYSTQ 279
Cdd:cd17473 158 vyLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRV----------LPIYFLAFLAMLLFYvIPIQLPFLLQER 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 280 NMGLPRE--LFLNIGLLVGGLSCLtipCFAWLADRFGRRRVYITGALIGTLSafpfFMALEAQSIFWIVFFSIMLANIAH 357
Cdd:cd17473 228 GGGSAALigLALAIASLAGAIGAL---LFGRLKRRLGKRRLLAIGFALMALG----FLLLALASGLWVVLLGAILAGLGF 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446300706 358 DMVVCVQqpMFTEMFGASYRYSGAGVGYQVASVVGGGF-TPFIAAALITYFAGnwHSVAIYLLAG-CLISAITALLM 432
Cdd:cd17473 301 GLLLPTL--NSWAMSLVPPELRGRAMGIVTSAFFLGQFlSPLVLGPLVNLTGG--LSGAFLILGVlALVLAIVLLLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
255-434 |
7.67e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.72 E-value: 7.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 255 IIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALigtLSAFPFF 334
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLL---LFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 335 MALEAQSIFWIVFFSIMLAnIAHDMVVCVQQPMFTEMFGASYRYSGAGVgYQVASVVGGGFTPFIAAALITYFagNWHSV 414
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQG-LGAGALFPAALALIADWFPPEERGRALGL-VSAGFGLGAALGPLLGGLLASLF--GWRAA 153
|
170 180
....*....|....*....|
gi 446300706 415 AIYLLAGCLISAITALLMKD 434
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRP 173
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
78-208 |
8.25e-05 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 44.59 E-value: 8.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 78 PLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFStigwwapiLLVTLRAIQGFAVGGEWGGAALLSVESAPKN 157
Cdd:cd17374 49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFP--------VYCVLRFLAGFAVSGISINTLILGTEWTTPR 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 446300706 158 KKAFYSSGVQVGYGVGLLLSTGLVSLISmmttDEQFLSWGWRIPFLFSIVL 208
Cdd:cd17374 121 HRALAITLTSCFFSIGQMLLAGLAYAIR----DWRLLQLVVSVPFFLFFLY 167
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
41-352 |
1.06e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 44.15 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 41 YGITAALVFNREFFpQVSPAMGTLAAFAtFGVGFLfrpLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFsti 120
Cdd:cd17328 16 FTIAGVLPDIQSDF-LIDDSLAGLLQTV-FIISYM---VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF--- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 121 gWWapilLVTLRAIQGFAVGGEWGGAALLSVESAPKNKK----AFYSSGVQVGYGVGLLLSTGLVSLIsmmttdeqfLSW 196
Cdd:cd17328 88 -WQ----LLLFRALVGIGEASYSPIAPTIIADLFPKEKRtralGVFYFAIPLGSGLGYVVGGLVAQAT---------GGW 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 197 GW--RIPFLFSIVLVLGALWVRnGMEESAEFEQQQHNQAAAKKRIPVIEALLRHPgAFLKIIALRLCELLTMYIVTAFAL 274
Cdd:cd17328 154 RWafRVTGVLGVLLAILLLLFV-REPPRGAAEGGVMAKSTATSFLADLKALAKNP-SFILSTLGFTAVSFVTGALAFWAP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 275 NYSTQNMGLPRELFLNIGLLVGGLSCLT----IPCFAWLADRFGRR--RVYITGALIGTLSAFPF-FMALEAQSIFWIVF 347
Cdd:cd17328 232 TFFLRAFGVGDLSSADVGLIFGAITCIAgvlgVLLGGILADRLRRKtpRADPLVCAVGLLAAAPFlFLALVLALSNLLLA 311
|
....*
gi 446300706 348 FSIML 352
Cdd:cd17328 312 WVLLF 316
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
79-407 |
1.19e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 44.10 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 79 LGGVIFGHFGDRLGRKRMLMLTvwmmGIATALIGILPSFSTIGWWapilLVTLRAIQGFAVGGEWGGAALLSVESAPKNK 158
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLIS----AVLFFISALGSAFSPNFTI----FIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 159 KAFYSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLF----SIVLVLGALwvrnGMEESAEFeqqqhnQAA 234
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLeaipAILFLLGML----FIPESPRW------LVS 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 235 AKKRIPVIEALLrhpGAFLKIIALRLcelltmyivtafALNYST---QNMGLPRE--LFLNIGllVGGLSCLTIPCFAWL 309
Cdd:cd17359 193 KGKPILIIGIGL---AIFQQFVGINV------------IFYYGPeifQNAGFSENaaLLQTIG--IGVVNVIFTIIAILL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 310 ADRFGRRRVYITGALIGTLS----AFPFFMALEAQSIFWIVFFSIMLANIAHDMVVC-VQQPMFTEMFGASYRYSGAGVg 384
Cdd:cd17359 256 VDKVGRKPLLLIGSIGMAISllliGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGpVTWVLLSEIFPNRIRGLAMGI- 334
|
330 340
....*....|....*....|...
gi 446300706 385 yqvasvvgGGFTPFIAAALITYF 407
Cdd:cd17359 335 --------AVFFLWIANFLVSLT 349
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
68-402 |
1.33e-04 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 43.89 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 68 ATFGVGFLFrplGGVIFGHFGD-RLGRKRMLMLTVwmmgIATALIGILPSFSTIGWwapiLLVTLRAIQGFAVGGEWGGA 146
Cdd:cd17378 40 SSFFVGCLI---GSGVLGHLADsSLGRKNLLFLSC----LLMALSGIATAFSPNYW----VYAFLRFLTGFGRSGIGTCA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 147 ALLSVESAPKNKKAfyssgvQVGYGVGLLLSTGLVSLISMmttdEQFLSWGWRIPFLFSIVlvlgalwvrngmeesaefe 226
Cdd:cd17378 109 LVLATEPVGPKWRG------QVGMSTFFFFVLGFMSLPGI----AYLNGSSWRVLYFWTSI------------------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 227 qqqhnqaaakkripvieallrhPGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLP-RELFLNIGLLVGGLSCLTIPC 305
Cdd:cd17378 160 ----------------------PALIYCILVYLFARRLLAVMVIGFGIGMVYYGIPLAvGNLKFNIYLSVALNALSELPA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 306 F---AWLADRFGRRRVYITGALIGTLS-----AFPFFMALEAQSIFWIVffSIMLANIAHDMVVcvqqpMFT-EMFGASY 376
Cdd:cd17378 218 FvitAFLLDRFGRRPSLLGFTLLSGAScllcfVLSIGGTTSLQIALELV--GFFGAAGAFNLLY-----IYTvELFPTCV 290
|
330 340
....*....|....*....|....*.
gi 446300706 377 RYSGAGVGYQvASVVGGGFTPFIAAA 402
Cdd:cd17378 291 RNAALGMLRQ-ALVVGGIFAPFIVSL 315
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
82-215 |
1.74e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 43.70 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 82 VIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSfstigwwaPILLVTLRAIQGFavggewGGAALLSVESA------P 155
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGI------GAAAIMPASLAliaatfP 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446300706 156 KNKK----AFYSSGVQVGYGVGLLLSTGLVSLismmttdeqflsWGWRIPFLFSIVLVLGALWV 215
Cdd:cd17321 115 GERRgralGLWGAVVGIGAALGPLLGGLLLEL------------FGWRWIFLINVPIGLVALLL 166
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
79-436 |
2.33e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.32 E-value: 2.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 79 LGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFStigwwapiLLVTLRAIQGFAVGGewGGAALLSV--ESAPK 156
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVA--------LLLAGTALIGAGIAV--GNVLLPGLikRWFPD 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 157 NKK---AFYSSGVQVGYGVGLLLSTGLVSlismmttdeqflSWGWRIPFLFSIVLVLGALWVRngmeeSAEFEQQQHNQA 233
Cdd:COG2807 138 RVGlmtGLYTAAMGLGAALAAGLTVPLAA------------ALGWRGALAVWALLALLALLLW-----LPLLRRRPAAAA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 234 AAKKRIPVIeALLRHPGAFLKIIALRLCeLLTMYIVTAFALNYSTQNmGLPRE---LFLNIGLLVGGLSCLTIPcfaWLA 310
Cdd:COG2807 201 AAPAAASLR-SLWRSPLAWLLTLFFGLQ-SLLYYAVVAWLPPILRDA-GLSAAtagLLLSLFQLAGIPGSLLVP---LLA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 311 DRFGRRRVYITGALIGTLSAFPFFMALEAQS-IFWIVFFSIMLANIahdMVVCvqqPMFTEMFGASYRYSGAGVGY-QVA 388
Cdd:COG2807 275 DRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLpWLWAVLLGLGQGGL---FPLA---LTLIGLRARTPAEAAALSGMaQSV 348
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446300706 389 SVVGGGFTPFIAAALITYFaGNWHSVAIYLLAGCLISAITALLMKDNQ 436
Cdd:COG2807 349 GYLLAALGPLLVGALHDAT-GSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
70-432 |
3.21e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.56 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 70 FGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTigwwapilLVTLRAIQGFAVGGEWGGAALL 149
Cdd:cd17319 44 ASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVAEAGFFPGAIKA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 150 SVESAPKNKKA----FYSSGVQVGYGVGLLLSTGLVSLismmttdeqflsWGWRIPFLFS--IVLVLGALWVRngmeesa 223
Cdd:cd17319 116 LAEWFPARERGratgLFNSGAPLGAAIGPPLSGWLLLL------------FGWRWAFIIEglLGLLLAVLWWF------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 224 efeqqqhnqaaakkripvieaLLRHpgaFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRE---LFLNIGLLVGGLSC 300
Cdd:cd17319 177 ---------------------YLRQ---VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKqvgLLAAIPFLAGAIGM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 301 LTIPcfaWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFWIVFFsIMLANIAHDMVVCVQQPMFTEMFGASYRYSG 380
Cdd:cd17319 233 ILGG---RLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVIL-LSLAGFGIGAASPVFWSLPADLLPGEAAATA 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446300706 381 AGVgYQVASVVGGGFTPFIAAALITYFaGNWHSVAIYLLAGCLISAITALLM 432
Cdd:cd17319 309 GGL-INSGGNLGGFVAPLLIGYLVDAT-GSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
68-350 |
3.52e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 42.63 E-value: 3.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 68 ATFGVGFLFrplGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGilpsFSTIgWWAPILLVTLRAIQGFAVGGEWGGAA 147
Cdd:cd17357 56 SIFFIGGAI---GSFISAFLANRFGRKNGLLISNALLVVSSLLMF----LSKS-AKSPELLIFGRFLVGIACGLSTGFVP 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 148 LLSVESAPKNKKAFYSSGVQVGYGVGLLLsTGLVSLISMMTTDEQflswgWRIPFLFSIVLVLGALWVRNGMEESAEF-E 226
Cdd:cd17357 128 MYLQEISPSELRGALGSLTQIGVTLGILL-GQVFGLPSVLGTETL-----WPYLLFFPGIPALLQLAALPFFPESPKFlL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 227 QQQHNQAAAKKRI--------PVIEALLRHPGAFLKII---ALRLCELLT-------MYIVTAFALN-----------YS 277
Cdd:cd17357 202 ISKGDEEEAEKSLkflrgiedDVDQELEEIKKESEQMGdqkQVSLMQLLRdpslrlpLLLVLVVSASqqfsginaiffYS 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 278 T---QNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGA--LIGTLSAFPFFMALEAQSIFW----IVFF 348
Cdd:cd17357 282 TfifENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLsvCAVALLLMSVFLFLSEQNSWMsygcIVAI 361
|
..
gi 446300706 349 SI 350
Cdd:cd17357 362 FL 363
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
79-432 |
5.71e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.83 E-value: 5.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 79 LGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTIGWWApillvtlrAIQGFAVG-GEWGGAALLSVESAPKN 157
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL--------VLTGFGGGlFEPASEAMIADVTTPEN 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 158 KKAFYSS---GVQVGYGVGLLLSTGLVSLismmttdeqflswGWRIPFLF-SIVLVLGALWVRNGMEESAEFEQQQHNQA 233
Cdd:cd17329 122 RTRAFSLlywAINLGVAIGPLLGGLLLLY-------------SFRLLFLAaAVLFLLAALVLLFLLPETRPKRRAAEKTE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 234 AAKKRIPViealLRHPGAFLKIIALRLCELLTMYIVTAFALnYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRF 313
Cdd:cd17329 189 ILRGYKIV----LRDRAFLLFLLASFLISLIYFQLESTLPV-YVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERF 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 314 GRRRVYITGALIGTLSAFPFFMAleaqSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYR--YSGAgvgYQVASVV 391
Cdd:cd17329 264 RLRKILMIGILLFAIGFAVLAFA----NTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRgsYMGF---YALAWGL 336
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 446300706 392 GGGFTPFIAAALITYFAGNWhsVAIYLLAGCLISAITALLM 432
Cdd:cd17329 337 GRAIGPLVGGLLLDLLGPGL--PWLILAALGLIAAALLLGL 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
267-432 |
6.55e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.64 E-value: 6.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 267 YIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMAleaqSIFWIV 346
Cdd:cd06174 12 RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA----PSFWLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 347 FFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVgYQVASVVGGGFTPFIAAALITYFAGNWHSVAIYLLAGCLISA 426
Cdd:cd06174 88 LLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGL-LQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAA 166
|
....*.
gi 446300706 427 ITALLM 432
Cdd:cd06174 167 ILLLLV 172
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
61-215 |
6.73e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.79 E-value: 6.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 61 MGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFstigwwapILLVTLRAIQGFAVG 140
Cdd:cd17325 232 LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF--------WLLLLLLALLGLGLG 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446300706 141 GEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMmttdeqflSWGWRIPFLFSIVLVLGALWV 215
Cdd:cd17325 304 LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD--------AFGFATPFLAAAALLLLAAVL 370
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
67-213 |
2.11e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 38.40 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 67 FATFGVGFLFrplGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTigwwapilLVTLRAIQGFAVGGEWGGA 146
Cdd:TIGR00880 4 LAGYALGQLI---YSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITV--------LIIARFLQGFGAAFALVAG 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446300706 147 ALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMttdeqflsWGWRIPFLFSIVLVLGAL 213
Cdd:TIGR00880 73 AALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQF--------LGWRAPFLFLAILALAAF 131
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
58-432 |
2.36e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.88 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 58 SPAMGTLAAFATFGVGFLFRPLGGVIfghfGDRLGRKRMLMLTVWMMGIATALIGILPSfstigwwaPILLVTLRAIQGF 137
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRL----LDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 138 AVGGEWGGAALLSVESAPKNKKA----FYSSGVQVGYGVGLLLSTGLVSLismmttdeqflsWGWRIPFLFSIVLVLGAL 213
Cdd:cd17489 97 GWGAFTTAAATLVADIIPPSRRGegigYYGLATTLAMALGPALGLFLYQH------------LGFAVLFIVAAVLALLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 214 WVRNGMEEsAEFEQQQHNQAAAKKRIPVIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYStqnmglprelflNIGL 293
Cdd:cd17489 165 LLVFLVKD-PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS------------NAGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 294 ---LVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSafpfFMALEAQSIFWIVFFSIMLANIAHDMVvcvqQPMFTE 370
Cdd:cd17489 232 fftVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG----LLLLSFAGSPWMLLLAAVLYGLGFGLL----FPALQA 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446300706 371 MFGASYRYSGAGVG---YQVASVVGGGFTPFIAAALITYFAgnwhSVAIYLLAGCLISAITALLM 432
Cdd:cd17489 304 LAVDLVPPHRRGAAngtFFIFFDLGIGLGGLLLGLVAELFG----YRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
299-431 |
3.06e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.92 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 299 SCLTIPCFAWLADRFGRRRVYITGALIGTLSafpFFMALEAQSIFWIVFFSIMLAnIAHDMVVCVqQPMFTEMFGASYRY 378
Cdd:cd06179 45 QAVLGPIVGRLSDLFGRRWFFIGGNLLGVVG---SIVAGTAKSVNMLIGGQALIG-IGAGTQGLG-AAVASELVPNKYRG 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 446300706 379 SGAGVGYqVASVVGGGFTPFIAAALITYFAGNWHSVaIYLLAGclISAITALL 431
Cdd:cd06179 120 LVQGVVN-LVASPGSALGPLIAGALVEANAAGWRWI-FYINAI--FNALALIL 168
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
32-332 |
3.21e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 39.52 E-value: 3.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 32 VVDWYDFLLYGITAALVFnrEFFPQVSPAMGTLAAFA-------TFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMM 104
Cdd:PRK09874 17 TVAWLGCFLTGAAFSLVM--PFLPLYVEQLGVTGHSAlnmwsglVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGM 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 105 GIATALIGILPSFstigwWApilLVTLRAIQGFaVGGEWGGAALLSVESAPKNKKafyssgvqvGYGVGlLLSTGLVS-- 182
Cdd:PRK09874 95 GIVMVLMGLAQNI-----WQ---FLILRALLGL-LGGFVPNANALIATQVPRNKS---------GWALG-TLSTGGVSga 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 183 LISMMTTDEQFLSWGWRIPFLFS-----IVLVLGALWVRNGMEESAEFEQQQHNQAAAKKRIPVIEALLRHPGAFLKIIA 257
Cdd:PRK09874 156 LLGPLAGGLLADSYGLRPVFFITasvlfLCFLVTLFCIRENFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVAT 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446300706 258 LRLCELLTMYiVTAFALNYStqNMGLPRELflnIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFP 332
Cdd:PRK09874 236 GSIAPILTLY-VRELAGNVS--NIAFISGM---IASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIP 304
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
288-411 |
3.55e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 39.26 E-value: 3.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 288 FLNIGLLVGGLScltipcFAWLADRFGRRRVYITGALI----GTLSAFpffmaleAQSIFWIVFFSIMLANIAHD--MVV 361
Cdd:cd17379 41 SLNLGFLIGSIV------IGYLADRFGRKVCFLISILGngvsGVLMAF-------SPNYPWFLIFRFLQGLFGKGgwMTG 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 446300706 362 CVqqpMFTEMFGASYRYSgAGVGYQVASVVGggftpFIAAALITYFAGNW 411
Cdd:cd17379 108 YV---LVTEFVGSKYRRT-VGIVYQMFFTLG-----LLILPGIAYFIPHW 148
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
79-205 |
3.93e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 39.32 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 79 LGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFStigwwapiLLVTLRAIQGFAVGGEWGGAALLSVESAPKNK 158
Cdd:cd17446 48 VGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFP--------IYCVFRFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 446300706 159 KAFYSSGVQVGYGVGLLLSTGLVSLISmmttDEQFLSWGWRIPFLFS 205
Cdd:cd17446 120 RAVVGTLLGYCYTLGQLILAGVAYAIR----DWRWLQLAVSLPFFIF 162
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
79-210 |
4.39e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 39.26 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 79 LGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFStigwwapiLLVTLRAIQGFAVGGEWGGAALLSVESAPKN- 157
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHi 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 158 -------KKAFYSSGVQVGYGVGLLLSTglvslismmttdeqfLSWGWRIPFLFSIVLVL 210
Cdd:cd17362 126 rgllvslKELFIVLGILLGYVSGYAFAD---------------VVGGWRYMYGLAAPPAL 170
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
79-184 |
5.89e-03 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 38.56 E-value: 5.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446300706 79 LGGVIFGHFGDRLGRKRMLMLTVwmmgIATALIGILPSFSTigwwAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNK 158
Cdd:cd17447 50 MGAVAFGYLSDRFGRKRMLLVAY----VLSLVFGLASAFSV----SYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEH 121
|
90 100
....*....|....*....|....*.
gi 446300706 159 KAFYSSGVQVGYGVGLLLSTGLVSLI 184
Cdd:cd17447 122 RTVAGVLISLFWTVGNMLLALVAYLI 147
|
|
| |
