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Conserved domains on  [gi|446301783|ref|WP_000379638|]
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MULTISPECIES: PTS lactose/cellobiose transporter subunit IIA [Bacillus]

Protein Classification

PTS lactose/cellobiose transporter subunit IIA( domain architecture ID 10491527)

PTS lactose/cellobiose transporter subunit IIA helps catalyze the phosphorylation of incoming sugar substrates leading to their translocation across the cell membrane; similar to Bacillus subtilis Lichenan-specific phosphotransferase enzyme IIA component

CATH:  1.20.58.280
Gene Ontology:  GO:0009401|GO:0016740
SCOP:  3001316
TCDB:  4.A.3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 8-99 1.93e-47

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


:

Pssm-ID: 460510  Cd Length: 94  Bit Score: 146.42  E-value: 1.93e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446301783    8 AFHLILHGGNARSCSMEAIDCAKRGEFTEAEAKLQEALEELKEAHRVQTDLIQKEAGGEKTEVTLLMVHAQDHLMNAITV 87
Cdd:pfam02255   3 AMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAMTE 82

                          90
                  ....*....|..
gi 446301783   88 KELASEFVELYR 99
Cdd:pfam02255  83 KDLAKELIELYK 94
 
Name Accession Description Interval E-value
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 8-99 1.93e-47

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 460510  Cd Length: 94  Bit Score: 146.42  E-value: 1.93e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446301783    8 AFHLILHGGNARSCSMEAIDCAKRGEFTEAEAKLQEALEELKEAHRVQTDLIQKEAGGEKTEVTLLMVHAQDHLMNAITV 87
Cdd:pfam02255   3 AMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAMTE 82

                          90
                  ....*....|..
gi 446301783   88 KELASEFVELYR 99
Cdd:pfam02255  83 KDLAKELIELYK 94
CelC COG1447
Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and ...
 5-102 3.00e-47

Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 441056  Cd Length: 100  Bit Score: 146.44  E-value: 3.00e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446301783   5 ETKAFHLILHGGNARSCSMEAIDCAKRGEFTEAEAKLQEALEELKEAHRVQTDLIQKEAGGEKTEVTLLMVHAQDHLMNA 84
Cdd:COG1447    1 EEIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKVQTELIQKEAGGEKVEVSLLLVHAQDHLMTA 80

                         90
                 ....*....|....*...
gi 446301783  85 ITVKELASEFVELYRKMS 102
Cdd:COG1447   81 MTEKDLAKELIELYKKLE 98
PTS_IIA_lac cd00215
PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial ...
 4-100 7.41e-41

PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 238133  Cd Length: 97  Bit Score: 130.02  E-value: 7.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446301783   4 IETKAFHLILHGGNARSCSMEAIDCAKRGEFTEAEAKLQEALEELKEAHRVQTDLIQKEAGGEKTEVTLLMVHAQDHLMN 83
Cdd:cd00215    1 LELISFQIILHAGNARSKALEALKAAKEGDFAEAEELLEEANDSLNEAHHAQTKLLQQEASGEKVEVSLLLVHAQDHLMT 80

                         90
                 ....*....|....*..
gi 446301783  84 AITVKELASEFVELYRK 100
Cdd:cd00215   81 TITLKDLAKEMIELYKK 97
EIIA-LAC TIGR00823
phosphotransferase system enzyme II, lactose-specific, factor III; The PTS Lactose-N,N? ...
 2-100 8.01e-37

phosphotransferase system enzyme II, lactose-specific, factor III; The PTS Lactose-N,N?-Diacetylchitobiose-b-glucoside (Lac) Family (TC 4.A.3)Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Lac family includes several sequenced lactose (b-galactoside) permeases of Gram-positive bacteria as well as the E. coli N,N?-diacetylchitobiose (Chb)permease which can transport aromatic b-glucosides and cellobiose as well as the chitin disaccharide, Chb, but only Chb induces expression of the chboperon. While the Lac permeases consist of two polypeptide chains (IIA and IICB), the Chb permease of E. coli consists of three (IIA, IIB and IIC). In B. subtilis, a PTS permease similar to the Chb permease of E. coli is believed to transport lichenan (a b-1,3;1,4 glucan) degradation products, oligosaccharides of 2-4 glucose units. This model is specific for the IIA subunit of the Lac PTS family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129903  Cd Length: 99  Bit Score: 119.85  E-value: 8.01e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446301783    2 DTIETKAFHLILHGGNARSCSMEAIDCAKRGEFTEAEAKLQEALEELKEAHRVQTDLIQKEAGGEKTEVTLLMVHAQDHL 81
Cdd:TIGR00823   1 EEMELLGFEIVAYAGDARSKALEALKAAKAGDFAKARALVEQAGMCINEAHLAQTSLLAQEAGGGKMEVSLTMVHGQDHL 80

                          90
                  ....*....|....*....
gi 446301783   82 MNAITVKELASEFVELYRK 100
Cdd:TIGR00823  81 MTTILLKDLAAELIELYKR 99
celC PRK09591
PTS cellobiose transporter subunit IIA;
2-101 1.21e-24

PTS cellobiose transporter subunit IIA;


Pssm-ID: 181975  Cd Length: 104  Bit Score: 89.47  E-value: 1.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446301783   2 DTIETKAFHLILHGGNARSCSMEAIDCAKRGEFTEAEAKLQEALEELKEAHRVQTDLIQKEAGGEKTEVTLLMVHAQDHL 81
Cdd:PRK09591   4 EELQVAAFEIILHSGNARTEVHEAFAAMREGNFDLAEQKLNQSNEELLEAHHAQTKLLQEYASGTEIKIEIIMVHAQDHL 83

                         90       100
                 ....*....|....*....|
gi 446301783  82 MNAITVKELASEFVELYRKM 101
Cdd:PRK09591  84 MTTMTLREVAKEMLALYKKV 103
 
Name Accession Description Interval E-value
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 8-99 1.93e-47

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 460510  Cd Length: 94  Bit Score: 146.42  E-value: 1.93e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446301783    8 AFHLILHGGNARSCSMEAIDCAKRGEFTEAEAKLQEALEELKEAHRVQTDLIQKEAGGEKTEVTLLMVHAQDHLMNAITV 87
Cdd:pfam02255   3 AMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAMTE 82

                          90
                  ....*....|..
gi 446301783   88 KELASEFVELYR 99
Cdd:pfam02255  83 KDLAKELIELYK 94
CelC COG1447
Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and ...
 5-102 3.00e-47

Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 441056  Cd Length: 100  Bit Score: 146.44  E-value: 3.00e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446301783   5 ETKAFHLILHGGNARSCSMEAIDCAKRGEFTEAEAKLQEALEELKEAHRVQTDLIQKEAGGEKTEVTLLMVHAQDHLMNA 84
Cdd:COG1447    1 EEIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKVQTELIQKEAGGEKVEVSLLLVHAQDHLMTA 80

                         90
                 ....*....|....*...
gi 446301783  85 ITVKELASEFVELYRKMS 102
Cdd:COG1447   81 MTEKDLAKELIELYKKLE 98
PTS_IIA_lac cd00215
PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial ...
 4-100 7.41e-41

PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 238133  Cd Length: 97  Bit Score: 130.02  E-value: 7.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446301783   4 IETKAFHLILHGGNARSCSMEAIDCAKRGEFTEAEAKLQEALEELKEAHRVQTDLIQKEAGGEKTEVTLLMVHAQDHLMN 83
Cdd:cd00215    1 LELISFQIILHAGNARSKALEALKAAKEGDFAEAEELLEEANDSLNEAHHAQTKLLQQEASGEKVEVSLLLVHAQDHLMT 80

                         90
                 ....*....|....*..
gi 446301783  84 AITVKELASEFVELYRK 100
Cdd:cd00215   81 TITLKDLAKEMIELYKK 97
EIIA-LAC TIGR00823
phosphotransferase system enzyme II, lactose-specific, factor III; The PTS Lactose-N,N? ...
 2-100 8.01e-37

phosphotransferase system enzyme II, lactose-specific, factor III; The PTS Lactose-N,N?-Diacetylchitobiose-b-glucoside (Lac) Family (TC 4.A.3)Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Lac family includes several sequenced lactose (b-galactoside) permeases of Gram-positive bacteria as well as the E. coli N,N?-diacetylchitobiose (Chb)permease which can transport aromatic b-glucosides and cellobiose as well as the chitin disaccharide, Chb, but only Chb induces expression of the chboperon. While the Lac permeases consist of two polypeptide chains (IIA and IICB), the Chb permease of E. coli consists of three (IIA, IIB and IIC). In B. subtilis, a PTS permease similar to the Chb permease of E. coli is believed to transport lichenan (a b-1,3;1,4 glucan) degradation products, oligosaccharides of 2-4 glucose units. This model is specific for the IIA subunit of the Lac PTS family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129903  Cd Length: 99  Bit Score: 119.85  E-value: 8.01e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446301783    2 DTIETKAFHLILHGGNARSCSMEAIDCAKRGEFTEAEAKLQEALEELKEAHRVQTDLIQKEAGGEKTEVTLLMVHAQDHL 81
Cdd:TIGR00823   1 EEMELLGFEIVAYAGDARSKALEALKAAKAGDFAKARALVEQAGMCINEAHLAQTSLLAQEAGGGKMEVSLTMVHGQDHL 80

                          90
                  ....*....|....*....
gi 446301783   82 MNAITVKELASEFVELYRK 100
Cdd:TIGR00823  81 MTTILLKDLAAELIELYKR 99
celC PRK09591
PTS cellobiose transporter subunit IIA;
2-101 1.21e-24

PTS cellobiose transporter subunit IIA;


Pssm-ID: 181975  Cd Length: 104  Bit Score: 89.47  E-value: 1.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446301783   2 DTIETKAFHLILHGGNARSCSMEAIDCAKRGEFTEAEAKLQEALEELKEAHRVQTDLIQKEAGGEKTEVTLLMVHAQDHL 81
Cdd:PRK09591   4 EELQVAAFEIILHSGNARTEVHEAFAAMREGNFDLAEQKLNQSNEELLEAHHAQTKLLQEYASGTEIKIEIIMVHAQDHL 83

                         90       100
                 ....*....|....*....|
gi 446301783  82 MNAITVKELASEFVELYRKM 101
Cdd:PRK09591  84 MTTMTLREVAKEMLALYKKV 103
PRK10454 PRK10454
PTS N,N'-diacetylchitobiose transporter subunit IIA;
2-102 7.48e-22

PTS N,N'-diacetylchitobiose transporter subunit IIA;


Pssm-ID: 182472  Cd Length: 115  Bit Score: 82.63  E-value: 7.48e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446301783   2 DTIETKAFHLILHGGNARSCSMEAIDCAKRGEFTEAEAKLQEALEELKEAHRVQTDLIQKEAGGEKTEVTLLMVHAQDHL 81
Cdd:PRK10454  15 EELEEVVMGLIINSGQARSLAYAALKQAKQGDFAAAKAMMDQSRMALNEAHLVQTKLIEGDQGEGKMKVSLVLVHAQDHL 94

                         90       100
                 ....*....|....*....|.
gi 446301783  82 MNAITVKELASEFVELYRKMS 102
Cdd:PRK10454  95 MTSMLARELITELIELHEKLK 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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