|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
23-426 |
5.07e-100 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 302.57 E-value: 5.07e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 23 FRLMPFLMLCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGIL 102
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 103 SGCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMdrmsgvhGWF 182
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL-------LLF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 183 GWQWMFVIEAIPTVLVGLLVlavlkdsvqeanwltqdeknlvkqelaqdnqhkeghasvkeFIADKRLWLLAGIYFCVVM 262
Cdd:cd17319 155 GWRWAFIIEGLLGLLLAVLW-----------------------------------------WFYLRQVWGLALGYFGINY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 263 GQYAITFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHF--QERRWHLIIPMCAGAIALTFATlFASNLT 340
Cdd:cd17319 194 ALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAY-LTTSPV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 341 LSLICLCIAASGVLTASSLFWMLPTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAIGMFLITAVLIFGA 420
Cdd:cd17319 273 VAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAA 352
|
....*.
gi 446304029 421 SLVLRV 426
Cdd:cd17319 353 LLVLLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
31-426 |
3.82e-89 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 276.14 E-value: 3.82e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 31 LCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQ 110
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 111 TEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMdrmsgVHgwFGWQWMFVI 190
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWIL-----IH--FSWQWAFII 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 191 EAIPTVLVGLLVLAVLKDSVQEANWLTQDEKNLVKQELAQDNQHKEGH----ASVKEFIADKRLWLLAGIYFCVVMGQYA 266
Cdd:TIGR00893 154 EGVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPStpkkYQIKELLKDRRVWGLALGQFLVNIGLGF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 267 ITFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWHLIIPMCAGAIALTFATL---FASNLTLSL 343
Cdd:TIGR00893 234 FLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLlmfATNYVNIPY 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 344 ICLCIAASGV--LTASSLFWMLPTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAIGMFLITAVLIFGAS 421
Cdd:TIGR00893 314 AALALVALGFfgLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGAL 393
|
....*
gi 446304029 422 LVLRV 426
Cdd:TIGR00893 394 SYLLL 398
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-430 |
3.22e-70 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 225.90 E-value: 3.22e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 15 KSAYRKIAFRLMPFLMLCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIAR 94
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 95 IMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDr 174
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 175 msgvhgWFGWQWMFVIEAIPTVLVGLLvlavlkdsvqeanwltqdeknlvkqelaqdnqhkeghasvkefiadkRLWLLA 254
Cdd:COG2271 160 ------AFGWRAAFLILGLPGLLLALL-----------------------------------------------RFWLLA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 255 GIYFCVVMGQYAITFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWHLIIPMCAGAIALTFATL 334
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 335 FASNLTLSLICLCIAASGVLTASSLFWMLPTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAiGMFLITA 414
Cdd:COG2271 267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA-AFLLLAA 345
|
410
....*....|....*.
gi 446304029 415 VLIFGASLVLRVPAKL 430
Cdd:COG2271 346 LALLAALLALLLLRET 361
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
20-394 |
1.46e-57 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 194.39 E-value: 1.46e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 20 KIAFRLMPFLMLCYFCAYLDRVNVGFAKLQ-MMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMIT 98
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 99 WGILSGCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLS-GLImdRMSG 177
Cdd:cd17327 81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAyGVF--KILG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 178 VHGWFGWQWMFVIEAIPTVLVGLLVLAVLKDSVQEANWLTQDEKNLVKQELAQDNQHKEGHAS----VKEFIADKRLWLL 253
Cdd:cd17327 159 VGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFkwkqIKEAFKDPRTWLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 254 AGIYFCVVMGQYAITFWLPTLIrNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWHLIIpMCAGAIALTFAT 333
Cdd:cd17327 239 FLFFFCSQITNNGISNFLPLIL-KSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIF-ACVLALVGSIIL 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446304029 334 LFASNLTLSLICLCIAASGVLTASSLFWMLPTNFLGGVSA-AAGIAAVNSFANLAGFCSPYL 394
Cdd:cd17327 317 LAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKrATVLAIMLIFYNVGNIVAPQI 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-429 |
2.20e-43 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 156.58 E-value: 2.20e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 20 KIAFRLMPFLMLCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITW 99
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 100 GILSGCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMdrmsgvh 179
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI------- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 180 GWFGWQWMFVIEAIPTVLVGLLVLAVLKDSVQEANwltqdeknlvkqelaqdNQHKEGHASVKEFIADKRLWLLAGIYFC 259
Cdd:COG2223 154 AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAA-----------------AAAKASLRDQLEALRDPRFWLLSLLYFG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 260 VVMGQYAITFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWHLIIPMCAGAIALTFATLFASNL 339
Cdd:COG2223 217 TFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 340 TLSLICLCIAASGVLTASSLFWMLPTNFlGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAIGMFLITAVLIFG 419
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPDIF-PTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVA 375
|
410
....*....|
gi 446304029 420 ASLVLRVPAK 429
Cdd:COG2223 376 LVLTLLLYRR 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
29-424 |
5.43e-29 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 116.76 E-value: 5.43e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 29 LMLCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAF 108
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 109 VQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDrmsgvHGWFGWQWMF 188
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS-----SLGFGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 189 VIEAIPTVLVGLLVLAVLKDSVQEAnwltqdeknlvkQELAQDNQHKEGHASVKEFIADKRLWLLAGIYFCVVMGQYAIT 268
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESA------------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 269 FWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWHLIIpMCAGAIALTFATLFASNLTLSLICLCI 348
Cdd:cd06174 224 TLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI-GLLLMALGLALLLLAPSLLLLLLLLLL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446304029 349 AASGVLTASSLFWMLPTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAIGMFLITAVLIFGASLVL 424
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-388 |
3.09e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 111.22 E-value: 3.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 16 SAYRKIAFRLMPFLMLCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARI 95
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 96 MITWGILSGCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDrm 175
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 176 sgvhgWFGWQWMFVIEAIPTVLVGLLVLAVLKDSVQEAnwltqdeknlvkqelaqdnqHKEGHASVKEFIADKRLWLLAG 255
Cdd:COG2814 160 -----LFGWRWVFLVNAVLALLALLLLLRLLPESRPAA--------------------RARLRGSLRELLRRPRLLLLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 256 IYFCVVMGQYAITFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRwhLIIPMCAGAIALTFATLF 335
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR--LLLIGLLLLALGLLLLAL 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446304029 336 ASNLTLSLICLCIAASGVLTASSLFWMLPTNFLGGVSAAAGIAAVNSFANLAG 388
Cdd:COG2814 293 AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-392 |
4.53e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 110.59 E-value: 4.53e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 29 LMLCYFCAYLDRVNVGFA-KLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFA 107
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 108 FVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDrmsgvhgWFGWQWM 187
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-------LFGWRAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 188 FVIEAIPTVLVGLLvlavlkdsvqeanWLTQDEKNLVKQELAQDNQHKEGHASVKEFIADKRLWLLAGIyFCVVMGQYAI 267
Cdd:pfam07690 154 FLILAILSLLAAVL-------------LLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 268 TFWLPTLIRNSGISdNWHIGLLTSLPYMCAIVVMILAGRSGDHFQ-ERRWHLIIPMCAGAIALTFATLFASNLTLSLICL 346
Cdd:pfam07690 220 LTYLPLYQEVLGLS-ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446304029 347 CIAASGVLTASSLFWMLPTNFLGGVSAAAGIAAVNSFANLAGFCSP 392
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
49-431 |
1.97e-20 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 92.63 E-value: 1.97e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 49 QMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARR--WIARIMITWGILSgcFAFVQTEWQFYTLRFLLGVAE 126
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERtlLLALLLLAAGLLL--RSLAPSVALLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 127 AGLAPGLLLYLTYWFPSyRRARMTVLWFIAIPISGMIGGPLSGLIMDrmsgvhgWFGWQWMFVIEAIPTVLVGLLvlavl 206
Cdd:COG2807 121 AVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAA-------ALGWRGALAVWALLALLALLL----- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 207 kdsvqeanWLtqdeknLVKQELAQDNQHKEGHASVKEFIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDNwHI 286
Cdd:COG2807 188 --------WL------PLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAA-TA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 287 GLLTSLPYMCAIVVMILAGRSGDHFQERRWHLIIpmCAGAIALTFATLFASNLTLSLICLCIAASGVLTASSLFWMLPTN 366
Cdd:COG2807 253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLL--LGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGL 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446304029 367 FLGGV-SAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAIGMFLITAVLIFGASLVLRVPAKLV 431
Cdd:COG2807 331 RARTPaEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPYV 396
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
33-403 |
1.73e-19 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 89.36 E-value: 1.73e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 33 YFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQTE 112
Cdd:TIGR00881 4 YAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 113 WQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDRMsgvhgwFGWQWMFVIEA 192
Cdd:TIGR00881 84 WVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAEL------YSWHWVFIVPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 193 IPTVLVGLLVLAVLKDSVQ-----EANWLTQDEKNLVKQELAQDNQHKEGhaSVKEFIADKRLWLLAGIYFCVVMGQYAI 267
Cdd:TIGR00881 158 IIAIIVSLICFLLLRDSPQscglpPAEEMPNEEPDGDAEKKEEELTKKQI--FLQYVLLNKVLWYISLGYVFVYVVRTGI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 268 TFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWHLIIPMCAGAIALTFATLF---ASNLTLSLI 344
Cdd:TIGR00881 236 LDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWlnpAANPLMDLI 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446304029 345 CLCIAASGVLTASSLFWMLPTNFlgGVSAAAGIAA--VNSFANLAGFCSPYLIGWVTTNTG 403
Cdd:TIGR00881 316 CLFALGFLVYGPQMLIGVIASEL--APKKAAGTAAgfVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
31-424 |
4.97e-19 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 88.10 E-value: 4.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 31 LCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQ 110
Cdd:cd17312 10 LGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFST 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 111 TEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMdrmsgvhGWFGWQWMFVI 190
Cdd:cd17312 90 SLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLA-------SYYGWRAAFLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 191 EAIPTVLVGLLVLAVLKDSvqeanwltqdeknlvkqelaqdnqhkeghasvkefiaDKRLWLLAGIYFCVVMGQYAITFW 270
Cdd:cd17312 163 PGIVGLVVAIILFFFLRDS-------------------------------------PPYVWVLSLAYAFVYIVRYACLDW 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 271 LPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWHLIIPMCAGAIALTFAT--LFASNLTLSLICLCI 348
Cdd:cd17312 206 GPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALfwFFPHNKLLSIVLLFL 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446304029 349 AASGVLTASSLFWMLPTNFLGGVSAAAGIAA-VNSFANLAGFCSPYLIGWVTTNTGSNAIGMFLITAVLIFGASLVL 424
Cdd:cd17312 286 IGFFVGGPINLIGGAAAQDIGRKEAAGTATGfVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLS 362
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
89-420 |
2.82e-18 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 85.73 E-value: 2.82e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 89 RRWIARI-MITWGILSGCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPL 167
Cdd:cd17316 65 RKKALILtLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 168 SGLIMDRMSGvhgWFGWQWMFVIEAIPTVLVgllvlavlkdsvqeanwltqdeknlvkqelaqdnqhkeghasvkeFIAD 247
Cdd:cd17316 145 ASLLIPLLSG---DWGWRILFLIGALPALLA---------------------------------------------LLLR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 248 KRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWHLIIPMCAGAI 327
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 328 ALTFATLFASNLTLSLICLCIAASGVLTASSLFWMLPTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAI 407
Cdd:cd17316 257 ALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGV 336
|
330
....*....|...
gi 446304029 408 GMFLITAVLIFGA 420
Cdd:cd17316 337 PALILALLAIVAL 349
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
51-424 |
1.66e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.39 E-value: 1.66e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 51 MSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAGLA 130
Cdd:cd17325 23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 131 PGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDrmsgvhgWFGWQWMFVIEAIPTVLVGLLVLAVLKDSV 210
Cdd:cd17325 103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD-------ALGYRAPFLVCAALALLALVLALLLLPEPR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 211 QEANwltqdeknlvkqelAQDNQHKEGHASVKEFIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDNWHIGLLT 290
Cdd:cd17325 176 PPPN--------------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 291 SLPYMCAIVVMILAGRSGDHFQERRWhLIIPMCAGAIALTFATLFASNLTLSLICLCIAASGVLTASSLFWMLPTNFLGG 370
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPL-ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446304029 371 VSAAAgIAAVNSFANLAGFCSPYLIGWVTTNTGsnAIGMFLITAVLIFGASLVL 424
Cdd:cd17325 321 GRGTA-MGLFNTAFSLGMVLGPLLGGFLYDAFG--FATPFLAAAALLLLAAVLF 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
49-425 |
2.54e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 83.36 E-value: 2.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 49 QMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAG 128
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 129 LAPGLLLYLTYWFPSYRRARMTVL--WFiaipisgMIGGPLSGLIMDRMSGVHGWFGWQWMFVIEAIPTVLVGLLVLAVL 206
Cdd:COG0738 113 LDVAANPYVAALGPETAASRLNLLhaFF-------SLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 207 kdsvqeanwltqdeknlVKQELAQDNQHKEGHASVKEFIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDNWHI 286
Cdd:COG0738 186 -----------------LPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 287 GLLTSLPYMCAIVVMILAGRSGDHFQERRwhLIIPMCAGAIALTFATLFASNLTLSLICLCIAASGVltasSLFWmlPTN 366
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVR--LLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGL----SLMF--PTI 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446304029 367 F-----LGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTG-SNAIGMFLITAVLIFGASLVLR 425
Cdd:COG0738 321 FslaldGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGlRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
37-420 |
1.65e-16 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 80.29 E-value: 1.65e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 37 YLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGC--FAFVQTEWQ 114
Cdd:cd17380 12 YADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLtpLLAYSSLPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 115 FYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDrmsgvhgWFGWQWMFVIEAIP 194
Cdd:cd17380 92 LILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE-------YYGWPSVFYFFGLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 195 TVLVGLLVlavlkdsvqeanwltqdeknlvkqelaqdnqhkeghasvkeFIADKRLWLLAGIYFCVVMGQYAITFWLPTL 274
Cdd:cd17380 165 GLLWALVW-----------------------------------------LIYLPPVWAIIVAHFCMNWGFYILLSWLPTY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 275 IrNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWHLI--------IPMCAGAIALTFATlFASNLTLSLICL 346
Cdd:cd17380 204 F-HEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTsvrklmqsIGFLGPALFLLLLS-HTDSFSLALLCM 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446304029 347 CIAASGVLTASSLFWMLPTNfLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAIGMFLITAVLIFGA 420
Cdd:cd17380 282 SVALGLSAFSSSGVLVNHQD-IAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGA 354
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
49-417 |
3.06e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 76.82 E-value: 3.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 49 QMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAG 128
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 129 LAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDrmsgvhgWFGWQWMFVIEAIPTVLVGLLVLAvlkd 208
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ-------LLGWRAAFLAIAVLALLAALLLWR---- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 209 svqeanwltqdeknLVKQELAQDNQHKEGHASVKEFIADKRLWLLAGIYFCVVMGQYAI-TFWLPTLIRNSGISDNWhIG 287
Cdd:cd17324 173 --------------LLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALyTYLAPFLTDVPGFSSSA-II 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 288 LLTSLPYMCAIVVMILAGRSGDHFQERRwhLIIPMCAGAIALTFATLFASNLTLSLICLCIAASGVLTASSLFWMLPTNF 367
Cdd:cd17324 238 GLLLLFGVAGVVGSPLAGRLADRGGRRA--LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446304029 368 LGGvsAAAGIAAVNSFA-NLAGFCSPYLIGWVTTNTGSNAIGMFLITAVLI 417
Cdd:cd17324 316 APE--ARGLASSLYLAAyNLGGALGAALGGLVLDHGGWAGVGWVGAALLLL 364
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
29-420 |
3.42e-15 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 76.89 E-value: 3.42e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 29 LMLCYFCAYLDRVNVGFAKLQMMS----------------------DLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKV 86
Cdd:cd17318 4 LFLGFAVVYAMRVNLSVAIVAMVNstathdnnntstdkdtlpveapEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 87 GARRwiariMITWGILSGCF------AFVQTEWQFYT-LRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPI 159
Cdd:cd17318 84 GAKR-----VLGYSILITALltlltpLAARGGYGALIvLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 160 SGMIGGPLSGLIMDrmsgvhgWFGWQWMFVIEAIPTVLVGLLvlavlkdsvqeanWLTqdeknLVKQelaqdnqhkegha 239
Cdd:cd17318 159 GTVIAMPLSGFLCE-------SLGWPSIFYIFGGLGLLWCLL-------------WFF-----LVLP------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 240 svkefiadkrLWLLAGIYFCVVMGQYAITFWLPTLIRNS---GISDNwhiGLLTSLPYMCAIVVMILAGRSGDHFQERRW 316
Cdd:cd17318 201 ----------VWAIVVAHFGHNWGFYTLLTELPTYMSDVlhfNIKSN---GFLSSLPYLAMWICSIVGGYLADWLRSRGI 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 317 H-------------LIIPMCAgAIALTFATLFASnLTLSLICLCIAASGVLTASSLfwmlpTNFLGGVSAAAGI--AAVN 381
Cdd:cd17318 268 LstttvrklftsigFLGPGVF-LIALGYLGSNAT-LAVVFLTLSVGLSGACYSGFL-----VNHLDLAPNYAGTlmGITN 340
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 446304029 382 SFANLAGFCSPYLIGWVTTNTGSNA---IGMFLITAVLIFGA 420
Cdd:cd17318 341 TAATIAGIISPLIVGAIVKNDQTIGqwrIVFFISAAIYILGA 382
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
48-423 |
5.47e-13 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 69.97 E-value: 5.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 48 LQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRW--IARIMITWGILsGCFAFVQTEWQFYTLRFLLGVA 125
Cdd:cd17341 23 PVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVfiASLLLLLIPLL-ALALAVSSYWGLLVLGFLLGFA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 126 EAGLAPGlLLYLTYWFPsyRRARMTVLWFIAipISGMIGGPLSGLIMDRMSG----VHGWFGWQWMFVIEAIPTVLVGLL 201
Cdd:cd17341 102 GANFASG-QPWASFWFP--KEKIGGAAGGIA--GAGNMGVAVSQLLAPLIAGaivfDGGFVGWRNAFFVPGILLAIAAVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 202 VLAVLKDsvqeanwlTQDEKNLVKQELAQdnqhkeghasVKEFIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGIS 281
Cdd:cd17341 177 VLLFGDD--------LPTGKASALEFLKV----------QLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 282 DNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERR--WHLIIPMCAGAIALTFA-TLFASNLTLSLICLCIAASGVLTAS- 357
Cdd:cd17341 239 PLVTAGILAALFPLAGALARPAGGWLSDRFGGRRrlWWLFIVMTIGAALLSLSlPTSGTNLVLFLALFVALGLGAGAGNg 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446304029 358 SLFWMLPTNFLGGVSAAAGIaaVNSFANLAGFCSPYLIGWVTTNTGSNAIGmFLITAVLIFGASLV 423
Cdd:cd17341 319 SVFRMVPFIFRRELGAVTGL--VGAIGGLGGFFLPLLFGSSALMTGSGVGA-FSLFGVLAVACTLL 381
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
38-398 |
3.17e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 67.77 E-value: 3.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 38 LDRVNVGFAklqmmsdlqFSEAVYGLGAGIFFIGYFLcevpsnivlHKVGARRWIARIMITWGILSGCFAFVQTEWQFYT 117
Cdd:TIGR00895 49 LDPVQLGFL---------FSAGLIGMAFGALFFGPLA---------DRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 118 LRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDRmsgvhgwFGWQWMFVIEAIPTVL 197
Cdd:TIGR00895 111 LRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPV-------FGWRSLFYVGGIAPLL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 198 VGLLVLAVLKDSV------------QEANWLTQDEKNLVKQELAQDNQHKEGHASVKEFIADKR-------LWLLagiYF 258
Cdd:TIGR00895 184 LLLLLMRFLPESIdflvskrpetvrRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKtaritvlLWLL---YF 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 259 CVVMGQYAITFWLPTLIRNSGISDNWHIGLLTSLpYMCAIVVMILAGRSGDHFqeRRWHLIIPMCAGAIALTFATLFASN 338
Cdd:TIGR00895 261 MLLVGVYFLTNWLPKLMVELGFSLSLAATGGALF-NFGGVIGSIIFGWLADRL--GPRVTALLLLLGAVFAVLVGSTLFS 337
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 339 LTLSLICLCIAASGVLTASSLFWMLPTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWV 398
Cdd:TIGR00895 338 PTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
31-417 |
4.95e-12 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 67.27 E-value: 4.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 31 LCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQ 110
Cdd:cd17345 10 IGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 111 ----TEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMdrmsgvhGWFG--- 183
Cdd:cd17345 90 satsSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGL-------AIFGdgw 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 184 WQWMFVIEAIPTVLVGLLVLAVLKDSVQEANWLTQDE-KNLVKQELAQDNQHKEghASVKEFIA-----DKRLWLLAGIY 257
Cdd:cd17345 163 WRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEyKGDYPEEADGEEEEQE--LSAWEIFVkyvlkNKLLWYIAIAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 258 FCVVMGQYAITFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDH-FQERRwhliIPMCAGAIALTFATLF- 335
Cdd:cd17345 241 VFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKlFKGRR----APTGIIFMILVIVALIv 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 336 ---ASNLTLSLICLCIAAS---------GVLTASslfwMLPTNFLGgvsAAAGIAAV------NSFANLagfcspyLIGW 397
Cdd:cd17345 317 ywlAPNVLVDLIALIALGFliygpvmliGLQALE----LVPKKAAG---TAAGLTGLfgylggSVLATA-------LIGI 382
|
410 420
....*....|....*....|
gi 446304029 398 VTTNTGSNAIGMFLITAVLI 417
Cdd:cd17345 383 IVDHFGWNGGFIVLLASCIL 402
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
29-428 |
2.87e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 64.53 E-value: 2.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 29 LMLCYFCAYLDRVNV---GFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGC 105
Cdd:cd17365 1 LALCFLIIVLDGFDLavmGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 106 FAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDRmsgvhgwFGWQ 185
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPA-------FGWR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 186 WMFVIEAIPTVLVGLlvlavlkdsvqeanwltqdeknLVKQELaqdnqhkeghasvkefiadkrlwLLAGIYFCVVMGQY 265
Cdd:cd17365 154 SVFLLGGVPPLILLP----------------------LLRGTL-----------------------LLWVTFFMGLLLVY 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 266 AITFWLPTLIRNSGISDNwHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWHLIIPMCAGAIALTFATLFASnltLSLIC 345
Cdd:cd17365 189 LLNSWLPKLMVEAGYSLS-QALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPAS---LVLLY 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 346 LCIAASGVLT--ASSLFWMLPTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGS--NAIGMFLITAVLIFGAS 421
Cdd:cd17365 265 VLVFLAGACVngAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGpeSVFLALAIPAALGALAV 344
|
....*..
gi 446304029 422 LVLRVPA 428
Cdd:cd17365 345 LLLRLRR 351
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
24-194 |
1.03e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 62.14 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 24 RLMPFLMLCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILS 103
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 104 GCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDrmsgvhgWFG 183
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA-------ALG 166
|
170
....*....|.
gi 446304029 184 WQWMFVIEAIP 194
Cdd:COG0477 167 WRWIFLINAPL 177
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
29-398 |
3.17e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 61.48 E-value: 3.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 29 LMLCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNiVLHKVGARRWIARIMIT-WGILSGCFA 107
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFG-YLGDRYNRKWILAVGILiWSAATLLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 108 FVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLImdrmsgVHGWFGWQWM 187
Cdd:cd17328 83 FAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLV------AQATGGWRWA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 188 FVIEAIPTVLVGLLVLAVLKDSvqeanwltqdEKNLVKQELAQDNQHKEGHASVKEFIADKRLWLLAGIYFCVVMGQYAI 267
Cdd:cd17328 157 FRVTGVLGVLLAILLLLFVREP----------PRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGAL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 268 TFWLPTLIRNSGISDNW---HIGL-LTSLPYMCAIVVMILAGRSGDHFQER--RWHLIIPMCA--GAIALTFATLFASNL 339
Cdd:cd17328 227 AFWAPTFFLRAFGVGDLssaDVGLiFGAITCIAGVLGVLLGGILADRLRRKtpRADPLVCAVGllAAAPFLFLALVLALS 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446304029 340 TLSLICLCIAAS--------GVLTASSLFWMLPTNFlggVSAAAGIAAVNSfaNLAGFCSPYLIGWV 398
Cdd:cd17328 307 NLLLAWVLLFLGefllslnwAPVFAILLYVVIPTRR---STASAIQILLSH--LLGDAGSPYLIGLI 368
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
85-425 |
2.01e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 58.85 E-value: 2.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 85 KVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAGLAP-GLLLYLTYWFPSYRRARMTVLWfIAIPISGMI 163
Cdd:cd17371 60 RFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAaGAALMAEYVPARHRGKALGYVQ-SGWAVGWLL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 164 GGPLSGLIMDRMSGVHgwfGWQWMFVIEAIPtvlvgLLVLAVLKDSVQE-ANWltqdeknlvkQELAQDNQHKEGHASVK 242
Cdd:cd17371 139 ATLLAALLFPLLPPEI---AWRVLFLLGALP-----ALLVLFIRRFVKEpPQW----------QAARAARRHFADRPSLR 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 243 EFIADK--RLWLLAGIYFCVV-MGQYAITFWLPTLIRNS-GISDNWHIGLLTSLpYMCAIVVMILAGRSGDHFQeRRWHL 318
Cdd:cd17371 201 ELFSPPllRTTLLASLLATGAlGGYYGITTWLPSYLTGErGLSFEGSAGYLVVT-ILGGFLGYLAGGFLADRIG-RRNNF 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 319 IIPMCAGAIALTFATLFASNLTLSLICLCI---AASGVLtaSSLFWMLPTNFLGGVSaAAGIAAVNSFANLAGFCSPYLI 395
Cdd:cd17371 279 ALFALGSAISILLYFFLPLSPTLILILGFPlgfFASGPF--SGMGAYLTELFPTAVR-ATAQGFCYNVGRIIGALFPFLV 355
|
330 340 350
....*....|....*....|....*....|.
gi 446304029 396 GWVTTNTG-SNAIGMFLITAVLIFGASLVLR 425
Cdd:cd17371 356 GFLATSGSlGTAIAVFAAVYYIAGLVLALLL 386
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
119-424 |
2.12e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 58.74 E-value: 2.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 119 RFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDrmsgvhgwFGWQWMFVIEAIPTVLV 198
Cdd:cd17473 95 RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE--------IGWRAPFLVYLLALPVL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 199 GllvlavlkdsvqeANWLTQDEKNLVKQElaqdnqHKEGHASVKEFIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNS 278
Cdd:cd17473 167 I-------------LVLLFLPEPARKSKS------AASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQER 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 279 GISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWHLIIPMCAGAIALTFATlfASNLTLSLICLCIA--ASGVLTA 356
Cdd:cd17473 228 GGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL--ASGLWVVLLGAILAglGFGLLLP 305
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446304029 357 SSLFWMlpTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAiGMFLITAVLIFGASLVL 424
Cdd:cd17473 306 TLNSWA--MSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLS-GAFLILGVLALVLAIVL 370
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
90-426 |
6.13e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 57.67 E-value: 6.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 90 RWIARIMITWGIL-----SGCFAFVQTEWQFYTLRFLLGVAEAG-LAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMI 163
Cdd:cd17355 64 RFGPRRVMLLGLLllaagLVLLALATSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 164 GGPLSGLIMDrmsgvhgWFGWQWMFVIEAIPTVLVGLLVLAVLKDSVQEAnwltqdeknlvKQELAQDNQHKEGHASVKE 243
Cdd:cd17355 144 FLPLGAALIE-------AFGWRTALLVLALLALLVLVPVLLLLRRRPADL-----------ALRAYDDASPASPGSTLKE 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 244 FIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDNwHIGLLTSLPYMCAIVVMILAGRSGDHFqERRWHLIIPMC 323
Cdd:cd17355 206 ALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPA-AAAVALALIGLFNIVGRLLSGWLGDRY-SPRRLLAASYA 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 324 AGAIALT-FATLFASNLTLSLICLCIAASGVLTaSSLFWMLPTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNT 402
Cdd:cd17355 284 LRALGLAlLLLLPFPPLALLLFAALFGLGWGAT-VPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRT 362
|
330 340
....*....|....*....|....
gi 446304029 403 GSNAIGMFLITAVLIFGASLVLRV 426
Cdd:cd17355 363 GSYTAAWALAVALGLIAALLVLPI 386
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
146-425 |
6.71e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.60 E-value: 6.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 146 RARMTVLWFIAIPISGMIGGPLSGLIMDRMSGVHGWfGWQWMFVIEAIPTVLVGLLVLAVLKDSVQEANwltqdeknlvk 225
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAAL-GYRLTALIFAVLGLLAFLLTFFGTKERPVPEE----------- 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 226 qelaqdnQHKEGHASVKEFIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNS-GISDNWhIGLLTSLPYMCAIVVMILA 304
Cdd:COG2211 213 -------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAAL-VGLLLALYFLAALLGAPLW 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 305 GRSGDHFQERRWHLIIPMCAGAIALTFATLFASNLTLSLICLCIAASGVLTASSLFWML------PTNFLGGVSAAAGIA 378
Cdd:COG2211 285 PRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMladvvdYDEWKTGRRREGLYF 364
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446304029 379 AVNSFAN-LAGFCSPYLIGWVTTNTGSNA-------------IGMFLITAVLIFGASLVLR 425
Cdd:COG2211 365 GIFTFAIkLGQALAGALAGLLLALFGYVAgaaqspsaltgirLLFFLLPAVLLLLAALLLL 425
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
50-424 |
1.49e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.09 E-value: 1.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 50 MMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAGL 129
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 130 APGLLLYLTYWFPSYRRARMTVLWFIAIPIsgmiGGPLSGLIMDRMSGVhgwFGWQWMFVIEAIPTVLVGLLVLAVLKDS 209
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPL----GGALAAALLPPLALH---YGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 210 vQEANWLTQDEKNLvkqelaqdnqhkegHASVKEFIADKRLWLLAGIYFCVVMGQYAI-TFWLPTLIRNSGISDNwHIGL 288
Cdd:cd17475 175 -PAASAATESASTL--------------LRSLKEVLRNRDVWLIAIAGALLVAPQFALlTFLLLFLHDHLGLSVV-AAGA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 289 LTSLPYMCAIVVMILAGRSGDHFQERRWHLIIPMCAGAIALTFATL-FASNLTLSLICLCIAASGVLTAS---SLFWMLP 364
Cdd:cd17475 239 LLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLsLLSPGTPLWLLVLLLILLGLFAIgwnGLYLTLV 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 365 TNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAIGMFLITAVLIFGASLVL 424
Cdd:cd17475 319 AESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
52-418 |
4.92e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.52 E-value: 4.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 52 SDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAGLAP 131
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 132 GLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDrmsgvhgWFGWQWMFVIEAIPTVLVGLLVLavlkdsvq 211
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ-------HLGFAVLFIVAAVLALLALLLVF-------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 212 eanwltqdeknLVKQELAQDNQHKEGHASVKEFIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDnwhIGLLTS 291
Cdd:cd17489 169 -----------LVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN---AGLFFT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 292 LPYMCAIVVMILAGRSGDHFQeRRWHLIIPMCAGAIALtFATLFASNLTLSLIclciaaSGVLTA---SSLFWMLPTNFL 368
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRKG-PKTVIIPGLLLLALGL-LLLSFAGSPWMLLL------AAVLYGlgfGLLFPALQALAV 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446304029 369 GGVSAA---AGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAigMFLITAVLIF 418
Cdd:cd17489 307 DLVPPHrrgAANGTFFIFFDLGIGLGGLLLGLVAELFGYRA--MFLLAAVVVL 357
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
23-193 |
8.22e-08 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 53.95 E-value: 8.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 23 FRLMPFLMLCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGIL 102
Cdd:cd17488 2 IHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 103 SGCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDrmsgvhgWF 182
Cdd:cd17488 82 NILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAAL-------TY 154
|
170
....*....|.
gi 446304029 183 GWQWMFVIEAI 193
Cdd:cd17488 155 GWRAGMYVPGI 165
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
57-401 |
2.69e-07 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 52.44 E-value: 2.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 57 SEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIM---ITWGILSGCFAFVQTEWQFYtLRFLLGVAEAGLAPGL 133
Cdd:TIGR00894 74 SGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMflsSVISIVIPWAAGGGIALVVF-CRVIQGLAQGSVSPAT 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 134 LLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDRmsgvhgWFGWQWMFVIEAIPTVLVGLLVLAVLKDSVQEA 213
Cdd:TIGR00894 153 HKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCES------WGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIH 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 214 NWLTQDEKNLVKQELAQDNQHKEGHASVKEFIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDNWHIGLLTSLP 293
Cdd:TIGR00894 227 PCISKFEKKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLP 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 294 YMCAIVVMILAGRSGDHFQERRWHLIIPMCA--------GAIALTFATLFASN---LTLSLICLCIAASGVLTASSLfwm 362
Cdd:TIGR00894 307 YLFAWLCSIFAGYLADFLKSSKTLSLTAARKifngigglGPGIFAYALPYLSAafyLTIIILTLANAVSSGPLAGVL--- 383
|
330 340 350
....*....|....*....|....*....|....*....
gi 446304029 363 lpTNFLGGVSAAAGIaaVNSFANLAGFCSPYLIGWVTTN 401
Cdd:TIGR00894 384 --INSLDLAPRFLGF--IKGITGLPGFIGGLIASTLAGN 418
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
49-424 |
7.95e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.03 E-value: 7.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 49 QMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAG 128
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 129 LAPGLLLYLTYWFPSYRRARMTVLWFIAIPIsGMIGGPLSGlimdrmsGVHGWFGWQWMFVIEAIPTVLVGLLVLAVLKD 208
Cdd:cd17474 104 LGPLALTLIGDLFEGGERAKAMGLYEAALGL-GIAVGPLLG-------GLLAAISWRYPFFLLAALIPVAFLAILFLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 209 SVQEANWLTQdeknlvkqelaqdnqhkEGHASVKEFIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDNWHIGL 288
Cdd:cd17474 176 PKEKAKSSSA-----------------TKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 289 LTSLPYMCAIVVMILAGRSGDHFQERRWHLIIPMCAGAIALtFATLFASNLTLSLICLCIAASGVLTASSLFWMLPTNFL 368
Cdd:cd17474 239 LFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSL-LLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 446304029 369 GGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAigMFLITAVLIFGASLVL 424
Cdd:cd17474 318 PEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA--PFLVGAAIALAAAVLL 371
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
107-390 |
9.82e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.63 E-value: 9.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 107 AFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDrmsgvhgWFGWQW 186
Cdd:cd17321 79 ALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE-------LFGWRW 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 187 MFVIEAIptvlvgllvlavlkdsvqeanwltqdeknlvkqelaqdnqhkeghASVKEFIADKRLWLLAGIYFCVVMGQYA 266
Cdd:cd17321 152 IFLINVP---------------------------------------------IGLVALLLARTFSGAVLAAFLLGAALGG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 267 ITFWLPTLIRNSGISDNWHIGLLTsLPYMCAIVVM-ILAGRSGDHFQERRwhliiPMCAGAIALTFATLFASNLTLSLIC 345
Cdd:cd17321 187 LLFLLPLYLQGVLGYSPLQAGLAL-LPLALAMLVAaPLAGRLADRFGPRL-----VLVAGLLLTAVGLLLLALLGADSSV 260
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 446304029 346 LCIAASGVLT--ASSLFWMLPTNF-LGGVSAA-AGIA-AVNSFANLAGFC 390
Cdd:cd17321 261 WLLLPGLVLLglGLGLFATPLTNAaLSSVPKEkAGAAsGILNTARQLGGA 310
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
1-270 |
1.21e-06 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 50.48 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 1 MDTVFSSEVDTTvrksaYRKIAFRLMPFLMLCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSN 80
Cdd:PRK11663 5 PLITDKHEIDAR-----YRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 81 IVLHKVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAipis 160
Cdd:PRK11663 80 IVSDRSNARYFMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTA---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 161 GMIGGPLSGLIMDRMSgVHgwFGWQWMFVIEAIPTVLVGLLVLAVLKDSVQE------ANWlTQDEKNLVKQELAQDNQH 234
Cdd:PRK11663 156 HNVGGALIPLVVGAIA-LH--YGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAmglpsvGEW-RHDALELAQQQEGAGLSR 231
|
250 260 270
....*....|....*....|....*....|....*.
gi 446304029 235 KEghASVKEFIADKRLWLLAGIYFCVVMGQYAITFW 270
Cdd:PRK11663 232 KE--ILTKYVLLNPYIWLLSFSYVLVYVVRAAINDW 265
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
250-425 |
3.12e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.82 E-value: 3.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 250 LWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDNWhIGLLTSLPYMCAIVVMILAGRSGDHFQERRwhLIIPMCAGAIAL 329
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQ-AGLVVTAYLLGAALGAPLAGRLADRFGRRR--VLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 330 TFATLFASNLTLSLICLCIAASGVLTASSLFWMLPTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAIgm 409
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV-- 166
|
170
....*....|....*.
gi 446304029 410 FLITAVLIFGASLVLR 425
Cdd:COG2814 167 FLVNAVLALLALLLLL 182
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
50-193 |
4.58e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 48.34 E-value: 4.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 50 MMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAGL 129
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446304029 130 APGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDRmsgvhgwFGWQWMFVIEAI 193
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA-------FGFATPFLAAAA 362
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
56-422 |
4.34e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.24 E-value: 4.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 56 FSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLL 135
Cdd:cd17477 28 VSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSES 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 136 YLTYWFPSYRRARMTVLWFIAIpISGMIGGPLSGLIMdrmsGVHGWFGWQWMFVIEAIPTVLVGLLVLavlkdsvqeanw 215
Cdd:cd17477 108 WLNALATNENRGRVLGLYSTVL-GLGFALGPLLLALV----GTAGALPFLIAAVLLLLALVPLLLTRR------------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 216 ltqdeknlvkqelaqDNQHKEGHASVKEFIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDNWhIGLLTSLPYM 295
Cdd:cd17477 171 ---------------AAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQ-AALLLAAFVL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 296 CAIVVMILAGRSGDHFQeRRWHLIIPMCAGAIALTFATLFASNLTLSLICLCIAASGVLTASSLFWMLPTNFLGGVSAAA 375
Cdd:cd17477 235 GGLLLQWPLGWLADRFD-RRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVA 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446304029 376 GIAAVNSFANLAGFCSPYLIGWVTTNTGSNAIGMFLITAVLIFGASL 422
Cdd:cd17477 314 ANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
60-418 |
4.27e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 42.25 E-value: 4.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 60 VYGLGAGIFFIGYFLCEVPSNIVLHKVGaRRWIARIMITWGILSGCFAFVQTEWQFYTL----RFLLGVAeAGLAPGLL- 134
Cdd:cd17357 50 LWSLIVSIFFIGGAIGSFISAFLANRFG-RKNGLLISNALLVVSSLLMFLSKSAKSPELlifgRFLVGIA-CGLSTGFVp 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 135 LYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSgliMDRMSGvhGWFGWQWMFVIEAIPTVLVGLLVL---------AV 205
Cdd:cd17357 128 MYLQEISPSELRGALGSLTQIGVTLGILLGQVFG---LPSVLG--TETLWPYLLFFPGIPALLQLAALPffpespkflLI 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 206 LKDSVQEA--------NWLT--QDEKNLVKQELAQDNQHKEGhaSVKEFIADKRLWLLAGIYFCVVMGQ-----YAITFW 270
Cdd:cd17357 203 SKGDEEEAekslkflrGIEDdvDQELEEIKKESEQMGDQKQV--SLMQLLRDPSLRLPLLLVLVVSASQqfsgiNAIFFY 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 271 LPTLIRNSGISD------NWHIGLLTSLPYMCAIVVMILAGrsgdhfqeRRWHLIIP--MCAGAIALTFATLFASNLTLS 342
Cdd:cd17357 281 STFIFENAGFSPqlaewaNLGIGIVNVLSTIVGPFLIEKVG--------RRPLLLISlsVCAVALLLMSVFLFLSEQNSW 352
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446304029 343 LICLCIAASGVLTASSLFWMLPTNFLGG--VSAAAGIAAVNSFANLAGFCSPYLIGwVTTNTGSNAIGMFlitAVLIF 418
Cdd:cd17357 353 MSYGCIVAIFLFIFFFAIGLGPIPWFIGaeLFPQAPRSAAQSLGSSVNWTSNFIVG-MAFPPLQSIGGGF---VFIIF 426
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
52-427 |
6.21e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.82 E-value: 6.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 52 SDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRW--IARIMITwGILSGCFAFVQTEWQFYTLRFLLGVAEAGL 129
Cdd:cd17490 24 ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLfiIIGLLFT-VLASLIMILFPSPWGLLIARFLSGIAAATW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 130 APGLLLYLTYwFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDRmsgvhgwFGWQWMFVIEAIPTVLVGLLVlavlkds 209
Cdd:cd17490 103 VSFTVLYASY-FPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEH-------FGMRAPFLLAALAGVLGFILS------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 210 vqeanwLTQDEKNLVKQELAQDNQhkeghaSVKEFIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDNWHIGLL 289
Cdd:cd17490 168 ------LFIKEERREKKPVLTELK------ELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 290 TSLPYMCAIVVMILAGRSGDHFQERRWHLIIPMCAGAIAlTFATLFASNLTlsLICLCIAASGvLTASSLFWMLPTNFLG 369
Cdd:cd17490 236 SIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAY-CFLIPFAPNLT--LLYLLQALNG-FGTGILFPLLMSLSIE 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446304029 370 GVSAAAGIAAVNSFANLAG---FCSPYLIGWVTTNTGSNaiGMFLITAVLIFGASLVLRVP 427
Cdd:cd17490 312 GVPAEQRSTAMGFFQAIYAlgmFLGPVLVGIISEAFGLQ--TGFFVIGVIALLAAILSLAY 370
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
240-431 |
8.36e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 41.83 E-value: 8.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 240 SVKEFIADKRLWL-LAGIYFCVVMGQYAITFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGR-SGDHFQERrwh 317
Cdd:PRK08633 224 NLKLLRSDRVLWLaIIGLSYFWFISQLAQANFPAYAKEVLGLDNTFQVQYLLAASAIGIGIGSLLAGRlSGRHIELG--- 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 318 lIIPMcaGAIALTFATLFASNL-TLSLICLCIAASGVltASSLF---------WMLPTNFLGGVSAAagiaavNSFANLA 387
Cdd:PRK08633 301 -LVPL--GALGLALSLFLLPTApSLASVLVLFFLFGF--SAGLFivplnaliqFRAPEKELGKVLAA------NNFLQNV 369
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 446304029 388 GFCSPYLIGWVTTNTGSNAIGMFLITAVLIFGASL--VLRVPAKLV 431
Cdd:PRK08633 370 GMLLFLALTTLFSGLGLSPAGLFYLIALVTLIGTLytLLLLPDSLL 415
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
49-427 |
9.02e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 41.14 E-value: 9.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 49 QMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEA- 127
Cdd:cd06180 24 LMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAf 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 128 GLAPGLLLYLtYWFPSYRRARMtvlwfIAIPISGM-IGGPLSGLIMDRM--SGVHGWFGWQWMFVIEAIPTVLVGLLVLA 204
Cdd:cd06180 104 VFVFGSNLVL-HHATAAGRGHL-----IGLLFAGVgLGIALSGLLVPAGlgGGLSWRAGWLALALLSAVLLLLSFLLLRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 205 VLKDSVQEAnwltqdeknlvkqelaqdnqhkeghASVKEFIADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGISdNW 284
Cdd:cd06180 178 GPSAPTEAS-------------------------AAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAG-SL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 285 HIGLLTSLPYMCAIVVMILAGRSGDHFQERRWHLII-PMCAGAIALTFATLFASNLTLSliclCIAASGVLTASSLFWML 363
Cdd:cd06180 232 LAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANlLVQAVGVLLPLLSPGPAGLVLS----AVLFGGTFMAITALVMA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446304029 364 PTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAIGMFLITAVLIFGASLVLRVP 427
Cdd:cd06180 308 LARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALLVL 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
253-429 |
9.03e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 9.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 253 LAGIYFCVVMGQYAITFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWhLIIPMCAGAIALTFA 332
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV-LLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 333 tLFASNLTLSLICLCIAASGVLTASSLFWMLPTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNTGSNAIGMFLI 412
Cdd:pfam07690 80 -LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170
....*....|....*..
gi 446304029 413 TAVLIFGASLVLRVPAK 429
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPP 175
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
82-193 |
1.33e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.71 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 82 VLHKVGARRWIARIMITWGILSGCF----AFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAI 157
Cdd:cd17391 259 RLGKLGDRIGHHRILLGALLASALLyipqAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQ 338
|
90 100 110
....*....|....*....|....*....|....*.
gi 446304029 158 PIsGMIGGPLSGlimdrmSGVHGWFGWQWMFVIEAI 193
Cdd:cd17391 339 YL-GNVAGPLLG------SAIAAHFGYRAVFVVTAL 367
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
67-423 |
2.65e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.61 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 67 IFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRR 146
Cdd:cd17333 39 SQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 147 ARMTVLWFiAIPISGMIGGPLSGLIMDRMsgvhgwFGWQWMFVIEAIPTVLVGLLVLAVLKDSVQEANwltqdeknlvkQ 226
Cdd:cd17333 119 TRLNVLHG-FFGLGALIGPLIATSLLTSE------LSWSWAYLIIGLIYLLLAILILLTLFPELPSAR-----------N 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 227 ELAQDNQHKEGHASVKEFIAdkrlWLLAGIY-FCVVMGQYAITFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAG 305
Cdd:cd17333 181 PQQSVGAFSASASRLLRNPS----IILGALAlFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 306 RSGDHFQERRWHLIIpmCAGAIALTFATLFASNLTLSLICLciaASGVLTASSLFWMLPTNFLG--GVSAAAGIAAVNSF 383
Cdd:cd17333 257 PISRRIKPHTLLVLS--GSGALLGLLILLLAPTLVVGLVAT---ALLGLFMAALFPTILSLGISnlPYAKGKGTSVLLAA 331
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 446304029 384 ANLAGFCSPYLIGWVTTNTGSN-AIGMFLITAVLIFGASLV 423
Cdd:cd17333 332 GSIGGAIIPFIMGFIAEAVGIQtAMLLITILYAIIFVLALL 372
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
52-350 |
4.66e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.82 E-value: 4.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 52 SDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFV-QTEWQFYTLRFLLGVAEAGLA 130
Cdd:TIGR00886 30 DDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGIAGGSFA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 131 PGLLLyLTYWFPsyRRARMTVLWFIAipISGMIGGPLSGLIM---------DRMSGVHGWFGWQWMFVIEAIPTVLVGLL 201
Cdd:TIGR00886 110 SCMPW-ISFFFP--KKIQGTALGLAA--GWGNMGGGVAQFVMppiigslifGGGQPAHLAWGWAFVIVPAGILLLPALLI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 202 VLAVLKDSVqeanwltqdeknlvkqelaqdNQHKEGHASVKEFIA---DKRLWLLAGIYFCVVMGQYAITFWLPTLIRNS 278
Cdd:TIGR00886 185 FFVGADTPP---------------------GKPATGKLSFKEALKvfgNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQ 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446304029 279 GISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERR--WHLIIPMCAGAIALTFATLFASNLT---LSLICLCIAA 350
Cdd:TIGR00886 244 FGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARklLMNFLGVAMGAFLVVLGLVSDGSLAafiVLFVALFFFA 320
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
45-426 |
5.85e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 5.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 45 FAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGILSGCFAFV-----QTEWQFYTLR 119
Cdd:cd06173 20 VALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 120 FLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMdrmsgvhGWFGWQWMFVIEAIPTVLVG 199
Cdd:cd06173 100 FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV-------ALLGPGGAFAINALSFLLSA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 200 LLVLAVLKDSVQEANwltqDEKNLVKQELaqdnqhKEGHASVKEFIADKRLWLLAGIYFCVVMGQYAItfwLPTLIRNSG 279
Cdd:cd06173 173 LLLLFIRRPPPAAPG----ESSSLLLRDL------REGLRYLRRSPLLRLLLLALALFALLGGALTVL---LPLLAKEVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 280 ISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFqeRRWHLIIPMCAGAIALTFATLFASNLTLSLICL-----CIAASGVL 354
Cdd:cd06173 240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRR--RRGRLLLIGALLLGLALLVLGLSPSLWLLLAALfllglAGGLFNVP 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446304029 355 TASSLFWMLPTNFLGGVsaaagIAAVNSFANLAGFCSPYLIGWVTTNTGSNAIgmFLITAVLIFGASLVLRV 426
Cdd:cd06173 318 LNTLLQLRVPDELRGRV-----FSVYNALNSGAMPLGALLAGLLADALGLSAV--FLLAGALLLLAALLLLL 382
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
85-425 |
7.22e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.36 E-value: 7.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 85 KVGARRWIARIMITWGILSGCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIG 164
Cdd:cd17329 61 RFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 165 GPLSGLIMDrmsgvhgwFGWQWMFVIEAIPTVLVGLLvlavlkdsvqeaNWLTQDEKNLVKQELAQDNQHKeghaSVKEF 244
Cdd:cd17329 141 PLLGGLLLL--------YSFRLLFLAAAVLFLLAALV------------LLFLLPETRPKRRAAEKTEILR----GYKIV 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 245 IADKRLWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQERRWhLIIPMCA 324
Cdd:cd17329 197 LRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKI-LMIGILL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 325 GAIALtFATLFASNLTLSLICLCIAASGVLTASSLFWMLPTNFLGGVSAAAGIAAVNSFANLAGFCSPYLIGWVTTNtgS 404
Cdd:cd17329 276 FAIGF-AVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDL--L 352
|
330 340
....*....|....*....|.
gi 446304029 405 NAIGMFLITAVLIFGASLVLR 425
Cdd:cd17329 353 GPGLPWLILAALGLIAAALLL 373
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
65-139 |
7.97e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 38.36 E-value: 7.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 65 AGIFFIGYFLCEVP------SNIVLHKVGARRWIARIMITWGILSGCF----AFVQTEWQFYTLRFLLGVAEAGLAPGLL 134
Cdd:PRK09874 254 SNIAFISGMIASVPgvaallSAPRLGKLGDRIGPEKILITALIFSVLLlipmSFVQTPLQLGILRFLLGAADGALLPAVQ 333
|
....*
gi 446304029 135 LYLTY 139
Cdd:PRK09874 334 TLLVY 338
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
250-420 |
8.37e-03 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 38.22 E-value: 8.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 250 LWLLAGIYFCVVMGQYAITFWLPTLIRNSGISDNWHIGLLTSLPYMCAIVVMILAGRSGDHFQE---------RRWHLII 320
Cdd:cd17381 210 LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREkqnfstvcvRKIFTLI 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 321 PMCAGAIALTFATLFASNLTLSLICLCIAAS-GVLTASSLFwmlpTNFLGGVSAAAGI--AAVNSFANLAGFCSPYLIGW 397
Cdd:cd17381 290 GMIGPAVFLLAAGFTGCNYSLAVAFLTISSTlGGFSASGFN----INHLDIAPSYAGIllGITNTFATIPGMVGPVIAKS 365
|
170 180
....*....|....*....|....*
gi 446304029 398 VT-TNTGSNAIGMFLITAVL-IFGA 420
Cdd:cd17381 366 LThNNTVEEWQTVFYISAAInVFGA 390
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
24-424 |
9.59e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 38.08 E-value: 9.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 24 RLMPF--LMLCYFCAYLDRVNVGFAKLQMMSDLQFSEAVYGLGAGIFFIGYFLCEVPSNIVLHKVGARRWIARIMITWGI 101
Cdd:cd17343 1 QLTIFasMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 102 LSGCFAFVQTEWQFYTLRFLLGVAEAGLAPGLLLYLTYWFPSYRRARMTVLWFIAIPISGMIGGPLSGLIMDRmsgvhgw 181
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALS------- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 182 FGWQWMFVIEAIPTVLVGLLVLAVLKDSVQEANwltqdeKNLVKQELAQDNQHKE--GHASVKEFIADKRLWLLAGIYFC 259
Cdd:cd17343 154 YGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVG------LNNIEEEESKGKKKKSprGESTLKELLLSPFLWLLSLGYLV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 260 VVMGQYAITFWLPTLIrnsgISDNWHIGLLTSLpYMCAIVV-----MILAGRSGDHFQERRWHLIipmcAGAIALTFATL 334
Cdd:cd17343 228 VFGVKTAVTDWGQLFL----IQDKGQSALTGSS-FMSSLEVggfvgSIAAGYLSDWAVAKHGSSS----RGNPRMPLALV 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446304029 335 FASNLTLSLICLCIAasgVLTASSLFWMLPTNFLGGVSAAA-----GIAAVNS---------------FANLAGFCSPYL 394
Cdd:cd17343 299 FMAGLTVSLHLFRVH---ITSDSSELFILLLGFLIGFSLYGpiaifGVIANESapshlcgtshaivalAANVGGVLAGLP 375
|
410 420 430
....*....|....*....|....*....|
gi 446304029 395 IGWVTTNTGSNAIGMFLITAVLIFGASLVL 424
Cdd:cd17343 376 FSYIAKHYDWRTAFLLLEILCAITVVILFL 405
|
|
| |
