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Conserved domains on  [gi|446310214|ref|WP_000388069|]
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low molecular weight protein-tyrosine-phosphatase [Acinetobacter baumannii]

Protein Classification

low molecular weight protein-tyrosine-phosphatase( domain architecture ID 11611401)

low molecular weight protein-tyrosine-phosphatase is a small soluble single-domain enzyme that catalyzes the dephosphorylation of O-phosphotyrosine groups in phosphoproteins

EC:  3.1.3.48
Gene Ontology:  GO:0004725|GO:0006470
PubMed:  12678841|12882518|27676368
SCOP:  4000436

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 5-158 4.53e-66

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


:

Pssm-ID: 319971  Cd Length: 147  Bit Score: 198.05  E-value: 4.53e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214   5 YKVLCVCLGNICRSPTAEVVFKHYCDQH-QLNIIVDSAGTSNYHPNKAPDQRSQLHAKKRGYDLSSLRARQLSTQDFLDF 83
Cdd:cd16343    1 KKILFVCLGNICRSPMAEAVLRHLLPKAgGDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSGHRARQLTAEDFDEF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446310214  84 DLILAMDHQNFDDIHDLlqraifqfGSHQIRAKVALMSEHDPQyPQQALPDPYYGGDEGFERVLDQCESSALAWI 158
Cdd:cd16343   81 DLILAMDESNLRDLRRL--------APAEARGKVFLLGDFDPE-GGKDVPDPYYGGREGFEEVYDLIERACEGLL 146
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 5-158 4.53e-66

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 198.05  E-value: 4.53e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214   5 YKVLCVCLGNICRSPTAEVVFKHYCDQH-QLNIIVDSAGTSNYHPNKAPDQRSQLHAKKRGYDLSSLRARQLSTQDFLDF 83
Cdd:cd16343    1 KKILFVCLGNICRSPMAEAVLRHLLPKAgGDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSGHRARQLTAEDFDEF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446310214  84 DLILAMDHQNFDDIHDLlqraifqfGSHQIRAKVALMSEHDPQyPQQALPDPYYGGDEGFERVLDQCESSALAWI 158
Cdd:cd16343   81 DLILAMDESNLRDLRRL--------APAEARGKVFLLGDFDPE-GGKDVPDPYYGGREGFEEVYDLIERACEGLL 146
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
5-163 7.28e-47

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 149.16  E-value: 7.28e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214   5 YKVLCVCLGNICRSPTAEVVFKHYCDQHqlnIIVDSAGTsnyHPNKAPDQRSQLHAKKRGYDLSSLRARQLSTQDFLDFD 84
Cdd:COG0394    4 KRVLFVCTGNICRSPMAEALLRHLAGGR---VEVDSAGT---EPGGPVDPRAVAVLAERGIDLSGHRSRQLDEEDLPEFD 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446310214  85 LILAMDHQNFDDIHDLLqraifqfgshqiRAKVALMSEHDpqypqqaLPDPYYGGDEGFERVLDQCESSALAWINILKK 163
Cdd:COG0394   78 LVITMCDSAAEELCPLF------------PGAAKLLLHWD-------VPDPYYGGLEAFREVRDEIERRIEALLAKLRR 137
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
7-157 1.32e-42

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 138.66  E-value: 1.32e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214    7 VLCVCLGNICRSPTAEVVFKHYCDQHQLNII--VDSAGTSNYhPNKAPDQRSQLHAKKRGYDLSSLRARQLSTQDFLDFD 84
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLGDKveVDSAGTGAW-PGNPADPRAVEVLKEHGIDLSGHYARQLSTEDFASFD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446310214   85 LILAMDHQNfddIHDLLQRAIFQFgshqiRAKVALMSEHDPQYpqqALPDPYYGGDEGFERVLDQCESSALAW 157
Cdd:pfam01451  80 LILAMDSEH---KRDLCPLAPERY-----RAKVMLLGEYGEQL---DIPDPYYGSIDAFEEVRDLIERRCRQL 141
LMWPc smart00226
Low molecular weight phosphatase family;
7-159 1.67e-33

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 115.26  E-value: 1.67e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214     7 VLCVCLGNICRSPTAEVVFKHYCdqhQLNIIVDSAGTSNYHPNKaPDQRSQLHAKKRGYDLSSLrARQLSTQDFLDFDLI 86
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYV---GDRVKIDSAGTGAWVGGG-ADPRAVKVLKEHGIDLSHH-ASQLTSSDFKNADLV 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446310214    87 LAMDHQNFDDIHDLLQRAifqfgshqiRAKVALMSEHdpqypqQALPDPYYGGDEGFERVLDQCESSALAWIN 159
Cdd:smart00226  76 LAMDGSHLRNICRLKPPS---------RAKVELFGHY------VDVDDPYYGGIDGFERVYDELENALQEFLK 133
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
6-164 1.62e-22

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 87.66  E-value: 1.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214   6 KVLCVCLGNICRSPTAEVVFKHYcdqhQLNIIVDSAGTSNYhPNKAPDQRSQLHAKKRGYDLSSLRARQLSTQDFLDFDL 85
Cdd:PRK10126   4 NILVVCVGNICRSPTAERLLQRY----HPELKVESAGLGAL-VGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDL 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446310214  86 ILAMDHQNFDDIHDLlqraifqfgSHQIRAKVALMSEHDpqyPQQALPDPYYGGDEGFERVLDQCESSALAWINILKKQ 164
Cdd:PRK10126  79 ILTMEKRHIERLCEM---------APEMRGKVMLFGHWD---NECEIPDPYRKSREAFEAVYTLLERSARQWAQALNAE 145
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 5-158 4.53e-66

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 198.05  E-value: 4.53e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214   5 YKVLCVCLGNICRSPTAEVVFKHYCDQH-QLNIIVDSAGTSNYHPNKAPDQRSQLHAKKRGYDLSSLRARQLSTQDFLDF 83
Cdd:cd16343    1 KKILFVCLGNICRSPMAEAVLRHLLPKAgGDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSGHRARQLTAEDFDEF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446310214  84 DLILAMDHQNFDDIHDLlqraifqfGSHQIRAKVALMSEHDPQyPQQALPDPYYGGDEGFERVLDQCESSALAWI 158
Cdd:cd16343   81 DLILAMDESNLRDLRRL--------APAEARGKVFLLGDFDPE-GGKDVPDPYYGGREGFEEVYDLIERACEGLL 146
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
5-163 7.28e-47

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 149.16  E-value: 7.28e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214   5 YKVLCVCLGNICRSPTAEVVFKHYCDQHqlnIIVDSAGTsnyHPNKAPDQRSQLHAKKRGYDLSSLRARQLSTQDFLDFD 84
Cdd:COG0394    4 KRVLFVCTGNICRSPMAEALLRHLAGGR---VEVDSAGT---EPGGPVDPRAVAVLAERGIDLSGHRSRQLDEEDLPEFD 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446310214  85 LILAMDHQNFDDIHDLLqraifqfgshqiRAKVALMSEHDpqypqqaLPDPYYGGDEGFERVLDQCESSALAWINILKK 163
Cdd:COG0394   78 LVITMCDSAAEELCPLF------------PGAAKLLLHWD-------VPDPYYGGLEAFREVRDEIERRIEALLAKLRR 137
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
7-157 1.32e-42

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 138.66  E-value: 1.32e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214    7 VLCVCLGNICRSPTAEVVFKHYCDQHQLNII--VDSAGTSNYhPNKAPDQRSQLHAKKRGYDLSSLRARQLSTQDFLDFD 84
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLGDKveVDSAGTGAW-PGNPADPRAVEVLKEHGIDLSGHYARQLSTEDFASFD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446310214   85 LILAMDHQNfddIHDLLQRAIFQFgshqiRAKVALMSEHDPQYpqqALPDPYYGGDEGFERVLDQCESSALAW 157
Cdd:pfam01451  80 LILAMDSEH---KRDLCPLAPERY-----RAKVMLLGEYGEQL---DIPDPYYGSIDAFEEVRDLIERRCRQL 141
LMWPc smart00226
Low molecular weight phosphatase family;
7-159 1.67e-33

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 115.26  E-value: 1.67e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214     7 VLCVCLGNICRSPTAEVVFKHYCdqhQLNIIVDSAGTSNYHPNKaPDQRSQLHAKKRGYDLSSLrARQLSTQDFLDFDLI 86
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYV---GDRVKIDSAGTGAWVGGG-ADPRAVKVLKEHGIDLSHH-ASQLTSSDFKNADLV 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446310214    87 LAMDHQNFDDIHDLLQRAifqfgshqiRAKVALMSEHdpqypqQALPDPYYGGDEGFERVLDQCESSALAWIN 159
Cdd:smart00226  76 LAMDGSHLRNICRLKPPS---------RAKVELFGHY------VDVDDPYYGGIDGFERVYDELENALQEFLK 133
LMWP cd00115
Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group ...
 7-157 1.84e-23

Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.


Pssm-ID: 319970  Cd Length: 137  Bit Score: 89.47  E-value: 1.84e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214   7 VLCVCLGNICRSPTAEVVFKHYCDQhqlNIIVDSAGTSNYHpNKAPDQRSQLHAKKRGYDLSSlRARQLSTQDFLDFDLI 86
Cdd:cd00115    2 ILFICTGNICRSPMAEAIFKQLLGD---EWKVDSAGTGAHH-GEGADPRAVRVLKEVGIDISH-RSDQIKSEHLDNYDLV 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446310214  87 LAMDHQNFDDIhdlLQRaifqfgshQIRAKVALMSEHDpQYPQQALPDPYYGGDEGFERVLDQCESSALAW 157
Cdd:cd00115   77 LVMDGSNLDKI---PRI--------FPEARGKTWLPHV-KLEHGEIDDPYRGDIEDFRRVRDELENASKRF 135
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
6-164 1.62e-22

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 87.66  E-value: 1.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214   6 KVLCVCLGNICRSPTAEVVFKHYcdqhQLNIIVDSAGTSNYhPNKAPDQRSQLHAKKRGYDLSSLRARQLSTQDFLDFDL 85
Cdd:PRK10126   4 NILVVCVGNICRSPTAERLLQRY----HPELKVESAGLGAL-VGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDL 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446310214  86 ILAMDHQNFDDIHDLlqraifqfgSHQIRAKVALMSEHDpqyPQQALPDPYYGGDEGFERVLDQCESSALAWINILKKQ 164
Cdd:PRK10126  79 ILTMEKRHIERLCEM---------APEMRGKVMLFGHWD---NECEIPDPYRKSREAFEAVYTLLERSARQWAQALNAE 145
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 5-89 6.58e-18

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 75.16  E-value: 6.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214   5 YKVLCVCLGNICRSPTAEVVFKHYCDqhQLNIIVDSAGTSNYHPNKAPDQRSQLhAKKRGYDLSSLRARQLSTQDFLDFD 84
Cdd:cd16344    1 MKILFVCTGNTCRSPMAEAILKKLLE--ELDVEVKSAGIFAVDGSPASPNAVEV-LKEKGIDLSGHRSQQLTEELLEWAD 77


                 ....*
gi 446310214  85 LILAM 89
Cdd:cd16344   78 LILTM 82
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 7-157 6.91e-15

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 67.74  E-value: 6.91e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214   7 VLCVCLGNICRSPTAEVVFKhycdQHQLNIIVDSAGTSNY--HPnkaPDQRSQLHAKKRGYDLSSLRARQLSTQDFLDFD 84
Cdd:PRK11391   5 ILVVCTGNICRSPIGERLLR----KRLPGVKVKSAGVHGLvkHP---ADATAADVAANHGVSLEGHAGRKLTAEMARNYD 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446310214  85 LILAMDHQNFDDIHDLlqraifqfgSHQIRAKVALMSEhdpQYPQQALPDPYYGGDEGFERVLDQCESSALAW 157
Cdd:PRK11391  78 LILAMESEHIAQVTAI---------APEVRGKTMLFGQ---WLEQKEIPDPYRKSQDAFEHVYGMLERASQEW 138
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 6-89 1.47e-06

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 45.13  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310214   6 KVLCVCLGNICRSPTAEVVFKHYCDQHqlnIIVDSAGTsnyHPnkapdqrSQLHA------KKRGYDLSSLRARqlSTQD 79
Cdd:cd16345    1 KVLFLCTGNSARSQMAEALLRHLGGDR---FEAYSAGS---EP-------AGVNPlaievmKEIGIDISGQRSK--SLDE 65

                         90
                 ....*....|..
gi 446310214  80 FLD--FDLILAM 89
Cdd:cd16345   66 FLGqeFDYVITV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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