|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
11-433 |
4.82e-116 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 346.80 E-value: 4.82e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 11 PIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERA 90
Cdd:cd13143 1 PIGKLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 91 RSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGL 170
Cdd:cd13143 81 NRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 171 VVTAVLNIVFDYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTK--FHFEWDTVKQIMIIGFPSFTAES 248
Cdd:cd13143 161 LIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLlrFKLSLKIIKEILALGFPSFLMQL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 249 TVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVA 328
Cdd:cd13143 241 SSSVVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 329 IIVGLFFGKYIIGLFdVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFIIPLLWIMPK 408
Cdd:cd13143 321 FLILLLFPEQIVSLF-TDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLILPR 399
|
410 420
....*....|....*....|....*
gi 446310525 409 LFGINGIWLVMPVAEVLTAIIVFTM 433
Cdd:cd13143 400 LFGLDGIWLAFPLAEILTLLLALIL 424
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
7-433 |
1.49e-88 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 276.25 E-value: 1.49e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 7 LREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENK 86
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGR-LGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 87 IERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLA 166
Cdd:COG0534 80 REEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 167 MAGLVVTAVLNIVFDYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILK--WTKFHFEWDTVKQIMIIGFPSF 244
Cdd:COG0534 160 MIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRlrLRDLRPDRKILKRILRIGLPAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 245 TAESTVAIVTIGFNIAFVQYaGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVL 324
Cdd:COG0534 240 LQQLAESLGFLVLNALVARL-GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 325 GGVAIIVGLFFGKYIIGLFdVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFIIPLLW 404
Cdd:COG0534 319 GLLLALLLFLFPEPIIGLF-TDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAY 397
|
410 420 430
....*....|....*....|....*....|
gi 446310525 405 IMPKL-FGINGIWLVMPVAEVLTAIIVFTM 433
Cdd:COG0534 398 LLAFLgLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
12-433 |
4.27e-73 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 236.81 E-value: 4.27e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 12 IKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERAR 91
Cdd:PRK09575 10 IYRTFWRYTIPSIAAMLVNGLYQIVDGIFIGHYVGAEGLAGINMAWPVIGIILGIGLMVGMGTGSLLSIKRGEGDLEKAK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 92 SIFTQSMTVaVIIVGVLAAICLWRI-EDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGL 170
Cdd:PRK09575 90 RILTTGLLL-LLLLGPIVSVILFLFaDDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESPNLATGLM 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 171 VVTAVLNIVFDYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWT--KFHFEWDTVKQIMIIGFPSFTAES 248
Cdd:PRK09575 169 VIGALINIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFFSSRANIRLTlkELRFNWSLAPKIVLLGSSSFFMYL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 249 TVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVA 328
Cdd:PRK09575 249 YGSFVVALHNRLFMEYGSALTVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVLAGIAW 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 329 IIVGLFFGKYIIGLFDVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSrGLLFIIPLLWIMPK 408
Cdd:PRK09575 329 VLLLNLFPETMIALFNSGDSELIAETIVGIRLHLFAMFLDGFLVLASAYFMAVNQGGKALFISIG-NMLIQLPFLFILPK 407
|
410 420
....*....|....*....|....*
gi 446310525 409 LFGINGIWLVMPVAEVLTAIIVFTM 433
Cdd:PRK09575 408 WLGVDGVWLAMPLSNIALSLVVAPM 432
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-429 |
7.34e-59 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 199.00 E-value: 7.34e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 11 PIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERA 90
Cdd:cd13144 5 PVLRLLLTMSIPAMISMLFQALYNIVDSIFVAR-LGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 91 RSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGL 170
Cdd:cd13144 84 NKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 171 VVTAVLNIVFDYIFIFIF----KWGVTGAASATILSAAIGFLVLLTHFLRKSSI--LKWTKFHFEWDTVKQIMIIGFPSF 244
Cdd:cd13144 164 LIGAIINIILDPILIFGLfgfpAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDvqPDLRLFRPSLRIIKEIYAVGLPSI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 245 TAESTVAIVTIGFNIAFVQYaGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVL 324
Cdd:cd13144 244 IMQAISSVMVFGLNKILAGF-GPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 325 GGVAIIVGLFFGKYIIGLFDvQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFIIPLLW 404
Cdd:cd13144 323 MLAGGLLFQLFPDQLLGLFN-ASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLAW 401
|
410 420
....*....|....*....|....*
gi 446310525 405 IMPKLFGINGIWLVMPVAEVLTAII 429
Cdd:cd13144 402 LLAKMFGLNGVWWSFPIAEIVSFLL 426
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
12-431 |
2.28e-58 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 197.68 E-value: 2.28e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 12 IKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERAR 91
Cdd:cd13138 1 ILKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 92 SIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLtFGMIYV-LENILSTFIRNDGNPNLAMAGL 170
Cdd:cd13138 81 KAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICF-LGIPFIfGYNAYSAILRGLGDSKTPLYFV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 171 VVTAVLNIVFDYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTK--FHFEWDTVKQIMIIGFPSFTAES 248
Cdd:cd13138 160 IIACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLkdFRFDKEILKEILKIGLPSALQQS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 249 TVAIVTIGFNiAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVA 328
Cdd:cd13138 240 LVSISFLIIN-SIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLII 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 329 IIVGLFFGKYIIGLFdVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFIIPLLWIMPK 408
Cdd:cd13138 319 ILLVFFFAPQLLGLF-TSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSR 397
|
410 420
....*....|....*....|....*
gi 446310525 409 LF--GINGIWLVMPVAEVLTAIIVF 431
Cdd:cd13138 398 LTglGLFGIWLAMPISNILSAIICI 422
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
21-432 |
1.98e-53 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 185.05 E-value: 1.98e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 21 IPAVLGMVLMSVNIVIDAVMISrGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTV 100
Cdd:cd13147 16 IPMIIAMLLQTLYNLVDAIWVA-GLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVHSILL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 101 AVIIVGVLAAICLWRIEDLAYLFGANEViLPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF 180
Cdd:cd13147 95 GLIISIILTIVLLPFLEPILVLMGAGEV-LDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSILNIIL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 181 DYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRKSS---ILKWTKFHFEWDTVKQIMIIGFPSFTAESTVAIVTIGF 257
Cdd:cd13147 174 DPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKDtyvSLSLKNFKFDKKIVKDILKVGIPASLEQLIMSVLMIIL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 258 NIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVAIIVGLFFGK 337
Cdd:cd13147 254 NLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIAILIFIFAP 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 338 YIIGLFDV--QSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFIIPLLWI--MPKLFGIN 413
Cdd:cd13147 334 QIAYLFTYseESAHLAPEIVAFLRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITILRELIFQVLFAYLfaIVLGLGLF 413
|
410
....*....|....*....
gi 446310525 414 GIWLVMPVAEVLTAIIVFT 432
Cdd:cd13147 414 GVWWGIVLGNAIGSIVGYL 432
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
21-431 |
3.54e-48 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 170.77 E-value: 3.54e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 21 IPAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTV 100
Cdd:cd13137 8 WPVILENLLQTLVGLVDVFMVGR-LGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQSLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 101 AVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF 180
Cdd:cd13137 87 ALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 181 DYIFIF----IFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILK--WTKFHFEWDTVKQIMIIGFPSFTAESTVAIVT 254
Cdd:cd13137 167 DYVLIFglwgFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKisFKGFRLDRKIIKKLLRIGLPAGLEQLLRSLGF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 255 IGFnIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVAIIVGLF 334
Cdd:cd13137 247 LVL-LAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLGLLLFI 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 335 FGKYIIGLFdVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFIIPLLWIMPKLF--GI 412
Cdd:cd13137 326 FAPPLASLF-TPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGFVLglGL 404
|
410
....*....|....*....
gi 446310525 413 NGIWLVMPVAEVLTAIIVF 431
Cdd:cd13137 405 TGIWLAMFVDTIVRAILLL 423
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
21-431 |
3.04e-46 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 165.19 E-value: 3.04e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 21 IPAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTV 100
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGR-LLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 101 AVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF 180
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 181 DYIFIFIF---KWGVTGAASATILSAAIGFLVLLTHFLRKSSIL--KWTKFHFEWDTVKQIMIIGFPSFTAESTVAIVTI 255
Cdd:cd12082 161 DPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKKILkfKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 256 GFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVAIIVGLFF 335
Cdd:cd12082 241 IIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 336 GKYIIGLFdVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFIIPLLWIMPKL-FGING 414
Cdd:cd12082 321 PEPILSLF-TNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLgLGLYG 399
|
410
....*....|....*..
gi 446310525 415 IWLVMPVAEVLTAIIVF 431
Cdd:cd12082 400 IWLALVISLILAALVLL 416
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-431 |
6.72e-35 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 134.65 E-value: 6.72e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 7 LREKPIKSLFISYLIPAVLGMVLMSVNIVID---AVMISrgvgANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALG 83
Cdd:cd13145 2 LTKGPIPKLIRKLAIPASVGFFFNTMFNVVDtffAGKIS----TEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 84 ENKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNP 163
Cdd:cd13145 78 AGDRRKARRYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 164 NLAMAGLVVTAVLNIVFDYIFIF----IFKWGVTGAASATILSAAIGFLVLLTHfLRKSSIL---KWTKFHFEWDTVKQI 236
Cdd:cd13145 158 KSYRNFLIIGFFLNIILDPLFIFggggIPAMGVSGIALATIISQFIGMFYLLYK-VRKSGIIsgcRLRDFIPRLDVYKEI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 237 MIIGFPsftaeSTVAIVTIGFNIAFVQYA----GEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLRE 312
Cdd:cd13145 237 LKQGFP-----ASLNMMTIGLGIFVITYFvgqfGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRE 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 313 GLQFAVKIAVVLGGVAIIVGLFFGKYIIGLFDvQSPELLEltlTGI------SLFFIQYVFLGyniVYGEYFQSVRQTTK 386
Cdd:cd13145 312 TYKKALKYGFVIMVVATVFLLFFAEPLMSLFT-NDPAVIA---IGAgylridALIFYAYVVLF---ISVSVLQGLKRPIF 384
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 446310525 387 SVLIIMSRGLLFIIPLLWIMPKLFG--INGIWLVMPVAEVLTAIIVF 431
Cdd:cd13145 385 ALWIGLYRQLVGPALVFWLLVNVLGlgVTGIWWGIFTIVWSAAIIAL 431
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
21-431 |
1.44e-34 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 133.78 E-value: 1.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 21 IPAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTV 100
Cdd:cd13134 10 WPIFIELLLQMLLGTIDTFMLSR-YSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 101 AVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF 180
Cdd:cd13134 89 NLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIVG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 181 DYIFIFIF----KWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTK--FHFEWDTVKQIMIIGFPSFtAESTVAIVT 254
Cdd:cd13134 169 NYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKdlRPFPKKLLKKILKIGLPSA-GEELSYNLS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 255 IGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVAIIVGLF 334
Cdd:cd13134 248 QTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVALLLAL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 335 FGKYIIGLFdVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFIIPLLWIM--PKLFGI 412
Cdd:cd13134 328 FREPILGLF-TDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYLLgiVLGLGL 406
|
410
....*....|....*....
gi 446310525 413 NGIWLVMPVAEVLTAIIVF 431
Cdd:cd13134 407 LGVWIAFAADEWVRGIIML 425
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-431 |
1.74e-34 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 133.47 E-value: 1.74e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 5 EKLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGE 84
Cdd:cd13142 2 ENILEGSILRTLLKLAWPIIVSNLLQVAYNLADTFWLGR-LGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 85 NKIERARSIFTQSMTVAVIIVGVLAAICLWRIED-LAYLFGANEVILPYALEYLHVL---LTFGMIYvleNILSTFIRND 160
Cdd:cd13142 81 GDYDKANKVAGQTFSFVIILSLILAVLGYILSRPlLLLLIGAPEEVYPLALAYLRIIflgLPFMFIF---FVFNSLLRGI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 161 GNPNLAMAGLVVTAVLNIVFDYIFIFIF----KWGVTGAASATILSAAIGFLVLLTHFLRKSSILK--WTKFHFEWDTVK 234
Cdd:cd13142 158 GDTKTPMKIMFGSVLLNVILDPLLIFGIgpfpGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKisLRDLKPDWEWLK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 235 QIMIIGFPSFTAESTVAivtIGFNI--AFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLRE 312
Cdd:cd13142 238 KIFRIGLPSSIEQSARA---LGFTVmtALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 313 GLQFAVKIAVVLGGVAIIVGLFFGKYIIGLFdVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIM 392
Cdd:cd13142 315 IVKKAALLIFLILVIGGVLAFLFAEPIVRVF-INDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISI 393
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 446310525 393 SRGLLFIIPLLWIM--PKLFGINGIWLVMPVAEVLTAIIVF 431
Cdd:cd13142 394 LRLWVIRIPLAYLLayVLGLGVTGIWIAMAISNIVAALIAL 434
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
6-435 |
1.76e-34 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 133.58 E-value: 1.76e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 6 KLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGEN 85
Cdd:cd13149 1 KLTEGSIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGK-LGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 86 KIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNL 165
Cdd:cd13149 80 DRNKAKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 166 AMAGLVVTAVLNIVFDYIFIF----IFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTKFHFE--WDTVKQIMII 239
Cdd:cd13149 160 PSLVMLGAALVNVILDPILIFgfgpIPGMGIAGAAIATVISRALGLGAALYFLHYHHRLIDFSEPSLKalFRSWKDILSI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 240 GFPSftAESTVAI-VTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAV 318
Cdd:cd13149 240 GIPA--ALSNILTpLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 319 KIAVVLGGVAIIVGLFFGKYIIGLFDvQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLF 398
Cdd:cd13149 318 KFSLIYGAILGIVLALFAGWLASLFS-AEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLL 396
|
410 420 430
....*....|....*....|....*....|....*...
gi 446310525 399 IIPLLWIMPKLFGINGIWLVMPVAEVLTAII-VFTMNR 435
Cdd:cd13149 397 YIPLAYVGSHLLGFAGVFIGALAGNLIAGILaYFIAKK 434
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-429 |
2.55e-33 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 130.42 E-value: 2.55e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 11 PIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERA 90
Cdd:cd13139 11 SLNRAIFLLAIPMVLEMVMESLFAVVDLYFVSR-LGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 91 RSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGL 170
Cdd:cd13139 90 GFAAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 171 VVTAVLNIVFDYIFIF----IFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTKFHF--EWDTVKQIMIIGFPSf 244
Cdd:cd13139 170 WLANGLNIILDPLFIFglgpIPAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRHLklDWAIIKKIIKIAVGG- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 245 TAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVL 324
Cdd:cd13139 249 ILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVF 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 325 GGVAIIVGLFFGKYIIGLFdVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFIIPLLW 404
Cdd:cd13139 329 LGIVSLVFFLFAEPLVSFF-TTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAY 407
|
410 420
....*....|....*....|....*..
gi 446310525 405 IMPKLF--GINGIWLVMPVAEVLTAII 429
Cdd:cd13139 408 LLARHLnlGPKGVFIAIPIAETVLAIA 434
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
22-353 |
3.46e-33 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 128.13 E-value: 3.46e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 22 PAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTVA 101
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGH-LGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 102 VIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVFD 181
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 182 YIFIFIF--KWGVTGAASATILSAAIGFLVLLTHFLRKSSI-LKWTKFHFE-WDTVKQIMIIGFPSFTAESTVaIVTIGF 257
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIgLKWEGLLKPdWEVLKRLLKLGLPIAFRVILE-SLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 258 NIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVAIIVGLFFGK 337
Cdd:TIGR00797 239 LALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFRE 318
|
330
....*....|....*.
gi 446310525 338 YIIGLFDvQSPELLEL 353
Cdd:TIGR00797 319 FIARLFT-NDPEVLEL 333
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
21-429 |
1.39e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 125.33 E-value: 1.39e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 21 IPAVLGMVLMSVNIVIDAVMISR----GVGANGLAGVnVAIPAFSIFFSISlwigMGGATLYSIALGENKIERARSIFTQ 96
Cdd:cd13133 12 LPLVLSMLSQTVMGFTDRAFLGRlsevALAASGPAGV-LYFAILMLFFGLS----SGVQVFVAQYNGAGRYSRIGRVLWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 97 SMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVL 176
Cdd:cd13133 87 GLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 177 NIVFDYIFIF----IFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILK---WTKFHFEWDTVKQIMIIGFPSfTAEST 249
Cdd:cd13133 167 NIVLDYALIFgklgFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRfglRRAWRFDRELLRRILRLGLPS-GLQFF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 250 VAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVAI 329
Cdd:cd13133 246 LDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLLG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 330 IVGLFFGKYIIGLF-DVQSPELLELTLTGISLFFIQYVFL-GYNIVygeYFQSVRQT--TKSVLIIM--SRGLLFIIPLL 403
Cdd:cd13133 326 ILFLLFPELLLSIFtPGADFALIAELAVPLLRFVAAYILFdALALV---FAGALRGAgdTRFVMLAEliVAWLYLLPPAY 402
|
410 420
....*....|....*....|....*.
gi 446310525 404 WIMPKLFGINGIWLVMPVAEVLTAII 429
Cdd:cd13133 403 LLVVLGAGLAGAWTVETVYVIVLALI 428
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-427 |
5.76e-29 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 117.89 E-value: 5.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 7 LREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANG--LAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGE 84
Cdd:cd13146 1 MFSGPISPLLIRLALPILIGQLFQLLYNITDTIWISMIDPSDPalVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 85 NKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPN 164
Cdd:cd13146 81 QRAKELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 165 LAMAGLVVTAVLNIVFDYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFL-RKSSI-LKWTKFHFEWDTVKQIMIIGFP 242
Cdd:cd13146 161 YMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLiGKSNVtIHIKLSNISSSVIVEILRVGLP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 243 SFTAESTVAIVTIGFNiAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAV 322
Cdd:cd13146 241 QMLLQLISSISFLIYN-RIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 323 VLGGVAIIVGLFFGKYIIGLFdVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFIIPL 402
Cdd:cd13146 320 VVVLVLVLGYVLVAPWLFSLF-TTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPV 398
|
410 420
....*....|....*....|....*..
gi 446310525 403 LWIMPKLF--GINGIWLVMPVAEVLTA 427
Cdd:cd13146 399 VYLLAYVFgkGITGVYFGIVSANFFTA 425
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
30-431 |
5.23e-28 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 115.31 E-value: 5.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 30 MSVNIViDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTVAVIIVGVLA 109
Cdd:cd13140 22 MAYNLT-DMFWVGR-LGSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKYARNALQLNLLLGILYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 110 AICLWRIEDLAYLFGAN-EVILPYALEYLhVLLTFGMI-YVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVFDYIFIFI 187
Cdd:cd13140 100 LLLLLFAKPLIGFFNLGdAEVISLAITYL-RIVALGLIfSFLNPVFTGIFNALGDSKTPFIINAIGLVLNIILDPLLIFG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 188 F----KWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTKF--HFEWDTVKQIMIIGFPSFTAESTVAIVTIGFNiAF 261
Cdd:cd13140 179 FgpfpALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRIlkRPDRKYIKEILKLGLPVALQSILFALISMILA-RI 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 262 VQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVAIIVGLFFGKYIIG 341
Cdd:cd13140 258 IASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFS 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 342 LFdVQSPELLELtltGIS----LFFIQyVFLGYNIVYGEYFQSVRQtTKSVLIIMSRGLLFIIPLLWI-MPKLFGINGIW 416
Cdd:cd13140 338 LF-IPDPETIAI---GVDylriLGFSQ-LFMCLEITTTGAFNGLGR-TKPPAIISIVFNGLRIPLALLlSPTGLGLNGIW 411
|
410
....*....|....*
gi 446310525 417 LVMPVAEVLTAIIVF 431
Cdd:cd13140 412 WAISISSILKGIILT 426
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-435 |
1.94e-25 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 107.79 E-value: 1.94e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 11 PIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERA 90
Cdd:cd13141 8 SIPKHIISMALPIAIGMIIQTLYFLVDLYFVGQ-LGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 91 RSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLH-----VLLTFGMIyvlenILSTFIRNDGNPNL 165
Cdd:cd13141 87 NAVFNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYwfipsLALQFILT-----VLGAALRGTGIVKP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 166 AMAGLVVTAVLNIVFDYIFIF----IFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILK--WTKFHFEWDTVKQIMII 239
Cdd:cd13141 162 FMVIQILAVLLNIILAPILITgwgtGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRldLALWRPDLPTWKRLLKI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 240 GFPSfTAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVK 319
Cdd:cd13141 242 GLPS-GGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 320 IAVVLGGVAIIVGLFFGKYIIGLFDvQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFI 399
Cdd:cd13141 321 LTTALMLVLTLLCQLVPELLVTPFS-DDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRLLTFA 399
|
410 420 430
....*....|....*....|....*....|....*..
gi 446310525 400 IPLLWIMPKL-FGINGIWLVMPVAEVLTAIIVFTMNR 435
Cdd:cd13141 400 LPVIWLSAQPdFRIEQIWYLSVATTILQAALSLLLLR 436
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
21-419 |
5.57e-24 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 103.41 E-value: 5.57e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 21 IPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTV 100
Cdd:cd13136 10 LPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIALLVRALLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 101 AVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLtFGMIYVLEN-ILSTFIRNDGNPNLAMAGLVVTAVLNIV 179
Cdd:cd13136 90 ALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRI-LGAPAVLLNyVATGWFRGLQDTRTPLILQIVGNVVNIV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 180 FDYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTKFH--FEWDTVKQIMIIGFPSFtAESTVAIVTIGF 257
Cdd:cd13136 169 LDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRrlPSKAALKRLFKLNRDIF-IRTLALLAAFLF 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 258 NIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVAIIVGLFFGK 337
Cdd:cd13136 248 FTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLFFLGGE 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 338 YIIGLFdVQSPELLELTLTGISLFFIQ-------YVFLGYNIVYGEyfqsvrqtTKSVLIIMSRGLLFIIPLLWIMPKLF 410
Cdd:cd13136 328 PIIRLF-TDDPAVLALAATYLPWLALLppigalaFVLDGIFIGATD--------TRYLRNSMLVSLAVFLPLLFLLVPLW 398
|
....*....
gi 446310525 411 GINGIWLVM 419
Cdd:cd13136 399 GNHGLWLAL 407
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
25-356 |
2.20e-20 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 92.95 E-value: 2.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 25 LGMVLMSVnivIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTVAvII 104
Cdd:cd13131 17 LAQMAMGF---VDTVMAGR-LGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVRQGLWLA-LL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 105 VGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLtFGMI-YVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVFDYI 183
Cdd:cd13131 92 LSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALA-WGIPpALLFQVLRSFLDALGRTRPAMVITLLALVLNIPLNYV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 184 FIF----IFKWGVTGAASATILSAAIGFLVLLTHFLRK---SSILKWTKFH-FEWDTVKQIMIIGFP---SFTAESTV-A 251
Cdd:cd13131 171 LIFgkfgLPALGGAGAGLATAIVYWLMFLALAFYIRRHkrfRRYRLFARFWrPDWARLKELLRLGLPiglTIFFEVSLfA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 252 IVTIgfniaFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVAIIV 331
Cdd:cd13131 251 AVAL-----LMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFAALTALL 325
|
330 340
....*....|....*....|....*
gi 446310525 332 GLFFGKYIIGLFdVQSPELLELTLT 356
Cdd:cd13131 326 LLLFPEQIAGLY-TNDPAVIALAAS 349
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
22-183 |
1.27e-18 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 82.61 E-value: 1.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 22 PAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTVA 101
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGH-LGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 102 VIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVFD 181
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 446310525 182 YI 183
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-380 |
1.35e-17 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 84.63 E-value: 1.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 3 ATEKLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWiGMGGATLYSI-- 80
Cdd:cd13148 1 RTRALLTAPILPTLLRLALPNILALLVQTLVGLAETYFVGQ-LGTDALAGVALVFPLLMLTQMMSNG-AMGGGVSSAIar 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 81 ALGENKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRND 160
Cdd:cd13148 79 ALGAGDRERAEALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 161 GNPNLAMAGLVVTAVLNIVFDYIFIF----IFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILK--WTKFHFEWDTVK 234
Cdd:cd13148 159 GNMRVPALVTLVGAVVQIPLSPGLILgwgpLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRlrLRALRLERRLFR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 235 QIMIIGFPS----FTAESTVAIVTigfniAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERL 310
Cdd:cd13148 239 DILRVGLLAalspLQTNLTVLLLT-----GLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARA 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 311 REGLQFAVKIAVVLGGVAIIVGLFFGKYIIGLFdVQSPELLELTLTGISLFFIQYVFLGYNIVYgeYFQS 380
Cdd:cd13148 314 RRIAWTGALMAAVLAGAIGLVLALFPELWLGLF-THDPAVLAAGASYLRIVGPFYGFFGLGLAL--YFAS 380
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
21-431 |
1.45e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 72.32 E-value: 1.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 21 IPAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTV 100
Cdd:cd13135 8 IPLILQNLVSQLQMLVDRAFLGR-ISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAISSIVY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 101 AVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF 180
Cdd:cd13135 87 NSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNVIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 181 DYIFIF----IFKWGVTGAASATILSAAIGFLVLLThFLRKSSILKWTKFHFE-----WDTVKQIMIIGFPSFTAESTVA 251
Cdd:cd13135 167 DYVLIFgnfgFPRLGIIGAAIATTIANVLNLIILVY-LCRKIKKLTFKLSNTKvlkanIRPYKFTIKLGLPLGGEEFLWN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 252 IVTIGFNiAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVAIIV 331
Cdd:cd13135 246 IGNLAVI-RILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIAAAIV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 332 GLFFGKYIIGLFdVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQtTKSVLI--IMSRGLLFIIPLLWIMPKL 409
Cdd:cd13135 325 FLAFPYKILSLF-TNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGD-TKWMLYtqIIGTIIVVSVALLLIFVFK 402
|
410 420
....*....|....*....|..
gi 446310525 410 FGINGIWLVMPVAEVLTAIIVF 431
Cdd:cd13135 403 LGLAGVYITLFIDEIIRAIINF 424
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
17-433 |
4.76e-13 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 70.68 E-value: 4.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 17 ISYLIPAVLGMVLMSVNIVIDAVMISRgVGANGLAGVNVAIpAFSIFFSISLWIGMGGA--TLYSIALGENKIERARSIF 94
Cdd:cd13132 6 LRLAAPLVLTSLLQYSLSVVSVVFVGH-LGKLELAAASLAS-SFANVTGFSILLGLASAldTLCGQAFGAKNYKLVGVYL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 95 tQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTA 174
Cdd:cd13132 84 -QRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLVAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 175 VLNIVFDYIFIFIFKWGVTGAASATILSAAIGFLVLLThFLRKSSILKWTKFHFEWDTVKQIMIIGFPSFTAESTVAIVT 254
Cdd:cd13132 163 LLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLL-YIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLEW 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 255 IGFNIAFV---QYAGEVGVASYAMVNSIHAMTLLLFFGVGAAlqpiASFHYGANLAERLREGLQFAVKIAVVLG---GVA 328
Cdd:cd13132 242 WAFEILVLlagLLPGTVALAAQSICLTTTSLLYMIPLGISIA----ASVRVGNELGAGNPKRAKLAAIVALILSlviGVV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 329 IIVGLFFGKYIIGLFDVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQ-SVRQTTKSVLIIMSrGLLFIIPL-LWIM 406
Cdd:cd13132 318 VAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRgCGRQKLGAYVNLVA-YYLIGLPVgLLLA 396
|
410 420
....*....|....*....|....*...
gi 446310525 407 PKL-FGINGIWLVMPVAEVLTAIIVFTM 433
Cdd:cd13132 397 FVLgLGLKGLWIGLIAGLILQAVILLLI 424
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
21-216 |
3.45e-11 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 64.79 E-value: 3.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 21 IPAVLGMVLMSV-NIVIDAVMISRGVGAngLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMT 99
Cdd:cd13138 232 LPSALQQSLVSIsFLIINSIVNSYGVVA--SAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGII 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 100 VAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMA-GLVVTAVLNI 178
Cdd:cd13138 310 ISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIiSILRLWLVRI 389
|
170 180 190
....*....|....*....|....*....|....*...
gi 446310525 179 VFDYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLR 216
Cdd:cd13138 390 PLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRK 427
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
259-405 |
5.13e-11 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 61.04 E-value: 5.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 259 IAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKIAVVLGGVAIIVGLFFGKY 338
Cdd:pfam01554 17 TLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSLPIALLVLLFSEP 96
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446310525 339 IIGLFDvQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVrQTTKSVLIIMSRGLLFIIPLLWI 405
Cdd:pfam01554 97 ILSLFG-QDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQ-GDTKPPMYINIISLLLNIPLNYL 161
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
21-217 |
1.11e-09 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 60.22 E-value: 1.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 21 IPAVLGMVLMSVNIVIDAVMISRGvGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTV 100
Cdd:cd13137 233 LPAGLEQLLRSLGFLVLLAIVASY-GTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 101 AVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAM-AGLVVTAVLNIV 179
Cdd:cd13137 312 GVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLiINLISMWLVRLP 391
|
170 180 190
....*....|....*....|....*....|....*...
gi 446310525 180 FDYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRK 217
Cdd:cd13137 392 LAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKG 429
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
21-218 |
1.87e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 59.51 E-value: 1.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 21 IPAVLGMVLMSVNIVIDAVMISrGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTV 100
Cdd:cd13142 244 LPSSIEQSARALGFTVMTALVA-GFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALL 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 101 AVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLH-VLLTFGMIYVLENILSTFiRNDGNPNLAMA-GLVVTAVLNI 178
Cdd:cd13142 323 IFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRiVAPSFPFFGLFQVINGAF-RGSGHTLTAMIiSILRLWVIRI 401
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 446310525 179 VFDYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRKS 218
Cdd:cd13142 402 PLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGT 441
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
15-431 |
1.02e-08 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 56.78 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 15 LFISYLIPAVLGMVLMsvnividaVMISRGVGANGLAGVNVAIPAFSIFFSISLwIGMGGATLYSIAlgENKIERARSIF 94
Cdd:cd13128 8 LFVGNIISKLLGFLVR--------VYLARYLGPEGFGILSLALAFVGLFSIFAD-LGLPTALVREIA--RYRKEKIREII 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 95 TQSMTVAVIIVGVLAAIclwriedlayLFGANEVILPYALEYLHVLLTFGMIYVLeNILSTFIRNDGNPNLAMAGLVVTA 174
Cdd:cd13128 77 STSLVLKLILGILALLL----------LFLFAFLIAFYDPELVLLLYILALSLPF-SALNSLFRGIFQGFEKMKYIVIAR 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 175 VLNIVFDYIFIFIF---KWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWtkFHFEWDTVKQIMIIGFPSFTaesTVA 251
Cdd:cd13128 146 IIESVLSLILALILvllGGGLIGFALAYLIASVLSAILLLYIYRKKILLPKF--FSFDLKLAKELLRFSIPLAL---SGI 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 252 IVTIGFNIAFV---QYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAErLREGLQFAVKIAVVLGGVA 328
Cdd:cd13128 221 FSLIYTRIDTImlgYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKNDKDE-LKKLLKKSFKYLFLISLPI 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 329 IIVGLFFGKYIIGLFdvQSPELLELTLTgISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSrGLLFIIPLLWIMPK 408
Cdd:cd13128 300 AIGLFLFAEPIITLL--FGEEYLPAALV-LQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLI-GALLNVILNLLLIP 375
|
410 420
....*....|....*....|...
gi 446310525 409 LFGINGIWLVMPVAEVLTAIIVF 431
Cdd:cd13128 376 KYGIIGAAIATLISEFIIFILLL 398
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
20-368 |
2.46e-07 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 52.82 E-value: 2.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 20 LIPAVLGMVLMsvnIVIDAVMISRgVGANGLA--GVNVAIPAFSIFFSISLWIGMGgaTLYSIALGENKIERARSIfTQS 97
Cdd:PRK00187 19 LIASQLAHMLM---VFTDTLMMGR-LGPEALAggGLGAASYSFVSIFCVGVIAAVG--TLVAIRHGAGDIEGATRL-AQA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 98 MTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHvLLTFGMI-YVLENILSTFIRNDGNPNLAMAGLVVTAVL 176
Cdd:PRK00187 92 GLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLH-LLPFALPgYLSFMALRGFTSALGRAGPVMVISLAGAVA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 177 NIVFDYIFIF----IFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTKF----HFEWDTVKQIMIIGFP---SFT 245
Cdd:PRK00187 171 NLLLNYALIEgwfgLPKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAYPLRkglsRPSRAALRELWRLGLPiggTYA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 246 AES---TVAIVTIGfniafvqYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGA-NLAERLREGlqfavKIA 321
Cdd:PRK00187 251 VEVglfTFAALCMG-------ALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAgRLLEARRAG-----RVG 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446310525 322 VVLGGVAIIV--GLF--FGKYIIGLF-DVQSPELLELTLTGISLFFIQYVFL 368
Cdd:PRK00187 319 IGFGAVVMLLfaGLFwlLPEAIIGLFlDRNDPAFAEIVQLAVSLLAVAAWFE 370
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
233-405 |
9.92e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 47.49 E-value: 9.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 233 VKQIMIIGFPSFTAEstVAIVTIGF-NIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLR 311
Cdd:cd13131 2 LRALLRLALPILIAQ--LAQMAMGFvDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 312 EGLQFAVKIAVVLgGVAIIVGLFFGKYIIGLFDvQSPELLELT---LTGISLFFIqyVFLGYNIVYGeYFQSVRQtTKSV 388
Cdd:cd13131 80 RAVRQGLWLALLL-SLPLMLLLWLAPPILPLMG-QEPEVAAIArgyLLALAWGIP--PALLFQVLRS-FLDALGR-TRPA 153
|
170
....*....|....*..
gi 446310525 389 LIIMSRGLLFIIPLLWI 405
Cdd:cd13131 154 MVITLLALVLNIPLNYV 170
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
1-354 |
3.01e-05 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 46.34 E-value: 3.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 1 MEATEKLREKpiKSLFISYLIPAVLGMVLMSVNIVIDAVMiSRGVGANGLAGVNVAIpafSIFFSISLWIG---MGGATL 77
Cdd:PRK01766 1 MKETQKYKSE--ARQLLALALPILLAQVAQTAMGFVDTVM-AGGVSATDLAAVAIGT---SIWLPVILFGHgllLALTPI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 78 YSIALGENKIERARSIFTQSMTVAVIIvGVLAAICLWRIED-LAYLFGANEVILPYALEYLHVLLtFGMI-YVLENILST 155
Cdd:PRK01766 75 VAQLNGAGRRERIAHQVRQGLWLALFL-SVLIMLVLYNAVPpILNMMNLEPEVADIAVGYLHALL-WGIPaYLLYQVLRS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 156 FIRNDGNPNLAMAGLVVTAVLNIVFDYIFIFiFKWGVT--GAASATILSA------AIGFLVLLTHFLRKSSILKWTKFH 227
Cdd:PRK01766 153 FIDGLGKTKPTMVIGFLGLLINIPLNYIFIY-GKFGFPelGGVGCGVATAivywvmFLAMLIYIKRARRFRDFRLFKGLY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 228 -FEWDTVKQIMIIGFP---SFTAESTV-AIVTIgfniaFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHY 302
Cdd:PRK01766 232 kPDWAVIKRLLKLGLPiglAIFFEVSLfAVVTL-----LVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFEL 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446310525 303 GANLAERLREGLQFAVKIAVVLGGVAIIVGLFFGKYIIGLFdVQSPELLELT 354
Cdd:PRK01766 307 GAGRTLDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLY-TDDPEVVALA 357
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
45-217 |
1.23e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 44.05 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 45 VGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFG 124
Cdd:cd13133 261 LGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLLGILFLLFPELLLSIFT 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 125 AN---EVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVFDYIFIFIFKWGVTGAASATIL 201
Cdd:cd13133 341 PGadfALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAYLLVVLGAGLAGAWTVETV 420
|
170
....*....|....*.
gi 446310525 202 SAAIGFLVLLTHFLRK 217
Cdd:cd13133 421 YVIVLALIFLLRFRSG 436
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
77-431 |
3.51e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 42.82 E-value: 3.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 77 LYSIALGENKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLF--GANEVILPYALEYLHVLLTFGMIYVLENILS 154
Cdd:cd13123 57 VFSEYLEKEGEEEARRFASRVLTLLLLVLLLLTLLGILFAPLLVKLLapGFSGDKFELAVALTRIMFPYLLFISLSALLG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 155 TFIRNDGNPNLAMAGLVVTAVLNIVFDYIFIFIFKWGVTGAASATILSAAIGFLVLLThFLRKSSILKWTKFHFEWDTVK 234
Cdd:cd13123 137 GILNAHGRFFAPALAPVLLNLVIIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLP-ALRRLGFRFRPRLDFRDPGVR 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 235 QIMIIGFPSFTAESTVAIVTIgFNIAFVQYAGEVGVASYAMVNSIHAMTLLLF-FGVGAALQPIASFHYGANLAERLREG 313
Cdd:cd13123 216 RVLKLMLPALLGVSVSQINLL-VDTILASFLPEGSISALYYADRLYQLPLGIFgVAIATALLPRLSRLAAAGDLDEFRRT 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 314 LQFAVKIAVVLGGVAIIVGLFFGKYII------GLFDVQSpelleLTLTGISLFF--IQYVFLGYNIVYGEYFQSvRQTT 385
Cdd:cd13123 295 LSRGLRLVLFLLLPAAVGLIVLAEPIVrllferGAFTAED-----TLMTASALAAyaLGLPAFALVKLLSRAFYA-LKDT 368
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446310525 386 KSVLIIMSRGLLFIIPLLWIMPKLFGINGIWLVMPVAEVLTAIIVF 431
Cdd:cd13123 369 KTPVKIAVIAVAVNILLNLLLIKPLGHVGLALATSLSAWVNALLLL 414
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
55-211 |
5.67e-04 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 42.17 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 55 VAIPAFSIFFSISLW-------IGMGGATLYSIALGENKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANE 127
Cdd:cd13132 258 VALAAQSICLTTTSLlymiplgISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAILLLVLRDVWAYLFTSDE 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 128 VILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNL-AMAGLVVTAVLNIVFDYIFIFIFKWGV----TGAASATILS 202
Cdd:cd13132 338 EVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLgAYVNLVAYYLIGLPVGLLLAFVLGLGLkglwIGLIAGLILQ 417
|
....*....
gi 446310525 203 AAIGFLVLL 211
Cdd:cd13132 418 AVILLLIIL 426
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
77-431 |
1.34e-03 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 40.90 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 77 LYSIALGENKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLF--GANEVILPYALEYLHVLLTFGMIYVLENILS 154
Cdd:COG0728 64 VLAEALEKEGEEEARRFASRVLTLLLLVLLVLTLLGILFAPLLVKLLapGFDPEKFALAVALTRIMFPYILFIGLSALLG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 155 TFIRNDGNPNLAMAGLVVTAVLNIVFDYIFIFIFKWGVTGAASATILSAAIGFLVLLtHFLRKSSILKWTKFHFEWDTVK 234
Cdd:COG0728 144 GVLNARGRFAAPALAPVLLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQL-PALRRLGLRLRPRFDLRDPGVR 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 235 QIMIIGFPSFTAESTVAIVTIgFNIAFVQYAGEVGVASYAMVNSIHAMTLLLF-FGVGAALQPIASFHYGANLAERLREG 313
Cdd:COG0728 223 RVLKLMLPALLGVSVSQINLL-VDTILASFLPEGSVSALYYADRLYQLPLGLFgVAIGTALLPRLSRAAAAGDLEEFRRT 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 314 LQFAVKIAVVLGGVAIIVGLFFGKYII------GLFDVQSPELLELTLtgiSLFFIQYVFLGYNIVYGEYFQSvRQTTKS 387
Cdd:COG0728 302 LSRGLRLVLLLTLPAAVGLIVLAEPIVrllferGAFTAEDTALTALAL---AAYALGLPAFALVKVLARAFYA-RQDTRT 377
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 446310525 388 VLIIMSRGLLFIIPLLWIMPKLFGINGIWLVMPVAEVLTAIIVF 431
Cdd:COG0728 378 PVRIAVIAVVVNIVLNLLLVPPLGHAGLALATSLSALVNALLLL 421
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
50-211 |
2.14e-03 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 40.11 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 50 LAGVNVAIPAFSIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTVAVIiVGVLAAICLWRIEDLA-YLFGANEV 128
Cdd:PRK10367 45 LGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQALARALVQPLLLALG-AGALIALLRTPLIDLAlHIVGGSEA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 129 ILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVFDYIFIFIFKWGVTGAASATILSAAIGFL 208
Cdd:PRK10367 124 VLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVILLVVGNILNIVLDLWLVMGLHMNVQGAALATVIAEYATLL 203
|
...
gi 446310525 209 VLL 211
Cdd:PRK10367 204 IGL 206
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
59-431 |
2.86e-03 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 39.55 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 59 AFSIFFSISLWIGMGGATLYSIAlgENKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILpyaleYLH 138
Cdd:COG2244 46 SIVALLSVLADLGLSTALVRFIA--EYREEELRRLLSTALLLRLLLSLLLALLLLLLAPFIAALLGEPELAL-----LLL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 139 VLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVFDYIFIFiFKWGVTGAasatilsaaigflvllthflrks 218
Cdd:COG2244 119 LLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLLLALLLAL-LGLGLWGL----------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 219 silkwtkfhfewdtvkqIMIIGFPSFTAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIA 298
Cdd:COG2244 175 -----------------VLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446310525 299 SFHYGANLAERLREGLQFAVKIAVVLGGVAIIVGLFFGKYIIGLFdvQSPELLELTLTgISLFFIQYVFLGYNIVYGEYF 378
Cdd:COG2244 238 SRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLL--FGPEYAEAAPV-LPILALGALFLALSGVLSNLL 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446310525 379 QSVRQtTKSVLIIMSRGLLFIIPLLWIMPKLFGINGIWLVMPVAEVLTAIIVF 431
Cdd:COG2244 315 LALGR-TRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| |
