NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446314254|ref|WP_000392109|]
View 

MULTISPECIES: type II toxin-antitoxin system PemK/MazF family toxin [Bacteria]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PemK_toxin super family cl46550
PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. ...
 55-112 1.73e-06

PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.


The actual alignment was detected with superfamily member COG2337:

Pssm-ID: 480890  Cd Length: 111  Bit Score: 45.17  E-value: 1.73e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446314254  55 YKKGTIIYVKLGVNVGREFSGNHFCMVLNNHDSNKN-PILTVVPLTSSRSK---FNVHIEED 112
Cdd:COG2337    2 PKRGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNRYsPTVIVAPITSNIRKgypFRVLLPPG 63
 
Name Accession Description Interval E-value
MazF COG2337
mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense ...
 55-112 1.73e-06

mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 441908  Cd Length: 111  Bit Score: 45.17  E-value: 1.73e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446314254  55 YKKGTIIYVKLGVNVGREFSGNHFCMVLNNHDSNKN-PILTVVPLTSSRSK---FNVHIEED 112
Cdd:COG2337    2 PKRGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNRYsPTVIVAPITSNIRKgypFRVLLPPG 63
PemK_toxin pfam02452
PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. ...
 56-105 1.81e-04

PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.


Pssm-ID: 460561  Cd Length: 108  Bit Score: 39.53  E-value: 1.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446314254   56 KKGTIIYVKLGVNVGREFSGNHFCMVLNNHDSNKNPI--LTVVPLTSSRSKF 105
Cdd:pfam02452   1 KRGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNELSTptVIVAPITSKLKGK 52
 
Name Accession Description Interval E-value
MazF COG2337
mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense ...
 55-112 1.73e-06

mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 441908  Cd Length: 111  Bit Score: 45.17  E-value: 1.73e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446314254  55 YKKGTIIYVKLGVNVGREFSGNHFCMVLNNHDSNKN-PILTVVPLTSSRSK---FNVHIEED 112
Cdd:COG2337    2 PKRGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNRYsPTVIVAPITSNIRKgypFRVLLPPG 63
PemK_toxin pfam02452
PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. ...
 56-105 1.81e-04

PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.


Pssm-ID: 460561  Cd Length: 108  Bit Score: 39.53  E-value: 1.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446314254   56 KKGTIIYVKLGVNVGREFSGNHFCMVLNNHDSNKNPI--LTVVPLTSSRSKF 105
Cdd:pfam02452   1 KRGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNELSTptVIVAPITSKLKGK 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH