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Conserved domains on  [gi|446326776|ref|WP_000404631|]
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virulence factor [Staphylococcus aureus]

Protein Classification

similar to conserved virulence factor C( domain architecture ID 12096577)

protein similar to conserved virulence factor C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Virulence_fact pfam13769
Virulence factor; This domain is found in conserved virulence factors. It is often found in ...
 111-189 3.58e-31

Virulence factor; This domain is found in conserved virulence factors. It is often found in association with pfam02985 and pfam08712.


:

Pssm-ID: 433462  Cd Length: 81  Bit Score: 113.10  E-value: 3.58e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446326776  111 FKGIPYQIKLTSADQELREQLPQTYVDHMTQAQTEHDNIVFMRKWLDLGNRYGNIEEVMDGVLEEVLATYPESQLPVLV 189
Cdd:pfam13769   3 FRGIPMQVKVTDGREEARIGLPERFEQAIDRAAMDSDNYIAERKWVEYGVRYGDLEEIAREVAEELEAAYPEERLERLV 81
HEAT COG1413
HEAT repeat [General function prediction only];
237-355 9.81e-23

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 92.38  E-value: 9.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776 237 IPLLDLALSDEKVPVRRQAIVLLGMIESKEILPYLYKGLRDKSPAVRRTAGDCISDLGYPEALPEMVLLLDDSQKIVRWR 316
Cdd:COG1413   18 VPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDEDPEVRRA 97

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446326776 317 AAMFIFDEGNAEQLPALKAHINDNAFEVKLQIEMAISRI 355
Cdd:COG1413   98 AAEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGRL 136
Nfu_N pfam08712
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 4-82 4.71e-21

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


:

Pssm-ID: 462574  Cd Length: 81  Bit Score: 85.98  E-value: 4.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776    4 LRIEPTPSPNTMKVVLSYTR-EDKLSNTYKKVEE-NQPRFINQLLSIDGITSIFHVMNFLAVDKAPKADWEVILPDIKAA 81
Cdd:pfam08712   1 IQTEPTPNPNALKFIPGKPLlPEGGTAEFKSAEEaKASPLAQKLFAIPGVKSVFIGPDFITVTKDDDVDWEDLKPEVRSV 80


                  .
gi 446326776   82 F 82
Cdd:pfam08712  81 I 81
 
Name Accession Description Interval E-value
Virulence_fact pfam13769
Virulence factor; This domain is found in conserved virulence factors. It is often found in ...
 111-189 3.58e-31

Virulence factor; This domain is found in conserved virulence factors. It is often found in association with pfam02985 and pfam08712.


Pssm-ID: 433462  Cd Length: 81  Bit Score: 113.10  E-value: 3.58e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446326776  111 FKGIPYQIKLTSADQELREQLPQTYVDHMTQAQTEHDNIVFMRKWLDLGNRYGNIEEVMDGVLEEVLATYPESQLPVLV 189
Cdd:pfam13769   3 FRGIPMQVKVTDGREEARIGLPERFEQAIDRAAMDSDNYIAERKWVEYGVRYGDLEEIAREVAEELEAAYPEERLERLV 81
HEAT COG1413
HEAT repeat [General function prediction only];
237-355 9.81e-23

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 92.38  E-value: 9.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776 237 IPLLDLALSDEKVPVRRQAIVLLGMIESKEILPYLYKGLRDKSPAVRRTAGDCISDLGYPEALPEMVLLLDDSQKIVRWR 316
Cdd:COG1413   18 VPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDEDPEVRRA 97

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446326776 317 AAMFIFDEGNAEQLPALKAHINDNAFEVKLQIEMAISRI 355
Cdd:COG1413   98 AAEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGRL 136
Nfu_N pfam08712
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 4-82 4.71e-21

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 462574  Cd Length: 81  Bit Score: 85.98  E-value: 4.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776    4 LRIEPTPSPNTMKVVLSYTR-EDKLSNTYKKVEE-NQPRFINQLLSIDGITSIFHVMNFLAVDKAPKADWEVILPDIKAA 81
Cdd:pfam08712   1 IQTEPTPNPNALKFIPGKPLlPEGGTAEFKSAEEaKASPLAQKLFAIPGVKSVFIGPDFITVTKDDDVDWEDLKPEVRSV 80


                  .
gi 446326776   82 F 82
Cdd:pfam08712  81 I 81
Nfu_N smart00932
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 5-92 1.58e-20

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 214919  Cd Length: 88  Bit Score: 84.88  E-value: 1.58e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776     5 RIEPTPSPNTMKVVLSYTREDKLSNTYKKVEE--NQPRFINQLLSIDGITSIFHVMNFLAVDKAPKADWEVILPDIKAAF 82
Cdd:smart00932   2 QTEPTPNPNTLKFLPGEFVLPGGSAEFKSADEaaEASPLAQKLFEIPGVKSVFFGPDFITVTKYPDVDWEDLKPEVLSVI 81

                           90
                   ....*....|
gi 446326776    83 SGEsqvLESG 92
Cdd:smart00932  82 MEH---FESG 88
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 238-319 4.76e-14

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 66.98  E-value: 4.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776  238 PLLDLALSDEKVPVRRQAIVLLGMIESKEILPYLYKGLRDKSPAVRRTAGDCISDLGYPEALPEMV-LLLDDSQKIVRWR 316
Cdd:pfam13646   3 ALLQALLRDPDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLeLLRDDDDDVVRAA 82


                  ...
gi 446326776  317 AAM 319
Cdd:pfam13646  83 AAE 85
 
Name Accession Description Interval E-value
Virulence_fact pfam13769
Virulence factor; This domain is found in conserved virulence factors. It is often found in ...
 111-189 3.58e-31

Virulence factor; This domain is found in conserved virulence factors. It is often found in association with pfam02985 and pfam08712.


Pssm-ID: 433462  Cd Length: 81  Bit Score: 113.10  E-value: 3.58e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446326776  111 FKGIPYQIKLTSADQELREQLPQTYVDHMTQAQTEHDNIVFMRKWLDLGNRYGNIEEVMDGVLEEVLATYPESQLPVLV 189
Cdd:pfam13769   3 FRGIPMQVKVTDGREEARIGLPERFEQAIDRAAMDSDNYIAERKWVEYGVRYGDLEEIAREVAEELEAAYPEERLERLV 81
HEAT COG1413
HEAT repeat [General function prediction only];
237-355 9.81e-23

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 92.38  E-value: 9.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776 237 IPLLDLALSDEKVPVRRQAIVLLGMIESKEILPYLYKGLRDKSPAVRRTAGDCISDLGYPEALPEMVLLLDDSQKIVRWR 316
Cdd:COG1413   18 VPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDEDPEVRRA 97

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446326776 317 AAMFIFDEGNAEQLPALKAHINDNAFEVKLQIEMAISRI 355
Cdd:COG1413   98 AAEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGRL 136
Nfu_N pfam08712
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 4-82 4.71e-21

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 462574  Cd Length: 81  Bit Score: 85.98  E-value: 4.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776    4 LRIEPTPSPNTMKVVLSYTR-EDKLSNTYKKVEE-NQPRFINQLLSIDGITSIFHVMNFLAVDKAPKADWEVILPDIKAA 81
Cdd:pfam08712   1 IQTEPTPNPNALKFIPGKPLlPEGGTAEFKSAEEaKASPLAQKLFAIPGVKSVFIGPDFITVTKDDDVDWEDLKPEVRSV 80


                  .
gi 446326776   82 F 82
Cdd:pfam08712  81 I 81
Nfu_N smart00932
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 5-92 1.58e-20

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 214919  Cd Length: 88  Bit Score: 84.88  E-value: 1.58e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776     5 RIEPTPSPNTMKVVLSYTREDKLSNTYKKVEE--NQPRFINQLLSIDGITSIFHVMNFLAVDKAPKADWEVILPDIKAAF 82
Cdd:smart00932   2 QTEPTPNPNTLKFLPGEFVLPGGSAEFKSADEaaEASPLAQKLFEIPGVKSVFFGPDFITVTKYPDVDWEDLKPEVLSVI 81

                           90
                   ....*....|
gi 446326776    83 SGEsqvLESG 92
Cdd:smart00932  82 MEH---FESG 88
HEAT COG1413
HEAT repeat [General function prediction only];
251-371 3.11e-15

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 71.97  E-value: 3.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776 251 VRRQAIVLLGMIESKEILPYLYKGLRDKSPAVRRTAGDCISDLGYPEALPEMVLLLDDSQKIVRWRAAMFIFDEGNAEQL 330
Cdd:COG1413    1 VRRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446326776 331 PALKAHINDNAFEVKLQIEMAISRIenGDEALGSVWKQMAN 371
Cdd:COG1413   81 PALIAALKDEDPEVRRAAAEALGRL--GDPAAVPALLEALK 119
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 238-319 4.76e-14

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 66.98  E-value: 4.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776  238 PLLDLALSDEKVPVRRQAIVLLGMIESKEILPYLYKGLRDKSPAVRRTAGDCISDLGYPEALPEMV-LLLDDSQKIVRWR 316
Cdd:pfam13646   3 ALLQALLRDPDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLeLLRDDDDDVVRAA 82


                  ...
gi 446326776  317 AAM 319
Cdd:pfam13646  83 AAE 85
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 268-353 4.79e-09

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 52.73  E-value: 4.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776  268 LPYLYKGL-RDKSPAVRRTAGDCISDLGYPEALPEMVLLLDDSQKIVRWRAAMFIFDEGNAEQLPALKAHI-NDNAFEVK 345
Cdd:pfam13646   1 LPALLQALlRDPDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLrDDDDDVVR 80


                  ....*...
gi 446326776  346 LQIEMAIS 353
Cdd:pfam13646  81 AAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
237-294 2.80e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.16  E-value: 2.80e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446326776 237 IPLLDLALSDEKVPVRRQAIVLLGMIESKEILPYLYKGLRDKSPAVRRTAGDCISDLG 294
Cdd:COG1413   80 VPALIAALKDEDPEVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGRLG 137
Cnd1 pfam12717
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
 251-323 2.69e-05

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 43.99  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776  251 VRRQAIVLLGMIESKEIL----PYLYKGLRDKSPAVRRTAGDCISDLGYPEA------LPEMVLLLDDSQKIVRWRAAMF 320
Cdd:pfam12717   2 IRALAIRTMGCIRFPNLVeyltEPLYRRLKDEDPYVRKTAAMCVAKLILPDMvkvkgfISELAKLLEDPNPMVVANALAA 81


                  ...
gi 446326776  321 IFD 323
Cdd:pfam12717  82 LTE 84
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 210-286 4.70e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 38.86  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776  210 LDEYHATDNWKTR---LRMLNHFPKPTFEDiPLLDLaLSDEKVPVRRQAIVLLGMIESKEILPYLYKGLRDKSPAVRRTA 286
Cdd:pfam13646   5 LQALLRDPDPEVRaaaIRALGRIGDPEAVP-ALLEL-LKDEDPAVRRAAAEALGKIGDPEALPALLELLRDDDDDVVRAA 82
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 267-293 9.19e-04

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 36.35  E-value: 9.19e-04
                          10        20
                  ....*....|....*....|....*..
gi 446326776  267 ILPYLYKGLRDKSPAVRRTAGDCISDL 293
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGEL 27
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 250-291 6.04e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 34.65  E-value: 6.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446326776  250 PVRRQAIVLLGMIES----------KEILPYLYKGLRDKSPAVRRTAGDCIS 291
Cdd:pfam13513   2 RVREAAALALGSLAEggpdllapavPELLPALLPLLNDDSDLVREAAAWALG 53
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 244-313 7.41e-03

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 38.56  E-value: 7.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446326776 244 LSDEKVPVRRQAIVLLGMIESKEILPYLYKGLR----DKSPAVRRTAGDCISDL------GYPEALPEMVL--LLDDSQK 311
Cdd:COG5096  101 LQDPNEEIRGFALRTLSLLRVKELLGNIIDPIKklltDPHAYVRKTAALAVAKLyrldkdLYHELGLIDILkeLVADSDP 180


                 ..
gi 446326776 312 IV 313
Cdd:COG5096  181 IV 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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