NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446330897|ref|WP_000408752|]
View 

amino acid ABC transporter permease, partial [Escherichia coli]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11468467)

amino acid ABC transporter permease such as Rhizobium leguminosarum general L-amino acid transport system permease protein AapQ, which is part of a binding-protein-dependent transport system for L-amino acids and affects the uptake as well as efflux of these amino acids

Gene Ontology:  GO:0043190|GO:0140359|GO:0042626|GO:0016020|GO:0006865
PubMed:  25750732|24638992|18535149|17723295
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-263 2.79e-154

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 434.96  E-value: 2.79e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897   1 FRNIPPLLQIFFWYFAVLRNLPGPRQAVSAFDLAFLSNRGLYIPSPQLGDGFIAFILAVVMAIILSVGLFRFNKTYQIKT 80
Cdd:COG4597  135 FRNIPLLLQIFFWYFAVLEALPSPRQSLSLFDGVFLNNRGLYLPAPVFEPGFGWVLAALLAAIVAAFVLRRWARRRQEAT 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  81 GQLRRTWPIAAVLIIGLPLLAQWLFGAALHWDVPALRGFNFRGGMVLIPELAALTLALSVYTSAFIAEIIRAGIQAVPYG 160
Cdd:COG4597  215 GQRFPVWWISLALLVGLPLLAFLLLGAPLSLDYPELKGFNFRGGLTLSPEFVALLLALSLYTAAFIAEIVRAGIQAVSKG 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 161 QHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIGYPDMVSLFAGTVLNQTGQAIETIAMTMSVY 240
Cdd:COG4597  295 QTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSLAVAIGYPDLVSVFAGTTLNQTGQAIEIIAITMAVY 374

                        250       260
                 ....*....|....*....|...
gi 446330897 241 LIISLTISLLMNIYNRRIAIVER 263
Cdd:COG4597  375 LTISLLISLLMNWYNRRVALVER 397
 
Name Accession Description Interval E-value
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-263 2.79e-154

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 434.96  E-value: 2.79e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897   1 FRNIPPLLQIFFWYFAVLRNLPGPRQAVSAFDLAFLSNRGLYIPSPQLGDGFIAFILAVVMAIILSVGLFRFNKTYQIKT 80
Cdd:COG4597  135 FRNIPLLLQIFFWYFAVLEALPSPRQSLSLFDGVFLNNRGLYLPAPVFEPGFGWVLAALLAAIVAAFVLRRWARRRQEAT 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  81 GQLRRTWPIAAVLIIGLPLLAQWLFGAALHWDVPALRGFNFRGGMVLIPELAALTLALSVYTSAFIAEIIRAGIQAVPYG 160
Cdd:COG4597  215 GQRFPVWWISLALLVGLPLLAFLLLGAPLSLDYPELKGFNFRGGLTLSPEFVALLLALSLYTAAFIAEIVRAGIQAVSKG 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 161 QHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIGYPDMVSLFAGTVLNQTGQAIETIAMTMSVY 240
Cdd:COG4597  295 QTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSLAVAIGYPDLVSVFAGTTLNQTGQAIEIIAITMAVY 374

                        250       260
                 ....*....|....*....|...
gi 446330897 241 LIISLTISLLMNIYNRRIAIVER 263
Cdd:COG4597  375 LTISLLISLLMNWYNRRVALVER 397
PRK15100 PRK15100
cystine ABC transporter permease;
82-263 5.18e-18

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 80.18  E-value: 5.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  82 QLRRTWP---IAAVLII---GLPLLAQwLFgaALHWDVPALrgfnfrgGMVLIPELAALtLALSVYTSAFIAEIIRAGIQ 155
Cdd:PRK15100  44 RLSPIWPvrwLARFYVSifrGTPLIAQ-LF--MIYYGLPQF-------GIELDPIPAAM-IGLSLNTAAYAAETLRAAIS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 156 AVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIGYPDmvsLFAGTVLnQTGQAIETIAM 235
Cdd:PRK15100 113 SIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPE---LFRQAQL-ITSRTLEVFTM 188

                        170       180
                 ....*....|....*....|....*...
gi 446330897 236 TMSVYLIISLTISLLMNIYNRRIAIVER 263
Cdd:PRK15100 189 YLAASLIYWIMATVLSALQNRFENQLNR 216
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 86-258 1.00e-14

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 71.04  E-value: 1.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897   86 TWPIAAVL--IIGLPLLAQWLFgaaLHWDVPALrgfnfrgGMVLiPELAALTLALSVYTSAFIAEIIRAGIQAVPYGQHE 163
Cdd:TIGR03003  50 SWPTSFVVefIRGTPLLVQLYF---LYYVLPDI-------GIRL-PALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWE 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  164 AARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIGYPDMVSLfAGTVLNQTGQAIETIAMTMSVYLII 243
Cdd:TIGR03003 119 AATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELMNQ-AKSIGNSTFRYLEPMTLVGVFFLIL 197

                         170
                  ....*....|....*
gi 446330897  244 SLTISLLMNIYNRRI 258
Cdd:TIGR03003 198 SIISVFFLRRLEARL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 51-247 1.59e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 56.13  E-value: 1.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  51 GFIAFILAVVMAIILSVGLFRFNktyqiktGQLRRTWPIAAVLIIGLPLLAQWLFGAALhwdvpalrGFNFRGGMVLIPE 130
Cdd:cd06261    8 ALIATLLALVLGLLLGIILARKR-------GKLDRLLRRIIDLLLSLPSLVLGLLLVLL--------FGVLLGWGILPGL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 131 LAALTLALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIG 210
Cdd:cd06261   73 GLPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLG 152

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 446330897 211 YPDMVSLFAGTVLNQTGQAIETIAMTMSVYLIISLTI 247
Cdd:cd06261  153 GGEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 133-258 3.59e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 49.22  E-value: 3.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  133 ALTLALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIG-Y 211
Cdd:pfam00528  54 PAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGsW 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 446330897  212 PDMVSLFAGTVLN-QTGQAIETIAMTMSVYLIISLTISLLMNIYNRRI 258
Cdd:pfam00528 134 PGLGLLLIEAILGyDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRV 181
 
Name Accession Description Interval E-value
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-263 2.79e-154

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 434.96  E-value: 2.79e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897   1 FRNIPPLLQIFFWYFAVLRNLPGPRQAVSAFDLAFLSNRGLYIPSPQLGDGFIAFILAVVMAIILSVGLFRFNKTYQIKT 80
Cdd:COG4597  135 FRNIPLLLQIFFWYFAVLEALPSPRQSLSLFDGVFLNNRGLYLPAPVFEPGFGWVLAALLAAIVAAFVLRRWARRRQEAT 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  81 GQLRRTWPIAAVLIIGLPLLAQWLFGAALHWDVPALRGFNFRGGMVLIPELAALTLALSVYTSAFIAEIIRAGIQAVPYG 160
Cdd:COG4597  215 GQRFPVWWISLALLVGLPLLAFLLLGAPLSLDYPELKGFNFRGGLTLSPEFVALLLALSLYTAAFIAEIVRAGIQAVSKG 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 161 QHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIGYPDMVSLFAGTVLNQTGQAIETIAMTMSVY 240
Cdd:COG4597  295 QTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSLAVAIGYPDLVSVFAGTTLNQTGQAIEIIAITMAVY 374

                        250       260
                 ....*....|....*....|...
gi 446330897 241 LIISLTISLLMNIYNRRIAIVER 263
Cdd:COG4597  375 LTISLLISLLMNWYNRRVALVER 397
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 52-260 2.65e-39

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 135.97  E-value: 2.65e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  52 FIAFILAVVMAIILSVGlfrfnKTYQIKTgqLRrtWPIAAV--LIIGLPLLAQ---WLFGaalhwdVPALrgfnfrgGMV 126
Cdd:COG0765   27 VLAIVLGLVLGLLLALA-----RLSPNPV--LR--WLATAYveFFRGTPLLVQlffIYFG------LPLL-------GID 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 127 LIPELAALtLALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLA 206
Cdd:COG0765   85 LSPFVAAV-IALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLV 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446330897 207 AAIGYPDMVSlFAGTVLNQTGQAIETIAMTMSVYLIISLTISLLMNIYNRRIAI 260
Cdd:COG0765  164 SVIGVPELTR-AAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLAR 216
PRK15100 PRK15100
cystine ABC transporter permease;
82-263 5.18e-18

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 80.18  E-value: 5.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  82 QLRRTWP---IAAVLII---GLPLLAQwLFgaALHWDVPALrgfnfrgGMVLIPELAALtLALSVYTSAFIAEIIRAGIQ 155
Cdd:PRK15100  44 RLSPIWPvrwLARFYVSifrGTPLIAQ-LF--MIYYGLPQF-------GIELDPIPAAM-IGLSLNTAAYAAETLRAAIS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 156 AVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIGYPDmvsLFAGTVLnQTGQAIETIAM 235
Cdd:PRK15100 113 SIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPE---LFRQAQL-ITSRTLEVFTM 188

                        170       180
                 ....*....|....*....|....*...
gi 446330897 236 TMSVYLIISLTISLLMNIYNRRIAIVER 263
Cdd:PRK15100 189 YLAASLIYWIMATVLSALQNRFENQLNR 216
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 86-258 1.00e-14

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 71.04  E-value: 1.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897   86 TWPIAAVL--IIGLPLLAQWLFgaaLHWDVPALrgfnfrgGMVLiPELAALTLALSVYTSAFIAEIIRAGIQAVPYGQHE 163
Cdd:TIGR03003  50 SWPTSFVVefIRGTPLLVQLYF---LYYVLPDI-------GIRL-PALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWE 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  164 AARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIGYPDMVSLfAGTVLNQTGQAIETIAMTMSVYLII 243
Cdd:TIGR03003 119 AATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELMNQ-AKSIGNSTFRYLEPMTLVGVFFLIL 197

                         170
                  ....*....|....*
gi 446330897  244 SLTISLLMNIYNRRI 258
Cdd:TIGR03003 198 SIISVFFLRRLEARL 212
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
131-257 2.03e-14

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 70.24  E-value: 2.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 131 LAALTLALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIG 210
Cdd:PRK15107  97 LISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLS 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446330897 211 YPDMVSLfAGTVLNQTGQAIETIAMTMSVYLIISLTISLLMNIYNRR 257
Cdd:PRK15107 177 LADFFRT-ASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKR 222
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 126-261 1.75e-13

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 67.77  E-value: 1.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 126 VLIPELAALTLALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSL 205
Cdd:PRK09494  85 LRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSL 164

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 206 AAAIGYPDMV----SLFAGTVlnqtgQAIETIAMTMSVYLIISLTISLLMNIYNRRIAIV 261
Cdd:PRK09494 165 FIVIGVAELTrqgqEIIAGNF-----RALEIWSAVAVIYLIITLVLSFILRRLERRMKIL 219
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
136-263 6.42e-12

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 63.54  E-value: 6.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 136 LALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIGYPDMV 215
Cdd:PRK11123 109 IALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVLLKDTALVSLISVNDLM 188

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446330897 216 sLFAGTVLNQTGQAIETIAMTMSVYLIISLTISLLMNIYNRRIAIVER 263
Cdd:PRK11123 189 -LQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELRATRFER 235
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 51-247 1.59e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 56.13  E-value: 1.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  51 GFIAFILAVVMAIILSVGLFRFNktyqiktGQLRRTWPIAAVLIIGLPLLAQWLFGAALhwdvpalrGFNFRGGMVLIPE 130
Cdd:cd06261    8 ALIATLLALVLGLLLGIILARKR-------GKLDRLLRRIIDLLLSLPSLVLGLLLVLL--------FGVLLGWGILPGL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 131 LAALTLALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIG 210
Cdd:cd06261   73 GLPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLG 152

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 446330897 211 YPDMVSLFAGTVLNQTGQAIETIAMTMSVYLIISLTI 247
Cdd:cd06261  153 GGEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
PRK15069 PRK15069
histidine ABC transporter permease HisM;
136-257 3.36e-07

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 49.66  E-value: 3.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 136 LALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIGYPDMV 215
Cdd:PRK15069 107 LAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTATVPDIL 186

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446330897 216 SLfAGTVLNQTGQAIETIAMTMSVYLIISLTISLLMNIYNRR 257
Cdd:PRK15069 187 KI-ARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERR 227
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 133-258 3.59e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 49.22  E-value: 3.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  133 ALTLALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIG-Y 211
Cdd:pfam00528  54 PAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGsW 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 446330897  212 PDMVSLFAGTVLN-QTGQAIETIAMTMSVYLIISLTISLLMNIYNRRI 258
Cdd:pfam00528 134 PGLGLLLIEAILGyDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRV 181
artM PRK11122
arginine ABC transporter permease ArtM;
52-263 9.44e-07

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 48.42  E-value: 9.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  52 FIAFILAVVMAIILSvglfrfnktyqIKTGQLRRTWPIAAVLIIGLPLLAQWLFGAALHWDVPALRGFNFRGGMVLIPEL 131
Cdd:PRK11122  24 LVALVLALIFTIILT-----------LKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGPGQFPWLQEYPWLWHLLSQPWL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 132 AALtLALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRqVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIGY 211
Cdd:PRK11122  93 CAM-LALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRALSSYSNEVVLVFKSTSLAYTITL 170

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446330897 212 PDMVSLfaGTVLNQTGQAIETIAMTMSVYLIISLTISLLMNIYNRRIAIVER 263
Cdd:PRK11122 171 MDVMGY--SQLLYGRTYDVMVFGAAGIIYLVVNGLLTLLMRLIERKALAFER 220
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
128-215 6.67e-04

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 40.16  E-value: 6.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 128 IPELAALTLALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAA 207
Cdd:PRK15135  90 IDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVS 169


                 ....*...
gi 446330897 208 AIGYPDMV 215
Cdd:PRK15135 170 LLGLEDVV 177
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 51-233 4.04e-03

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 37.74  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897  51 GFIAFILAVVMAIILSvglfrfnktyqIKTGQLRRTWP-----IAAVLIIGLP-----LLAQWLFGAALHWdVPALRGFN 120
Cdd:COG0601  102 ALLALLLALLIGIPLG-----------ILAALRRGSWLdrlitVLALLGISIPsfwlgLLLILLFAVKLGW-LPVSGRVS 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 121 FRGGMVLIPELAAL-TLALSVYTSAFIAEIIRAGIQAVPYGQH-EAARSLGLPNpvtlRQVIIPQALRVIIPPLTSQyln 198
Cdd:COG0601  170 PWEDFLDALRHLILpALTLALGSLAGIARLTRSSMLEVLGQDYvRTARAKGLSE----RRVLLRHALRNALIPVVTV--- 242

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 446330897 199 ivknssLAAAIGYpdmvsLFAGTVLnqtgqaIETI 233
Cdd:COG0601  243 ------LGLQLGG-----LLGGAVV------VETV 260
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 132-210 4.86e-03

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 441614  Cd Length: 220  Bit Score: 37.34  E-value: 4.86e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446330897 132 AALTLALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIG 210
Cdd:COG2011   93 TAAIVPLTIAAIPFFARLVENALREVDPGVIEAAQAMGASPWQIIFKVLLPEALPSLILGLTVTLISLIGYSAMAGAVG 171
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
102-190 6.20e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 37.83  E-value: 6.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446330897 102 QWLFGAALHWDVPALRGFnfrGGMVLipelaaltlALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVII 181
Cdd:COG1178  122 NTLLRALFGLEPPDIYGL---GGIIL---------VLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTL 189


                 ....*....
gi 446330897 182 PQALRVIIP 190
Cdd:COG1178  190 PLLRPAIAA 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH