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Conserved domains on  [gi|446337505|ref|WP_000415360|]
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MULTISPECIES: 3-isopropylmalate dehydrogenase [Bacillus]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10011514)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

CATH:  3.40.718.10
EC:  1.1.1.85
Gene Symbol:  leuB
Gene Ontology:  GO:0003862|GO:0046872|GO:0051287
SCOP:  4000791

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-346 0e+00

3-isopropylmalate dehydrogenase; Provisional


:

Pssm-ID: 234832  Cd Length: 358  Bit Score: 578.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   1 MEKRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWD 80
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  81 GV--KERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK--ADEIDFVVVRELTGGIYFSYPKERTD----EVATDT 152
Cdd:PRK00772  81 NLppDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPeiVAGLDILIVRELTGGIYFGEPRGREGlggeERAFDT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 153 LTYHRHEIERIVSYAFQLASKRKKKVTSIDKANVLESSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIV 232
Cdd:PRK00772 161 MVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVIV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 233 TENLFGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEE 312
Cdd:PRK00772 241 TENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIEA 320

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 446337505 313 AISAVLKSGKCTADI---GGTETTTSFTKAVMQEMEE 346
Cdd:PRK00772 321 AVEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAE 357
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-346 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 578.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   1 MEKRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWD 80
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  81 GV--KERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK--ADEIDFVVVRELTGGIYFSYPKERTD----EVATDT 152
Cdd:PRK00772  81 NLppDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPeiVAGLDILIVRELTGGIYFGEPRGREGlggeERAFDT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 153 LTYHRHEIERIVSYAFQLASKRKKKVTSIDKANVLESSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIV 232
Cdd:PRK00772 161 MVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVIV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 233 TENLFGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEE 312
Cdd:PRK00772 241 TENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIEA 320

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 446337505 313 AISAVLKSGKCTADI---GGTETTTSFTKAVMQEMEE 346
Cdd:PRK00772 321 AVEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAE 357
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 3-344 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 519.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   3 KRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDGv 82
Cdd:COG0473    2 YKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  83 KERPEKGLLALRKGLGVFANVRPVTVESATAHlsPLKK--ADEIDFVVVRELTGGIYFSYPKERT----DEVATDTLTYH 156
Cdd:COG0473   81 GVRPESGLLALRKELDLYANLRPAKLYPGLPS--PLKPeiVEGIDLVIVRENTEGLYFGIGGRIGtgtgEEVAIDTRVYT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 157 RHEIERIVSYAFQLASKRKKKVTSIDKANVLE-SSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTEN 235
Cdd:COG0473  159 RKGIERIARYAFELARKRRKKVTSVDKANVLKlTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 236 LFGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSfGLTREGCAIEEAIS 315
Cdd:COG0473  239 LFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-GEEEAADAIEAAVE 317

                        330       340
                 ....*....|....*....|....*....
gi 446337505 316 AVLKSGKCTADIGGTETTTSFTKAVMQEM 344
Cdd:COG0473  318 KVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 4-344 1.02e-169

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 476.12  E-value: 1.02e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505    4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDGV- 82
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   83 -KERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK--ADEIDFVVVRELTGGIYFSYPKERT-DEVATDTLTYHRH 158
Cdd:TIGR00169  81 rDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEeiAKGVDFVVVRELTGGIYFGEPKGREgEGEAWDTEVYTVP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  159 EIERIVSYAFQLASKRKKKVTSIDKANVLESSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFG 238
Cdd:TIGR00169 161 EIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTSNLFG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  239 DILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEEAISAVL 318
Cdd:TIGR00169 241 DILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAVKKVL 320

                         330       340
                  ....*....|....*....|....*.
gi 446337505  319 KSGKCTADIGGTETTTSFTKAVMQEM 344
Cdd:TIGR00169 321 AEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
4-340 2.68e-165

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 465.23  E-value: 2.68e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505    4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDGVK 83
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   84 ERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK-ADEIDFVVVRELTGGIYFSYPKERTD---EVATDTLTYHRHE 159
Cdd:pfam00180  81 VRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNeVEGVDIVIVRELTGGIYFGIEKGIKGsgnEVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  160 IERIVSYAFQLASKR-KKKVTSIDKANVLESSKLWR-TVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLF 237
Cdd:pfam00180 161 IERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRkIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  238 GDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEEAISAV 317
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEAAVLKV 320

                         330       340
                  ....*....|....*....|....*.
gi 446337505  318 LKSGKCTADIGGTET---TTSFTKAV 340
Cdd:pfam00180 321 LESGIRTGDLAGSATyvsTSEFGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
3-347 2.12e-88

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 268.91  E-value: 2.12e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   3 KRIVCLAGDGVGPEVMESAKEVLHMVERlyghHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRwdGV 82
Cdd:NF040626   2 YKITVIPGDGIGKEVMEAALYVLDALDL----NFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTP--GQ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  83 KErpekGLLALRKGLGVFANVRPVTVESATAHLSplkkaDEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIER 162
Cdd:NF040626  76 KS----PIITLRKELDLYANLRPIKSYEGINCLF-----KDLDFLIVRENTEGLYSGLEEEYTEEKAIAERVITRKASER 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 163 IVSYAFQLASKR-KKKVTSIDKANVLESSK-LWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFGDI 240
Cdd:NF040626 147 ICKFAFEYAIKLgRKKVTAVHKANVLKKTDgIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDI 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 241 LSDEASVLAGSLGMLPSASHAEKGpSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLgQSFGLTREGCAIEEAISAVLKS 320
Cdd:NF040626 227 LSDEAAGLVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMML-DYLGETYEANKLENALEKVLRE 304

                        330       340
                 ....*....|....*....|....*...
gi 446337505 321 GKC-TADIGGTETTTSFTKAVMQEMEEQ 347
Cdd:NF040626 305 GKVvTPDLGGNAKTMEMANEIKKKIEEL 332
AksF_Meth NF040619
homoisocitrate dehydrogenase;
4-340 3.92e-78

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 242.74  E-value: 3.92e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   4 RIVCLAGDGVGPEVMESAKEVLHMVerlygHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDGVK 83
Cdd:NF040619   3 KICVIEGDGIGKEVIPETVRVLKEL-----GDFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTELK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  84 ERPEKG-LLALRKGLGVFANVRPVTvesataHLSPLKKADEIDFVVVRELTGGIYFSypKERTD---EVATDTLTYHRHE 159
Cdd:NF040619  78 NKNYKSpILTLRKELDLYANVRPIN------NFGDGQDVKNIDFVIIRENTEGLYVG--REYYDeenEIAIAERIISKKG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 160 IERIVSYAFQLASK-RKKKVTSIDKANVLE-SSKLWRTVTEEVALRY--PDVELEHILVDAAAMELIRNPGRFDVIVTEN 235
Cdd:NF040619 150 SERIIKFAFEYAKKnNRKKVSCIHKANVLRvTDGLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPEMFDVIVTTN 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 236 LFGDILSDEASVLAGSLGMLPSASHAEKgPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLgQSFGLTREGCAIEEAIS 315
Cdd:NF040619 230 LFGDILSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMML-DYLGMKEKGDLIREAVK 307

                        330       340
                 ....*....|....*....|....*
gi 446337505 316 AVLKSGKCTADIGGTETTTSFTKAV 340
Cdd:NF040619 308 KCLENGKVTPDLGGNLKTKEVTDKI 332
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-346 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 578.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   1 MEKRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWD 80
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  81 GV--KERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK--ADEIDFVVVRELTGGIYFSYPKERTD----EVATDT 152
Cdd:PRK00772  81 NLppDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPeiVAGLDILIVRELTGGIYFGEPRGREGlggeERAFDT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 153 LTYHRHEIERIVSYAFQLASKRKKKVTSIDKANVLESSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIV 232
Cdd:PRK00772 161 MVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVIV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 233 TENLFGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEE 312
Cdd:PRK00772 241 TENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIEA 320

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 446337505 313 AISAVLKSGKCTADI---GGTETTTSFTKAVMQEMEE 346
Cdd:PRK00772 321 AVEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAE 357
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 3-344 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 519.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   3 KRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDGv 82
Cdd:COG0473    2 YKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  83 KERPEKGLLALRKGLGVFANVRPVTVESATAHlsPLKK--ADEIDFVVVRELTGGIYFSYPKERT----DEVATDTLTYH 156
Cdd:COG0473   81 GVRPESGLLALRKELDLYANLRPAKLYPGLPS--PLKPeiVEGIDLVIVRENTEGLYFGIGGRIGtgtgEEVAIDTRVYT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 157 RHEIERIVSYAFQLASKRKKKVTSIDKANVLE-SSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTEN 235
Cdd:COG0473  159 RKGIERIARYAFELARKRRKKVTSVDKANVLKlTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 236 LFGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSfGLTREGCAIEEAIS 315
Cdd:COG0473  239 LFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-GEEEAADAIEAAVE 317

                        330       340
                 ....*....|....*....|....*....
gi 446337505 316 AVLKSGKCTADIGGTETTTSFTKAVMQEM 344
Cdd:COG0473  318 KVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 4-344 1.02e-169

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 476.12  E-value: 1.02e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505    4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDGV- 82
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   83 -KERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK--ADEIDFVVVRELTGGIYFSYPKERT-DEVATDTLTYHRH 158
Cdd:TIGR00169  81 rDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEeiAKGVDFVVVRELTGGIYFGEPKGREgEGEAWDTEVYTVP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  159 EIERIVSYAFQLASKRKKKVTSIDKANVLESSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFG 238
Cdd:TIGR00169 161 EIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTSNLFG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  239 DILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEEAISAVL 318
Cdd:TIGR00169 241 DILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAVKKVL 320

                         330       340
                  ....*....|....*....|....*.
gi 446337505  319 KSGKCTADIGGTETTTSFTKAVMQEM 344
Cdd:TIGR00169 321 AEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
4-340 2.68e-165

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 465.23  E-value: 2.68e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505    4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDGVK 83
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   84 ERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK-ADEIDFVVVRELTGGIYFSYPKERTD---EVATDTLTYHRHE 159
Cdd:pfam00180  81 VRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNeVEGVDIVIVRELTGGIYFGIEKGIKGsgnEVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  160 IERIVSYAFQLASKR-KKKVTSIDKANVLESSKLWR-TVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLF 237
Cdd:pfam00180 161 IERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRkIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  238 GDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEEAISAV 317
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEAAVLKV 320

                         330       340
                  ....*....|....*....|....*.
gi 446337505  318 LKSGKCTADIGGTET---TTSFTKAV 340
Cdd:pfam00180 321 LESGIRTGDLAGSATyvsTSEFGEAV 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 5-327 1.46e-108

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 323.18  E-value: 1.46e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   5 IVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDGVKE 84
Cdd:PLN02329  49 IALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNEK 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  85 --RPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK--ADEIDFVVVRELTGGIYFSYPK-----ERTDEVATDTLTY 155
Cdd:PLN02329 129 hlRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKevAEGVDMMIVRELTGGIYFGEPRgitinENGEEVGVSTEIY 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 156 HRHEIERIVSYAFQLASKRKKKVTSIDKANVLESSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTEN 235
Cdd:PLN02329 209 AAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNN 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 236 LFGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEEAIS 315
Cdd:PLN02329 289 IFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVV 368

                        330
                 ....*....|..
gi 446337505 316 AVLKSGKCTADI 327
Cdd:PLN02329 369 DALNKGFRTGDI 380
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 5-340 5.87e-92

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 277.80  E-value: 5.87e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505    5 IVCLAGDGVGPEVMESAKEVLHMverlYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDGVKE 84
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNK----LGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPANPGYKS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   85 RpekgLLALRKGLGVFANVRPVTVESATAHLSPLkkadEIDFVVVRELTGGIYFSYpKERTDEVATDTLTYHRHEIERIV 164
Cdd:TIGR02088  77 V----IVTLRKELDLYANVRPAKSLPGIPDLYPN----GKDIVIVRENTEGLYAGF-EFGFSDRAIAIRVITREGSERIA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  165 SYAFQLASKRKKKVTSIDKANVLESS-KLWRTVTEEVALRYpDVELEHILVDAAAMELIRNPGRFDVIVTENLFGDILSD 243
Cdd:TIGR02088 148 RFAFNLAKERNRKVTCVHKANVLKGTdGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTNMFGDILSD 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  244 EASVLAGSLGMLPSASHAEKgPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLgQSFGLTREGCAIEEAISAVLKSGKC 323
Cdd:TIGR02088 227 LASALAGSLGLAPSANIGDR-KALFEPVHGSAPDIAGKGIANPTAAILSVAMML-DYLGELEKGKLVWEAVEYYIIEGKK 304

                         330
                  ....*....|....*..
gi 446337505  324 TADIGGTETTTSFTKAV 340
Cdd:TIGR02088 305 TPDLGGTAKTKEVGDEI 321
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
3-347 2.12e-88

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 268.91  E-value: 2.12e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   3 KRIVCLAGDGVGPEVMESAKEVLHMVERlyghHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRwdGV 82
Cdd:NF040626   2 YKITVIPGDGIGKEVMEAALYVLDALDL----NFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTP--GQ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  83 KErpekGLLALRKGLGVFANVRPVTVESATAHLSplkkaDEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIER 162
Cdd:NF040626  76 KS----PIITLRKELDLYANLRPIKSYEGINCLF-----KDLDFLIVRENTEGLYSGLEEEYTEEKAIAERVITRKASER 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 163 IVSYAFQLASKR-KKKVTSIDKANVLESSK-LWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFGDI 240
Cdd:NF040626 147 ICKFAFEYAIKLgRKKVTAVHKANVLKKTDgIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDI 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 241 LSDEASVLAGSLGMLPSASHAEKGpSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLgQSFGLTREGCAIEEAISAVLKS 320
Cdd:NF040626 227 LSDEAAGLVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMML-DYLGETYEANKLENALEKVLRE 304

                        330       340
                 ....*....|....*....|....*...
gi 446337505 321 GKC-TADIGGTETTTSFTKAVMQEMEEQ 347
Cdd:NF040626 305 GKVvTPDLGGNAKTMEMANEIKKKIEEL 332
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 3-344 3.49e-85

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 260.84  E-value: 3.49e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   3 KRIVCLAGDGVGPEVMESAKEVLHMVerlyGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGgprwdgv 82
Cdd:PRK14025   2 HKICVIEGDGIGKEVVPAALHVLEAT----GLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  83 kERPEKGLLALRKGLGVFANVRPVTVESATAHLSPlkkadEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIER 162
Cdd:PRK14025  71 -ETAADVIVKLRRILDTYANVRPVKSYKGVKCLYP-----DIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASER 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 163 IVSYAFQLASKRKK-----KVTSIDKANVLE-SSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENL 236
Cdd:PRK14025 145 IFRFAFEMAKRRKKmgkegKVTCAHKANVLKkTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 237 FGDILSDEASVLAGSLGMLPSASHAEKGpSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLgQSFGLTREGCAIEEAISA 316
Cdd:PRK14025 225 FGDILSDGAAGLVGGLGLAPSANIGDKY-GLFEPVHGSAPDIAGKGIANPTATILTAVLML-RHLGENEEADKVEKALEE 302

                        330       340
                 ....*....|....*....|....*...
gi 446337505 317 VLKSGKCTADIGGTETTTSFTKAVMQEM 344
Cdd:PRK14025 303 VLALGLTTPDLGGNLSTMEMAEEVAKRV 330
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 4-328 1.09e-84

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 259.86  E-value: 1.09e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   4 RIVCLAGDGVGPEVMESAKEVLHMVERLyghHFHLQDEHF--GGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRW-D 80
Cdd:PRK03437   6 KLAVIPGDGIGPEVVAEALKVLDAVAAG---GPGVETTEYdlGARRYLRTGETLPDSVLAELRQHDAILLGAIGDPSVpS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  81 GVKERpekG-LLALRKGLGVFANVRPVTVESATAhlSPLKKADEIDFVVVRELTGGIYF----SYPKERTDEVATDTLTY 155
Cdd:PRK03437  83 GVLER---GlLLKLRFALDHYVNLRPSKLYPGVT--SPLAGPGDIDFVVVREGTEGPYTgnggALRVGTPHEVATEVSVN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 156 HRHEIERIVSYAFQLASKRK-KKVTSIDKANVLE-SSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVT 233
Cdd:PRK03437 158 TAFGVERVVRDAFERAQKRPrKHLTLVHKTNVLTfAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 234 ENLFGDILSDEASVLAGSLGMLPSAS-HAEK-GPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQsFGLTREGCAIE 311
Cdd:PRK03437 238 DNLFGDIITDLAAAVTGGIGLAASGNiNPTGtNPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDH-LGEEDAAARIE 316

                        330       340
                 ....*....|....*....|.
gi 446337505 312 EAISAVL----KSGKCTADIG 328
Cdd:PRK03437 317 AAVEADLaergKMGRSTAEVG 337
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 1-344 7.30e-83

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 255.03  E-value: 7.30e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   1 MEKRIVCLAGDGVGPEVMESAKEVLHMVerlyGHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWD 80
Cdd:PRK08997   1 MKQTITVIPGDGIGPSIIDATLKILDKL----GCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  81 GVKERPekglLALRKGLGVFANVRPVTVESATAhlsplKKADEIDFVVVRELTGGIYFSYPKERTD--EVATDTLTYHRH 158
Cdd:PRK08997  77 GFTSIN----VTLRKKFDLYANVRPVLSFPGTK-----ARYDNIDIITVRENTEGMYSGEGQTVSEdgETAEATSIITRK 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 159 EIERIVSYAFQLASKR-KKKVTSIDKANVLES-SKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENL 236
Cdd:PRK08997 148 GAERIVRFAYELARKEgRKKVTAVHKANIMKStSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 237 FGDILSDEASVLAGSLGMLPSASHAEKGpSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLgQSFGLTREGCAIEEAISA 316
Cdd:PRK08997 228 FGDILSDLCAGLVGGLGMAPGANIGRDA-AIFEAVHGSAPDIAGKNLANPTSVILAAIQML-EYLGMPDKAERIRKAIVA 305

                        330       340
                 ....*....|....*....|....*....
gi 446337505 317 VLKSG-KCTADIGGTETTTSFTKAVMQEM 344
Cdd:PRK08997 306 VIEAGdRTTRDLGGTHGTTDFTQAVIDRL 334
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 2-340 2.63e-81

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 251.68  E-value: 2.63e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505    2 EKRIVCLAGDGVGPEVMESAKEVLHMVERLYGHhFHLQDEHF--GGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPrw 79
Cdd:TIGR02089   3 QYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGG-FSLHFTEFpwSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWP-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   80 dgvKERPEK-----GLLALRKGLGVFANVRPVTVESATAhlSPLK--KADEIDFVVVRELTGGIYFSYP----KERTDEV 148
Cdd:TIGR02089  80 ---ALVPDHislwgLLLKIRREFDQYANVRPAKLLPGVT--SPLRncGPGDFDFVVVRENSEGEYSGVGgrihRGTDEEV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  149 ATDTLTYHRHEIERIVSYAFQLASKRKKKVTSIDKAN-VLESSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGR 227
Cdd:TIGR02089 155 ATQNAIFTRKGVERIMRFAFELAQKRRKHLTSATKSNgIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPET 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  228 FDVIVTENLFGDILSDEASVLAGSLGMLPSASHAEKG--PSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLgQSFGLTR 305
Cdd:TIGR02089 235 FDVIVASNLFGDILSDLGAALMGSLGVAPSANINPEGkfPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMML-EHLGEKE 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 446337505  306 EGCAIEEAISAVLKSGKCTADIGGTETTTSFTKAV 340
Cdd:TIGR02089 314 AGAKIMDAIERVTAAGILTPDVGGKATTSEVTEAV 348
AksF_Meth NF040619
homoisocitrate dehydrogenase;
4-340 3.92e-78

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 242.74  E-value: 3.92e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   4 RIVCLAGDGVGPEVMESAKEVLHMVerlygHHFHLQDEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDGVK 83
Cdd:NF040619   3 KICVIEGDGIGKEVIPETVRVLKEL-----GDFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTELK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  84 ERPEKG-LLALRKGLGVFANVRPVTvesataHLSPLKKADEIDFVVVRELTGGIYFSypKERTD---EVATDTLTYHRHE 159
Cdd:NF040619  78 NKNYKSpILTLRKELDLYANVRPIN------NFGDGQDVKNIDFVIIRENTEGLYVG--REYYDeenEIAIAERIISKKG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 160 IERIVSYAFQLASK-RKKKVTSIDKANVLE-SSKLWRTVTEEVALRY--PDVELEHILVDAAAMELIRNPGRFDVIVTEN 235
Cdd:NF040619 150 SERIIKFAFEYAKKnNRKKVSCIHKANVLRvTDGLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPEMFDVIVTTN 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 236 LFGDILSDEASVLAGSLGMLPSASHAEKgPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLgQSFGLTREGCAIEEAIS 315
Cdd:NF040619 230 LFGDILSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMML-DYLGMKEKGDLIREAVK 307

                        330       340
                 ....*....|....*....|....*
gi 446337505 316 AVLKSGKCTADIGGTETTTSFTKAV 340
Cdd:NF040619 308 KCLENGKVTPDLGGNLKTKEVTDKI 332
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 4-340 1.10e-74

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 234.62  E-value: 1.10e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGH-HFHLQD---------EHfggvaidltGQPLPQRTLAACLASDAVLLGA 73
Cdd:PRK08194   5 KIAVIPGDGVGKEVVPAAVRVLKAVAEVHGGlKFEFTEfpwsceyylEH---------GEMMPEDGLEQLKQFDAIFLGA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  74 VGGPR--------WdGVkerpekgLLALRKGLGVFANVRPVTVESATAhlSPLKKADEIDFVVVRELTGGIYFS-----Y 140
Cdd:PRK08194  76 VGNPKlvpdhislW-GL-------LIKIRREFEQVINIRPAKQLRGIK--SPLANPKDFDLLVVRENSEGEYSEvggriH 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 141 PKErtDEVATDTLTYHRHEIERIVSYAFQLASKRKKKVTSIDKAN-VLESSKLWRTVTEEVALRYPDVELEHILVDAAAM 219
Cdd:PRK08194 146 RGE--DEIAIQNAVFTRKGTERAMRYAFELAAKRRKHVTSATKSNgIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAA 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 220 ELIRNPGRFDVIVTENLFGDILSDEASVLAGSLGMLPSASHAEKG--PSLYEPIHGSAPDIAGKNKANPIAMMRSVAMML 297
Cdd:PRK08194 224 FFVTRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGkyPSMFEPVHGSAPDIAGKGIANPIGQIWTAKLML 303

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 446337505 298 gQSFGLTREGCAIEEAISAVLKSGKCTADIGGTETTTSFTKAV 340
Cdd:PRK08194 304 -DHFGEEELGSHLLDVIEDVTEDGIKTPDIGGRATTDEVTDEI 345
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 10-344 1.30e-61

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 201.65  E-value: 1.30e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  10 GDGVGPEVMESAKEVLHMVERLYGhhfhlQDEHFGGVAID-LTGQPLPQRTLAACLASDAVLLGAVGGPRWDGVKERPek 88
Cdd:PLN00118  49 GDGIGPEIAESVKQVFTAAGVPIE-----WEEHYVGTTVDpRTGSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLN-- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  89 glLALRKGLGVFANVRPVTvesataHLSPLK-KADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSYA 167
Cdd:PLN00118 122 --LTLRKELGLYANVRPCY------SLPGYKtRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQASLRVAEYA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 168 FQLASKR-KKKVTSIDKANVLESSK-LWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEA 245
Cdd:PLN00118 194 FHYAKTHgRKRVSAIHKANIMKKTDgLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLC 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 246 SVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLgQSFGLTREGCAIEEAISAVLKSGKC-T 324
Cdd:PLN00118 274 AGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMML-RHLKLNEQAEQIHNAILNTIAEGKYrT 352

                        330       340
                 ....*....|....*....|
gi 446337505 325 ADIGGTETTTSFTKAVMQEM 344
Cdd:PLN00118 353 ADLGGSSTTTDFTKAICDHL 372
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 10-344 4.04e-61

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 199.14  E-value: 4.04e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   10 GDGVGPEVMESAKEVL-HMVERLYGHHFHLQDE-HFGGVAIDLTGQPLPQRTLAaclasdavLLGAVGGPrwdgVKERPE 87
Cdd:TIGR00175  11 GDGIGPEISGSVKKIFrAANVPIEFEEIDVSPQtDGKTEIPDEAVESIKRNKVA--------LKGPLETP----IGKGGH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   88 KGL-LALRKGLGVFANVRP-VTVES-ATAHlsplkkaDEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIV 164
Cdd:TIGR00175  79 RSLnVALRKELDLYANVVHcKSLPGfKTRH-------EDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  165 SYAFQLASKR-KKKVTSIDKANVLE-SSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFGDILS 242
Cdd:TIGR00175 152 RYAFEYARKNgRKKVTAVHKANIMKlADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILS 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  243 DEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLgQSFGLTREGCAIEEAISAVLKSGK 322
Cdd:TIGR00175 232 NLGAGLVGGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMML-NHLGLKEHADRIQKAVLSTIAEGK 310

                         330       340
                  ....*....|....*....|...
gi 446337505  323 C-TADIGGTETTTSFTKAVMQEM 344
Cdd:TIGR00175 311 NrTKDLGGTATTSDFTEAVIKRL 333
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-342 6.37e-58

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 194.72  E-value: 6.37e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   1 MEKRIVCLA-GDGVGPEVMESakeVLHMVERlyghhfhlqdehfGGVAIDLT----GQPLPQRTLAACLASDA------- 68
Cdd:PRK09222   2 AEKTPITVAyGDGIGPEIMEA---VLKILEA-------------AGAPLEIEtieiGEKVYKKGWTSGISPSAwesirrt 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  69 -VLLGA-----VGGprwdGvkerpEKGL-LALRKGLGVFANVRPVTvesataHLSPL--KKADEIDFVVVRE----LTGG 135
Cdd:PRK09222  66 kVLLKApittpQGG----G-----YKSLnVTLRKTLGLYANVRPCV------SYHPFveTKHPNLDVVIIREneedLYAG 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 136 IYFsypkERTDEVATDTLTYHRHEIERIVSYAFQLASKR-KKKVTSIDKANVLE-SSKLWRTVTEEVALRYPDVELEHIL 213
Cdd:PRK09222 131 IEH----RQTPDVYQCLKLISRPGSEKIIRYAFEYARANgRKKVTCLTKDNIMKlTDGLFHKVFDEIAKEYPDIEAEHYI 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 214 VDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLGMLPSASHAEKGpSLYEPIHGSAPDIAGKNKANPIAMMRSV 293
Cdd:PRK09222 207 VDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEY-AMFEAVHGSAPDIAGKNIANPSGLLNAA 285

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446337505 294 AMMLgQSFGLTREGCAIEEAISAVLKSGKCTADIGGTET------TTSFTKAVMQ 342
Cdd:PRK09222 286 VMML-VHIGQFDIAELIENAWLKTLEDGIHTADIYNEGVskkkvgTKEFAEAVIE 339
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 5-346 1.19e-43

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 155.27  E-value: 1.19e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   5 IVCLAGDGVGPEVMESAKEVLH-MVERLYGHHFHLQDEHF--GGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDG 81
Cdd:COG0538   21 IPFIEGDGIGPEITRAIWKVIDaAVEKAYGGKRDIEWKEVdaGEKARDETGDWLPDETAEAIKEYGVGIKGPLTTPVGGG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  82 VKErpekglL--ALRKGLGVFANVRPVTVESATAhlSPLKKADEIDFVVVRELTGGIY----FSYPKERTDEVaTDTL-- 153
Cdd:COG0538  101 WRS------LnvTIRQILDLYVCRRPVRYFKGVP--SPVKHPEKVDIVIFRENTEDIYagieWKAGSPEALKL-IFFLed 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 154 ----TYHRHE--------------IERIVSYAFQLA-SKRKKKVTSIDKANVLESS----KLW-----------RTVTEE 199
Cdd:COG0538  172 emgvTVIRFPedsgigikpvsdegTERLVRAAIQYAlDNKRKSVTLVHKGNIMKFTegafKDWgyevaeeefgdKFITEG 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 200 VALRYP------DVELEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHG 273
Cdd:COG0538  252 PWEKYKgpkpagKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGGAEFEATHG 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 274 SAPDIAGKNKANPIAMMRSVAMML---GQsfgltREGC-AIEEAISAVLKSGKCTADI-----GGTETTTS-FTKAVMQE 343
Cdd:COG0538  332 TAPKYAGKDSTNPGSLILSGTMMLrhrGW-----LEAAdLIEKAVEKTIESGKVTYDLarlmeGATELSTSeFGDAIIEN 406


                 ...
gi 446337505 344 MEE 346
Cdd:COG0538  407 LDK 409
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
5-345 6.07e-42

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 151.14  E-value: 6.07e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   5 IVCLAGDGVGPEVMESAKEVLH-MVERLYGHHFHLQ--DEHFGGVAIDLTGQPLPQRTLAACLASDAVLLGAVGGPRWDG 81
Cdd:PRK06451  26 ILYVEGDGIGPEITHAAMKVINkAVEKAYGSDREIKwvEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPIGKG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  82 VKERPekglLALRKGLGVFANVRPVTVESATAhlSPLKKADEIDFVVVRELTG----GIYFSYPKERTD----------- 146
Cdd:PRK06451 106 WKSIN----VAIRLMLDLYANIRPVKYIPGIE--SPLKNPEKIDLIIFRENTDdlyrGIEYPYDSEEAKkirdflrkelg 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 147 -EVATDT----LTYHRHEIERIVSYAFQLA-SKRKKKVTSIDKANVLESSK-LWRTVTEEVALR-YPD------------ 206
Cdd:PRK06451 180 vEVEDDTgigiKLISKFKTQRIARMAIKYAiDHKRKKVTIMHKGNVMKYTEgAFREWAYEVALKeFRDyvvteeevtkny 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 207 --------VELEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLGMLPSASHAEKGpSLYEPIHGSAPDI 278
Cdd:PRK06451 260 ngvppsgkVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTG-GMFEAIHGTAPKY 338

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446337505 279 AGKNKANPIAMMRSVAMMLgQSFGLTREGCAIEEAISAVLKSGKCTADIG---GTE--TTTSFTKAVMQEME 345
Cdd:PRK06451 339 AGKNVANPTGIIKGGELML-RFMGWDKAADLIDKAIMESIKQKKVTQDLArfmGVRalSTTEYTDELISIID 409
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 4-345 2.21e-36

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 134.99  E-value: 2.21e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505   4 RIVCL-AGDGVGPEVMESAKEVLH-MVERLYGHHFhlqdEHFGGVaidltgQPLPQRTLAACLASDAVLLGAVGGPRWDG 81
Cdd:PLN00123  31 RAVTLiPGDGIGPLVTGAVEQVMEaMHAPVYFERY----EVHGDM------KKVPEEVLESIRRNKVCLKGGLATPVGGG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  82 VKERPekglLALRKGLGVFANVrpVTVES----ATAHlsplkkaDEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHR 157
Cdd:PLN00123 101 VSSLN----VQLRKELDLFASL--VNCFNlpglPTRH-------ENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITK 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 158 HEIERIVSYAFQLAS-KRKKKVTSIDKANVLE-SSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTEN 235
Cdd:PLN00123 168 FCSERIAKYAFEYAYlNNRKKVTAVHKANIMKlADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPN 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 236 LFGDILSDEASVLAGSLGMLP----SASHA--EKGPSlyepiHGSA--PDIAGKNKANPIAMMRSVAMMLgQSFGLTREG 307
Cdd:PLN00123 248 LYGNLVANTAAGIAGGTGVMPggnvGADHAvfEQGAS-----AGNVgnEKLVEQKKANPVALLLSSAMML-RHLQFPSFA 321

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 446337505 308 CAIEEAISAVLKSGKC-TADIGGTETTTSFTKAVMQEME 345
Cdd:PLN00123 322 DRLETAVKRVIAEGKYrTKDLGGSSTTQEVVDAVIANLD 360
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 10-344 3.04e-21

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 93.97  E-value: 3.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  10 GDGVGPEVMESAKEVLHM-VERLYG--HHFHLQDEHFGGVAIDLTGQP--LPQRTLAA----CLASDAVLLGAVGGprwd 80
Cdd:PRK07006  27 GDGIGPDITPAMLKVVDAaVEKAYKgeRKISWMEIYAGEKATKVYGEDvwLPEETLDLireyRVAIKGPLTTPVGG---- 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  81 GVKERPekglLALRKGLGVFANVRPVTVESATAhlSPLKKADEIDFVVVRELTGGIYFSYP-KERTDEvATDTLTYHRHE 159
Cdd:PRK07006 103 GIRSLN----VALRQELDLYVCLRPVRYFKGVP--SPVKRPEDTDMVIFRENSEDIYAGIEwKAGSAE-AKKVIKFLQEE 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 160 I-----------------------ERIVSYAFQLASKRKKK-VTSIDKANVLE----SSKLW------RTVTEEV----- 200
Cdd:PRK07006 176 MgvkkirfpetsgigikpvseegtERLVRAAIEYAIDNDRKsVTLVHKGNIMKftegAFKDWgyqlaeEEFGDELidggp 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 201 --ALRYPDVELEHILVDAAA----MELIRNPGRFDVIVTENLFGDILSDEASVLAGSLGMLPSA----SHAekgpsLYEP 270
Cdd:PRK07006 256 wdKIKNPETGKEIIVKDSIAdaflQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGAnindGHA-----IFEA 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 271 IHGSAPDIAGKNKANPIAMMRSVAMMLgQSFGLTREGCAIEEAISAVLKSGKCTADI-----GGTETTTS-FTKAVMQEM 344
Cdd:PRK07006 331 THGTAPKYAGLDKVNPGSVILSAEMML-RHMGWTEAADLIIKSMEKTIASKTVTYDFarlmeGATEVKCSeFGDALIKNM 409
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
10-327 4.79e-15

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 75.91  E-value: 4.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  10 GDGVGPEVMESAKEVLH-MVERLYGHHFHLqdEHF----GGVAIDLTG--QPLPQRTLAACLASDAVLLGAVGGPRWDGV 82
Cdd:PRK07362  36 GDGTGVDIWPATQKVLDaAVAKAYGGERKI--NWFkvyaGDEACDLYGtyQYLPEDTLEAIREYGVAIKGPLTTPIGGGI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505  83 KERPekglLALRKGLGVFANVRPVTVESATAhlSPLKKADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEI-- 160
Cdd:PRK07362 114 RSLN----VALRQIFDLYSCVRPCRYYAGTP--SPHKNPEKLDVIVYRENTEDIYMGIEWEAGDEIGDKLIKHLNEEVip 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 161 --------------------------ERIVSYAFQLA---SKRKKKVTSIDKANVLE----SSKLW-----------RTV 196
Cdd:PRK07362 188 aspelgkrqiplgsgigikpvsktgsQRHIRRAIEHAlrlPGDKRHVTLVHKGNIMKytegAFRDWgyelattefrdECV 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 197 TEEVAL------RYPDVELEH-------------------------------------------ILVDAAAMELI----- 222
Cdd:PRK07362 268 TERESWilsnkeKNPNISIEDnarmiepgydsltpekkaaicaevkevldsiwsshgngkwkekVLVDDRIADSIfqqiq 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 223 RNPGRFDVIVTENLFGDILSDEASVLAGSLGMLPSASHAEKGpSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLgQSFG 302
Cdd:PRK07362 348 TRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNA-AIFEATHGTAPKHAGLDRINPGSVILSGVMML-EYLG 425

                        410       420
                 ....*....|....*....|....*
gi 446337505 303 LTREGCAIEEAISAVLKSGKCTADI 327
Cdd:PRK07362 426 WQEAADLITKGLSAAIANKQVTYDL 450
PLN00096 PLN00096
isocitrate dehydrogenase (NADP+); Provisional
 205-344 2.93e-05

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177715  Cd Length: 393  Bit Score: 45.41  E-value: 2.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 205 PDVELEHILVDAAAMELIR-NPGRFDvIVTENLFGDILSDEASVLAGSLGMLPS--ASHAEKGPSL--YEPIHGSAPDI- 278
Cdd:PLN00096 235 SGDELVHLLSDAATMKLVVwTDGGFG-MAAHNYDGDVLTDELAQVHKSPGFITSnlVGVDENGTLIkeFEASHGTVTDMd 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446337505 279 -----AGKNKANPIAM-------MRSVAMMLGQSFGLTREGCAIEEAISAVLKSGKCTADIGGTE--TTTSFTKAVMQEM 344
Cdd:PLN00096 314 earlrGEETSLNPLGMvegligaMNHAADVHGGKERVHPFTAKLRAVIHKLFREGRGTRDLCGAGglTTEQFIDAVAEEL 393
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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