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Conserved domains on  [gi|446338209|ref|WP_000416064|]
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MULTISPECIES: hemolysin expression modulator Hha [Enterobacteriaceae]

Protein Classification

HHA domain-containing protein( domain architecture ID 28225)

HHA domain-containing protein similar to hemolysin expression-modulating protein Hha may play a role in the regulation of gene expression in response to environmental factors

CATH:  1.20.1280.40
PubMed:  15458420
SCOP:  4002903

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HHA super family cl11501
Haemolysin expression modulating protein; This family consists of haemolysin expression ...
 4-69 1.47e-29

Haemolysin expression modulating protein; This family consists of haemolysin expression modulating protein (HHA) homologs. YmoA and Hha are highly similar bacterial proteins downregulating gene expression in Yersinia enterocolitica and Escherichia coli, respectively.


The actual alignment was detected with superfamily member PRK10945:

Pssm-ID: 448287  Cd Length: 72  Bit Score: 99.17  E-value: 1.47e-29
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446338209  4 TKQEWLYQLRRCSSLKTLEKIIAKNQGTLASDKIEAFNSAVDHRLAELTMNKLYDKVPASVWKHVK 69
Cdd:PRK10945  7 TKTDYLMRLRRCQTIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR 72
 
Name Accession Description Interval E-value
PRK10945 PRK10945
hemolysin expression modulator Hha;
4-69 1.47e-29

hemolysin expression modulator Hha;


Pssm-ID: 182856  Cd Length: 72  Bit Score: 99.17  E-value: 1.47e-29
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446338209  4 TKQEWLYQLRRCSSLKTLEKIIAKNQGTLASDKIEAFNSAVDHRLAELTMNKLYDKVPASVWKHVK 69
Cdd:PRK10945  7 TKTDYLMRLRRCQTIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR 72
HHA pfam05321
Haemolysin expression modulating protein; This family consists of haemolysin expression ...
 11-65 2.12e-22

Haemolysin expression modulating protein; This family consists of haemolysin expression modulating protein (HHA) homologs. YmoA and Hha are highly similar bacterial proteins downregulating gene expression in Yersinia enterocolitica and Escherichia coli, respectively.


Pssm-ID: 428422  Cd Length: 56  Bit Score: 80.74  E-value: 2.12e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446338209  11 QLRRCSSLKTLEKIIAKNQGTLASDKIEAFNSAVDHRLAELTMNKLYDKVPASVW 65
Cdd:pfam05321  2 RLRRCSSIDTLEKVIEKNKYELTNDELSSFYSAADHRLAELTMGKLYDKIPKSVW 56
 
Name Accession Description Interval E-value
PRK10945 PRK10945
hemolysin expression modulator Hha;
4-69 1.47e-29

hemolysin expression modulator Hha;


Pssm-ID: 182856  Cd Length: 72  Bit Score: 99.17  E-value: 1.47e-29
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446338209  4 TKQEWLYQLRRCSSLKTLEKIIAKNQGTLASDKIEAFNSAVDHRLAELTMNKLYDKVPASVWKHVK 69
Cdd:PRK10945  7 TKTDYLMRLRRCQTIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR 72
HHA pfam05321
Haemolysin expression modulating protein; This family consists of haemolysin expression ...
 11-65 2.12e-22

Haemolysin expression modulating protein; This family consists of haemolysin expression modulating protein (HHA) homologs. YmoA and Hha are highly similar bacterial proteins downregulating gene expression in Yersinia enterocolitica and Escherichia coli, respectively.


Pssm-ID: 428422  Cd Length: 56  Bit Score: 80.74  E-value: 2.12e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446338209  11 QLRRCSSLKTLEKIIAKNQGTLASDKIEAFNSAVDHRLAELTMNKLYDKVPASVW 65
Cdd:pfam05321  2 RLRRCSSIDTLEKVIEKNKYELTNDELSSFYSAADHRLAELTMGKLYDKIPKSVW 56
PRK10391 PRK10391
transcription modulator YdgT;
4-68 3.16e-08

transcription modulator YdgT;


Pssm-ID: 182426  Cd Length: 71  Bit Score: 45.19  E-value: 3.16e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338209  4 TKQEWLYQLRRCSSLKTLEKIIAKNQGTLaSDKIEAFN--SAVDHRLAELTMN-KLYD--KVPASVWKHV 68
Cdd:PRK10391  2 TVQDYLLKFRKISSLESLEKLFDHLNYTL-TDDQEIINmyRAADHRRAELVSGgRLFDlgQVPKSVWHYV 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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